Curriculum Vitae s511

CVSEPTEMBER2016

CURRICULUM VITAE Lynette Ann Denny SEPTEMBER 2016

I am a gynaecologic oncologist and have been working in the field of cervical cancer prevention in collaboration with colleagues from Columbia University, New York since 1995. We began our collaboration with the intention of evaluating alternative strategies for the prevention of cervical cancer in low resource settings. Cervical cancer was and remains the commonest cancer diagnosed among women living in poor countries due to the failure to either initiate or sustain cytology based screening programmes. Our group pioneered the search for alternative protocols for the prevention of cervical cancer in community-based research sites in townships just outside of Cape Town. Since that time I have had extensive research experience in cervical cancer prevention, including three cross-sectional studies comparing different screening tests (such as HPV testing and VIA to cytology), a prophylactic HPV vaccine trial in HIV positive women and a therapeutic vaccine trial in HPV negative women. We are currently engaged in a NCI funded trial evaluating screen and treat with the HPV Xpert Cepheid HPV test. I am still fully functional as a clinician in all aspects of gynaecology oncology and have recently been appointed the director of the SA Medical Research Council Gynaecological Cancer Research Centre, with 5 years of guaranteed funding.

CURRENT EMPLOYMENT

Full Professor (promoted from Associate Professor January 2006) Department of Obstetrics & Gynaecology University of Cape Town

Principal Specialist (promoted from Senior Specialist September 2007) Department of Obstetrics & Gynaecology Groote Schuur Hospital, Cape Town

Head of Department of Obstetrics and Gynaecology, January 2010

1 | P a g e CVSEPTEMBER2016

EMPLOYMENT HISTORY

Position Place Period Internship Groote Schuur Hospital Jan 1984 – Dec 1984

Senior House Officer, Red Cross Children’s Jan 1985 – July 1985 Paediatrics Hospital, Cape Town

Assistant to General Athlone, Cape Town Aug 1985 – July 1986 Practice

Senior House Officer Obstetrics & Gynaecology Aug 1986 – Jan 1987 Groote Schuur Hospital

Senior House Officer Casualty, Department of Feb 1987 – July 1987 Medicine, Groote Schuur Hospital

General Practice Kupat Cholim Histadrut, Mar 1988 – Oct 1988 Neve Monoson, Tel Aviv, Israel

General Practice Kensington, Cape Town Jan 1989 – July 1989

Registrar Obs & Gynae, Groote Schuur Hospital Aug 1989 – Jan 1993 including 18 months as senior registrar in sub- speciality training in Gynaecology Oncology

Specialist Obstetrics & Gynaecology Feb 1994 – Jan 1997 Groote Schuur Hospital

Senior Specialist Obstetrics & Gynaecology Feb 1997 – Aug 2007 Groote Schuur Hospital

Principal Specialist Obstetrics & Gynaecology Sept 2007 – December Groote Schuur Hospital 2009

Chief Specialist Obstetrics & Gynaecology Jan 2010 – present Groote Schuur Hospital

QUALIFICATIONS

MB ChB (UCT) 1983

FCOG (SA) 1993

MMed (O&G) (UCT) 1994 Does Colposcopically directed punch biopsy reduce the incidence of negative LLETZ?

PhD (UCT) 2000 Evaluation of Alternative Strategies for the Prevention Of Cervical Cancer in Low-Resource Settings

10 RECOGNITION FROM PEERS

Honours, Awards and Prizes

1983 Cuthbert Crichton Prize and Class Medal for best sixth year MBChB student in Obstetrics and Gynaecology, University of Cape Town

1993 Cecil Craig Registrar Prize for outstanding performance, Dept of Obstetrics & Gynaecology, University of Cape Town

1996 JC Coetzee Prize for best original research in Obstetrics & Gynaecology, University of Cape Town

1998 Alan Pifer Award for Research that benefits disadvantaged communities, University of Cape Town

2000 Yvonne Parfitt award for best publication, Department Obstetrics & Gynaecology, University of Cape Town

2001 White Ribbon Award for work in combating violence against women and children, Women Demand Dignity

2002 CME Journal: Annual award to the Guest Editor who has contributed the most to the CME Journal for the year 2002 (with Dr Claire Jamieson), South African Medical Journal

2003 First recipient of the Shoprite/Checkers/SABC 2 South African Woman of the

Year award in the category of Science and Technology, Cape Town

2004 Order of the Disa: Member for noteworthy meritorious service in the interest of the Province of the Western Cape, Provincial Government of Western Cape

2004 Recognised by National Department of Health for contributions to the public health sector in terms of service delivery – awarded certificate by Minister of Health, National Department of Health, South Africa

2004 University of Witswatersrand Gynaecology Oncology Prize, Department of Obstetrics & Gynaecology, University of Witswatersrand, Johannesburg

2004 Yvonne Parfitt Prize for Best Publication, Department of Obstetrics & Gynaecology, University of Cape Town

2004 Pioneer for Peace and Human Dignity in recognition of heartfelt support given to abused women and children in the communities in and around Cape Town. MOSAIC Training, Service & Healing Centre for Women

2006 Distinguished Scientist for Improvement of Quality of Life of Women Awarded by Department of Science and Technology, South Africa

2006 JC Coetzee Prize for best original research in Obstetrics & Gynaecology, University of Cape Town

2008 Nominated for German Africa Award 2008 Honorary Member German Society of Obstetrics & Gynaecology (Sept 2008)

2008-2014 The International Journal of Gynecological Cancer Award for devoted service as Senior Editor

2009 Boet Dommisse Award for Special Contributions to the Department, Department of Obstetrics and Gynaecology, University of Cape Town

2009 2 Military Hospital Excellence Service Certificate for excellent and praiseworthy service in your field. Your sincere commitment towards the patients and staff of 2 Military Hospital is recognised and appreciated.

2010 Yvonne Parfitt Prize for Best Publication, Department of Obstetrics and Gynaecology, University of Cape Town

2012 Awarded Fellowship ad eundem of Royal College of Obstetricians and Gynaecologists, London, UK

2012 South African Medical Association (SAMA) award for Extra-Ordinary Service to Medicine

2014 BSCCP Founders’ Medal in recognition of the outstanding work to women’s health and the prevention of cervical cancer in Africa. London, United Kingdom

2014 Institute of Infectious Disease and Molecular Medicine certificate for distinguished contributions to the IDM in financial sustainability, UCT

2014 International Journal of Gynecological Cancer Award for Devoted Service from 2008– 2014 as Senior Editor

2015 South African Medical Research Council award for an application for a Cancer Research Centre titled “MRC/UCT Gynaecological Cancer Research Centre”

2015 National Science & Technology Forum-BHP Billiton Award. Finalist in the Category: TW Kambule Award: Research and its outputs over the last 5 – 10 years by an individual.

2015 CANSA AG Oettle Memorial Award for Contributions to the fight against Cancer in South Africa September 2015

2015 FIGO Award in Recognition of Women Obstetricians/Gynaecologists, presented at XXI FIGO World Congress, Vancouver, Canada, October 2015

2016 International Agency for Research on Cancer (IARC) Medal of Honour, in recognition of outstanding contributions to cancer research, particularly in relation to work on cervical cancer prevention among disadvantaged communities, presented at IARC Conference on Global Cancer, Lyon, France, June 2016.

2016 International Gynecologic Cancer Society (IGCS) Global Humanitarian Award, presented at the 16th Biennial IGCS meeting, Lisbon, Portugal, 2016.

SCHOLARLY ACTIVITIES

*National Research Foundation Rating: B2 (2012)

Editorial Activities:

 Senior Editor: International Journal of Gynaecologic Cancer since 2003 to present

 Editorial Board: Gynecologic Oncology 2005

 Co – editor with Professor Hextan Ngan of Supplement to International Journal of Gynecology and Obstetrics, published November 2006 entitled ‘Prevention and treatment of HPV Associated Disease in the HPV Vaccine Era’.

 Editor of Best Practice and Research: Clinical Obstetrics & Gynaecology. Screening for Gynaecological Cancers, Volume 26 (2), April 2012

 Editor of Monograph on HPV related Disease in Sub-Saharan Africa, Vaccine, 2013

 Editor of Gynecologic Oncology Research and Practice, 2014 – current

 Guest Editor of Best Practice and Research: Clinical Obstetrics & Gynaecology. Human Papilloma Virus in Gynaecology, Issue 32.2, June 2016

Reviewing Activities:

 Local journals

South African Medical Journal Agenda

 International

Cancer International Journal of Cancer

American Journal of Obstetrics and Gynecology, International Journal of Gynecological Cancer Cancer Causes and Control British Journal of Obstetrics and Gynaecology Journal of Women’s Health International Journal of Gynecology and Obstetrics Lancet Oncology Cancer Therapy Gynecology Oncology New England Journal of Medicine Reproductive Health Matters Biomed Central Women’s Health Lancet Infectious Diseases New England Journal of Medicine Clinical Infectious Diseases Gynecologic Research and Practice

 Reviewer Research Organisations:

Research Ethics Committee, University of Cape Town Medical Research Council of South Africa National Research Foundation CARISA Irish Aid, Department of Foreign Affairs, Global Health Research Awards World Health Organisation Cancer Association of South Africa European Union UICC (International Union for Cancer Control) NCI (National Cancer Institute, USA)

Participating Author International Agency Research on Cancer (IARC) for two monographs:

IARC Handbooks of Cancer Prevention, Volume 10. Cervical Cancer Screening. IARC Press, Lyon, 2005

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 90. Human Papillomaviruses. 2007

Participating Author World Health Organisation (WHO) for the following publications:

Cervical Cancer Screening in Developing Countries: A report of a WHO consultation. March 2001 (published)

Cervical cancer screening in Middle-income countries: A report of a WHO consultation March 2002 (published)

Comprehensive Guidelines for Management of Cervical Cancer Prevention Programmes (published 2006 and updated 2012)

Participant in Consultation of the Human Papillomavirus Expert Advisory Group (HEAG) for WHO, Geneva, 3 – 5 September 2007

Role of Temporary Advisor

Membership of Scientific Programme Committees for International Conferences:  International Gynecology Cancer Society 2002, 2004, 2006, 2008, 2010, 2012 European Society of Gynecology Oncology September 2005 African Organisation for Research and Training in Cancer (AORTIC)  November 2005: 5th International Conference Cancer in Africa, A Call to Action, in Dakar, Senegal. Chair of Organising Committee, fund raising and Scientific Programme Committee  October 2007: 6th International Conference: Cancer in Africa, Challenges and Opportunities. Chair of Local Organising Committee and member of Scientific Programme Committee, fundraising and overall organisation  November 2009: 7th International Conference: Cancer the New Reality: Organiser and member of Scientific Programme committee and in charge of fundraising R6.5 million, overall organisation and scientific programme development for conference held in Dar Es Salaam, Tanzania  November/December 2011: 8th International Conference: Entering the 21st Century for Cancer Control in Africa. Organiser and Member of Scientific Programme Committee for the conference held in Cairo  November 2013: 9th International Conference: Cancer in Africa: Bridging Science and Humanity, held in Durban, South Africa

 November 2915: 10th International Conference: Roadmap to Cancer Control in Africa, held in Marrakech, Morocco.

International Papillomavirus Society Meeting: Scientific Programme Committee 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016 EUROGIN Annual Meeting: Scientific Programme Committee 2008, 2009, 2010. 2011, 2012 11

Visiting Professorships

 University of Sao Paulo, Department of Obstetrics and Gynaecology, Brazil and Ludwig Institute for Cancer Research, Sao Paulo, Brazil October 2000

 Women’s Hospital, Department Obstetrics & Gynaecology, Doha, Qatar December 2003

- Royal Women’s Hospital, University of Melbourne Australia, Division of Gynaecology Oncology, Department of Obstetrics & Gynaecology, March 2007

Chair of International Committee for Development of International Guidelines of FIGO (International Federation of Gynaecology and Obstetrics):

 Chairperson of the International Federation of Obstetricians and Gynecologists (FIGO) special sub-committee called the FIGO HPV Study Group. The group formulated evidence- based guidelines for the 110 national member societies of the FIGO and consisted of 8 members in 2007. Subsequently Committee called Cervical Cancer Prevention Committee and guidelines produced are published on FIGO Website. Committee still active in 2012

 Co-Chair, FIGO Gynaecology Oncology Committee – November 2006 to 2012

 Chair of FIGO Gynaecology Oncology Committee from 2012 - 2015

 Created the FIGO CANCER REPORT (consisting of guidelines for staging and management of all gynaecological cancers by site as well as chapters on Pathology, Chemotherapy and Radiation – published October 2012 and upgraded 2015 – Second Edition.

Chair Task Force for UICC World Cancer Day, February 4, 2010 and Editor of Campaign Report

Chair, Safety Evaluation Committee (SEC) for Microbicide trials of International Partnership for Microbicides (IPM) 2008 – ongoing Chair: Data Safety Monitoring Board (DSMB): HPV Vaccine Trial: two versus three doses conducted in 10 sites in India from 2010 to date

Member: Technical Advisory Group, World Health Organisation, Comprehensive Cervical Cancer Prevention and Treatment Guidelines. Attended meeting in Geneva at WHO April 2012 and participated in updating the book for 2012

Member: Technical Advisory Group, World Health Organisation, Guidelines for Cryotherapy, WHO 2011 (published)

Member: National Cervical Cancer Prevention Policy Group, National Department of Health, 2011 – to date

President: International Society of Gynecologic Cancer, 2012 – 2014

FIGO Representative on UICC TNM Core Committee, May 2013 – 2016

Expert Panel Member : American Joint Committee on Cancer (AJCC), 2014 - present

Member: Western Cape Provincial Clinical Governance Committee, January 2014 - present

Resource Stratification Guidelines for Cervical Cancer, ASCO (American Society of Clinical Oncology), 2014 – present

Resource Stratification Guidelines for Cervical Cancer, NCCN (National Comprehensive Cancer Network), 2015 – 2016.

