Dr Jake Powrie's Publications

Professor Lucy Chappell’s publications

Original research

1. Bramham K, Seed PT, Lightstone L, Nelson-Piercy C, Gill C, Webster P, Poston L, Chappell LC. Diagnostic and predictive biomarkers for superimposed pre-eclampsia. Kidney Int 2016 Jan 19. pii: S0085- 2538(15)00127-1. doi: 10.1016/j.kint.2015.10.012. 2. Burke O, Benton S, Szafranski P, von Dadelszen P, Buhimschi SC, Cetin I, Chappell L, Figueras F, Galindo A, Herraiz I, Holzman C, Hubel C, Knudsen U, Kronborg C, Laivuori H, Lapaire O, McElrath T, Moertl M, Myers J, Ness RB, Oliveira L, Olson G, Poston L, Ris-Stalpers C, Roberts JM, Schalekamp-Timmermans S, Schlembach D, Steegers E, Stepan H, Tsatsaris V, van der Post JA, Verlohren S, Villa PM, Williams D, Zeisler H, Redman CWG, Staff AC, for the Global Pregnancy Collaboration. Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms. Preg Hypertens 2016; 53–59. http://dx.doi.org/10.1016/j.preghy.2015.12.002 3. Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJ, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology 2015. doi: 10.1002/hep.28265. 4. Cauldwell M, Chappell LC, Murtagh G, Bewley S. Learning about maternal death and grief in the profession: a pilot qualitative study. Acta Obstet Gynecol Scand. 2015. doi: 10.1111/aogs.12760. 5. Griffin, M, Seed P, Webster L, Myers, J, MacKillop, L, Simpson, N, Anumba, D, Khalil, A, Denbow, M, Sau A, Hinshaw K, von Dadelszen, P, Benton S, Girling J, Redman C, Shennan A, Chappell LC. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundal height measurement. Ultrasound Obstet Gynecol. 2015 doi: 10.1002/uog.14860. 6. Nathan HL, de Greeff A, Hezelgrave NL, Chappell LC, Shennan AH. Accuracy Validation of the Microlife 3AS1- 2 Blood Pressure Device in a Pregnant Population with Low Blood Pressure. Blood Press Monit. 2015; 20(5):299-302. doi: 10.1097/MBP.0000000000000134. 7. Oteng-Ntim E, Meeks D, Seed PT, Webster L, Howard J, Doyle P, Chappell LC. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis. Blood 2015. pii: blood-2014-11-607317. 8. Nathan HL, de Greeff A, Hezelgrave NL, Chappell LC, Shennan AH. An accurate semiautomated oscillometric blood pressure device for use in pregnancy (including pre-eclampsia) in a low-income and middle-income country population: the Microlife 3AS1-2. Blood Press Monit. 2015; 20:52-5. doi: 10.1097/MBP.0000000000000086. 9. Van Oostward MF, Langenveld J, Schuit E, Papatsounis D, Brown MA, Byaruhanga RN, Bhattacharya S, Campbell DM, Chappell LC, Chiaffarino F, Crippa I, Facchinetti F, Ferrazzani S, Ferrazzi E, Figueiro-Filho EA, Gaugler-Senden IP, Haavaldsen C, Lykke JA, Mbah AK, Oliveira VM, Poston L, Redman CW, Salim R, Thilaganathan B, Vergani P, Zhang J, Steegers E, Mol BW, Ganzevoort W. Recurrence of hypertensive disorders of pregnancy, an Individual Patient Data Meta-Analysis. Am J Obstet Gynecol 2015. pii: S0002- 9378(15)00010-1. doi: 10.1016/j.ajog.2015.01.009. 10. Mistry HD, Gill C, Kurlak LO, Seed PT, Hesketh JE, Meplan C, Schomburg L, Chappell LC, Morgan L, Poston L. Association between maternal micronutrient status, antioxidant activity and oxidative stress markers at 15 weeks gestation in low-risk, nulliparous women who subsequently develop pre-eclampsia. Free Rad Biol Med. 2015; 78:147-55. doi: 10.1016/j.freeradbiomed.2014.10.580. 11. Bick DE, Beake S, Chappell L, Ismail KM, McCance DR, Green JS, Taylor C. Management of pregnant and postnatal women with pre-existing diabetes or cardiac disease using multi-disciplinary team models of care: a systematic review. BMC Pregnancy Childbirth. 2014;14(1):428.

