Table E-1. Mean (SEM) Diffuse and Neuritic Senile Plaque (SP) Plus Tangle (NFT) Counts

Table E-1. Mean (SEM) Diffuse and Neuritic Senile Plaque (SP) plus Tangle (NFT) counts for cognitively intact older adults by region using Khatchaturian Criteria.

Diffuse Plaques Neuritic

Plaques Measure/Region AD- Norm t-test AD- Norm t-test

Like al Like al (N= (N= (N= (N=

29) 30) 29) 30) Middle Frontal 45.28 10.51 4.56* 5.84 0.49 4.22*

Gyrus (6.34) (4.28) ** (1.27) (0.19) **

Middle Temporal 38.61 7.97 5.52* 5.28 0.51 4.07*

Gyrus (4.62) (3.07) ** (1.14) (0.28) **

Inferior Parietal 42.43 8.05 4.78* 6.93 1.21 4.18*

Lobule (6.71) (2.80) ** (1.30) (0.48) **

Occipital (Areas 31.32 6.27 5.64* 5.61 0.70 3.59*

18) (3.66) (2.56) ** (1.36) (0.27) ** CA-1 4.64 0.99 2.81* 1.35 0.25 2.48*

(1.16) (0.58) * (0.41) (0.16) * Amygdala 21.63 2.75 5.74* 8.46 0.49 3.68*

(3.33) (1.04) ** (2.32) (0.21) ** Entorhinal 10.41 3.66 3.40* 6.54 0.52 3.79*

(1.74) (0.99) ** (1.60) (0.25) **

NFT Counts: AD- Norm t-test

Like al Middle Frontal 0.80 0.13 1.71*

Gyrus (0.40) (0.05)

Middle Temporal 2.29 0.69 1.75*

Gyrus (0.88) (0.24)

Inferior Parietal 0.85 0.07 2.48*

Lobule (0.32) (0.04) *

Occipital (Areas 18 0.31 0.04 2.13* & 19) (0.12) (0.03)

CA-1 15.42 6.37 1.43ns

(5.66) (2.68) Amygdala 6.63 1.90 2.57*

(1.92) (0.42) * Entorhinal 9.13 4.54 2.53*

(1.48) (1.07) *

Note: *** p<.001, ** p<.01, * p<.05. SP per mm2 can be derived by dividing the means by 2.53. NFT per mm2 can be derived by multiplying the means by 1.76. Table E-2. Mean (SEM) Diffuse and Neuritic Senile Plaque (SP) plus Tangle (NFT) counts for cognitively intact older adults by region using CERAD Criteria.

Diffuse Plaques Neuritic

Plaques Measure/Region AD- Norm t-test AD- Norm t-test

Like al Like al (N= (N= (N= (N=

15) 44) 15) 44) Middle Frontal 42.93 22.37 2.09* 9.01 1.11 6.09*

Gyrus (7.91) (5.06) (2.06) (0.31) **

Middle Temporal 37.76 18.25 2.63* 8.39 0.98 6.42*

Gyrus (6.00) (3.85) * (1.73) (0.33) **

Inferior Parietal 34.84 21.58 1.38ns 11.12 1.60 7.44*

Lobule (6.39) (5.16) (1.82) (0.43) **

Occipital (Areas 28.61 15.16 2.20* 10.01 0.76 7.48*

18) (4.16) (3.26) (2.00) (0.21) ** CA-1 5.69 1.77 2.70* 2.10 0.33 3.78*

(1.77) (0.62) * (0.71) (0.13) ** Amygdala 22.61 7.81 3.39* 12.27 1.50 4.54*

(4.45) (2.04) ** (3.57) (0.71) **

Entorhinal 11.87 5.31 2.80* 9.45 1.44 4.60*

(2.45) (1.09) * (2.76) (0.42) **

NFT Counts: AD- Norm t-test

Like al Middle Frontal 1.33 0.16 2.65*

Gyrus (0.74) (0.07) *

Middle Temporal 3.53 0.78 2.74*

Gyrus (1.63) (0.19) *

Inferior Parietal 1.43 0.12 3.85*

Lobule (0.58) (0.04) **

Occipital (Areas 18 0.45 0.08 2.63* & 19) (0.21) (0.04) *

CA-1 16.19 9.03 1.00ns

(3.95) (4.12) Amygdala 9.85 2.18 3.86*

(3.28) (0.40) ** Entorhinal 9.64 5.83 1.78*

(2.38) (0.96)

