<p>Table E-1. Mean (SEM) Diffuse and Neuritic Senile Plaque (SP) plus Tangle (NFT) counts for cognitively intact older adults by region using Khatchaturian Criteria.</p><p>Diffuse Plaques Neuritic </p><p>Plaques Measure/Region AD- Norm t-test AD- Norm t-test</p><p>Like al Like al (N= (N= (N= (N=</p><p>29) 30) 29) 30) Middle Frontal 45.28 10.51 4.56* 5.84 0.49 4.22*</p><p>Gyrus (6.34) (4.28) ** (1.27) (0.19) **</p><p>Middle Temporal 38.61 7.97 5.52* 5.28 0.51 4.07*</p><p>Gyrus (4.62) (3.07) ** (1.14) (0.28) **</p><p>Inferior Parietal 42.43 8.05 4.78* 6.93 1.21 4.18*</p><p>Lobule (6.71) (2.80) ** (1.30) (0.48) **</p><p>Occipital (Areas 31.32 6.27 5.64* 5.61 0.70 3.59*</p><p>18) (3.66) (2.56) ** (1.36) (0.27) ** CA-1 4.64 0.99 2.81* 1.35 0.25 2.48*</p><p>(1.16) (0.58) * (0.41) (0.16) * Amygdala 21.63 2.75 5.74* 8.46 0.49 3.68*</p><p>(3.33) (1.04) ** (2.32) (0.21) ** Entorhinal 10.41 3.66 3.40* 6.54 0.52 3.79*</p><p>(1.74) (0.99) ** (1.60) (0.25) **</p><p>NFT Counts: AD- Norm t-test</p><p>Like al Middle Frontal 0.80 0.13 1.71*</p><p>Gyrus (0.40) (0.05)</p><p>Middle Temporal 2.29 0.69 1.75*</p><p>Gyrus (0.88) (0.24)</p><p>Inferior Parietal 0.85 0.07 2.48*</p><p>Lobule (0.32) (0.04) *</p><p>Occipital (Areas 18 0.31 0.04 2.13* & 19) (0.12) (0.03)</p><p>CA-1 15.42 6.37 1.43ns</p><p>(5.66) (2.68) Amygdala 6.63 1.90 2.57*</p><p>(1.92) (0.42) * Entorhinal 9.13 4.54 2.53*</p><p>(1.48) (1.07) *</p><p>Note: *** p<.001, ** p<.01, * p<.05. SP per mm2 can be derived by dividing the means by 2.53. NFT per mm2 can be derived by multiplying the means by 1.76. Table E-2. Mean (SEM) Diffuse and Neuritic Senile Plaque (SP) plus Tangle (NFT) counts for cognitively intact older adults by region using CERAD Criteria.</p><p>Diffuse Plaques Neuritic </p><p>Plaques Measure/Region AD- Norm t-test AD- Norm t-test</p><p>Like al Like al (N= (N= (N= (N=</p><p>15) 44) 15) 44) Middle Frontal 42.93 22.37 2.09* 9.01 1.11 6.09*</p><p>Gyrus (7.91) (5.06) (2.06) (0.31) **</p><p>Middle Temporal 37.76 18.25 2.63* 8.39 0.98 6.42*</p><p>Gyrus (6.00) (3.85) * (1.73) (0.33) **</p><p>Inferior Parietal 34.84 21.58 1.38ns 11.12 1.60 7.44*</p><p>Lobule (6.39) (5.16) (1.82) (0.43) **</p><p>Occipital (Areas 28.61 15.16 2.20* 10.01 0.76 7.48*</p><p>18) (4.16) (3.26) (2.00) (0.21) ** CA-1 5.69 1.77 2.70* 2.10 0.33 3.78*</p><p>(1.77) (0.62) * (0.71) (0.13) ** Amygdala 22.61 7.81 3.39* 12.27 1.50 4.54*</p><p>(4.45) (2.04) ** (3.57) (0.71) **</p><p>Entorhinal 11.87 5.31 2.80* 9.45 1.44 4.60*</p><p>(2.45) (1.09) * (2.76) (0.42) **</p><p>NFT Counts: AD- Norm t-test</p><p>Like al Middle Frontal 1.33 0.16 2.65*</p><p>Gyrus (0.74) (0.07) *</p><p>Middle