Curriculum Vitae s9

CURRICULUM VITAE

NAME Andrew Michael Prantner, PhD.

CURRENT POSITION Postdoctoral fellow

LABORATORY Ovarian Cancer Research Center University of Pennsylvania Room 1336, Biomedical Research Building II/III 421 Curie Blvd. Philadelphia, PA, 19104-6160 Phone: (215) 898 0165 – Fax : (215) 573 5129 Email: [email protected]

EDUCATION 2008 Ph.D. in Biochemistry Washington University in St. Louis, St. Louis, MO. Dissertation: Re-evaluation of transmembrane water exchange in rat brain Advisors: Drs. Joseph J.H. Ackerman & Jeffrey J. Neil. 1999 M.S. in Chemistry University of Pennsylvania, Philadelphia, PA. Thesis: NMR Studies of Proteins in Bicelles Advisor: Dr. Stanley J. Opella 1997 B.S. in Biochemistry University of Wisconsin, Madison, WI. Undergraduate research advisor: Dr. John L. Markley

TRAINING 2008-present Post-doctoral fellowship Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA. Advisors: Drs. Nathalie Scholler, Jerry Glickson & George Coukos. TEACHING 2003 Teaching Assistant Biology 2960: Principles of Biology I. 1999 Teaching Assistant Chemistry 251: Principles of Biological Chemistry.

PRESENTATIONS 2010 Oral and poster presentations: “Targeting of superparamagnetic iron oxide nanoparticles for cancer therapy based on localized hyperthermia” Andrew M. Prantner, Jun Chen, Christopher B. Murray and Nathalie Scholler. 6th annual Symposium Center for Translational Medicine, June 4, Jefferson Medical College, Philadelphia, PA 2009 Key note presentation “Developing a universal method to prepare scFv-modified nanoparticles for ovarian cancer diagnosis and therapy”. Prantner A.M., Glickson J.D., Coukos G. and Scholler N.. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA. 2009 Poster Presentation, “Dual Specificity Suicide Gene Therapy Using Targeted Nanoparticles Directed against Ovarian Cancer”. Andrew M. Prantner, Patricia Ohana, Abraham Hochberg, Jerry D. Glickson, George Coukos and Nathalie Scholler. Biomedical Post Doctoral Research Symposium 2009. University of Pennsylvania, Philadelphia, PA.

A.M. Prantner, CV, page 1 of 3 2009 Oral presentation, “Targeted Nanoparticles Directed against Ovarian Cancer”. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA. 2009 Poster Presentation, “Construction of a large scFv yeast display library and isolation of TEM1- specific antibodies of high affinity for targeted-imaging and therapy of cancer” Zhao ., Li C., Nunez- Cruz S., Prantner A.M., Coukos G., Siegel D.L. and Scholler N. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA. 2009 Poster Presentation, “Development of an orthotopic mouse model of serous ovarian cancer for in vivo imaging” Nunez-Cruz S., Prantner A.M., Zhao A., Roberts A., Secreto A., Connolly D., Danet- Denoyers G., Coukos G. and Scholler N. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA. 2009 Poster Presentation, “Development of a universal method for targeting nanoparticles with functionally intact scFv”. Prantner A.M., Glickson J.D., Coukos G and Scholler N. Translational Research Cancer Center Consortium conference, University of Pennsylvania- March 6-7- Philadelphia, PA 2008 Poster Presentation - Prantner AM, Bretthorst GL, Neil JJ, Garbow JR, Ackerman JJH, “Tissue (brain) water longitudinal relaxation is biexponential” 16th International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition, Toronto, Ontario. 2006 Poster Presentation - Prantner AM, Neil JJ, Bretthorst GL, Ackerman JJH, Kroenke CD, Garbow JR, “Reevaluation of transcytolemmal water exchange in rat brain” Gordon Research Conference: In vivo Magnetic Resonance, South Hadley, MA. 2005 Oral Presentation- Prantner AM, Bretthorst GL, Ackerman JJH, “Compartment-specific water apparent-diffusion coefficients in mammalian brain” 25th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering, San Jose, CA. 1999 Poster Presentation - Prantner AM, Veglia G, Mesleh MF, Opella SJ, “Solid-state NMR studies of membrane proteins in bicelles” 38th Annual Eastern Analytical Symposium and Exposition, Somerset, NJ. 1997 Poster Presentation - Prantner AM, Volkman BF, Hall DJ, King D, Markley JL “Characterization of a self-cleaving peptide involved in picornaviral processing” Keystone Symposia on Molecular and Cellular Biology: Frontiers of NMR in Molecular Biology V, Taos, NM.

