JOURNAL of VIROLOGY VOLUME 61 * DECEMBER 1987 * NUMBER 12 Arnold J

JOURNAL OF VIROLOGY VOLUME 61 * DECEMBER 1987 * NUMBER 12 Arnold J. Levine, Editor in Chief Thomas E. Shenk, Editor (1989) (1989) Princeton University Princeton University Princeton, N.J. Princeton, N.J. Anna Marie Skalka, Editor (1989) Bernard N. Fields, Editor (1988) Fox Chase Cancer Center Harvard Medical School Philadelphia, Pa. Boston, Mass. George F. Vande Woude, Editor (1992) Robert A. Lamb, Editor (1992) NCI-Frederick Cancer Research Facility Northwestern University Frederick, Md. Evanston, Ill. Robert A. Weisberg, Editor (1988) Michael B. A. Oldstone, Editor (1988) National Institute of Child Health Scripps Clinic & Research Foundation and Human Development La Jolla, Calif. Bethesda, Md. EDITORIAL BOARD James Alwine (1988) Walter Gerhard (1989) Warren Masker (1987) Joseph Sambrook (1988) David Baltimore (1987) Joseph C. Glorioso (1989) Thomas Merigan (1989) Charles E. Samuel (1989) Tamar Ben-Porat (1987) Stephen P. Goff (1988) George Miller (1987) Priscilla A. Schaffer (1987) Kenneth I. Berns (1988) Larry M. Gold (1988) Lois K. Miller (1988) Sondra Schlesinger (1989) Michael Botchan (1989) Hidesaburo Hanafusa (1989) Peter Model (1989) Manfred Schubert (1988) Thomas J. Braciale (1988) John Hassell (1989) Bernard Moss (1989) Bart Sefton (1988) Joan Brugge (1988) William i. Hayward (1987) Opendra Narayan (1988) Bert L. Semler (1989) Michael J. Buchmeier (1989) Roger Hendrix (1987) Joseph R. Nevins (1988) Charles J. Sherr (1987) Barrie J. Carter (1987) John J. Holland (1987) Erling Norrby (1989) Saul J. Silverstein (1988) John M. Coffin (1989) Nancy Hopkins (1989) Nancy G. Nossal (1987) Patricia G. Spear (1987) Charles N. Cole (1989) Peter M. Howley (1987) Dennis O'Callaghan (1989) Bruce Stillman (1988) Geoffrey M. Cooper (1987) Alice S. Huang (1987) J. Thomas Parsons (1989) Mark F. Stinski (1989) Neal Copeland (1989) Steve Hughes (1988) Ulf G. Pettersson (1989) James Strauss (1987) Donald Court (1987) Tony Hunter (1989) Lennart Philipson (1987) F. William Studier (1987) Richard Courtney (1989) Richard Hyman (1989) Lewis I. Pizer (1987) Lawrence S. Sturman (1988) Clyde S. Crumpacker II Nancy Jenkins (1989) Carol Prives (1989) John M. Taylor (1987) (1988) Jack D. Keene (1988) R. Frank Ramig (1988) Howard M. Temin (1988) Thomas Curran (1988) Thomas J. Kelly, Jr. (1988) Fred Rapp (1987) Inder Verma (1989) Walter Doerfler (1989) Elliott Kieff (1987) Dan S. Ray (1989) Edward K. Wagner (1989) Elvera Ehrenfeld (1989) David Knipe (1988) Solon L. Rhode (1989) Raymond M. Welsh, Jr. (1988) Robert N. Eisenman (1988) Daniel Kolakofsky (1989) Gordon M. Ringold (1987) Gail Wertz (1988) Suzanne U. Emerson (1989) Michael Lai (1988) Harriet Robinson (1988) Reed B. Wickner (1988) Mary K. Estes (1989) Robert A. Lazzarini (1987) William S. Robinson (1989) Eckard Wimmer (1988) Ellen Fanning (1988) Myron Levine (1988) Bernard Roizman (1988) Owen Witte (1989) Emanuel Faust (1987) Maxine Linial (1988) John K. Rose (1988) Charles Hamish Young (1989) S. Jane Flint (1987) Douglas R. Lowy (1989) Naomi Rosenberg (1989) Harald zur Hausen (1989) Donald Ganem (1988) Malcolm Martin (1989) Roland R. Rueckert (1988) Costa Georgopolous (1989) Robert Martin (1987) Norman P. Salzman (1987) Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director of Publications Linda M. Illig, Managing Editor, Journals Judith Nedrow, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, one volume per year. The nonmember subscription price is $350 per year; single copies are $25. The member subscription price is $41 (foreign, $56 [air drop shipping]) per year; single copies are $8.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). 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Ahmed, Rafi, 3920, 3930 Esteban, Mariano, 3910 Lairmore, Michael D., 4038 Roivainen, Merja, 3749 Akita, Geoffrey Y., 4038 Estes, Mary K., 3950 Lasky, Laurence A., 3804 Rosen, Anders, 3870 Aldrich, Carol E., 3832 Evans, Leonard H., 3783 Lawrence, William C., 4023 Rowe, Martin, 3870 Alter, Harvey J., 3804 Evinger-Hodges, Mary Jean, Lazaro, Josd M., 3983 Rubenstein, Richard, 3688 Anderson, Carl W., 3879 3774 Leonard, John, 3726 Russell, Helena 1., 4038 Anderson K., 3855 Leung, Kiu, 4033 Aoki, Naoto, 3848 Falgout, Barry, 3759 Levis, Robin, 3809 Sakai, Koji, 3774 Arquint, Monique, 3694 Fersko, Regina, 3688 Levy, Jay A., 3804 Salas, Margarita, 3983 Ashida, Kouichi, 4012 Feunteun, Jean, 3992 Lewis, James B., 3879 Salfeld, Jochen, 3701 Fichelson, Serge, 4043 Lewis, T. L., 3820 Sanwal, B. D., 3795 Baker, Susan C., 3968 Finke, Jurgen, 3870 Lien, Jau-Min, 3832 Schaller, Heinz, 3701 Ball, L. A., 3855 Flomenberg, Phyllis R., 3665 Lokensgard, J. R., 3820 Scheidtmann, Karl Heinz, Basilico, Claudio, 4055 Fraser, Nigel W., 3841 Lomniczi, Bela, 4030 3902 Beam, S. L., 3827 Freeman, J. Douglas, 4060 Love, Arthur, 3896 Scherneck, Siegfried, 3992 Bello, Leonard J., 4023 Fried, Mike, 3754 Schlicht, Hans J., 3701 Bellocq, Christine, 3960 Fujiwara, Kosaku T., 4012 Maa, Juehn-Shin, 3910 Seibl, Rudi, 3672 Benichou, Daniele, 3862 Fukushige, Shinichi, 3848 Mager, Dixie L., 4060 Sevoian, Martin, 3783 Ben-Porat, Tamar, 4030 Fultz, Patricia N., 4026 Marchioli, Carmine C., 3977 Shaw, James E., 4033 Berman, Phillip W., 3804 Mason, William S., 3832 Shen-Ong, Grace L. C., 3721 Bernad, Antonio, 3983 Gendelman, Howard E., 3726 Matsubara, Kenichi, 3848 Shieh, Chien-Kou, 3968 Beushausen, S., 3795 Ghiasi, Homayon, 3820 Mayfield, J. E., 3827 Shiga, Kiyoshi, 3848 Bhat, Bheem M., 3938 Girard, Marc, 3862 McClure, Harold M., 4026 Shinedling, Sidney, 3790 Blanco, Luis, 3983 Gisselbrecht, Sylvie, 4043 McClure, Jan, 3804 Smith, Marilyn S., 3769 Bordereaux, Didier, 4043 Gold, Larry, 3790 Merz, Patricia A., 3688 Soe, Lisa H., 3968 Bovi, Pasquale Delli, 4055 Gonda, Matthew A., 4046 Mettenleiter, Thomas C., 4030 Sola, Brigitte, 4043 Braun, Michael J., 4046 Goto, Naoaki, 3733 Miller, George, 3672 Spencer, John H., 3694 Bresser, Joel, 3774 Greene, Cornelia R., 4026 Miyajima, Nobuyuki, 4012 Spivack, Jordan G., 3841 Brian, E. Leigh, 3769 Gregory, Timothy, 3804 Moran, Patricia A., 3804 Srinivas, Ranga V., 4007 Butel, Janet S., 3950 Grussenmeyer, Thomas, 3902 Morein, Bror, 3896 Srinivasan, A., 4026 Butler, David, 4026 Gutierrez, Julio, 3983 Muller, Ulrich, 3710 Stevenson, Mario, 3741, 3774 Butler, Larry D., 3930 Murotsu, Tomoaki, 3848 Stott, E. J., 3855 Hermonat, Paul L., 3889 Strauss, James H., 3809 Carbone-Wiley, Arlene, 3902 Hermoso, Josd M., 3983 Nagaya, Tsutomu, 3848 Summers, Peter, 4019 Carp, Richard 1., 3688 Hirashima, Akikazu, 3946 Nagy, Eva, 3655 Swenson, R. Brent, 4026 Carpenter, Susan, 3783 Horswood, Robert, 4019 Nakamura, Takaaki, 3848 Chan, Wai-Kit, 3950 Horwitz, Marshall S., 3665 Narindrasorasak, S., 3795 Tambourin, Pierre E., 4043 Chang, Ming-Fu, 3968 Hovi, Tapani, 3749 Nesburn, Anthony B., 3820 Taylor, G., 3855 Chanh, Tran C., 3804 Howley, Peter M., 3889 Nishina, Hiroshi, 4012 Tegtmeyer, Peter, 3649 Chanock, Robert, 4019 Hu, Shiu-Lok, 3804 Nishizawa, Makoto, 3733, Timmins, James G., 3977 Chen, Mei, 3665 Huang, Henry V., 3809 4012 Tokino, Takashi, 3848 Chesebro, Bruce, 3783 Norbury, Christopher J., 3754 Tonna-DeMasi, Maria, 3688 Norrby, Erling, 3896 Chowdhury, Rukhsana, 3999 Iba, Hideo, 4012 Varsanyi, Tamas M., 3896 Clements, Janice E., 4046 Inokuchi, Yoshio, 3946 Vogel, Frank, 3992 Cobb, Kathy E., 3804 Ong, John, 3820 Volsky, David J., 3741, 3774 Compans, Richard W., 4007 Jamieson, Beth D., 3920, 3930 Ostrove, Jeffrey M., 3726 Countryman, Jill, 3672 Jarvis, Donald L., 3950 Walter, Gernot, 3902 Jenson, Hal, 3672 Pagano, Joseph S., 3769 Wechsler, Steven L., 3820 Dales, S., 3795 Palmenberg, Ann C., 3680 Weck, Karen E., 3726 Das, Jyotirmoy, 3999 Kallin, Bengt, 3870 Parks, Griffith D., 3680 Wertz, G. W., 3855 Deb, Swati Palit, 3649 Kaplan, Albert S., 4030 Parma, David, 3790 Whitbeck, J. Charles, 4023 Delmas, Veronique, 3992 Kascsak, Richard J., 3688 Petcu, David J., 3832 Wisniewski, Henryk M., 3688 DeMartini, James C., 4038 Kawai, Sadaaki, 3733, 4012 Petit, Robert G., 4033 Wold, William S. M., 3938 Dewhurst, Stephen, 3774 Kennedy, Ronald C., 3804 Petrovskis, Erik A., 3977 Wolf, Hans, 3672 Dillner, Joakim, 3870 Kern, Francis G., 4055 Porter, David D., 3920 Wolff, Linda, 3721 Diringer, Heino, 3688 Ketner, Gary, 3759 Post, Leonard E., 3977 Wychowski, Czeslaw, 3862 Dobos, Peter, 3655 Kilpatrick, David R., 4007 Prieto, Ignacio, 3983 Doerfler, Walter, 3710 King, A. M. Q., 3855 Prince, Gregory, 4019 Yancey, Robert J., Jr., 3977 Dreesman, Gordon R., 3804 Klein, George, 3870 Young, K. K.-Y., 3855 Duncan, Roy, 3655 Kolakofsky, Daniel, 3960 Rabson, Arnold B., 3726 Krell, Peter J., 3655 Ray, Anuradha, 3999 Zarling, Joyce M., 3804 Eckels, Kenneth, 4019 Ray, Prabir, 3999 Zhang, XinHua, 3741 Eichberg, Jorg W., 3804 Lai, Ching-Juh, 4019 Rice, Charles M., 3809 Zhao, Bangti, 4019 Ernberg, Ingemar, 3870 Lai, Michael M. C., 3968 Rock, D. L., 3820, 3827 Zsak, Laszlo, 4030 1988 APPLICATION FOR STUDENT MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1913 I Street, NW * Washington, D.C. 20006 * (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITTANCE IN U.S. FUNDS Eligibility Any matriculated student majoring in microbiology or a related field who has not earned a doctoral degree is eligible for election as a Student Member. Student Members have all the privileges of membership except the right to vote and hold office in the Society. 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Acs, George, 1108, 2921 Baron, Patricia A., 1851 Bloemers, Henri P. J., 2009 Caradonna, Sal, 3040 Adachi, Akio, 209, 1861 Baroudy, Bahige M., 50 Blondel, Danielle, 1391 Carbone, Arlene, 405 Adam, Stephen A., 3276 Barque, Jean Philippe, 579 Bloom, Marshall E., 81, 2407 Carbone, Kathryn M., 3431 Adams, Alice, 1743 Barrell, Barclay G., 125, 1358 Blumenthal, J. A., 1193 Carbone-Wiley, Arlene, 3902 Adams, Jerry M., 2754 Barrell, Bart, 446 Bockus, Beverly J., 1147, Cardiff, Robert, 308 Agut, H., 1722 Barthelemy, Isabel, 1751 1155, 1221 Carlson, Jonathan O., 621 Ahlers, Suzanne E., 1103, Basilico, Claudio, 4055 Bodemer, Walter, 2063 Carmichael, Gordon G., 2232 1258 Bassel-Duby, Rhonda, 1834 Bodescot, Myriam, 3120, Carp, Richard I., 42, 3688 Ahlquist, Paul, 1457 Bastin, Marcel, 2448 3340, 3424 Carpenter, Susan, 3783 Ahmed, Aftab, 29 Bates,'Robert C., 3612 Boerkoel, C., 2084 Carrasco, Luis, 233, 3319 Ahmed, Rafi, 1571, 3920, 3930 Bauer, M., 1821 Bolen, Joseph B., 1079, 3299 Carrigan, Donald R., 1919 Ahola, Harri, 2240, 3394 Bauskin, Asne R., 3589 Bolognesi, D., 2017 Carrington, James C., 2540 Air, G. M., 2910 Beam, S. L., 3827 Bonham, Lynn, 3072 Cartwright, Christine A., 1731 Akita, Geoffrey Y., 4038 Beards, Graham, 3365 Bonneau, Anne-Marie, 986 Casey, James W., 743 Akkina, Ramesh K., 2217 Beck, E., 1621 Bordereaux, Didier, 4043 Castrillo, Jose Luis, 3319 Alarc6n, Balbino, 233 Becker, Y., 2515 Borysiewicz, Leszek K., 3463 Cattaneo, Roberto, 904 Albrecht, Jens, 446 Beckes, J. David, 3470 Bosch, Dick L., 3607 Celander, Daniel, 269 Aldrich, Carol E., 2891, 3832 Bedell, Mary A., 3635 Botchan, Michael R., 2864 Cerini, Costantino P., 1532 Alexander, Fern, 534 Bednarik, Daniel P., 1253 Both, Gerald W., 1054 Chakrabarti, Sekhar, 516 Alexandersen, Soren, 81, 2407 Beemon, Karen, 2420 Botstein, David, 2316, 3621 Chambers, Thomas M., 1517, Alfieri, C., 3306 Beladi, Ilona, 2326 Bouchard, Louise, 2448 2217 Allen, George P., 2454 fBelin, Marie-Therese, 2559 Boulanger, Pierre, 2559 Champoux, James J., 2843 Alling, David W., 3163 Belkowski, Linda S., 653 Bourgaux, Pierre, 840, 845 Chan, Voon-Loong, 143 Almond, Jeffrey W., 2917 Bellamy,,A. Richard, 1054 Bouton, Amy, 2138 Chan, Wai-Kit, 1488, 3950 Alter, Harvey J., 3804 Bellinger-Kawahara, Carolyn, Bovi, Pasquale Delli, 4055 Chandrasekharappa, Settara Amati, P., 1615 159 Bowman, Michael R., 1992 C., 2973 Amini, Shohreh, 1079, 3299 Bello, Leonard J., 4023 Boyle, David B., 1054 Chang, Christopher, 3322 Amsbaugh, Suzanne C., 1682 Bellocq, Christine, 87, 1722, Boyle, John F., 185 Chang, Long-Sheng, 3096 Anders, E. Margot, 214 3960 Bradshaw, Harvey, 308 Chang, Lung-Ji, 921, 3401 Anderson,.Carl W., 3879 Belzer, Susan K., 1593 Brady, John, 2175 Chang, Ming-Fu, 3968 Anderson, Kevin, 293, 3855 Benchaibi, M., 3058 Branton, Philip E., 3227 Chanh, Tran C., 2024, 3804 Anderson, Kevin P., 787 Benchimol, Sam, 2777 Braun, Daniel, 945 Channell, Myra B., 2670 Anderson, Stephen K., 1893 Ben-David, Yaacov, 2777 Braun, Michael J., %2, 4046 Chanock, Robert M., 1851, Anderson, W. French, 1647 Bender, Michael A., 1639 Brazeau, P., 2046 4019 Andrew, Marion E., 1054 Benichou, Daniele, 3862 Breindl, Michael, 336 Chao, Shih-Fong, 735 Aoki, Naoto, 3848 Benjamin, David C., 1927 Bresser, Joel, 3774 Chao, Yeh-Shiu, 60 Araki, Masatake, 3543 Benjamin, Thomas L., 2232 Brian, E. Leigh, 3769 Chapes, Stephen K., 928 Argani, Pedram, 3326 Bennett, Michael, 2631 Brinton, Margo A., 3641 Charan, Shiv, 2509 Arlinghaus, Ralph B., 3625 Bennink, Jack R., 1098 Broi, Elisabetta, 561 Chatis, Pamela, 1704 Armentano, Donna, 1647 Ben-Porat, Tamar, 796, 1772, Broker, Thomas R., 1913, Chen, Ker-Sang, 2150 Arquint, Monique, 3694 2764, 4030 2581, 2599 Chen, Mei, 3665 Arraras, Ana, 2573 Berberich, Stanton L., 177 Brolaski, Mark N., 1261 Chen, Suzie, 3521 Arthur, Larry O., 629, 3173 Berger, Itzhak, 1180 Brown-Shimer, Sheryl, 326 Cheng, Kuo-Chi, 1286 Arya, Biragyn, 2326 Bergman, Per, 3394 Brownstein, David G., 1670 Cheng, Yung-chi, 2947 Asher, David M., 3173 Bergmann, Ingrid E., 419 Broyles, Steven S., 1738 Chen-Kiang, Selina, 1466 Ashida, Kouichi, 4012 Bergold, P. J., 1193 Bu, Ming, 912 Chesebro, Bruce, 3783 Ashley, Rhoda, 264 Berkner, Kathleen L., 1213, Buchmeier, M. J., 982 Chiodi, F., 1244 Asj6', B., 1244 1221 Buckler-White, Alicia J., 50, Chisari, F. V., 683 Askew, David S., 2339 Berman, Phillip W., 726, 1532, 2857 Chiu, Wah, 2319 Austin, J. B., 2109 3804 Buhring, Hans-Jorg, 3102 Chlan, Caryl A., 1855 Ayub, Jamshed, 2395 Bernad, Antonio, 3983 Buller, Richard S., 29 Choi, Yongwon, 3013 Bernstein, Alan, 2777 Buller, Robert M. L., 383 Chou, Min-Ji, 3491 Baczko, Knut, 472 Besmer, P., 1193 Burke, Kathy, 3491 Chow, Louise T., 1913, 2581, Baichwal, Vijay R., 866 Bestwick, Richard K., 2782 Burke, Rae Lyn, 315, 326 2599 Baker, A. T., 2910 Beushausen, S., 3795 Burkle, Alexander, 119 Chow, Virginia, 2777 Baker, Carl C., 962 Bhaduri, Leena M., 1019 Burlington, D. Bruce, 2150 Chowdhury, Rukhsana, 3999 Baker, Susan C., 3968 Bhat, Bheem M., 3938 Burns, John W., 1488 Christman, Judith K., 1108 Balachandran, N., 1125 Biberfeld, G., 2017 Buscher, Marita, 904 Chrystie, Ian, 3365 Ball, L. Andrew, 293, 1788, Biegalke, Bonita J., 1949, Butel, Janet S., 3950 Chung, Siu-Wah, 1661 2885, 3855 2138 Butler, David, 4026 Claesson-Welsh, L., 1 Baltimore, David, 1756 Biggart, Neal W., 2378 Butler, Larry D., 3930 Clark, Billy, 3365 Bamford, Dennis H., 2362 Biggin, Mark, 3120 Clarke, Jennifer, 3536 Bando, Hisanori, 553 Binn, Leonard N., 735 Cai, Weizhong, 714 Cleaver, James E.,159 Banker, Franklyn S., 2951 Bittle, James L., 8 Calenoff, Miriam, 1507 Clements, Janice E., 1019, Bankier, Alan T., 125 Blair, Christine C., 2499 Callahan, Robert, 66, 218, 1325, 4046 Barbosa, Miguel S., 2938 Blair, Donald, 1690 1651 Clerx, John P. M., 2319 Barkan, Alice, 3190 Blair, Edward D., 2499 Calothy, Georges, 1678, 2523, Cleveland, John L., 2339 Barklis, Eric, 2742 Blanco, C., 1540 2530 Coates, Laura, 916, 2891 Barncastle, John P., 2232 Blanco, Luis, 3983 Cameron, Keith R., 2063 Cobb, Kathy E., 3804 Barnier, Jean Vianney, 2523 Block, Timothy M., 2989 Campbell, M. E. M., 2428 Cobbold, S. P., 1867 ii AUTHOR INDEX J. VIROL.

