Peripheral and Central Muscle Relaxants, Antiparkinsonics

Programme : GENERAL MEDICINE

Subject : PHARMACOLOGY 1

Abbreviation : FAR/VAB11

Schedule : 30 hours of lectures

45 hours of practicals

Course distribution : 3rd year, 6th semester

Credits : 3

Form : Lectures, practicals

Lectures: Lecturers : MUDr. Jan Strojil, Ph.D. MUDr. Petra Matalová, Ph.D. MUDr. Hana Suchánková, Ph.D. Doc. MUDr. Karel Urbánek, Ph.D. Prof. RNDr. Pavel Anzenbacher, DrSc. Study: Continuous

Theme Hours Lecturer 1 Pharmacology – introduction and terminology 2 Urbánek 2 Mechanisms of drug action, receptor theory 2 Anzenbacher 3 Pharmacokinetics 2 Strojil 4 Drug metabolism, introduction to toxicology 2 Anzenbacher 5 Adverse drug reactions 2 Strojil 6 Drug research and development 2 Strojil 7 Vegetative nervous system 2 Strojil 8 Peripheral and central muscle relaxants, antiparkinsonics 2 Strojil 9 Pharmacology of pain, analgesics 2 Matalová 10 General and local anaesthetics 2 Strojil 11 Introduction to psychopharmacology 2 Matalová 12 Antipsychotics, antidepressants 2 Strojil 13 Anticonvulsants 2 Matalová 14 Drug dependence, drugs of abuse 2 Strojil 15 Theme reserved 2 Urbánek Practicals: Leading teacher: MUDr. Jan Strojil, Ph.D. Study : Continuous

Theme Hours Introduction to practical training; Basic terminology. Pharmacopoeia, drugs names. 1 General principles of drug prescription, patient adherence, non-technical aspects of 3 prescribing. Prescription of factory made drugs; liquid drug formulations; soft formulations 2 3 (ointments, creams, pastes, gels) Solid drug formulations (powders, tablets, suppositories), 3 3 Prescription of controlled drugs. Prescription for children. 4 Parenteral drugs 3 Test I: drug forms, parenteral drugs, prescription (lecture 1, practicals 1-4) Sources of information, drug labels (indications, adverse effects, contraindications, 5 3 precautions, monitoring, …) Drug marketing, guidelines, pharmacovigilance 6 Visit to the university hospital pharmacy 3 Test II: pharmacokinetics, pharmacodynamics, drug development, adverse effects 7 (Lecture 1-5, practical 5) 3 Pharmacodynamics and pharmacokinetics 8 Sympathomimetics and sympatholytics 3 9 Parasympathomimetics and parasympatholytics 3 Test III: drugs affecting autonomic nervous system 10 3 Opioid analgesics 11 Non-steroidal anti-inflammatory drugs 3 Test IV: analgesics, anaesthetics 12 3 Anxiolytics, hypnotics 13 Treatment of neurodegenerative disorders, nootropics 3 14 Credit test (oral examination) 3 15 Credit on the basis of determined conditions 3

Completed by : Credit Participation in at least 13 classes and all tests, 70% average score on Requirements : tests, final oral examination Literature: 1. Rang H.P., Dale M.M., Ritter J.M.: Pharmacology, Churchill Livingstone, Edinburgh 2. Katzung B.G.: Basic and Clinical Pharmacology, Appleton and Lange, Prentice Hall Int., London 3. Levine R.R.: Pharmacology. Drug Actions and Reactions, The Parthenon Publishing Group, London