Past President: International Society of Gynecologic Cancer and member of Executive Council, 2015 – 2016

Chair: Nominating Committee of International Gynecologic Cancer Society, 2016

Hospital/University of Cape Town Faculty of Health Sciences Committees: Combined Clinical Centre (CCCC) Joint Standing Advisory Committee (JSAC) Dean’s Advisory Committee (DAC)

Head: Functional Business Unit for Obstetrics and Gynaecology (FBU) Member of Staff Performance Management System Committee (SPMS) Member of Departmental Research Committee (DRC) Organiser of Grand Rounds

12 RESEARCH PUBLICATIONS

Peer Reviewed Journals (note Impact factors and times cited are as from August 15th, 2016 using WEB of SCIENCE) H Index = 24 (Google Scholar)

INTERNATIONAL

1. Denny LA, Soeters R, Dehaeck K, Bloch B Does colposcopically directed punch biopsy reduce the incidence of negative LLETZ? Br J Obstet Gynaecol 1995; 102(7): 545-8 IF: 2.00 Cited: 38

2. Nevin J, Bloch B, van Wijk L, Soeters R, Dehaeck K, Ball H, Denny LA Primary chemotherapy with bleomycin, ifosfamide and cisplatinum (BIP) followed by radiotherapy in the treatment of advanced cervical cancer. A pilot study. Eur J Gynecol Oncol 1995; 16(1): 30-5 IF: 0.64 Cited: 5

3. Denny LA, Dehaeck K, Nevin J, Soeters R, van Wijk L, Megevand E, Bloch B Placental site trophoblastic tumor: three case reports and literature review. Gynecol Oncol 1995; 59(2): 300-3 IF: 3.774 Cited: 39

4. Megevand E, Denny LA, Soeters R, Nevin J, Dehaeck K, Bloch B The influence of hormonal status on excision margins after large loop excision of the transformation zone (LLETZ). Eur J Gynaecol Oncol 1995; 17(3): 223-7 IF: 0.64 Cited: 6

5. Megevand E, Denny LA, Dehaeck K, Soeters R, Bloch B Acetic acid visualization of the cervix: an alternative to cytologic screening. Obstet Gynecol 1996; 88(3): 38386 IF: 5.175 Cited: 141

6. Nevin J, Denny LA, Megevand E, van der Merwe E, Hendricks S The role of vasoconstrictor therapy in cold knife cone biopsy. J Gynecol Techniques 1996; 2: 12933 Cited: 0

7. Kuhn L, Denny LA, Pollack A, Wright TC Prevalence of visible disruption of cervical epithelium and cervical ectopy in African women using Depo-Provera. Contraception 1999; 59(6): 363–67 IF: 2.335 Cited: 23

8. Wilder- Smith C, Hill L, Wilkins J, Denny LA Effects of morphine and tramadol on somatic and visceral sensory function and gastrointestinal motility after abdominal surgery. Anesthesiology 1999; 91(3): 639–47 IF: 5.879 Cited: 0

9. Kuhn L, Denny LA, Pollack A, Lorincz A., Richart R., Wright TC Human Papillomavirus DNA Testing for Cervical Cancer Screening in Low Resource Settings. J Natl Cancer Inst 2000; 92: 818-25 IF: 11.370 Cited: 482

10. Wright TC, Denny LA, Kuhn L, Pollack A, Lorincz A HPV DNA testing of Self-collected Vaginal Samples Compared with Cytologic Screening to Detect Cervical Cancer. JAMA 2000; 283: 81-86 IF: 37.684 Cited: 255

11. Marais DJ, Rose RC, Lane C, Kay P, Nevin J, Denny LA et al. Seroresponses to Human Papillomavirus Types 16, 18, 31, 33, and 45 Virus-Like Particles in South African Women with Cervical Cancer and Cervical Intraepithelial Neoplasia. J Med Virol 2000; 60(4): 403–410 IF: 1.998 Cited: 28

13. Denny LA, Kuhn L, Risi L, Richart R, Pollack A, Lorincz A, Kostecki F, Wright TC Two Stage Cervical Cancer Screening: an alternative for resource-poor settings. Am J Obstet Gynecol 2000; 183(2): 383–88 IF: 4.704 Cited: 61

14. Denny LA, Kuhn L, Pollack A, Wainwright H, Wright TC. Evaluation of Alternative Methods of Cervical Cancer Screening for Resource-Poor Settings. Cancer 2000; 89(4): 826–33 IF: 5.649 Cited: 219

15. Marais DJ, Best JM, Rose RC, Keating P, Soeters R, Denny LA. et al. Oral antibodies to human papillomavirus type 16 in women with cervical neoplasia. J Med Virol 2001; 65(1): 149–54 IF: 1.998 Cited: 0

16. Goldie S, Kuhn L, Denny LA, Pollack A, Wright TC Policy analysis of cervical cancer – Screening Strategies in Low Resource Settings. JAMA 2001; 285 (24): 3107–115 IF: 37.684 Cited: 306

17. Denny LA , Kuhn L, Pollack A, Wright TC Direct Visual Inspection for Cervical Cancer Screening: An analysis of factors influencing test performance. Cancer 2002; 94(6): 1699–1707 IF: 5.649 Cited: 159

18. Wright TC, Denny LA, Kuhn L, Goldie S Use of visual screening methods for cervical cancer screening. Obstet Gynecol Clin N Am 2002; 29: 701–33 IF: 1.703 Cited: 26

19. Wensveen C, Kagie M, Veldhuizen R. De Groot C, Denny LA, Zwinderman K, Trimbos B Detection of cervical intraepithelial neoplasia in women with atypical squamous or glandular cells of undetermined significance cytology: A prospective study. Acta Obstet Gynecol Scand 2003; 82(9): 883-89 IF: 0.30 Cited: 5

20. Kim J C, Martin LJ, Denny LA Rape and HIV Post-Exposure Prophylaxis: Addressing the Dual Epidemics in South Africa. Reproductive Health Matters 2003; 11(22): 101-112 IF: 1.855 Cited: 59

21. Shapiro S, Rosenberg L, Hoffman M, Kelly JP, Cooper DD, Carrara H, Denny LA

du Toit G, Allan B, Stander I & Williamson A. Risk of invasive cancer of the cervix in relation to the use of injectable progestogen contraceptives and combined estrogen/progestogen oral contraceptives (South Africa). Cancer Causes and Control 2003; 14: 485-495 IF: 2.735 Cited: 32

22. M Hoffman , D Cooper, H Carrara, L Rosenberg, J Kelly, I Stander, A L Williamson, LA Denny, G du Toit and S Shapiro Limited Pap screening associated with reduced risk of cervical cancer in South Africa. International Journal of Epidemiology 2003; 32(4): 573–77 IF: 7.522 Cited: 19

23. Denny LA, Louise Kuhn, Thomas C Wright Cervical cancer screening in non-industrialised countries. Papillomavirus Report 2003; 14: 209–215 IF: 0.44 Cited: 0

24. Landon Myer, Denny LA, Michelle De Souza, Mark Barone, Thomas C Wright, Louise Kuhn Intravaginal Practices, HIV and Other Sexually Transmitted Diseases Among South African Women. Sex. Trans. Dis 2004; 31(3): 174-9 IF: 0.40 Cited: 41

25. PL Semple, Denny LA, M Coughlan, R Soeters, L Van Wijk The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases. Int J Gynecol Cancer 2004; 14(1): 157-161 IF: 2.116 Cited: 16

26. Bradley J. Risi L, Denny LA Widening the cervical cancer screening net in a South African township: who are the underserved? Health Care for Women International 2004; 25(3): 227-241 IF: 0.802 Cited: 20

27. Risi L, Bindman JP, Campbell OMR, Imrie J, Everett K, Bradley J, Denny LA Media Interventions to increase cervical screening uptake in South Africa: an evaluation study of effectiveness. Health Education Research 2004; 19(4): 457–68

IF: 1.66 7 Cited: 19

28. Denny LA. The prevention of cervical cancer in developing countries. BJOG: an International Journal of Obstetrics & Gynaecology 2005; 112(9): 1204–1212 IF: 3.407 Cited: 74

29. Myer L, Denny LA, Telerant R, De Souza M, Wright TC, Kuhn L Bacterial vaginosis and susceptibility to HIV infection among South African women: a nested case-control study. Journal of Infectious Diseases 2005; 192(8): 1372–80 IF: 6.344 Cited: 167

30. Denny LA, Wright TC Human papillomavirus testing and screening. Best Practice & Research Clinical Obstetrics & Gynaecology 2005; vol 19, no. 4: pp 501– 515 IF: 2.97 Cited: 55

31. Kay P, Allan B, Denny L, et al. Detection of HPV 16 and 18 DNA in the blood of patients with cervical cancer. J Med Virol 2005; 75(3): 435–439 IF: 1.998 Cited: 15

32. Denny LA, Louise Kuhn, Michelle De Souza, Amy Pollack, William Dupree, Thomas C Wright Screen-and-Treat Approaches for Cervical Cancer Prevention in Low-Resource Settings. JAMA 2005; 294(17): 2173–81 IF: 37.684 Cited: 222

33. Myer L, Kuhn L, Stein ZA, Wright TC, Denny LA. Intravaginal practices, bacterial vaginosis, and women’s susceptibility to HIV infection: epidemiological evidence and biological mechanisms. Lancet Infect Dis 2005; 5(12): 786-94 IF: 19.446 Cited: 123

34. Jeremy D Goldhaber-Fiebert, Denny LA, Michelle De Souza, Thomas C Wright Jr, Louise Kuhn, Sue J Goldie The costs of reducing loss to follow up in South African cervical cancer screening. Cost effectiveness and Resource Allocation 2005; 3: 11

Cited: 15

35. Sylvia Taylor, Louise Kuhn, William Dupree, Lynette Denny, Michelle De Souza, and Thomas C Wright. Direct comparison of liquid-based and conventional cytology in a South African Screening Trial. Int J Cancer 2006; 118(4): 957-62 IF: 5.085 Cited: 26

36. Jennifer R Moodley, Margaret Hoffman, Henri Carrara, Bruce R Allan, Diane D Cooper, Lynn Rosenberg, Lynette Denny, Samuel Shapiro and Anna-Lise Williamson (2006) HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case control study. BMC Cancer 2006; 6: 135 IF: 3.362 Cited: 135

37. Diane J Marais, Candice Sampson, Anthea Jeftha, Dherendra Dhaya, Jo-Ann Passmore, Lynette Denny, Edward P Rybicki, Eric Van De Walt, Lawrence X G Stephen and Anna- Lise Williamson More men than women make mucosal IgA antibodies to Human Papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population. BMC Infectious Diseases 2006; 6: 95 IF: 2.290 Cited: 19

38. Tu JJ, Kuhn L, Denny L, Beattie KJ, Lorincz A, Wright TC Jr. Molecular variants of human papillomavirus type 16 and risk for cervical neoplasia in South Africa. Int J Gynecol Cancer 2006; 16(2): 736–42 IF: 2.116 Cited: 9

39. *Myer L, Denny L, De Souza M, Wright TC Jr., Kuhn L. Distinguishing the temporal association between women’s intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African women. Am J Epidemiology 2006; 163(6): 552–60 IF: 5.230 Cited: 32

40. Pollack A, Balkin MS, Denny L Cervical cancer: A call for political will.

Int J Gynaecol Obstet. 2006; 94(3): 333-42 IF: 1.674 Cited: 7

41. Lynette Denny, Michael Quinn, R Sankaranarayanan Chapter 8: Screening for cervical cancer in developing countries. Vaccine 2006; 24S3: S3/71 – S3/77 IF: 3.624 Cited: 121

42. L Denny, H YS Ngan Chapter 4, Section B: Malignant manifestations of HPV infection. Carcinoma of the cervix, vulva, vagina, anus and penis. Int J Gynecol Obstet 2006; 94 (suppl 1): S50 – S55 IF: 1.674 Cited: 6

43. L Denny, R Sanakaranarayanan Chapter 6. Secondary Prevention of Cervical Cancer. Int J Gynecol Obstet 2006; 94 (suppl 1): S65 – S70 IF: 1.674 Cited: 5

44. LL Villa, L Denny Chapter 7. Methods for detection of HPV infection and its clinical utility. Int J Gynecol Obstet 2006; 94 (supplement 1): S71 – S80 IF: 1.674 Cited: 25

45. L Denny. Cervical Cancer: The South African Perspective. Int J Gynecol Obstet 2006; 95: S211–S214 (suppl 1): 26th Annual Report on the Results of Treatment on Gynecological Cancer IF: 1.674 Cited: 10

46. Jo-Ann Passmore, Michelle Milner, Lynette Denny, Candice Sampson, Dianne J Marias, Bruce Allan, et al Comparison of cervical and blood T-cell responses to human papillomavirus -16 in women with human papillomavirus – associated cervical intra-epithelial neoplasia. Immunology 2006; 119(4): 507–514 IF: 3.705 Cited: 15

47. Myer L, Wright TC Jr, Denny L, Kuhn L. Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South Africa.

Sex Transm Dis 2006; 33(11): 683 –7 IF: 0.40 Cited: 34

48. Myer L, Kuhn L, Denny L et al Recurrence of symptomatic bacterial vaginosis 12 months after oral metronidazole therapy in HIV-positive and –negative women. J Infect Diseases 2006; 194(12): 1797–99 IF: 5.997 Cited: 9

49. Allan BR, Marais DJ, Denny L, Hoffman M, Shapiro S, Williamson AL The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus. S Afr Med J 2006; 96(11): 1186-90 IF: 1.325 Cited: 21

50. Henry Kitchener, Linsey Nelson, Joanna Adams, David Mesher, Peter Sasieni, Heather Cubie, Catherine Moore, Isabelle Heard, Alberto Agarossi, Elena Casolati, Lynette Denny, Caroline Bradbeer, Fiona Lyons, Gerry Beattie and Tomasz Niemiec (2007) Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: An international cohort study of cervical pathology in HIV-1 positive women. Int J Cancer 2007; 121(11): 2484-2491 IF: 5.085 Cited: 22

51. Cooper D, Hoffman M, Carrara H, Rosenberg L, Kelly J, Stander I, Denny L, Williamson AL, Shapiro S Determinants of sexual activity and its relation to cervical cancer risk among South African women. BMC Public Health, 2007; 7(1); 341 IF: 2.209 Cited: 14

52. Wright TC Jr, Blumenthal P, Bradley J, Denny L, Esmy PO, Jayant K, Nene BM, Pollack AE, Rajkumar R, Sankaranarayanan R, Sellors JW, Shastri SS, Sherris J, Tsu V Cervical cancer prevention for the world’s women: New approaches offer opportunities and promise. Diagn Cytopathol. 2007; 35 (12): 845-8 IF: 0.98 Cited: 12

53. Sherris J, Wright TC Jr, Denny L, Sanakaranarayanan R, Pollack AE, Sanghvi H, Sellors JW. Alliance for cervical cancer prevention: setting the record straight. Am J Public Health 2007; 97(2): 200-1

IF: 4.552 Cited: 6

54. Myer L, Denny L, Wright TC, Kuhn L. Prospective study of hormonal contraception and women’s risk of HIV infection in South Africa. Int J Epidemiol 2007; 36(1): 166–74 IF: 9.197 Cited: 19

55. Zhang Q, Kuhn L, Denny LA, De Souza M, Taylor S, Wright TC Jr. Impact of utililizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening tests. Int J Cancer 2007; 120(2): 35 –6 IF: 5.085 Cited: 26

56. Cain J, Denny L, Ngan HY Overcoming barriers to the eradication of cervical cancer: women’s health and rights. Int J Gynaecol Obstet 2007; 97(3): 232-4 IF: 1.674 Cited: 5

57. Duma SE, Mekwa JN, Denny LA Women’s journey of recovery from sexual assault trauma: a grounded theory – Part 1 and Part 2. Curationis 2007; 30(4): 4 – 11 and 12 20 IF: 1.115 Cited: 1

58. Mbulawa ZZ, Williamson AL, Stewart D, Passmore JA, Denny L, Allan B et al. Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical disease. J Gen Virol 2008; 89(Pt 4): 910–14 IF: 3.192 Cited: 10

59. Marais DJ, Passmore J, Denny L, Sampson C, Allan BR, Williamson AL Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South Africa. J Med Virol 2008; 80(6): 953–9 IF: 1.998 Cited: 23

60. *Lynette Denny, Rosalind Boa, Anna-Lise Williamson, Bruce Allan, Diane Hardie, Stan Ress and Landon Myer

Human papillomavirus infection and cervical disease in Human Immunodeficiency virus- 1 infected women. Obstet Gynecol 2008; 111(6): 1380–87 IF: 5.175 Cited: 59

61. Lynette Denny Preventing Cervical cancer in developing countries. Therapy 2008; 5(3): 329-338 Cited: 1

62. Gumbi PP, Nkwanayana NN, Bere A, Burgers WA, Gray CM, Williamson AL, Hoffman M, Coetzee D, Denny L, Passmore JA Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1) specific CD8 T-cell responses in the female genital tract during chronic HIV infection. J Virol 2008; 82(17): 8529–36 IF: 4.69 Cited: 27

63. van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD. The Karyopherin proteins. Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer 2009; 124: 1829–1840 IF: 5.531 Cited: 47

*(Reprint of article that appeared in South African Health Review, 2006). Lynette Denny. Prevention of Cervical Cancer Reproductive Health Matters 2008; 16 (32): 18–3163. IF: 1.221 Cited: 8

64. *L Denny The burden of disease associated with infection with human papillomavirus. Afr J Urology 2009; 15(1): 1–6 IF: 0.14 Cited: 0

65. Jeremy Goldhaber-Fiebert, Lynette Denny, Michelle De Souza, Louise Kuhn, Sue Goldie Program Spending to Increase Adherence: South African Cervical Cancer Screening. PLoS ONE 2009; 4(5): e5691.doi:10.1371/journal.pone.0005691 IF: 3.057 Cited: 3

66. Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, et al.