Cobrinik, D., 1999 Derse, David, 743, 2462 Ensinger, Marcia J., 1842 French, Roy, 1457 Coffin, John M., 1171, 2659 DeSeau, Virginia, 1079, 3299 Epp, Chris, 3254 Frenkel, Niza, 2198 Cohen, E. A., 2046 DesGroseillers, Luc, 3266 Ericson, Brad, 1488 Freund, Robert, 2232 Cohen, Gary H., 1532 De Simone, V., 1615 Eriksson, Annika, 3394 Fried, Mike, 3754 Cohen, J. C., 1651 Desselberger, Ulrich, 3365 Ernberg, Ingemar, 3870 Friedman-Kien, Alvin, 1690 Cohen, Jeffrey I., 50, 3035 Detjen, Barbara Morgan, 16 Ernoult-Lange, Michele, 167 Friedmann, Adam, 898 Cohen, Maurice, 2182 Devaney, Margaret A., 3199 Esch, Frederick S., 597 Friel, Jutta, 889 Collett, Marc S., 1593 Dewalt, Patricia Gillis, 2162 Esteban, Mariano, 395, 2642, Friesen, Paul D., 661, 2264 Collins, Peter L., 3163, 3416 Dewhurst, Stephen, 3774 3550, 3910 Frisque, Richard J., 755 Colman, P. M., 2910 Dezelde, Philippe, 2523 Estes, Mary K., 1488, 3950 Fronko, Gerald E., 221 Compans, Richard W., 4007 Dezdlee, Sybille, 1391 Etchison, Diane, 2702, 2711 Fu, Shu Man, 1466 Compton, Susan R., 1814 Dharakul, Tararaj, 3345 Etchison, James R., 2702 Fuerstenberg, S., 1244 Consigli, Richard A., 375, Dickson, C., 480, 1651 Evans, Christopher L., 2033 Fujinami, Robert S., 3381 509, 1708, 2747, 2934 Diener, T. O., 159 Evans, Elizabeth, 3152 Fujita, Donald J., 1893, 2084 Cook, James L., 2155, 3510 Diggelmann, H., 1651 Evans, Leonard H., 1350, Fujiwara, Kosaku T., 4012 Cooper, Neil R., 1416 Dillner, Joakim, 3870 1882, 3783 Fukuoka, Katsuko, 1861 Copeland, Neal G., 2929 DiMaio, Daniel, 1248 Everett, Roger D., 2368 Fukushige, Shinichi, 3848 Copeland, Terry D., 629 Dina, Dino, 315, 326 Evinger-Hodges, Mary Jean, Fultz, Patricia N., 4026 Corey, Lawrence, 264 DiPaolo, Joseph A., 1061, 3774 Furlong, Deirdre, 2351 Corrias, Maria V., 561 1682 Ewalt, Larry C., 3314 Furman, Phillip, 2800 Cory, Suzanne, 2754 Diringer, Heino, 3688 Fyfe, James A., 2800 Costello, Teresa, 3222 Dixon, Kathleen, 1282 Fadly, A. M., 722 Cote, Paul J., 1318 Dixon, M., 480 Fahnestock, Margaret L., 247 Gage, Philip J., 3356 Cotmore, Susan F., 3612 Dobos, Peter, 3655 Falgout, Barry, 3759 Gajdusek, D. Carleton, 3173 Coulter, Charles, 1855 Dodgson, J. B., 2084 Fanning, Ellen, 2076 Gallahan, Daniel, 66, 218 Countryman, Jill, 3672 Doerfler, Walter, 344, 2719, Farber, Joshua M., 436 Gallick, Gary E., 2378 Coupar, Barbara E. H., 1054 3048, 3710 Farkas, Daniel H., 2989 Gallimore, Phillip H., 2793 Courtney, Richard J., 1735 Doermann, A. H., 2823, 2828, Farrell, Paul J., 1495, 3120, Gallo, Robert C., 570, 2017 Cowley, Jeff A., 2304 2835 3340, 3424 Gandrillon, O., 3058 Crawford, Sue E., 1488 Domingo, Esteban, 233 Fauci, Anthony S., 209, 3441 Ganem, Don, 35, 1672, 3241, Craxton, Molly, 2063 Donehower, Lawrence A., Feenstra, Veronica, 2208 3322 Cripe, Tim P., 3401 1964 Feijlbrief, Matty, 3607 Garber, Ellen A., 354, 2530 Crittenden, L. B., 722 Doniger, Jay, 1061 Feinstone, Stephen M., 3035 Garcia, Ernesto, 2573 Croissant, Odile, 3295 Doorbar, John, 2793 Feldman, Lawrence T., 1103, Garcia, Jose L., 2573 Cross, Frederick R., 1678 Dorn, Patricia L., 743 1258, 1855 Garcia, Pedro, 2573 Crowl, Robert M., 534 Dorney, D. J., 2691 Feller, Martha, 1061 Gardner, Murray B., 308, Crumpacker, Clyde, 1704 Dorsky, David, 1704 Felser, James M., 225 3066 Csobai, I., 1772 Dougherty, William G., 2540 Feng, Teng-Yung, 60 Gariglio, Patricio, 1002 Cutt, John R., 543 Dreesman, Gordon R., 3804 Fennie, Elizabeth H., 787 Garoff, Henrik, 1301 Dressler, Gregory R., 2770 Fenyo, E. M., 1244 Gattoni-Celli, Sebastiano, 209 Dahl, Karen, 1602 Dreyfuss, Gideon, 3276 Fernandez-Tomas, Carlos, Gaudreau, P., 2046 Dahmus, Michael E., 1002 Droge, Peter, 411 1002 Gauss-Muller, Verena, 3645 Daksis, Jasmine I., 143 Dubois, Garrett C., 1577 Fersko, Regina, 3688 Gautsch, James W., 1261 Dales, S., 3795 Dubois-Dalcq, Monique E., Fertsch, Diana, 812, 1814 Geerligs, Harm J., 3607 Dallo, Shatha, 2642 1332 Feunteun, Jean, 3992 Geiduschek, E. Peter, 597 Dambrine, Ginette, 2530 Duchala, Cynthia S., 3431 Fey, Stephen J., 3596 Gelinas, Richard E., 1639 Dandekar, Satya, 308 Dudley, J., 1651 Fichelson, Serge, 4043 Gelman, Irwin H., 2286, 3167 D'Andrea, E., 1193 Duncan, Roy, 3655 Fichot, O., 1722 Gendelman, Howard E., 209, Danho, Waleed, 534 Dunn, John J., 3199 Fields, Bernard N., 1834, 2351 3726 D'Aquila, Richard T., 1291 Dutschman, Ginger E., 2947 Finke, Jurgen, 3870 Gentsch, Jon R., 1407 Dartmann, K., 134 Duvall, J., 2175 Finlay, C., 2029 Genvrin, Patrice, 2523, 2530 Das, Jyotirmoy, 3999 Fischer-Fantuzzi, Lia, 2648 Gerard, R. D., 851 Dasgupta, Asim, 1781, 2997 Ebeling-Keil, Angelika, 526, Fischinger, Peter J., 629, 3173 Gerendasy, Dan D., 594 Daugherty, Daryl, 209 1901 Fiscus, Susan A., 2607, 2655 Gerhard, Walter, 1375 David-Pfeuty, Thdrese, 2530 Eberle, R., 1735 Fisher-Fantuzzi, Lia, 1296 Gerin, John L., 1318, 2891 Davidson, Dominique, 1226 Eckels, Kenneth, 4019 Fitting, Thomas, 3410 Ghiasi, Homayon, 3820 Davis, Gary L., 2981 Eckhart, Walter, 1731 Flaherty, Lorraine, 928 Giachetti, Cristina, 454 Davis, Jennifer L., 1325 Eckner, Robert J., 2631 Flanegan, James B., 611 Giam, Chou-Zen, 708 Davisson, M., 1651 Edris, Wade A., 2171 Fleckenstein, Bernhard, 119, Gibbs, Clarence J., Jr., 3173 Dawe, Clyde J., 2232 Ehrenfeld, Ellie, 802, 2307, 446, 1358, 2063 Gidlund, M., 1244 Dawson, Myra, 366 2480 Flint, S. J., 3335 Gielkens, A., 1772 Deb, Sumitra, 2143 Ehrlich, Garth, 1690 Flomenberg, Phyllis R., 3665 Gilboa, Eli, 1368, 1647 Deb, Swati Palit, 3649 Eichberg, Jorg W., 3804 Flore, Ornella, 561 Gilden, Raymond V., 1577, Defendi, Vittorio, 1655 Eisenberg, Roselyn J., 1532 Fox, Jay W., 239 2684 Deinhardt, Friedrich, 3645 Eisenlohr, Laurence C., 1375 Frame, M. C., 2428 Ginsberg, H. S., 3089 DeLange, A. M., 1957 Elder, John H., 8, 3410 Frankel, Gad, 898 Girard, Marc, 1722, 3862 de la Torre, Juan Carlos, 233 Ellis, Ronald W., 1796, 2951 Fraser, Nigel W., 2770, 3288, Giraudo, Ana T., 419 Delmas, Vdronique, 3992 Embretson, Janet E., 2675, 3841 Gish, Warren R., 2864 DeLuca, Neal A., 714 3454 Fredrickson, T. N., 383, 2109 Gisselbrecht, Sylvie, 579, 4043 DeLucia, Angelo L., 2143 Emerman, Michael, 925 Freed, Eric O., 2852 Glorioso, Joseph C., 2691, DeMartini, James C., 4038 Enders, Greg H., 35, 3322 Freeman, J. Douglas, 4060 3356 DePolo, Nicholas J., 454 England, James M., 916 Freese, Ulrich-Karl, 119 Gluzman, Yakov, 851, 3326 Deppert, Wolfgang, 3561 Enquist, Lynn W., 2691, 2962 Freisem-Rabien, Uta, 344 Gnann, John W., Jr., 2639 VOL. 61, 1987 AUTHOR INDEX iii

Goh, Wei Chun, 633 Heaney, Mark L., 2138 Hussain, Khalid A., 2956 Karam, Jim D., 366 Gojobori, Takashi, 553 Heard, J. M., 134 Hutt-Fletcher, Lindsey M., Kascsak, Richard J., 42, 3688 Gold, C., 2691 Hearing, Patrick, 543, 2555 774, 1125 Kassavetis, George A., 597 Gold, Larry, 3790 Hearl, William G., 1586 Hutton, Liz, 3625 Kato, Mieko, 2182 Goldbach, Rob, 236 Heidecker, Gisela, 3066 Hwang, Eun Seong, 465 Kato, Nobuyuki, 2182 Goldberg, J., 2891 Heilbronn, Regine, 119 Hynes, N., 1651 Kato, Shigehisa, 1861 Goldman, Robert, 3625 Heilman, Conrad J., 1532 Katz, R., 1999 Golemis, Erica, 693 Hemming, Val G., 1851 Iba, Hideo, 4012 Katze, Michael G., 16 Gonda, Matthew A., 962, 4046 Henderson, Earl E., 221 Ibanez, Carlos E., 933 Kawai, Sadaaki, 1665, 3208, Gonda, Thomas J., 2754 Henderson, Lee A., 3072 Ihle, James N., 2339 3733, 4012 Gong, Michael, 499 Henderson, Louis E., 629, 1116 Imai, Mitsunobu, 3030, 3555 Kawakami, Masaya, 2059 Goodenow, Maureen M., 2489 Hengartner, Hans, 2509 Imamura, Takayuki, 3543 Kawakita, Masao, 625 Gooding, Linda R., 928 Henrard, Denis, 3013 Inokuchi, Yoshio, 3946 Kawase, Shigemi, 553 Goodman, Howard M., 3491 Hermiston, Terry W., 3214 Inouye, Masayori, 302 Kean, K. M., 1722 Gorman, Barry M., 2304 Hermonat, Paul L., 3889 Isfort, Robert J., 2614 Keech, Bernice J., 2951 Goto, Naoaki, 3733 Hermoso, Jose M., 3983 Ishibashi, Masahide, 151 Kehrl, John H., 3441 Gowans, E., 2891 Herr, Winship, 3536 Ishimoto, Akinori, 1861 Keil, Gunther M., 526, 1901, Graessmann, A., 1821 Hertz, Gerald Z., 2322 Isom, Harriet C., 3570 2054 Graessmann, M., 1821 Herzog, Norbert K., 3625 Issel, Charles J., 1266, 2956 Keller, Beat, 113 Gralla, Jay D., 748 Hettrick, Kristine L., 2631 Isselbacher, Kurt J., 3491 Keller, Paul Malcolm, 2951 Grant, Chris K., 8, 3410 Hewlett, Martinez J., 2319 Ito, Junetsu, 594 Kelly, Thomas J., 1559 Grass, David S., 2331 Hey, Timothy D., 802, 2307 Ito, Yoshiaki, 2253 Kemble, George W., 3143 Grasser, Friedrich A., 3373 Hickling, Julian K., 3463 Iwasaki, Kentaro, 625 Kennedy, Richard C., 3235 Green, M., 1651 Highlander, Steven L., 3356 Kennedy, Ronald C., 2024, Green, Patrick L., 2192 Hilgers, J., 1651 3804 Greene, Cornelia R., 4026 Hinze, Harry C., 3580 Jackson, David C., 214 Kern, Francis G., 4055 Greene, Mark I., 3222 Hirano, Akiko, 584 Jackson, Paul, 2823 Kerwar, Somesh, 1532 Greenhouse, Jack J., 3004 Hirashima, Akikazu, 3946 Jaegle, Martine, 236 Ketner, Gary, 3759 Gregory, Timothy, 3804 Hirochika, Hirohiko, 2599 Jaenisch, Rudolf, 336, 2549, Kew, Olen M., 1442 Griffin, John W., 3431 Hirsch, Martin S., 2024 2742 Khan, Arifa S., 876 Griffith, Gary R., 375 Ho, David D., 2024 Jahn, Gerhard, 119, 1358 Khoury, George, 708, 1761, Grill, Susan P., 2947 Hoatlin, Maureen E., 1442 Jamieson, Beth D., 3920, 3930 2175 Grodzicker, Terri, 673 Holland, Gina D., 701 Jansen, Robert W., 735 Kieff, Elliott, 499, 945, 1796 Grose, Charles, 2877 Holland, John J., 200, 454 Jarvis, Donald L., 3950 Kilpatrick, David R., 4007 Grossman, Zehava, 3020 Holland, L. E., 2691 Javier, Ronald T., 1978 Kincaid, Anne L., 3431 Grubman, Marvin J., 3199 Holmes, Kathryn V., 185, Jaynes, Jesse M., 2033 King, Andrew M. Q., 2885, Grun, Janet B., 3641 1814 Jeang, Kuan-Teh, 708, 819, 3855 Grussenmeyer, Thomas, 3902 Holmgren-Konig, Monika, 1559, 1761, 2175 King, Chwan-Chuen, 1571 Guarino, Linda A., 2091 1761 Jenkins, Frank J., 992 King, Norval W., 1421 Guggenheimer, R. A., 851 Holmsen, Holm, 3388 Jenkins, Nancy A., 2929 King, Steven R., 701 Guhl, E., 1821 Holtzman, Douglas, 2754 Jennings, Stephen R., 104 Kiyotaki; Masaya, 1421 Guhr, Barbara, 2280 Homcy, Charles J., 1834 Jense, Holly G., 2480 Klages, Sabine, 446 Gurney, Theodore, Jr., 764 Honess, Robert W., 2063 Jenson, Hal B., 1495, 3672 Klein, Christine, 1552 Gutierrez, Julio, 3983 Hope, R. G., 2428 Jessberger, Rolf, 344 Klein, George, 3870 Hopkins, Nancy, 693 Joab, Irene, 3340 Klein, Hilton J., 2951 Haarr, Lars, 2428, 3388 Horak, Ivan, 2071 Johnson, David C., 2208, Kloetzer, William, 8 Hackett, Charles J., 1375 Horowitz, Jonathan M., 701 2438, 3356 Knipe, David M., 276, 615 Hadlow, William J., 3235 Horswood, Robert L., 1851, Johnson, Eugene M., Jr., 2311 Kobayashi, Hiroshige, 1808 Hagino-Yamagishi, Kimiko, 4019 Johnson, Philip R., Jr., 3163 Kobayashi, Midori, 1808 1964 Horwitz, Bruce H., 1248 Johnston, Margaret I., 1586 Koch, Tamar, 972 Hahn, Beatrice H., 570 Horwitz, Marshall S., 3665 Jolicoeur, Paul, 3266 Koener, Josette F., 1342 Haller, Aurelia A., 3470 Hoshi, Yuji, 3555 Joncas, J. H., 3306 Koenig, Scott, 209 Halpern, Michael S., 722, 916 Houghten, Richard A., 8 Jones, Elaine V., 1765 Koff, Andrew, 2143 Hampson, Alan W., 214 Hou-Jong, Mei-Huei Jessie, Jones, Katherine H., 3635 Koike, Katsuro, 1808 Hanafusa, Hidesaburo, 354, 937 Jorgensen, Ellen D., 1473 Kolakofsky, Daniel, 87, 96, 1678 Hovi, Tapani, 3749 Jove, Richard, 354, 1678 667, 3960 Hanafusa, Teruko, 1678 Howett, Mary K., 590 Jurdic, P., 3058 Konrad, Michael, 2120 Happ, Brigitte, 3048 Howley, Peter M., 962, 1630, Justewicz, D., 2050 Korba, Brent E., 1318 Hare, J. Donald, 516 2128, 3889 Kosowski, Steve G., 3617 Harley, Eric H., 1747 Hruby, Dennis E., 639, 1398 Kabacoff, Cathryn M., 1919 Koszinowski, Ulrich H., 526, Harmison, George G., 3133 Hsu, Tien, 366 Kabat, David, 2782 1901, 2054, 3102 Hart, Paul B., 2989 Hu, Shiu-Lok, 3617, 3804 Kaehler, Donal A., 2192 Kouzarides, Tony, 125, 1358 Hartley, Janet W., 693, 2109, Huang, Henry V., 3809 Kaerner, H. C., 600 Kowalski, Edward, 3345 2225 Hubenthal-Voss, Jeff, 3349 Kakimi, Kizuhiro, 1861 Koyama, Takumi, 3208 Haseltine, William A., 269, Hudson, James B., 3602 Kakuyama, Masahiro, 1861 Kozak, Christine A., 218, 633 Hughes, J. L., 683 Kallin, Bengt, 3870 1164, 1651, 2225, 3082 Hassell, John A., 1226 Hughes, Robert G., Jr., 2989 Kamech, Nedia, 1546 Krausslich, Hans G., 2711 Hayes, Shirley J., 3499 Hughes, Stephen H., 3004 Kanda. Tadahito, 625 Kreider, John W., 590 Hayes, Stanley F., 1037 Huismans, Hendrik, 3589 Kannagi, Mari, 1421 Krell, Peter J., 3655 Hayward, Gary S., 190, 819, Humphrey, G. W., 2336 Kantoff, Philip W., 1647 Krochmalnic, Gabriela, 1007 1559 Hundley, Fiona, 3365 Kaplan, Albert S., 796, 4030 Kroger, Burkhard, 2071 Hayward, William S., 1203, Hunter, Eric, 1045, 1276, Kaplan, David, 1221 Krug, Robert M., 16, 361, 764 2489 1609, 2981 Kaplan, Paul L., 1731 Kruppa, Gracia, 2567 iv AUTHOR INDEX J. VIROL.

