THYROID CANCER STRUCTURED REPORTING PROTOCOL (2Nd Edition 2020)
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Contents 1 Tumours of the pituitary gland 11 Spindle epithelial tumour with thymus-like differentiation 123 WHO classifi cation of tumours of the pituitary 12 Intrathyroid thymic carcinoma 125 Introduction 13 Paraganglioma and mesenchymal / stromal tumours 127 Pituitary adenoma 14 Paraganglioma 127 Somatotroph adenoma 19 Peripheral nerve sheath tumours 128 Lactotroph adenoma 24 Benign vascular tumours 129 Thyrotroph adenoma 28 Angiosarcoma 129 Corticotroph adenoma 30 Smooth muscle tumours 132 Gonadotroph adenoma 34 Solitary fi brous tumour 133 Null cell adenoma 37 Haematolymphoid tumours 135 Plurihormonal and double adenomas 39 Langerhans cell histiocytosis 135 Pituitary carcinoma 41 Rosai–Dorfman disease 136 Pituitary blastoma 45 Follicular dendritic cell sarcoma 136 Craniopharyngioma 46 Primary thyroid lymphoma 137 Neuronal and paraneuronal tumours 48 Germ cell tumours 139 Gangliocytoma and mixed gangliocytoma–adenoma 48 Secondary tumours 142 Neurocytoma 49 Paraganglioma 50 3 Tumours of the parathyroid glands 145 Neuroblastoma 51 WHO classifi cation of tumours of the parathyroid glands 146 Tumours of the posterior pituitary 52 TNM staging of tumours of the parathyroid glands 146 Mesenchymal and stromal tumours 55 Parathyroid carcinoma 147 Meningioma 55 Parathyroid adenoma 153 Schwannoma 56 Secondary, mesenchymal and other tumours 159 Chordoma 57 Haemangiopericytoma / Solitary fi brous tumour 58 4 Tumours of the adrenal cortex 161 Haematolymphoid tumours 60 WHO classifi cation of tumours of the adrenal cortex 162 Germ cell tumours 61 TNM classifi -
California Tumor Tissue Registry
CALIFORNIA TUMOR TISSUE REGISTRY California Tumor Tissue Registry c/o: Department ofPathol ogy and Human Anatomy Lorna Linda University School ofMedicine 11021 Campus Avenue, AH 335 Loma Linda, Cnllfomin 92350 (909) 824-4788 FAX: (909) 478-4188 Target audience: Practicing pathologists and pathology residen.ts. Goal: To acquaint the participant with the histologic features of a variety of benign and malignant neoplasms and tumor-like conditions. Oblectlve: The participant will be able to recognize morphologic features of a variety of benign and malignant neoplasms and tumor-like conditions and relate those processes to pertinent references in the medical literature. Educational methods and media: Review of representative glass slides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected references from the medical literature. Principal faculty: Weldon K. Bullock, MD Donald R. Chase, MD CME Credit: The CTTR designates this activity for up to 2 hours of continuing medical education. Participants must return their diagnoses to the CTTR as documentation of participation in this activity. Accreditation: The California Tumor Tissue Registry is accredited by the California Medical Association as a provider of continuing medical education. CONTRIBUTOR: Shelley L. Tepper, M.D. CASE NO. 1 • JANUARY 1997 San Francisco, CA TISSUE FROM: Thyroid ACCESSION #25451 CLINICAL ABSTRACf: This 34"year-old gay Caucasian male with generalized lymphadenopathy presented with a left neck mass. A few weeks later, a right neck mass developed. A total thyroidectomy was performed. GROSS PATHOLOGY: The right lobe of this 48 gram total thyroidectomy specimen vias markedly larger than the left and measured 7.0 x 3.0 x 4.0 em in greatest dimension. -
Evaluation of Head and Neck Masses in Adults
Evaluation of Head and Neck Masses in Adults Kristi Chang, MD Associate Professor Department of Otolaryngology-Head and Neck Surgery University of Iowa Hospitals and Clinics Annual Refresher Course for the Family Physician April 2018 1 Objectives Recognize when practitioners should worry about head and neck adenopathy Identify what are common serious causes of cervical lymphadenopathy and neck masses Understand how location of a neck mass guides differential diagnosis Identify indications warranting a biopsy of a neck mass and referral to an otolaryngologist 2 Neck mass –Background Definition: abnormal lesion that is visible, palpable, or seen on imaging study – can be acquired or congenital Location: – below mandible, above