Impact of human immunodeficiency virus-1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital. Immunology 2009; 128 (1 Suppl): e 746–57 IF: 4.078 Cited: 21

67. Lynette Denny Human Papillomavirus Infections: Epidemiology, Clinical Aspects and Vaccines. The Open Infectious Diseases Journal 2009; 3: 135–42 IF: 0.29 Cited: 1

68. Alfred Bere, Lynette Denny, Wendy Burgess, Jo-Ann Passmore Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract to improve the recovery of cervical cytobrush- derived T cells from the female genital tract. J Immune Methods 2010; 130: 23-33 IF: 1.64 Cited: 6

69. Lenine J Liebenberg, Adebayo Adedeji, Darren P Martin, Pam P Gumbi, Lynette Denny, Jo-Ann Passmore (2009) CD 57 expression by T Cells in the female genital tract of HIV-1 infected women. Clin Immun 2010; 135: 137-145 IF: 3.094 Cited: 3

70. Taylor S, Wang C, Wright TC, Denny L, Tsai W-Y, Kuhn L. Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa. BMC Medicine 2010; 8: 40-48 IF: 7.249 Cited: 9

71. Kuhn L, Wang C, Tsai WY, Wright TC, Denny L. Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women. AIDS 2010; 24: 1-9 IF: 5.554 Cited: 26

72. Denny L, Kuhn L, Hu C-C, Tsai W-Y, Wright TC. Human Papillomavirus-Based Cervical Cancer Prevention: Long-term Results of a Randomized Screening Trial. J Natl Cancer Inst 2010; 102: 1-11 IF: 11.370 Cited: 53

73. Mkhize NN, Gumbi PP, Liebenberg LJ, Ren Y, Smith P, Denny L, Passmore JA. Persistence of genital tract T cell responses in HIV-infected women on highly active antiretroviral therapy. J Virol 2010; 84(20): 10765-72 IF: 5.076 Cited: 4

74. Bere A, Denny L, Hanekom W, Burgers WA, Passmore JA. Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women. J Immune Methods, 2010; 354:(1-2): 68-79 IF: 1.64 Cited: 10

75. Taylor S, Wang C, Wright TC, Denny L, Kuhn L. A comparison of HPV testing of clinician-collected and self-collected samples during follow-up after screen-and-treat. Int J Cancer 2010; 129(4): 879-886 IF: 5.085 Cited: 6

76. Wang C, Wright TC, Denny L, Kuhn L. Rapid Rise in Detection of Human Papillomavirus (HPV) Infection Soon After Incident HIV Infection among South African Women. Journal Infectious Diseases 2011; 203: 479-486 IF: 5.997 Cited: 18

77. Roland ME, Myer L, Martin LJ, Maw A, Batra P, Arend E, Coates TJ, Denny LA. Preventing Human Immunodeficiency Virus Infection Among Sexual Assault Survivors in Cape Town, South Africa: An Observational Study. AIDS Behav, DO1 10.1007/s 10461-011-9892-3 IF: 3.312 Cited: 2

78. Denny L. Cervical cancer treatment in Africa. Curr Opin Oncol 2011; 23: 469-474 IF: 4.466 Cited: 4

79. Tayib S, van Wijk L, Denny L. Gestational Trophoblastic neoplasia and Human Immunodeficieny Virus Infection. A 10-year review. Int J Gynecol Cancer 2011; 21: 1684-1691

IF: 2.116 Cited: 0

80. Denny L. Cytological screening for cervical cancer prevention. Best Practice & Research Clinical Obstetrics & Gynaecology 2012; 26: 189-196 IF: 2.97 Cited: 6

81. Wiebe E, Denny L, Thomas G. Cancer of the cervix uteri. Int Journal Gynecol Obstet 2012; 118: S12- S21 IF: 1.674 Cited: 3

82. Denny L, Anorlu R. Cervical cancer in Africa. Cancer Epidemiology, Biomarkers and Prevention 2012; 21(9): 1434 – 8 IF: 3.622 Cited: 5

83. Denny L. Editor: Monograph on HPV related disease: Sub-Saharan Africa. Vaccine 2012 IF: 3.624 Cited: 0

84. Denny L, Alemany L, De Vuyst H, De Sanjose S. Recommendations for Sub-Saharan Africa. Chapter 6. Vaccine 2012; 11.077 IF: 3.624 Cited: 0

85. Denny LA, Franceschi S, de Sanjose S, Heard I, Moscicki AB, Palefsky J. Human Papillomavirus, Human Immunodeficiency Virus and Immunosuppression. Vaccine 30S 2012; F168-174 IF: 3.624 Cited: 59

86. Lynette Denny. Cervical cancer prevention. New opportunities in primary and secondary prevention in the 21st century. Int Journal Gynecol Obstet 2012; 119: S80–S84 IF: 1.674 Cited: 13

87. Arbyn M, de Sanjose S, Saraiya M, Sideri M, Palefsky J, Lacey C, Gillison M, Bruni L,

Ronco G, Wentzensen N, Brotherton J, Qiao Y-L, Denny L, Bornstein J, Abramowitz K, Giuliano A, Tommasino M, Monsonego J. EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease. Int J Cancer 2012; 131: 1969-1982 IF: 5.531 Cited: 17

88. Denny L. International Perspective on the Global Advances in Gynecologic Cancer. In: Govindan R, ed. 2012 ASCO Educational Book. Alexandria, VA: American Society of Clinical Oncology 2012; 330-334 Cited: 0

89. Denny L. Cervical cancer prevention and treatment. Discovery Medicine 2012; 14(75): 125-131 IF: 3.426 Cited: 10

90. McDonald AC, Denny L, Wang C, Tsai WY, Wright TC, Kuhn L. Distribution of High-risk Human Papillomavirus genotypes among HIV-negative women with and without cervical intraepithelial neoplasia in South Africa. PLoS One, 2012; 7(9): e44332 IF: 3.057 Cited: 5

91. Arends E, Maw A, de Swardt C, Denny LA, Roland M. South African Sexual Assault Survivor’s Experiences of Post-Exposure Prophylaxis and Individualised Nursing Care: a Qualitative Study. Journal of the Association of Nurses in AIDS care 2012; (24 No 12): 154-165 IF: 1.398 Cited: 0

92. Denny L, Sankaranayanan R, De Vuyst H, Kim JJ, Adefuye PO, Alemany L, et al. Recommendations for Cervical Cancer Prevention in Sub-Saharan Africa. Vaccine 2013; Suppl 5: F73-4 IF: 3.624 Cited: 6

93. Morhason-Bello IO, Odedina F, Rebbeck TR, Harford J, Dangou J-M, Denny L, Adewole IF. Challenges and opportunities in cancer control in Africa: a perspective from the African Organisation for Research and Training in Cancer. Lancet Oncol 2013;(14): e142-51 IF: 26.509 Cited: 23

94. Kingham TP, Alatise OI, Vanderpuye V, Casper C, Abantanga FA, Kamara TB, Olopade OI, Habeebu M, Abdulkareem FB, Denny L. Cancer care and surgery in sub-Saharan Africa. Lancet Oncol 2013;(14): e158-67 IF: 26.509 Cited: 21

95. De Vuyst H, Alemany L, Lacey C, Chibwesha CJ, Sahasrabuddhe V, Banura C, Denny L, Parham GP. The burden of HPV infections and related diseases in Sub-Saharan Africa. Vaccine 2013; Suppl 5: F32-46 IF: 3.624 Cited: 12

96. Sankaranarayanan R, Anorlu R, Sandwa-Lugoma G, Denny LA. Infrastructure Requirements for Human Papillomavirus Vaccination and Cervical Cancer Screening in Sub-Saharan Africa. Vaccine 2013; Suppl 5: F47-52. IF: 3.624 Cited: 5

97. Adefuye PO, Broutet NJ, de Sanjose S, Denny LA. Trials and Projects on Cervical Cancer Prevention and Human Papillomavirus in Sub- Saharan Africa. Vaccine 2013; Suppl 5: F53-9

IF: 3.624 Cited: 11

98. Awolude OA,Morhason-Bello IO, Denny LA, Adewole IF. Human Papillomavirus Infection and Related Cancers in Sub-Saharan Africa: Burden and Tools for Prevention. Vaccine 2013; Suppl 5: vii-x IF: 3.624 Cited: O

99. Bere A, Denny LA, Nacker P, Burgers WA, Passmore J-A. HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional. Immunology 2013; 139(3): 342-51 IF: 4.078 Cited: 4

100. Lynette Denny, Jane Kim. European cost-effectiveness analysis of cervical screening strategies for women not vaccinated for HPV: in many scenarios primary HPV screening is preferable to primary cytology screening in women aged over 30 years. Evid Based Nurs 2013;(16): 8-9 IF: 1.762 Cited: 0

101. Belhadj H, Rasanathan JJK, Denny L, Broutet N. Sexual and reproductive health and HIV services: Integrating HIV/AIDS and cervical cancer prevention and control. Int J Gynecol Obstet 2013; 121: S29-30 IF: 1.674 Cited: 7

102. L Denny. Staging of ovarian cancer: time to subdivide more? J Gynecol Oncol 2013; 24: 293-4 IF: 2.15 Cited: 2

103. Denny L, Hendricks B, Gordon C, Thomas F, Hezareh M. Dobbelaere K, et al. Safety and immunogenicity of the HPV-16/18 ASO4-adjuvanted vaccine in HIV- positive women in South Africa: A partially-blind randomised placebo-controlled study. Vaccine 2013;(48): 5745-53 IF: 3.624 Cited: 13

104. Denny L. Safety of HPV vaccination: A FIGO statement. Int J Gynecol Obstet 2013; 123: 187-8 IF: 1.674 Cited: 4

105. Bosch FX, Broker TF, Forman D, Moscicki AB, Gillison ML, Doorbar J, Stern PL, Stanley M, Arbyn M, Poljak M, Cuzick J, Castle PE, Schiller JT, Markowitz LE, Fisher WA, Canfell K, Denny LA, et al. Comprehensive control of human papillomavirus infections and related diseases. Vaccine 2013; Suppl 5: F1-31 IF: 3.624 Cited: 7

106. Lynette Denny, Isaac Adewole, Rose Anorlu, Greta Dreyer, Manivasan Moodley, Trudy Smith, et al. Human papillomarvirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa. Int J Cancer 2014; 134: 1389-98 IF: 5.531 Cited: 0

107. Alfred Bere, Shahila Tayib, Jean-Mari Kriek, Lindi Masson, Shameem Z Jaumdally, Shaun L Barnabas, William H Carr, Bruce Allan, Anna-Lise Williamson, Lynette Denny, Jo-Ann S Passmore. Altered phenotype and function of NK cells infiltrating Human Papillomavirus (HPV)- associated genital warts during HIV infection.

Clin Immunol 2014;150: 210-219 IF: 0.18 Cited: 2

108. David Mutch, Lynette Denny, Michael Quinn. Hereditary gynecologic cancers. Int J Gynecol Obstet 2014;124: 189-92 IF: 1.674 Cited: 4

109. Alicia C McDonald, Ana I Tergas, Louise Kuhn, Lynette Denny, Thomas C Wright. Distribution of human papillomamavirus genotypes among HIV-positive and HIV- negative women in Cape Town, South Africa. Front Oncol 2014;doi:10.3389 IF: 4.66 Cited: 0

110. Denny L. Control of Cancer of the Cervix in Low – and Middle-Income Countries. Ann Surg Oncol 2015;22(3):728-33 IF: 3.655 Cited: 2

111. LA Denny. Questions We Should be Asking about Bevacizumab for Cervical Cancer. Editorial: Liu FE, Cripe J, Tewari KS. Anti-Angiogenesis Therapy in Gynecologic Malignancies. Oncology 2015; 282-294 IF: 2.152 Cited: 1

112. L Denny. HIV and HPV as Fatal Partners. Curr Obstet Gynecol Rep 2015;4:143-8. IF: 1.072 Cited: 0

113. L Denny, N Bhatla.

Preface for Best Practice and Research Clinical Obstetrics and Gynaecology: Staging in Gynaecologic Oncology Clin Obstet Gynecol 2015;29.6:765-6. IF: 1.619 Cited: 0

114. CL Trimble, MP Marrow, KA Kraynyak, X Shen, M Dallas, J Van, L Edwards, R Lamar Parker, L Denny et al. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised. Double-blind, placebo=controlled phase 2b trial. Lancet September 17, 2015;1-11 IF: 39.207 Cited: 0

115. Denny L, Prendiville W. Cancer of the cervix: Early detection and cost-effective solutions. Int J Gynecol Obstet 2015; 131:S28-S32. IF: 1.674 Cited: 0

116. H Gelband, R Sankaranarayanan, CL Gauvreau, S Horton, BO Anderson, F Bray, J Cleary, AJ Dare, L Denny et al. The costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities, 3rd edition. Lancet 2016; 387:2133-2144. IF: 39.207 Cited: 0 117. N Mbatani, T Adams, L van Wijk, C Behrens, T Tam, T Wright, M Stoler, L Denny. Performance of an Human Papillomavirus Test in Samples from Women with Histolopathologically confirmed Invasive Cervical Cancer. J Lower Gen Tract Dis 2016;20:151-153 IF: 1.936

118. Nancy Santesso, Reem A Mustafa, Holger J Schunemann, Marc Arbyn, Paul Blumenthal, Joanna Cain, Michael Chirenje, Lynette Denny et al. World Health Organization Guidelines for treatment of cervical intraepithelial neoplasia 2-3 and screen-and-treat strategies to prevent cervical cancer. Int J Gynecol Obstet 2016;132:252-258. IF: 1.674 Cited: 0

119. J-M Kriek, SZ Jaumdally, L Masson, F Little, Z Mbulwa, Pamela P Gumbi, Shaun L Barnabas, J Moodley, L Denny et al. Female genital tract inflammation, HIV co-infection and persistent mucosal Human Papillomavirus (HPV) infections. Virology 2016;493: 247-254. IF: 2.181

120. Lynette Denny. Epidemiology and Burden of Disease Associated with HPV infection. Curr Obstet Gynecol Rep 2016;5: 189-195. IF: 1.072

121. L Denny, S de Sanjose, M Mtuebi, BO Anderson, J Kim, et al. Interventions to close the divide for women with breast and cervical cancer. Lancet 2016 IF: 39.209 Cited: 0

122. T Adams, L Denny. Abnormal vaginal bleeding in women with gynaecological malignancies Best Practice & Research: Clinical Obstetrics & Gynaecology, Issue 32.2 IF: 2.97

LOCAL PEER REVIEWED PUBLICATIONS 1. Nevin J, Van Wyk E, Denny LA, Megevand E, James M (1999) Blood Ordering Practices in the Management of Ectopic Pregnancy at Groote Schuur Hospital.

