Publications (John N. Weinstein, M.D., Ph.D.)

1. Weinstein, J.N., and Caplan, S.R.: Charge-mosaic membranes: Enhanced permeability and negative osmosis with a symmetrical salt. Science 1968; 161: 70- 72. 2. Weinstein, J.N., Bunow, B., Yanowitz, I., and Caplan, S.R.: Water transport in charge-mosaic resin membranes. Polymer Preprints. 1968; 9: 1564-1565. 3. Weinstein, J.N., and Caplan, S.R.: Charge-mosaic membranes: Dialytic separation of electrolytes from nonelectrolytes and amino acids. Science 1970; 169: 296-298. 4. Weinstein, J.N., Bunow, B., and Caplan, S.R.: Transport properties of charge- mosaic membranes I. Theoretical considerations. Desalination 1972; 11: 341-377. 5. Gardner, C., Weinstein, J.N., and Caplan, S.R.: Transport properties of charge- mosaic membranes III. Piezodialysis. Desalination 1973; 12: 19-33. 6. Weinstein, J.N., and Caplan, S.R.: The definition of volume flow in the Kedem- Katchalsky description of membrane transport. J. Phys. Chem. 1973; 77: 2710- 2711. 7. Weinstein, J.N., Kalif, D., and Caplan, S.R.: Transport properties of charge- mosaic membranes II. Experimental studies. Desalination 1973; 12: 1-17. 8. Weinstein, J.N., and Caplan, S.R.: Charge-Mosaic Membranes. National Tech. Info. Service, Springfield, Va., 1974. INT-OSW-RDPR-74-987 (300 pages plus summaries). 9. Weinstein, J.N., and Leitz, F.B.: Piezodialysis: A comparison of theoretical treatments. Desalination 1975; 16: 245-247. 10. Weinstein, J.N., and Leitz, F.B.: Electric power from differences in salinity: The dialytic battery. Science 1976; 191: 557-559. 11. Blumenthal, R., Weinstein, J.N., Sharrow, S.O., and Henkart, P.: Liposome- lymphocyte interactions: Saturable sites for transfer and intracellular release of liposome contents. Proc. Natl. Acad. Sci. 1977; 74: 5603-5607. 12. Weinstein, J.N., Yoshikami, S., Henkart, P., Blumenthal, R., and Hagins, W.A.: Liposome-cell interaction: Transfer and intracellular release of a trapped fluorescent marker. Science 1977; 195: 489-492. 13. Blumenthal, R., Weinstein, J.N., and Henkart, P.: Lipid model membrane studies on immune cytotoxic mechanisms. In: Shamoo, A.E. and Miller, M.W. (Eds) Membrane Toxicity. New York: Plenum, 1977; 495-507. 14. Pagano, R., and Weinstein, J.N.: Interactions of liposomes with mammalian cells. Ann. Rev. Biophys. Bioeng. 1978; 7: 435-468. 15. Yatvin, M.B., Weinstein, J.N., Dennis, W.H., and Blumenthal, R.: Use of hyperthermia to promote selective local release of drugs from liposomes. Proceedings of the Conference on Clinical. Prospects for Hypoxic Cell Sensitizers and Hyperthermia. Wisconsin, Madison Printing and Publishing Co., 1978; 105- 112. 16. Weinstein, J.N., Blumenthal, R., Sharrow, S.O., and Henkart, P.: Antibody- mediated targeting of liposomes: Binding to lymphocytes without incorporation of vesicle contents into the cells. Biochim. Biophys. Acta 1978; 509: 272-288.

1 - Weinstein 17. Yatvin, M.B., Weinstein, J.N., Dennis, W.H., and Blumenthal, R.: Design of liposomes for enhanced local release of drugs by hyperthermia. Science 1978; 202: 1290-1293. 18. Dragsten, P.R., Henkart, P., Blumenthal, R., Weinstein, J.N., and Schlessinger, J.: Lateral diffusion of surface immunoglobulin, Thy-l antigen, and a lipid probe in lymphocyte plasma membranes. Proc. Natl. Acad. Sci. 1979; 76: 5163-5167. 19. Leserman, L.D., Weinstein, J.N., Blumenthal, R., Sharrow, S.O., and Terry, W.D.: Binding of antigen-bearing fluorescent liposomes to the murine myeloma tumor MOPC 3l5. J. Immunol. 1979; 122: 585-591. 20. Weinstein, J.N., Magin, R.L, Yatvin, M.B., and Zaharko, D.S.: Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors. Science 1979; 204: 188-191. 21. Wlodawer, A., Segrest, J.P., Chung, B.H., Chiovetti, R., Jr., and Weinstein, J.N.: High density lipoprotein recombinants: Evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Letters 1979; 104: 231-235. 22. Blumenthal, R., Klausner, R.D., and Weinstein, J.N.: Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes. Nature 1980; 288: 333-338. 23. Leserman, L.D., and Weinstein, J.N: Receptor mediated binding and endocytosis of drug-containing liposomes by tumor cells. In: Tom, B.H., and Six, H.R. (Eds) Liposomes and Immunobiology. Amsterdam, Elsevier, 1980; 241-251. 24. Magin, R.L., and Weinstein, J.N.: Selective delivery of drugs in "temperature- sensitive" liposomes. In: Tom, B.H., and Six, H.R. (Eds) Liposomes and Immunobiology. Amsterdam, Elsevier, 1980; 315-325. 25. Blumenthal, R., Klausner, R.D., Weinstein, J.N., Bridges, K., Tsunoo, H., and Ashwell, G.: Voltage-dependent translocation of hepatic binding protein across lipid model membranes. Annals N.Y. Acad. Sci. 1980; 358: 368-369. 26. Guo, L.S.S., Hamilton, R., Goerke, J., Weinstein, J.N., and Havel, R.J.: Interaction of unilamellar liposomes with serum lipoproteins and apolipoproteins. J. Lipid Research 1980; 21: 993-1003. 27. Klausner, R.L., Bridges, K., Tsunoo, H., Blumenthal, R., Weinstein, J.N., and Ashwell, G.: Reconstitution of the hepatic asialoglyco-protein receptor with phospholipid vesicles. Proc. Natl. Acad. Sci. 1980; 77: 5087-5091. 28. Leserman, L.D., Barbet, J., Kourilsky, F.M., and Weinstein, J.N.: Liposomes directed to specific cellular targets by covalently-coupled monoclonal antibody, protein A, and avidin. Nature 1980; 288: 602-604. 29. Leserman, L.D., Weinstein, J.N., Blumenthal, R., and Terry, W.D.: Receptor- mediated endocytosis of antibody-opsonized liposomes by tumor cells. Proc. Natl. Acad. Sci. 1980; 77: 4089-4093. 30. Leserman, L.D., Weinstein, J.N., Moore, J.J., and Terry, W.D.: Specific interaction of myeloma tumor cells with hapten-bearing liposomes containing methotrexate and carboxyfluorescein. Cancer Research 1980; 40: 4768-4774. 31. Ralston, E., Blumenthal, R., Weinstein, J.N., Sharrow, S.O., and Henkart, P.: Lysophosphatidylcholine in liposomal membranes: Enhanced permeability but little effect on transfer of a water-soluble fluorescent marker into human lymphocytes. Biochim. Biophys. Acta 1980; 597: 543-551.

2 - Weinstein 32. Van Renswoude, A.J.B.M., Blumenthal, R., and Weinstein, J.N.: Thin-layer chromatography with agarose gels: A quick, simple method for evaluating liposome size. Biochim. Biophys. Acta. 1980; 595: 151-156. 33. Weinstein, J.N., Magin, R.L., Cysyk, R.L., and Zaharko, D.S.: Treatment of solid Ll2l0 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate. Cancer Research 1980; 40: 1388-1395. 34. Klausner, R.D., Kumar, N., Weinstein, J.N., Blumenthal, R., and Flavin, M.: Interaction of tubulin with phospholipid vesicles I: Association with vesicles at the phase transition. J. Biol. Chem. 1981; 256: 5879-5885. 35. Kumar, N., Klausner, R.D., Weinstein, J.N., Blumenthal, R., and Flavin, M.: Interaction of tubulin with phospholipid vesicles II: Physical changes of the protein. J. Biol. Chem. 1981; 256: 5886-5889. 36. Parker, R.J., Sieber, S.M., and Weinstein, J.N.: The effect of liposome encapsulation of a fluorescent dye on its uptake by the lymphatics of the rat. Pharmacology 1981; 23: 128-136. 37. Pitas, R.E., Innerarity, T.L., Weinstein, J.N., and Mahley, R.W.: Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis 1981; 1: 177-185. 38. Ralston, E., Hjelmeland, L.M., Klausner, R.D., Weinstein, J.N., and Blumenthal, R.: Carboxyfluorescein as a probe for liposome-cell interactions: Effect of impurities, and purification of the dye. Biochim. Biophys. Acta 1981; 649: 133-137. 39. Weinstein, J.N.: Liposomes as "targeted" drug carriers: A physical chemical perspective. Pure and Applied Chemistry 1981; 53: 2241-2254. 40. Weinstein, J.N., Klausner, R.D., Innerarity, T.L., Ralston, E., and Blumenthal, R.: "Phase transition release", a new approach to the interaction of proteins with lipid vesicles: Application to lipoproteins. Biochim. Biophys. Acta 1981; 647: 270-284. 41. Yatvin, M.B., Muhlensiepen, H., Porschen, W., Weinstein, J.N., and Feinendegen, L.E.: Selective delivery of liposome encapsulated cis- dichlorodiammineplatinum (II) by heat: Influence on tumor drug uptake and growth. Cancer Research 1981; 41: 1602-1607. 42. Blumenthal, R., Klausner, R.D., and Weinstein, J.N.: Voltage-dependent changes in a membrane protein: Studies with the asialoglycoprotein receptor. Biophysical Journal 1982; 37: 122-124. 43. Magin, R.L., and Weinstein, J.N.: Delivery of drugs in temperature-sensitive liposomes. In: Gregoriadis, G., Senior, J., and Trouet, A. (Eds) Targeting of Drugs. New York: Plenum, 1982; 203-221. 44. Blumenthal, R., Ralston, E., Dragsten, P., Leserman, L.D., and Weinstein, J.N.: Lipid vesicle-cell interactions: Analysis of a model for transfer of contents from adsorbed vesicles to cells. Membrane Biochemistry 1982; 4: 283-303. 45. Kempf, C., Klausner, R.D., Weinstein, J.N., van Renswoude, J., Pincus, M., and Blumenthal, R.: Voltage-dependent transbilayer orientation of melittin. J. Biol. Chem. 1982; 257: 2469-2476. 46. Weinstein, J.N., Leserman, L.D., Henkart, P.A., and Blumenthal, R.: Antibody- mediated targeting of liposomes. In: Gregoriadis, G., Senior, J., and Trouet, A. (Eds) Targeting of Drugs. New York: Plenum, 1982; 185-202. 47. Klausner, R.D., Berman, M., Blumenthal, R., Weinstein, J.N., and Caplan, S.R.: Compartmental analysis of light-induced proton movement in reconstituted bacteriorhodopsin vesicles. Biochemistry 1982; 21: 3643-3650.