clavicle, deep to skin Etiologies can be varied – Adult neck masses are more likely to be malignant neoplasms – Persistent neck masses should be considered malignant until proven otherwise 3 Neck Mass - History What is the Age of patient? • Adults > 40 yrs old ~ 80% of neck masses are neoplastic (except thyroid) • Peds neck masses ~ 80% infectious/inflammatory • 16-40 yrs ~ 30% neoplastic, 50% infectious/inflammatory What is the DURATION of the mass? What is the LOCATION of mass? Duration and location are key factors in developing differential diagnosis Any new, persistent lateral neck mass in an adult > 40 yrs old is likely to be malignant Many upper aerodigestive tract cancers present with the chief concern of a painless neck mass 4 Neck Mass - Duration impacts Etiology • Traumatic: hematoma, vascular injury • Infectious/Inflammatory: • adenopathy from viral or bacterial infection . ACUTE : onset over days • odontogenic . more likely to be symptomatic • salivary gland • Neoplastic process more likely: • metastatic from upper aerodigestive • tract mucosa . -
Central Nervous System Tumors General ~1% of Tumors in Adults, but ~25% of Malignancies in Children (Only 2Nd to Leukemia)
Last updated: 3/4/2021 Prepared by Kurt Schaberg Central Nervous System Tumors General ~1% of tumors in adults, but ~25% of malignancies in children (only 2nd to leukemia). Significant increase in incidence in primary brain tumors in elderly. Metastases to the brain far outnumber primary CNS tumors→ multiple cerebral tumors. One can develop a very good DDX by just location, age, and imaging. Differential Diagnosis by clinical information: Location Pediatric/Young Adult Older Adult Cerebral/ Ganglioglioma, DNET, PXA, Glioblastoma Multiforme (GBM) Supratentorial Ependymoma, AT/RT Infiltrating Astrocytoma (grades II-III), CNS Embryonal Neoplasms Oligodendroglioma, Metastases, Lymphoma, Infection Cerebellar/ PA, Medulloblastoma, Ependymoma, Metastases, Hemangioblastoma, Infratentorial/ Choroid plexus papilloma, AT/RT Choroid plexus papilloma, Subependymoma Fourth ventricle Brainstem PA, DMG Astrocytoma, Glioblastoma, DMG, Metastases Spinal cord Ependymoma, PA, DMG, MPE, Drop Ependymoma, Astrocytoma, DMG, MPE (filum), (intramedullary) metastases Paraganglioma (filum), Spinal cord Meningioma, Schwannoma, Schwannoma, Meningioma, (extramedullary) Metastases, Melanocytoma/melanoma Melanocytoma/melanoma, MPNST Spinal cord Bone tumor, Meningioma, Abscess, Herniated disk, Lymphoma, Abscess, (extradural) Vascular malformation, Metastases, Extra-axial/Dural/ Leukemia/lymphoma, Ewing Sarcoma, Meningioma, SFT, Metastases, Lymphoma, Leptomeningeal Rhabdomyosarcoma, Disseminated medulloblastoma, DLGNT, Sellar/infundibular Pituitary adenoma, Pituitary adenoma, -
Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: an Overview Comparing Pediatric and Adult Populations
cancers Review Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations 1, 2, 2 3 Aline Rangel-Pozzo y, Luiza Sisdelli y, Maria Isabel V. Cordioli , Fernanda Vaisman , Paola Caria 4,*, Sabine Mai 1,* and Janete M. Cerutti 2 1 Cell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada; [email protected] 2 Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo/EPM, São Paulo, SP 04039-032, Brazil; [email protected] (L.S.); [email protected] (M.I.V.C.); [email protected] (J.M.C.) 3 Instituto Nacional do Câncer, Rio de Janeiro, RJ 22451-000, Brazil; [email protected] 4 Department of Biomedical Sciences, University of Cagliari, 09042 Cagliari, Italy * Correspondence: [email protected] (P.C.); [email protected] (S.M.); Tel.: +1-204-787-2135 (S.M.) These authors contributed equally to this paper. y Received: 29 September 2020; Accepted: 26 October 2020; Published: 27 October 2020 Simple Summary: Papillary thyroid carcinoma (PTC) represents 80–90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence clinical and biological behavior in both children and adults. In this review, we focus on the comparison between pediatric and adult PTC, highlighting genetic alterations, telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers. Abstract: Thyroid cancer is a rare malignancy in the pediatric population that is highly associated with disease aggressiveness and advanced disease stages when compared to adult population. -
