TABLE S3. Common Gene Signature of Epithelial and Stromal Sps in Human Endometrium

TABLE S3. Common gene signature of epithelial and stromal SPs in human endometrium.

DOWN-REGULATED GENES

Gene Gene Symbol Function Fold Change

Description Von Willebrand VWF Cell-substrate adhesion -3,09 (EPIT)

factor -4,33 (STR) Gap junction GJB1 Cell-cell signalling -3,91 (EPIT) protein, beta 1, Integral to membrane -2,85 (STR)

32kDa Transmembrane TMEM101 Positive regulation of I-KappaB -4,08 (EPIT) protein 101 kinase/NF-KappaB cascade -1,48 (STR)

Integral to membrane

Signal transducer activity THC2624264 -4,15 (EPIT)

-1,84 (STR) Histone cluster 1, HIST1H1A Nucleosome assembly -4,50 (EPIT)

H1a DNA binding -2,29 (STR) V-myc MYCN Regulation of transcription from -4,78 (EPIT) myelocytomatosis RNA polymerase II promoter -1,53 (STR) viral related Protein binding oncogene, neuroblastoma derived (avian) THC2598362 -4,99 (EPIT)

-1,30 (STR) Hemoglobin delta HBD Oxygen transport -5,04 (EPIT)

1 -1,21 (STR) Homeobox B6 HOXB6 Regulation of transcription, -5,55 (EPIT)

DNA-dependent -2,76 (STR) Sp5 transcription SP5 Regulation of transcription, -5,71 (EPIT) factor DNA-dependent -1,48 (STR) FERM domain FRMD4A Binding -5,87 (EPIT) containing 4A -1,66 (STR) Hemoglobin beta HBB Nitric oxide transport -6,48 (EPIT)

Oxygen transport -1,89 (STR)

Positive regulation of nitric oxide

biosynthetic process LOC146325 -7,31 (EPIT)

-1,39 (STR) Proprotein PCSK1N Neuropeptide signalling pathway -11,15 (EPIT) convertase -1,87 (STR) subtilisin/kexin type 1 inhibitor

UP-REGULATED GENES

Gene Description Gene Symbol Function Fold Change Interleukin 1beta IL1B Anti-apotosis +19,82

Negative regulation of cell (EPIT)

proliferation + 4,49 (STR)

Positive regulation of mitosis

Positive regulation of vascular

endothelial growth factor

production Chemokine (C-X- CXCL1 Negative regulation of cell +19,06

C motif) ligand 1 proliferation (EPIT)

2 (melanoma Intracellular signalling cascade + 4,33 (STR) growth stimulating activity, alpha) Heat shock HSPA6 Stress response +16,88

70kDa protein 6 (EPIT)

(HSP70B') + 4,12 (STR) Tubulin alpha-1 TUBA1 Protein polymerization +13,66 chain (EPIT)

+ 1,98 (STR) Growth GDF15 Cell-cell signalling +12,48 differentiation Transforming growth factor beta (EPIT) factor 15 receptor signalling pathway + 5,36 (STR) Adrenomedullin ADM Hormone activity +9,41 (EPIT)

+5,32 (STR) Solute carrier SLC2A14 Cell differentiation +9,30 (EPIT) family 2, Transmembrane transport +2,14 (STR) facilitated glucose transporter member 14 Chemokine (C-C CCL3 Cell-cell signalling +8,90 (EPIT) motif) ligand 3 Cellular calcium ion homeostasis +1,33 (STR)

Cell motion Nuclear receptor NR4A3 Transcription regulation +8,87 (EPIT) subfamily 4, +3,80 (STR) group A, member

3 Amphiregulin AREG Cell-cell signalling +8,63 (EPIT)

3 Cell proliferation +1,76 (STR)

Positive regulation of DNA

regulation Tumor necrosis TNFAIP3 Anti-apotosis +8,52 (EPIT) factor, alpha- Negative regulation of I-KappaB +2,01 (STR) induced protein 3 kinase/NF-KappaB cascade

Ubiquitin-dependent protein

catabolic process Pleckstrin PHLDA2 Apoptosis +8,29 (EPIT) homology-like +3,22 (STR) domain, family

A, member 2

Chemokine (C-X- CXCL2 Chemotaxis +8,08 (EPIT)

C motif) ligand 2 Immune response +2,93 (STR) Inhibin, beta A INHBA Induction of apoptosis +7,92 (EPIT)

Negative regulation of cell cycle +5,67 (STR)

G1/S transition of mitotic cell

Negative regulation of cell

growth Serpin peptidase SERPINB2 Anti-apoptosis +7,27 (EPIT) inhibitor, clade B +6,27 (STR)