3 - Weinstein 48. Kumar, N., Blumenthal, R., Henkart, M., Weinstein, J.N., and Klausner, R.D.: Aggregation and calcium-induced fusion of phosphatidylcholine vesicle-tubulin complexes. J. Biol. Chem. 1982; 257: 15137-15144. 49. Weinstein, J.N., Leserman, L.D., Henkart, P.A., and Blumenthal, R.: Antibody- mediated targeting of liposomes. In: Gregoriadis, G., Senior, J., and Trouet, A. (Eds) Targeting of Drugs. New York: Plenum, 1982; 185-202. 50. Weinstein, J.N., Blumenthal, R., Kempf, C., van Renswoude, J., and Klausner, R.D.: Charge clusters and the orientation of membrane proteins. J. Membr. Biol. 1982; 66: 203-212. 51. Weinstein, J.N., Parker, R.J., Keenan, A.M., Dower, S.K., Morse, H.C., 3rd, and Sieber, S.M.: Monoclonal antibodies in the lymphatics: Toward the diagnosis and therapy of tumor metastases. Science 1982; 218: 1334-1337. 52. Blumenthal, R., Kempf, C., van Renswoude, J., Weinstein, J.N., and Klausner, R.D.: Voltage-dependent orientation of membrane proteins. J. Cell Biochem. 1983; 22: 55-67. 53. Klausner, R.D., van Renswoude, J., Kempf, C., Blumenthal, R., and Weinstein, J.N.: The folding of ovalbumin: Renaturation in vitro versus biosynthesis in vitro. Biochem. J. 1983; 212: 801-810. 54. Miller, M., Weinstein, J.N., and Wlodawer, A.: Preliminary x-ray analysis of single crystals of ovalbumin and plakalbumin. J. Biol. Chem. 1983; 258: 5864- 5866. 55. Weinstein, J.N., Steller, M.A., Keenan, A.M., Covell, D.G., Key, M.E., Sieber, S.M., Oldham, R.K., Hwang, K.M., and Parker, R.J.: Monoclonal antibodies in the lymphatics: Selective delivery to lymph node metastases of a solid tumor. Science 1983; 222: 423-427. 56. Weinstein, J.N.: Liposomes as drug carriers in cancer therapy. Cancer Treat. Reports, Twenty-fifth Anniversary Issue 1984; 68: 127-135. 57. Weinstein, J.N., and Leserman, L.D.: Liposomes as drug carriers in cancer chemotherapy. Pharmacology and Therapeutics 1984; 24: 207-233. 58. Weinstein, J.N., Steller, M.A., Covell, D.G., Dower, S.K., Segal, D.M., Keenan, A.M., Sieber, S.M., and Parker, R.J.: Use of monoclonal antibodies for diagnosis and therapy of tumor metastases in lymph nodes. Affinity Chromatography and Biological Recognition 1984; 33-42. 59. Blumenthal, R., Kempf, C., Renswoude, J.V., Weinstein, J.N., and Klausner, R.D.: Voltage-dependent orientation of membrane proteins. In: Oxender, D.L. (Ed) Protein Transport and Secretion. New York: Alan R. Liss, 1984; 1-13. 60. Blumenthal, R., Kempf, C., Renswoude, J.V., Weinstein, J.N., and Klausner, R.D.: Voltage-dependent orientation of membrane proteins. In: Oxender, D.L. (Ed) Protein Transport and Secretion. New York: Alan R. Liss, 1984; 1-13. 61. Weinstein, J.N., Ralston, E., Leserman, L.D., Klausner, R.D., Dragsten, P., and Blumenthal, R.: Self-quenching of carboxyfluorescein fluorescence: Uses in studying liposome stability and liposome-cell interaction. In: Gregoriadis, G. (Ed) Liposome Technology, Vol. 3. Boca Raton, FL: CRC Press, 1984; 183-204. 62. Weinstein, J.N., Steller, M.A., Covell, D.G., Holton, O.D., III, Keenan, A.M., Sieber, S.M., and Parker, R.J.: Monoclonal anti-tumor antibodies in the lymphatics. Cancer Treat. Reports, Twenty-fifth Anniversary Issue 1984; 68: 257- 264.

4 - Weinstein 63. Covell, D.G., Steller, M.A., Parker, R.J., and Weinstein, J.N.: Delivery of monoclonal antibodies through the lymphatics: Characterization by compartmental modeling. Computer Applications in Medical Care 1985; 10: 884-888. 64. Klausner, R.D., Blumenthal, R., Innerarity, T., and Weinstein, J.N.: The interaction of apolipoprotein A-I with unilamellar vesicles of L- -dipalmitoyl phosphatidylcholine. J. Biol. Chem. 1985; 260: 13719-13727. 65. Weinstein, J.N., Holton, O.D., Black, C.D.V., Keenan, A.M., Covell, D.G., Spaulding, G.F., Barbet, J., Steller, M.A., Sieber, S.M., Talley, M.J., and Parker, R.J.: Monoclonal antitumor antibodies in the lymphatics. In: Hickey, R.C., and Sunders, G.F., (Eds) 1985 Year Book of Cancer. Chicago, IL: Year Book Medical Publishers, 1985; 264-266. 66. Weinstein, J.N., Keenan, A.M., Holton, O.D., III, Covell, D.G., Sieber, S.M., Black, C.D.V., Barbet, J., and Parker, R.J.: Use of monoclonal antibodies to detect metastases of solid tumors in lymph nodes. In: Ceriani, R.L. (Ed) Monoclonal Antibodies and Breast Cancer. Martinus Nijhof, Boston, 1985; 218-232. 67. Weinstein, J.N., Parker, R.J., Holton, O.D., III, Keenan, A.M., Covell, D.G., Black, C.D.V., and Sieber, S.M.: Lymphatic delivery of monoclonal antibodies: Potential for detection and treatment of lymph node metastases. Cancer Investigation 1985; 3: 85-95. 68. Covell, D.G., Barbet, J., Holton, O.D., III, Black, C.D.V., and Weinstein, J.N.: The pharmacokinetics of monoclonal IgG1, F(ab')2 and Fab' in mice. Cancer Research 46: 3969-3978, 1986. 69. Covell, D.G., Barbet, J., Holton, O.D. III, Black, C.V.D., Keenan, A.M., Sieber, S.M., and Weinstein, J.N.: Global and local factors in the pharmacology of monoclonal antibodies. American Statistical Society Symposium, 1986. 70. Lotze, M.T., Carrasquillo, J.A., Weinstein, J.N., Bryant, G.J., Perentesis, P., Reynolds, J.C., Matis, L.A., Eger, R.R., Keenan, A.M., Hellstrom, I., Hellstrom, K.- E., and Larson, S.M.: Monoclonal antibody imaging of human melanoma: Radioimmunodetection by subcutaneous or systemic injection. Annals of Surgery 1986; 204: 223-235. 71. Weinstein, J.N., Black, C.D.V., Barbet, J., Eger, R.R., Parker, R.J., Holton, O.D., III, Mulshine, J.L., Keenan, A.M., Larson, S.M., Carrasquillo, J.A., Sieber, S.M., and Covell, D.G.: Selected issues in the pharmacology of monoclonal antibodies. In: Tomlinson, E., and Davis, S.S. (Eds) Site-specific Drug Delivery: Cell Biology, Medicinal and Pharmaceutical Aspects. New York: John Wiley, 1986; 81-91. 72. Steller, M.A., Parker, R.J., Covell, D.G., Holton, O.D., III, Keenan, A.M., Sieber, S.M., and Weinstein, J.N.: Optimization of monoclonal antibody delivery via the lymphatics: The dose-dependence. Cancer Research 1986; 46: 1830-1834. 73. Weinstein, J.N., Black, C.D.V., Keenan, A.M., Holton, O.D., III, Larson, S.M., Sieber, S.M., Covell, D.G., Carrasquillo, J., Barbet, J., and Parker, R.J.: Use of monoclonal antibodies for detection of lymph node metastases. In: Reisfeld, R.A., and Sell, S. (Eds) Monoclonal Antibodies in Cancer Therapy. New York: Alan R. Liss, 1986; 473-488. 74. Weinstein, J.N., Blumenthal, R., and Klausner, R.D.: Carboxyfluorescein leakage assay for lipoprotein-liposome interaction. In: Segrest, J.P., and Albers, J.J. (Eds) Methods in Enzymol. Vol. 128, Part A, Academic Press, London, 1986; 657-668. 75. Weinstein, J.N., Holton, O.D., III, Black, C.D.V., Keenan, A.M., Covell, D.G., Spaulding, G.F., Barbet, J., Steller, M.A., Sieber, S.M., Talley, M.J., and Parker, R.J.: Regional delivery of monoclonal antitumor antibodies: Detection and possible treatment of lymph node metastases. Prog. Clin. Biol. Res. 1986; 212: 169-181.