Ktistakis, Nicholas T., 2621 Levine, Myron, 2691, 3356 Mager, Dixie L., 4060 Mertz, Janet E., 2322, 3190 Kuff, Edward L., 3020 Levis, Robin, 3809 Mainprize, Terry H., 661 Merz, Patricia A., 42, 3688 Kuge, Shusuke, 1478 Levy, David E., 1261 Major, Eugene O., 1435 Mester, J., 1073 Kuhn, Andreas, 113 Levy, Jay A., 3804 Malik, Frank G., 1882 Mettenleiter, Thomas C., Kuhn, Christa, 2280 Levy, Laura S., 743, 3072 Mallon, Robert G., 1655 2764, 4030 Kumar, Harish P. M., 3410 Lewis, Andrew M., Jr., 2155, Malone, Cheryl L., 3214 Metzger, D. W., 2910 Kumar, Rakesh, 1524, 2727 2924, 3510 Mandel, Gail, 2232 Michalak, Susan, 3345 Kung, Hsing-Jien, 2084, 2614 Lewis, James B., 247, 3879 Mandl, Christian, 755 Michalides, R., 1651 Kuo, Tsong-Teh, 60, 1695 Lewis, T. L., 3820 Maniloff, Jack, 1909 Michalovitz, Dan, 2648 Kurath, Gael, 1342 Li, Chou-Chi H., 2684 Manischewitz, Jody F., 1875 Mietz, Judy A., 3020 Kurth, R., 2017 Li, Jing-Po, 2782 Manley, James L., 2331 Milich, D. R., 683 Kurtzman, Gary, 2395 Li, Jin-Sen, 2947 Mann, Karen P., 2100 Miller, A. Dusty, 1639 Kusari, Jyotirmoy, 1524, 2727 Li, Yen, 693 Mann, Kristine, 3373 Miller, Beverly W., 3630 Kusuda, Jun, 553 Liao, You-De, 1695 Marchioli, Carmine C., 229, Miller, D., 2029 Kwok, Shirley, 1690 Lichtenberg, Ursula, 2719 3977 Miller, George, 1495, 1602, Lien, Jau-Min, 3832 Marion, Patricia L., 2273, 3672 Lackner, Andrew A., 3066 Lillehaug, Johan R., 3388 3241 Miller, Lois K., 661, 1712, La Colla, Paolo, 561 Lin, Bi-Yu, 60 Markland, William, 285 2264 Lai, Ching-Juh, 4019 Lin, Jung-Chung, 607, 1985 Marks, J., 2029 Millward, Stewart, 2472 Lai, Michael M. C., 3968 Lin, Yu-Hwei, 60 Marongiu, Maria E., 561 Milman, Gregory, 465 Laigret, Frederic, 876 Lindemeyer, Rochelle G., 221 Marriott, Susan J., 375, 2747 Miyajima, Nobuyuki, 4012 Laimins, Laimonis A., 3635 Lindgren, Valerie, 962 Marsden, H. S., 2428 Miyakawa, Yuzo, 3030, 3555 Lairmore, Michael D., 4038 Linial, Maxine, 1949, 2138 Martin, Kelsey, 1602 Miyanohara, Atsushi, 3543 La Mantia, Girolama, 1296 Linney, Elwood, 3248 Martin, Malcolm A., 209, 2109 Moberg, L., 2017 Lamb, Robert A., 1972 Lippe, Patricia A., 104 Martin, Stephen, 726 Mocarski, Edward S., 3143 Lambert, Paul F., 2128 Lipsick, Joseph S., 933, 3284 Martinez-Salas, Encarnaci6n, Mockli, Gary, 308 Lamm, Michael E., 2624 Lipton, Howard L., 1507 233 Modrow, Susanne, 570 La Monica, Nicola, 2917 Lirette, Ron, 3040 Maruyama, Takeo, 553 Mohamad, Adel, 1108 Lang, Dimitrij, 2621 Liu, Li-Fan, 60 Marx, Maria, 2523, 2530 Mohr, Ian J., 3326 Langeland, Nina, 3388 Livingston, Charles W., Jr., Marx, Preston A., 3066 Mold, Carolyn, 1416 Langelier, Y., 2046 1086 Masiarz, Frank, 315 Molineaux, Susan, 1325 Langer, Stephen J., 2885 Ljungman, P., 2017 Mason, William S., 916, 2891, Montalvo, Eduardo A., 2877 Lania, Luigi, 1296 Lloyd, Richard E., 2480 3832 Montelaro, Ronald C., 1266, Lapidot, Moshe, 2245 Lobelle-Rich, Patricia A., Mathieu, Florence, 2448 2956 Larsen, Steven H., 937 3072 Matsubara, Kenichi, 3543, Montenarh, Mathias, 940 Larsson, Erik, 2182 Lodmell, Donald L., 3314 3555, 3848 Mooney, Duane T., 2828 Lasky, Laurence A., 726, Loeb, David M., 2420 Matsui, Takane, 3555 Moore, Douglas M., 3199 1532, 3804 Lokensgard, J. R., 3820 Matsuo, Takumi, 499 Moore, R., 480 La Torre, Jose L., 419 Lomniczi, Bela, 796, 1772, Matsuyama, Koji, 1808 Moran, Patricia A., 3804 Laugier, Danielle, 1678, 2523, 4030 Matsuyama, Mutsushi, 1861 Morein, Bror, 3896 2530 Londo, David R., 2217 Mattaliano, Robert J., 2280 Moreno-L6pez, Jorge, 2240, Laver, W. G., 2910 London, William T., 1435, Matthews, Betty-Jean, 1282 3394 Lavery, Dan, 1466 2857 Matz, Bertfried, 1427 Morfeldt-Mansson, L., 2017 Lawrence, William C., 4023 Long, Walter K., 221 May, Dana L., 3510 Morgan, Andrew, 1796 Lazaro, Jose M., 3983 Longnecker, Richard M., 2896 May, Evelyne, 167 Morishima, Tsuneo, 1808 Lazo, Pedro A., 2038 L6pez, Rubens, 2573 Mayer, Bruce J., 354 Morita, Kouichi, 256 Lazzarini, Robert A., 1332 Lorch, Yahli, 898 Mayfield, J. E., 3827 Morita, Yasuyuki, 1726 Leader, David P., 2896 Lord, Carol I., 1421 Mayumi, Makoto, 3030, 3555 Morrey, John D., 1350 Lecomte, J., 2050 Lorenzen, Susan K., 177 Mazanec, Mary B., 2624 Morris, V., 1651 Lederman, L., 1193 Lorimer, Heather E., 1712 McAleer, William J., 2951 Morse, Herbert C., III, 383 Lederman, Muriel, 3612 Love, Arthur, 3896 McAtee, Frank J., 1037 Morton, David H., 2951 LeDuc, James W., 735 Lowe, Robert S., 2951 McCarley, Deborah J., 1927 Mosca, Joseph D., 819, 1253 Lee, Chue-Shue, 3491 Lowenstine, Linda J., 3066 McChesney, Michael B., 3441 Mose Larsen, Peter, 3596 Lee, Inchul, 3013 Loyter, Abraham, 2245 McClure, Harold M., 4026 Moskophidis, D., 1867 Lehmann-Grube, F., 1867 Lozano, G., 2029 McClure, Jan, 3804 Moss, Bernard, 75, 516, 726, Leis, Jonathan, 534, 1999 Lubinski, John M., 2997 McConnell, Stewart, 1086 1098, 1286, 1738, 1765, 1972 Lemay, Guy, 2472 Ludlow, John W., 509, 1708, McCormick, A. Louise, 3143 Mowat, Michael, 2777 Lemieux, Real, 2472 2934 McFadden, Grant, 1271, 1957 Mucenski, Michael L., 2929 Lemon, Stanley M., 491, 735 Ludwig, G. V., 3292 McGee, Juli S., 8 Mulder, Carel, 3485 Lenard, John, 256 Lueders, Kira K., 3020 McGlade, C. Jane, 3227 Muller, Mark T., 858, 2428 Lenny, Albert B., 1796 Lufkin, Tom, 1466 McGowan, John J., 1814 Muller, Thomas, 3048 Lenz, Jack, 1067 Lycke, Erik, 2733 McIntyre, Martin, 3365 Muller, Ulrich, 3710 Leonard, John, 3726 Lyles, Douglas S., 1992 McKinnon, Randall D., 1261 Mulligan, Richard, 2549 Leong, JoAnn, 1342 Lynde-Maas, Mary Kay, 621 McKnight, Jennifer L. C., 992 Mullis, Kary B., 1690 Lerche, Nicholas W., 3066 McLachlan, Alan, 683 Munch, Konrad, 3102 Letchworth, G. J., III, 3292 Maa, Juehn-Shin, 3910 McMahon, S., 722 Munshi, Sonal, 1796 Letvin, Norman L., 1421 Macen, Joanne L., 1271 Medveczky, Peter, 3485 Munson, Melinda, 8 Leung, Kiu, 3331, 4033 Mach, M., 1358 Meier, Ellen, 3133 Murotsu, Tomoaki, 3848 Leure-Dupree, Alphonse E., Mack, David H., 1690 Melancon, Paul, 1301 Murphy, Brian R., 1473, 1972, 590 Madden, Mary J., 646 Mellado, Rafael P., 1751 2857, 3163, 3416 Levesque, Peter, 3521 Maeder, Marlies, 113 Merigan, Thomas C., 1532, Murphy, Edwin C., Jr., 2378 Levine, A. J., 2029 Maeno, Koichiro, 388 2120 Murphy, M., 2428 Levine, Arthur S., 1282 Magar, R., 2050 Mertz, Gregory J., 264 Mutter, Wolfgang, 3102 VOL. 61, 1987 AUTHOR INDEX v

Nagaya, Tsutomu, 3848 Ono, Kenzo, 1332 Peters, G., 480, 1651 Raju, Ramaswamy, 87, 96, Nagy, Eva, 3655 Ono, Masao, 2059 Peters, Nick, 3322 667 Najarian, Richard, 326 Ono, Yasushi, 3310 Peterson, D., 1651 Ramig, Robert F., 1086 Nakamura, Takaaki, 3848 Ooka, Tadamasa, 499 Petit, Robert G., 3331, 4033 Raney, A. K., 683 Nakano, Eileen T., 302 Orberg, Paulo K., 1136, 3528 Petitjean, Anne Maria, 1391 Rangel, Luz Maria, 1002 Nakao, Junji, 3543 O'Reilly, David R., 167 Petrie, Betty L., 1488 Ransone, Lynn J., 1781, 2997 Nara, Peter L., 3173 Oren, Moshe, 2648 Petropoulos, Christos J., 3004 Rao, Madan M., 302 Narayan, Opendra, 1019, 3431 Oroskar, Asha A., 604 Petrovskis, Erik A., 3977 Rapp, Ulf R., 2339 Narindrasorasak, S., 3795 Oroszlan, Stephen, 629, 1116 Pettersson, Ulf, 2240, 3394 Rasmussen, Jennifer A., 1368 Nasseri, Mahammad, 2581 Orth, Gerard, 3295 Petti, Lisa, 945 Rassart, Eric, 3266 Natarajan, Venkatachala, 646 Osborn, Kent G., 3066 Pevear, Daniel C., 1507 Rattray, Alison J., 2843 Nathans, Daniel, 436 Osburn, Bennie I., 2670 Pfaff, Eberhard, 904 Rawlins, Dan R., 1559 Nauman, Suzanne M., 1266 O'Shaughnessy, Joyce, 3299 Pfeifer-Ohlsson, Susan, 2182 Ray, Anuradha, 3999 Nayak, Debi P., 2217 Ostermayr, Richard, 3645 Pfitzner, Artur J., 2902, 2943 Ray, Jasodhara, 3381 Neary, Kathryn, 1248 Ostertag, Wolfram, 889, 2742 Pfizenmaier, Klaus, 2567 Ray, Prabir, 3999 Neckameyer, Wendi S., 1203 Ostrove, Jeffrey M., 225, 3726 Phelps, Andre H., 2951 Read, G. Sullivan, 604 Nedrud, John G., 2624 Ou, Jing-hsiung, 782 Phelps, William C., 962, 1630 Reddehase, Matthias J., 2054, Neidhardt, H., 600 Ozawa, Keiya, 2395, 2627 Piche, Alain, 840, 845 3102 Neill, Suzanne D., 3248 Pickett, Siobhan, 308 Reddy, Sita, 1079 Nelson, Jay A., 2639 Pachl, Carol, 315, 326 Pigiet, V., 2336 Reeve, John N., 3254 Nemerow, Glen R., 1416 Pacitti, Anne F., 1407 Pipas, James M., 2648 Reik, Wolf, 336 Nerenberg, Michael, 708 Paez, Eduardo, 395, 2642 Pirisi, Lucia, 1061 Reilly, Sheila S., 1913 Nesburn, Anthony B., 3820 Pagano, Joseph S., 607, 3769 Pitha, Paula M., 819 Reiser, Walter, 904 Nguyen, H., 1193 Pal, Ranajit, 239 Plachter, B., 1358 Remeneck, James, 1814 Nibert, Max L., 1834, 2351 Palmenberg, Ann C., 2033, Poddar, Saibal K., 1909 Renz, Mark E., 1442 Nichol, Stuart T., 200, 1029 3680 Poiesz, Bernard, 1690 Repaske, Roy, 2225 Nickerson, Jeffrey A., 1007 Palmer, Theo D., 1639 Poirier, Franqoise, 2523, 2530 Rhee, Sung S., 1045 Nicklin, Martin J. H., 2711 Palmieri, Steven, 1717 Poirier, Yves, 3266 Rhode, Brett W., 925 Nicolaisen-Strouss, Kathryn, Pan, Yu-Ching E., 534 Pollack, Robert E., 3521 Rhode, Solon L., III, 1448, 3410 Panet, Amos, 1756 Polvino-Bodnar, Maryellen, 2807 Nicolas, Jean-Claude, 3340 Pani, Alessandra, 561 3528 Rice, Charles M., 3809 Nikoletti, Suzanne, 3602 Pannuti, Antonio, 1296 Pomert, Eric, 3521 Rice, Nancy R., 743, 1577 Nishina, Hiroshi, 4012 Pantaloni, Dominique, 1546 Poonian, Mohindar S., 534 Rice, Stephen A., 276 Nishiyama, Yukihiro, 388 Pao, Anna, 2823, 2835 Popescu, Nicholas C., 1682 Rice, William C., 1712 Nishizawa, Makoto, 1665, Paradis, H., 2046 Porter, David D., 3920 Richard, Sandra M., 2807 3208, 3733, 4012 Parce, J. Wallace, 1992 Portis, John L., 29, 1037 Richards, Oliver C., 802, 2307 Noda, Tetsuo, 2253 Pare, Nicola, 1747 Post, Leonard E., 229, 3977 Rickinson, Alan B., 1310 Nomoto, Akio, 1478, 2816 Parekh, B. S., 982 Poumbourios, Pantelis, 214 Ridgway, A., 2084 Norbury, Christopher J., 3754 Park, In-woo, 2033 Prakash, O., 1651 Riepenhoff-Talty, Marie, 3345 Norrby, Erling, 3896 Parker, Michael L., 2828 Prasad, B. V. Venkataram, Riggs, M. G., 683 Norton, Pamela A., 1171 Parks, Griffith D., 3680 2319 Riggs, Paul D., 2316, 3621 Notkins, Abner Louis, 1700 Parma, David, 3790 Prasad, Vinayaka, 2038 Rima, Bert K., 472 Nottenburg, Carol, 1828 Parris, D. S., 2428 Praszkier, J., 3089 Ringuette, Maurice, 2297 Nussbaum, Ofer, 2245 Parsons, J. Thomas, 1927, Preddie, E., 1358 Risser, Rex, 701, 2192, 2852 Nusse, R., 1073, 1651 2138 Preston, C. M., 2428 Robbins, Alan K., 2691, 2962 Parsons, Ramon, 2143 Prestridge, Dan S., 3248 Robert-Lezenes, Jacqueline, Oba, Douglas E., 1125 Parsons, Sarah J., 1927 Price, Mary A., 912 579 Oberst, Richard D., 2670 Pascucci, Anna, 1296 Price, Patricia, 3602 Roberts, Thomas M., 1213, O'Boyle, Donald R., II, 3288 Passavant, C. W., 1342 Price, Peter M., 1108, 2921 1221 O'Connell, Anna P., 916 Pastan, Ira, 883 Prieto, Ignacio, 3983 Robey, William G., 629, 3173 Oellig, Cornelia, 3048 Paterson, Reay G., 1972 Prince, Gregory A., 1851, Robinson, H. L., 1164, 3114 Ogiu, Toshiaki, 1861 Patick, Amy K., 3580 3163, 3416, 4019 Robinson, William S., 2273 Ogra, Pearay L., 3345 Patterson, Jean, 87 Privalsky, Martin L., 1938 Rock, D. L., 3820, 3827 Ogura, Hisashi, 472 Patton, John T., 3479 Prives, Carol, 1712 Rodi, Charles P., 876 Oguro, Mieko O., 3310 Pauley, R., 1651 Provost, Philip J., 2951 Rodriguez, Jose F., 395, 3550 O'Hare, Peter, 190 Pauza, Kevin J., 104 Prusiner, Stanley B., 159 Roebroek, Anton J. M., 2009 Ohlsson, Rolf, 2182 Payne, Susan L., 1266 Puckett, Carmie, 1765 Roeder, Daniel J., 2747 Ohtomo, Nobuya, 3543 Pearson, Mark L., 3254 Puga, Alvaro, 1700 Rogers, Diane B., 1814 Okamoto, Hiroaki, 3030, 3555 Peden, Keith W. C., 436 Pugh, John C., 1384 Rohdewohld, Heidemarie, 336 Okenquist, Sharon A., 1067 Pellett, Phillip E., 992 Purcell, Robert H., 50, 3035 Roivainen, Merja, 3749 Oldstone, Michael B. A., 982, Penaranda, Maria E., 1488 Purves, Frances C., 2896 Roizman, Bernard, 992, 2896, 1571, 2639, 3441 Penciolelli, Jean Franqois, 579 Pusztai, Rozalia, 2326 3349 Olkkonen, Vesa M., 2362 Penman, Sheldon, 1007 Roman, Ann, 937 Olmsted, Robert A., 3163, Pereira, Lenore, 104, 3143 Quinlan, Margaret P., 673 Ronda, Concepci6n, 2573 3416 Perez, Lautaro G., 1276, 1609, Quinnan, Gerald V., Jr., 1875, Roossinck, Marilyn J., 955 Olsen, John C., 2800 2981 2150 Rose, John K., 2042 Omata, Toshiko, 625 Perrault, Jacques, 3470 Roseman, Nancy A., 1398 Omilli, Francis, 167 Perricaudet, Michel, 3120, Raab-Traub, Nancy, 607, Rosen, Anders, 3870 O'Neill, Allison Eastman, 928 3340, 3424 1552, 1985 Rosen, Craig A., 633 O'Neill, Raymond R., 2109, Persing, David H., 1672 Rabson, Arnold B., 3726 Rosenblum, Betsy, 3035 2225, 3082 Person, Stanley, 714 Racaniello, Vincent R., 2917 Rosenfeld, Philip J., 1559 Ong, John, 3820 Perucho, Manuel, 302 Race, Richard E., 2407, 3235 Rosenthal, K. L., 2438 Onnekink, Carla, 2009 Petcu, David J., 3832 Raj, N. B. K., 1253 Ross, Rachel, 3227 vi AUTHOR INDEX J. VIROL.

Ross, Susan R., 3013 Scodeller, Eduardo A., 419 Sninsky, John J., 1384, 1690 Summers, Max D., 361, 1488, Rossitto, Paul, 308 Seeger, Christoph, 3241 Snyder, H. W., 1193 2091, 2589 Rota, Teresa R., 2024 Seibl, Rudi, 3672 Snyder, Mark H., 2857 Summers, Peter, 4019 Rottier, Peter J. M., 2042 Seidler, Chris, 2631 Sobieszczuk, Peter, 2754 Summers, William C., 1291 Rouse, Barry T., 726 Seif, Roland, 1546 Sodroski, Joseph G., 633 Sutherland, Sharon L., 3356 Rowe, David T., 3340 Seliger, Barbara, 2567 Soe, Lisa H., 3968 Sutrave, Pramod, 3004 Rowe, Martin, 1310, 3870 Sells, Mary Ann, 1108, 2921 Sola, Brigitte, 4043 Swanstrom, Ronald, 2800 Rozhon, Edward, 1507 Semler, Bert L., 2162, 3181 Soltis, Daniel A., 534 Swenson, R. Brent, 4026 Rubenstein, Richard, 42, 3688 Sen, Ganes C., 653, 1524, Somasundaran, M., 3114 Swift, R. A., 2084 Rubin, Donald H., 3222 2727 Sonenberg, Nahum, 986 Szomolanyi, Eva, 3485 Rubinstein, Riva, 1747 Senechek, David, 276 Sonnerborg, A., 2017 Ruger, Barbara, 446 Serwer, Philip, 3499 Sorge, J., 683 Tagawa, Masami, 2273 Rundell, Kathleen, 1240 Seth, Arun, 2684 South, S., 2438 Taichman, Lorne B., 1913 Runzler, Robert, 2076 Seth, Prem, 883 Southern, P. J., 982 Taira, Hideharu, 625 Ruscetti, Sandra K., 1661, Seung, Steven, 945 Sowder, Raymond C., 629, Takada, Kenzo, 3310 2109 Sever, John L., 1435 1116 Takeda, Naokazu, 2816 Russell, Helena I., 4038 Sevoian, Martin, 3783 Spalholz, Barbara A., 2128 Takimoto, Masato, 1861 Rutledge, R. A., 2109 Shah, Keerti V., 2684 Spear, Patricia G., 1, 104 Talmon, Yeshayahu, 2319 Rutter, William J., 782 Shalloway, David, 1079 Speck, Samuel H., 2902, 2943 Tambourin, Pierre E., 579, Rwambo, Paul M., 2956 Shanley, John D., 23 Spencer, John H., 2297, 3694 4043 Ryan, J. Patrick, 2962 Shapiro, Geoffrey 1., 764 Spiro, Craig, 2782 Tan, Run-Sheng, 2947 Rydnert, Jan, 2182 Sharp, Phillip A., 1213 Spivack, Jordan G., 3288, Tanaka, Takeshi, 3030 Shaul, Yosef, 1180 3841 Taniguchi, Koki, 1726 Sacks, Wendy R., 829 Shaw, George M., 570 Sprecher, E., 2515 Taylor, Benjamin A., 2929 Sagedahl, Adrian, 419 Shaw, James E., 3331, 4033 Sprengel, Rolf, 904, 3322 Taylor, G., 3855 Sakai, Koji, 3774 Shaw, Jocelyn E., 3254 Spriggs, Melanie K., 3416 Taylor, J., 2891 Salas, Margarita, 1751, 3983 Shellam, Geoffrey R., 3602 Srinivas, Ranga V., 4007 Tegtmeyer, Peter, 2143, 3649 Salfeld, Jochen, 3109, 3701 Shenk, Thomas, 543, 2555, Srinivasan, A., 4026 Temin, Howard M., 925, Salinovich, Olivia, 1266 3096 Stacey, Alex, 889, 2549 2675, 3454 Salzman, Norman P., 646 Shen-Ong, Grace L. C., 3721 Stacy-Phipps, Sandrina, 3479 Tennant, Bud C., 1318 Samal, Siba K., 1086 Shero, James H., 1559 Stahl, Hans, 411 Tenser, Richard B., 2171 Samarut, J., 3058 Shibuta, Hiroshi, 625 Stamatos, Nicholas M., 516 Teramoto, Yoshio A., 2607, Samulski, Richard Jude, 2555, Shieh, Chien-Kou, 3968 Stamminger, Thomas, 2063 2655 3096 Shiga, Kiyoshi, 3848 St. Angelo, Carol, 16, 361 ter Meulen, Volker, 472 Sanchez-Pescador, Lisa, 315 Shih, Chao-yun T., 912 Stanley, Jeff, 1019 Terry, R., 1999 Sanwal, B. D., 3795 Shih, Chiaho, 3491 Stapleton, Jack T., 491 Tevethia, Satvir S., 104 Sarkar, N., 1651 Shih, Ding S., 912, 2033 Starr, Lisa, 3349 Teyssedou, E., 2050 Sarngadharan, M. G., 2024 Shimada,Takashi, 2395 Steffen, D. L., 1164 Theilmann, David A., 2589 Satake, Masanobu, 2253 Shimizu, Norio, 3310 Steinman, Lawrence, 898 Theodore, T. S., 2109 Satchwell, Sandra C., 125 Shinedling, Sidney, 3790 Stenlund, Arne, 2240 Thierry, F., 134 Satchwell, S. C., 1358 Shirasawa, Hiroshi, 2389 Stephens, Robert M., 743, Thompson, Richard L., 1978 Sato, Vicki L., 2024 Shiroki, Kazuko, 2326 1577 Thompson, Sandra, 2076 Savard, Pierre, 3266 Short, Mary K., 1067 Stevens, Jack G., 1978 Thomsen, Darrell R., 229 Sawutz, David G., 1834 Showalter, Stephen D., 1577 Stevenson, Mario, 3741, 3774 Thorley-Lawson, David, 2100 Scalzo, Anthony A., 214 Shvartsman, Marina, 2921 Stillman, Bruce, 426 Ticehurst, John R., 50, 3035 Schaaf, Karen F., 3617 Sicard, A. M., 1540 Stinski, Mark F., 3214 Tierney, Eveline L., 2857 Schaeffer, Eric, 1384 Siddiqui, Aleem, 955 Stockard, Joe, 2828 Timmins, James G., 3977 Schaffer, Priscilla A., 829, Silberklang, Melvin, 1796 Stocking, Carol, 889 Tiwari, Raj K., 1524, 2727 1092, 1136, 3528 Silverstein, Saul, 2286, 3167 Stoltzfus, C. Martin, 177, 921, Tobin, Gregory J., 611 Schaffhausen, Brian, 1147, Silverstone, A., 1193 3401 Tokino, Takashi, 3848 1155, 1213, 1221 Simek, Stephanie L., 1577 Storgaard, Lene, 3596 Tollefson, Vanessa, 1416 Schalken, Jack A., 2009 Simizu, Bunsiti, 2389 Stott, E. James, 293, 2885, Tomita, Yoshimi, 2389 Schaller, Heinz, 904, 2280, 3701 Simon, M. Celeste, 1203 3855 Tomlinson, Peter, 125, 446 Scheidtmann, Karl Heinz, Simon, Suzanne, 1731 Stott, Jeffrey L., 2670 Tonna-DeMasi, Maria, 3688 940, 3902 Singh, Balraj, 3625 Stout, Ernest R., 3612 Torelli, Silvia, 561 Scherneck, Siegfried, 3992 Sissons, J. G. Patrick, 3463 Stoye, Jonathan P., 2659 Torseth, John W., 1532 Schickedanz, Jorg, 2054 Skalka, Anna Marie, 534, Straus, Stephen E., 225 Toth, Miklos I., 2326 Schirmbeck, Reinhold, 3561 1999 Strauss, James H., 3809 Toyoda, Haruka, 2711, 2816 Schlegel, Richard, 2924 Skehel, J. J., 206 Strauss, Michael, 3326 Toyoshima, Kumao, 1665 Schlicht, Hans J., 2280, 3701 Sluyser, M., 1073 Strohmaier, K., 1621 Traktman, Paula, 3152 Schloemer, Robert H., 3448 Smibert, Craig, 2368 Strom, Ted, 2198 Traub, Franz, 113 Schmitt, Robert C., 247 Smiley, James R., 2368, 2438 Strominger, Jack L., 2902, Traub, Renee G., 1435 Schneider-Maunoury, Sylvie, Smith, Alan E., 285 2943 Traupe, B., 1358 3295 Smith, Colton A., 1092 Stubblefield, Elton, 1828 Trautwetter, A., 1540 Schnorr, Kenneth L., 2956 Smith, Gale E., 361, 1488 Sturzenbecker, Laurie J., 2351 Tremblay, Michel L., 3227 Scholl, B.-C., 1358 Smith, G. L., 1098 Stuve, Laura L., 315, 326 Tsai, Eugene C., 2902 Schooley, Robert T., 2024 Smith, Janet L., 276 Su, Henry K., 1735 Tsiang, Henri, 2733 Schreurs, Christa, 2764 Smith, Marilyn S., 3769 Su, Lishan, 615 Tsichlis, Philip N., 2038 Schroder, C. H., 600 Smith, M. Carolyn, 607 Subramanian, Kiranur N., Tsuda, Fumio, 3030 Schubert, Manfred, 1332, 3133 Smith, R., 480 2973 Tsui, Shanli, 2143 Schulz, Manfred, 344 Smith, Ralph E., 1203 Sugden, Bill, 866 Tsurimoto, Toshiki, 3555 Schwend, Virginia Keivens, Smotkin, David, 1686 Summers, Jesse W., 1384, Tsurumi, Tatsuya, 388 1416 Smythers, G. W., 1116 2891 Tu, Jenn, 1695 VOL. 61, 1987 AUTHOR INDEX vii