1 of 5 12. Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ 2014; 348:g2301. doi: 10.1136/bmj.g2301. 13. Hall M, Chappell LC, Parnell BL, Seed PT, Bewley S. Associations between Intimate Partner Violence and Termination of Pregnancy: A Systematic Review and Meta-Analysis. PLoS Med 2014; 11: e1001581. doi:10.1371/journal.pmed.1001581. 14. Geenes V, Chappell LC, Seed PT, Steer P, Knight M, Williamson C. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014; 59:1482-91. doi: 10.1002/hep.26617. 15. Geenes V, Lövgren-Sandblom A, Benthin L, Lawrance D, Chambers J, Gurung V, Thornton J, Chappell L, Khan E, Dixon P, Marschall H-U, Williamson C. The Reversed Feto-Maternal Bile Acid Gradient in Intrahepatic Cholestasis of Pregnancy is Corrected by Ursodeoxycholic Acid. PLoS One 2014; 9: e83828. doi: 10.1371/journal.pone.0083828. 16. Chappell LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny L, Redman C, Shennan AT. Diagnostic accuracy of Placental Growth Factor in women with suspected preeclampsia: a prospective multicentre study. Circulation 2013; 128:2121-31. doi: 10.1161/CIRCULATIONAHA.113.003215. 17. Chappell LC, Seed PT, Myers J, Taylor R, Kenny L, Dekker G, Walker H, McCowan L, North R, Poston L. Exploration and confirmation of factors associated with uncomplicated pregnancy in nulliparous women: prospective cohort study. BMJ 2013; 347: f6398. doi: http://dx.doi.org/10.1136/bmj.f6398. 18. Bramham K, Poli-de-Figueiredo C, Seed, PT, Briley AL, Poston L, Shennan AH, Chappell LC. Association of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case control cohort of high risk women. PLoS One 2013; 8:e76083. doi: 10.1371/journal.pone.0076083. 19. Cutler J, Chappell LC, Kyle P, Madan B. Third trimester amniocentesis for diagnosis of inherited bleeding disorders prior to delivery. Haemophilia 2013; 19:904-7. doi: 10.1111/hae.12247. 20. Mistry HD, Bramham K, Weston AJ, Ward MA, Thompson AJ, Chappell LC. Urine protein concentration estimation for biomarker discovery. Preg Hypertension 2013; 3:211-4. doi:10.1016/j.preghy.2013.07. 21. Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ 2012; 344:e3799. 22. Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011. 94: 6 Suppl 1980S-1985S. 23. Chandiramani M, Chappell L, Radford S, Shennan A. Successful pregnancy following mid-trimester evacuation through a transabdominal cervical cerclage. BMJ Case Rep. 2011. pii: bcr0220113841.. doi: 10.1136/bcr.02.2011.3841. 24. Carty DM, Siwy J, Brennand J, Zürbig P, Mullen W, Franke J, McCulloch JW, North R, Chappell LC, Mischak H, Poston L, Dominiczak A, Delles C. Urinary proteomics for prediction of pre-eclampsia. Hypertension 2011 57(3):561-9. 25. Bramham K, Briley A, Seed PT, Poston L, Shennan AH, Chappell LC. Adverse Maternal and Perinatal Outcomes in Women with Previous Preeclampsia: A Prospective Study. AJOG 2011; 204:512.e1-9.

26. Bramham K, Briley A, Seed PT, Poston L, Shennan AH, Chappell LC. Pregnancy Outcome in Women with Chronic Kidney Disease: a prospective cohort study. Reprod Sci 2011; 18:623-30.

27. Webster J, Chappell L, Cheng F, Breeze A, Lucas N, Plaat F, Williamson C. Operative delivery rates are not increased following induction of labour in women with obstetric cholestasis. Obstetric Medicine 2011; 4: 66–69. doi: 10.1258/om.2011.100080. 28. Seed P, Chappell LC, Black MA, Poppe KK, Hwang Y-C, Kasabov N, McCowan L, Shennan A, Wu, SH, Poston L, North R. Prediction of preeclampsia and delivery of small for gestational age babies based on a combination of clinical risk factors in high-risk women. Hypertens Pregnancy 2011; 30:58-73. 29. McCowan LME, Roberts CT, Dekker GA, Taylor RS, Chan EHY, Kenny LC, Baker PN, Moss-Morris R, Chappell LC, North R. Risk factors for infants small for gestational age by customised birthweight centiles: data from an international prospective cohort study. BJOG 2010; 117(13):1599-607.