5 - Weinstein 76. Weinstein, J.N., and Leserman, L.D.: Liposomes as drug carriers in cancer chemotherapy. In: Goldman, I.D. (Ed) The International Encyclopedia of Pharmacology and Therapeutics, Vol. 118: Membrane Transport of Anti-neoplastic Agents. New York: Pergamon Press, 1986; 169-194. 77. Eger, R.R., Covell, D.G., Carrasquillo, J., Larson, S.M., Reynolds, J., Abrams, P., Morgan, A.C., Schroff, R., Foon, K., and Weinstein, J.N.: A kinetic model for the biodistribution of an In-111 labeled monoclonal antibody in humans. Cancer Research 1987; 47: 3328-3336. 78. Holton, O.D., III, Black, C.D.V., Parker, R.J., Covell, D.G., Barbet, J., Sieber, S.M., Talley, M.J., and Weinstein, J.N.: Biodistribution of monoclonal IgG1, F(ab')2, and Fab' in mice after intravenous injection: A comparison between anti-B cell (anti-LyB8.2) and irrelevant (MOPC-21) antibodies. J. Immunol. 1987; 139: 3041-3049. 79. Weinstein, J.N.: Liposomes in the diagnosis and treatment of cancer. In: Ostro, M. (Ed) Liposomes. New York: Marcel Dekker, 1987; 277-338. 80. Keenan, A.M., Weinstein, J.N., Carrasquillo, J.A., Bunn, P.A., Jr., Reynolds, J.C., Foon, K.A., Smarte, N.C., Ghosh, B., Fejka, R.M., Larson, S.M., and Mulshine, J.L.: Immunolymphoscintigraphy and the dose-dependence of indium-111-labeled T101 monoclonal antibody in patients with cutaneous T-cell lymphoma. Cancer Research 1987; 47: 6093-6099. 81. Keenan, A.M., Weinstein, J.N., Mulshine, J.L., Carrasquillo, J.A., Bunn, P.A., Jr., Reynolds, J.C., Foon, K.A., Perentesis, P., Ghosh, B., and Larson, S.M.: Evaluation of lymphoma by immunolymphoscintigraphy: Subcutaneous injection of indium-111-labeled T101 monoclonal antibody. J. Nucl. Med. 1987; 28: 42-46. 82. Mulshine, J.L., Keenan, A.M., Carrasquillo, J.A., Walsh, T., Linnoila, R.I., Holton, O.D., Harwell, J., Larson, S.M., Bunn, P.A., and Weinstein, J.N.: Immunolymphoscintigraphy of pulmonary and mediastinal lymph nodes: A new approach to lung cancer imaging. Cancer Research 1987; 47: 3572-3576. 83. Weinstein, J.N., Black, C.D.V., Holton, O.D., III, Covell, D.G., Parker, R.J., Mulshine, J.L., Lotze, M.T., Carrasquillo, J., Eger, R.R., Lewis, A., Larson, S.M., and Keenan, A.M.: Delivery of monoclonal antibodies to lymph nodes via the lymphatics. In: Winkelhake, J.L., and Holcenberg, J.S. (Eds) The Pharmacology and Toxicology of Proteins. New York: Alan R. Liss, 1987; 75-89. 84. Weinstein, J.N., Covell, D.G., Barbet, J., Eger, R.R., Holton, O.D. III, Talley, M.J., Parker, R.J., and Black, C.D.V.: The pharmacology of monoclonal antibodies. In: Bonavida, B., and Collier, R.J. (Eds) Membrane-mediated Cytotoxicity. New York: Alan R. Liss, Inc., 1987; 279-289. 85. Parker, R.J., Weinstein, J.N., Keenan, A.M., Dower, S.K., Steller, M.A., Holton, O.D., and Sieber, S.M.: Targeting of radiolabelled monoclonal antibodies in the lymphatics. Cancer Research 1987; 47: 2073- 2076. 86. Quill, H., Carlson, L., Fox, B.S., Weinstein, J.N., and Schwartz, R.H.: Optimization of antigen presentation to T cell hybridomas by purified Ia molecules in planar membranes: Ia molecule polymorphism determines the antigenic fine specificity of the response to cytochrome c peptides. J. Immunol. Methods 1987; 98: 29-41. 87. Weinstein, J.N., Eger, R.R., Covell, D.G., Black, C.D.V., Mulshine, J., Carrasquillo, J.A., Larson, S.M., and Keenan, A.M. The pharmacology of monoclonal antibodies. Annals N.Y. Acad. Sci. 1987; 507: 199-210. 88. Barbet, J., Black, C.D.V., Holton, O.D., III, and Weinstein, J.N.: Specific toxicity to activated T and B lymphocytes of a ricin A immunotoxin directed against the

6 - Weinstein class I MHC antigen H-2 K. J. Antibody, Immunoconjugates and Radiopharmaceuticals 1988; 1: 169-180. 89. Black, C.D.V., Atcher, R.W., Barbet, J., Brechbiel, M.W., Holton, O.D. III, Hines, J.J., Gansow, O.A., and Weinstein, J.N.: Selective ablation of B lymphocytes in vivo by an alpha emitter, 212bismuth, chelated to a monoclonal antibody. J. Antibody, Immunoconjugates and Radiopharmaceuticals 1988; 1: 43-53. 90. Black, C.D.V., Kroczek, R.A., Barbet, J., Weinstein, J.N., and Shevach, E.M.: Induction of IL-2 receptor expression in vivo: Response to concanavalin A. Cellular Immunol. 1988; 111: 420-432. 91. Weinstein, J.N.: Immunolymphoscintigraphy and other regional applications of monoclonal antibodies. In: Zalutsky, M.R. (Ed) Antibodies in Radiodiagnosis and Therapy. Boca Raton, FL: CRC Press, 1988; 153-167. 92. Borden, E.C., Bradley, E.C., Evans, C.H., Fox, C.F., Metzgar, R.S., Mitchell, M.S., and Weinstein, J.N.: Biotechnology products in cancer therapy. Cancer Research 1988; 47: 223-225. 93. Weinstein, J.N., and Fujimori, K.: Predictive pharmacology of monoclonal antibodies. In: Bannasch, P. (Ed) Cancer Therapy: New Trends. Berlin: Springer- Verlag, 1989; 197-199. 94. Fujimori, K., Covell, D.G., Fletcher, J.E., and Weinstein, J.N.: A modeling analysis of IgG, F(ab')2, and Fab in tumors. Cancer Research 1989; 49: 5656- 5663. 95. Fujimori, K., and Weinstein, J.N.: Pharmacokinetics and organ targeting of monoclonal antibodies. Advances in Immunopharmacology 1989; 4: 127-129. 96. Szebeni, J., Wahl, S.M., Popovic, M., Wahl, L.M., Gartner, S., Fine, R.L., Skaleric, U., Friedman, R.M., and Weinstein, J.N.: Dipyridamole potentiates the inhibition by azidothymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte/macrophages. Proc. Natl. Acad. Sci. USA 1989; 86: 3842-3846. 97. Fujimori, K., Covell, D.G., Fletcher, J.E., and Weinstein, J.N.: A modeling analysis of monoclonal antibody percolation through tumors: A binding site barrier. J. Nucl. Med., 1990; 31: 1191-1198. 98. Weinstein, J.N.: Antibody lymphoscintigraphy. In: Goldenberg, D.M. (Ed) Cancer Imaging with Radiolabeled Antibodies. Kluwer, Boston, 1990, pp. 365-385. 99. Weinstein, J.N., and Fujimori, K.: Antibody-mediated drug delivery. In: J.B. Hooke and G. Poste (Eds) Protein Design and the Development of New Therapeutics and Vaccines. New York: Plenum Press, 1990; 359-370. 100. Viswanadhan, V.N., Weinstein, J.N., and Elwood, P.C.: Secondary structure of the human membrane-associated folate binding protein using a joint prediction approach. J. Biol. Structure and Dynamics 1990; 7: 985-1001. 101. Szebeni, J., Wahl, L.M., Gartner, S., Popovic, M., Parker, R., Black, C., and Weinstein, J.N.: Inhibition of HIV-1 in monocyte/macrophage cultures by 2',3'- dideoxycytidine-5'-triphosphate, free and in liposomes. AIDS Research and Human Retroviruses 1990; 5: 691-702. 102. Weinstein, J.N. and Fujimori, K.. The pharmacokinetics of monoclonal antibodies and derived peptides. In: Sundwall, A. (Ed.) Preclinical Evaluation of Peptides and Recombinant Proteins. Stockholm: Skogs Grafiska AB, 1990; 35-41. 103. Betageri, G.V., Szebeni, J., Hung, K., Wahl, L.M., Corcoran, M., and Weinstein, J.N.: Effect of dipyridamole on transport and phosphorylation of thymidine and