(ovalbumin), member 2 Olfactory OR2C3 G-protein coupled receptor +6,89 (EPIT) receptor, family protein signalling pathway +1,72 (STR)

2, subfamily C,

4 member 3 Angiopoietin-like ANGPTL4 Negative regulation of apoptosis +6,68 (EPIT)

4 Cell differentiation +5,82 (STR)

Response to hypoxia Rho family RND3 Cell adhesion +6,34 (EPIT)

GTPase 3 Small GTPase mediated signal +6,41 (STR)

transduction Interleukin 8 IL8 Negative regulation of cell +6,19 (EPIT)

proliferation +4,46(STR)

Cell-cell signalling

Cell adhesion Hairy and HES1 Transcription regulation +5,96 (EPIT) enhancer of split +1,56 (STR)

1 Immediate early IER3 Anti-apoptosis +5,91 (EPIT) response 3 +5,57 (STR) BCL2-related BCL2A1 Anti-apoptosis +5,83 (EPIT) protein A1 +1,69 (STR) Colony CSF2 Positive regulation of DNA +5,62 (EPIT) stimulating factor replication +3,85 (STR)

2 (granulocyte- Positive regulation of Tyrosine macrophage) phosphorylation of Stat5 protein Matrix MMP3 Proteolysis +5,61 (EPIT) metallopeptidase Collagen catabolic process +6,53 (STR)

3 (stromelysin 1, progelatinase) Serine/threonine- PLK3 Cell cycle +5,25 (EPIT) protein kinase Protein amino acid +2,31 (STR)

phosphorylation Solute carrier SLC2A3 Transmembrane transport +5,19 (EPIT)

5 family 2 +2,11 (STR)

(facilitated glucose transporter), member 3

Early growth EGR2 Transcription factor activity +4,96 (EPIT) response 2 (Krox- +2,94 (STR)

20 homolog,

Drosophila) Phorbol-12- PMAIP1 Caspase activation Induction +4,93 (EPIT) myristate-13- apoptosis +1,70 (STR) acetate-induced protein 1 Superoxide SOD2 Oxygen homeostasis +4,90 (EPIT) dismutase 2, Regulation of transcription from +5,18 (STR) mitochondrial RNA polymerase II promoter Early growth EGR3 Regulation of transcription, +4,88 (EPIT) response 3 DNA-dependent +2,33 (STR) GTP binding GEM Cell surface receptor linked +4,79 (EPIT) protein signal transduction +4,08 (STR) overexpressed in Small GTPase mediated signal skeletal muscle transduction Interleukin-4- IL4I1 Oxidation reduction +4,73 (EPIT) induced protein 1 +1,34 (STR) Chemokine (C-C CCL3L3 Negative regulation of cell +4,72 (EPIT) motif) ligand 3- proliferation +1,26 (STR)

6 like 3 Chemotaxis FLJ39575 +4,60 (EPIT)

+3,86 (STR)

Ras-related RRAD Small GTPase mediated signal +4,55 (EPIT) associated with transduction +2,95 (STR) diabetes Interleukin 6 IL6 Negative regulation of cell +4,49 (EPIT)

(interferon, beta proliferation +4,96 (STR)

2) Positive regulation of anti-

apoptosis

Positive regulation of osteoblast

differentiation Heat shock 70 HSPA1A Anti-apoptosis +4,44 (EPIT) kDa protein 1 +1,79 (STR) Cysteine-rich, CYR61 Cell adhesion +4,41 (EPIT) angiogenic Cell proliferation +3,13 (STR) inducer, 61 Regulation of cell growth Interleukin 23, IL23A Tissue remodelling +4,31 (EPIT) alpha subunit p19 +1,98 (STR) SERTA domain SERTAD1 Regulation of transcription, +4,23 (EPIT) containing 1 DNA-dependent +2,63 (STR)

Positive regulation of cell

proliferation

Regulation of cyclin-dependent

protein kinase activity Intercellular ICAM1 Transmembrane receptor activity +4,23 (EPIT) adhesion Cell adhesion +2,87 (STR) molecule 1 Dual specificity DUSP5 Protein tyrosine phosphatase +3,76 (EPIT)

7 phosphatase 5 activity +3,62 (STR) Growth arrest and GADD45A Apoptosis +3,64 (EPIT)

DNA-damage- Cell cycle arrest +2,68 (STR) inducible, alpha DNA repair G-protein EBI2 G-protein coupled receptor +3,55(EPIT) coupled receptor protein signalling pathway +1,24 (STR)