2 of 5 30. Chappell LC, Seed P, Enye S, Briley AL, Poston L, Shennan AH. Clinical and geographic variation in prophylactic and therapeutic treatments for pre-eclampsia in the UK. BJOG 2010; 117(6):695-700. 31. Chappell LC. A critical analysis and appraisal of two papers from the educational literature: a story of turning a petroleum engineer into an explorer? Higher Education Research Network Journal 2010; 1:69-74. 32. McCowan LM, Dekker GA, Chan E, Stewart A, Chappell LC, Hunter M, Moss-Morris R, North RA; SCOPE consortium. Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study. BMJ 2009; 338:b1081. 33. Chappell LC, Enye S, Seed P, Briley AL, Poston L, Shennan AH. Adverse Perinatal Outcomes and Risk Factors for Pre-eclampsia in Women with Chronic Hypertension. A Prospective study. Hypertension 2008;51:1002- 9. 34. Barigye O, Pasquini L, Chappell L, Vanderheyden T, Wimalasundera R, Fisk N. Interstitial laser for fetal reduction in complicated monochorionic multiple pregnancy. Prenatal Diagnosis 2008; 28:535-43. 35. Pasquini L, Wimalasundera R, Fichera A, Barigye O, Chappell L, Fisk NM. High perinatal survival in monoamniotic twins managed by prophylactic sulindac, intensive ultrasound surveillance, and caesarean delivery at 32 weeks. Ultrasound Obstet Gynecol 2006; 28:681-7. 36. Barigye O, Pasquini L, Galea P, Chambers H, Chappell L, Fisk NM. High risk of unexpected late fetal death in monochorionic twins despite intensive ultrasound surveillance: a cohort study. PloS Med 2005; 2(6):e172. 37. Goulis D, Chappell LC, Gibbs RG, Williams D, Dave JR, Taylor P, de Swiet M, Poston L, Williamson C. Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre-eclampsia. BJOG 2005;112:299-305. 38. Chappell LC, Seed PT, Kelly FJ Briley A, Hunt BJ, Charnock-Jones DS, Mallet A, Poston L. Vitamin C and E supplementation in women at risk of pre-eclampsia is associated with changes in indices of oxidative stress and placental function. Am J Obstet Gynecol 2002;187:777-784. 39. Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L. A longitudinal study of biochemical variables in women at risk of pre-eclampsia. Am J Obs Gynecol 2002;187:127-36. 40. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, Parmar K, Bewley SJ, Shennan AH, Steer PJ, Poston L. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. 41. Chappell L, Poulton L, Halligan A, Shennan AH. Lack of consistency in research papers over the definition of pre-eclampsia. BJOG 1999;106:983-5.

Reviews

42. Oakeshott P, Chappell LC. Management of a new pregnancy in a woman with chronic hypertension. BMJ 2016 (in press). 43. Geenes V, Williamson C, Chappell LC. Obstetric cholestasis. The Obstetrician and Gynaecologist 2016 (in press). 44. Chappell LC, Milne F, Shennan AH. Uncertainties page: Is early induction or expectant management more beneficial in women with late preterm pre-eclampsia? BMJ. 2015 350: h191. doi: 10.1136/bmj.h191. 45. Nathan HL, Duhig K, Hezelgrave NL, Chappell LC, Shennan AH. Blood Pressure Measurement in Pregnancy. The Obstetrician and Gynaecologist 2015;17: 91–8. 46. Walker I, Chappell LC, Williamson C. Rational testing: Abnormal liver function tests in pregnancy. BMJ 2013; 347:f6055. doi: 10.1136/bmj.f6055. 47. Bramham K, Nelson-Piercy C, Brown MJ, Chappell LC. Postpartum management of hypertension. BMJ. 2013;346:f894. doi: 10.1136/bmj.f894.

48. Seshadri S, Oakeshott P, Nelson-Piercy C, Chappell LC. Prepregnancy care. BMJ 2012;344:e3467. 49. Duckworth S, Mistry H, Chappell LC. Vitamin supplementation in pregnancy. The Obstetrician and Gynaecologist 2012;14:175–178. 50. Griffin M, Chappell LC. Prediction of Pre-eclampsia – Screening, Biomarkers and Perspectives for the Future. European Obstetrics and Gynaecology 2012;7:18–24 51. Hezelgrave NL, Whitty CJ, Shennan AH, Chappell LC. Advising on travel during pregnancy. BMJ. 2011; 342:d2506.