7 - Weinstein azidothymidine in human monocyte/macrophages. Biochemical Pharmacology 1990; 40: 867-870. 104. Viswanadhan, V.N., Ghose, A.K., Szebeni, J., and Weinstein, J.N.: Mapping the binding site of the nucleoside transporter protein: A 3D-QSAR study. Biochim. Biophys. Acta 1990; 1039: 356-366. 105. Ashorn, P., Moss, B., Weinstein, J.N., Chaudhary, V.K., FitzGerald, D.J., Pastan, I., and Berger, E.A.: Elimination of infectious HIV from human T-cell cultures by synergistic action of CD4-pseudomonas exotoxin and reverse transcriptase inhibitors. Proc. Natl. Acad. Sci. 1990; 87: 8889-8893. 106. Bunow, B. and Weinstein, J.N.: Combo: A new approach to the analysis of drug combinations in vitro. Annals N.Y. Acad. Sci. 1990; 616: 490-494. 107. Weinstein, J.N., Schinazi, R.F., Wahl, S.M., Bunow, B., Gartner, S., Popovic, M., Wahl, L.M., Weislow, O.S., and Szebeni, J.: Synergistic drug combinations in AIDS therapy: Dipyridamole-zidovudine in particular and principles of analysis in general. Annals N.Y. Acad. Sci. 1990; 616: 367-384. 108. Szebeni, J., Wahl, S.M., Schinazi, R.F., Popovic, M., Gartner, S., Wahl, L.M., Weislow, O.S., Betageri, G., Fine, R.L., Dahlberg, J.E., Hunter, E., and Weinstein, J.N. Dipyridamole potentiates the activity of zidovudine and other dideoxynucleosides against HIV-1 in cultured cells. Annals N.Y. Acad. Sci. 1990; 616: 613-616. 109. Patel, S.S., Szebeni, J., Wahl, L.M., and Weinstein, J.N. Effect of dipyridamole on transport and phosphorylation of dideoxycytidine and cytidine in human monocyte-macrophages. Antimicrobial Agents and Chemother. 1991; 35: 1250- 1253. 110. Szebeni, J., Patel, S.S., Hung, K., Wahl, L.M., and Weinstein, J.N. The effect of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (Zidovudine) in human mononuclear cells. Antimicr. Agents. Chemother. 1991; 198-200. 111. Szebeni, J. and Weinstein, J.N.: Dipyridamole binding to proteins in human plasma and in tissue culture media. J. Lab. Clin. Med. 1991; 117: 485-492. 112. Mulshine, J.L., Carrasquillo, J.A., Weinstein, J.N., Keenan, A.M., Reynolds, J.C., Herdt, J., Bunn, P.A., Sausville, E., Eddy, J., Cotelingam, J.D., Perentesis, P., Pinsky, C., and Larson, S.M.: Direct intralymphatic injection of radiolabeled 111-In- T101 in patients with cutaneous T-cell lymphoma. Cancer research 1991; 51:.688- 695. 113. Fujimori, K., Fisher, D.R., and Weinstein, J.N.: Integrated microscopic- macroscopic pharmacology of monoclonal antibody radioconjugates: The radiation dose distribution. Cancer Research 1991; 51: 4821-4827. 114. van Osdol, W., Fujimori, K., and Weinstein, J.N. An analysis of monoclonal antibody distribution in microscopic tumor nodules: Consequences of a "binding site barrier." Cancer Research 1991; 51: 4776-4784. 115. Viswanadhan, V.N., Denckla, B., and Weinstein, J.N. A joint prediction algorithm (Q7-JASEP) improves the prediction of protein secondary structure: Application to /  proteins. Biochemistry, 1991; 30: 11164-11172. 116. Szebeni, J., Dieffenbach, C., Wahl, S.M., Venkateshan, C.N., Yeh, A., Popovic, M., Gartner, S., Wahl, L.M., Peterfy, M., Friedman, R.M., and Weinstein, J.N. Induction of interferon- by human immunodeficiency virus type-1 in human monocyte-macrophage cultures. Journal of Virology, 1991; 65: 6362-6364.

8 - Weinstein 117. Reddy, M.R., Viswanadhan, V.N., and Weinstein, J.N.: Relative differences in the binding free energies of HIV1 protease inhibitors: A thermodynamic cycle perturbation approach. Proc. Natl. Acad. Sci. U.S.A., 1991; 88: 10287-10291. 118. Weinstein, J.N., and Bunow, B. COMBO: New concepts and methods for designing and analyzing experiments on combination therapy. In: A L. Goldstein and E. Garaci (Eds), Combination Therapies: Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases. Plenum Press, N.Y., 1992, pp. 29- 38. 119. Hui, T.E., Fisher, D.R., Press, O.W., Eary, J.F., Weinstein, J.N., Badger, C.C., and Bernstein, I.D. Localized beta dosimetry of 131I-labeled antibodies in follicular lymphoma. Medical Physics, 1992; 19: 97-104. 120. Weinstein, J.N, and van Osdol, W. Early intervention in cancer using monoclonal antibodies and other biological ligands: Micropharmacology and the "binding site barrier.". Cancer Research, 1992; 52: 2747s-2751s. 121. Weinstein, J.N., and van Osdol, W. The macroscopic and microscopic pharmacology of monoclonal antibodies. Intl J. Immunopharm., 1992; 14: 457-463. 122. Weinstein, J.N. and van Osdol, W.: Immunolymphoscintigraphy in the diagnosis of lymphoma and solid tumors. Progress in Lymphology 1992; 13: 295-302. 123. Kageyama, S., Weinstein, J.N., Shirasaka, T., Kempf, D.J., Norbeck, D.W., Plattner, J.J., Erickson, J., and Mitsuya, H.: In vitro inhibition of HIV-1 replication by c2 symmetry-based HIV protease inhibitors as single agents or in combination. Antimicr. Agents. Chemother., 1992; 36: 926-933. 124. Juweid, M., Neumann, R., Paik, C., Perez-Bacete, M.J., Sato, J., van Osdol, W., Weinstein, J.N.: Microdistribution of monoclonal antibodies in solid tumors: Effect of the binding site barrier, Cancer Research, 1992; 52: 5144-5153. 125. Weinstein, J.N., Kohn, K.W., Grever, M.R., Viswanadhan, V.N., Rubinstein, L.V., Monks, A., Scudiero, D.A., Welch, L., Koutsoukos, A., Chiausa, A.J., and Paull, K.D. Neural computing in cancer drug development: Predicting mechanism of action. Science, 1992; 258: 447-451. 126. Weinstein, J.N., Rubinstein, L.V., Koutsoukos, A.D., Kohn, K.W., Grever, M.R., Monks, A., Scudiero, D.A., Welch, L., Chiausa, A.J., Fojo, A.T., Viswanadhan, V.N., and Paull, K.D. Neural networks in the discovery of new treatments for cancer and AIDS. Symp. World Congress on Neural Networks, 1993; 1: 111-116. 127. Betageri, G.V., Black, C.D.V., Szebeni, J., Wahl, L.M., and Weinstein, J.N. Fc- receptor mediated targeting of antibody-bearing liposomes to human monocyte/macrophages. J. Pharmacy and Pharmacology, 1993; 45: 48-53. 128. Juweid, M., Sato, J., Paik, C., Onay-Basaran, S.O., Weinstein, J.N., and Neumann, R.: A simple method for affinity purification of labeled monoclonal antibodies. Nuclear Medicine Biology, 1993; 20: 311-316. 129. van Osdol, W.W., Sung, C., Dedrick, R.L., and Weinstein, J.N. A distributed pharmacokinetic model of two-step imaging and treatment protocols: Application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin. J. Nucl. Med., 1993; 34: 1552-1564. 130. Chabner, B.A., Weinstein, J.N., Paull, K.D., and Grever, M.R. Cell line-based screening for new anticancer drugs. In: Banzet, P., Holland, J.F., Khayat, D., and Weil, M. (Eds.) Cancer Treatment, an Update. Paris: Springer-Verlag France, 1994; 10-16. 131. Weinstein, J.N., Neural networks and predictive statistics in drug discovery. Handbook for the International Forum on Advances in Screening Technology and Data Management, 1994; 79-83.

