1. Ziraldo C, Gong C, Kirschner DE, Linderman JJ. Strategic Priming with Multiple Antigens

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1. Ziraldo C, Gong C, Kirschner DE, Linderman JJ. Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study. Front Microbiol. 2016 Jan 6;6:1477.

2. Feris EJ, Encinales L, Awad C, Stern JN, Tabansky I et al. High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis. Int J Infect Dis. 2016 Feb;43:21-4.

3. Tzelepis F, Verway M, Daoud J, et al. Annexin1 regulates DC efferocytosis and cross- presentation during Mycobacterium tuberculosis infection. J Clin Invest. 2015 Feb;125(2):752-68.

4. Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev. 2015 Mar;264(1):182-203.

5. Bai X, Shang S, Henao-Tamayo M, et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5111-6.

6. Kim JS, Kang MJ, Kim WS, et al. Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus. Infect Immun. 2015 Apr;83(4):1556-67.

7. Divangahi M. Efferocytosis: Burying cell corpses to regulate tolerance and immunity. Oncotarget. 2015 Jun 20;6(17):14721-2.

8. Espert L, Beaumelle B, Vergne I. Autophagy in Mycobacterium tuberculosis and HIV infections. Front Cell Infect Microbiol. 2015 Jun 2;5:49.

9. Rivas-Santiago CE, Sarkar S, Cantarella P, et al. Air pollution particulate matter alters antimycobacterial respiratory epithelium innate immunity. Infect Immun. 2015 Jun;83(6):2507-17.

10. Lai R, Afkhami S, Haddadi S, Jeyanathan M, Xing Z. Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments. Eur Respir Rev. 2015 Jun;24(136):356-60.

11. von Both U, Kaforou M, Levin M, Newton SM. Understanding immune protection against tuberculosis using RNA expression profiling. Vaccine. 2015 Sep 29;33(40):5289-93.

12. Rao M, Valentini D, Poiret T, et al. B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis. Clin Infect Dis. 2015 Oct 15;61Suppl 3:S225-34. 13. Ignatov DV, Salina EG, Fursov MV, Skvortsov TA, Azhikina TL, Kaprelyants AS. Dormant non- culturable Mycobacterium tuberculosis retains stable low-abundant mRNA. BMC Genomics. 2015 Nov 16;16(1):954.

14. Ly J, Lagman M, Saing T, et al. Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals. J Interferon Cytokine Res. 2015 Nov;35(11):875-87.

15. Etna MP, Giacomini E, Pardini M, et al. Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions. Sci Rep. 2015 Nov 25;5:17078.

16. Kumar SK, Singh P, Sinha S. Naturally produced opsonizing antibodies restrict the survival of Mycobacterium tuberculosis in human macrophages by augmenting phagosome maturation. Open Biol. 2015 Dec;5(12).

17. Khiroya H, Turner AM. The role of iron in pulmonary pathology. Multidiscip Respir Med. 2015 Dec 1;10:34.

18. Niki M, Suzukawa M, Akashi S, et al. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. J Immunol Res.2015;2015:527395.

19. Cambier CJ, Takaki KK, Larson RP, et al. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature. 2014 Jan 9;505(7482):218-22.

20. Siegrist MS, Bertozzi CR. Mycobacterial lipid logic. Cell Host Microbe. 2014 Jan 15;15(1):1-2.

21. Orme I M. A new unifying theory of the pathogenesis of tuberculosis. Tuberculosis (Edinb). 2014 Jan;94(1):8-14.

22. Parandhaman DK, Narayanan S .Cell death paradigms in the pathogenesis of Mycobacterium tuberculosis infection. Front Cell Infect Microbiol. 2014 Mar 5;4:31.

23. Prezzemolo T, Guggino G, La Manna MP, Di Liberto D, Dieli F, Caccamo N. Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis. Front Immunol. 2014 Apr 22;5:180.

24. Ma J, Yang B, Yu S, et al. Tuberculosis antigen-induced expression of IFN-α in tuberculosis patients inhibits production of IL-1β. FASEB J. 2014 Jul;28(7):3238-48.

25. Xu G, Wang J, Gao GF, Liu CH. Insights into battles between Mycobacterium tuberculosis and macrophages. Protein Cell. 2014 Oct;5(10):728-36.

26. Srivastava S, Ernst JD, Desvignes L. Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol Rev. 2014 Nov;262(1):179-92.

27. Yamashiro LH, Oliveira SC, Bafica A. Innate immune sensing of nucleic acids from mycobacteria. Microbes Infect. 2014 Dec;16(12):991-7. 28. Arbues A, Lugo-Villarino G, Neyrolles O, Guilhot C, Astarie-Dequeker C. Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids. Front Cell Infect Microbiol. 2014 Dec 9;4:173.

