As Recommended by the Queensland Health Medicines Advisory Committee (QHMAC)

MARCH 2013 Summary of Changes to the Queensland Health List of Approved Medicines (LAM) as recommended by the Queensland Health Medicines Advisory Committee (QHMAC)

ITEM MEDICINE COMMITTEE DATE EFFECTIVE RESTRICTION NUMBER DECISION

13/018 ALCOHOL (ETHANOL) ADDED 30-Apr-13 INJECTION 100%, 5mL 13/011 ALPROSTADIL Injection ADDED 30-Apr-13 Neonatal and Paediatric 500 microgram per mL Staff Specialists to use to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon a patent ductus for survival. 13/018A2 Digoxin immune Fab ADDED 30-Apr-13 Specialist Staff and (Ovine) Powder for Country Medical injection 40mg Superintendents for the (DigiFab®) treatment of cardiac glycoside intoxication resulting in life- threatening cardiac arrhythmias; cardiac arrest; cardiac decompensation with hypotension; serum potassium >5.5mmol/L. In the absence of these recognised indications of cardiac glycoside toxicity, use may be based solely on serum digoxin ITEM MEDICINE COMMITTEE DATE EFFECTIVE RESTRICTION NUMBER DECISION

concentration in either chronic toxicity (if >8 micrograms/L ) or in acute overdose (if >16 micrograms/L).

13/012 ICATIBANT Injection, ADDED 30-Apr-13 Immunology physicians or single use pre-filled Emergency Department syringe 30mg in 3mL physicians, after consultation with an immunology physician, for the treatment of patients with previously confirmed hereditary angioedema for: a) Acute attacks of hereditary angioedema, including angioedema affecting the upper respiratory tract and persistent abdominal attack resulting in significant intestinal obstruction; b) Use prior to surgery – significant dental and other surgery; c) During pregnancy for control of attacks; and d) For outpatient use as per the PBS indications.

of 8 ITEM MEDICINE COMMITTEE DATE EFFECTIVE RESTRICTION NUMBER DECISION

13/004 INDOCYANINE GREEN ADDED 30-Apr-13 Surgical consultants, Injection, powder for hepatologists and reconstitution registrars for patients 25mg in 5mL undergoing pre-operative assessment for liver resection. Where an item is not TGA approved, patients should be made fully aware of its status and appropriate consent obtained. 13/018 OSELTAMIVIR ADDED 30-Apr-13 Specialist Staff and PHOSPHATE Powder Country Medical for oral suspension Superintendents on the 6mg/mL, 65mL advice of an Infectious Diseases Physician or a Clinical Microbiologist or in accordance with an Infectious Diseases / Clinical Microbiology approved protocol for: a) Treatment of clinically suspected or laboratory proven influenza in inpatients only (not for general use in Emergency Departments unless admission is intended); and b) Prophylaxis of inpatients who are close contacts of inpatients with laboratory proven influenza on the advice of an infectious diseases physician, clinical

microbiologist or infection control practitioner. Oseltamivir therapy should be ceased if influenza polymerase chain reaction (PCR) test of a nasopharyngeal swab or aspirate is negative. OR In accord with a QH pandemic influenza protocol.

13/013 MYCOPHENOLATE AMENDED 30-Apr-13 Specialist Staff for use in (SODIUM) Tablet accord with Highly 180mg, 360mg Specialised Drugs Program and PBS indications. 13/016 PREGABALIN AMENDED 30-Apr-13 Specialist Staff and CAPSULE Country Medical 25mg, 75mg, 150mg, Superintendents for use 300mg as per the PBS indications for neuropathic pain 13/005 GABAPENTIN AMENDED 30-Apr-13 Specialist Staff and CAPSULE Country Medical 100mg, 300mg, 400mg Superintendents for partial epilepsy not controlled by other drugs; and continuation of existing patients being treated for neuropathic pain. (Note: In early 2014, gabapentin may no

longer be LAM listed for neuropathic pain.)”