Temporal 3.53 0.78 2.74*</p><p>Gyrus (1.63) (0.19) *</p><p>Inferior Parietal 1.43 0.12 3.85*</p><p>Lobule (0.58) (0.04) **</p><p>Occipital (Areas 18 0.45 0.08 2.63* & 19) (0.21) (0.04) *</p><p>CA-1 16.19 9.03 1.00ns</p><p>(3.95) (4.12) Amygdala 9.85 2.18 3.86*</p><p>(3.28) (0.40) ** Entorhinal 9.64 5.83 1.78*</p><p>(2.38) (0.96)</p><p>Note: *** p<.001, ** p<.01, * p<.05. SP per mm2 can be derived by dividing the means by 2.53. NFT per mm2 can be derived by multiplying the means by 1.76. Table E-3. Mean (sd) mental status scores by neuropathological criteria**.</p><p>Neuropathological Diagnostic Criteria:</p><p>Khatchaturian CERAD NIA-</p><p>Reagan MEASUR All AD- Norm AD- Norm AD- Norm NIA</p><p>E Case Like al Like al Like al -RI s ** ** t-</p><p> test AGE (@ 82.99 84.1 81.92 85.7 82.04 85.2 82.68 ns</p><p> test) (7.31) 4 (7.44) 3 (7.26) 2 (7.28)</p><p>(7.1 (6.9 (7.6</p><p>2) 8) 9) Education 16.34 15.9 16.73 16.2 16.39 16.4 16.33 ns</p><p>(2.58) 3 (2.32) 0 (2.65) 3 (2.60)</p><p>(2.8 (2.4 (2.7</p><p>1) 6) 0) Brain 1227. 1209 1245 1210 1234 1231 1227 ns</p><p>Weight 8 (82) (109) (104 (96) (102 (98) (97.7) ) ) Language Animal 15.12 14.1 16.07 13.2 15.40 13.0 15.14 ns</p><p>Naming (4.27) 1 (4.67) 9 (4.72) 0 (4.48)</p><p>(3.6 (2.5 (2.8</p><p>1) 9) 3) COWA 35.24 35.1 35.31 38.6 34.16 42.6 34.42 ns</p><p>(10.4 7 (11.5 7 (10.9 0 (10.5</p><p>8) (9.4 1) (8.4 3) (6.2 8)</p><p>9) 2) 3) BNT 14.13 14.3 13.89 14.5 14.00 14.3 14.10 ns</p><p>(short) (2.12) 8 (2.86) 8 (2.38) 3 (2.24)</p><p>(max 15) (0.7 (0.5 (0.5</p><p>5) 1) 2) Memory</p><p>List 18.56 18.7 18.41 18.7 18.50 16.8 18.78 ns</p><p>Learning (4.55) 3 (4.95) 7 (4.60) 3 (4.49)</p><p>(max 30) (4.1 (4.5 (5.1</p><p>5) 5) 2) Delayed 5.76 5.62 5.90 5.31 5.90 4.00 5.98 2.0 Recall (2.33) (2.0 (2.57) (2.1 (2.40) (2.3 (2.26) 2*</p><p>(max 10) 8) 4) 7)</p><p>Savings 77.6 77.7 77.4 75.8 78.1 60.8 79.6 ns</p><p>% % % % % % %</p><p>(25.3) (26. (24.7) (29. (24.3) (35. (23.5)</p><p>6) 4) 2) WMS 26.38 26.2 26.50 24.2 27.05 20.8 27.0 2.8</p><p>Logical (7.56) 5 (9.26) 5 (8.16) 0 (7.62) 2*</p><p>(5.3 (4.9 (4.2</p><p>5) 4) 1) Other</p><p>Trailmakin 58.05 54.5 61.55 54.6 58.91 55.0 58.35 ns</p><p> g A (38.9 5 (46.7 7 (42.3 0 (40.3</p><p>5) (29. 2) (22. 3) (23. 7)</p><p>97) 87) 45) Temporal 0.89 1.07 0.71 1.43 0.71 2.14 0.71 ns</p><p>Orientation (2.53) (3.2 (1.61) (3.9 (1.88) (5.6 (1.76)</p><p>(errors) 3) 6) 7) Wechsler 6.72 6.58 6.85 7.00 6.63 7.00 6.69 ns</p><p>Mental (1.50) (1.3 (1.61) (1.4 (1.53) (1.5 (1.50)</p><p>Control 9) 1) 8)</p><p>** Note: All t-tests for comparisons between Khatchaturian and </p><p>CERAD groups are nonsignificant; *p<.05.</p>