Case Report: Primary Thyroid Lymphoma Presenting As a Rapidly Enlarging Thyroid Mass
Endocrinology & Metabolism International Journal Case Report Open Access Case report: primary thyroid lymphoma presenting as a rapidly enlarging thyroid mass Abstract Volume 1 Issue 1 - 2014 Primary thyroid lymphoma is a rarely encountered clinical entity that occurs mainly in G Papadakis,1 A Tertipi,1 M Papazian,2 K elderly females. We present a case of B-cell origin thyroid lymphoma. The diagnosis was 1 1 made by combined histology and immunochemistry. A 79-year-old woman presented with Moustakas, A Pappas 1Department of Endocrinology and Diabetes Center, Metaxa an enlarging neck mass with compression signs, dysphagia and pressure sensation around Anticancer Hospital, Greece the neck. On admission, the sonogram of the thyroid gland showed an enlarged mass and 2Department of Pathology, Metaxa Anticancer Hospital, Greece CT scan demonstrated diffuse enlargement of the thyroid extending on the anterior chest wall. After total thyroidectomy, the histological investigation revealed the presence of a Correspondence: Georgios Papadakis, Department of diffuse large B-cell non-Hodgkin’s lymphoma without other loci from the systemic staging. Endocrinology and Diabetes Center, Metaxa Anticancer The patient underwent chemotherapy and radiation therapy. Clinicians should include Hospital, Mpotasi 51, Pireaus 18537, Athens, Greece, Tel primary thyroid lymphoma in the differential diagnosis of a rapidly enlarging thyroid mass. 00306932598392, Email Keywords: primary thyroid lymphoma, non-hodgkin lymphoma, thyroid cancer Received: October 21, 2014 | Published: November 15, 2014 Abbreviations: PTL, primary thyroid lymphomas; MALT, On admission three months later, the symptoms deteriorated. mucosa associated lymphoid tissue Clinical examination revealed a firm, immobile and painless mass descending in the anterior chest wall. -
Current and Future Role of Tyrosine Kinases Inhibition in Thyroid Cancer: from Biology to Therapy
International Journal of Molecular Sciences Review Current and Future Role of Tyrosine Kinases Inhibition in Thyroid Cancer: From Biology to Therapy 1, 1, 1,2,3, 3,4 María San Román Gil y, Javier Pozas y, Javier Molina-Cerrillo * , Joaquín Gómez , Héctor Pian 3,5, Miguel Pozas 1, Alfredo Carrato 1,2,3 , Enrique Grande 6 and Teresa Alonso-Gordoa 1,2,3 1 Medical Oncology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; [email protected] (M.S.R.G.); [email protected] (J.P.); [email protected] (M.P.); [email protected] (A.C.); [email protected] (T.A.-G.) 2 The Ramon y Cajal Health Research Institute (IRYCIS), CIBERONC, 28034 Madrid, Spain 3 Medicine School, Alcalá University, 28805 Madrid, Spain; [email protected] (J.G.); [email protected] (H.P.) 4 General Surgery Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain 5 Pathology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain 6 Medical Oncology Department, MD Anderson Cancer Center, 28033 Madrid, Spain; [email protected] * Correspondence: [email protected] These authors have contributed equally to this work. y Received: 30 June 2020; Accepted: 10 July 2020; Published: 13 July 2020 Abstract: Thyroid cancer represents a heterogenous disease whose incidence has increased in the last decades. Although three main different subtypes have been described, molecular characterization is progressively being included in the diagnostic and therapeutic algorithm of these patients. In fact, thyroid cancer is a landmark in the oncological approach to solid tumors as it harbors key genetic alterations driving tumor progression that have been demonstrated to be potential actionable targets. -
Updates on the Genetics of Neuroendocrine Tumors