13/014A RIVAROXABAN Tablet AMENDED 30-Apr-13 For orthopaedic 10mg prophylaxis of venous thromboembolism in total hip and knee replacement. 13/009 ROCURONIUM AMENDED 30-Apr-13 Emergency Specialists, BROMIDE Injection Specialist Anaesthetists 50mg in 5mL and Country Medical Superintendents 13/006 SUGAMMADEX AMENDED 30-Apr-13 For use by credentialed SODIUM INJECTION anaesthetists and 500mg in 5mL Emergency Physicians for emergency reversal of rocuronium in patients who cannot be intubated or cannot be oxygenated. [Only limited stock may be held outside pharmacy - on the difficult intubation trolley. All other use of sugammadex must be on an individual patient approval basis, with approval by the Director of Anaesthetics, the Director of Emergency Medicine or nominated representative, and in line with the SWAPNET guideline. (Available at http://qheps.health.qld.go

v.au/patientflow/docs/swa pnet_sugam_guide.pdf)]

13/003 HYDROMORPHONE DEFERRED HYDROCHLORIDE Tablet, modified release 4mg, 8mg 12/097 IV 5HT3 DEFERRED ANTAGONISTS FOR USE IN PONV (ONDANSETRON Injection 4mg in 2mL and GRANISETRON Injection 1mg in 1mL) 13/022 LOSARTAN Tablet DEFERRED 25mg, 50mg 13/019 MAGNESIUM SULFATE DEFERRED in Water for Injection 4g/20mL (20%) and 10g/50mL (20%) Pre- filled syringes

12/098 POSTOPERATIVE DEFERRED

NAUSEA AND VOMITING (PONV) Guidelines

13/021 SUCROSE Oral solution DEFERRED 24%, 1.5mL (Phebra) 12/094 TRANEXAMIC ACID DEFERRED INJECTION 100mg/mL, 10mL 13/018 ALCOHOL (ETHANOL) DELETED 30-Apr-13 INJ ABSOLUTE (5.5 Cal per mL) 20mL 13/018 BETAMETHASONE DELETED 30-Apr-13 VALERATE CREAM 0.05%, 30g 13/018 BETAMETHASONE DELETED 30-Apr-13 VALERATE OINTMENT 0.05%, 15g, 30g 13/018 CIMETIDINE DELETED 30-Apr-13 INJECTION 200mg in 2mL 13/018A1 Digoxin immune Fab DELETED 30-Apr-13 (Ovine) Powder for injection 38mg (Digibind®) 13/018 DOCUSATE with DELETED 30-Apr-13 GLYCERIN and SOFT SOAP Enema disposable 5mL 13/018 INDOMETHACIN EYE DELETED 30-Apr-13 DROPS 10mg per mL (1%), 5mL 13/018 NICOTINAMIDE DELETED 30-Apr-13 TABLET 250mg

13/018 OSELTAMIVIR DELETED 30-Apr-13 PHOSPHATE Powder for oral suspension 12mg/mL, 75mL 13/018 PROCAINAMIDE DELETED 30-Apr-13 HYDROCHLORIDE CAPSULE 250mg 13/018 PROCAINE DELETED 30-Apr-13 HYDROCHLORIDE INJECTION 40mg in 2mL (2%) 13/018 STREPTOKINASE DELETED 30-Apr-13 INJECTION 1,500,000 units 13/006 SUGAMMADEX DELETED 30-Apr-13 SODIUM INJECTION 200mg in 2mL 13/020 OMEGA-3-ACID ethyl NOT ADDED esters 90, Capsule 1,000mg 13/008 BOTULINUM TOXIN NOT TYPEAInjection100units AMENDED 13/014 FOR INFORMATION - NOTED FINAL REPORT OF THE REVIEW OF ANTICOAGULATION THERAPIES IN ATRIAL FIBRILLATION