Supplementay Table 2 Parameters Associated Postoperative Ileus and Anastomotic Complicationsa

Supplementay Table 2 Parameters associated postoperative ileus and anastomotic complicationsa

Parametersb 3-year LR, % P-valuec OR 95% CI P-valued

Associated with postoperative ileus Sex, female versus male 38/779 vs. 121/1335 <0.001 1.775 1.092-2.887 0.021

(4.9 vs. 9.1) Procedure, versus APR vs. SSO 104/1095 vs. 55/1019 <0.001 0.856 0.525-1.397 0.534

(6.7 vs. 2.4) Procedure: ULAR, ISR− versus + 70/603 vs. 30/406 0.031 0.64 0.392-1.046 0.075

(11.6 vs. 7.4) Preoperative CRT, no versus yes 78/1328 vs. 81/786 <0.001 0.865 0.449-1.665 0.663

(5.9 vs. 10.3) Ileal diversion, no versus yes 66/1451 vs. 93/663 <0.001 2.603 1.478-4.584 0.001

(4.5 vs. 14) Tumor growth, E versus I 78/1353 vs. 79/737 <0.001 1.107 0.622-1.969 0.729

(5.8 vs. 10.7) CRM, no versus yes 150/2542 vs. 7/39 0.024 2.698 0.701-10.379 0.149

(7.3 vs. 17.9)

Associated with anastomotic complications

Sex, female versus male 30/779 vs. 78/1335 0.051 1.85 1.049-3.263 0.034

(5.8 vs. 3.9) Tumor location, U+M versus L 60/1340 vs. 48/773 0.1 0.98 0.583-1.706 0.943

(4.5 vs. 6.2) Procedure: ULAR, ISR− versus + 35/603 vs. 35/406 0.1 1.503 0.88-2.567 0.136

(5.8 vs. 8.6) PNI, no versus yes 82/1752 vs. 24/319 0.039 1.22 0.603-2.47 0.58

(4.7 vs. 7.5)

Transfusion >400 ml, no versus yes 100/2028 vs. 8/86 0.079 1.621 0.546-4.815 0.384

(4.9 vs. 9.3)

OR, odds ratio; CI, confidence interval; APR, abdominoperineal resection; SSO, sphincter-saving operation;

ULAR, ultra-low anterior resection; ISR, intersphincteric resection; CRT, chemoradiotherapy; E/I,

1 expanding/infiltrative; CRM, circumferential resection margin; U/M/L, upper/middle/lower; PNI, perineural invasion. aAnastomotic complications include leak, abscess, fistula, and stricture. bValues in parentheses are percentages. cAll parameters were compared using Fisher’s exact test with two-sided verification. dPotential variables were verified by multivariate analysis using binary logistic regression.