29. Dey B, Bishai WR. Crosstalk between Mycobacterium tuberculosis and the host cell. Semin Immunol. 2014 Dec;26(6):486-96.

30. Behar SM, Carpenter SM, Booty MG, Barber DL, Jayaraman P. Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus. Semin Immunol. 2014 Dec;26(6):559-77.

31. Moraco AH, Kornfeld H. Cell Death and Autophagy in TB. Semin Immunol. 2014 Dec;26(6):497-511.

32. Meijer AH, van der Vaart M. DRAM1 promotes the targeting of mycobacteria to selective autophagy. Autophagy. 2014;10(12):2389-91.

33. Guirado E, Schlesinger LS. Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease. Front Immunol. 2013 Apr 22;4:98.

34. Bradfute SB, Castillo EF, Arko-Mensah J, Chauhan S, Jiang S, Mandell M, Deretic V. Autophagy as an immune effector against tuberculosis. Curr Opin Microbiol. 2013 Jun;16(3):355-65.

35. Kunnath-Velayudhan S, Porcelli SA. Recent Advances in Defining the Immunoproteome of Mycobacterium tuberculosis. Front Immunol. 2013 Oct 11;4:335.

36. Maziar Divangahi, Samuel M. Behar, Heinz Remold. Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis. Adv Exp Med Biol. 2013;783:103- 20.

37. Sambarey A, Prashanthi K, Chandra N. Mining large-scale response networks reveals ‘topmost activities’ in Mycobacterium tuberculosis infection. Sci Rep. 2013;3:2302.

38. Simeone R, Bobard A, Lippmann J, et al. Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death. PLoS Pathog. 2012 Feb;8(2):e1002507.

39. Boon C, Dick T. How Mycobacterium tuberculosis goes to sleep: the dormancy survival regulator DosR a decade later. Future Microbiol. 2012 Apr;7(4):513-8

40. Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS. Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages. Cell Host Microbe. 2012 May 17;11(5):469-80.

41. Dusthackeer VN, Balaji S, Gomathi NS, Selvakumar N, Kumar V. Diagnostic luciferase reporter phage assay for active and non-replicating persistors to detect tubercle bacilli from sputum samples. Clin Microbiol Infect. 2012 May;18(5):492-6.

42. Zhang Q, Sugawara I. Immunology of tuberculosis. World J Exp Med. 2012 Aug 20;2(4):70-4. 43. Cooper AM, Torrado E. Protection versus pathology in tuberculosis: recent insights. Curr Opin Immunol. 2012 Aug;24(4):431-7.

44. Abebe F.Is interferon-gamma the right marker for bacille Calmette-Guérin-induced immune protection? The missing link in our understanding of tuberculosis immunology. Clin Exp Immunol. 2012 Sep;169(3):213-9.

45. Singh V, Jamwal S, Jain R, Verma P, Gokhale R, Rao KV. Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype. Cell Host Microbe. 2012 Nov 15;12(5):669-81.

46. Silva Miranda M, Breiman A, Allain S, Deknuydt F, Altare F. The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria? Clin Dev Immunol. 2012;2012:139127.

47. Romero MM, Balboa L, Basile JI, et al. Clinical isolates of Mycobacterium tuberculosis differ in their ability to induce respiratory burst and apoptosis in neutrophils as a possible mechanism of immune escape. Clin Dev Immunol. 2012;2012:152546.

48. Zuñiga J, Torres-García D, Santos-Mendoza T, Rodriguez-Reyna TS, Granados J, Yunis EJ. Cellular and humoral mechanisms involved in the control of tuberculosis. Clin Dev Immunol. 2012;2012:193923.

49. Shaler CR, Horvath C, Lai R, Xing Z. Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. Clin Dev Immunol. 2012;2012:628293.

50. Yu Y, Zhang Y, Hu S, Jin D, Chen X, Jin Q, Liu H. Different Patterns of Cytokines and Chemokines Combined with IFN-c Production Reflect Mycobacterium tuberculosis Infection and Disease. PLoS One. 2012;7(9):e44944.

51. Ottenhoff TH, Dass RH, Yang N, et al. Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis. PLoS One. 2012;7(9):e45839.

52. Druszczyńska M, Włodarczyk M, Fol M, Rudnicka W. Recognition of mycobacterial antigens by phagocytes. Postepy Hig Med Dosw (Online). 2011 Jan 25;65:28-39.

53. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011 Feb;30(1):16-34.

54. Schwander S, Dheda K. Human lung immunity against Mycobacterium tuberculosis: insights into pathogenesis and protection. Am J Respir Crit Care Med. 2011 Mar 15;183(6):696-707.

55. Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation. J Immunol. 2011 Mar 15;186(6):3472-83. 56. Commandeur S, van Meijgaarden KE, Lin MY, et al. Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals. Clin Vaccine Immunol. 2011 Apr;18(4):676-83.

57. Kwakernaak AJ, Houtman PM, Weel JF, Spoorenberg JP, Jansen TL. A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor. Clin Rheumatol. 2011 Apr;30(4):505-10.

58. England K, Crew R, Slayden RA. Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response. BMC Microbiol. 2011 Apr 19;11:79.

59. Urdahl KB, Shafiani S, Ernst JD. Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol. 2011 May;4(3):288-93.

60. Behar SM, Martin CJ, Booty MG, Nishimura T, Zhao X, Gan HX, Divangahi M, Remold HG. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol. 2011 May;4(3):279-87.

61. Yang Z, Rosenthal M, Rosenberg NA, et al. How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology. Infect Genet Evol. 2011 Jul;11(5):1164-7.

62. Behar SM, Martin CJ, Nunes-Alves C, Divangahi M, Remold HG. Lipids, apoptosis, and cross- presentation: links in the chain of host defense against Mycobacterium tuberculosis. Microbes Infect. 2011 Aug;13(8-9):749-56.

63. Saiga H, Shimada Y, Takeda K. Innate immune effectors in mycobacterial infection. Clin Dev Immunol. 2011;2011:347594.

64. Welin A, Raffetseder J, Eklund D, Stendahl O, Lerm M. Importance of phagosomal functionality for growth restriction of Mycobacterium tuberculosis in primary human macrophages. J Innate Immun. 2011;3(5):508-18.

65. Kleinnijenhuis J, Oosting M, Joosten LA, Netea MG, Van Crevel R. Innate immune recognition of Mycobacterium tuberculosis. Clin Dev Immunol. 2011;2011:405310.

66. Meraviglia S, El Daker S, Dieli F, Martini F, Martino A. γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. Clin Dev Immunol. 2011;2011:587315.

67. Jordao L, Vieira OV. Tuberculosis: new aspects of an old disease. Int J Cell Biol. 2011;2011:403623.

68. Saiga H, Shimada Y, Takeda K. Innate immune effectors in mycobacterial infection. Clin Dev Immunol. 2011;2011:347594. 69. Sun J, Wang X, Lau A, Liao TY, Bucci C, Hmama Z. Mycobacterial Nucleoside Diphosphate Kinase Blocks Phagosome Maturation in Murine Raw 264.7 Macrophages PLoS One. 2010 Jan 19;5(1):e8769.

70. Xu Y, Eissa T. Autophagy in Innate and Adaptive Immunity. Proc Am Thorac Soc. 2010 Feb;7(1):22-8.

71. Lee J, Kornfeld H. Interferon-γ Regulates the Death of M. tuberculosis-Infected Macrophages. J Cell Death. 2010 Mar 3;3:1-11.

72. Halaas O, Steigedal M, Haug M, et al. Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway. J Infect Dis. 2010 Mar;201(5):783-92.

73. Harding CV, Boom WH. Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors. Nat Rev Microbiol. 2010 Apr;8(4):296-307.

74. Gupta D, Sharma S, Singhal J, Satsangi AT, Antony C, Natarajan K. Suppression of TLR2- induced IL-12, reactive oxygen species, and inducible nitric oxide synthase expression by Mycobacterium tuberculosis antigens expressed inside macrophages during the course of infection. J Immunol. 2010 May 15;184(10):5444-55.

75. Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol. 2010 Jun 14;189(6):925-35.

76. Constantoulakis P, Filiou E, Rovina N, et al. In vivo expression of innate immunity markers in patients with Mycobacterium tuberculosis infection. BMC Infect Dis. 2010 Aug 18;10:243.

77. Khader SA, Gopal R. IL-17 in protective immunity to intracellular pathogens. Virulence. 2010 Sep-Oct;1(5):423-7.

78. Raghuvanshi S, Sharma P, Singh S, Van Kaer L, Das G. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21653-8.

79. Marakalala MJ, Graham LM, Brown GD. The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clin Dev Immunol. 2010;2010:567571.

80. Lee J, Hartman M, Kornfeld H. Macrophage Apoptosis in Tuberculosis. Yonsei Med J. 2009 Feb 28;50(1):1-11.

81. Yoshida A, Inagawa H, Kohchi C, Nishizawa T, Soma G. The role of toll-like receptor 2 in survival strategies of Mycobacterium tuberculosis in macrophage phagosomes. Anticancer Res. 2009 Mar;29(3):907-10. 82. Ehrt S, Schnappinger D. Mycobacterial survival strategies in the phagosome: Defense against host stresses. Cell Microbiol. 2009 Aug;11(8):1170-8.