S Afr Med J 1999; 89: 1003–1005 IF: 1.712 Cited: 0

2. Lynette Denny HPV Vaccination. S Afr J Child Health 2008, 2(4): 142-3 IF: 2.042 Cited: 0

3. Lynette Denny Cervical Intraepithelial Neoplasia. S Afr J Gyn Oncology, 2009; 1: 1 Cited: 0 4. Batra P, Kuhn L, Denny L. Utilisation and outcomes of cervical cancer prevention services among HIV-infected women in Cape Town S Afr Med J 2010; 100(1): 39–44 IF: 1.712 Cited: 9

5. Van Der Spuy Z, Dyer SJ, Jeffery ST, Denny LA. The gynaecological subspecialities: advances in women’s health. S Afr Med J 2012; 102 (6): 419-421 IF: 1.712 Cited: 0

6. I Moodley, N Tathiah, V Mubaiwa, L Denny. High uptake of Gardasil vaccine among 9 – 12-year old schoolgirls participating in an HPV vaccination demonstration project in KwaZulu-Natal, South Africa. S Afr Med J 2013; 103 (5): 319-321. IF: 1.712 Cited: 20

7. N Tathiah, I Moodley, V Mubaiwa, L Denny, M Taylor. South Africa’s nutritional transition: Overweight, obesity, underweight and stunting in female primary school learners in rural KwaZulu-Natal, South Africa.

S Afr Med J 2013; 103: 718-723. IF: 1.712 Cited: 6

8. N Tathiah, I Moodley, L Denny, J Moodley, W Jassat. Cervical cancer in South Africa: challenges and opportunities. SAHR 2014; 117-125. IF: 1.712

9. S Tayib, B Allan, A-L Williamson, L Denny. Human papillomavirus genotypes and clinical management of genital warts in women attending a colposcopy clinic in Cape Town, South Africa. S Afr Med J 2015;105(8):679-684. IF: 1.712 Citied: 1

13 CHAPTERS IN BOOKS

1. Denny LA (1994) Care of the terminally ill patient. In: Manual of Practical Gynecological Oncology Eds: Bloch B, Dehaeck K, Soeters R. London: Chapman & Hall, pp 159-170

2. Robbert Soeters and Lynette A Denny (1998) Cancer of the Uterus. In: Essentials of Gynaecological Cancer. Eds: Lawton F, Friedlander M, Thomas G. London: Chapman & Hall, pp 157-171

3. Lynette Denny Gynaecology In: Handbook of HIV Medicine. Eds: D Wilson, S Naidoo, L Bekker, M Cotton, G Maartens. Oxford University Press, Southern Africa, pp 225–231

4. Lynette Denny Rape In: Handbook of HIV Medicine. Eds: D Wilson, S Naidoo, L Bekker, M Cotton, G Maartens. Oxford University Press, Southern Africa, pp 232–234

5. Lynette Denny The cervix In: Handbook of Obstetrics and Gynaecology. Eds: Z M Van Der Spuy and John Anthony. Oxford University Press, Southern Africa, pp 361-369

6. Lynette Denny Violence against women In: Handbook of Obstetrics and Gynaecology. Eds: Z M Van Der Spuy and John Anthony. Oxford University Press, Southern Africa, pp 392-395

7. Thomas C Wright, Lynette Denny and Amy Pollack (2003) Strategies for Overcoming the Barriers to Cervical Cancer Screening in Low-Resource Settings. In: Gynecology & Obstetrics looseleaf Vol 27, Chapter 33 pp 1- 25

8. Lynette Denny Chapter 10. Prevention of Cervical Cancer. South African Health Review, Nov 2006

9. Krebs H, Denny L, Global Library of Women’s Medicine. (ISSN: 1756 – 2228) 2008, DOI 10.3843/GLOWM 10226

10. Denny L. Screening for cervical cancer in resource-limited settings. In: UpToDate, Basow DS (Ed), UpToDate, Waltham, MA, 2012.

11. Susan Zweizig, Sarah Hughes, Lynette Denny, Joanna Cain. Chapter 34. End-of-Life Care. In: Principles and Practice of Gynecologic Oncology, Richard L Barakat, Andrew Berchuck, Maurice Markman, Marcus E Randall (Eds). Lippincott Williams & Wilkins.

12. Lynette Denny, Rolando Herrero, Carol Levin, Jane J Kim. Chapter 4. Cervical Cancer. In: Disease Control Priorities. Third Edition, Hellen Gelband, Prabhat Jha, Rengaswamy Sankaranarayanan, Susan Horton (Eds). 2015.

13. Lynette Denny, Leon van Wijk. Chapter 35. Cervix. In: UICC Manual of Clinical Oncology. Ninth Edition, Brian O’Sullivan, James D Brierley, Anil K D’Cruz, Martin F Fey, R Pollock, Jan B Vermorken, Shao Hui Huang (Eds). Published 2015 John Wiley & Sons.

14. Denny L, T Wright. Global Library of Women’s Medicine. Chapters updated. 2016.

15. Oxford Textbook of Obstetrics and Gynaecology. 2016. L Denny: Section Editor: Gynaecological Oncology L Denny, R Sankaranarayan Cancer screening and prevention in gynaecology Article Screening: W Prendiville: Premalignant and malignant disease of the cervix F Amant: Cancer of the uterine corpus J Lederman: Ovarian cancer, Fallopian tube and Peritoneum LJ Rogers: Malignant disease of the vulva and vagina H Ngan, K Chan, S-F Ngu: Gestational trophoblastic tumour A Oza: Chemotherapy and Biological, targeted and immune therapies A Fyles: Radiation therapy in the management of gynaecologic cancer J Cain, S Kibel: Palliative care in obstetrics and gynaecology J Prat: Gynaecological Pathology

MH Botha: Cancer in Pregnancy NH Mbatani, D Richards: Uterine cancer

16. Lynette Denny. Chapter 25: Human Papillomavirus associated Cancers other than Cervical Cancer 3rd Edition ESGO Textbook. Published 2016.

17. Lynette Denny. Section Editor: Current Obstetrics and Gynaecology Reports, Vol 5, Issue 3. Published July 2016 Springer. LA Denny Epidemiology and Burden of Disease Associated with HPV Infection

Jo-Ann S Passmore, Anna-Lise Williamson. Host Immune Responses Associated with Clearance or Persistence of Human Papillomavirus Infections.

Rakiya Saidu. Management of HPV and Associated Cervical Lesions

Tracey S Adams, Nomonde H Mbatani, Linda J Rogers Management of Women with Field Effect of Anogenital Human Papillomavirus Infection.

Julia M L Brotherton, Patrick L F Zuber, Paul L N Bloem Primary Prevention of HPV through Vaccination: Update on the Current Global Status.

EDITORIALS: PEER REVIEWED INTERNATIONAL 1. Nevin J, Denny LA, Soeters R, Dehaeck K, Bloch B Ultrasonography of pelvic masses. Br J Obstet Gynaecol 1998; 105: 137-9

2. Denny L. Guest Editor: Best Practice & Research Clinical Obstetrics and Gynaecology. Preface: Screening for Gynaecological Cancers Best Practice & Research Clinical Obstetrics & Gynaecology 2012;26: 161

3. Denny L. FIGO Cancer Report.

Editorial: Denny L, Quinn M, Hacker N. International Journal of Gynecol Obstet 2012;118: S1

4. Denny L and Kim J. Commentary on article entitled ‘de Kok IM, van Rosmalen J, Dillner J, Arbyn M, Sasieni P, Iftner T, van Ballegooijen M. Primary screening for human papillomavirus compared with cytology screening for cervical cancer in European settings: cost-effectiveness analysis based on a Dutch microsimulation model

Evidence Based Nursing 2012 Mar 5;344: e670

5. L Denny, M Quinn. FIGO Cancer Report 2015 Int J Gynecol Obstet 2015; 131:S75.

6. LA Denny. Questions we should be asking about Bevacizumab for Cervical Cancer Editorial: Liu E, Cripe J, Tewari KS. Anti-Angiogenesis Therapy in Gynecologic Malignancies. Oncology 2015; 282-294

EDITORIALS: PEER REVIEWED LOCAL

1. Bloch B, Nevin J, Dehaeck K, Soeters R, Denny LA (1994) Cancer of the cervix - death by neglect. S Afr Med J; 84: 318-9

2. Soeters R, Denny LA, Nevin J, Dehaeck K, Bloch B (1995) Lletz look before we leep. S Afr Med J; 85(1): 3-4

3. Nevin J, Denny LA, Dehaeck K, Soeters R, Bloch B

Prophylactic oophorectomy at the time of hysterectomy. S Afr Med J 1997; 87(6): 791-2

LETTERS TO EDITOR

1. Anthony J, Coetzee EJ, Kent AP, van der Spuy, Denny LA, Stewart CJ, de Jong PR, van Coeverden de Groot HA HIV in pregnancy – a policy needed. S Afr Med J; 1995; 85(9): 936

2. Dehaeck K, Denny LA, Thomas C, Dommisse J, Anthony J, Nevin J, et al. Patient sedation for routine genital examination. S Afr Med J; 1996; 86(8): 973

3. Whittaker J, Cruse P, Denny LA, Dehaeck K, Soeters R, Duffield M, Bloch B, Wranz P, MacCallum S PAPNET automated screening. S Afr Med J 1996; 86(3): 273-4

4. Dehaeck K, Soeters R, Denny LA, Nevin J Pelvic endometriosis associated with a very high level of CA125. S Afr Med J 1997; 87: 822-4

5. Nevin J, Denny LA, Dehaeck K, van Wijk L, Keating P, Soeters R Hormone Replacement Therapy. S Afr Med J 1997; 87: 1552.

6. Bloch B, Denny LA, Nevin J, Dehaeck K, Whittaker J, Soeters R (1997) Cytological screening for cervical cancer – what are its opportunity costs? S Afr Med J; 87(5): 615

7. Wright TC, Kuhn L, Denny L Reply to Letter entitled: Human Papillomavirus Detection to Screen for Cervical Cancer. Moselhi M. JAMA 2000; 284: 39 – 40

8. Goldie SJ, Kuhn L, Denny L, Wright TC (2001) Cervical cancer screening in Developing countries – Reply JAMA 2001; 286(24): 3080–81

9. Wright TC, Kuhn L, Denny L (2004) Direct visual inspection for cervical cancer screening – Author Reply Cancer 2004; 101(10); 2366–66

10. Landon Myer, Louise Kuhn, Lynette Denny and Thomas C Wright Jr. (2006) Recurrence of Symptomatic Bacterial Vaginosis 12 months after oral metronidazole therapy in HIV-positive and –negative women. J Inf Dis 2006;194: 1797–1799

11. Lynette Denny, Nomonde Mbatani, Tracey Adams, Leon van Wijk, Catherine Behrens, Thanh Tam, Thomas Wright Jr, and Mark Stoler (2016) Performance of an HPV Test in Samples From Women with Histopathologically Confirmed Invasive Cervical Cancer – Author Reply J Lower Genital Tract Disease 2016;20:1

14 SCIENTIFIC PRESENTATIONS AT CONGRESSES

INTERNATIONAL PRESENTATIONS

A. Keynote Lectures

1. Denny L Cervical cancer prevention in the developing world ‘President’s Panel’ of Sixth Biennial Congress of the International Gynaecology Cancer Society (IGCS), Fukuoka, Japan October 1997

2. Denny L ‘Cervical cancer screening in the developing world’. UICC Third African Congress, Copes Conference, Windhoek, Namibia October 1997

3. Denny L, Kuhn L, Wright TC Cervical Cancer Screening. International Scientific Meeting of Royal College of Obstetricians and Gynaecologists, Cape Town South Africa. October 1999

4. Denny L How should we be screening in developing Countries? Annual Scientific Meeting of the British Society for Colposcopy and Cervical Pathology. Manchester, UK April 10 – 12th, 2003

5. Denny L Cervical Cancer – a Paradigm Shift 4th International Conference on Cervical Cancer. University of Texas, MD Anderson Cancer Center May 2005

6. Denny Lynette Opening Keynote Address Preventing cervical cancer in developing countries 57th Conference of German Society of Obstetrics & Gynaecology 16 – 19th September, 2008, Hamburg, Germany.

7. Denny L Is prevention of Cervical cancer possible in developing countries XIX FIGO World Congress of Obstetrics and Gynaecology, 4 – 9th October 2009

8. Denny L Screening in low resource settings AOGIN (Asia Oceania research organization on Genital Infections and Neoplasia) 4th Biennial Conference, March 26 – 28, 2010, New Delhi, India. Invited presentation: Precongress workshop on Cytology and HPV testing

9. Denny L 33rd Annual meeting of the International Association of Cancer Registries (IACR), Mauritius, October 11 – 13, 2011 Invited Keynote Speaker: Women and Cancer in Developing Countries. (Due to illness this presentation was not given)

10. Denny L International Papillomavirus Conference, Berlin, September 17, 2011 Invited keynote speaker Cervical cancer prevention and treatment in Sub-Saharan Africa (Due to illness this presentation was not given)

11. Denny L ANZGOG/ASGO 2014 Combined Scientific Meeting, Canberra, 26-30 March, 2014 Keynote Speaker: Research in gynaecological cancers – a global perspective Inequities in care and its impact on cancer control

12. Denny L Royal Hospital for Women, Sydney, Australia, 3 April 2014 Keynote Speaker: Cancer in Africa – the Challenges

13. Denny L 4th Lebanese Gynecologic Oncologic Group Annual Meeting, Beirut, Lebanon, 19-20 April 2016 Prophylactic HPV Vaccines: Old and new Therapeutic Vaccines: Ready for Prime Time?