Updates on the Genetics of Neuroendocrine Tumors NET Patient Conference March 8, 2019 Anna Raper, MS, CGC Division of Translational Medicine and Human Genetics No disclosures 2 3 Overview 1. Cancer/tumor genetics 2. Genetics of neuroendocrine tumors sciencemag.org 4 The Genetics of Cancers and Tumors Hereditary v. Familial v. Sporadic Germline v. somatic genetics Risk When to suspect hereditary susceptibility 5 Cancer Distribution - General Hereditary (5-10%) • Specific gene variant is inherited in family • Associated with increased tumor/cancer risk Familial (10-20%) • Multiple genes and environmental factors may be involved • Some increased tumor/cancer risk Sporadic • Occurs by chance, or related to environmental factors • General population tumor/cancer risk 6 What are genes again? 7 Normal gene Pathogenic gene variant (“mutation”) kintalk.org 8 Cancer is a genetic disease kintalk.org 9 Germline v. Somatic gene mutations 10 Hereditary susceptibility to cancer Germline mutations Depending on the gene, increased risk for certain tumor/cancer types Does not mean an individual WILL develop cancer, but could change screening and management recommendations National Cancer Institute 11 Features that raise suspicion for hereditary condition Specific tumor types Early ages of diagnosis compared to the general population Multiple or bilateral (affecting both sides) tumors Family history • Clustering of certain tumor types • Multiple generations affected • Multiple siblings affected 12 When is genetic testing offered? A hereditary -
Follicular Variant of Papillary Thyroid Cancer Encapsulated, Nonencapsulated, and Diffuse: Distinct Biologic and Clinical Entities
ORIGINAL ARTICLE Follicular Variant of Papillary Thyroid Cancer Encapsulated, Nonencapsulated, and Diffuse: Distinct Biologic and Clinical Entities Sachin Gupta, MD; Oluyomi Ajise, MD; Linda Dultz, MD; Beverly Wang, MD; Daisuke Nonaka, MD; Jennifer Ogilvie, MD; Keith S. Heller, MD; Kepal N. Patel, MD Objective: To examine genotypic and clinical differ- tions in BRAF, H-RAS 12/13, K-RAS 12/13, N-RAS 12/13, ences between encapsulated, nonencapsulated, and dif- H-RAS 61, K-RAS 61, N-RAS 61, and RET/PTC1. fuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), Results: No patient with EFVPTC had central lymph node to characterize the entities and identify predictors of their metastasis, and in this group, 1 patient (4.5%) had a BRAF behavior. V600E mutation and 2 patients (9%) had RAS mutations. Of the patients with NFVPTC, none had central lymph Design: Retrospective medical chart review and mo- node metastasis (PϾ.99) and 2 (11%) had a BRAF V600E lecular analysis. mutation (P=.59). Of the patients with diffuse FVPTC, all had central lymph node metastasis (PϽ.001), and 2 (50%) Setting: Referral center of a university hospital. had a BRAF V600E mutation (P=.06). Patients: The pathologic characteristics of 484 con- Conclusions: FVPTC consists of several distinct sub- secutive patients with differentiated thyroid cancer who types. Diffuse FVPTC seems to present and behave in a underwent surgery by the 3 members of the New York more aggressive fashion. It has a higher rate of central University Endocrine Surgery Associates from January nodal metastasis and BRAF V600E mutation in compari- 1, 2007, to August 1, 2010, were reviewed. -
Follicular Variant of Papillary Thyroid Carcinoma Arising from a Dermoid Cyst: a Rare Malignancy in Young Women and Review of the Literature
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Available online at www.sciencedirect.com Taiwanese Journal of Obstetrics & Gynecology 51 (2012) 421e425 www.tjog-online.com Case Report Follicular variant of papillary thyroid carcinoma arising from a dermoid cyst: A rare malignancy in young women and review of the literature Cem Dane a,*, Murat Ekmez a, Aysegul Karaca b, Aysegul Ak c, Banu Dane d a Department of Gynecology and Obstetrics, Haseki Training and Research Hospital, Istanbul, Turkey b Department of Family Medicine, Haseki Training and Research Hospital, Istanbul, Turkey c Department of Pathology, Haseki Training and Research Hospital, Istanbul, Turkey d Department of Gynecology and Obstetrics, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey Accepted 3 November 2011 Abstract Objective: Benign or mature cystic teratomas, also known as dermoid cysts, are composed of mature tissues, which can contain elements of all three germ cell layers. Malignant transformation of a mature cystic teratoma is more common in postmenopausal women, however, it can also, rarely, be identified in younger women. We present a case of a 19-year-old woman with malignant transformation of an ovarian mature cystic teratoma. Case Report: Our case was a 19-year-old woman, who was diagnosed postoperatively with follicular variant of papillary thyroid carcinoma in a mature cystic teratoma. She underwent right cystectomy for adnexal mass. Postoperative metastatic workup revealed a non-metastatic disease and the patient did not undergo any further treatment. After 2 months, a near-total thyroidectomy was performed. Serum thyroglobulin levels were monitored on follow-up and the patient is asymptomatic. -