Turek, Lubomir P., 3401 Waldmann, H., 1867 Whealy, Mary E., 2691, 2962 Yakobson, Bracha, 972 Twu, Jr-Shin, 3448 Walker, Duard L., 755 Whitbeck, J. Charles, 4023 Yamaguchi, Yuko, 2253 Walker, Thomas A., 3510 White, David O., 214 Yamamoto, Tadashi, 1665 Umene, Kenichi, 1187 Walla, Birgitt, 446 White, Eileen, 426 Yancey, Robert J., Jr., 229, Underwood, P. Anne, 206 Walsh, Edward E., 3163 Whitfeld, Peter L., 1054 3977 Upton, Chris, 1271 Walter, Gernot, 405, 3373, Wiekowski, Maria, 411 Yang, Chen-Fu, 2816 Urasawa, Shozo, 1726 3902 Wilcox, Christine L., 2311 Yang, Czau-Siung, 3491 Urasawa, Tomoko, 1726 Wands, Jack R., 3491 Wiley, D. C., 206 Yaniv, M., 134 Ushikubo, Himomi, 2059 Wang, Fred, 945 Will, Hans, 904, 3109 Yasue, Hiroshi, 151 Wang, Guo-Ji, 2319 Williams, Jim, 3630 Yasumoto, Shigeru, 1061 Vacante, Dominick A., 1435 Warner, Susan C., 714 Williams, Kelly P., 597 Ye, Zhiping, 239 Vaidya, A., 1651 Watanabe, Shozo, 796 Willingham, Mark C., 883 Yeargan, Michelle R., 2454 Vakharia, Vikram N., 3199 Wathen, M. W., 2691 Wills, John W., 1276 Yee, Carole L., 2128 Valsamakis, Alexandra, 3441 Watson, Joseph B., 748 Wilson, Marijo E., 661 Yee, Siu-Pok, 3227 van der Horst, Charles M., Watson, R. J., 2691 Wilson, Michael C., 1261 Yetter, Robert A., 383 607 Watson, Robert H., 3499 Wilson, Van G., 2344 Yewdell, Jonathan W., 1098 Vanderoef, Roger, 256 Weber, Janet A., 590 Wimmer, Eckard, 2711, 2816 Yonemura, Hiroshi, 3543 Van de Ven, Wim J. M., 2009 Webster, Robert G., 1517, Winnacker, Ernst L., 3645 Yosida, Tosihide H., 151 van Dijk, Alberdina A., 3589 2910 Winocour, Ernest, 972 Young, Dorothy C., 611 Van Dyke, T. A., 2029 Wechsler, Steven L., 3820 Winter, Christine C., 1473 Young, Karen K.-Y., 293, Van Nest, Gary, 315 Weck, Karen E., 3726 Winter, Jillean G., 3602 2885, 3855 van Wyke Coelingh, Kathleen Weed, S. D., 2691 Wishart, William L., 2555 Young, Lawrence S., 1310 L., 1473 Wei, Rongxuan, 366 Wisniewski, Henryk M., 42, Young, Michael R., 2322 Varghese, J. N., 2910 Weiher, Hans, 336, 2742 3688 Young, Neal, 2395, 2627 Varmus, Harold E., 35, 1651, Weijer, Wicher J., 3607 Witte, Pamela R., 3214 Ypma-Wong, Mary Frances, 1672, 1828, 1964, 3241, 3322 Weimer, Thomas, 904, 3109 Witzleben, Cam L., 3222 3181 Varsanyi, Tamas M., 3896 Weinberg, Adriana, 2120 Wojciechowicz, Donald, 1655 Yu, Sheau-Fung, 1647 Vayda, Michael E., 3335 Weinrich, Scott L., 639 Wold, William S. M., 3938 Yu-Shu, Hao, 2395 Velicer, Leland F., 2614 Weinstein, Yacob, 2339 Wolf, Hans, 570, 3672 Verstraeten, A., 1651 Weir, Jerry P., 75 Wolff, Axel V., 3173 Zaino, Richard J., 590 Vesco, Cesare, 940, 1296, Weismiller, David G., 185 Wolff, Linda, 1661, 3721 Zarling, Joyce M., 3804 2648 Welch, Renee C., 3190 Wolfinbarger, James, 2407 Zeldis, Jerome B., 3491 Vijaya, S., 1164 Welch, William J., 405 Wolinsky, Steven M., 2581 Zelent, Arthur Z., 1108, 2921 Vogel, Frank, 3992 Welling, Gjalt W., 3607 Wong, Timothy C., 584 Zhang, XinHua, 3741 Vogel, Mari L., 1717 Welling-Wester, Sytske, 3607 Wong-Staal, Flossie, 570 Zhang, Yu-Lian, 2924 Vogel, Stefanie N., 812 Wellink, Joan, 236 Wood, David, 3365 Zhao, Bangti, 4019 Volsky, David J., 3741, 3774 Wells, Frances, 1318 Wooddell, M. K., 982 Zheng-Da, Shen, 621 von der Helm, Klaus, 3645 Wendling, Frangoise, 579 Woodworth, Craig D., 3570 Zhonghe, Zhai, 1007 von Ruden, Thomas, 1647 Werner, A., 2017 Woolford, Joseph, 2420 Zhou, Bing-sen, 2947 Wertz, Gail W., 293, 2885, Worrad, Diane, 3040 Zhou, Jianhui, 714 Wade-Glass, Marta, 2924 3855 Wu, Brian, 221 Zinkernagel, Rolf M., 2509 Wagenaar, E., 1073 Weston, Kathleen, 125 Wychowski, Czeslaw, 3862 Zock, Christiane, 2719 Wagner, Edward K., 2499 Wettstein, Felix O., 1686, Wyers, Franqoise, 1391 Zsak, Laszlo, 4030 Wagner, Robert R., 239 2938 Zuckermann, Federico, 2764 Wahren, B., 2017 Whang, Young, 1796 Yaginuma, Katsuyuki, 1808 zur Hausen, Harald, 119 SUBJECT INDEX VOLUME 61

A antigen virus, 787 maturation pathways Marek's disease herpesvirus polypeptide modulation by early region 1A, 787 role, 937 gene repeated sequence element Agnoprotein synthesis identification, 2614 identification and localization, 2555 simian virus 40 mutant Abelson murine leukemia virus packaging signal characterization, 2555 late mRNA translation initiation, 2331 clonal dominance and progression ribonucleoprotein complexes in infected AKR murine leukemia virus integration events, 2192 cells germ line integration into retroviruslike lymphomagenesis, 2192 mRNA and hnRNA association, 3276 sequence helper Moloney MuLV LTR Adenovirus type 7 long terminal repeat analysis, 701 role in tumor formation, 3266 temperature-sensitive mutants Akvr-l restriction gene Acyclovir isolation and characterization, 3089 murine leukemia virus dual infection with herpes simplex virus Adenovirus type 12 characterization, 308 and Epstein-Barr virus early region 1A Aleutian disease virus effects of 9-(1,3-dihydroxy-2- interferon induction, 2326 acute interstitial pneumonia in mink kits propoxymethyl)guanine and, 607 stimulatory function, 2326 sequential development, 81 Acylation hamster cell DNA insertion in situ hybridization technique human adenovirus type 5 integration in intracisternal A particle cellular localization of replication, early region 1B 176R protein, 3227 genome, 2719 2407 Adeno-associated virus Adenovirus type 35 a Genes hydroxyurea-pretreated cells early glycoprotein E29 a-trans-inducing factor-dependent helper-independent replication, 972 characterization, 3665 activation recombinant plasmid comparison with adenovirus type 2, herpes simplex virus type 1, 992 DNA rescue and replication, 3096 3665 myxoma virus epidermal growth factor S-Adenosylhomocysteine Adenovirus types 2 and 5 and transforming growth factor Epstein-Barr virus DNA ElA gene products mapping and sequencing, 1271 effects on transformation, expression, susceptibility to natural killer cell alpha mRNAs and methylation, 221 lysis, 3510 herpes simplex virus type 1 vhsl mutant Adenovirus expression system human lymphoid cell cultures stability of immediate-early middle T-antigen expression productive infection, 1466 polypeptides, 604 characterization, 1221 Adenovirus vector Amino-terminal sequence Adenovirus serotype 2 Epstein-Barr virus nuclear antigen herpes simplex virus type 1 glycoprotein nuclear matrix structure EBNA3 gene B rearrangements after infection, 1007 mapping, 3340 synthesis in vitro, 1 Adenovirus type 2 overexpression in human cells, 3340 Amphotropic murine leukemia virus core nucleoprotein subunits polyomavirus middle T antigen env-specific proviral DNAs isolation and characterization, 3335 overproduction in mammalian cells, absence from Mus germ line, 2225 EIA 12S gene product 1226 Antibody response DNA synthesis induction, 673 Adenoviruses inactivated influenza virus vaccine proliferation in epithelial cells, 673 cytoskeletal protein vimentin hemagglutinin-specific immunoglobulin Ela proteins cleavage and processing, 2559 A synthesis, 2150 differential nuclear localization, 247 early occurrence in infection, 2559 induction intragastrically, 2150 E2A promoter E3 region lymphocyte homing, 2150 gene expression, 3710 pre-mRNA processing effect, 3938 lymphocytic choriomeningitis virus methylation pattern stability, 3710 fowl adenovirus type 1 infection early region 1B proteins DNA-transformed cells Lyt-2+ T lymphocyte role, 1867 amino terminus similarity with 495R preferential clustering of viral DNA, recovery mechanism, 1867 and 155R proteins, 3879 151 scrapie-associated fibril proteins identification, 3879 site of chromosomal rearrangements, induction in mice, 3688 early region 4 H2dI807 mutant 151 vesicular stomatitis virus serotypes particle assembly requirements, 3759 human adenovirus type 2 cell membrane asymmetrically cross-reactive IVa2 promoter permeability changes antibodies, 2509 RNA synthesis regulation, 646 Na+,K+-ATPase role, 883 immunodominance of serotype-specific transcription factor identification, 646 interactions between ElA and E1B determinants, 2509 natural killer cell cytolytic competence proteins Antibody-binding epitope immunological surveillance, 2155 expression of mutant phenotypes, 426 feline leukemia virus variant tumor susceptibility of athymic Adenovirus-transformed cell lines antibody resistance, 3410 rodents, 2155 mammalian recombination events Antigenic drift transcription termination signals insertion sites, 344 visna virus envelope glycoprotein gpl35 cat mRNA inhibition, 2770 transcriptional activities, 344 topographical rearrangements, 1019 DNA sequence localization, 2770 rat hepatocytes Antigenic epitopes Adenovirus type 5 ElA and E1B gene transfection, 3570 human immunodeficiency virus envelope core nucleoprotein subunits Adenylate cyclase system proteins isolation and characterization, 3335 JHM virus expression computer-assisted analysis, 570 DNA polymerase mutation activation in rat cells, 3795 prediction in conserved and variable transformation ability, 3630 demyelinating disease model, 3795 regions, 570 early region 1B 176R protein Agnogene defects Antigenic properties acylation, 3227 simian virus 40 VP1 missense mutations feline coronavirus isolates early region 4-encoded polypeptides LP1 and VP1 interaction, 3190 comparison, 2607 analysis, 543 suppression, 3190 peplomer glycoprotein differences, interferon treatment effects Agnoprotein mutants 2607 coinfection with vesicular stomatitis simian virus 40 replication and feline infectious peritonitis virus isolates viii VOL. 61, 1987 SUBJECT INDEX ix

differences, 2655 location, transcription, and sequence, Azidothymidine human papillomavirus types 6b and 16 661 avian leukosis virus Li ORFs early 35- and 94-kilodalton protein genes inhibitory effect, 2800 characterization, 2389 divergent transcription, 2264 human immunodeficiency virus infection poliovirus type 3 HindIII-K significance, 2264 effects on replication in T cells, 3769 modification by host enzymes, 3749 overlapping sets of RNAs vaccine implications, 3749 gene organization in EcoRI J and N Antigenic relatedness fragments, 3048 B and D gene promoters human respiratory syncytial virus nucleotide sequence and restriction bacteriophage S13 subgroups A and B map, 3048 mapping, 3694 F and G glycoprotein role in temporal control determination, 3048 B19 parvovirus immunity, 3163 regulatory gene IE-1 novel transcription map, 2395 vaccinia virus recombinant-conferred expression, 2091 Bacteriophages protection, 3163 sequence, 2091 bacteriophage Cflt Antigenic variation Avian erythroblastosis viruses integration of DNA, 60 equine infectious anemia virus gag-erbB fused gene bacteriophage Cp-1 lysin gene cpl immune response role, 3783 transforming ability, 1665 cloning and purification, 2573 equine infectious anemia virus variants Avian hepadnaviruses muramidase characterization, 2573 glycoprotein gp9O epitopes, 2956 pre-S polypeptide bacteriophage X monoclonal antibody analysis, 2956 characterization, 1384 expression in UV-irradiated cells and Antigenicity role in genomic replication, 3322 minicells, 3254 hepatitis A virus genome Avian leukemia virus E26 protein synthesis and degradation, cDNA expression, 3645 infected hematopoietic cells and 3254 Antigen-presenting cells fibroblasts bacteriophage P22 gene 23 product herpes simplex virus type 1 virulence proviral expression, 3058 cis specificity, 2316 Langerhans cell density role, 2515 transforming and mitogenic effects, expression, 2316 mouse age and genetic strain role, 3058 bacteriophage P22 late genes 2515 Avian leukosis virus expression and regulation, 3621 virus strain pathogenicity role, 2515 azidothymidine treatment lacZ gene fusion, 3621 influenza virus hemagglutinin molecule inhibitory effect, 2800 bacteriophage 4) helper T-cell role, 1375 5' long terminal repeats transcription termination, 1751 receptor-binding activity, 1375 functional impairments in tumors, bacteriophage 4)6 Anti-idiotypic antibodies 2489 nucleocapsid structure, 2362 production against polyomavirus pol protein processing bacteriophage 4)6 nucleocapsid monoclonal antibody identification of new pol domain, 534 protein P1 composition, 2621 infection prevention in mouse kidney Rous-associated virus-0 ev expression bacteriophage 429 DNA-protein p3 cells, 2747 response to exogenous avian leukosis complex Antipeptide antibodies virus infection, 722 NH4' ion effect, 3983 feline leukemia virus Avian leukosis virus provirus bacteriophage OX174 envelope gene neutralizing regions, 8 chicken bursal lymphoma LL6 mapping, 3694 herpes simplex virus type 1 glycoprotein characterization, 1828 bacteriophage PRD1 D N-terminal synthetic peptides c-myc relationship, 1828 genome contains long, inverted group VII monoclonal antibody Avian leukosis virus subgroup F terminal repeats, 594 analysis, 3607 recombinants bacteriophage S13 B and D gene structural properties and reactivity, induction of neoplastic diseases, 1203 promoters 3607 sequence identification, 1203 mapping by footprinting and Antisense RNA Avian myeloblastosis virus exonuclease analysis, 3694 Rous sarcoma virus env gene expression c-myb gene expression bacteriophage S13 replicative form I replication inhibition, 921 p48v-myb effect, 3284 DNA Aphidicolin-resistant mutants p48vmyb transformation RNA polymerase-binding site herpes simplex virus type 2 env-encoded residues unnecessary, localization, 2297 DNA sequence analysis, 388 933 bacteriophage T4 Aphthovirus type 01 strain Campos Avian myelocytomatosis virus MC29 DNA sequence analysis, 2828 attenuated and virulent recombinants deletion mutants genetic control of capsid length, 2823, isolation and characterization, 419 biological properties, 2138 2828, 2835 Arenaviruses quail macrophage transformation, 2138 identification of two new genes, 366 GP-C glycoproteins Avian retroviruses petite and petite/giant mutants, 2828 cleavage site conservation, 982 MH2 virus v-mil sequences ptg mutant phenotypes, 2835 definition by site-specific antibodies, propagation in vivo or in vitro, 1949 ptg mutation localization, 2823 982 v-mil oncogene bacteriophage T4 head assembly art gene protein fibroblast transformation parameters, pathway human T-lymphotropic virus type III 1717 maturation of prohead core, 113 expression in bacteria, 633 homology with v-raf, 1717 bacteriophage T4 rII genes Assembly pathway Avian sarcoma and leukosis viruses lambda rex gene interaction, 3790 bacteriophage T4 head long terminal repeat (LTR)-LTR junction bacteriophage T4 RNA maturation of prohead core, 113 cleavage and growth sites, 1999 polymerase-binding protein A+T-rich region pol-endo gene recognition, 1999 gene identification, 597 simian virus 40 mutant Avian sarcoma virus bacteriophage T7 genes 3 and 19 COS cell accumulation, 2322 pol protein processing amber mutations effects, 3499 DNA replication function, 2322 identification of new pol domain, 534 multidimensional analysis, 3499 Autographa californica nuclear 3'-Azido-3'-deoxythymidine choleraphage 4)149 polyhedrosis virus avian leukosis virus replication and packaging, 3999 arginine-rich polypeptide gene replication inhibition, 2800 coliphage QB P-subunit protein x SUBJECT INDEX J. VIROL.

