Matthew Koshy, MD

MATTHEW KOSHY, M.D. CURRICULUM VITAE

The University of Chicago Duchossois Center for Advanced Medicine 5758 S. Maryland Avenue 9006 Chicago, IL 60637 [email protected]

ACADEMIC APPOINTMENTS UNIVERSITY OF CHICAGO, Chicago, IL Department of Radiation and Cellular Oncology Assistant Professor July 2010- Present

UNIVERSITY OF ILLINOIS, Chicago, IL Department of Radiation Oncology Attending Physician July 2010- Present

EDUCATION UNIVERSITY OF MARYLAND, Baltimore, MD Department of Radiation Oncology Resident Physician in Radiation Oncology July 2006 - June 2010  Chief Resident July 2009 - June 2010

UNIVERSITY OF MARYLAND, Baltimore, MD Department of Medicine Internship in Internal Medicine June 2005 - June 2006

UNIVERSITY OF FLORIDA, Gainesville, FL Doctor of Medicine May 2005

CORNELL UNIVERSITY, Ithaca, NY Bachelor of Arts in Biology May 2001

Awards and Honors:

2001 Summer Research Fellowship at Rockefeller University 2002 NIH Summer Research Fellowship 2005 The John Harrington Tanous award for Research in Cancer 2008 Travel Grant Recipient for 2008 IGRT Symposium awarded by ASTRO 2008 Travel Grant Recipient for 2008 Lynn Sage Breast Cancer Conference 2009 Travel Grant Recipient for 2009 ACRO Conference 2010 Young Oncologist Essay Award Recipient for American Radium Society 2011 Teacher of the Year – Dept of Rad Onc – University of Chicago

MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES: American Society of Therapeutic Radiation Oncology American Society of Clinical Oncology Matthew Koshy, MD

LICENSURES/CERTIFICATIONS Medical License: Illinois (2010 – present) Board Certification: Radiation Oncology, American Board of Radiology

Research as a Co-Investigator;

1. PI: John Villano Protocol ; 020221 “Phase II Study: An Autologous Dendritic Cell Based Therapeutic Vaccine for Newly Diagnosed Glioblastoma Multiforme.”

2. PI: Keith Thulborn, MD, Department of Radiology Protocol # 2006-0470 “Monitoring Brain Tumor Response to Radiation Treatment Using Sodium MR Imaging”

3. PI: Joe Garcia, MD Protocol # 2010-0548 Investigation of Radiation Pneumonitis

4. PI: Damiano Rondelli MD, Department of Hematology/Oncology Protocol # 2009-0251 “Phase I Study of Intensity Modulated Total Marrow Irradiation (IMTMI) in Addition to Fludarabine/ Busulfan Conditioning for Allogenic Transplantation for Advanced Hematologic Malignancies”

PEER REVIEWED PUBLICATIONS

1. Similar Survival with Breast Conservation Therapy or Mastectomy in the Management of Young Women with Early-Stage Breast Cancer. Mahmood U, Morris C, Neuner G, Koshy M, Kesmodel S, Buras R, Chumsri S, Bao T, Tkaczuk K, Feigenberg S. Int J Radiat Oncol Biol Phys. 2012 Jan 31. [Epub ahead of print]

2. Koshy M, Mahmood U, Rich S, Kwok Y. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. Int J Radiat Oncol Biol Phys., 2012 Feb 1;82(2):619-25. Epub 2011 Jan 27

3. Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, Weichselbaum RR, McCarthy BJ. Improved survival time trends for glioblastoma using the SEER 17 population- based registries. J Neurooncol. 2011 Oct 9. [Epub ahead of print]

4. Mahmood U, Koshy M, Goloubeva O, Suntharalingam M. Adjuvant Radiation Therapy for High-Grade and/or Locally Advanced Major Salivary Gland Tumors. Arch Otolaryngol Head Neck Surg. 2011 Oct;137(10):1025-30.

5. Villano JL, Koshy M, Shaikh H, Dolecek TA, McCarthy BJ. Age, gender, and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer. 2011 Sep 13. [Epub ahead of print]

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6. Koshy M. Is Computed Tomography Simulation Associated with Improved Survival or Is This Finding a Result of Confounding Variables? Journal of Clinical Oncology. 2011 Aug 8. [Epub ahead of print]

7. Koshy M, Mahmood U, Rich S, Merchant TE, Regine WF, Kwok Y. Post-operative Radiation Improves Overall Survival in Children younger than 3 years with Intracranial Ependymoma. Journal of Neurooncology. 2011 Dec;105(3):583-90. Epub 2011 Jun 3.