9 - Weinstein 132. Weinstein, J.N., Casciari, J.J., Raghavan, K., Buolamwini, J., and Myers, T.G. Neural networks in the biomedical sciences: A survey of 386 publications since the beginning of 1991. Symp. World Congress on Neural Networks, 1994; 1: 121-126. 133. Weinstein, J.N., Myers, T., Buolamwini, J., Raghavan, K., Viswanadhan, V.N., Licht, J., Rubinstein, L.V., Koutsoukos, A.D., Kohn, Zaharevitz, D., K.W., Grever, M.R., Monks, A., Scudiero, D.A., Chabner, B.A., Anderson, N.L., Paull, K.D. Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's drug discovery program for cancer and AIDS. Stem Cells, 1994; 12: 13-22. 134. Hendrix, C.W., Flexner, C. Szebeni, J., Kuwahara, S., Pennypacker, S., Weinstein, J.N., and Lietman, P.S.: Dipyridamole's effect on zidovudine pharmacokinetics and tolerance in asymptomatic HIV-infected subjects. Antimicrob. Agents and Chemother., 1994; 38: 1036-1040. 135. Koutsoukos, A.D., Rubinstein, L.V., Faraggi, D., Kalyandrug, S., Weinstein, J.N., Paull, K.D., Kohn, K.W., and Simon, R.M. Discrimination techniques applied to the NCI in vitro antitumor drug screen: Predicting biochemical mechanism of action. Statistics in Medicine, 1994; 13: 719-730. 136. Saga, T., Weinstein, J.N., Jeong, J.M., Heya, T., Lee, J.T., Le, Nhat, Paik, C.H., Sung, C., and Neumann, R.D. Two-step targeting of experimental lung metastases with biotinylated antibody and radiolabeled streptavidin. Cancer Research, 1994; 54: 2160-2165. 137. Sung, C., van Osdol, W.W., Saga, T., Neumann, R.D., Dedrick, R.L., and Weinstein, J.N. Steptavidin distribution in metastatic tumors pretargeted with a biotinylated monoclonal antibody: Theoretical and experimental pharmacokinetics, Cancer Research, 1994; 54: 2166-2175. 138. Weinstein, J.N., Myers, T.G., Fan, Y., Paull, K.D., Zaharevitz, D.W., Kohn, K.W., and van Osdol, W.W. An "information-intensive" strategy for drug discovery at the National Cancer institute: The role of neural networks. Symp. World Congress on Neural Networks, 1995; II: 750-753. 139. van Osdol, W.W., Myers, T.G., Paull, K.D., Kohn, K.W., and Weinstein, J.N. Symp. World Congress on Neural Networks, 1995; II: 762-766. 140. Raghavan, K., Buolamwini, J.K., Fesen, M.R., Pommier, Y., Kohn, K.W., and Weinstein, J.N. Three-dimensional QSAR of HIV integrase inhibitors: A comparative molecular field analysis (CoMFA) study. J. Med. Chem., 1995; 38: 890-897. 141. Casciari, J.J., Hollingshead, M., Alley, M., Mayo, J., Malspeis, L., Miyauchi, S., Grever, M.R., and Weinstein, J.N. Growth and chemotherapeutic response of human tumor cells grown as solid in vitro tumors inside hollow fibers. J. Natl. Cancer Inst., 1994; 86: 1846-1852. 142. Chung, K.N., Paik, T.H., Roberts, S., Kim, C.H., Kirassova, M., Weinstein, J.N., Trepel, J.B., and Elwood, P.C. Site-directed mutagenesis of tryptophan residues to conserved hydrophobic residues inhibits the processing of human KB cell folate receptor. Arch. Biochem. and Biophys. 1994; 315: 407-414. 143. van Osdol, W.W., Myers, T.G., Paull, K.D., Kohn, K.W., and Weinstein, J.N. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J. Natl. Cancer Inst., 1994; 86: 1853-1859. 144. Lori, F., Malykh, A., Cara, A., Sun, D., Weinstein, J.N., Lisziewicz, J., and Gallo, R.C. Hydroxyurea as a novel and potent inhibitor of human immunodeficiency virus type 1 replication. Science, 1994; 266: 801-805.

10 - Weinstein 145. Weinstein, J.N. and Myers, T.G. Information resources for liposome research: The drug discovery program of the U.S. National Cancer Institute. J. Liposome Research, 1995; 5: 837-844. 146. Mazumder, A., Raghavan, K., Weinstein, J.N., Kohn, K.W., and Pommier, Y. Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem. Pharmacol., 1995; 49:1165-1170. 147. Chokekjichai, S., Shirasaka, T., Weinstein, J.N., and Mitsuya, H. In vitro anti- HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: Implications for its combined use with AZT or ddI. Antiviral Research, 1995; 28: 25-38. 148. Alvarez, M., Paull, K., Hose, C., Lee, J.-S., Weinstein, J.N., Grever, M., Bates, S., Fojo, T. Generation of a drug resistance profile by quantitation of mdr-1/P- glycoprotein expression in the cell lines of the NCI anticancer drug screen. J. Clinical Investig., 1995; 95: 2205-2214. 149. Saga, T., Neumann, R.D., Heya, T., Sato, J., Kinuya, S., Le, N., Paik, C.H., and Weinstein, J.N.: Targeting cancer micrometastases with monoclonal antibodies: A "binding site barrier." Proc. Natl Acad. Sci. U.S.A., 1995; 92: 8999-9003. 150. Bates, S.E., Fojo, A.T., Weinstein, J.N., Paull, K.D., Myers, T.G., and Chabner, B.A. Molecular targets in the National Cancer Institute Drug Screen. J Cancer Res Clin Oncol., 1995; 121: 495-500. 151. Viswanadhan, V.N., Mueller, G.A., Basak, S.C., and Weinstein, J.N. A new QSAR algorithm combining principal component analysis with a neural network: Application to calcium channel antagonists. NetSci (electronic publication), January, 1996 (http://www.netsci.org/Science/Compchem/feature07.html). 152. Viswanadhan, V.N., Reddy, M.R., Wlodawer, A., Varney, M.D., and Weinstein, J.N. An approach to rapid estimation of relative binding affinities of enzyme inhibitors: Application to peptidomimetic inhibitors for the HIV-1 protease. J. Med. Chem. 1996; 39: 705-712. 153. Casciari, J., Sato, H., Durum, S.K., Fiege, J., Weinstein, J.N. Reference databases of cytokine structure and function. In: Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.) Chemotherapy and Biological Response Modifiers Annual 16. Amsterdam: Elsevier, 1996; 315-346. 154. Weinstein, J.N., Waltham, M.C., and Myers, T.G. Neural networks in drug discovery. Symp. World Congress on Neural Networks, 1996; 1. 155. Casciari, J., Sato, H., Durum, S.K., Fiege, J., and Weinstein, J.N. Tabular lexicon of cytokine structure and function. In: Chabner, B.A. and Longo, D. (Eds.) Cancer Chemotherapy and Biotherapy: Principles and Practice. Philadelphia: Lippincott-Raven, 1996; 787-810. 156. Dearing, M.P., Englee-Miller, M.J., Kratzke, R.A., Kramer, B.S., Chu, E., Weinstein, J.N., Anderson, M., Venzon, D., Mulshine, J.L., and Gazdar, A.F. Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10- deazaaminopterin (10-EDAM) against human lung cancer cell lines, J. Cell. Biochem 1996; 24:165-172. 157. Buolamwini, J., Raghavan, K., Fesen, M.R., Pommier, Y., Kohn, K.W., and Weinstein, J.N. Electrotopological state analysis of flavones as HIV-1 integrase inhibitors. Pharm. Research 1996; 13: 1891-1894, 1996. 158. Shi, L.M., Fan, Y., Myers, T.G., and Weinstein, J.N. Genetic function approximation in the molecular pharmacology of cancer. Symp. Intl. Congress on Neural Networks, 1997; 1-.