interference with viral infection, 3946 Bicistronic mRNA homology with other autonomous par- RNA replicase function, 3946 Epstein-Barr virus nuclear proteins voviruses, 3612 corynebacteriophage CL31 identification and analysis, 945 identification, 3612 expression in E. coli, 1540 Bicistronic RNA Bovine virus diarrhea virus structural characteristics, 1540 measles virus phosphoprotein and matrix anticellular monoclonal antibodies lambda rex genes protein bovine enterovirus-3 inhibition, 2050 T4 rII gene interaction, 3790 structure and function, 584 Brome mosaic virus mycoplasma viruses L2 and L2insl BK virus deletion analysis origins and termini mapping, 1909 transcriptional control region RNA3 amplification requirements, XplO genome structure and function, 1747 1457 rifampin resistance, 1695 Bluetongue virus BZLF1 open reading frame transcription regulation, 1695 genetic reassortants Epstein-Barr virus polymorphic proteins Baculovirus expression system hemagglutinin gene identification, 2304 latency disruption, 3672 simian rotavirus SAl recombinant genome segment reassortment, 2670 major capsid antigen VP6 synthesis, nonstructural protein NS2 Calcium-binding activity 1488 phosphorylation and purification, 3589 polyomavirus VP1 capsid protein Baculovirus vectors single-stranded RNA affinity, 3589 localization, 2934 human immunodeficiency virus envelope Bluetongue virus serotypes 10 and 17 Campoletis sonorensis virus glycoproteins genetic reassortment in vivo cross-hybridizing sequences expression, 3617 mixed infection in sheep, 1086 physical analysis, 2589 human T-cell leukemia virus type I p40" BMRF1 and BMRF2 open reading frames tandemly repeated element identifica- protein Epstein-Barr virus BamHI fragment M tion, 2589 synthesis in eucaryotic cells, 708 cDNA clone characterization, 2943 Cap-binding complex influenza viral polymerase proteins overlapping mRNA isolation, 2943 p220 in poliovirus-infected cells expression and complex formation, Borna disease virus monoclonal antibody-aided character- 361 pathogenesis ization, 2702 polyomavirus large T antigen incubation period, 3431 subcellular distribution and conformer expression, 1712 intra-axonal transport, 3431 identification, 2702 simian virus 40 intron-containing genes Bottom-component RNA Capsid assembly expression, 1761 cowpea mosaic virus peptide bacteriophage T4 petite and petite/giant Baculoviruses detection of novel protein, 236 mutations Autographa californica nuclear poly- cowpea mosaic virus precursor protein DNA sequence analysis, 2828 hedrosis virus genome cleavage inhibitor activity, 912 bacteriophage T4 ptg mutations gene organization in EcoRl J and N Bovine enterovirus-3 clustering in gene 23, 2823 fragments, 3048 bovine virus diarrhea virus monoclonal phenotypes, 2835 overlapping sets of RNAs, 3048 antibodies Capsid protease temporal control determination, 3048 inhibition, 2050 Semliki Forest virus structural polypro- Autographa californica nuclear poly- Bovine herpesvirus type 1 tein hedrosis virus regulatory genes gI, glll, and gIV expression role and processing, 1301 expression, 2091 glycoprotein synthesis, 3292 Capsid protein VP1 sequence, 2091 vaccine role, 3292 foot-and-mouth disease virus subtyping gene encoding arginine-rich polypeptide latency-related RNA nucleotide sequence analysis, 1621 location, transcription, and sequence, trigeminal ganglia mapping, 3827 Capsid proteins 661 thymidine kinase gene parvovirus B19 BamHI fragment M map location, 4023 characterization, 2627 Epstein-Barr virus cDNA clone Bovine leukemia virus Cardioviruses characterization, 2943 trans-acting factor and cis-acting Theiler's murine encephalomyelitis virus overlapping mRNA isolation, 2943 response element interaction classification, 1507 BamHI M fragment transcription control, 2462 nucleotide sequence analysis, 1507 Epstein-Barr virus BMRF1 and BMLF1 X-region nuclear phosphoprotein cDNA clone early antigens expression in infected cells, 1577 foot-and-mouth disease virus polypro- cat gene transcription, 3310 Bovine papillomavirus teins BamHI-H and -F regions protein analysis, 3596 proteases 3C and L roles, 3199 Epstein-Barr virus cDNA clones Bovine papillomavirus type 1 proteolytic processing, 3199 isolation and characterization, 2902 3' open reading frames hepatitis A virus B-cell cycle mutational analysis, 3889 infectious RNA transcription vector, measles virus infection nucleotide 3225 splice junction, 3889 3035 immunoglobulin secretion block, 3441 E2-responsive elements hepatitis A virus genome sequence of events, 3441 localization, 2128 antigenicity, 3645 B-cell growth factor transcriptional regulation, 2128 expression in E. coli, 3645 Epstein-Barr virus open reading frame E4 infectious hematopoietic necrosis virus complement receptor CR2 binding, late gene expression, 1248 glycoprotein gene 774 mutational analysis, 1248 mRNA sequence, 1342 synergism, 774 open reading frame proteins Moloney murine leukemia virus env B-cell transformation characterization, 1655 message Epstein-Barr virus nuclear antigen DNA-binding activity, 1655 splice acceptor site, 2038 EBNA 2 RNA levels and protein expression murine retroviral expression vector growth phenotype influence, 1310 tumorigenicity in hamster cells, 2924 pp60C-src clone generation, 1731 BHRF1 open reading frame transforming region promoters Sinbis virus Epstein-Barr virus BamHI-H and -F re- identification, 2240 lethal mutation mapping, 3809 gions processing sites, 2240 RNA transcript production, 3809 cDNA clones characterization and iso- Bovine parvovirus cDNA hybridization lation, 2902 nonstructural proteins encephalomyocarditis virus RNA trans- VOL. 61, 1987 SUBJECT INDEX xi

lation human immunodeficiency virus identification, 2938 effects, 2033 productive, persistent infection, 209 Coumermycin Al and novobiocin cDNA sequencing Complement C3d fragment herpes simplex virus type 1-infected foot-and-mouth disease virus subtyping Epstein-Barr virus glycoprotein gp350 mouse cells analysis, 1621 complement receptor binding action, reactivation inhibition, 3288 cDNA transfection 1416 Cowpea mosaic virus Sendai virus C gene sequence homology, 1416 bottom-component RNA induction of interferon, 625 Complement receptor CR2 characterization, 912 cDNA-RNA hybridization Epstein-Barr virus cleavage inhibitor activity, 912 hepatitis A virus synergism with B-cell growth factor, detection of novel protein, 236 heterogeneity among human and non- 774 Cross-reactivity human strains, 735 Concatemeric DNA herpes simplex virus types 1 and 2, Ep- c-fos proto-oncogene bacteriophage T7 genes 3 and 19 stein-Barr virus, and cytomegalo- avian transforming virus NK24 amber mutations effects, 3499 virus cloning, 4012 multidimensional analysis, 3499 antigenic analysis, 1125 nucleotide sequence analysis, 4012 Condylomata acuminata Cryoelectron microscopy Chicken c-fos gene human papillomavirus type 6b Li open La Crosse virus cloning, 4012 reading frame protein structural features, 2319 nucleotide sequence analysis, 4012 antibody detection, 2684 vitrified-hydrated virions, 2319 Chicken embryo fibroblasts identification, 2684 Cyclic AMP avian leukemia virus E26 infection Core antigen polyomavirus and simian virus 40 trans- growth potential effect, 3058 hepatitis B virus DNA clones formants proviral expression, 3058 expression in human hepatocellular effect on normal cell proliferation, Chicken v-fos gene carcinoma cells, 3555 1546 avian transforming retrovirus hepatitis B virus pre-S and precore se- Cytolytic susceptibility characterization, 3733 quences adenovirus types 2 and 5 ElA gene nephroblastoma isolation, 3733 expression, 683 products Chromatin structure influences, 683 natural killer cells and activated Moloney murine leukemia virus Core antigen expression macrophages, 3510 proviral integration sites, 336 hepatitis B virus Cytolytic T lymphocytes cis specificity phosphorylation and protein analysis murine cytomegalovirus immediate-early bacteriophage P22 gene 23 product in vivo, 955 gene products determination, 2316 translation in vivo and in vitro, 3109 host immune response, 2054 expression, 2316 Core nucleoproteins Cytomegalovirus, human cis-Acting elements adenovirus types 2 and 5 subunits DNA polymerase gene Rous sarcoma virus Prague A DNA isolation and characterization, 3335 genomic localization, 119 gag gene role in transformation, 3401 Core origin homology with other herpesviruses, localization, 3401 simian virus 40 72-bp-repeat enhancer 119, 125 Classification position and orientation effects, 2973 sequence and transcription analysis, endogenous murine leukemia viruses replication role, 2973 119, 125 recombination potential, 2659 Core proteins DNA-binding protein structural relationships, 2659 duck hepatitis B virus pre-C region purification and gene mapping, 3143 Clearance mechanisms function, 3701 similarity to HSV ICP8, 3143 lymphocytic choriomeningitis virus synthesis and secretion, 3701 immediate-early region 2 gene products immune therapy of persistent infec- equine infectious anemia virus gag poly- identification and characterization, tion, 3920 protein 3214 lymphocytic choriomeningitis virus ef- characterization, 1116 inducible promoter regulation, 3214 fector cells isolation, 1116 large structural phosphoprotein gene intercell cooperation, 3930 Coronaviruses pp150 Clonal dominance duck hepatitis B virus DNA synthesis map position, 1358 Abelson murine leukemia virus lympho- initiation and termination, 3832 nucleotide sequence, 1358 magenesis feline coronavirus isolates transcription analysis, 1358 *integration events, 2192 antigenic comparison, 2607 phosphonoacetic acid-resistant mutants transformation rate, 2192 peplomer glycoprotein differences, isolation and characterization, 1291 c-myb activation 2607 phosphoproteins pp65 and pp7l Moloney murine leukemia virus-induced mouse hepatitis virus 5'-end RNA nucleotide sequence, 446 myeloid tumors RNA polymerase structure, 3968 primary structure and transcription, v-abl involvement lacking, 3721 sequence and translation, 3968 446 c-myb expression mouse hepatitis virus A59 Cytomegalovirus, murine avian erythroblastosis virus-transformed replication in vitro, 1814 adoptive cellular immunity erythroblasts mouse hepatitis virus A59 glycoprotein modification of adrenalitis, 23 effect of p48vmyb expression, 3284 El immediate-early genes c-myb gene expression, 2042 location, transcripts, and translation retroviral insertion in murine monocytic Golgi region localization, 2042 products, 526 leukemias mouse hepatitis virus-binding activity interferon-dependent and -independent RNA species characterization, 2754 genetic resistance, 185 replication restriction transcript rearrangement, 2754 Corynebacterium lilium bacteriophage genetic resistance, 1875 c-myc activation CL31 murine cytomegalovirus immediate-early reticuloendotheliosis virus B-lymphoma structural characteristics gene 1 induction expression in E. coli, 1540 sequence and structural organization, mutated chicken syncytial virus pro- Cottontail rabbit papillomavirus 1901 virus, 2084 E6-coded polypeptides nonstructural immediate-early antigens Colorectal cell lines early region transcription, 2938 protective immunity role, 3102 xii SUBJECT INDEX J. VIROL.

peritoneal macrophage infection organization and sequence, 553 association, 2947 comparative study, 3602 Dependovirus human cytomegalovirus phosphonoacetic H-2-determined sensitivity, 3602 host-dependent evolution acid-resistant mutants Cytomegaloviruses homology with densovirus and parvo- isolation and characterization, 1291 herpes simplex virus types 1 and 2 and virus, 553 DNA polymerase gene Epstein-Barr virus Dephosphorylation herpes simplex virus type 1 vector cross-reactivity, 1125 simian virus 40 large T antigen functional expression, 1704 immediate-early IE94 promoter ATPase and DNA-binding effect, 3373 human cytomegalovirus herpes simplex virus regulatory re- DNA replication stimulation, 3373 genomic localization, 119 sponse, 819 9-(1,3-Dihydroxy-2-propoxymethyl)guanine homology with other herpesviruses, interferon synthesis stimulation, 819 dual infection with herpes simplex virus 119, 125 simian and human immediate-early IE94 and Epstein-Barr virus sequence and transcription analysis, promoters effects of acyclovir and, 607 125 nuclear factor 1-binding sites, 1559 DNA amplification DNA recombination tandem repeat elements, 1559 human immunodeficiency virus vaccinia virus genome Cytopathic effects sequence identification, 1690 mechanisms, 1788 human immunodeficiency virus simian virus 40 synthesis DNA replication cell fusion requirements, 3114 herpes simplex virus infection adeno-associated virus genome mechanism of cell killing, 3114 enhancement, 1427 recombinant plasmid vector, 3096 human immunodeficiency virus strains DNA encapsidation adenovirus infection biologic behavior in immortalized adenovirus type S deletion mutants nuclear matrix structural alterations, cells, 1602 packaging signal characterization, 2555 1007 ovine lentiviruses repeated sequence element identified, Aleutian mink disease virus pathogenicity correlation in vivo, 4038 2555 in situ hybridization technique, 2407 Cytoplasmic-localization mutant pSVCT3 DNA excision avian hepatitis B virus precore region simian virus 40 nuclear large T antigen polyomavirus-mouse hybrid replicon role, 3322 transformation of precrisis human site-specific recombination event, 840 duck hepatitis B virus cells, 3521 DNA expression vertical transmission, 2273 Cytotoxic T lymphocytes Epstein-Barr virus immortalization in yolk sac of developing embryos, 2273 adenovirus type 2-transformed cells neonatal B lymphocytes Epstein-Barr virus genomes lysis by natural killer cells, 2155 transforming ability, 1552 density transfer approach, 1743 tumor susceptibility of athymic ro- DNA extraction hepatitis B virus dents, 2155 JC virus multiplication plus- and minus-strand characteriza- herpes simplex virus glycoprotein gC owl monkey tumor cells, 1435 tion, 904 expression DNA insertion herpes simplex virus ICP4 specificity, 2438 helper-independent retroviral vectors nuclear association, 276 influenza A virus antigen recognition adaptor plasmid development, 3004 herpes simplex virus type 1 ICP8 gene major histocompatibility complex class procedure simplification, 3004 mapping of transcription initiation I responsiveness, 1098 DNA integration sites, 615 Cytotoxic T-cell response filamentous bacteriophage Cflt mycoplasma viruses L2 and L2insl herpes simplex virus type 1 host chromosomal DNA, 60 origins and termini mapping, 1909 glycoprotein D expression, 726 hepatitis B virus simian virus 40 core origin varicella-zoster virus analysis of unoccupied sites, 1180 sequence analysis, 2143 detection and frequency analysis, 3463 chromosomal rearrangements, 3848 T-antigen-binding domain, 2143 Cytotoxic T-lymphocyte response site-specific recombination, 3491 simian virus 40 deletion mutants vesicular stomatitis virus nucleoprotein hepatitis B virus integration sites characterization of late promoter se- antigen hepatocellular carcinoma and chronic quences, 167 bm3 mutant recognition decreased, hepatitis tissue isolates, 1808 simian virus 40 expression 1992 structural analyses, 1808 spontaneous T-antigen mutants, 2864 human papillomavirus type 18 simian virus 40 large T antigen localization, 1682 ATP enhancement, 3649 Defective interfering particles Moloney murine leukemia virus mutants characterization of trans-dominant de- influenza virus endonuclease activity characterized, fective mutants, 436 identification in nature, 1517 1756 origin binding, 3649 protective effect, 1517 murine leukemia virus simian virus 40 large T-antigen function interaction with vesicular stomatitis vi- oligomeric form, 1964 monoclonal antibody probes, 411 rus DNA methylation simian virus 40 mutation complete resistance to DI particles, Epstein-Barr virus expression A+T-rich sequence function, 2322 454 effects of S-adenosylhomocysteine and COS cell growth, 2322 Deletion mutants analogs, 221 simian virus 40 T antigen herpes simplex virus type 1 ICP8 protein human immunodeficiency virus nonpermissiveness in mouse cells, 851 characterization of transformed cell modulation of gene expression, 1253 vaccinia virus gene lines, 1136 DNA polymerase activity molecular genetic analysis, 3152 expression, 1136 adenovirus type 5 E2B region role, 3152 Dengue virus temperature-sensitive mutations, 3630 vaccinia virus late promoter structural and nonstructural proteins transformation ability, 3630 transcriptional regulatory regions, 75 expression by recombinant vaccinia bacteriophage +29 protein p3 vaccinia virus mutant virus, 4019 complex formation, 3983 nucleotide sequence and organization, Densovirus NH4+ ion effect, 3983 1398 host-dependent evolution of parvovi- Epstein-Barr virus required region, 1398 ruses immune serum preparation, 3331 DNA rescue homology with parvovirus and depen- Epstein-Barr virus early antigen diffuse adeno-associated virus genome dovirus, 553 component recombinant plasmid vector, 3096 VOL. 61, 1987 SUBJECT INDEX xiii

DNA sequences DNA-dependent ATPase virus avian leukosis virus proviral mutation vaccinia virus nucleoside triphosphate biomolecular analysis, 3306 chicken bursal lymphoma LL6 charac- phosphohydrolase I gene Epstein-Barr virus strains terization, 1828 identification, 1738 abortive infection in Raji cells, 1985 c-myc relationship, 1828 DNase 1-hypersensitive sites defective genome sequences, 1985 fowl adenovirus type 1 Moloney murine leukemia virus vector Early gene expression DNA-transformed cells long terminal repeats adenovirus ElA and E1B proteins preferential clustering of viral DNA, analysis, 1368 expression of mutant phenotypes, 426 151 significance, 1368 interactions, 426 site of chromosomal rearrangement, Drosophila melanogaster cells Early region 1A 151 vesicular stomatitis virus replication adenovirus type 5 hepatitis B virus clones cytopathogenicity, 1391 interferon treatment effects, 787 expression in human hepatocellular leader RNA synthesis, 1391 modulation, 787 carcinoma cells, 3555 Dsi-J frequent integration region adenovirus type 12 herpes simplex virus type 2 Moloney murine leukemia virus interferon induction, 2326 aphidicolin-resistant mutants, 388 isolation from rat thymomas, 1164 stimulatory function, 2326 human papillomavirus type 16 D-type retroviruses Early region 1B protein analysis, 962 myristylation adenovirus type 2 open reading frames cervical carcinoma cell lines, 962 role in intracellular transport and as- amino terminus shared with 495R and human papillomavirus type 16 in SK-v sembly, 1045 155R proteins, 3879 cells Duck hepatitis B virus identification, 3879 integration, 3295 antibody reactivity in infected ducks human adenovirus type 5 mouse mammary tumor virus clones humoral immune response, 916 acylation of the 176R protein, 3227 comparison with other retroviruses, DNA synthesis Early region 4 480 initiation and termination, 3832 adenovirus type 2 H2dI807 mutant polyomavirus recombinants envelope proteins particle assembly requirements, 3759 genetic determinants, 2232 biochemical and immunological char- Early region 4 polypeptides induction of tumors in mice, 2232 acterization, 2280 adenovirus type 5 DNA synthesis comparison of preS and S proteins, analysis and synthesis, 543 adenovirus type 2 ElA 12S gene product 2280 EBNA mRNA family induction in cells, 673 pre-C region Epstein-Barr virus promoter avian leukosis virus core protein synthesis and secretion, mapping in B95-8 cells, 3424 replication inhibition by azidothymi- 3701 transcription initiation point, 3424 dine, 2800 function, 3701 Ecotropic murine leukemia virus choleraphage 4149 pre-S polypeptide long terminal repeat recombinants replication and packaging, 3999 characterization, 1384 tissue-specific replication, 1350 duck hepatitis B virus yolk sac of developing embryos xenotropic and mink cell focus-forming initiation and termination, 3832 nucleic acid hybridization, 2273 viruses and proviral genes herpes simplex virus type 1 S compo- vertical transmission, 2273 env gene probes, 3082 nent wild mouse origins, 3082 open reading frame origin, 3349 Ecotropic retrovirus DNA transcription ElA gene horizontal transmission in mice, 1037 bacteriophage 4) adenovirus type 2 12S protein Embryonal carcinoma cells termination, 1751 DNA synthesis induction, 673 retroviral vectors mammalian recombination events adenovirus-transformed hepatocytes, gene expression, 2742 insertion sites, 344 3570 sequence element mediation, 2742 nucleotide sequences, 344 E1B gene Encephalomyocarditis virus DNA transformation adenovirus-transformed hepatocytes, cDNA hybridization herpes simplex virus type 1 sequences 3570 RNA translation effects, 2033 TK+ transformant inhibition, 2989 E2 trans-activation interferon action in RD-114 clonal deriv- DNA-binding activity bovine papillomavirus type 1 long con- atives simian virus 40 large T antigen trol region different antiviral and gene-inducing oligomerization, 2076 localization, 2128 responses, 2727 DNA-binding domain transcriptional regulation, 2128 interferon treatment simian virus 40 large T antigen E2 transcriptional factors expression in RD-114 cells, 1524 analysis, 3326 papillomavirus enhancers 2',5'-oligoadenylate DNA-binding proteins identification, 2599 accumulation in infected mice, 1586 herpes simplex virus type 1 immediate- E2A promoter VP3/VP1 cleavage site mutations early protein ICP4 adenovirus type 2 capsid precursor assembly disrupted, transcription start site, 858 gene expression, 3710 3680 herpes simplex virus type 1 proteins methylation pattern stability, 3710 processing effect, 3680 characterization, 2428 E6 polypeptides Endogenous avian leukosis virus Rous- human cytomegalovirus protein cottontail rabbit papillomavirus associated virus-0 purification and gene mapping, 3143 early region transcription, 2938 ev gene expression similarity to HSV ICP8, 3143 identification, 2938 response to exogenous avian leukosis DNA-binding site E26 leukemia virus virus infection, 722 Epstein-Barr virus nuclear antigen infected hematopoietic cells and fibro- Endogenous ecotropic viruses high concentration-dependent com- blasts AKXD recombinant inbred mice plex, 465 proviral expression, 3058 characterization, 2929 DNA-cell interactions transforming and mitogenic effects, lymphoma susceptibility, 2929 human papillomavirus type 16 3058 Endogenous mouse mammary tumor virus transformation of human fibroblasts Early antigen induction nomenclature proposed, 1651 and keratinocytes, 1061 defective nontransforming Epstein-Barr Endogenous murine leukemia virus xiv SUBJECT INDEX J. VIROL.