14. Denny L International Agency for Research on Cancer (IARC), Lyon, 8-10 June 2016 Screening and early detection of cervical cancer in Africa

B. Plenary Lectures

1. Denny L , Wright TC, Kuhn L, Risi L, Richard R, Pollack A, Lorincz A, Kosteki F Cervical Cancer Prevention in low-resource settings – An evaluation of alternatives. Regional Meeting on Cervical Cancer Prevention and Control for East & Southern Africa, Nairobi, Kenya March 1998

2. Denny L , Kuhn L, Wright TC An International Panel Discussion: Cytopathology in the 21st Century Papanicolaou Society of Cytopathology, Companion Society of the International Academy of Pathology, San Francisco, USA. March 1999

3. Denny L Management Options for Women with ASCUS cytology VII International symposium of the Brazilian Society of Lower Genital Tract Pathology and Colposcopy

4. Denny L HPV DNA testing as a Primary Screening Test, with particular reference to Self-Sampling VII International Symposium of the Brazilian Society of Lower Genital Tract Pathology and Colposcopy October 2000 (Member of International Faculty)

5. Denny L, Kuhn L, Pollack A, Wright TC Prospects for Cervical Cancer Prevention in Developing Countries. XVI FIGO World Congress of Gynaecology and Obstetrics, Washington, DC, USA September 2000

6. Denny L Setting up a Screening Study in Low Resource Settings 19th International Humanpapillomavirus Conference, September 1 – 7, Florianopolis, Brazil

September 2001

7. Denny L The Pap smear: An important but not so perfect method of screening 10th Annual Conference of the Association of Gynaecological Oncologists of India, Kolkata, December 2001

8. Denny L Organising Cervical Cancer Screening Programmes in Low Resource Settings: The Challenge Ahead 10th Annual Conference of the Association of Gynaecological Oncologists of India, Kolkata, December 2001

9. Denny L Management of Gynaecological Cancer in Developing Countries 10th Annual Conference of the Association of Gynaecological Oncologists of India, Kolkata December 2001

10. Denny L Cervical Cancer in Developing Countries 4th International Conference on CANCER IN AFRICA: Meeting the Challenges of the 21 st Century, Accra, Ghana October 2003

11. Denny LA, Kuhn L, De Souza M, Pollack A, Wright T

Cervical Cancer Prevention - a paradigm shift? 8th International Conference on Malignancies in AIDS and Other Immunodeficiencies: Basic, Epidemiologic and Clinical Research. April 29 – 30, Bethesda, Maryland April 2004

12. Denny LA, Kuhn L, De Souza M, Wright T Randomised trial of screening and treating women for cervical cancer prevention 10th Biennial Meeting of International Gynecologic Cancer Society, October 3 – 7, Edinburgh, Scotland, UK  Member of International Scientific Committee  Chairperson and Organiser of Frontier session called “Cervical cancer in developing countries’ with speakers representing Africa, India and Korea October 2004

13. Lynette Denny Role of HPV DNA testing in countries without established screening programmes XVIII FIGO World Congress of Gynecology and Obstetrics Kuala Lampur, 5 – 10th November, 2008 Chairperson: Session entitled HPV Vaccines

14. Lynette Denny Keynote lecture by invitation of the German Society of Obstetrics & Gynaecology L Denny Cervical cancer prevention in Developing Countries, September 2008, Hamburg

15. 12th Biennial meeting of International Gynecologic Cancer Society – IGCS, Bangkok, Thailand, October 25 – 28th 2008 L Denny: Primary Screening in Cervical Cancer Prevention Co-Chair; Merck sponsored symposium on Making the Choice: Helping protect against disease caused by types HPV 6,11,16 and 18

Human Papillomavirus infection and cervical disease in human immunodeficiency virus- 1 infected women

16. L Denny. Novel Screening Algorithms – Evidence from Randomised Controlled Trials. Opening Plenary: AOGIN India Biennial Conference (Interim) Freedom from Cervical Cancer. 25th & 26th April, 2009, Kolkatta

17. L Denny The epidemiology and burden of disease of HPV in Africa Merck Sponsored Symposium, XIX FIGO World Congress of Obstetrics & Gynaecology, October 4 – 9th October, 2009 Also Chair of the Symposium

18. L Denny AORTIC 2009, Dar es Salaan, November 11-14, 2009. Chair and speaker Alternative Strategies for prevention of cervical cancer

19. L Denny. Preventing cervical cancer in sub-Saharan Africa.

EUROGIN 9th International Multidisciplinary Conference, Monte-Carlo, Monaco, 17 – 20 February 2010

 Member of Program Committee and Faculty

20. L Denny, Jeronimo J Roadmap on cervical cancer prevention strategies. Screening in intermediate and low-resource settings

EUROGIN 9th International Multidisciplinary Conference, Monte-Carlo, Monaco, 17 – 20 February 2010

21. L Denny Management of early stage cervical cancer – Outcomes of surgery and radiotherapy

Can cervical cancer be controlled in the developing world?

AOGIN (Asia Oceania research organization on Genital Infections and Neoplasia) 4th Biennial Conference, New Delhi, India, 26 – 28 March 2010

22. L Denny Cervical cancer prevention in HIV positive women

Women Deliver, 2nd Global Conference Washington, DC, 7 – 9 June 2010

23. Denny L Is Research a luxury in designing functional health systems? International Agency for Research on Cancer (IARC), Lyon, 8-10 June 2016

C. Invited Lectures

Sept 1999 Denny L Kuhn L, Wright TC HPV DNA testing in Developing Countries International Federation of Cervical Pathology and Colposcopy – companion meeting to Seventh Biennial Congress of the International Gynecology Cancer Society, Rome, Italy. September 1999

April 2000 Denny L, L, Pollack A, Wright TC The role of HPV DNA testing in low resource settings 18th World Human Papillomavirus Congress, Barcelona, Spain. April 2000

April 2000 Denny L, Kuhn L, Pollack A, Wright TC. Results of Cape Town Visual Inspection Study 18th World Human Papillomavirus Congress, Barcelona, Spain. April 2000

Oct 2002 Denny L High Technology in Low Resource Settings – What is the Future? 9th Biennial Meeting of the International Gynecologic Cancer Society, October 20 – 24, Seoul Korea  Co-Chair: Symposium on New Diagnostic Methods in Cervical Cancer Screening  Co-Chair: Poster Presentations (2 sessions)  Member International Scientific Committee October 2002

April 2004 Denny LA, Kuhn L, De Souza M, Pollack A, Wright T Cervical Cancer Prevention - a paradigm shift? 8th International Conference on Malignancies in AIDS and Other Immunodeficiencies: Basic, Epidemiologic and Clinical Research. April 29 – 30, Bethesda, Maryland April 2004

May 2005 Denny L Presentation to Grand Rounds MD Anderson Cancer Center: Cervical disease in HIV positive women 4th International Conference on Cervical Cancer, May 19 – 22, 2005. University of Texas, MD Anderson Cancer Center, May 2005

May 2005 Denny L Presentation to Faculty of MD Anderson Cancer Centre: My life as a doctor 4th International Conference on Cervical Cancer, May 19 – 22, 2005. University of Texas, MD Anderson Cancer Center, May 2005

Denny L Sept 2005 ‘ Meet the experts session’ Screening in low resource settings

14th International Meeting of the European Society of Gynaecology Oncology (ESGO), Istanbul, Turkey, September 25 – 29, 2005

Oct 2006 Denny Lynette Preventing Cervical Cancer in developing countries 11th Biennial meeting of International Gynecologic Cancer Society, October 14 – 18th, 2006, Santa Monica, USA Member of Scientific Programme Committee

Nov 2006 Lynette Denny, Leon Van Wijk, Nomonde Mbatani, Bruce Howard, Katrien Dehaeck and Robbert Soeters Management of Cervical Cancer in Developing Countries XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lampur, November 5 – 10, 2006

Nov 2006 Lynette Denny, HYS Ngan Limitations of FIGO staging: Cervical Cancer XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lampur, November 5 – 10, 2006

Nov 2006 Denny L. HPV DNA testing in Countries without screening programmes XVIII FIGO World Congress of Gynecology and Obstetrics, Kuala Lampur, November 5 – 10, 2006

Mar 2007 Denny L. Women’s Health in Developing Countries – what have we learned? Key note address at The Royal Women’s Hospital Health Conference, Melbourne, Australia March 28 – 30, 2007

April 2007 Denny L. The quadrivalent vaccine and eradication of cervical cancer.

Jakharta, Indonesia, April 20 – 21, 2007

May 2007 Denny L. Screening for Cervical Cancer and HPV Vaccination if Developed Countries. University of Leuven, Belgium May 2007

Oct 2007 Denny L. Burden of HPV Associated Disease Denny L. Workshop on HPV Vaccines: Introducing HPV vaccination in Developing Countries – what are the challenges? Denny L. Co-chair on Workshop on Visual Inspection with Acetic Acid in collaboration with International Agency for Research on Cancer (IARC) and World Health Organisation (WHO) 6th International AORTIC Conference, Cape Town, South Africa, October 2007

Nov 2007 4th Dubai International Obs-Gynae & Fertility Conference & Exhibition (DIOFCE 2007), Dubai Denny L. Cervical Cancer Prevention in the Era of Vaccination

Oct 2008 33rd National Congress of the South African Society of Obstetricians and Gynaecologists, 4 – 7 October 2008, Somerset West Cape Town L Denny HPV infection and diseases in the genital tract. Plus Co-Chair of session HPV: A Therapeutic Revolution

May 2009 International Papillomavirus Conference, Malmo 8 – 14th May, 2009, Sweden Louise Kuhn, Lynette Denny, Michelle De Souza, Wei-Yann Tsai,

Thomas Wright. Screen and treat using HPV testing is highly effective among HIV infected women Lynette Denny, Louise Kuhn, Michelle de Souza, Wei-Yann Tsai, Thomas C Wright. Benefits of HPV based screen and treat through 36 months of follow up among South African Women

July 2009 3rd Stop Cervical Cancer in Africa Conference (SCCA), 19 – 21st July, 2009 Denny L HPV and cervical disease in HIV infected women. Denny L. Randomised Trials of new Screening Technologies

October 2009 XIX FIGO World Congress of Gynecology and Obstetrics, October 4 – 9th, Cape Town FIGO committee on Oncology: Staging of Gynecologic Malignancies Co-Chair and Lecture on: L Denny New Staging for Cervical Cancer

International Federation of Colposcopy and Cervical Pathology: Cervical cancer prevention across five continents – Current successes and Future Challenges in Africa

November 2009 7th International Cancer Conference, African Organisation for Research and Training in Cancer

Lynette Denny Clinical Efficacy of Quadrivalent Vaccine: Merck Sponsored Symposium

Chair: Workshop on Palliative care for cancer in Africa Speaker: Lynette Denny Cervical cancer in HIV infected women

Co-Chair: Cancer of the cervix in Africa Co-Chair: Alternative strategies for prevention of cervical cancer in Africa

February 2010 EUROGIN 2010, 9th International Multidisciplinary Congress, Monte Carlo, Monaco, 17 – 20 February 2010. 20 Years of Progress and a Path to the Future.

Lynette Denny Preventing cervical cancer in sub-Saharan Africa in developed and developing world.

March 2010 AOGIN (Asia Oceania research organization on Genital Infections and Neoplasia) 4th Biennial Conference, New Delhi, India, 26 March 2010, Session 11

Chair: Precongress Oncosurgical Video Workshop

June 2010 Women Deliver 2010, Washington DC, June 7-9 2010 Session: Strategies to Address Sexually Transmitted Infections Speaker: Lynette Denny HPV screening strategies in HIV positive populations and the interactions between ARTs and HPV or cervical cancer

Sept 2010 WHO Cervical Cancer Control, Geneva, Switzerland, September 20 – 23 2010

October/ SASOG, Sun City, October 31 – November 3 2010 November 2010 L Denny Are we any wiser after AZTEC? Screening for gynaecologic cancers

March 2011 International Federation of Gynecology and Obstetrics/FIGO Ethics Committee: Current Opinion 2011, Goa, India, 16-20 March 2011 L Denny Is healthcare compromised in low resource settings with “Screen and treat Policy”?

March 2011 National health Laboratory Service: Expert Advisory Group: Multi- Disciplinary meeting on Cervical Cancer Screening and the future role of new technologies in the National Program in South Africa, Johannesburg 23 March 2011 L Denny The role of HPV testing in SA (types of assays) VIA in SA

May 2011 Women Against Cervical Cancer (WACC)/EUROGIN 2011: HPV Associated Diseases and Cancer from Reality now to the Future, Lisbon 8-9 May 2011 L Denny

WACC: Solutions for low income setting EUROGIN: Integrating and implementing screening and vaccination programs for high risk populations in Developing world

May 2011 European School of Abdomino-pelvic surgery in Gynecologic Oncology (ESAGON), Milano,16-20 May 2012 (Video Conference) L Denny HPV Testing in Developing Countries.

May 2011 Sub-Saharan Africa CFAR Conference, Kampala, Uganda, 26-27 May 2011 L Denny Preventing Cervical Cancer in the Midst of the HIV/AIDS Epidemic

June 2011 International Confederation of Midwives (ICM)/International Federation of Gynecology & Obstetrics (FIGO), Durban, 19-23 June 2011 L Denny Role of Midwives in early detection of Gynae Malignancy

December 2011 International Conference African Organisation for Research and Training in Cancer (AORTIC), Cairo, Egypt, December 2011 L Denny, B Hendricks, C Gordon, F Thomas, M Hezareh, K Dobbelaere, D Meric, D Descamps Safety and immunogenicity of the HPV-16/18 ASO4-adjuvanted vaccine in HIV-positive women in South Africa (due to illness this presentation was done by Dr Nomonde Mbatani, University of Cape Town, South Africa)

April 2012 World Health Organization: Comprehensive cervical cancer control: a guide to essential practice. Geneva, 23-27 April 2012 (Invited participant to update the recommendations for the WHO document.)

June 2012 2012 ASCO Annual Meeting Cancer Education, Chicago, Illinois, USA, 1-5 June 2012. Invited Speaker and Chair in Session: Recent Clinical Highlights in Gynecologic Oncology L Denny The International Perspective on the Global Advances in Gynecologic Oncology

July 2012 2012 Conference of Asia Oceania Research Organisation on Genital Infections and Neoplasia (AOGIN), Hong Kong, 13-15 July 2012. Invited Speaker: Session Oncology Surgery Controversies in the management of Vulvar Cancer

Co- Chair: Oncology Surgery Co-Chair: Proffered Papers

QIAGEN’s Symposium, 15 July 2012 (part of AOGIN Conference) L Denny Cost Effectiveness of HPV DNA Screening

October 2012 XX FIGO World Congress of Gynecology and Obstetrics, Rome, Italy, 7-12 October 2012 Invited Speaker: Session Cancer of the Cervix in Africa Surgical management

November 2012 EUROGIN 2013, Florence, Italy, 3-6 November 2012. Denny L, Hendricks B, Herve C, Thomas F, David MP, Struyf F Cell-mediated immune response to the HPV-16/18 AS04-Adjuvanted vaccine in HIV-positive women in South Africa up to 12 months after vaccination

April 2013 2nd International Gynecologic Cancer Society (IGCS), Bali, Indonesia, 11-13 April 2013. Welcome (IGCS President) Presidential lecture Invited Speaker: Palliative Care in Gynecologic Oncology (Multi-Disciplinary Approach)

July 2013 XXVIIIth Australian Society of Gynaecologic Oncology, Darwin, Australia, 3-7 July 2013 Keynote Presentations: Gynae Oncology from a South African perspective Vulvar Cancer

October 2013 1st FIGO Africa Regional Conference of Gynecology, Addis Ababa, Ethiopia, 03-05 October 2013. Invited Speaker: Session Cervical Cancer Prevention Strategies in Africa - Part 1

L Denny Proposed new staging of ovarian, fallopian tube and peritoneal cancer. Is it possible to prevent cervical cancer in Africa? Burden of HPV diseases globally compared to the African region.

