General, Organic and Biological Chemistry

CHEMISTRY 109-3M GENERAL, ORGANIC AND BIOLOGICAL CHEMISTRY Fall 2016 Instructor: Uttam Pokharel, Ph. D. Office: BEA 137 Phone: (985)448-4504 Email: [email protected] Course Meeting: 12:00 -1:20 pm (TR) Room: BEA 165 Office Hours: MW: 11:00 – 12:00 noon T: 10:00 – 12:00 noon TR: 1:00 – 4:00 pm Whenever I am in the office you are welcome to come in and ask questions. COURSE DESCRIPTION: CHEM 109. General, Organic, and Biological Chemistry for Nursing. 3-3-0. Prerequisite: Non-developmental Math placement. Emphasis is on broad aspects of general, organic, and biochemistry necessary for the comprehension of biological processes occurring within the human body. (40.0599) PRE-/CO-REQUISITE: Non-developmental math placement

REQUIRED TEXT: General, Organic, and Biochemistry, 3nd edition by Frost, Deal, & Timberlake (ISBN: 978-0134042428) plus Mastering Chemistry access code

GENERAL EDUCATION STUDENT LEARNING OUTCOMES: CHEM 109, as a course specially designed for nursing students, fulfills three hours of general education requirements in the area of the natural sciences and is this designed to enable students to meet the following broad outcome for all natural sciences: Goal: Upon completion of the undergraduate curriculum, students will be able to comprehend and to apply the basic principles of science and methods of scientific inquiry. Students will be able to 1. Differentiate among facts, laws, theories, and hypotheses 2. Define major concepts, principles, and fundamental theories in at least one area of science 3. Demonstrate an understanding of the basic terminology in at least one area of science 4. Formulate a hypothesis, given a simple problem or questions, and design a valid experiment to test it 5. Make informed decisions on contemporary consumer or social issues demanding scientific literacy

For further explanation of the learning objectives associated with this goal, go to HtmlResAnchor http://www.nicholls.edu/gened/goals_objectives.html. STUDENT OUTCOME OBJECTIVES: This one semester course is designed to introduce students to the general principles of chemistry geared to the allied health major including organic chemistry and biochemistry. The principles fall into the four main areas of: 1. Measurement and Mathematical Concepts (MMC) 2. Molecular Structures (MS) 3. Solution and Acid/Base Chemistry (ABC) 4. Biochemistry (BC) Upon successful completion of this course, the student should be able to:  Classify different forms of matter. Distinguish physical and chemical properties. Identify and describe the properties of metals and nonmetals (MS).  Measuring items and applying rules for significant figures correctly (MMC).  Convert English to metric units of measurement, and vice-versa. Perform simple dosage calculations through unit conversions (MMC).  Explain the basic relationships of gas pressure, temperature, volume, and amount. Apply Boyle’s Law and Charles’ Law (MMC).  Identify the number of subatomic particles present in atoms and ions. Distinguish between isotopes and ions by the number of subatomic particles present. Distinguish Mass Number from Atomic Mass (MS).  Identify specific charges on ions. Distinguish and name ionic and binary covalent compounds. Identify the number of valence electrons in the main group elements (MS).  Determine the molecular shapes of carbon, nitrogen, and oxygen in a covalent compound. Determine the polarity of the covalent bond and a covalent compound (MS).  Distinguish representatives of organic compounds (including Lewis, condensed, skeletal, 3-D ball, and stick structures). Define structural isomer (MS).  Recognize organic families and hydrocarbon functional groups (MS).  Distinguish isomers of organic compounds as structural, cis/trans, enatiomers, and diastereomers. Identify chiral centers in organic molecules (MS).  Identify a carbohydrate by its molecular formula and functional groups. Distinguish the simple sugars by structure and function (BC).  Determine the ring structure of a linear monosaccharide. Recognize and name a glycosidic linkage. Identify the products of the following reactions for carbohydrates: condensation, hydrolysis, oxidation and reduction. Describe what is a reducing sugar (BC).  Describe the structure and function of complex carbohydrates, and identify the corresponding glycosidic linkages (BC).  Draw fatty acid salts in water, a “micelle”. Describe the difference between a saturated versus an unsaturated fatty acid. Draw a triglyceride, and identify its functional groups. Distinguish between a fat and an oil.  Distinguish the structural differences between a triglyceride and a phospholipid. Identify the function of phospholipids. Draw a phospholipid bilayer (BC).  Determine the direction of the flow of water across a membrane in osmosis and diffusion (ABC). Distinguish the three main mechanisms of transport across a biological membrane (BC).  Distinguish between a solution and a suspension. Distinguish solutions as electrolyte, non-electrolyte, or weak electrolyte (ABC).  Calculate the concentration of a solution. Describe how you would make an aqueous solution of a known concentration using a solid solute or concentrated stock solution (ABC).  Identify and learn how to name the strong acids and bases. Identify an acid, base, conjugate acid and conjugate base. Write conjugate acid-base reactions. Write a balanced neutralization reaction (ABC).  Predict the strength of a weak acid from its Ka, or the pKa. Determine the acidity of a solution from the pH scale. Calculate the pH of a solution from its hydronium ion concentration and vice-versa (ABC).  Explain how buffering works, and the components that make up a buffer. Apply LeChatelier’s principle to the bicarbonate buffer system (ABC).  Determine the predominant species present in aqueous solution for the functional groups amine and carboxylic acid, found in amino acids, at a given pH (BC).  Draw the general structure of an amino acid in zwitterion form. Identify the functional groups: amide, thiol, aromatic, and disulfide. Classify the amino acids by R- group polarity and charge (BC).  Describe the levels of structure and various functions of proteins (BC).  Establish whether a chemical reaction is exothermic or endothermic, by using a reaction free energy diagram. Apply the factors that affect enzyme activity to a given situation. Distinguish between competitive and noncompetitive types of inhibition (BC).  Identify parts of a nucleotide and a nucleic acid. Distinguish purines and pyrimidines. Identify the structure and function of the nucleic acids DNA and RNA. Provide the complementary strand for a given strand of DNA showing the 5’ and 3’ ends (BC).