classification Rous sarcoma virus mutants herpesvirus saimiri homology, 2063 recombination potential, 2659 intracellular transport and assembly sequence, 2063 structural relationships, 2659 analysis, 2981 membrane protein BNLF-1 Endogenous murine retroviruses Envelope proteins expression in transformed cells, 866 env gene linked to Rmcf locus herpes simplex virus type 1 posttranslational processing, 866 identification of two forms, 29 human immune T-cell response, 1532 microinjection into neonatal B lympho- Endogenous retroviruses visna virus genome cytes 3' long terminal repeat homology with other lentiviruses, 4046 DNA-transforming ability, 1552 propagation as retrotransposons, 1261 hypervariable env gene site detection, nuclear antigen 5 proteins role as transcription promoter, 1261 4046 monoclonal antibody detection, 3870 ERV3 human endogenous provirus Envelope reconstitution multiple protein species expression, mRNA expression, 2182 influenza virus 3870 sequence analysis, 2182 membrane and liposome fusion, 2245 nuclear antigen complex HERV-K genome in human tumor cells env-related fragments DNA-binding site, 465 expression, 2059 amphotropic murine leukemia virus high concentration dependence, 465 organization, 2059 type-specific probe nuclear antigen EBNA 2 Endonuclease activity absence from Mus germ line, 2225 B-cell growth phenotype influence, Moloney murine leukemia virus mutants Epstein-Barr virus 1310 characterization, 1756 16-kilobase-pair palindrome fragment nuclear antigen EBNA3 gene Endopeptidase heterogeneous DNA generation, 1495 mapping, 3340 Rous sarcoma virus glycoprotein muta- sequences, 1495 overexpression by using adenovirus tion 110-kilodalton glycoprotein vector, 3340 processing, 1609 homology to herpes simplex virus gB, nuclear protein analysis proteolytic cleavage site role, 1609 499 bicistronic mRNA identification, 945 Enhancer elements S-adenosylhomocysteine and analogs P3HR1-superinfected Raji cells murine leukemia virus transcriptional effects on transformation, expression, gene expression, 3120 control region and methylation, 221 immediate-early gene isolation, 3120 glucocorticoid regulation, 269 BamHI fragment M transcript p63/LMP protein papillomavirus E2 transcriptional factors cDNA clone characterization, 2943 processing, 2100 identification, 2599 overlapping mRNA isolation, 2943 polymorphic proteins encoded by simian virus 40 72-bp repeat BamHI M fragment BZLF1 core origin replication role, 2973 BMRF1 and BMLF1 early antigens latency disruption, 3672 position and orientation effects, 2973 roles, 3310 serum-free medium simian virus 40 mutations cat gene trans-activation, 3310 B95-8 cell growth, 4033 revertant duplications, 3536 BamHI-H and -F regions lytic-phase expression, 4033 env and src genes cDNA clone isolation and character- Equine herpesvirus 1 Rous sarcoma virus ization, 2902 glycoprotein genes splicing efficiency, 177 B-cell activation Xgtll expression system, 2454 env gene expression complement receptor CR2 binding, map locations, 2454 Rous sarcoma virus 774 monoclonal antibody detection, 2454 simian virus 40 vector, 1276 synergism, 774 Equine infectious anemia virus upstream initiation codon effects, 1276 clones lacking heterogeneous molecules antigenic variants env gene probes abortive infection in Raji cells, 1985 immune selection role, 3783 xenotropic and mink cell focus-forming early antigen induction, 1985 gag-encoded proteins viruses and proviral genes defective nontransforming strain characterization, 1116 wild mouse origins, 3082 biomolecular analysis, 3306 isolation, 1116 env message isolation from patient with chronic glycoprotein gp9O epitopes Moloney murine leukemia virus active infection, 3306 monoclonal antibody antigenic analy- cDNA clone sequence, 2038 dual infection with herpes simplex virus sis, 2956 splice acceptor site, 2038 type 1 neutralizing antibody stimulation, 2956 env mutants effects of acyclovir and 9-(1,3-dihy- long terminal repeats Friend spleen focus-forming virus gp55 droxy-2-propoxymethyl)guanine, characterization, 743 membrane glycoprotein 607 expression, 743 cell surface expression, 2782 early antigen diffuse component parallel persistent infections plasma membrane receptor binding, DNA polymerase relationship, 2947 variation course and extent, 1266 2782 role, 2947 ERV3 human endogenous retrovirus Envelope glycoprotein gpl35 EBNA family of RNAs mRNA expression visna virus point mutations promoter mapping in B95-8 cells, 3424 sequence analysis, 2182 topographical rearrangements during extrachromosomal genomes Erythroleukemia antigenic drift, 1019 density transfer approach, 1743 Friend virus-induced multistage malig- Envelope glycoproteins replication in Raji cells, 1743 nancy Epstein-Barr virus gp350/220 gene glycoprotein gp350 cellular p53 gene rearrangements, 2777 mammalian cell expression, 1796 complement receptor binding action, Erythropoietin response properties, 17% 1416 spleen focus-forming virus strain SFFVp human immunodeficiency virus homology with complement C3d frag- recombinant expression by baculovirus vector, ment, 1416 localization, 1661 3617 glycoprotein gp350/220 gene Eucaryotic initiation factor-2 human immunodeficiency virus mammalian cell expression, 17% poliovirus-infected HeLa cells conserved domains properties, 1796 cellular protein kinase activation, 1781 serum neutralizing antibody recogni- herpes simplex virus types 1 and 2 and phosphorylation inhibition, 1781 tion, 2024 cytomegalovirus Exogenous avian leukosis virus murine leukemia virus cross-reactivity, 1125 endogenous avian leukosis virus Rous- Arg-to-Lys role in processing, 2852 membrane antigen associated virus-0 VOL. 61, 1987 SUBJECT INDEX xv

response to infection, 722 erythropoietin response altered, 1661 herpes simplex virus type 1 mutants localization, 1661 role in infectivity, 600 Friend virus-induced erythroleukemia Glycoprotein El F9 embryonal carcinoma cells cellular p53 rearrangements mouse hepatitis virus A59 retroviral vectors independent origin of tumor clones, Golgi region localization, 2042 gene expression, 3248 2777 Glycoprotein expression Feline c-fes/fps proto-oncogene Friend-mink cell focus-forming virus herpes simplex virus type 1 structure, 2009 Moloney murine leukemia virus recom- cell surface expression, 104 Feline coronaviruses binants flow cytometric analysis, 104 E2 peplomer glycoproteins enhancer sequence roles, 1861 Glycoprotein gBl antigenic comparison, 2607 leukemogenicity, 1861 herpes simplex virus type 1 Patton peplomer (E2) glycoprotein Fusion glycoprotein expression in mammalian cells, 315 antigenic differences, 2655 human parainfluenza virus type 3 Glycoprotein gB2 Feline infectious peritonitis virus contribution to host immunity, 3416 herpes simplex virus type 2 peplomer (E2) glycoprotein expression by vaccinia virus vectors, structure and expression, 326 antigenic differences, 2655 3416 Glycoprotein gC Feline leukemia virus simian virus 5 herpes simplex virus anti-synthetic peptide antibodies protective immunity role, 1972 expression in transfected syngeneic envelope gene neutralizing regions, 8 vaccinia virus recombinants, 1972 cells, 2438 myc-containing variant Fusion protein specificity of cytotoxic T activity in early-passage cells in vitro, measles virus H and F glycoproteins lymphocytes, 2438 3072 protection by immune-stimulating Glycoprotein gG-2 transforming potential, 3072 complexes, 38% herpes simplex virus type 2 subtype B variant clone vaccinia virus 14-kilodalton envelope cleavage event product, 1735 antibody resistance, 3410 protein processing and synthesis, 1735 Feline panleukopenia virus mapping and nucleotide sequence, Glycoprotein gl nonstructural protein 3550 pseudorabies virus Bartha strain expression in E. coli, 621 role in virus release, 2764 multiple forms in infected cells, 621 Glycoprotein glll Feline sarcoma virus Hardy-Zuckerman 2 gag region synthesis pseudorabies virus mutants strain Moloney murine leukemia virus vectors localization and modification, 2962 v-abl insert packaging signal involvement, 1639 Glycoprotein gp5O oncogenicity, 1193 gag-erbB gene pseudorabies virus subunit vaccine sequence, 1193 oncogenes evaluation, 3977 Filamentous bacteriophage Cflt transforming ability, 1665 expression by vaccinia virus vector, host chromosomal DNA gB glycoprotein gene 3977 integration of DNA, 60 herpes simplex virus type 1 Glycoprotein gp52 fim-3 region linker-insertion nonsense mutations, spleen focus-forming virus Friend murine leukemia virus 714 intracellular transport, 4007 proviral integration role, 4043 restriction-site deletion mutations, 714 leukemogenicity, 4007 Foot-and-mouth disease virus gE gene product Glycoprotein gp9O European strain subtyping herpes simplex virus type 1-induced gly- equine infectious anemia virus variants nucleotide sequence analysis, 1621 coprotein glycoprotein gp9O epitopes, 2956 polyproteins complex formation, 2208 monoclonal antibody analysis, 2956 cDNA clone construction, 3199 identification, 2208 Glycoprotein gp350/220 gene proteases 3C and L roles, 3199 immunoglobulin G binding, 2208 Epstein-Barr virus proteolytic processing, 3199 genetic transmission mammalian cell expression, 1796 treatment with ribavirin amphotropic env-specific proviral DNAs properties, 17% cell curing in vitro, 233 absence from Mus germ line, 2225 Glycoprotein gpII Fowl adenovirus type 1 Genome rearrangements varicella-zoster virus 0-linked glycans DNA-transformed cells rotaviruses from immunodeficient host assembly and processing, 2877 preferential clustering of viral DNA, heterogeneity, 3365 Glycoprotein gX 151 Glioma cells pseudorabies virus mutants Friend and Moloney murine leukemia vi- human immunodeficiency virus replication and virulence, 229 ruses expression, 1244 Glycoprotein homology U3 region sequences infectious molecular clones, 3774 Epstein-Barr virus 110-kilodalton glyco- disease specificity determinants, 693 persistent productive infection, 3774 protein Friend murine leukemia virus Glycopeptide mapping homology to herpes simplex virus gB, fim-3 proviral integration region equine infectious anemia infections 499 analysis, 4043 variation course and extent, 1266 Glycoprotein synthesis identification, 4043 Glycoprotein D bovine herpesvirus 1 gI, glll, and gIV long terminal repeat recombinants herpes simplex virus type 1 characterization, 3292 tissue-specific replication, 1350 cytotoxic T-cell response, 726 vaccine role, 3292 Friend spleen focus-forming virus neutralizing antibodies inhibit penetra- Glycoproteins gpl3 and gp32 site-directed env mutants tion, 3356 herpesvirus sylvilagus gp55 cell surface expression, 2782 vaccinia virus vector, 726 antigen identification, 3580 plasma membrane receptor binding, herpes simplex virus type 1 N-terminal characterization, 3580 2782 synthetic peptides neutralization, 3580 Friend viruses antipeptide and group VII monoclonal Glycoproteins gp85 and gp37 natural killer cell activity antibody analyses, 3607 Rous sarcoma virus mutation stem cell suppression, 2631 structural properties and reactivity, processing, 1609 spleen focus-forming virus strain SFFVp 3607 proteolytic cleavage site role, 1609 recombinant Glycoprotein E gpS5 membrane glycoprotein xvi SUBJECT INDEX J. VIROL.

Friend spleen focus-forming virus env influence of 5'-terminal sequences, 35 vaccinia virus recombinants mutants RNA packaging, 35 antibodies to pre-S and S epitopes, cell surface expression, 2782 human hepatitis delta virus 1286 plasma membrane receptor binding, replication in woodchuck hepatocyte expression of middle surface antigen, 2782 cultures, 2891 1286 gp7O expression Hepatitis A virus Hepatocellular carcinoma simian virus 40-transformed fibroblasts cDNA clones hepatitis B virus integration sites macrophage-resistant cells, 928 infectious RNA transcription vector, structural analyses, 1808 Ground squirrel hepatitis virus 3035 tissue isolates, 1808 polyribosomes and core particles complete nucleotide sequence of wild Herpes simplex virus influence of 5'-terminal sequences, 35 type cytomegalovirus immediate-early IE94 RNA packaging, 35 comparison with other picornaviruses, promoter woodchuck hepatitis recombinants 50 interferon synthesis stimulation, 819 infectivity, 3241 comparison with other strains, 50 regulatory response, 819 synthesis of novel viruses, 3241 human and nonhuman strain analysis glycoprotein expression in transfected Growth requirements cDNA-RNA hybridization, 735 syngeneic cells Epstein-Barr virus lytic phase genomic heterogeneity, 735 specificity of cytotoxic T expression in serum-free medium, neutralization escape mutants lymphocytes, 2438 4033 immunogenic neutralization sites, 491 glycoprotein gB VP1 recombinant protein homology to Epstein-Barr virus glyco- antigenicity, 3645 protein, 499 Ha-ras cotransfection cDNA expression in E. coli, 3645 immediate-early gene promoters simian virus 40 Hepatitis B virus transcriptional activator response, transformation cooperation, 2648 core antigen expression 3167 Hardy-Zuckerman 2 feline sarcoma virus phosphorylation and protein analysis mRNA stability v-abl insert in vivo, 955 effects, 2198 oncogenicity, 1193 core gene vhs mutant function, 2198 specificity, 1193 expression in vivo and in vitro, 3109 nerve growth factor deprivation Helper T cells core, X, and S region sequences latency in vitro, 2311 lymphocytic choriomeningitis virus expression, 1108 thymidine kinase-negative mutants virus-lymphocyte interaction, 1571 transcription, 1108 complementation in vivo, 2171 Helper virus DNA clones in human hepatocellular trigeminal ganglion infection, 2171 Abelson virus-induced lymphoma carcinoma cells transcriptional activator protein ICP4 role of Moloney MuLV LTR, 3266 expression of preS, S, C, and P genes, nuclear association, 276 adeno-associated virus hydroxyurea-pre- 3555 uracil-DNA glycosylase treated cells sequence, 3555 activity origin, 3040 helper-independent replication, 972 integrated DNA in hepatocellular carci- Herpes simplex virus type 1 Hemagglutinin nomas activation of human immunodeficiency bluetongue virus reassortants chromosomal rearrangements, 3848 virus, 3726 identification, 2304 inverted duplication, 3848 a-trans-inducing factor-dependent acti- outer capsid protein association, 2304 integration vation of a genes influenza virus analysis of unoccupied sites, 1180 characterization and nucleotide se- antigen-presenting cell activity, 1375 middle and large surface antigen genes quence, 992 receptor-binding activity, 1375 expression in Saccharomyces cerevi- cellular receptor binding role in B-cell mitogenesis, 214 siae, 3543 neomycin effect, 3388 influenza virus variants multiple DNA-integration sites DNA polymerase gene monoclonal antibody selected, 206 hepatocellular carcinoma and chronic expression, 1704 receptor-binding characteristics, 206 hepatitis tissue isolates, 1808 vector construction, 1704 Hemagglutinin protein structural analyses, 1808 DNA-binding and trans-inducing pro- measles virus F and H glycoproteins preSl protein teins protection by immune-stimulating acylation with myristic acid, 1672 characterization, 2428 complexes, 3896 regulation of secretion of majoi sur- dual infection with Epstein-Barr virus Hemagglutinin-neuraminidase glycoprotein face antigen, 782 effects of acyclovir and 9-(1,3-dihy- human parainfluenza virus type 3 replication strategy droxy-2-propoxymethyl)guanine, antigenic structure, 1473 DNA plus- and minus-strand charac- 607 contribution to host immunity, 3416 terization, 904 gB glycoprotein gene expression by vaccinia virus vectors, 5' end of RNA pregenome determina- homology with pseudorabies virus gll 3416 tion, 904 gene, 2691 monoclonal antibody selection, 1473 site-specific recombination model gB glycoprotein gene-transformed cell sequence analysis of variants, 1473 analysis, 3491 line simian virus S characterization, 3491 linker-insertion nonsense mutations, protective immunity role, 1972 subtypes adr, ayr, and adyr 714 vaccinia virus recombinants, 1972 characterization, 3030 restriction-site deletion mutations, 714 Hepadnaviruses point mutation in S gene, 3030 glycoprotein B avian hepatitis B virus surface and core antigen expression amino-terminal synthesis, 1 precore region expression, 3322 antigen characterization, 683 membrane insertion, 1 role in genomic replication, 3322 pre-S and precore influences, 683 synthesis in vitro, 1 ground squirrel and woodchuck hepatitis trans-activating function glycoprotein D expression virus recombinants expression, 3448 cytotoxic T-cell response, 726 infectivity, 3241 localization in X region, 3448 vaccinia virus vector, 726 synthesis of novel viruses, 3241 transfected murine cell line glycoprotein D-specific neutralizing anti- ground squirrel hepatitis virus polyribo- replicative intermediate characteriza- bodies somes and core particles tion, 2921 penetration inhibition, 3356 VOL. 61, 1987 SUBJECT INDEX xvii

glycoprotein E sequences inhibiting transformation, Xgtll expression system, 2454 role in viral infectivity, 600 2989 map locations, 2454 ICP8 deletion mutants transcription initiation sites of ICP8 gene herpes simplex virus type 2 characterization of transformed cell mapping in infected and transfected asymptomatic infections postvaccina- lines, 1136 cells, 615 tion, 264 expression, 1136 US3 open reading frame deletion human cytomegalovirus DNA-binding immediate-early gene growth effect in cell culture, 28% protein regulation by trans-acting factors, 190 protein kinase activity, 28% purification and gene mapping, 3143 sequence requirements, 190 virion stimulatory protein mRNA leader similarity to HSV ICP8, 3143 immediate-early promoters sequences pseudorabies virus gII and herpes sim- expression in HeLa and Vero cells, transcription and mRNA stability role, plex virus type 1 gB genes 2286 2499 homology, 2691 response to trans-acting factors, 2286 virus-specific glycoprotein species pseudorabies virus mutants lacking gly- immediate-early protein ICP0 deletion cell surface expression, 104 coprotein gX mutants flow cytometric analysis, 104 replication and virulence, 229 impaired growth response, 829 Herpes simplex virus type 1 Patton Heterogeneous DNA immediate-early protein ICP4 glycoprotein gBl Epstein-Barr virus palindrome center transcription start site binding, 858 expression in mammalian cells, 315 generation, 1495 immunoglobulin G-binding glycoprotein Herpes simplex virus type 2 sequences, 1495 complex formation with gE, 2208 aphidicolin-resistant mutants Histocompatibility antigens identification, 2208 DNA sequence analysis, 388 human T-cell lymphotropic virus type III inverted repeat sequences of L compo- asymptomatic infections identification, 629 nent detection after vaccination, 264 reovirus type 1 Lang transition to homozygous state, 1187 glycoprotein gB2 gene role in transport into bile, 3222 latently infected mice structure and expression, 326 Horizontal transmission transcript detection, 3841 glycoprotein gG-2 ecotropic murine retroviruses, 1037 mouse footpad and ear skin virulence small-molecular-weight component Host cell gene expression Langerhans cell density role, 2515 cleavage event product, 1735 herpes simplex virus type 1 beta-globin mouse age and genetic strain role, processing and synthesis, 1735 recombinants 2515 ICP4-defective mutants regulation, 2368 virus strain pathogenicity role, 2515 characterization, 1092 Host cell nuclear matrix mutant vhsl isolation, 1092 simian virus 40 stability of immediate-early alpha recurrent infection in guinea pigs association early in infection, 748 mRNAs, 604 biological activity, 2120 Host cell protein synthesis native and recombinant envelope pro- protective immunity regulation, 2120 poliovirus infection teins Herpes simplex virus types 1 and 2 effect of proteolysis of p220, 986 human immune T-cell response, 1532 Epstein-Barr virus and cytomegalovirus mechanism of shutoff, 986, 2480 N-terminal synthetic peptides of glyco- cross-reactivity, 1125 p220 cleavage relationship, 2480 protein D intertypic recombinant RS6 Host shutoff mechanism antipeptide and group VII monoclonal genetic and biological analyses, 1978 herpes simplex virus mutants antibody analyses, 3607 neurovirulence, 1978 function and effects, 2198 structural properties and reactivity, Herpesvirus saimiri mRNA degradation, 2198 3607 subgroups A, B, and N HTLV-III/LAV oriL deletion mutants immortalization in vitro, 3485 human colorectal cell lines latency effect in vivo, 3528 virion protein productive, persistent infection, 209 replication effect in vitro, 3528 Epstein-Barr virus homology, 2063 Human adenovirus type 2 poly(A)+ transcript identification, 2063 cell membrane permeability changes expression in trigeminal ganglia of Herpesvirus suis Na+,K+-ATPase role, 883 mice, 1700 pseudorabies virus Bartha strain Human adenovirus type 5 expression of immediate-early gene location and identification of nucleo- early region 1B 176R protein IE-1, 1700 capsid assembly-defective func- acylation, 3227 rabbit beta-globin clones tions, 7% Human cytomegalovirus cellular gene expression, 2368 Herpesvirus sylvilagus DNA polymerase gene shutoff of host cell expression, 2368 glycoproteins gpl3 and gp32 genomic localization, 119 rabbit trigeminal ganglia antigen identification, 3580 homology with other herpesviruses, detection of latency-related viral characterization, 3580 119, 125 RNAs, 3820 neutralization, 3580 sequence and transcription analysis, reactivation from infected trigeminal Herpesviruses 119, 125 ganglia of mice bovine herpesvirus 1 glycoprotein syn- DNA-binding protein reactivation model, 3288 thesis purification and gene mapping, 3143 replication inhibition by novobiocin gI and gIV vaccine role, 3292 similarity to HSV ICP8, 3143 and coumermycin Al, 3288 temporal control characterization, immediate-early region 2 gene products S component 3292 identification and characterization, DNA synthesis origin, 3349 bovine herpesvirus type 1 latency-re- 3214 open reading frame origin, 3349 lated RNA inducible promoter regulation, 3214 simian virus 40 DNA synthesis characterization, 3827 large structural phosphoprotein gene amplification, 1427 trigeminal ganglia mapping, 3827 pp150 temperature-sensitive mutants bovine herpesvirus type 1 thymidine ki- map position, 1358 complementation by varicella-zoster nase gene nucleotide sequence, 1358 virus, 225 map location, 4023 transcription analysis, 1358 physical mapping of host shutoff loci, equine herpesvirus 1 glycoprotein genes phosphonoacetic acid-resistant mutants 143 detection with monoclonal antibodies, isolation and characterization, 1291 TK+ transformants 2454 phosphoproteins pp65 and pp7l xviii SUBJECT INDEX J. VIROL.