P UBLICATIONS 1- Prantner AM, Bretthorst GL, Neil JJ, Garbow JR, and Ackerman JJH, Magnetization transfer induced biexponential longitudinal relaxation, Magn. Reson. Med., 60:555-563 (2008) 2- Bullok K, Gammon ST, Violini S, Prantner AM, Villalobos VM, Sharma V, and Piwnica- Worms D, Permeation peptide conjugates for In vivo molecular imaging applications, Mol. Imaging, 5:1-15 (2006) 3- Prantner AM, Sharma V, Garbow JR, and Piwnica-Worms D. Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets, Mol. Imaging, 2:333-341 (2003) 4- DeSilva TM, Veglia G, Porcelli F, Prantner AM, and Opella SJ, Selectivity in heavy metal- binding to peptides and proteins, Biopolymers, 64:189-197 (2002) 5- Dvorak CMT, Hall DJ, Hill M, Riddle M, Prantner A, Dillman J, Deibel M, and Palmenberg AC, Leader protein of encephalomyocarditis virus binds zinc, is phosphorylated during viral infection, and affects the efficiency of genome translation, Virology, 290:261-271 (2001)

A.M. Prantner, CV, page 2 of 3 6- Veglia G, Porcelli F, DeSilva T, Prantner A, and Opella SJ, The structure of the metal- binding motif GMTCAAC is similar in an 18-residue linear peptide and the mercury binding protein MerP, J. Am. Chem. Soc., 122: 2389-2390 (2000) 7- Prantner AM, Volkman BF, Wilkens SJ, Xia B, and Markley JL, Assignment of 1H, 13C, and 15N signals of reduced Clostridium pasteurianum rubredoxin: oxidation state-dependent changes in chemical shifts and relaxation rates, J. Biomol. NMR, 10:411-412 (1997) 8- Volkman BF, Prantner AM, Wilkens SJ, Xia B, and Markley JL, Assignment of 1H, 13C, and 15N signals of oxidized Clostridium pasteurianum rubredoxin, J. Biomol. NMR, 10:409- 410 (1997)

Abstracts 2010 “Gold nanorods conjugated to tumor-specific antibody for the targeting of ovarian cancer” Kolin C. Hribar, Gregory R. Wiedman, Andrew Prantner, Chaitanya Divgi, and Nathalie Scholler. Senior Design project of undergraduate students in Bioengineering, poster presentation, April 20, University of Pennsylvania, School of Engineering, PA. 2009 “Development of an orthotopic mouse model of serous ovarian cancer for in vivo imaging” Nunez- Cruz S., Prantner A.M., Zhao A., Roberts A., Secreto A., Connolly D., Danet-Denoyers G., Coukos G. and Scholler N. Poster presentation. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA. 2009 “Construction of a large scFv yeast display library and isolation of TEM1-specific antibodies of high affinity for targeted-imaging and therapy of cancer” Zhao ., Li C., Nunez-Cruz S., Prantner A.M., Coukos G., Siegel D.L. and Scholler N. Poster presentation. CRRWH annual retreat, University of Pennsylvania - May 27- Philadelphia, PA.

A.M. Prantner, CV, page 3 of 3