8. Koshy M, Greenwald B, Hausner P, Krasna M, Horiba N, Battafarano R, Burrows W, Suntharalingam M. Long-term Outcomes Following Trimodality Therapy for Esophageal Cancer: Why Histology Matters. American Journal of Clinical Oncology, 2011 Jun;34(3):259- 64.

9. Koshy M, Goloubeva O, Suntharalingam M. The Impact of Neo-adjuvant Treatment on Survival in Stage III Non-small Cell Lung Cancer (NSCLC): Results from the SEER Registry. International Journal of Radiation Oncology * Biology * Physics, 2011 Apr 1;79(5):1388-94.

10. Koshy M, Zhang B, Naqvi S, Liu B, Mohiuddin M. A Novel Technique for Post-Mastectomy Breast Irradiation Utilizing Non-Coplanar Intensity Modulated Radiation Therapy. British Journal of Radiology. 2010 Oct;83(994):874-81.

11. Cheng S, Iannettoni M, Koshy M, Suntharalingam M, Urba S. Squamous Cell Carcinoma of the Esophagus: Treat with How Many Modalities? Current Clinical Practice. Seminars in Oncology. 2009 Dec;36(6):493-7.

12. Koshy M, Rich S, Mohiuddin M. Improved Survival with Radiation Therapy in High-Grade Soft Tissue Sarcomas of the Extremities: A SEER Analysis. International Journal of Radiation Oncology * Biology * Physics, 2010 May 1;77(1):203-9.

13. Koshy M, Zhao F, Garafalo M. Primary MALT Lymphoma of the Gallbladder: Case Report and Review of the Literature. Journal of Gastrointestinal and Liver Diseases. J Gastrointestin Liver Dis. 2008 Jun;17(2):207-10.

14. Koshy M, Paulino A, Mai W, Teh B. Radiation-induced osteosarcomas in the pediatric population. International Journal of Radiation Oncology * Biology * Physics, 2005. Vol. 63(4): 1169-1174.

15. Xian T, Liu Q, Deacon AM, Koshy M, Kriksunov IA, Lei XG, Hao Q, Thiel DJ. Crystal structure of a heat resilient phytase from Aspergillus fumigatus, carrying a phosphorylated histidine. J Mol Biol. 2004 May 28;339(2):437-45.

ABSTRACTS 1. U Mahmood, C Morris, G Neuner, M Koshy, R Buras, S Kesmodel, S Chumsri, T Bao, K Tkaczuk, S Feigenberg. “Equivalent Survival With Breast Conservation Therapy or Mastectomy in the Management of Young Women With Early Stage Breast Cancer”. IJROBP Oct 2011 81: S32 - 33.

2. U Mahmood, C Morris, G Neuner, M Koshy, R Buras, S Kesmodel, S Chumsri, T Bao, K Tkaczuk, S Feigenberg. “Comparing Survival with Breast-Conservation Therapy and Mastectomy in the Management of Young Women with Early-Stage Breast Cancer”. JCO 2011; 27: S85.

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3. U Mahmood, A Hanlon, M Koshy, R Buras, S Chumsri, K Tkaczuk, S Cheston, W Regine, S Feigenberg. “Early Evidence of Increasing National Mastectomy Rates for the Treatment of Breast Cancer”. J Clin Oncol 2011; 27: S136.

4. Koshy M, J. L. Villano, T. A. Dolecek, A. Howard, S. Chmura, R. R. Weichselbaum, B. J. McCarthy. Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Clin Oncol 29: 2011 (suppl; abstr 2013)

5. U Mahmood, M Koshy, A Hanlon, RBuras, K Tkaczuk, S Feigenberg. Local therapy in the management of occult primary breast cancer. IJROBP Nov 2010(volume 78 issue 3 Pages S159-S160) .