nucleotide sequence, 446 rus Human T-cell leukemia virus type I primary structure and transcription, persistent infection of chimpanzees, p40X protein 446 3173 baculovirus expression vector, 708 Human endogenous retroviruses serological responses and properties, synthesis in eucaryotic cells, 708 HERV-K genome in human tumor cells 3173 Human T-cell lymphotropic virus expression, 2059 Human papillomavirus la human endogenous retroviruslike gen- organization, 2059 Li and L2 open reading frame proteins ome type C pol and gag sequences identification, 2793 evolutionary relationship, 4060 human T-cell lymphotropic virus ho- Human papillomavirus type 1 type C pol and gag sequences, 4060 mology, 4060 RNA transcripts from plantar warts Human T-cell lymphotropic virus type III Human hepatitis delta virus identification and mapping, 1913 histocompatibility antigens woodchuck hepatocyte cultures R-loop characterization, 1913 direct identification, 629 replication, 2891 Human papillomavirus type 6b Human T-lymphotropic virus type III Human immunodeficiency virus Li open reading frame protein art gene protein art gene protein antibody detection, 2684 expression in bacteria, 633 expression in bacteria, 633 identification in condylomas, 2684 brain-derived cell line Human papillomavirus type 11 expression, 1244 laboratory production in vivo, 590 ICP8 mutants cell-mediated immune response Human papillomavirus type 16 herpes simplex virus type 1 characteristics, 2017 cervical carcinoma cell lines characterization of transformed cell conserved domains on envelope glyco- structural and transcriptional analysis, lines, 1136 proteins 962 expression, 1136 serum neutralizing antibody recogni- DNA sequences in SK-v cells Immediate-early antigens tion, 2024 early event in tumor progression, 3295 murine cytomegalovirus cytopathic effects integration, 3295 protective immunity role, 3102 biologic behavior in immortalized E2 gene product Immediate-early gene 1 cells, 1602 long control region analysis, 1630 murine cytomegalovirus cell fusion requirements, 3114 mutational analysis, 1630 sequence, 1901 mechanism of cell killing, 3114 transcriptional trans-activation, 1630 structural organization, 1901 strain differences, 1602 early protein E7 Immediate-early gene 2 envelope glycoproteins biochemical properties, 1686 human cytomegalovirus expression by baculovirus vector, cytoplasmic phosphoprotein identifica- identification and characterization, 3617 tion, 1686 3214 envelope protein sequences function in cancer development, 1686 inducible promoter regulation, 3214 antigenic epitopes in conserved and human fibroblasts and keratinocytes Immediate-early gene expression variable regions, 570 transformation, 1061 herpes simplex virus type 1 vhsl mutant computer-assisted analysis, 570 Human papillomavirus type 18 stability of alpha mRNAs, 604 herpes simplex virus type 1 DNA integration site Immediate-early genes activation of infection, 3726 localization in cervical carcinoma cell Epstein-Barr virus expression histocompatibility antigens line SW756, 1682 P3HR1 superinfection system, 3120 direct identification, 629 E6 and E7 open reading frames herpes simplex virus human colorectal cell lines transforming region localization, 3635 regulation by trans-acting factors, 190 productive, persistent infection, 209 transcriptional promoter sequence requirements, 190 infected T cells characterization, 134 herpes simplex virus effectors azidothymidine treatment effects, 3769 expression by simian virus 40 and ade- alpha promoter response, 3167 replication resumption, 3769 novirus, 134 transcriptional activator response, infectious molecular clones Human papillomavirus types 6 and 11 3167 persistent productive infection in hu- RNA species characterization murine cytomegalovirus man glial cells, 3774 electron microscopic R-loop cytolytic T lymphocytes, 2054 methylation of long terminal repeat se- technique, 2581 host immune response, 2054 quences identification and mapping, 2581 location, transcripts, and translation modulation of gene expression, 1253 Human papillomavirus types 6b ano 16 products, 526 reisolated viruses Li open reading frames Immediate-early IE94 promoters persistent infection of chimpanzees, antigenic properties, 2389 simian and human cytomegaloviruses 3173 expression in E. coli, 2389 nuclear factor 1-binding sites, 1559 serological responses and properties, open reading frame proteins tandem repeat elements, 1559 3173 characterization, 1655 Immediate-early promoters sequence identification DNA-binding activity, 1655 herpes simplex virus type 1 DNA amplification procedure, 1690 Human parainfluenza virus type 3 expression in HeLa and Vero cells, oligonucleotide-based detection, 1690 fusion and hemagglutinin-neuraminidase 2286 superinfection of chimpanzee, 4026 glycoproteins response to trans-acting factors, 2286 T-cell responses by chimpanzees, 3804 contribution to host immunity, 3416 Immediate-early protein ICPO T-cell surface receptors expression by vaccinia virus vectors, herpes simplex virus type 1 deletion mu- downregulation, 3741 3416 tants transmembrane glycoprotein hemagglutinin-neuraminidase glycopro- impaired growth response, 829 antigenic conformation, 2639 tein Immediate-early protein ICP4 immunodominant domain mapping, antigenic structure, 1473 herpes simplex virus type 1 2639 monoclonal antibody selection, 1473 transcription start site binding, 858 Human lymphoid cells sequence analysis of variants, 1473 herpes simplex virus type 2 defective adenovirus types 2 and 5 Human T-cell leukemia virus type 1 mutants productive infection, 1466 p4Ox-responsive regulatory sequences characterization, 1092 Human lymphotropic virus type III identification, 2175 isolation, 1092 reisolated human immunodeficiency vi- trans-activation requirements, 2175 Immediate-early proteins VOL. 61, 1987 SUBJECT INDEX xix

pseudorabies virus Sendai virus infection localization on mouse chromosome 17, binding to single-stranded DNA, 1855 protective effect, 2624 218 pseudorabies virus mutant Infectious hematopoietic necrosis virus Interferon function in early gene transcription, glycoprotein gene cDNA clone adenovirus type 12 early region 1A 1258 nucleotide sequence, 1342 induction, 2326 Immune clearance Infectious pancreatic necrosis virus stimulatory function, 2326 lymphocytic choriomeningitis virus polyprotein, protein, and genome seg- coinfection by adenovirus and vesicular immune therapy, 3920 ment A stomatitis virus studies, 3920 characterization, 3655 modulation by early region 1A, 787 lymphocytic choriomeningitis virus ef- synthesis, 3655 treatment effects, 787 fector cells Infectious process murine cytomegalovirus infection intercell cooperation, 3930 transmissible mink encephalopathy virus genetic resistance, 1875 Immune response extraneural replication, 3235 replication restriction, 1875 anti-idiotypic antibodies to polyomavirus temporal distribution, 3235 RD-114 clonal derivatives monoclonal antibody Influenza A virus different antiviral and gene-inducing infection prevention in mouse kidney major histocompatibility complex class responses, 2727 cells, 2747 I-restricted cytotoxic T lymphocytes Sendai virus duck hepatitis B virus envelope proteins nonstructural protein recognition, 1098 induction by transfection of C gene characterization, 2280 polymerase recognition, 1098 cDNA, 625 comparison of preS and S proteins, reassortant viruses subacute sclerosing panencephalitis 2280 attenuation for primates, 2857 model duck hepatitis B virus-infected ducks Influenza A virus (WSN/33 strain) pathogenic role, 1919 antibody reactivity, 916 matrix (M1) protein vesicular stomatitis and encephalomyo- equine infectious anemia virus functional and antigenic domains, 239 carditis viruses antigenic variation effect, 3783 Influenza virus expression in RD-114 cells, 1524 role, 3783 B-cell mitogenesis treatment effects, 1524 herpes simplex virus type 1 envelope role of hemagglutinin, 214 vesicular stomatitis virus infection in proteins defective interfering particles mice induction in human T cells, 1532 identification in nature, 1517 mechanism for natural resistance, 812 herpes simplex virus type 2 protective effect, 1517 vesicular stomatitis virus transcription asymptomatic infection postvaccina- functional virus envelopes inhibition, 653 tion, 264 membrane and liposome fusion, 2245 v-mos-induced transformation human immunodeficiency virus infection reconstitution, 2245 expression inhibited, 2567 characteristics, 2017 gene expression retroviral RNA down regulation, 2567 interferon-dependent and -independent control mechanisms, early and late, treatment effect, 2567 replication restriction 764 Interferon synthesis genetic resistance, 1875 nuclear-cytoplasmic transport of virus- cytomegalovirus immediate-early IE94 murine cytomegalovirus infection, specific RNAs, 764 promoter 1875 inactivated vaccine stimulation by herpes simplex virus, murine cytomegalovirus antibody induction intragastrically, 819 nonstructural immediate-early antigen 2150 Intra-axonal transport role, 3102 hemagglutinin-specific immunoglobulin Borna disease virus pathogenesis murine cytomegalovirus immediate-early A synthesis, 2150 incubation period, 3431 gene products lymphocyte homing, 2150 route for virus dissemination, 3431 cytolytic T-lymphocyte response, 2054 monoclonal antibody-selected antigenic Intracellular transport murine leukemia virus variants spleen focus-forming virus gpS2 with abrogation of resistance, 383 receptor-binding characteristics, 206 altered membrane domain challenge with ectromelia virus, 383 N9 neuraminidase leukemogenic effect, 4007 persistent mouse rotavirus infection antigenic structure and variation, 2910 Intracisternal A particle genome animal model, 3345 polymerase protein complexes in insect adenovirus type 12 DNA insertion vaccinia virus 39,000-M, protein cells integration in hamster cells, 2719 structure and function, 3910 expression by baculovirus vectors, 361 Intracisternal A particles vaccinia virus recombinants polymerase proteins MIA14 mouse provirus respiratory syncytial virus gene ex- biosynthesis, intracellular localization, comparison with other retroviruses, pression, 3855 and complex formation, 2217 3020 Immune serum PB1 protein expression, 2217 nucleotide sequence, 3020 Epstein-Barr virus DNA polymerase receptor-binding activity of hemaggluti- Inverted repeat sequences antiserum nin molecule herpes simplex virus type 1 L compo- preparation, 3331 antigen-presenting cell activity, 1375 nent rabies virus cell-to-cell spread three polymerase proteins transition to homozygous state, 1187 effect in vitro, 3314 formation of complexes, 16 Invertible long component Immune-stimulating complexes Initiation sites pseudorabies virus vaccine strain Nor- measles virus H and F glycoproteins herpes simplex virus type 1 ICP8 gene den protection, 3896 mapping in infected and transfected evolution, 1772 Immunogenic sites cells, 615 growth advantage in chicken embryo hepatitis A virus int oncogenes fibroblasts, 1772 defined by neutralization escape mu- hormone-dependent and -independent IV.2 promoter tants, 491 mammary tumors adenovirus type 2 mutants Immunogenicity development in GR mice, 1073 RNA synthesis regulation, 646 herpes simplex virus type 1 glycoprotein int-3 locus transcription factor identification, 646 gBl mouse mammary tumor virus integration expression in mammalian cells, 315 region JC virus Immunoglobulin A antibodies identification, 66 owl monkey tumor formation xx SUBJECT INDEX J. VIROL.

multiplication in explanted cells, 1435 Large-T-antigen mutant clearance mechanism studies, 3920 transformed human fetal glial cells simian virus 40 Lyt-2+ T lymphocytes permissivity increased, 755 oligomeric forms, 940 antiviral antibody response, 1867 JHM virus p53 complex formation, 940 recovery mechanism, 1867 adenylate cyclase system influence Large-T-antigen phosphorylation T-cell response, 1571 demyelinating disease models, 3795 polyomavirus Lymphoma incidence expression activation, 3795 effects of viral mutations and cell ecotropic and mink cell focus-forming growth state, 1147 viruses Late gene expression susceptibility of AKXD recombinant Kirsten murine sarcoma virus P22 inbred mice, 2929 synthesis of viral proteins bacteriophage lacZ gene fusion, 3621 Lysosomotropic drugs expression in Escherichia coli, 302 regulation, 3621 reovirus outer capsid proteins vaccinia virus NH4CI effect on viral growth, 2351 L protein expression regulation, 639 vesicular stomatitis virus Late gene transcription homotypic and heterotypic exclusion, polyomavirus-transformed rat cells Macrophage-resistant cells 3133 reiterated leader sequence function, simian virus 40-transformed fibroblasts La Crosse virus 4055 gp7O expression, 928 cryoelectron microscopic technique Latency disruption Major capsid antigen VP6 structural features, 2319 Epstein-Barr virus polymorphic proteins simian rotavirus SAl1 recombinant S-mRNA synthesis BZLF1 role, 3672 baculovirus expression system, 1488 in vitro translational requirement, 87 Latency-related RNAs synthesis and immunogenicity, 1488 in vivo translational requirement, 96 bovine herpesvirus type 1 Major capsid protein VP1 translational requirement model, 3960 trigeminal ganglia mapping, 3827 polyomavirus genome S-mRNA transcripts Latent infection modification by tyrosine sulfuration, nucleocapsid assembly sites, 667 herpes simplex virus 1708 Xgtll expression system nerve growth factor deprivation effect, Major histocompatibility complex class I equine herpesvirus 1 glycoprotein genes 2311 adenovirus type 35 antigen-binding gly- detection with monoclonal antibodies, herpes simplex virus type 1 in rabbits coprotein 2454 latency-related viral RNA detection, characterization, 3665 map locations, 2454 3820 anti-influenza virus cytotoxic T lympho- Large T antigen herpes simplex virus type 1 oriL deletion cytes polyomavirus mutants nonstructural protein recognition, 1098 expression by baculovirus vector, establishment and reactivation effect, polymerase recognition, 1098 1712 3528 Major histocompatibility complex class II polyomavirus phosphorylated subclasses herpes simplex virus type 1-infected simian immunodeficiency virus measurement, 2336 mice expression in vitro, 1421 nuclear association, 2336 transcript detection, 3841 Marek's disease herpesvirus polyomavirus phosphorylations Latent membrane protein gene encoding A antigen polypeptide localization, 1155 Epstein-Barr virus-encoded p63/LMP identification, 2614 polyomavirus-mouse hybrid replicon processing, 2100 Mason-Pfizer monkey virus RmI resolution function, 845 Leader RNA synthesis myristylation mutation simian virus 40 vesicular stomatitis virus replication role in intracellular transport and as- cellular secretory pathway role, 3950 cytopathogenicity in Drosophila cells, sembly, 1045 DNA replication increased, 3373 1391 Matrix (MI) protein DNA-binding activity, 2076 Lentiviruses influenza A virus (WSN/33 strain) oligomerization, 2076 visna virus transcriptional pattern functional and antigenic domains, 239 phosphatase treatment effect, 3373 significance, 1325 Measles virus synthesis and processing, 3950 Leukemogenicity B-cell cycle of infection tumor formation in transgenic mice, Friend-mink cell focus-forming and Mo- immunoglobulin secretion block, 3441 2029 loney murine leukemia viruses sequence of events, 3441 simian virus 40 cytoplasmic-localization enhancer sequence roles, 1861 H and F glycoproteins mutant pSVCT3 murine retroviral long terminal repeats protection by immune-stimulating transformation of precrisis human transcriptional tissue specificity, 1067 complexes, 3896 cells, 3521 Lymphadenopathy-associated virus membrane protein mRNA simian virus 40 DNA replication reisolated human immunodeficiency vi- selective inhibition of translation, 472 monoclonal antibody probes, 411 rus phosphoprotein and matrix protein simian virus 40 infection persistent infection in chimpanzees, structure and function of bicistronic subnuclear distribution analysis, 3561 3173 RNA, 584 simian virus 40 mutant serological responses and properties, ribonucleoprotein complexes trans-activation of cellular and viral 3173 RNA synthesis analysis, 3381 promoters, 1296 Lymphadenopathy-associated virus type 1 transcription system, 3381 simian virus 40 origin binding human immunodeficiency virus type subacute sclerosing panencephalitis ATP enhancement of DNA replica- ARV-2 model tion, 3649 chimpanzee superinfection, 4026 interferon resistance, 1919 simian virus 40 origin-specific Lymphocytic choriomeningitis virus pathogenesis, 1919 DNA-binding domain clearance mechanism studies Medium T antigen analysis, 3326 cooperation between cells, 3930 polyomavirus proteins simian virus 40 trans-dominant defective GP-C glycoproteins interactions, 3902 mutants cleavage site conservation, 982 Membrane antigen characterization, 436 definition by site-specific antibodies, Epstein-Barr virus simian virus 40-transformed human cells 982 herpesvirus saimiri homology, 2063 spontaneous mutant expression, 2864 immune therapy of persistent infection identification, 2063 VOL. 61, 1987 SUBJECT INDEX xxi

Membrane protein tumorigenic properties, 2530 D measles virus mRNA translation Rous sarcoma virus p60v-src domains neutralizing antibodies inhibit penetra- restricted synthesis, 472 investigation, 1678 tion, 3356 Membrane protein BNLF-1 Moloney and Friend murine leukemia vi- herpes simplex virus type 1 glycoprotein Epstein-Barr virus ruses D N-terminal synthetic peptides expression in transformed cells, 866 U3 region sequences antipeptide antibody analysis, 3607 posttranslational processing, 866 disease specificity determinants, 693 structural properties and reactivity, Methylation patterns Moloney murine leukemia virus 3607 adenovirus type 2 E2A promoter Dsi-J frequent integration region human parainfluenza virus type 3 hemag- gene expression, 3710 isolation from rat thymomas, 1164 glutinin-neuraminidase glycoprotein stability, 3710 embryonal carcinoma cell system antigenic structure, 1473 3-Methylquercetin gene expression, 2742 sequence analysis of variants, 1473 poliovirus RNA replication sequence element mediation, 2742 human rotavirus VP3 protein inhibition selectively, 3319 env message antigenic variant analysis, 1726 MIA14 mouse provirus cDNA clone sequence, 2038 cross-reactive neutralization epitopes, intracisternal A-particle genome splice acceptor site, 2038 1726 comparison with other retroviruses, Friend-mink cell focus-forming virus re- influenza virus N9 neuraminidase 3020 combinants antigenic structure and variation, 2910 nucleotide sequence, 3020 enhancer sequence roles, 1861 influenza virus variants Middle surface protein leukemogenicity, 1861 receptor-binding characteristics, 206 hepatitis B virus gag region synthesis pp60v-src, pp70v-fgr, and ppgov-Yes tyrosine antibodies to pre-S and S epitopes, packaging signal involvement, 1639 kinase activity 1286 long terminal repeat inhibition, 1927 expression by vaccinia virus recombi- role in Abelson virus-induced lym- rabies virus nant, 1286 phoma, 3266 role in in vitro cell-to-cell spread, 3314 Middle T antigen long terminal repeat recombinants scrapie-associated fibril proteins adenovirus expression system tissue-specific replication, 1350 antibody response in mice, 3688 characterization, 1221 long terminal repeats Sendai virus immunoglobulin A antibod- dihyrofolate reductase expression, DNase I-hypersensitive site analysis, ies 1213 1368 protective effect, 2624 adenovirus vector significance, 1368 simian virus 40 DNA replication overproduction, 1226 myeloid tumors in BALB/c mice large T-antigen function, 411 polyomavirus transformation c-myb activation requirement, 3721 Theiler's murine encephalomyelitis virus cooperation with small T antigen, 2253 v-abl involvement lacking, 3721 anti-A-IS treatment effect, 898 polyomavirus transformation-defective promoter sequences timing importance of treatment, 898 mutant expression in embryonal cells, 3248 vaccinia virus cell fusion association with 73-kilodalton heat proviral integration sites formation of covalently linked trimers, shock protein, 405 DNase-hypersensitive chromatin, 336 395 polyomavirus-transformed cell lines integration and structure, 336 role of 14,000-M, envelope protein, transcription changes, 2448 replication-defective mutants 395 polyomavirus-transformed rat cells endonuclease activity characterization, Morphf mutants analysis, 3299 1756 Rous sarcoma virus pp6(C-src interactions, 3299 retroviral vector internal viral sequences nucleotide sequence analysis, 1893 polyomavirus-transformed variants effect, 1647 v-src lesion localized, 1893 characterization, 1079 utility, 1647 mos oncogene pp60Csrc expression, 1079 RNase H activity myeloproliferative sarcoma virus tem- Middle-T binding site plus-strand primer formation, 2843 perature-sensitive mutants polyomavirus Moloney murine sarcoma virus activity, 889 mapping interactions with pp6OC-src, v-mos gene expression Mouse hepatitis virus 285 biological and biochemical analysis, 5'-end genomic RNA Mill Hill 2 virus 3625 RNA polymerase structure, 3968 v-mil oncogene P55 and vimentin identification, 3625 sequence and translation, 3968 fibroblast transformation parameters, Monoclonal antibodies Mouse hepatitis virus A59 1717 anti-idiotypic antibodies to polyomavirus glycoprotein El homology with v-raf, 1717 monoclonal antibody Golgi region localization, 2042 v-mil sequences infection prevention in mouse kidney structural protein N propagation in vivo or in vitro, 1949 cells, 2747 replication in vitro, 1814 Mink cell focus-forming murine leukemia bovine virus diarrhea virus clones virus-binding activity viruses bovine enterovirus-3 inhibition, 2050 genetic resistance, 185 AKXD recombinant inbred mice cellular p220 in poliovirus-infected cells Mouse mammary tumor virus characterization, 2929 characterization, 2702 hormone-dependent and -independent lymphoma susceptibility, 2929 distribution and conformer identifica- tumors virus-related transcripts tion, 2702 activation of int oncogenes, 1073 expression in AKR mice, 876 Epstein-Barr virus EBNA-5 development in GR mice, 1073 xenotropic virus and proviral genes multiple protein species detection, integration region int-3 env gene probes, 3082 3870 localization on mouse chromosome 17, wild mouse origins, 3082 equine herpesvirus 1 glycoprotein genes 218 Mitogenic activity Agtll expression system, 2454 long terminal repeat influenza virus map locations, 2454 expression in transgenic mice, 3013 role of hemagglutinin, 214 equine infectious anemia virus variants simian virus 40 marker gene, 3013 Rous sarcoma virus mutant dIPA105 antigenic analysis, 2956 nomenclature proposed, 1651 cell-type-specific response, 2530 glycoprotein gp9O epitopes, 2956 recombinant DNA clones p45v-src protein isolation, 2523 herpes simplex virus type 1 glycoprotein comparison with other retroviruses, xxii SUBJECT INDEX J. VIROL.

