The Mentor Is Not Required to Be Employed in the Applicant S Institution

Appendix A: RO3 Mentoring Plan

Nature of mentoring : Dr. INVESTAGATOR will have a primary and secondary mentor for this project. Dr. PRIMARY MENTOR will serve as Dr. INVESTAGOR’s primary mentor--‘primary’ being the one with whom Dr. INVESTAGATOR has the greatest amount of mentoring interaction. His time is reflected through an FTE percentage. SECONDARY MENTOR, MD will serve as the secondary mentor, with time reflected through specific consultation. Dr. PRIMARY MENTOR’s distinguished career has focused innovative tobacco prevention and cessation programs for high-risk teens. During the 30 years of his research career, Dr. PRIMARY MENTOR has conducted multiple epidemiologic and intervention studies aimed at studying tobacco use among young populations (grade students, college students, ethnic minority youth, etc.). Pertinent to this proposal, he has extensive experience modeling and testing theory with data such as those in Dr. INVESTAGATOR’s proposed study. He also served as a key investigator in seminal studies of two of the primary instruments used in the proposed study (the mFTQ and Stages of Change). Dr. PRIMARY MENTOR was one of the first investigators to address nicotine dependence among adolescents as being a major barrier to quitting and one that needs to be adequately measured. His creative approaches to tobacco control using behavioral theories and computer technologies have led to successful smoking prevention and cessation programs some of which are being disseminated nationwide and abroad SECONDARY MENTOR, MD, who will serve as Dr. INVESTAGATOR’s co-mentor, has worked in the field of tobacco control for 28 years, publishing over 100 relevant articles. Dr. SECONDARY MENTOR developed and validated the Hooked On Nicotine Checklist (HONC), a reliable and valid measure of youths’ diminished autonomy over tobacco. The HONC has significantly enhanced the field’s knowledge of youth tobacco addiction, particularly related to the rapid onset of youth dependence. Although Dr. INVESTAGATOR is an established expert in the field of teen smoking cessation, most of her funded research has been in intervention development and trials. Dr. INVESTAGATOR has not received funding as a PI for the type of research proposed herein. Building on existing collaborations with Drs. PRIMARY MENTOR and SECONDARY MENTOR, the overriding purpose of mentoring is to foster Dr. INVESTAGATOR’s professional advancement toward theory and model building using the data she and colleagues have acquired from N-O-T trials over the past decade, and to establish her NIH career along this line of research inquiry (See Letters of Commitment).

Expected outcomes: Three types of outcomes are expected: knowledge, application, and career enhancement. First, the general expected knowledge outcomes for Dr. INVESTAGATOR are increased understanding and application of theoretical integration and model building related to nicotine dependence. Second, the applied outcomes are enhanced utilization of the N-O-T Master Data Base using methods similar to those in this RO3, and subsequent R21s or RO1s resulting from this RO3, particularly around emerging new research questions and hypotheses. If funded, not only will this project establish Dr. INVESTAGATOR as a first-time NIH investigator, she will increase the likelihood of productive outcomes resulting from the study through expert guidance of the mentors. Third, it is important to underscore how the mentoring provided through this project will further Dr. INVESTAGATOR’s career outcomes and provide her with assets she might not otherwise receive. Specifically, mentoring will provide on-going intensive guidance and constructive feedback to Dr. INVESTAGATOR on documents and/or processes associated with the project, particularly through planned interactions shown in Table 1. Because UNIVERSITYA had few NIH funded investigators and only one other expert in teen tobacco research during the formative years of Dr. INVESTAGATOR’s career, intensive mentoring was not available. In fact, Dr. INVESTAGATOR never had a formal mentor. Mentoring by Dr. PRIMARY MENTOR will fill an unmet need as Dr. INVESTAGATOR moves into the next phase of her career, ideally transitioning into an NIH funded scientist. It is expected that the mentoring relationship will enhance opportunities to network with scholars who are leaders in our field. Specifically, the relationship is expected to enhance (a) invitations to serve on relevant national committees; (b) NIH study section participation; (c) participation on multi-institutional research teams, projects, or grant submissions by Drs. SECONDARY MENTOR or PRIMARY MENTOR; and (d) multi-investigator publications. 1

2 Frequency/Method of mentoring : Methods of communication will include (1) teleconference, (2) email, and (3) in-person meetings at MD UNIVERSITYB, UNIVERSITYA, and national scientific meetings. The frequency and duration of each type of communication and contact are specified below in Table 1 .

1. Teleconference. These calls will occur monthly on the third Thursday of each month with a duration of approximately 1 hour (12 pm central time/2 pm eastern time), except months where in-person meetings take place. Whenever feasible, Drs. INVESTAGATOR and PRIMARY MENTOR will use Skype™ video features to enhance our telephone communication. Agreed upon topics are shown in Table 1. Dr. SECONDARY MENTOR will be invited to participate as needed based on his expertise (e.g., Meeting 5, 14).

2. Email correspondence. We will use email correspondence as a supplemental and necessary form of communication in between teleconferences and in-person meetings.