6. C.E. Rutter, S.A. Naqvi, B. Zhang, K. Marter, M. Koshy, A. Dhople, S.J. Feigenberg, W.D. D'Souza. Heterogeneity Corrections Alters the Delivered Dose, Potentially Impacting Complications in Patients Treated with Stereotactic Body Radiotherapy (SBRT) of the Lung. IJROBP Nov 2010 (volume 78 issue 3 Pages S513-S514)

7. M. Koshy, U. Mahmood, S. Rich, Y. Kwok. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. IJROBP (volume 78 issue 3 Pages S65-S66)

8. G.J. Kim, M. Koshy, M.N. Horiba, M.J. Edelman, L.A. Doyle, W.M. Burrows, R.J. Battafarano, M.J. Krasna, A.L. Hanlon, M. Suntharalingam. The Benefit of Adjuvant Chemotherapy in Esophageal Cancer Patients with Residual Disease following Trimodality Therapy. IJROBP November 2010 (volume 78 issue 3 Pages S72-S73)

9. Mahmood U, Goloubeva O, Koshy M, Mohiuddin M, Dhople A. Evaluation of Adjuvant Radiation Therapy in the Management of Male Breast Cancer: A SEER Analysis. American Radium Society 2010.

10. Koshy M, Mahmood U, Rich S, Kwok Y. What is the role of Radiation Therapy in Early Stage Hodgkins Disease? American Radium Society 2010.

11. Koshy M, Rich S, Merchant TE, Regine WF, Kwok Y. Post-operative Radiation Improves Overall Survival in Children Age < 3 years with Intracranial Ependymoma. ASTRO 2009.

12. Mahmood U, Goloubeva O, Koshy M, Suntharalingam M. Adjuvant Radiation is Associated with Improved Survival in High-Grade and Locally Advanced Malignant Major Salivary Gland Tumors: A Surveillance, Epidemiology, and End Results Analysis. ASTRO 2009.

13. Naqvi S, Zhang B, Marter K, D'Souza G, Koshy M, Dhople A, D'Souza WD. Retrospective Dosimetric Evaluation of Heterogeneity Corrections in Lung SBRT Treatments. ASTRO 2009.

14. Koshy M, Rich S, Mohiuddin M. Improved Survival with Radiation Therapy in High-Grade Soft Tissue Sarcomas of the Extremities: A SEER Analysis. American Radium Society 2009.

15. Koshy M, Goloubeva O, Suntharalingam M. The Impact of Neo-adjuvant Treatment on Survival in Stage III Non-small Cell Lung Cancer (NSCLC): Results from the SEER Registry. International Journal of Radiation Oncology * Biology * Physics 1 September 2008 Vol. 72, Issue 1, Page S465

16. Koshy M, Battafarano R, Burrows W, Krasna M, Greenwald B, Mannuel H, Suntharalingam M. Predicting patterns of failure in esophageal cancer following tri-modality therapy: Why histology matters. J Clin Oncol (S) 2008 26: 4553.

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17. Koshy M, Zhang B, Mohiuddin M. Differential Dose Distribution (D3) Utilizing Non-coplanar IMRT in the Post-Mastectomy Setting. Miami Breast Cancer Conference 2008

18. Flannery T, Krasna M, Nichols E, Doyle L, Burrows W, Koshy M, Bardos J, Suntharalingham. The Role of Trimodality Therapy for Patients With Stage IV Esophageal Cancer. International Journal of Radiation Oncology * Biology * Physics. 2007 Vol. 69(3) Pages S271-S272.

19. Koshy M, Naqvi S, Zhang B, Mohiuddin M. Non-Coplanar IMRT for Post-Mastectomy Breast Patients. International Journal of Radiation Oncology * Biology * Physics, 2007 Vol. 69(3) Page S216.

20. Koshy M, Flannery T, Maani E, Burrows W, Dhople A, Doyle L, Krasna M, Suntharalingham M. The Impact of Pathologic Response on Long-Term Outcomes in Patients Treated With Trimodality Therapy for Esophageal Cancer. International Journal of Radiation Oncology * Biology * Physics, 2007. Vol. 69(3) Pages S269-S270.

21. Koshy M, Morris CG, Mendenhall NP. Long-Term Outcomes in Patients with Intermediate- Risk Hodgkin′s Disease Treated with ≤3 Cycles of Chemotherapy followed by Subtotal Nodal Irradiation. International Journal of Radiation Oncology * Biology * Physics. 2005, Vol. 63 Page S435.