Multiple Endocrine Neoplasia Type 2: an Overview Jessica Moline, MS1, and Charis Eng, MD, Phd1,2,3,4
GENETEST REVIEW Genetics in Medicine Multiple endocrine neoplasia type 2: An overview Jessica Moline, MS1, and Charis Eng, MD, PhD1,2,3,4 TABLE OF CONTENTS Clinical Description of MEN 2 .......................................................................755 Surveillance...................................................................................................760 Multiple endocrine neoplasia type 2A (OMIM# 171400) ....................756 Medullary thyroid carcinoma ................................................................760 Familial medullary thyroid carcinoma (OMIM# 155240).....................756 Pheochromocytoma ................................................................................760 Multiple endocrine neoplasia type 2B (OMIM# 162300) ....................756 Parathyroid adenoma or hyperplasia ...................................................761 Diagnosis and testing......................................................................................756 Hypoparathyroidism................................................................................761 Clinical diagnosis: MEN 2A........................................................................756 Agents/circumstances to avoid .................................................................761 Clinical diagnosis: FMTC ............................................................................756 Testing of relatives at risk...........................................................................761 Clinical diagnosis: MEN 2B ........................................................................756 -
Classification and General Considerations of Thyroid Cancer
Central Annals of Clinical Pathology Review Article *Corresponding author Hiroshi Katoh, Department of Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Classification and General Sagamihara, 252-0374, Japan, Tel: 81-42-778-8735; Fax:81-42-778-9556; Email: Submitted: 22 December 2014 Considerations of Thyroid Accepted: 12 March 2015 Published: 13 March 2015 Cancer ISSN: 2373-9282 Copyright Hiroshi Katoh*, Keishi Yamashita, Takumo Enomoto and © 2015 Katoh et al. Masahiko Watanabe OPEN ACCESS Department of Surgery, Kitasato University School of Medicine, Japan Keywords Abstract • Thyroid cancer • Pathological classification Thyroid cancer is the most common malignancy in endocrine system, composed of • Genetic alteration four major types; papillary thyroid carcinoma, follicular thyroid carcinoma, anaplastic thyroid carcinoma, and medullary thyroid carcinoma. The incidence of thyroid cancer, especially differentiated thyroid cancer, is increasing in developed countries. Growing body of studies on molecular pathogenesis in thyroid cancer provide clues for further research and diagnostic/therapeutic targets. The general pathological classifications and clinical features of follicular cell derived thyroid carcinomas are overviewed, and recent advances of genetic alterations are discussed in this review. ABBREVIATIONS growth. PTC consists of 85-90% of all thyroid cancer cases, followed by FTC (5-10%) and MTC (about 2%). ATC accounts for PTC: Papillary Thyroid Cancer; FTC: Follicular Thyroid less than 2% of thyroid cancers and typically arises in the elder Cancer; ATC: Anaplastic Thyroid Cancer; MTC: Medullary patients. Its incidence continues to rise with age. The mechanism Thyroid Cancer; PDTC: Poorly Differentiated Thyroid Cancer; of MTC carcinogenesis is the activation of RET signaling caused DTC: Differentiated Thyroid Cancer by RET mutations [6], which are not observed in follicular INTRODUCTION thyroid cell derived cancers.