83. Baena A, Porcelli SA. Evasion and subversion of antigen presentation by Mycobacterium tuberculosis. Tissue Antigens. 2009 Sep;74(3):189-204.

84. Khader SA, Rangel-Moreno J, Fountain JJ, et al. In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity. J Immunol. 2009 Dec 15;183(12):8004-14.

85. Briken V, Miller JL. Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis. Future Microbiol. 2008 Aug;3(4):415-22.

86. Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev. 2008 Mar;72(1):126-56.

87. Lazarevic V, Martinon F. Linking Inflammasome Activation and Phagosome Maturation. Cell Host Microbe. 2008 Apr 17;3(4):199-200.

88. Master SS, Rampini SK, Davis AS, et al. Mycobacterium tuberculosis prevents inflammasome activation. Cell Host Microbe. 2008 Apr 17;3(4):224-32.

89. Deretic V. Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it. Future Microbiol. 2008 Oct;3(5):517-24.

90. Peyron P, Vaubourgeix J, Poquet Y et al. Foamy Macrophages from Tuberculous Patients’ Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence. PLoS Pathog. 2008 Nov;4(11):e1000204

91. Harris J, Hope JC, Keane J. J. Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis. Infect Dis. 2008 Dec 15;198(12):1842-50.

92. Santosuosso M, McCormick S, Roediger E, Zhang X, Zganiacz A, Lichty BD, Xing Z. J Mucosal luminal manipulation of T cell geography switches on protective efficacy by otherwise ineffective parenteral genetic immunization. Immunol. 2007 Feb 15;178(4):2387-95.

93. Saunders BM, Britton WJ. Life and death in the granuloma: immunopathology of tuberculosis. Immunol Cell Biol. 2007 Feb-Mar;85(2):103-11.

94. Iona E, Giannoni F, Pardini M, Brunori L, Orefici G, Fattorini L. Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007 Apr;51(4):1537-40.

95. van Crevel R, Ottenhoff TH, van der Meer JW. Innate immunity to Mycobacterium tuberculosis. Clin Microbiol Rev. 2002 Apr;15(2):294-309.

96. Nicod LP. Immunology of tuberculosis. Swiss Med Wkly. 2007 Jun 30;137(25-26):357-62. 97. Martineau AR, Newton SM, Wilkinson KA, et al. Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest. 2007 Jul;117(7):1988-94.

98. Ernst JD, Trevejo-Nuñez G, Banaiee N. Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis. J Clin Invest. 2007 Jul;117(7):1738-45.

99. Ordway D, Palanisamy G, Henao-Tamayo M, Smith EE, Shanley C, Orme IM, Basaraba RJ. The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig. J Immunol. 2007 Aug 15;179(4):2532-41.

100. Huynh KK, Grinstein S. Regulation of vacuolar pH and its modulation by some microbial species. Microbiol Mol Biol Rev. 2007 Sep;71(3):452- 62.

101.D'Avila H, Melo RC, Parreira GG, Werneck-Barroso E, Castro-Faria-Neto HC, Bozza PT. Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol. 2006 Mar 1;176(5):3087-97.

102. Arias MA, Pantoja AE, Jaramillo G, et al. Chemokine receptor expression and modulation by Mycobacterium tuberculosis antigens on mononuclear cells from human lymphoid tissues. Immunology. 2006 Jun;118(2):171-84.

103. Loeuillet C, Martinon F, Perez C, Munoz M, Thome M, Meylan PR. Mycobacterium tuberculosis subverts innate immunity to evade specific effectors. J Immunol. 2006 Nov 1;177(9):6245-55.

104. Ordway D, Henao-Tamayo M, Orme IM, Gonzalez-Juarrero M. Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family. J Immunol. 2005 Sep 15;175(6):3873-81.

105. Raja A. Immunology of tuberculosis. Indian J Med Res. 2004 Oct;120(4):213-32.

106. Kaufmann SH. New issues in tuberculosis. Ann Rheum Dis. 2004 Nov;63 Suppl 2:ii50-ii56.

107. Cardona PJ, Ruiz-Manzano J. On the nature of Mycobacterium tuberculosis-latent bacilli. Eur Respir J. 2004 Dec;24(6):1044-51.

108. Kaufmann SH. Immune response to tuberculosis: experimental animal models. Tuberculosis (Edinb). 2003;83(1-3):107-11.

109. Seiler P, Ulrichs T, Bandermann S,et al. Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection. J Infect Dis. 2003 Nov 1;188(9):1326-31.

110.Dick T. Dormant tubercle bacilli: the key to more effective TB chemotherapy? J Antimicrob Chemother. 2001 Jan;47(1):117-8. 111. Wayne LG, Hayes LG. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun. 1996 Jun;64(6):2062-9.

112.Wayne LG, Sramek HA. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1994 Sep;38(9):2054-8.