11 - Weinstein 159. Li, G., Waltham, M., Unsworth, E., Treston, A., Anderson, N.L., and Weinstein, J.N. Rapid protein identification from two-dimensional polyacrylamide gels by MALDI mass spectrometry. Electrophoresis 1997; 18:391-402. 160. Myers, T.G., Waltham, M., Li, G., Buolamwini, J.K., Scudiero, D.A., Rubinstein, L.V., Paull, K.D., Sausville, E.A., and Anderson, N.L., and Weinstein, J.N. A protein expression database for the molecular pharmacology of cancer. Electrophoresis 1997; 18:647-653. 161. O'Connor, P.M., Jackman, J., Bae, I., Myers, T.G., Fan, S., Scudiero, D.A., Monks, A., Sausville, E.A., Weinstein, J.N., Friend, S., Fornace, A.J., Jr., and Kohn, K.W. Characterization of the p53 tumor suppressor pathway in the NCI anticancer drug screen cell lines and relationships with chemosensitivity, Cancer Research, 1997; 57: 4285-4300. 162. Burke, H.B., Goodman, P.H., Rosen, D.B., Weinstein, J.N., Hellier, J.H., Winchester, D.P., Harrell, F.E., Marks, J.R., Bostwick, D.G., Osteen, R.T., Zincke, H., and Henson, D.E. Improving cancer survival prediction accuracy. Cancer 1997; 79: 857-862. 163. Wosikowski, K., Schuurhuis, D., Johnson, K., Paull, K.D., Myers, T.G., Weinstein, J., and Bates, S.E. Use of EGF receptor, c-erbB2 and TGF gene expression profiles in the National Cancer Institute anticancer drug screen to identify EGF receptor and c-erbB2 pathway inhibitors. J. Natl. Cancer Inst., 1997; 89: 1505- 1515. 164. Weinstein, J.N., Myers, T.G., O'Connor, P.M., Friend, S.H., Fornace, A.J., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini, J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W., Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D. An information-intensive approach to the molecular pharmacology of cancer. Science 1997; 275:343-349. 165. Shi, L.M., Fan, Y., Myers, T.G., Waltham, M., Paull, K.D., and Weinstein, J.N. Mining the anticancer activity database generated by the U.S. National Cancer Institute's drug discovery program using statistical and artificial intelligence techniques, Mathematical Modeling and Scientific Computing 1998; 38:189-199. 166. Shi, L.M., Myers, T.G., Fan, Y., O'Connor, P.M., Paull, K.D., Friend, S.H., and Weinstein, J.N. Mining the National Cancer Institute anticancer drug discovery database: Cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity. Molecular Pharmacology 1998; 53: 241-251. 167. Shi, L.M., Fan, Y., Myers, T.G., Paull, K.D., and Weinstein, J.N. Mining the NCI anticancer drug discovery databases: Genetic function approximation for the quantitative structure-activity relationship study of anticancer ellipticine analogs. J. Chem. Inf. Comput. Sci. 1998; 38: 189-199. 168. Fan, Y., Weinstein, J.N., Kohn, K.W., Shi, L.M., and Pommier, Y. Molecular modeling studies of the DNA - topoisomerase I ternary cleavable complex with camptothecin. J. Med. Chem. 1998; 41: 2216-2226. 169. Weinstein, J.N., Fishing expeditions, Science 1998; 282: 628-629 (letter in Genome issue). 170. Carrier, F., Georgel, P.T., Pourquier, P., Blake, M., Kontny, H.U., Antinore, M.J., Gariboldi, M., Myers, T.G., Weinstein, J.N., Pommier, Y., and Fornace, A.J., Jr. Gadd45, a p53-responsive stress protein, modifies DNA on damaged chromatin. Molec. Cell Biol. 1999; 19: 1673-1685. 171. Fornace, A.J., Jr., Amundson, S.A., Bittner, M., Myers, T.G., Meltzer, P., Weinstein, J.N., and Trent, J. The complexity of radiation stress responses:

12 - Weinstein Analysis by informatics and functional genomics approaches. Gene Expression 1999; 7: 387-400. 172. Tanabe, L., Smith, L.H., Lee, J.K., Scherf, U., Hunter, L., and Weinstein, J.N. MedMiner: An internet tool for filtering and organizing biomedical information, with application to gene expression profiling. BioTechniques. 1999; 27: 1210-1217. 173. Weinstein, J.N., Waltham, M., Reinhold, W., Lee, J.K., Smith, L.H., Andrews, D., Tanabe, L., Zhou, Y., Myers, T.G., Buolamwini, J.K., and Scherf, U. The current revolution in cancer drug discovery: Genomics, proteomics, and bioinformatics. In Fighting against Cancer: Progress and New Hopes, pg 21-36; 2000 [ISSN 1344- 2368]. 174. van Osdol, W.W., Myers, T.G., and Weinstein, J.N. Neural network techniques for the informatics of cancer drug discovery. Methods Enzymol. 2000; 321: 369- 395. 175. Rindflesch, T.C., Tanabe, L., Weinstein, J.N., and Hunter, L. EDGAR: Extraction of drugs, genes and relations from the biomedical literature. Pac. Symp. Biocomput. 2000; 571-528. (refereed) 176. Shi, L.M., Lee, J.K., Fan, Y., Waltham, M., Andrews, D.T., Scherf, U., Paull, K.D., and Weinstein, J.N. Mining and visualizing large anticancer drug discovery databases. J. Chem. Information and Comput. Sci. 2000; 40: 367-379. 177. Lisziewicz, J., Zeng, G., Weinstein, J.N., and Lori, F. Combination gene therapy: Synergistic inhibition of HIV-1 Tat and Rev function by one RNA molecule, Hum. Gene Ther. 2000; 11: 807-815. 178. Weinstein, J.N. and Buolamwini, J.K. Molecular targets in cancer drug discovery: Cell-based profiling. Current Pharmaceutical Design 2000; 6: 473-483. 179. Ross, D.T., Scherf, U., Eisen, M.B., Perou, C.M., Spellman, P., Iyer, V., Jeffrey, S.S., Van de Rijn, M., Waltham, M., Pergamenschikov, A., Lee, J.C.F., Lashkari, D., Shalon, D., Myers, T.G., Weinstein, J.N., Botstein, D., and Brown, P.O. Systematic variation in gene expression patterns in human cancer cell lines. Nature Genetics 2000; 24: 227-235. 180. Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Kohn, K.W., Reinhold, W.C., Myers, T.G., Andrews, D.T., Scudiero, D.A., Eisen, M.B., Sausville, E.A., Pommier, Y., Botstein, D., Brown, P.O., and Weinstein, J.N. A cDNA microarray gene expression database for the molecular pharmacology of cancer. Nature Genetics 2000; 24: 236-244. 181. Weinstein, J.N. Pharmacogenomics: Teaching old drugs new tricks. New England J. Med. 2000; 343: 1408-1409. 182. Hastie, T., Tibshirani, R., Eisen, M., Brown, P., Ross, D., Scherf, U., Weinstein, J.N., Alizadeh, A., Staudt, L., and Botstein, D. Gene shaving: A new class of clustering methods for expression arrays. Technical Report, Statistics Department, Stanford University, 2000 183. Fan, Y., Shi, L.M., Myers, T., Kohn, K.W., Pommier, Y., and Weinstein, J.N. Quantitative structure-antitumor activity relationships of camptothecin analogs: Cluster analysis and genetic algorithm-based studies. J. Med. Chem. 2001; 44:3254-3263. 184. Viswanadhan, V.N., Mueller, G.A., Basak, S.C., and Weinstein, J.N. Comparison of a neural net-based QSAR algorithm (PCANN) with hologram- and multiple linear regression-based QSAR approaches: Application to 1,4-dihydropyridine-based calcium channel antagonists. J. Chem. Inf. Comput. Sci. 2001; 41:505-511. 185. Viswanadhan, V.N., Ghose, A.K., Kiselyov, A., Weinstein, J.N., and Wendeloski, J.J. Knowledge-based approaches for the design of small molecule libraries for

13 - Weinstein drug discovery. In: Ghose, A.K. and Viswanadhan, V.N. (Eds) Combinatorial library design and evaluation for drug discovery: Principles, methods, software tools and applications. Marcel-Dekker, New York 186. Buckner, J.C., Moynihan, T.J., Quinn, D.I., Schlegel, U., Ali-Osman, F., Srivenugopal, K., Sawaya, R., Esteller, M., Herman, J.G., and Weinstein, J.N. The DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents. New England J. Med. 2001; 344:686-688 (commentary). 187. Weinstein, J.N. Searching for pharmacogenomic markers: The synergy between omic and hypothesis-driven research. Disease Markers 2001; 17:77-88. 188. Staunton, J.E., Slonim, D.K., Coller, H.A., Tamayo, P., Angelo, M.J., Park, J., Scherf, U., Lee, J.K., Weinstein, J.N., Mesirov, J.P., Lander, E.S., and Golub, T.R. Chemosensitivity prediction by transcriptional profiling. Proc. Natl. Acad. Sci. U.S.A. 2001; 98:10787-10792. 189. Weinstein, J.N., Scherf, U., Lee, J.K., Nishizuka, S., Gwadry, F., Ajay, Bussey, K., Kim, S., Smith, L.H., Tanabe, L., Richman, S., Alexander, J., Kouros-Mehr, H., Maunakea, A., and Reinhold, W.C. The bioinformatics of Microarray gene expression profiling. Cytometry 2002; 47:46-49. 190. Weinstein, J.N. Searching for pharmacogenomic markers: The synergy between omic and hypothesis-driven research. Disease Markers 2001; 17:77-88. 191. Zhou, Y., Gwadry, F.G., Reinhold, W.C., Miller, L., Smith, L.H., Scherf, U., Liu, E., Kohn, K.W., Pommier, Y., and Weinstein, J.N. Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: Microarray analysis of dose- and time-dependent effects. Cancer Res. 2002; 62:1688-1695. 192. Weinstein, J.N. ‘Omic’ and hypothesis-driven research in the molecular pharmacology of cancer. Current Opinion in Pharmacology 2002; 2:361-365. 193. Blower, P., Jr., Yang, C., Fligner, M.A., Verducci, J.S., Yu, L., Richman, S., and Weinstein, J.N. Pharmacogenomic Analysis: Correlating molecular substructure classes with microarray gene expression data. The Pharmacogenomics Journal (Nature) 2002; 2:259-271. 194. Feng, W., Wang, G., Zeeberg, B.R., Guo, K., Fojo, A.T., Kane, D.W., Reinhold, W.C., Lababidi, S., Weinstein, J.N., Wang, M.D. Development of gene ontology tool for biological interpretation of genomic and proteomic data. Proc. AMIA Symp. 2003; 839. 195. Daoud, S.S., Munson, P.J., Reinhold, W.C., Young, L., Prabhu, V.V., Yu, Q., LaRose, J., Kohn, K.W., Weinstein, J.N., and Pommier, Y. Impact of p53-knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: A pharmacogenomics study. Cancer Res. 2003; 63:2782-2793. 196. Bussey, K.J., Kane, D., Sunshine, M., Narasimhan, S., Nishizuka, S., Reinhold, W.C., Zeeberg, B., Ajay, Weinstein, J.N. MatchMiner: A tool for batch navigation among gene and gene product identifiers. Genome Biol. 2003; 4:R27. 197. Reinhold, W.C., Kouros-Mehr, H., Kohn, K.W., Maunakea, A.K., Lababidi, S., Roschke, A., Stover, K., Alexander, J., Pantazis, P., Miller, L., Liu, E., Kirsch, I.R., Urasaki, Y., Pommier, Y., and Weinstein, J.N. Apoptotic susceptibility of cancer cells selected for camptothecin resistance: Gene expression profiling, functional analysis, and molecular interaction mapping. Cancer Res. 2003; 63:1000-1011. 198. Lee, J.K., Bussey, K.J., Gwadry, F.G., Reinhold, W., Riddick, G., Pelletier, S.L., Nishizuka, S., and Weinstein, J.N. Comparing cDNA and oligonucleotide array data: Concordance of gene expression across platforms for the NCI-60 cancer cells. Genome Biology 2003; 4: R82.