Note: *** p<.001, ** p<.01, * p<.05. SP per mm2 can be derived by dividing the means by 2.53. NFT per mm2 can be derived by multiplying the means by 1.76. Table E-3. Mean (sd) mental status scores by neuropathological criteria**.

Neuropathological Diagnostic Criteria:

Khatchaturian CERAD NIA-

Reagan MEASUR All AD- Norm AD- Norm AD- Norm NIA

E Case Like al Like al Like al -RI s ** ** t-

test AGE (@ 82.99 84.1 81.92 85.7 82.04 85.2 82.68 ns

test) (7.31) 4 (7.44) 3 (7.26) 2 (7.28)

(7.1 (6.9 (7.6

2) 8) 9) Education 16.34 15.9 16.73 16.2 16.39 16.4 16.33 ns

(2.58) 3 (2.32) 0 (2.65) 3 (2.60)

(2.8 (2.4 (2.7

1) 6) 0) Brain 1227. 1209 1245 1210 1234 1231 1227 ns

Weight 8 (82) (109) (104 (96) (102 (98) (97.7) ) ) Language Animal 15.12 14.1 16.07 13.2 15.40 13.0 15.14 ns

Naming (4.27) 1 (4.67) 9 (4.72) 0 (4.48)

(3.6 (2.5 (2.8

1) 9) 3) COWA 35.24 35.1 35.31 38.6 34.16 42.6 34.42 ns

(10.4 7 (11.5 7 (10.9 0 (10.5

8) (9.4 1) (8.4 3) (6.2 8)

9) 2) 3) BNT 14.13 14.3 13.89 14.5 14.00 14.3 14.10 ns

(short) (2.12) 8 (2.86) 8 (2.38) 3 (2.24)

(max 15) (0.7 (0.5 (0.5

5) 1) 2) Memory

List 18.56 18.7 18.41 18.7 18.50 16.8 18.78 ns

Learning (4.55) 3 (4.95) 7 (4.60) 3 (4.49)

(max 30) (4.1 (4.5 (5.1

5) 5) 2) Delayed 5.76 5.62 5.90 5.31 5.90 4.00 5.98 2.0 Recall (2.33) (2.0 (2.57) (2.1 (2.40) (2.3 (2.26) 2*

(max 10) 8) 4) 7)

Savings 77.6 77.7 77.4 75.8 78.1 60.8 79.6 ns

% % % % % % %

(25.3) (26. (24.7) (29. (24.3) (35. (23.5)

6) 4) 2) WMS 26.38 26.2 26.50 24.2 27.05 20.8 27.0 2.8

Logical (7.56) 5 (9.26) 5 (8.16) 0 (7.62) 2*

(5.3 (4.9 (4.2

5) 4) 1) Other

Trailmakin 58.05 54.5 61.55 54.6 58.91 55.0 58.35 ns

g A (38.9 5 (46.7 7 (42.3 0 (40.3

5) (29. 2) (22. 3) (23. 7)

97) 87) 45) Temporal 0.89 1.07 0.71 1.43 0.71 2.14 0.71 ns

Orientation (2.53) (3.2 (1.61) (3.9 (1.88) (5.6 (1.76)

(errors) 3) 6) 7) Wechsler 6.72 6.58 6.85 7.00 6.63 7.00 6.69 ns

Mental (1.50) (1.3 (1.61) (1.4 (1.53) (1.5 (1.50)

Control 9) 1) 8)

** Note: All t-tests for comparisons between Khatchaturian and

CERAD groups are nonsignificant; *p<.05.