October 2013 18th International meeting of the European Society of Gynaecological Oncology (ESGO), Liverpool, UK, 19-22 October 2013. Co-Chair: Cervical Cancer Invited Speaker: Session Future Directions of Gyn Oncology Societies Invited Speaker: Session Glass with the Expert HPV Vaccination in HIV+ Women

December 2013 The 3rd Biennial Meeting Asian Society of Gynecologic Oncology, Kyoto, Japan, 13-15 December 2013 Cancer prevention via HPV vaccination in developing countries Pain management in women with advanced cervical cancer

March 2014 Royal Hospital for Women, Sydney, Australia, 3 April 2014 Grand Rounds: Department Obstetrics and Gynaecology, Division: Gynaecological Oncology Chair: Professor N Hacker

May 2014 IFCPC 15th World Congress for Cervical Pathology and Colposcopy, London, 26-30 May 2014 Why is cervical cancer such a neglected disease in developing countries? Cancer control and prevention in Africa. Co-Chair with Professor W Prendiville: Quality Assurance in Training

November 2014 International Gynecologic Cancer Society (IGCS) and Supportive Care Nursing Symposium, Melbourne, Australia, 8-11 November 2014 Welcome and Symposium Hosted by IGCS President: L Denny Session: The FIGO 2014 Staging of Ovarian, Fallopian Tube and Peritoneal Cancer Chair: L Denny

Session: Gynecological Oncology in Under Reported Countries Chair: L Denny

Round Table: Your Country, Your Treatment: The Have and Have-Nots in Gynecologic Oncology

Moderator: Z Daniel, L Denny, R Barakat, D Cibula, J-H Nam Cancer Care in Resource Restricted Environments – how can those in the Wealthier Nations Help? Why is Cancer not on the Health Agenda of Developing Countries? How about Africa in Gynecological Oncology Training? Developing world perspective on supportive care needs

March 2015 25th Annual International Colloquium, hosted by Texas Children’s Pavilion for Women, Houston, Texas, 9-11 March 2015 LA Denny Cancer in Africa – what are the challenges? Why is cervical cancer and its prevention so neglected in Africa?

March 2015 Society of Gynecologic Oncology (SGO) Latin-America Investigators Symposium – The Future and Potential of Collaborations with Developing Countries, Chicago, 28 - 30 March 2015 Special interest session III: First International Advanced Surgery and Research Symposium: Moderators: L Chuang, LA Denny, L Chiva, P Ramirez LA Denny Cervical Cancer Prevention: Lessons Learned from Africa.

June 2015 MSD Africa Vaccines Summit, Casablanca, 10 – 11 June 2015 LA Denny Disease burden and the rationale for the HPV vaccination inclusion in NIP Epidemiology of HPV, global vs Africa

October 2015 XXI International Federation of Gynecology and Obstetrics (FIGO) World Congress, Vancouver, 4-9 October 2015.

Organiser of Gynaecological Oncology sessions and introducer of Eve Ensler who delivered the Inaugural Mahmoud Fathalla Lecture entitled “In the Body of the World”.

October 2015 19 th International Meeting of the European Society of Gynaecological Oncology (ESGO), Nice, 24 – 27 October 2015 LA Denny Cervical Cancer Screening: a never-ending challenge

November 2015 AORTIC International Cancer Conference, Marrakesh, Morocco, 18 – 22 November 2015 Session: Medical Education in Oncology: The impact of the E learning Methodology in African settings Chair: LA Denny Session: Impact inequity on cancer care Chair: LA Denny Cancer in Africa Bevacizumag extends survival in cervical cancer recurrent, but at what cost?

D. International poster presentations

1. Denny L , Duffield M “Ovarian Tumors of Low Malignant potential (LMP). Clinicopathologic review and flow cytometric analysis of DNA ploidy status” Fifth Biennial Congress of International Gynaecology Cancer Society (IGCS). Philadelphia, USA. September 1995

2. Roland ME, Myer L, Chuunga R, Martin L, Maw A, Coates T, Denny L A Prospective Study of Post-exposure Prophylaxis Following Sexual Assault in South Africa 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA In: Abstracts of the Poster presentation 2005

3. S Walraven, L Myers, B Allan, A Williamson, L Denny Management of Cervical Disease in HIV-1 positive women. 22nd International Papillomavirus Conference and Clinical Workshop April 2005

4. S Walraven, L Myers, B Allan, A Williamson, L Denny Management of Cervical Disease in HIV-1 positive women.  Oral presentation given by Professor Williamson 22nd International Papillomavirus Conference and Clinical Workshop April 2005

5. H Kitchener, I Heard, H Cubie, C Bradbeer, L Denny, P Sasieni et al. International Cohort Study of Cervical Pathology in HIV-1 infected women: Baseline Data and the MACH-1 Study Group 22nd International Papillomavirus Conference and Clinical Workshop April 2005

6. L Denny , S Walraven, L Myers, B Allan, A Williamson. HPV infection in untreated HIV-1 infected women in Cape Town, South Africa. 22nd International Papillomavirus Conference and Clinical Workshop April 2005

7. S Walraven, L Myers, B Allan, A Williamson, L Denny

Management of abnormal cytology in HIV-1 positive women 22nd International Papillomavirus Conference and Clinical Workshop April 2005

8. R Sun, J Kornegay, L Denny, S Taylor, L Kuhn, T Wright Determination of an analytic cutoff for the Amplicor HPV test for detecting prevalent high-grade cervical disease 22nd International Papillomavirus Conference and Clinical Workshop April 2005

9. J Goldhaber-Fiebert, L Denny, M De Souza, T C Wright, L Kuhn, S Goldie The Effectiveness and Costs of Reducing Loss to Follow-Up in a South African Cervical Cancer Screening Study 27th Annual Meeting of the Society for Medical Decision Making, San Francisco, CA Feb 2006

10. J Goldhaber-Fiebert, L Denny, M De Souza, TC Wright, L Kuhn, S Goldie The Effectiveness and Costs of Reducing Loss to Follow-Up in a South African Cervical Cancer Screening Study International Papillomavirus Conference, Vancouver, BC, 2005 April 2005

11 A Tergas, R Saidu, R Boa, J Moodley, T Wright, S Campbell, C Svanholm-Barrie, D Persing, L Kuhn, L Denny Attitudes and acceptance of self-sampling for HPV testing: A qualitative study in Cape Town, South Africa 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal October 2016

LOCAL PRESENTATIONS

1. Denny L Prospects for Cervical Cancer Prevention in Developing Countries Sixth Reproductive Health Priorities Conference, Cape Town August 2000 2. Denny L Rape in South Africa – what have we learned? 8th Reproductive Health Priorities Conference 2002 October 2002 3. Denny L A Women’s Health 12th National Family Practitioners Conference, Stellenbosch, South Africa August 2003 4. Denny L Management of the terminally ill patient South African Society of Obstetricians & Gynaecologists (SASOG) Fifth Gynaecology Oncology Congress, Cape Town, South Africa. March 1994

5. Denny L New techniques for cervical cancer screening Seventh South African Gynaecological Oncology Society Congress, Mpumalanga, May 1 – 3 May 2001

6. Denny L Care of the Terminally Ill Patient

Seventh South African Gynaecological Oncology Society Congress, Mpumalanga, May 1 – 3 May 2001

7. Denny L Challenges in the use of PEP post – rape First South African Gender-Based Violence and Health Conference, Johannesburg April 2002

8. Denny L., Martin L, Buford L, Van Der Merwe L. Evaluation of a standardised sexual assault protocol First South African Gender-Based Violence and Health Conference, Johannesburg April 2002

9. Denny L, Martin L, Buford L, Van Der Merwe L. Evaluation of a Standardised Sexual Assault Protocol and the Epidemiology of Rape Survivors in Cape Town Ninth Interdisciplinary Symposium, Violence and Trauma and the Health of the Nation. The Colleges of Medicine of SA, Rondebosch, May 2002

10. Denny L, Duffield M. Aspects of a review of 82 Borderline Tumours of the Ovary treated at GSH between 1970 and 1990 SASOG Congress, Bophututswana, South Africa. August 1994

11. Denny L Imaging in Gynaecological Cancer Oncology Imaging: An Integrated, Multidisciplinary Approach. 30 August – 1 September, Cape Town September 2002

12. Denny L Post exposure prophylaxis for prevention HIV transmission in survivors of rape Western Cape Networking Aids Community of South Africa HIV Summit December 2002

13. Denny L UCT Department of Obstetrics and Gynaecology Postgraduate Refresher Course, Cape Town, South Africa, 24-26 November 2011 Human Papilloma virus – whats new? November 2011

14. Denny L South African Society of Obstetricians & Gynaecologists (SASOG), Drakensberg, 6-10 May 2012 (Margaret Orford Lecture) Is it possible to control cancer of the cervix in Africa?

15. Denny L World Cancer Leaders’ Summit, Cape Town, South Africa, 18-19 November 2013.

16. Denny L The African Organisation for Research and Training in Cancer (AORTIC): 9th International Cancer Conference “Cancer in Africa: Bridging Science and Humanity”, Durban, South Africa, 21-24 November 2013 Cancer in Africa Training human resources in the context of national roll-out of cervical screening State of Medical Education in Africa Public private partnerships

17. Denny L UCT Department of Obstetrics and Gynaecology Postgraduate Refresher Course, Cape Town, South Africa, 28-30 November 2013 Current approaches to cervical cancer screening

The importance of introducing an HPV Vaccine in South Africa HPV DNA testing Workshop: Colposcopy Masterclass

18. Denny L 3rd Regional IGCS Meeting, Cape Town, South Africa, 16-18 May 2014 Presidential Address: Cervical Cancer in Africa – is there hope?

19. Denny L 36th South African Society of Obstetricians & Gynaecologists (SASOG) Congress 2014, Cape Town, South Africa, 18-21 May 2014 Will HPV vaccination work in South Africa?

20. Denny L

South African Medical Association Conference, Durban, Kwazulu-Natal, 29-31 August 2014 Cervical cancer prevention strategies in Africa: the SA perspective.

21. Denny L

SA HPV Advisory Board Meeting and Roche HPV Master Class, La Dolce Vita, Hartbeespoort Dam, 27-29 May 2015 Cervical Cancer in South Africa/Africa

22. Denny L CANSA Research in Action Conference, Stellenbosch, 14-15 July 2015 Why is cervical cancer such a neglected disease in Africa

23. Denny L Midwifery & Birth Conference, Cape Town, 30-31 October 2015 Opening Speaker: The importance of midwives today.

24. Denny L UCT Department of Obstetrics and Gynaecology Refresher Course, Cape Town, 26-28 November 2015 Cutting edge advances in Gynae oncology

RESEARCH AND OTHER GRANTS

PROJECT: FUNDING AMOUNT:

Khayelitsha Cervical Cancer Screening US$ 750,000 Project (January 1996 – per annum December 2006)

Principal investigators Professor Lynette Denny (UCT) Professor Louise Kuhn (Division Epidemiology and Biostatistics, Columbia University, New York, New York) A/Professor Thomas C. Wright (Head: Division Gynecologic Pathology, Department of Pathology, Columbia University, New York, New York)

Funding The study was funded principally by EngenderHealth (a New York-based non- governmental organisation involved in Reproductive Health) and the Bill and Melinda Gates Foundation through the Alliance for Cervical Cancer Prevention (ACCP). Funding US$750 000 per year and which ended December 2006 when the project was completed.

Evaluation of alternative strategies for the prevention of cervical cancer

Post Exposure Prophylaxis in the context of sexual assault in South Africa (January 2004 – August 2005) R 1.3 million per annum

Principal Investigators: Professor Lynette Denny, Dr Michelle Roland Co-investigators: Professor Lorna Martin, Dr Roy Chuunga, Professor Thomas Coates, Ms Sia Maw

Funding Funding from University of California, San Francisco, USA

Management of Abnormal Cytology in HIV-1 Positive Women (MACH- R 1.2 million 1) per annum plus £30 000 Principal Investigators: Professor Lynette Denny and the MACH-1 group led by Professor Henry Kitchener, Academic Head, Department Obstetrics & Gynaecology, Manchester University, Manchester, UK

Co-investigators: Dr Landon Myers, Mr Bruce Allan, Dr Ros Boa, Professor Anna-Lise Williamson (all of University of Cape Town)

Funding Funding has been from Parthenon Trust (£30 000) and Secure the Future (Trust fund of Bristol-Myers Squibb) for R1.2 million. Project ongoing and is funded by general research funds.

Graham Beck: Personal endowment for ongoing research into R2.5 million cervical cancer prevention April 1 2006 - 2007

Randomised double blind trial of bivalent HPV vaccine in HIV positive R 16 million women aged 18 – 25 years, sponsored by GlaxoSmithKline, commenced January 2008 – Completed December 2011

Female Genital Warts Study Principal Investigators: S Tayib, L Denny

Prospective study of 150 women with genital warts who presented to Colposcopy Clinic at Groote Schuur Hospital – all women underwent HPV DNA typing, HIV testing and testing for lower genital tract intraepithelial neoplasia (Merck Investigator Led Research Award) Completed 2012 R 600 000

Increasing specificity of HPV DNA testing in South African Women project, 1 February 2015 - 31 December 2016. National Cancer Institute grant R3 million

SA Medical Research Council award for a Cancer Research Centre titled “MRC/UCT Gynaecological Cancer Research Centre” R3 million March 2015 – 2019

OTHER RESEARCH PROJECTS

Khayelitsha Cervical Cancer Screening Project (KCCSP)

Principal Investigators: Lynette Denny, Thomas Wright, Louise Kuhn

Young Women’s Study

This study recruited 3000 HIV negative women aged 18 – 34 years of age. In this cross-sectional study we performed cytology and HPV DNA testing in order to evaluate a] the prevalence of high-risk HPV infection in young women (we already have these data on women aged 35 – 65 years) in this community and b] the types of HPV among HPV positive women.

HIV intervention sub-study (HISS): Inclusion of voluntary HIV counselling and testing services as part of a cervical cancer screening project

This sub study was designed to evaluate the impact of intensive one-on-one counselling on the uptake of HIV testing and on behavioural changes in women recruited to the study.