14 - Weinstein 199. Weinstein, J.N., Nishizuka, S., Reinhold, W.C., Bussey, K., Kim, S., Major, S., Lababidi, S., Feng, W., Wang, G., Raffeld, M., Sunshine, M., Narasimhan, S., Zeeberg, B., Wang, M., Lee, J.K., and Kane, D. Cancer drug discovery: Genomics, Proteomics, and Bioinformatics. Molecular Target Therapy of Cancer, Vol. 1, 2004. 200. Zeeberg, B.R., Feng, W., Wang, G., Wang, M.D., Fojo, A.T., Kane, D.W., Reinhold, W.C., Lababidi, S., Bussey, K., Riss, J., Barrett, J.C., and Weinstein, J.N. GoMiner: A resource for biological interpretation of genomic and proteomic data. Genome Biology 2003; 4:R28. 201. Nishizuka, S., Chen, S.-T., Gwadry, F.G., Alexander, J., Scherf, U., Reinhold, W.C., Waltham, M., Charboneau, L., Young, L., Bussey, K.J., Kim, S., Lababidi, S., Lee, J.K., Pittaluga, S., Munson, P.J., Petricoin, E.F., III, Liotta, L.A., Hewitt, S.M., Raffeld, M., and Weinstein, J.N. Diagnostic markers that distinguish colon and ovarian adenocarcinomas: Identification by genomic, proteomic, and tissue array profiling. Cancer Res. 2003;65:5243-5250. 202. Yoshida, A., Urasaki, Y., Waltham, M., Bergman, A-C., Pourquier, P., Rothwell, D.G., Inuzuka, M., Weinstein, J.N., Ueda, T., Appella, E., Hickson, I.D., and Pommier, Y. Human apurinic/apyrimidinic endonuclease (Ape 1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J. Biol. Chem. 2003; 278: 37768-37776. 203. Nishizuka, S., Charboneau, L., Young, L., Major, S., Reinhold, W.C., Waltham, M., Kouros-Mehr, H., Bussey, Lee, J.K., Munson, P.J., Petricoin, E., III, Liotta, L.A., Weinstein, J.N. Proteomic profiling of the NCI60 cancer cell lines using new high density ‘reverse-phase’ lysate microarrays. Proc. Natl. Acad. Sci. 2003; 100: 14229-14234. 204. Weinstein, J.N. and Pommier, Y. Transcriptomic analysis of the NCI-60 cancer cell lines. Comptes Rendus Biology 2003; 326:909-920. 205. Kim, S., Weinstein, J.N., and Grefenstette, J.J. Inference of large-scale topology of gene regulation networks by neural nets. Proc. IEEE International Conference of Systems, Man, and Cybernetics, 2003; 3969-3975. 206. Roschke, A.V., Tonon, G., Gehlhaus, K.S., McTyre, N., Bussey, K.J., Lababidi, S., Scudiero, D.A., Weinstein, J.N., Kirsch, I.R. Karyotypic complexity of the “NCI- 60” drug-screening panel. Cancer Res., 2003; 63: 8634-8647. 207. Weinstein, J.N. Linking drugs and genes: Pharmacogenomics, pharmacoproteomics, bioinformatics, and the NCI-60. In: Brenner, C. and Duggan, D. (Eds.), Oncogenomics: Molecular Approaches to Cancer. , Hoboken, N.J.,: John Wiley & Sons. 2004; 117-137. 208. Weinstein, J.N. Integromic analysis of the NCI-60 cancer cell lines. Breast Disease 2004; 19: 11-22. 209. Zeeberg, B.R.,* Riss, J.*, Kane, D.W., Bussey, K.J., Uchio, E., Linehan, W.M.,Barrett, J.C., Weinstein, J.N. Mistaken identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics. Biomed. Central Bioinformatics 2004; 5: 80. *joint first authors. 210. Kohn, K.W., Riss, J., Aprelikova, O., Weinstein, J.N., Pommier, Y., Barrett, J.C. Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system. Molec. Biol. of the Cell, 2004; Mol Biol Cell. 2004; 15: 3042-3052. 211. Huang, Y., Anderle, P., Bussey, K.J., Barbacioru, C., Shankavaram, U., Dai, Z., Reinhold, W.C., Papp,A., Weinstein, J.N., and Sadee, W. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res. 2004; 64: 4294-4301.

15 - Weinstein 212. Szakacs, G., Annereau, J.-P., Lababidi, S., Shankavaram, U., Arciello, A., Bussey, K.J., Reinhold, W.C., Guo, Y., Kruh, G.D., Reimers, M., Weinstein, J.N., Gottesman, M.M. Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells. Cancer Cell 2004; 6: 129-137. 213. Mulshine, J.L. and Weinstein, J.N. Is the gene expression pattern of lung cancer detected by screening with spiral computed tomography different from that of symptom-detected lung cancer? Clinical Cancer Research 2004; 10: 5973-5974. 214. Annereau, J.-P., Szakacs, G., Tucker, J., Arciello, A., Cardarelli, C., Collins, J., Grissom, S., Zeeberg, B., Reinhold, W.C., Weinstein, J.N., Pommier, Y., Paules, R., and Gottesman, M.M. Analysis of ABC transporter-expression in drug-selected cell lines by a microarray dedicated to multidrug resistance. Molec. Pharmacol. 2004; 66(6): 1397-1405. 215. Aladjem, M.I., Pasa, S., Parodi, S., Weinstein, J.N., Pommier, Y., Kohn, K.W. Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks. Science STKE 2004; 222: pe8. 216. Roschke, A.V., Lababidi, S., Tonon, G., Gehlhaus, K.S., Weinstein, J.N., and Kirsch, I.R. Chromosomal “state” as a potential target for cancer therapy. Proc. Natl. Acad. Sci. U.S.A. 2005; 102: 2964-2969. 217. Lotze, M.T., Wang, E., Marincola, F., Hanna, N., Panelli, M.C., Weinstein, J.N., Perricone, M.A., Shivers, S.C., Bugelski, J., Sauter, G., Burns, C.A., Howell, M., Damle, N., Taylor, L., Godfrey, T., Petricoin, E., Scheibenbogen, C., Whiteside, T.L., and Coukos, G. Identifying Biomarkers and Surrogates of Tumors in Patients, J. Immunother. 2005; 28: 79-119. 218. Stevens, E.V., Nishizuka, S., Antony, S., Reimers, M., Young, L., Munson, P.J., Weinstein, J.N., Kohn, E.C., and Pommier, Y. A novel proteomic approach for predicting cisplatin and Et-743 drug sensitivity. J. Exptl. Med., submitted. 219. Petersen, D., Gadisetti, C., Geoghegan, J., Hilburn, J., Paarlberg, J., Kim, C.H., Munroe, D., Gangi, L. Han, J., Puri, R., Staudt, L., Weinstein, J.N., Barrett, J.C., Green, J., and Kawasaki, E.S. Three microarray platforms: An analysis of their concordance in profiling gene expression. BMC Genomics 2005; 6: 63. 220. Fojo, T., Farrell, N., Ortuzar, W., Tanimura, H., Weinstein, J.N., Myers, T.G. Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations, Crit. Rev. Hematol./Oncol. 2005; 53: 25-34. 221. Zeeberg, B.R., Qin, H., Narasimhan, S., Sunshine, M., Cao, H., Kane, D.W., Reimers, M., Stephens, R.M., Bryant, D., Burt, S.K., Elnekave, E., Hari, D.M., Wynn, T.A., Cunningham-Rundles, C., Stewart, D.M., Nelson, D., and Weinstein, J.N. High-Throughput GoMiner, an “industrial-strength” Gene Ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID), BMC Bioinformatics 2005; 6:168. 222. Reimers, M. and Weinstein, J.N.. Quality assessment of microarrays: Visualization of spatial artifacts and quantitation of regional biases, BMC Bioinformatics 2005; 6:166. 223. Ludwig, J.A. and Weinstein, J.N: Biomarkers in cancer staging, prognosis, and treatment selection. Nature Reviews Cancer 2005; 5: 845-856. 224. Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., Zeeberg, B., Weinstein, J.N., Blume, J., and Darnell, R.B.: Nova regulates brain-specific splicing to shape the synapse, Nature Genetics 2005; 37: 844-852.