3. In-person meetings. Drs. INVESTAGATOR and PRIMARY MENTOR will meet in-person five times over the course of two years. Two visits will occur during the annual Society for Research on Nicotine and Tobacco (SRNT), of which both INVESTAGATOR and PRIMARY MENTOR are members. We will arrange time together that accommodates our mutual travel schedules. Two visits will occur at MD UNIVERSITYB in CITY, STATE, and one visit will occur at UNIVERSITYA in CITY, STATE. These university visits will be arranged in advance per our mutual schedules and will occur over a 2-day period. Refer to Table 1 for details.

Table 1: Monthly topics over 24-month period

3 M 4 Topic 5 Type of Contact o n t h

6 1 7 Study overview and organization (“getting started”) 8 Teleconference/Skype

( N o v . )

9 2 10 Primary research questions and hypotheses 11 Teleconference/Skype

12 3 13 Overview of N-O-T program and historical data base 14 Teleconference/Skype review

15 4 Anticipated study challenges/solutions; professional In-person contact networking; introductions to Dr. PRIMARY MENTOR’s (@ 2011 SRNT 17TH other colleagues and collaborators attending the meeting ANNUAL MEETING) 16 5 17 Applied theoretical models relevant to teen tobacco 18 Teleconference/Skype addiction

19 6 20 Current literature on adolescent nicotine dependence 21 Teleconference/Skype

22 7 23 Revisit project Aims, hypothesis, and analytic plans 24 Teleconference/Skype (including regression modeling)

25 8 26 Introductions to Dr. PRIMARY MENTOR’s colleagues; 27 In person contact discussions of new projects and collaborations with MD UNIVERSITYB; meeting with Dr. SUPPORT PERSON 28 (@ MD UNIVERSITYB) (see appended Letter of Support); Dr. INVESTAGATOR will give seminar the project; discussion of career goals

29 9 30 Data validation processes/reliability 31 Teleconference/Skype

32 1 33 Potential conference abstract submissions 34 Teleconference/Skype 0

35 1 36 Missing data and imputation methods 37 Teleconference/Skype 1

38 1 39 Introductions to Dr. INVESTAGATOR’s colleagues; 40 In-person contact 2 continued discussions of new projects/collaborations with INVESTIGATOR’s team and MD UNIVERSITYB; 41 (@ UNIVERSITYA) Drs. INVESTIGATOR and PRIMARY MENTOR will give joint seminar on the project.

42 1 43 Missing data and imputation methods 44 Teleconference/Skype 3

( N o v . )

45 1 46 Moderation and mediation path models 47 Teleconference/Skype 4

48 1 49 Preliminary discussion of manuscript/abstract proposals 50 Teleconference/Skype 5

51 1 52 Networking; introductions to Dr. PRIMARY MENTOR’s 53 In-person contact 6 other colleagues and collaborators attending the meeting; joint presentation 54 (@ 2012 SRNT 17TH ANNUAL MEETING)

55 1 56 Prediction model development 57 Teleconference/Skype 7 58 1 59 Data interpretation/results 60 Teleconference/Skype 8

61 1 62 Data interpretation/results 63 Teleconference/Skype 9

64 2 65 Manuscript discussion/abstract submission of final 66 Teleconference/Skype 0 results

67 2 68 Subsequent NIH application submissions 69 Teleconference/Skype 1

70 2 71 Subsequent NIH application submissions 72 Teleconference/Skype 2

73 2 74 “Wrap Up” and finalizing grant submission for October 75 In-person contact 3 2012; discussion of career goals 76 (@ MD UNIVERSITYB)

77 2 78 -- 79 -- 4

Evidence of the mentor’s commitment to mentoring : Dr. PRIMARY MENTOR is known for his generous spirit. Despite an active research portfolio, he continues to train and advise students, medical professionals, and other researchers on tobacco-related topics and issues. He directs the Tobacco Outreach Education Program, which is supported by funds from the Comprehensive Tobacco Settlement Agreement and appropriated by the Texas Legislature to MD UNIVERSITYB, to enhance provider skills and knowledge. Dr. PRIMARY MENTOR is Director of the newly established eHealth Technology Core at M. D. UNIVERSITYB, so he provides his abundant expertise related to computer technology in cancer prevention to junior investigators. He also was recently (2009) nominated for the Robert M. Chamberlain Distinguished Mentor Award which recognizes and honors faculty members whose careers have underscored the value of mentoring at The University of Texas M D UNIVERSITYB Cancer Center. Dr. SECONDARY MENTOR has a long-time commitment to mentoring tobacco researchers. He was on the steering committee that developed and piloted a collaborative, doctoral-level, tobacco-control research training program, “Training the Next Generation of Tobacco-Control Researchers” (1999–2001). This was a joint initiative between the Harvard School of Public Health, the University of Massachusetts Boston and the Massachusetts Department of Health funded by the Robert Wood Johnson Foundation.

Mentors’ proposed percent effort : Dr. PRIMARY MENTOR will contribute 2.0% effort each year as Co-I. Dr. SECONDARY MENTOR will serve as a paid consultant, estimated up to 24 hours per year.

Assessment of success of this mentoring plan: Dr. INVESTIGATOR’s progress will be tracked through successful submission of a subsequent R21 or R01 application on adolescent nicotine dependence within 12 months of the conclusion of the R03 award. This outcome will serve as benchmark toward her career goals of increased NIH funding. At least four resulting team manuscripts (no later than 12 months of the conclusion of the award) relevant to the proposed work will serve as an indicator of her goal to provide new scientific contributions to the field of teen smoking cessation.