Other aspects of cervical cancer screening being studied in the Khayelitsha project include:

 Evaluation of the barriers to screening and the factors that facilitate compliance with a screening programme  Referral patterns of women enrolled in a screening programme  Horizontal versus vertical integration of cervical screening programmes at primary care level  A cost-benefit analysis has been conducted, using mathematical modelling and assumptions based on the performance characteristics of the four different screening tests. This is being performed by Dr Susan Goldie, Harvard School of Public Health, Boston, USA in

collaboration with the principal investigators. The manuscript of this work is published (see references)  Hidden costs of Screening e.g. costs associated with tracking defaulters, treating associated co-morbid conditions. This work is in progress and is being conducted through Dr Goldie’s research fellow who has spent time (August/September 2004) embedded in the project.  Comparison of conventional versus liquid-based cytology has been incorporated as into the study design of Phase 3 of the Khayelitsha study and is now published (see references)  HPV DNA typing by PCR (polymerase chain reaction) of all HPV DNA positive women identified in all three phases of the study (see references).

Evaluation of the AMPLICOR Human Papilloma Virus (HPV) Test for the Detection of High Risk Human Papillomavirus in Cervical Samples collected in Preservcyt solution and Surepath Media Principal Investigator: Professor Lynette Denny Co- investigators: Dr Rosalind Boa, Ms Ayesha Sasman (University of Cape Town) This study was funded by Roche Molecular Systems and the Cape Town site was asked to contribute 600 cases to a trial involving an additional 21 000 women recruited from sites in the USA. The data collected from this trial was used for an FDA application for the registration of the AMPLICOR test for HPV DNA testing in the USA. The study recruited 600 women attending the Groote Schuur Hospital colposcopy clinic with abnormal cervical cytology. All women who gave consent had a specimen taken from the cervix for later testing with AMPLICOR as well as routine colposcopy and histology. The women will be followed for a period of 7 years thereafter. The study is complete.

African Women with Cervical Cancer (AWACC) Study: Principal Investigator: Professor Lynette Denny Co-investigator: Dr Rosalind Boa

This study recruited 567 women with invasive cervical cancer from Nigeria, Ghana and South Funded by GlaxoSmithKline. All biopsy specimens were typed for HPV at a central laboratory. The data was published in the International Journal of Cancer in 2014 (Int J Cancer 2014;134:1389-98).

Title: Evaluation of the safety and immunogenicity of GlaxoSmithKline Biologicals’ HPV Vaccine 580299 in adult Human immunodeficiency virus infected female subjects.

Detailed Title: A phase I/II, partially-blind, randomized, controlled study to assess the safety and immunogenicity of GlaxoSmithKline Biologicals’ HPV-16/18 L1 VLP AS04 vaccine administered intramuscularly according to a three-dose schedule (0,1,6-month) in human immunodeficiency virus (HIV)-infected female subjects aged 18-25years.

Principal Investigator: Professor Lynette Denny Co – investigators: Dr Michelle De Souza, Dr Rosalind Boa, Dr Bronwyn Hendricks

This was the first study of the safety and immunogenicity of the HPV vaccine against types 16 and 18 performed in HIV Positive women. The study recruited 30 HIV negative women (all of whom were vaccinated) and 120 HIV positive women in WHO stage 1 disease. These women were randomised to receive vaccine or placebo (60 in each arm). Women were followed for 18 months to evaluate safety and immunogenicity. Trial completed December 2011 and manuscript published in Vaccine 2013;31(48):5745-53

Phenotypic and Functional Characterization of Cervical and Peripheral HIV-specific T cell Responses Principal Investigator: Dr Jo-Ann Passmore (University of Cape Town) Co-Investigators: Dr Wendy Burgers, Professor Lynette Denny, Dr Carolyn Williamson and Dr Clive Gray The major objective of this study was to characterise HIV-specific cervical immune responses and to determine if compartmentalization occurs in chronic HIV infection by comparing the phenotypic and functional characteristics of T cells at the cervix to those in peripheral blood. Samples for this study were obtained from women enrolled in my cohort study of HIV-1 positive women described above and the data have been published

Cervical immune response patterns to human papillomavirus in women with HPV-associated squamous intraepithelial lesions Principal Investigator: Professor Anna-Lise Williamson (University of Cape Town) and National Health Laboratory Service (NHLS) and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Co-investigators: Dr Jo-Ann Passmore, Dr Diane Marais, Professor Lynette Denny, Dr Robbert Soeters, Dr Nomonde Mbatani. The aim of this study was to investigate cellular and humoral immune responses involved in genital HPV infections, with particular emphasis on the immune deviations associated with severity of HPV-associated disease. This was achieved by investigating local factors (cytokines and antibodies) involved in cervical immunity in women with SIL and compared these to responses at corresponding systemic and oral sites. The study involved HPV typing, viral load

67 | P a g e CVSEPTEMBER2016 determination, single cell cytokine analysis and HPV-specific antibody detection in cervical, oral and peripheral specimens.

Molecular profiling and characterisation of genes involved in the development of cervical cancer.

Principal Investigator: Dr Virna Leaner (University of Cape Town)

Co-investigators: Ms Pauline Forrester, Michelle Maritz, Professor Iqbal Parker, Dr Michael Birrer, Professor Lynette Denny, Dr Nomonde Mbatani, Professor Dhiren Govender, Dr Maureen Duffield, Dr Christopher Maske

A comprehensive analysis of the molecular changes occurring during the development of cervical carcinoma may have a significant impact on our understanding and treatment of the disease. To address the underlying molecular events related to cervical cancer our specific aims are: (a) to identify transcriptional profiles and genes associated with the progression of disease (use microarray analysis to identify profiles and genes) and (b) to characterize genes as potential markers, and genes that have functional significance in the development of the cancer (quantitative RT-PCR and immunohistochemisty to confirm microarray data and RNA technology for functional studies).

The prognostic significance of tumour infiltrating immune cells in Vulvar Cancer and the immunology of Vulvar Intraepithelial Neoplasia (VIN) in the context of HIV infection. Principal Investigator: Professor LA Denny Co-investigators: Dr Rakiya Saidu (PhD student), Dr Jo-Ann Passmore, Dr Linda Rogers

A study investigating the prevalence and types of HPV infections associated with vulva cancer and VIN in women and to determine whether defects in phenotype and/or function of tumour- infiltrating immune cells within the tumour correlate with prognosis in vulvar cancer.

Is there a difference among women of African heritage compared to women of European or mixed race in terms of the genetic profile in women diagnosed with ovarian cancer Principal Investigator: Professor LA Denny Co-investigator: Dr Tracey Adams (PhD student) Study to determine whether there are biological and genetic differences in women afflicted with ovarian cancer according to ethnicity

Vulva stem cell treatment for lichen schlerosus Principal investigator: Professor LA Denny Co-investigator: Dr Bothwell Guzha

This is a prospective randomised controlled study using a novel surgical approach. The study will compare the response to treatment in women with anogenital lichen sclerosus treated with a vulval infection of adipose-derived mesenchymal cells and platelet rich plasma or topical clobetasol.

A cross-sectional, combined methods study: women diagnosed with invasive cervical cancer presenting to Groote Schuur Hospital Principal investigator: Professor LA Denny Co-investigators: Dr Nwabisa Giyose (MPhil student), Dr Tracey Adams

Women diagnosed with advanced cervical cancer (stage IIB – IVB) will be investigated at the Combined Assessment Clinic (CAC) at Groote Schuur Hospital. This is a prospective descriptive study, using a combined methods approach, which will measure both quantitative and qualitative data.

INTERNATIONAL RESEARCH COLLABORATIONS

 A/Professor Thomas Wright: Department of Pathology, Division of Gynecologic Pathology, Columbia University, New York, New York

 Professor Louise Kuhn: Division of Epidemiology and Biostatistics, Columbia University, New York, New York

 Alliance for Prevention of Cervical Cancer: The Alliance consists of five organisations working in cervical cancer prevention in different parts of the world. The Alliance was awarded $50 million by the Bill and Melinda Gates Foundation in 1999 to be divided equally among the five organisations. The organisations involved include (ongoing):

o EngenderHealth (New York based non-profit organisation) o JHPIEGO (John Hopkins School of Public Health) o PAHO (Pan-American Health Organisation) o IARC (International Agency for Research into Cancer) o PATH (Program for Appropriate Technology in Health)

 Department of Obstetrics & Gynaecology, University of Manchester, Manchester, UK. Main collaborator Professor Henry Kitchener, Academic Head of Department, Department Obstetrics & Gynaecology, Manchester University.

This study involved collaborators from 9 other European centres in France, Scotland, Poland, Spain, Italy, Ireland and England.

 A/Professor Michelle Roland, Physician, University of San Francisco, California.

Adherence and compliance to anti-retroviral post-exposure prophylaxis after Rape.

 SA MRC Gynaecological Cancer Research Centre – a coalition of 12 basic science and clinical researchers focussed on gynaecological cancer and funded by the Medical Research Council of South Africa.

 Collaboration with Columbia University, National Cancer Institute of National Institute of Health and Cepheid. This study aims to improve the specificity and human papilloma virus Screen-and-Treat in South Africa. This collaborative study utilizes a new point-of-care test developed by Cepheid.

TEACHING, TRAINING AND EDUCATION

Undergraduate Lectures/Tutorials

Convenor Old Curriculum Fifth year gynaecology teaching programme 1996 to 2004

 Course co-ordinator and designer  Supervision of monthly examination  Weekly small group tutorials  Supervision of Projects

New initiatives taken in convening this course involved introducing broader concepts of Women’s Health. These include organising and introducing lectures/seminars on:  Understanding Gender (African Gender Institute, University of Cape Town)  Two hour seminar on Adolescent Sexuality and Contraception (Planned Parenthood Association of SA)  Two hour seminar on Adult Sexuality (Dr Eve Wasserman)  Two hour seminar on Rape (Rape Crisis Cape Town)  Two hour seminar on Domestic Violence (NICRO)  The Forensic Examination of Women who are Raped (Professor L Martin/ Dr Sonata Walraven)

At the end of each block the students underwent an examination consisting of an OSCE and a one and a half hour written examination. One of the OSCE stations was devoted to feed-back from the students regarding the course and this information was invaluable in the constant adjustment of the programme.

In addition to the examination, the students were required to perform a literature review on any subject related to Women’s Health. This was performed in groups. One such project, on Female Genital Mutilation, was published by the SAMJ in 1999.

Other responsibilities included supervising problem students, including providing extra tuition and practice for written examinations, particularly for students writing in English as a second language.

Design Of New Curricula For Semesters 6, 7/8 And 9/10 MBChB

Principle designer of the gynaecology blocks in semesters 6, 7/8 and 9/10 in 2004. The timetables and objectives of these courses are available on request. The three different courses

71 | P a g e CVSEPTEMBER2016 occurring during the 3rd, 4th and 5th years of the MBChB programmes were designed to build depth and breadth of knowledge and experience over time. These courses have been taken over by other convenors subsequent to my initial design.

Editor Student Lecture Notes Editor and contributor to Gynaecological Lecture Notes prepared by the Department of Obstetrics & Gynaecology for the students. Upgraded January 2005 and currently undergo revision (2012)

Clinical Teaching

Clinical teaching includes daily teaching ward rounds, pre-operative rounds, post-operative rounds, working ward rounds and formal grand teaching rounds. All 5 clinics are attended by students on a daily basis.

Post-Graduate Teaching

Supervision of training of Gynaecology Oncology Senior Registrar/Sub-specialist

The Gynaecology Oncology Unit of the Department of Obstetrics & Gynaecology was recognised for sub-speciality training by the Royal College of Obstetrics & Gynaecology until 2000. It was recognised as a sub-speciality training unit by the Health Professionals Council of South Africa in 2007. The training programme is 2 years and only registrars who have obtained Part 2 specialist exams are eligible. Gynaecological Oncology has been recognised as a sub- speciality of Obstetrics and Gynaecology by the Health Professionals Council of South Africa and we have been registered as a sub-speciality training unit since 2007. We have two training numbers as of January 2010.

Supervision of the senior registrar entails teaching/training in general gynaecological and cancer surgery, management of all gynaecological cancers and complications, colposcopy, chemotherapy, radiation therapy, gynaecological pathology, management of terminally ill patients including provision of support to family. Training also includes management of the ward, providing a consultative service to other wards and hospitals, clinics and students. An important aspect of the supervision of the senior registrar is teaching a multi-disciplinary approach to cancer management.

In addition, the fellow is required to undertake a research project and to write this up for a MMed dissertation and to pass an exit examination.

Clinical teaching

Teaching of post-graduate registrars takes place at the bedside on ward rounds, in clinics (5 per week) and in the operating theatre. A daily teaching ward round which is attended by registrars, interns, students and nurses.

Monthly Tutorials on Variety of Subjects in Obstetrics & Gynaecology to Part I and Part II Registrars

Forensic and Clinical Management of Rape

Three monthly training of gynaecology registrars at Groote Schuur Hospital and medical officers at G F Jooste Hospital from 1999 – 2006.

External Examination at Undergraduate Level

External Examiner for the M.B., B.S. Final Summative Examination in Obstetrics & Gynaecology held November 2005, Hong Kong University, Hong Kong.

External Examiner for MBChB final Obstetrics & Gynaecology examination, University of KwaZulu Natal 2009, 2010, 2012, 2016

External Examiner for MBBS III and V, University of Botswana, 2015

External Examination Of Theses and Post – Graduate Examinations

Post-graduate Examinations

Overseas Examiner in Obstetrics & Gynaecology - Clinical Examination of the 2005 Licensing Examination of the Medical Council of Hong Kong, November 2005, Hong Kong University, Hong Kong.

Part I FCOG (College of Medicine of SA) examiner 1998, 1999, 2000, 2002, 2003, 2004, 2005

Part II FCOG (College of Medicine of SA) examiner 2007, 2008, 2009, 2010, 2012, 2014, 2015, 2016 Obstetrics & Gynaecology specialist examination

Convenor and Examiner of Gynaecology Oncology sub-speciality examination of College of Medicine of SA, October 2009.

Convenor and Part II Examiner of College of Medicine of SA, 2015 Obstetrics & Gynaecology specialist examination

Moderator Part II College of Medicine of SA, 2016 Obstetrics & Gynaecology specialist examination.