16 - Weinstein 225. Staib, F., Robles, A.I., Varticovski, L., Wang, Sirotin, M., Zhurkin, V.B., Hofseth, L.J., Hussain, S.P., Galle, P.R., Zeeberg, B., Weinstein, J.N., and Harris, C.C. The p53 tumor suppressor network microenvironment components of chronic inflammation stress, Cancer Res. 2005; 65; 10255-10264. 226. Bussey, K.J., Chin, K., Lababidi, S., Reinhold, W.C., Kuo, W.-L., Gwadry, F., Ajay, Kouros-Mehr, H., Fridlyand, J., Jain, A., Collins, C., Nishizuka, S., Tonon, G., Roschke, A., Gehlhaus, K., Kirsch, I., Scudiero, D.A., Reimers, M., Gray, J., and Weinstein, J.N.: Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel, Molecular Cancer Therapeutics 2006; 5: 853-867. 227. Major, S.M., Nishizuka, S., Morita, D., Rowland, Sunshine, M., Shankavaram, U., Washburn, F., Asin, D., Kouros-Mehr, H., Kane, D., and Weinstein, J.N. AbMiner: An information resource of validated antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. BMC Bioinformatics 2006;7: 192. 228. Blower, P.E., Cross, K.C., Eichler, G.S., Myatt, G.J., Weinstein, J.N., and Yang, C. Comparison of methods for sequential screening of large compound sets, Comb. Chem. High Throughput Screen 2006; 9: 115-122. 229. Ludwig, J.A., Szakacs, G., Martin, S.E., Chu, B.F., Cardarelli, C., Sauna, Z.E., Caplen, N.J., Fales, H.M., Ambudkar, S.V., Weinstein, J.N., and Gottesman, M.M. Selective toxicity of NSC 73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Research 2006; 66: 4808- 4815. 230. Morin, R.D., Chang, E., Petrescu, A., Liao, N., Griffith, M., Kirkpatrick, R., Butterfield, Y.S., Young, A.C., Stott, J., Barber, S., Babakaiff, R., Dickson, M.C., Matsuo, C., Wong, D., Yang, G.S., Smailus, D.E., Wetherby, K.D., Kwong, P.N., Grimwood, J., Brinkley, C.P. 3rd, Brown-John, M., Reddix-Dugue, N.D., Mayo, M., Schmutz, J., Beland, J., Park, M., Gibson, S., Olson, T., Bouffard, G.G., Tsai, M., Featherstone, R., Chand, S., Siddiqui, A.S., Jang, W., Lee, E., Klein, S.L., Blakesley, R.W., Zeeberg, B.R., Narasimhan, S., Weinstein, J.N., Prange, Pennacchio, C., Myers, R.M., Green, E.D., Wagner, L., Gerhard, D.S., Marra, M.A., Jones, S.J., and Holt, R.A. Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post- tetraploidization transcriptome remodeling, Genome Res. 2006; 16: 796-803. 231. Kohn, K.W., Aladjem, M.I., Weinstein, J.N., Pommier, Y. Molecular interaction maps of bioregulatory networks: a general rubric for systems biology. Mol. Biol Cell 2006; 17: 1-13. 232. Simmons, S., Zeeberg, B.R., Bussey, K.J., Major, S., Nishizuka, S., Kohn, K.W., Aladjem, M., Pommier, Y., Shankavaram, U., Tanabe, L., Smith, L.H., Kim, S., Reimers, M., Kane, D., Weinstein, J.N. Integromic analysis of diverse molecular. databases: The ‘Miner Suite’ of bioinformatic tools, Chance, in press. 233. Pommier, Y., Weinstein, J.N., Aladjem, M.I., Kohn, K.W. Chk2 molecular interaction map and rationale for Chk2 inhibitors, Clinical Cancer Res. 2006; 12: 2657-2661. 234. Ikediobi, O.N., Edkins, S., Stevens, C., O’Meara, S., Bignell, G., Teague, J., Butler, A., Buck, G., Gray, K., Halliday, K., Kosmidou, V., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Widaa, S., Varian, J., Reinhold, W., Weinstein, J.N., Stratton, M.R., Futreal, P.A., and Wooster, R. DNA sequence analysis of 32 known cancer genes in the NCI-60 cell lines. Molecular Cancer Therapeutics, in press. 235. Reinhold, W.C., Reimers, M., Maunakea, A.K., Kim, S., Lababidi, S., Scherf, U., Ziegler, M.S., Steward, C., Kouros-Mehr, H., Cui, H., Bussey, K.J., Chin, K., Gray,

17 - Weinstein J., Dolginow, D., Nishizuka, S., Scudiero, D.A., Pommier, Y., Munroe, D.J., Feinberg, A., and Weinstein, J.N.: E-cadherin in the NCI-60 cancer cells: Integrating DNA methylation status with mRNA and protein expression, DNA copy number, and transcription factors. Cancer Research, submitted. 236. Riss, J., Khanna, C., Koo, S., Gadisetti, V.R., Chandramouli, H., Yang, H., Hu, Y., Kleiner, D.E., Rosenwald, A., Schaefer, C.F., Ben-Sasson, S.A., Yang, L., Powell, J., Kane, D.W., Star, R.A., Aprelikova, O., Bauer, K., Vasselli, J.R., Maranchie, J.K., Kohn, K.W., Zeeberg, B.R., Buetow, K.H., Linehan, W.M., Weinstein, J.N., Lee, M.P., Klausner, R.D., and Barrett, J.C. Cancers as Wounds that Do Not Heal: Similarities and Differences between Renal Regeneration and Renal Cell Carcinoma. Cancer Research 2006; 66: 7216-7224. 237. Lorenzi, P.L., Reinhold, W.C., Rudelius, M., Gunsior, M., Shankavaram, U., Bussey, K.J., Scherf, U., Eichler, G.S., Martin, S.E., Chin, K., Gray, J.W., Kohn, E.C., Horak, I.D., Von Hoff, D.D., Raffeld, M., Goldsmith, P.K., Caplen, N.J., and Weinstein, J.N. Asparagine synthetase as a causal, predictive biomarker for L- asparaginase activity in ovarian cancer cells. Molec. Cancer Therapeutics, in press. 238. Meng, L.-H., Shankavaram, U., Chen, C., Agama, K., Fu, H.-Q., Gonzalez, F.J., Weinstein, J.N., and Pommier, Y. Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the drug’s antiproliferative effect and for induction of histone gamma-H2AX. Cancer Res., in press. 239. Lee, J.K., Havaleshko, D.M., Cho, H.J., Weinstein, J.N., Karpovich, J., Grimshaw, A., and Theodorescu, D. A new strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Nature, submitted. 240. Martin, S.E., Jones, T.L., Thomas, C.L., Lorenzi, P.L., Nguyen, D.A., Runfola, T., Gunsior, M., Weinstein, J.N., Goldsmith, P.K., Lader, E., Huppi, K., and Caplen, N.J. Increased efficiency of synthetic siRNA screens using multiplexed, multi-gene RNA interference in human cells. Nature Methods, submitted. 241. Kahn, A.B., Ryan, M.C., Liu, H.-F., Zeeberg, B.R., Jamison, D.C., Weinstein, J.N. SpliceMiner: A High-Throughput Database Implementation of the NCBI Evidence Viewer for Microarray Splice Variant Analysis. BMC Bioinformatics, submitted. 242. Boersma, B.J., Reimers, M., Yi, M., Ludwig, J.A., Luke, B.T., Stephens, R.M., Yfantis, H.G., Lee, D.H., Weinstein, J.N., and Ambs, S. The stromal gene expression signature is associated with inflammatory breast cancer and disease outcome. J. Natl. Cancer Inst., submitted. 243. Ben-Dor, A, Lipson, D., Tsalenko, A., Baumbusch, L., Barrett, M.M., Weinstein, J.N., Reimers, M., Boressen-Dale, A.-L., Yakhini, Z. Framework for identifying common aberrations in DNA copy number data. RECOMB, submitted. 244. Shankavaram, U., Reinhold, W.C., Nishizuka, S., Major, S., Morita, d., Reimers, M., Chary, K., Scherf, U., Kahn, A., Dolginow, D., Cossman, J., Kaldjian, E., Scudiero, D.A., Petricoin, E., Liotta, L., Lee, J.K., and Weinstein, J.N. Transcript and protein expression profiles of the NCI-60 cancer cell panel: An integromic microarray study. Molecular Cancer Therapeutics, submitted. 245. Weinstein, J.N. Spotlight on molecular profiling: ‘integromic’ analysis of the NCI-60 cancer cell lines. Molecular Cancer Therapeutics, in press. 246. Weinstein, J.N. and Pommier, Y. Connecting genes, drugs, and diseases: Filling

18 - Weinstein the pipelines? Nature Biotechnol., in press. 247. Weinstein, J.N. Molecular targets in the NCI-60 cancer cell lines: A case study in integrative systems biology and pharmacology. Nature Reviews Cancer, submitted (invited).

Bibliography includes 14 publications in Science (10 as first author)

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