ASSESSMENT STATEMENT: Nicholls State University is committed to continuous improvement of student learning. To achieve this goal, the University has adopted a web-based assessment and e-Portfolio system called LiveText. With LiveText, students will have the ability to tract their own growth and organize their college coursework while at the same time helping the university provide the best education possible, now and in the future. Students will enjoy (1) space in the LiveText cloud to upload and store documents, presentations, and other files, (2) a single electronic place to organize and download projects from all courses for preparation of portfolios and other presentations to future employers and graduate school admissions, and (3) access to their personal assessment data as generated by the University. [Use of LiveText is a University requirement, and you will be required to upload assignments from this class as specified by the instructor. Therefore, unless you already have an account to use LiveText, you must purchase a license for LiveText for this class. Licenses for LiveText are paid through the University as an “Electronic Assessment License” and will be charged only once to each student. If you don’t already have an account, you will receive a “Key Code” through email at the beginning of this course that will permit you to establish one. You may use your LiveText account for up to five years. If you do not yet have a license to use LiveText, please contact [email protected] within one week of the beginning of this course.]

HOMEWORK: Homework will be given for each chapter on Mastering Chemistry. There will be total 10 assignments throughout the course. The due date will be two days after finishing the chapter. The homework will be available before the beginning of a chapter. Clickers: Clicker questions will be asked to check your understanding of course materials while lecturing and increase your participation in the classroom activities. Each questions is of two points: one point for participation and one point for correct response. Clicker point cannot be made-up even if your excuse is valid. To do well in this questions, read your chapter before coming to the class. EXAMS: 4 exams and 1 comprehensive Final exam will be given. I will drop your lowest exam grade (not including the Final). All students must take the Final. A tentative schedule for exams is listed at the end of this syllabus. These dates may change (with the exception of the final). I will announce all exams dates in class as well as post them on moodle.

REVIEW SESSIONS: Review sessions may be given periodically to discuss problems and assignments. The time for these sessions will be announced.

GRADING: The grading will be as follows. Item % Weight Homework 20% Clickers 10% Exams 45% Final Exam 25% Total 100%

METHOD OF EVALUATION: The grades earned will be as follows 90%-100% A 80%-89.99% B 70%-79.99% C 60%-69.99% D 59.99% and under F

MAKE-UP POLICY: Make-up exams will be given for excused absences only. Homework assignments will not be accepted late. ATTENDANCE POLICY: Attendance is mandatory. If you remain absent, you will lose clicker points of the day.