Theses Examined

1. Professor Lorna Martin

MMed (Forensic Pathology), University of Cape Town Title: Epidemiology of Rape and Rape Homicide. 1999

2. Dr Nazeema Abrahams

MPhil (Public Health), University of Western Cape Title: Protocol for Study of Domestic Violence in Cape Town. 1998 (completed and graduated)

3. Dr Nazeema Abrahams

PhD (Public Health), University of Cape Town Title: Men’s use of violence against intimate partners: A study of working men in Cape Town. 2002 (completed and graduated)

4. Dr DB Truter

MMed (O&G) Title: Predictive factors for incomplete excision margins after large loop excision of the transformation zone (LLETZ) August 2009

5. Dr TP Motloung

MPH (Public Health), University of Witwatersrand Title: Prevalence of abnormal pap-smear among sex-workers in Hillbrow, Johannesburg, South Africa 2010

6. Dr XBS Pupuma

MMed (O&G) Title: A retrospective review of uterine malignancies amongst women presenting to the Gynaecology Oncology Clinic, IALCH

7. Dr Angelique Colleen Wildschut

PhD Title: A feminist investigation into the reasons for attrition of women doctors from the South African medical profession and practice: exploring the case of UCT medical school between 1996 and 2005 2010

8. Dr S Moosa MMed (O&G): Title: Profile of women presenting with abnormal uterine bleeding to Inkosi Albert Luthuli Central Hospital (IALCH) over a four year period. 2014

9. Dr A Ghani MMed (O&G): Title: Clinical profile of HIV negative and HIV positive women presenting with cervical cancer in Durban 2014

10. Dr C Valashiya MMed (O&G): Title: Audit of Women with abnormal pap smears referred for colposcopy to Port Shepstone Hospital 2015

3.5 Supervision of Theses Completed

1. Dr Simone Honikman

MPhil Thesis: Maternal and Child Health, University of Cape Town Title: Clients returning for cervical screening results – a focus group study exploring the reason why women spontaneously return for their results at the Khayelitsha Cervical Screening Project. 2004: Graduated with distinction

2. Dr Steffi Hinz

MMed Thesis: Department Obstetrics & Gynaecology, University of Cape Town Title: Prognostic factors in women with Stage III b Cervical Cancer. 2002: Graduated

3. Dr Kobus Van Rensburg

MMed Thesis: Department of Obstetrics & Gynaecology, University of Cape Town Title: Comparison of liquid-based cytology with conventional cytology. 2005: Graduated

4. Dr Linda Rogers

MMed Thesis: Department of Obstetrics & Gynaecology, University of Cape Town Title: Chemoradiation of the vulva June 2009: Graduated

5. Dr Ennet Banda Chipungu

MMed Thesis: Department of Obstetrics & Gynaecology, University of Cape Town Title: Cytological and colposcopy follow up of women treated for cervical intraepithelial neoplasia with large Loop excision of the transformation zone at Groote Schuur Hospital, from 2000-2004. 2011

6. MSc Research Report, Dr L Pule Potential prognostic factors for cervical cancer patients undergoing radiotherapy at Charlotte Maxeke Johannesburg Academic Hospital: A retrospective analysis.

3.6 Supervision Of PhD/MPhil Theses

PhD Thesis, Ms Sine Duma

Co-supervisor: Professor J Mekwa, Department of Nursing, University of Cape Town Department of Nursing, University of Cape Town. Title: Women’s Journey of Recovery from Sexual Assault Trauma Degree awarded December 2006

PhD Thesis, Dr Carolyn Tasker

Co-supervisors: Professor Wojnarowska and Mr Mark Charnock, Department of Dermatology, Oxford University, Oxford, UK. Title: The interaction of Environmental and Genetic factors in the development and progression of Vulvar Intraepithelial Neoplasia.

PhD Dissertation, Dr M D Zeier Title: The effect of highly active antiretroviral therapy on Human Papilloma Virus Infection and Cervical Dysplasia in HIV infected South Africa women

PhD Thesis, Dr Tracey A Adams

Title: Is there a difference among women of African heritage compared to women of European or mixed race heritage in terms of the genetic profile in women diagnosed with ovarian cancer. In progress.

PhD Thesis, Dr Rayika Saidu Co-supervisors: Dr J-A Passmore, Division of Virology, UCT, Dr L Rogers, Department of Obstetrics & Gynaecology, UCT and Dr L van Wijk, Department Radiation Oncology, Groote Schuur Hospital.

Title: The prognostic significance of tumour infiltrating immune cells in Vulvar Cancer and the Immunology of Vulvar Intraepithelial Neoplasia (VIN) in the context of HIV infection. In progress.

MPhil (Clinical Epidemiology), Miss T L Karimanzira Title: Knowledge and awareness and attitudes regarding Human Papillomavirus vaccination among college-aged women in Maun, Botswana

MPhil (Gynaecology-Oncology), Dr K Govender Title: The natural history of low grade squamous intra-epithelial lesions (LSIL) in women attending Groote Schuur Hospital Colposcopy Clinic. Degree Awarded December 2015

MPhil (Gynaecology-Oncology), Dr D Richards Co-Supervisor: Dr L van Wijk, Department Radiation Oncology, Groote Schuur Hospital Title: High-risk type endometrial carcinoma. A retrospective review of cases at Groote Schuur Hospital 2004-2008 Degree Awarded December 2015.

MPhil (Gynaecology-Oncology), Dr N Giyose Co-Supervisor: Dr T S Adams, Department of Obstetrics and Gynaecology, Groote Schuur Hospital Title: A cross-sectional combined methods study: Women diagnosed with invasive cancer presenting to Groote Schuur Hospital In progress

Registrar Commentaries Supervised (for Part II of FCOG)

1996 Grundlingh L. Residual preinvasive and invasive disease in hysterectomy specimens of women who underwent prior cone biopsy.

1998 Clark K. Audit of the management of benign gestational disease at Groote Schuur Hospital from 1984 to 1994.

1999 Howard B. Audit of Vulval Clinic, 1988 – 1998.

1999 Van Rensburg K. Comparison of liquid-based cytology with conventional cytology.

2003 Shanahan S. Cross-sectional analysis of 1000 women presenting to a health facility with the complaint of rape.

2009 Banda EC. Retrospective analysis of recurrence of disease post LLETZ.

2012 Moodley A. Sexual function in cervical cancer patients post chemo-radiotherapy.

2012 Krick D. Study of efficacy of Ketamine analgesia for surgical management of incomplete miscarriage.

2014 Msusu A. Radical Hysterectomy for cervical cancer FIGO stage IB1 at Groote Schuur Hospital: A 7 year audit (2000- 2007)

2014 Hendricks A. A retrospective audit of the management and outcome with borderline ovarian tumours.

2014 Kadwa K. Audit of women managed with cone biopsy at Groote Schuur Hospital.

15 LEADERSHIP AND ADMINISTRATION

7.1 University

7.1.1 Faculty of Health Sciences, University of Cape Town:

 Member of Board of Faculty since 1999  Member Post Graduate Programmes Accreditation Committee (2003 – date)  Member Transformation and Equity Committee (2003 – 2010)  Principal architect of University of Cape Town policy on Sexual Harassment (2004)  Member of Committee appointed by the Dean to Evaluate the Education Development Unit, under chairmanship of Professor Sue Kidson (2004)  Member of Ad Hominem Promotions Committee (2003, 2004, 2007, 2010, 2012)  Portfolio Manager for Gender, Faculty of Health Sciences (2004 – 2006)  Member Senior Management Team of Faculty of Health Sciences (2004 – 2009)  Member Sexual Harassment Reference Group tasked with creating policies on management of sexual harassment and rape within the University of Cape Town – April 2006  Member of Senate, University of Cape Town, January 2007 -  Dean’s Advisory Committee  Member of Joint Standing Advisory Committee, April 2016

7.1.3 Departmental Functions:

 Since January 2010 appointed to Head of Department Obstetrics & Gynaecology

 Principal Specialist in Department of Obstetrics and Gynaecology  Convenor of Fifth Year Gynaecology Teaching 1994 - 2005  Designed Women’s Health curriculum for Semesters 6, 7/8 and 9/10.  Course convenor for gynaecology semesters 7 and 8 of New Curriculum until 2006  Editor and Contributor, Fifth Year Gynaecology Lecture Notes, revised 2005  Preparation registrars for Part I and Part II of College Exams  Member of Departmental Teaching Committee  Member of Departmental Research Committee  Contributor to Gynaecology Oncology/Radiation Oncology Protocol Book  Management of Departmental Library  Chair Departmental EXCO  Chair Departmental Academic Support Fund  Chair of the panel for the Academic Review of the Department of Psychiatry & Mental Health

7.2 Hospital Committees

1. Combined Clinical Committee (CCCC) 2. Transformation Forum

Since becoming Head of Department, I have instituted a number of projects which include:  Raising money from Foschini to create three new patient lounges for the Maternity Centre at Groote Schuur Hospital  Raising money from Clicks to do a R1 million renovation of the entrance and waiting rooms of the Maternity Centre  Raising money to redecorate and upgrade the Department from Merck/MSD  Raised money from Medi-Clinic to upgrade and redecorate student lecture theatre in our Department  Created a Registrar EXCO and a Departmental EXCO to enable more transparent and responsive governance  Three senior consultants have been sent for Executive Coaching and 5 consultants have been sent overseas for training in Laparoscopic Surgery  Two consultants have gone on a Leadership training course at Graduate School of Business, one on a Research Methods training course in Austria, another on a laparoscopic surgical training course in Germany

7.3 Professional Organisations

Health Professionals Council of South Africa College of Medicine of South Africa Medical Protection Society

Medical Association of South Africa International Gynaecology Cancer Society FIGO – Co chair of Gynaecology Oncology Committee African Organisation for Research and Training in Cancer (AORTIC) – Secretary Treasurer

7.4 Extension Services

1. Services for Women who have been Raped

 Groote Schuur Hospital Protocol for Management of Survivors of Sexual Assault: This 14 page document was designed to improve the clinical and forensic examination of women who have been raped (in collaboration with Dr L Martin of Forensic Pathology). This protocol and accompanying policy was formally adopted by the Provincial Health Department and the Provincial Justice Department as the formal Rape Protocol for the Western Cape in December 2000. It is being distributed widely to health facilities throughout the Western Cape

2. Submissions to Parliamentary Portfolio Committee on Health on the Choice of Termination of Pregnancy Act, 1996

 1995: Personal submission and submission as part of Reproductive Health Alliance in support of the new Act

 2000: Submission (invited) on the Implementation of the above Act.

3. Submission to Parliamentary Portfolio Committee on Gender Equality on behalf of Groote Schuur Hospital, on the use of anti-retrovirals to prevent HIV Transmission in Women who have been raped. October 2001

4. Submission to Parliamentary Portfolio Committee on Justice regarding provision of antiretroviral medication to survivors of sexual assault. November 2003

5. Training of health professionals in African and other Countries

1. Dr Hulda Lugoe, Ocean Road Cancer Institute, Dar-Es-Salaam, Tanzania. Funded by UICC Fellowship. April 1999 2. Professor Ojwang, Head of Department Obstetrics & Gynaecology, Nairobi Hospital, Kenya. Funded by the International Atomic Energy Board, Geneva. October 1999

3. Dr Nelly Mugo, Nairobi Hospital, Kenya. Funded as UICC fellow, in colposcopy. May 2001

4. Dr Yinka Olaniyan, Abuja, Nigeria. Funded as UICC fellow, in colposcopy, June – September 2001

5. Associate Professor Neerja Bhatla, All India Institute of Medical Sciences, New Delhi, India. UICC fellow in gynaecology oncology, May 2003 6. Dr Walter Konya, Nairobi Hospital, Kenya. May 2004 7. Dr Victor Oboro, Nigeria, September 2004 8. Dr N Waithaka, Nairobi Hospital, Kenya. September – November 2005 funded by International Gynecology Cancer Society – September 2005 – November 2005 9. Dr Femi Akinsanyo, Nigeria – funded by International Gynecology Cancer Society – Jan – April 2007 10. Dr Christian Makwe, Lagos University Teaching Hospital, Nigeria – May – July 2008 11. Dr Rwamwejo (Gynaecologist), Dr Birigimana (Pathologist), Dr Kanimba (Gynaecologist) and Mr J Hakizimana (nursing sister), health care professionals from Kigali, Rwanda. Training in colposcopy and management of cervical disease for the Women’s Interagency HIV Cohort Study which is launching a similar project in Rwanda – May 2009 – July 2010

12. Dr Shahila Tayib, Consultant, Department of Obstetrics and Gynaecology, Hospital Taiping, Malaysia – February – October 2010

13. Dr Rakiya Saidu, Lecturer, Department of Obstetrics and Gynaecology, University of Ilorin, Nigeria – August 2013 – December 2017

14. Dr Bothwell Guzha, Lecturer, Department of Obstetrics and Gynaecology, University of Zimbabwe - February 2016 – January 2018

Campaign against sexual harassment

I generated the idea to begin a campaign against sexual harassment at both the Faculty of Health Sciences at UCT and Groote Schuur Hospital. The campaign represents a collaborative

82 | P a g e CVSEPTEMBER2016 effort with the advertising agency, Saatchi and Saatchi, who provided the creative input as a gift. The campaign started on April 7 2004 and was completed 2005. 16 17 CLINICAL SERVICE, COMMUNITY OUTREACH AND POLICY INPUT

1. Zibonele Radio, Local Community Radio Station, Khayelitsha -

Regular contributor to phone-in programmes on women’s health

2. Video Documentary on Women’s Experience of Cervical Cancer called ‘Silence of the Wombs’ and directed by Athalie Crawford, funded by Bill & Melinda Gates Foundation -

Concept, script, interviewing of subjects and editing.

3. Diaries of my Womanhood -

A theatre play written and directed by Ithumeleng wa-Lehulere. My role was to conceive of the play, to give advice, to assist with the writing and research. The play was first shown on Monday May 5, 2003. Funded by Bill & Melinda Gates Foundation through Alliance for Cervical Cancer Prevention

MEMBERSHIP OF SOCIETIES – NATIONAL AND INTERNATIONAL

Membership

1984 - present National Medical and Dental Council (now Health Professionals Council of South Africa) 1986 - 1989 Academy of General Practitioners of South Africa 1989 - present South African Medical Association 1994 - present South African Society of Obstetricians and Gynaecologists 1995 - present International Society of Gynaecological Cancer Executive Council (elected 2004 for 4 year term) Education Committee

2002 – present South African Society of Gynaecology Oncology 2002 - present Institute for Infectious Diseases and Molecular Medicine, University

of Cape Town 2003 - present African Organization for Research and Training in Cancer

OFFICES HELD

1984 – 2010 Member Rape Crisis Cape Town

1985 – 1988 Committee Member, Shelter for Battered Women, NICRO, Cape Town

1996 – 1999 Regional Council, Cancer Association of South Africa (Western Cape Branch)

1999 – 2002 Chairperson, Board of Trustees, Rape Crisis, Cape Town

2002 – 2007 Educational Committee of International Gynecologic Cancer Society (IGCS)

2003 – 2006 Portfolio manager for Gender, Faculty of Health Sciences

2003 – present Secretary-Treasurer, African Organisation for Research and Training in Cancer (AORTIC)

2004 – 2008 Elected to Executive Council of International Gynecologic Cancer Society (IGCS) for Africa and Middle East for four year period

2004 – 2015 Appointed to FIGO (International Federation of Gynecology and Obstetrics) Gynaecological Cancer Committee

2005 – 2007 Chair, FIGO HPV Study Group

2006 – 2011 Co-chair of FIGO Gynecology Cancer Committee

2012 Chair FIGO Gynecology Cancer Committee

2012 – 2014 President Elect, International Gynecologic Cancer Society

2015 Expert Panel member of American Society of Clinical Oncology

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