3 of 5 52. Poston L, Chappell LC, Seed PT, Shennan AH. Biomarkers of oxidative stress in pre-eclampsia. Pregnancy Hypertension 2011 1; 22-27. 53. Abbott D, Atere-Roberts N, Williams A, Oteng-Ntim E. Chappell LC. Obstetric anal sphincter injury. BMJ 2010; 341:c3414. 54. Bramham K, Mistry HD, Poston L, Chappell LC, Thompson A. The Non-Invasive Biopsy - Will Urinary Proteomics make the Renal Tissue Biopsy Redundant? QJM 2009; 102(8):523-38. 55. Chappell LC. Recent advances in pre-eclampsia and eclampsia. Tropical Doctor 2004; 34:1. 56. Poston L, Chappell LC. Is oxidative stress involved in the aetiology of pre-eclampsia? Acta Paediatr Suppl 2001; 90:3-5. 57. Shennan AH, Chappell L. Pre-eclampsia. Contemp Clin Gynecol Obstet. 2001; 1:353-64. 58. Briley A, Chappell L, Kelly F, Shennan A, Poston L. The Vitamins in Pre-eclampsia Study. RCM Midwives Journal 2001; 4:288-91. 59. Chappell L, Shennan A. The role of uterine artery Doppler in obstetrics. CML Gynaecology and Obstetrics 1999; 5:57-61. 60. Chappell L, Bewley S. Pre-eclamptic toxaemia: the role of uterine artery Doppler. BJOG 1998; 105:379-82.

Editorials and commentaries

61. Chappell LC, Sandall J, Barnard AM, McManus RJ. Predicting pre-eclampsia. BMJ 2015; 351:h6349 doi: 10.1136/bmj.h6349. 62. Chappell LC, Bramham K, Shennan AH. Short-term prediction of preeclampsia: how close are we? Biomark Med. 2014; 8:455-8. doi: 10.2217/bmm.14.22. 63. Duhig KE, Chappell LC, Shennan AH. How placental growth factor detection might improve diagnosis and management of pre-eclampsia. Expert Rev Mol Diagn. 2014; 14:403-6. doi: 10.1586/14737159.2014.908121. 64. Chappell LC, Williamson C. Liver: Links between hepatobiliary diseases in and beyond pregnancy. Nat Rev Gastroenterol Hepatol. 2013 10(7):387-8. doi: 10.1038/nrgastro.2013.92. 65. Chappell LC, Calderwood C, Kenyon S, Draper ES, Knight M. Understanding patterns in maternity care in the NHS and getting it right. BMJ. 2013;346:f2812. doi: 10.1136/bmj.f2812. 66. Chappell LC. Commentary on ‘Preconception health care and congenital disorders: mathematical modelling of the impact of a preconception care programme on congenital disorders’ by Shannon G, Alberg C, Nacul L, Pashayan N. BJOG 2013. doi: 10.1111/1471-0528.12116. 67. Poston L, Chappell LC. How should women be advised on weight management in pregnancy? BMJ. 2012; 344:e2774. doi: 10.1136/bmj.e2774. 68. Chappell LC, Smith GC. Should pregnant women sleep on their left? BMJ. 2011; 342:d3659. 69. Chappell LC. Commentary: Complex medical conditions in pregnancy need appropriate multidisciplinary input. BMJ 2009; 339:b5179. 70. Chappell LC, Shennan AH. Assessment of proteinuria. BMJ 2008; 336:968-9. 71. Chappell LC, Germain S. Commentary: Controversies in management of diabetes from preconception to the postnatal period. BMJ 2008; 336:717-8.

RCOG Scientific Advisory Committee Paper

72. Chappell LC. Vitamin Supplementation in Pregnancy. RCOG 2009. http://www.rcog.org.uk/files/rcog- corp/SACPaper16VitaminSupplementation.pdf

Chapters

73. Chappell LC, Thangaratinam S, Myers JM. First-trimester identification of risk of pre-eclampsia, ed. Ledger W, Clark J. Recent Advances in Obstetrics and Gynaecology Vol. 26. JP Publishers 2015, pp 57-66.

4 of 5 74. Chappell LC. Antioxidants for pre-eclampsia. The Yearbook of Obstetrics and Gynaecology Volume 11. RCOG Press 2004, pp 76-92. 75. Chappell LC. Prophylaxis. ‘Pre-eclampsia’, ed. Critchley H, Maclean A, Poston L, Walker J., RCOG Press 2003, pp 276-89. 76. Ward JP, Chappell LC, Leach RM. Effects of BRL38227 and glibenclamide on small pulmonary arteries of the rat. ‘Resistance arteries, structure and function’, ed. Mulvany MJ et al., Elsevier Science Publishers 1991, pp139-43.

Editorial consultant to ‘Blooming Birth: how to get the pregnancy and birth you want’ by Lucy Atkins and Julia Guderian. Collins 2005

5 of 5