ACADEMIC HONESTY POLICY: Any student found cheating will be subject to the penalties as stated in the Student Code of Conduct handbook; including but not limited to a score of zero on exam, expulsion from the class or expulsion from the University.

SEMESTER WITHDRAWL: The last day to withdraw from the class with a “W” is October 28th.

ACADEMIC DISABILITIES POLICY: If you have a documented disability that requires assistance, you will need to register with the Office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

CLASS DISRUPCTION: Are not tolerated. The use of cell phones, pager and/or any other electronic personal devise in class is prohibited. Any infractions may result in the dismissal from class.

ACADEMIC GRIEVANCES: The proper procedure for filing grade appeals or grievances related to academic matters is listed in Section 5 of the Code of Student Conduct and at the following link: http://www.nicholls.edu/documents/student_life/code_of_conduct.pdf. ASSISTANCE WITH STUDYING AND ASSIGMENTS The Tutoring Center at 143 Peltier Hall. Call 985-448-4100, email: [email protected], or visit http://www.nicholls.edu/academic-enhancement/ The Writing Center at 144 Peltier Hall. Call 985-448-4100, email: [email protected], or visit http://www.nicholls.edu/academic-enhancement/ Online Tutoring through Moodle. Look for the Brainfuse log-in link on the home page,http://moodle2.nicholls.edu/moodle/

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for:  Reading regular emergency notifications on the NSU website;  Knowing how to use and access moodle;  Being familiar with emergency guidelines;  Evacuating textbooks and other course materials;  Knowing their moodle student login and password;  Contacting faculty regarding their intentions for completing the course.

Faculty are responsible for:  The development in the use of the moodle software;  Having a plan for continuing their courses using only moodle and email;  Continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses;  Making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like only in the immediate semester following the emergency. HOW TO SUCCEED IN CHEMISTRY CLASS 1. Pre-read the reading assignment before class. Even if you only skim through the material you will benefit. Study key concepts, define key words and equations. These can be found at the end of each chapter. 2. Go to Class. Be prepared with questions to ask! 3. Before the next class, review the previous lecture. Take note of any questions or difficulties that you might have with the material covered. 4. If you have questions, make sure that they are answered before the next lecture. Come by and discuss these with me or with someone else. 5. Do all of the assignments before the due date! Print out the questions and work the out on paper before entering the answer on-line. 6. You should expect to spend at least six or more hours outside of class for this course. Plan your schedule accordingly!

Tentative Schedule: Date Topic Aug. 22, 24, Chapter 1. Chemistry basics – matter and measurement 26, 29 Aug 31, Sept Chapter 2. Atoms and radioactivity 2, 7 Sept 9, 12, Chapter 3. Compounds – putting particles together 12, 16 Sept 19 Exam 1 (Chapters 1 – 3) Sept 21, 23, Chapter 4. Introduction to organic chemistry 26, 28 Oct 3, 5, 7 Chapter 5. Chemical reactions Oct 10, 12, Chapter 6. Carbohydrates – Life’s sweet molecules 14 Oct 17 Exam 2 (Chapters 4 – 6) Oct 19, 21, Chapter 7. What’s the attraction? State changes, solubility, and lipids 26 Oct 28, 31, Chapter 8. Solution chemistry – how sweet is your tea? Nov 2 Nov 4, 7, 9 Chapter 9. Acid, bases, and buffers in the body Nov 11 Exam 3 (Chapters 7-9) Nov 14, 16, Chapter 10. Proteins – Workers of the cell 18 Nov 28, 30, Chapter 11. Nucleic acids – Big molecules with a big role Dec 2 Dec 5 Exam 4 (Chapter 10 and 11) Dec 9 Final Exam (1:00 – 3:00 PM), Cumulative

Holidays: Aug 5. Labor day holiday Sept 30. Fall break #1 Oct 24. Fall break #2 Nov 21. Thanksgiving holiday Nov 23. Thanksgiving holiday Nov 25. Thanksgiving holiday

Note: This is not a binding contract. This syllabus is subject to change throughout the course.