22. Koshy M, Mai W, Paulino A. Radiation-induced osteosarcomas in the pediatric population. American Radium Society 2005.

23. Koshy M, Morris CG, Mendenhall NP. Improved outcomes after stereotactic radiotherapy for craniopharyngioma. International Journal of Radiation Oncology*Biology*Physics, 2004. Vol. 60(1), Page S310.

PEER REVIEWED NATIONAL/INTERNATIONAL PRESENTATIONS

1. U Mahmood, C Morris, G Neuner, M Koshy, R Buras, S Kesmodel, S Chumsri, T Bao, K Tkaczuk, S Feigenberg. “Equivalent Survival With Breast Conservation Therapy or Mastectomy in the Management of Young Women With Early Stage Breast Cancer”. Oral presentation. ASTRO, Miami, FL, October 2011.

5. Koshy M, U. Mahmood, S. Rich, Y. Kwok. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. Oral Presentation at ASTRO 2010, San Diego, CA

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6. Koshy M, Rich S, Kwok Y. What is the role of Radiation Therapy in Early Stage Hodgkins Disease? Oral Presentation at 91st Annual Meeting of the American Radium Society, Cancun, Mexico, May1st-5th, 2010.

7. Koshy M, Rich S, Merchant TE, Regine WF, Kwok Y. Post-operative Radiation Improves Overall Survival in Children Age < 3 years with Intracranial Ependymoma. Poster Presentation at 51st Annual Meeting of ASTRO. Chicago, IL October 31 – November 6th, 2009

8. Koshy M, Rich S, Mohiuddin M. Improved Survival with Radiation Therapy in High-Grade Soft Tissue Sarcomas of the Extremities: A SEER Analysis. Oral Presentation at 90th Annual Meeting of the American Radium Society, Vancouver, Canada, April 25-29, 2009.

9. Koshy M, Goloubeva O, Suntharalingam M. The Impact of Neo-adjuvant Treatment on Survival in Stage III Non-small Cell Lung Cancer (NSCLC): Results from the SEER Registry. Poster Presentation at 50thAnnual Meeting of ASTRO. Boston, MA September 21-24, 2008.

10. Koshy M, Battafarano R, Burrows W, Krasna M, Greenwald B, Mannuel H, Suntharalingam M. Predicting patterns of failure in esophageal cancer following tri-modality therapy: Why histology matters. Poster Presentation at ASCO Annual Meeting, Chicago, IL. May 30 - June 2, 2008.

11. Koshy M, Zhang B, Mohiuddin M. Differential Dose Distribution (D3) Utilizing Non-coplanar IMRT in the Post-Mastectomy Setting. Poster Presentation at Miami Breast Cancer Conference. Orlando, FL. Mar. 7-10, 2008.

12. Koshy M, Naqvi S, Zhang B, Mohiuddin M. Non-Coplanar IMRT for Post-Mastectomy Breast Patients. Poster Presentation at ASTRO’s 49th Annual Meeting. Los Angeles, CA. Oct. 27-31, 2007.

13. Koshy M, Flannery T, Maani E, Burrows W, Dhople A, Doyle L, Krasna M, Suntharalingham M. The Impact of Pathologic Response on Long-Term Outcomes in Patients Treated With Trimodality Therapy for Esophageal Cancer. Poster Presentation at ASTRO’s 49th Annual Meeting. Los Angeles, CA. Oct. 27-31, 2007.

14. Koshy M, Morris CG, Mendenhall NP. Long-Term Outcomes in Patients with Intermediate-Risk Hodgkin′s Disease Treated with ≤3 Cycles of Chemotherapy followed by Subtotal Nodal Irradiation. Poster Presentation at 47th Annual Meeting of ASTRO , Denver, CO, October 16-20, 2005

15. Koshy M, Mai W, Paulino A. Radiation-induced osteosarcomas in the pediatric population. Oral Presentation at the 87th Annual Meeting of the American Radium Society, Barcelona, Spain, April 30-May 4, 2005.

16. Koshy M, Morris CG, Mendenhall NP. Improved outcomes after stereotactic radiotherapy for craniopharyngioma. Poster Discussion at 46th Annual meeting of ASTRO. Atlanta, GA, Oct. 3 – 7, 2004.

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