480 Sendai virus lethal infection lack of genetic transmission, 2225 nucleotide sequence, 480 linkage to resistance/susceptibility, Mutants Mouse mammary tumor virus (Czech II) 1670 herpes simplex virus type 1 glycoprotein tumorigenesis in feral mice Muramidase E int-3 locus identification, 66 bacteriophage Cp-1 lysin role in infectivity, 600 mRNA cap site biochemical characterization, 2573 Mutational analysis herpes simplex virus type 1 leader se- cloning and purification, 2573 bovine papillomavirus type 1 open read- quences Murine cytomegalovirus ing frame E4 transcription and stability role, 2499 adoptive cellular immunity biological activities, 1248 mRNA degradation modification of adrenalitis, 23 late gene expression, 1248 herpes simplex virus mutants immediate-early gene 1 Mutations function and effects, 2198 sequence and structural organization, poliovirus type 3 recombinant host shutoff mechanism, 2198 1901 neurovirulence model in mice, 2917 mRNA expression immediate-early gene products myb oncogenes ERV3 human endogenous retrovirus cytolytic T-lymphocyte recognition, c-myb gene insertion sequence analysis, 2182 2054 murine leukemia virus truncation, mRNA induction host immune response, 2054 2339 interferon treatment immediate-early genes myeloid cell line derivation, 2339 expression in RD-114 cells, 1524 location, transcripts, and translation myb RNAs mRNA metabolism products, 526 retroviral insertion in murine monocytic adenovirus type 5 ribonucleoproteins interferon-dependent and -independent leukemias association with hnRNA in infected replication restriction altered transcript induction, 2754 cells, 3276 genetic resistance, 1875 characterization, 2754 mRNA processing nonstructural immediate-early antigen c-myb rearrangement, 2754 adenovirus E3 region deletion mutants protective immunity role, 3102 myc oncogene deleted sequence function, 3938 peritoneal macrophage infection feline leukemia virus variant role, 3938 comparative study, 3602 activity in early-passage cells in vitro, mRNA sequence H-2-determined sensitivity, 3602 3072 infectious hematopoietic necrosis virus Murine leukemia provirus transforming potential, 3072 cDNA clone germ line integration into retroviruslike myc transformation comparison of vesicular stomatitis vi- sequence avian myelocytomatosis virus MC29 rus and rabies virus sequences, long terminal repeat analysis, 701 characterization, 2138 1342 sequence analysis, 701 quail macrophage transformation, 2138 glycoprotein gene sequence, 1342 Murine leukemia virus myc-associated proviruses mRNA species Akvr-J restriction gene 5' long terminal repeat impairments bovine papillomavirus type 1 transform- characterization, 308 avian leukosis virus tumors, 2489 ing region challenge with ectromelia virus Mycoplasma viruses L2 and L2insl processing sites, 2240 abrogation of resistance, 383 DNA replication origins and termini promoters, 2240 class II polytropic MuLVs mapping, 1909 mRNA splicing class I generation, 1882 Myeloid cell lines Rous sarcoma virus env and src genes role, 1882 c-myb gene insertion efficiency of noncoding region, 177 envelope glycoprotein processing derivation, 2339 mRNA synthesis Arg-to-Lys mutation role, 2852 murine leukemia virus truncation, influenza virus polymerase proteins integration-deficient mutant 2339 complex formation in insect cells, 361 oligomeric retroviral DNA integration, Myeloproliferative leukemia virus expression by baculovirus. vectors, 361 1964 acute leukemogenic replication-defective role of nucleocapsid protein ras-containing isolates retrovirus complexes, 16 biologic and molecular characteriza- genetic analysis, 579 simian virus 40 mutant tion, 2109 Myeloproliferative sarcoma virus agnoprotein production, 2331 comparison with other ras oncogenes, temperature-sensitive mutants translation initiation effect, 2331 2109 activity, 889 vesicular stomatitis virus retroviral insertion in c-myb gene mos oncogene point mutation, 889 inhibition by interferon, 653 myeloid cell line derivation, 2339 Myristylation mRNA transcript truncation, 2339 D-type retrovirus capsids herpes simplex virus type 1 retroviral long terminal repeats required for intracellular transport, immediate-early gene IE-1 expression, transcriptional tissue specificity, 1067 1045 1700 transcriptional control region Myxoma virus mRNA transcription glucocorticoid regulation, 269 epidermal growth factor and transform- La Crosse virus S genome viral enhancer region, 269 ing growth factor alpha genes nucleocapsid assembly sites, 667 Murine leukemia virus-related endogenous mapping and sequencing, 1271 mink cell focus-forming murine leukemia proviruses virus-related transcripts classification expression in AKR mice, 876 recombination potential, 2659 N9 neuraminidase visna virus structural relationships, 2659 influenza virus expression pattern, 1325 Murine mink cell focus-forming virus antigenic structure and variation, 2910 mRNA translation env gene linked to Rcmf locus monoclonal antibody inhibition, 2910 measles virus membrane protein identification of two forms, 29 Na+,K+-ATPase selective inhibition of translation, 472 Murine monocytic leukemia cell lines adenovirus-dependent cell membrane poliovirus-induced host cell shutoff c-myb gene rearrangement permeability changes in vitro model, 2480 induction, 2754 role, 883 p22 cleavage relationship, 2480 RNA species characterization, 2754 Natural killer cells reovirus sigma 3 protein role, 2472 Mus germ line adenovirus type 2-transformed cells Mucociliary transport polymorphism amphotropic env-specific proviral DNAs lysis, 2155 VOL. 61, 1987 SUBJECT INDEX xxiii

tumor susceptibility of athymic ro- mouse cells sequence identification, 1690 dents, 2155 reactivation inhibition, 3288 Oncogene chimera adenovirus types 2 and 5 ElA gene Nuclear antigen complex v-erbB/src fusion polypeptide products Epstein-Barr virus analysis, 1938 cytolytic susceptibility, 3510 DNA-binding site, 465 biochemical and biological properties, Friend virus-induced erythroleukemoge- high concentration dependence, 465 1938 nesis Nuclear antigen EBNA 2 Oncogene expression stem cell suppression, 2631 Epstein-Barr virus Abelson murine leukemia virus lympho- Neomycin B-cell growth phenotype influence, magenesis herpes simplex virus type 1 1310 clonal dominance and progression, polypeptide inhibition, 3388 Nuclear antigen EBNA3 2192 receptor-binding effect, 3388 Epstein-Barr virus gene murine gamma interferon treatment Neoplastic diseases mapping, 3340 v-mos-induced transformation inhibi- avian leukosis virus subgroup F recom- overexpression by using adenovirus tion, 2567 binants vector, 3340 Oncogenes induction, 1203 Nuclear antigen EBNA-5 gag-erbB fused gene sequence identification, 1203 Epstein-Barr virus multiple antigen spe- transforming ability, 1665 Nerve growth factor cies Kirsten murine sarcoma virus herpes simplex virus monoclonal antibody detection, 3870 expression in Escherichia coli, 302 latency in vitro, 2311 Nuclear localization synthesis of viral proteins, 302 Neurovirulence simian virus 40 VP2 and VP3 polypep- Orbiviruses herpes simplex virus types 1 and 2 inter- tides bluetongue virus typic recombinant RS6 identification of sequence role, 3862 genome segment reassortment, 2670 genetic and biological analyses, 1978 Nuclear matrix oriL deletion mutants Neutralizing antibodies adenovirus replication herpes simplex virus type 1 human immunodeficiency virus alterations in structure, 1007 latency effect in vivo, 3528 conserved domains Nuclear phosphoprotein replication effect in vitro, 3528 recognition, 2024 bovine leukemia virus X region Ovine lentiviruses respiratory syncytial virus infection in expression, 1577 replication and cytopathic effects cotton rats Nuclear proteins pathogenicity correlation in vivo, 4038 parenteral treatment effect, 1851 adenovirus type 2 Ela region topical treatment effect, 1851 differential localization, 247 P38 promoter Neutralizing regions Epstein-Barr virus bicistronic mRNA parvovirus H-1 feline leukemia virus envelope gene identification and analysis, 945 tar element characterization, 2807 anti-synthetic peptide antibodies, 8 herpes simplex virus ICP4 trans-activation, 2807 Nickel-induced revertants localization, 276 p40X protein retroviral gene expression Nucleocapsid assembly human T-cell leukemia virus type I characterization, 2378 La Crosse virus baculovirus expression vector, 708 NK24 virus S-mRNA transcripts, 667 synthesis in eucaryotic cells, 708 chicken c-fos proto-oncogene pseudorabies virus Bartha strain p4Ox gene product cloning, 4012 location and identification of defective human T-cell leukemia virus type 1 long nucleotide sequence and analysis, genomes, 796 terminal repeat 4012 Nucleocapsid protein gene regulatory sequence identification, v-fos oncogene vaccinia viruses carrying respiratory 2175 characterization, 3733 syncytial virus N gene trans-activation requirements, 2175 Nomenclature transcription and translation products, p45v-src protein endogenous mouse mammary tumor vi- 2885 Rous sarcoma virus mutant dIPA105 ruses, 1651 vaccine efficacy, 2885 cell-type-specific response, 2530 Noncapsid proteins Nucleocapsid structure characterization and sequence, 2523 parvovirus B19 bacteriophage 46 isolation, 2523 characterization, 2627 RNA segment analysis, 2362 tumorigenic properties, 2530 5' Noncoding region Nucleoprotein antigen p48v-myb expression poliovirus type 1 Sabin strain mutants anti-vesicular stomatitis virus cytotoxic avian erythroblastosis virus-transformed replication function, 1478 T lymphocytes erythroblasts Nonstructural proteins bm3 mutant recognition, 1992 effect on c-myb expression, 3284 bluetongue virus NS2 protein Nucleoprotein gene p48v-myb transformation phosphorylation and purification, 3589 avian influenza virus reassortants avian myeloblastosis virus deletion mu- single-stranded RNA affinity, 3589 attenuation for primates, 2857 tant bovine parvovirus Nucleoside triphosphate phosphohydrolase env-encoded residue unnecessary, 933 homology with NS-1 proteins of other I p53 oncogene autonomous parvoviruses, 3612 vaccinia virus gene multistage Friend erythroleukemia identification, 3612 identification, 1738 genomic rearrangements, 2777 dengue virus proteins independent origin of tumor clones, expression by recombinant vaccinia Octyl-P-D-glucopyranoside 2777 virus, 4019 polyomavirus receptor moieties p60v src domains feline panleukopenia virus extraction from mouse kidney cell sur- Rous sarcoma virus expression in E. coli, 621 faces, 375 mitogenic activity, 1678 multiple forms in infected cells, 621 2',5'-Oligoadenylate myristylation, 1678 parvovirus H-1 trans-activation encephalomyocarditis virus-infected p63/LMP protein cytotoxic expression, 1448 mice Epstein-Barr virus genetic switch construction, 1448 accumulation, 1586 processing, 2100 Novobiocin and coumermycin Al Oligomer cleavage p220 cleavage herpes simplex virus type 1-infected human immunodeficiency virus poliovirus proteinase 2A xxiv SUBJECT INDEX J. VIROL.

eucaryotic initiation factor 4F alter- E7 ORFs core antigen expression, 955 ation, 2711 transforming function localization, Phosphoprotein pplS0 translation in vitro, 2711 3635 human cytomegalovirus p220 polypeptide human papillomavirus types 6 and 11 map position, 1358 subcellular distribution in poliovirus- mRNAs nucleotide sequence, 1358 infected cells electron microscopic R-loop transcription analysis, 1358 conformer identification, 2702 technique, 2581 Phosphoproteins pp65 and pp7i monoclonal antibody-aided character- RNA species identification and map- human cytomegalovirus ization, 2702 ping, 2581 nucleotide sequence, 446 Packaging specificity human papillomavirus types 6b and 16 primary structure and transcription, reticuloendotheliosis virus/murine leuke- Li ORFs 446 mia virus recombinant vectors antigenic properties, 2389 Phosphorylation characterization, 2675 expression in E. coli, 2389 bluetongue virus nonstructural protein replication enhancement effect, 2675 open reading frame proteins NS2 Papillomaviruses characterization, 1655 analysis, 3589 bovine papillomavirus proteins DNA-binding activity, 1655 purification, 3589 analysis, 3596 reindeer papillomavirus E5 region poliovirus-infected HeLa cells bovine papillomavirus type 1 characterization, 3394 cellular protein kinase activation, 1781 mutational analysis of 3' ORFs, 3889 comparison with other papillomavi- eucaryotic initiation factor-2 inhibi- RNA levels and protein expression, ruses, 3394 tion, 1781 2924 transforming properties, 3394 Picornaviruses tumorigenicity in hamster cells, 2924 Papovaviruses aphthovirus type 01 strain Campos at- bovine papillomavirus type 1 E region hamster papovavirus-induced tenuated and virulent recombinants promoters lymphomas isolation and characterization, 419 identification, 2240 DNA cloning and sequencing, 3992 encephalomyocarditis virus VP3/VP1 processing sites, 2240 polyomavirus structural protein VP1 cleavage site mutations cottontail rabbit papillomavirus E6 poly- host cell influence, 509 capsid precursor assembly disruption, peptides Parvovirus B19 3680 early region transcription, 2938 capsid and noncapsid proteins processing effect, 3680 identification, 2938 characterization, 2627 foot-and-mouth disease virus infection enhancers and E2 transcriptional factors Parvovirus H-1 treatment with ribavirin, 233 identification, 2599 inducible trans-activation of genes wild-type hepatitis A virus sequence human papillomavirus la late proteins cytotoxic expression, 1448 comparison with different strains, 50 identification, 2793 genetic switch construction, 1448 comparison with other picornaviruses, Li and L2 open reading frame pro- Parvoviruses 50 teins, 2793 adeno-associated virus hydroxyurea-pre- pol domain human papillomavirus 18 transcriptional treated cells avian sarcoma and leukosis viruses promoter helper-independent replication, 972 processing, 534 characterization, 134 Aleutian disease virus infection in mink pol-endo gene modulation of expression by simian kits avian sarcoma and leukosis viruses virus 40 and adenovirus, 134 sequential development, 81 cleavage and gorwth sites, 1999 human papillomavirus type 1 plantar B19 parvovirus long terminal repeat (LTR)-LTR junc- wart isolates novel transcription map, 2395 tion, 1999 R-loop characterization, 1913 bovine parvovirus nonstructural proteins Poliovirus RNA transcript identification and homology with NS-1 proteins of other 55S particles mapping, 1913 autonomous parvoviruses, 3612 assembly sequence, 561 human papillomavirus type 6b Li open identification, 3612 role in morphogenesis, 561 reading frame protein densovirus sequence and organization cellular p220 cleavage antibody detection, 2684 homology with densovirus and depen- monoclonal antibody-aided character- identification in condylomas, 2684 dovirus, 553 ization, 2702 human papillomavirus type 11 host-dependent evolution, 553 subcellular distribution and conformer laboratory production, 590 feline panleukopenia virus nonstructural identification, 2702 human papillomavirus type 16 cervical protein host cell shutoff carcinoma cell lines expression in E. coli, 621 mRNA translation restriction, 2480 structural and transcriptional analysis, multiple forms in infected cells, 621 p220 cleavage relationship, 2480 962 parvovirus H-1 P38 promoter inhibition of host protein synthesis human papillomavirus type 16 DNA se- tar element characterization, 2807 mechanism of shutoff, 986 quences trans-activation, 2807 role of proteolysis of p220, 986 integration, 3295 Pathogenesis P1 precursor human papillomavirus type 16 E2 gene Borna disease virus infection cleavage to capsid proteins, 3181 product incubation period, 3431 processing determinants, 3181 long control region analysis, 1630 intra-axonal transport, 3431 phosphorylation levels in HeLa cells transcriptional trans-activation, 1630 rabies virus cellular protein kinase activation, 1781 human papillomavirus type 16 protein axonal transport in vitro, 2733 eucaryotic initiation factor-2 inhibi- E7 cultured rat sensory neuron infection, tion, 1781 cytoplasmic phosphoprotein identifica- 2733 RNA polymerase tion, 1686 Phosphate content host factor-induced template modifica- role in cancer development, 1686 polyomavirus large T antigen tion, 802 human papillomavirus type 18 DNA in- determination in phosphorylated sub- synthesis, 802 tegration classes, 2336 RNA polymerase 110 subspecies localization in cervical carcinoma cell nuclear association, 2336 modification after infection, 1002 line SW756, 1682 Phosphocore analysis RNA polymerase purification human papillomavirus type 18 E6 and hepatitis B virus characterization of product RNAs, 611 VOL. 61, 1987 SUBJECT INDEX xxv

chromatography on hydroxylapatite or large-T-antigen phosphorylation murine retroviral expression vector poly(U) Sepharose, 611 effects of viral mutations and cell cDNA clone generation, 1731 RNA replication growth state, 1147 polyomavirus-transformed rat cells 3-methylquercetin selective inhibition, late gene transcription in rat cells interactions, 3299 3319 reiterated leader sequence role, 4055 middle T antigen analysis, 3299 snapback double-stranded RNA major capsid protein VP1 pp60c-sr activity isolation from HeLa cells, 2307 modification by tyrosine sulfuration, polyomavirus middle T-antigen-trans- poly(A) deficiency, 2307 1708 formed variants Poliovirus proteinase 2A medium T-antigen-associated proteins characterization, 1079 eucaryotic initiation factor 4F polypep- interactions, 3902 expression levels, 1079 tide p220 middle T antigen and dihydrofolate re- pp60v-rc protein cleavage induced, 2711 ductase Rous sarcoma virus-transformed cells translation in vitro, 2711 expression in adenovirus recombinant, forms, 1593 Poliovirus replicase 1213 Pre-C region dimeric RNA molecules middle T-antigen overproduction duck hepatitis B virus primer-dependent synthesis, 2997 adenovirus vector, 1226 core protein synthesis and secretion, Poliovirus type 1 middle T-antigen-transformed variants 3701 crude replication complexes characterization, 1079 function, 3701 RNA synthesis in vitro, 2816 pp0Cs-Irc expression, 1079 PreS proteins intratypic recombinants middle tumor antigen duck hepatitis B virus envelope proteins crossing-over sites on viral genome, analysis in transformed rat cells, 3299 biochemical and immunological char- 1722 pp6jC-sr interactions, 3299 acterization, 2280 proteinase 3C mutants middle-T binding site for pp60Csrc comparison with S protein, 2280 RNA polymerase synthesis deficiency, mapping amino-terminal half, 285 PreSl protein 2162 receptor moieties from mouse kidney hepatitis B virus site-directed mutagenesis, 2162 cell surfaces acylation with myristic acid, 1672 VP1 viral capsid protein extraction with expression in mammalian cells, 1672 neutralizing antibody induction, 1442 octyl-3-D-glucopyranoside, 375 hepatitis B virus major surface antigen production in Escherichia coli, 1442 regulatory region mutants regulation of secretion, 782 Poliovirus type 1 Sabin strain replicative cis-advantage, 1615 Prion rods viable deletion and insertion mutants RmI chimera scrapie-associated fibrils construction, 1478 site-specific recombination, 840, 845 immunodecoration, 42 5' noncoding region function, 1478 viral DNA release, 840 protease-resistant protein, 42 Poliovirus type 3 structural protein VP1 Prions antigenic sites host cell influence, 509 scrapie inactivated virus vaccine implications, transformation of established cell lines resistance to UV irradiation, 159 3749 middle- and small-T-antigen coopera- proal(I) collagen gene modification by host enzymes, 3749 tion, 2253 retroviral-vector-mediated transfer mouse-adapted-human recombinant transformation-defective mutant Mov-13 mouse strain model, 2549 neurovirulence model, 2917 association with 73-kilodalton heat type I collagen-deficient phenotype Polymerase genes shock protein, 405 rescue, 2549 human and avian influenza virus constel- middle T antigen, 405 Prohead core lation transformed cell lines bacteriophage T4 head assembly path- attenuation for primates, 2857 transcription changes, 2448 way Polymerase proteins tumor induction in mice maturation, 113 influenza virus genetic determinants, 2232 Protease activity complex formation in insect cells, 361 noncoding and coding region influ- infectious pancreatic necrosis virus poly- expression by baculovirus vectors, 361 ences, 2232 protein formation of complexes, 16 VP1 capsid protein characterization, 3655 influenza virus-infected cells calcium localization, 2934 tobacco etch virus polyprotein biosynthesis, intracellular localization, Polyomavirus transformants characterization, 2540 and complex formation, 2217 normal cell proliferation blocked gene mapping, 2540 PB1 protein expression, 2217 cyclic AMP effect, 1546 Protease-resistant proteins vesicular stomatitis virus recombinant L Polyomavirus virion proteins scrapie-associated fibril proteins protein kinetics of association of VP1, VP2, and antibody response in mice, 3688 homotypic and heterotypic exclusion, VP3 Protein kinase activity 3133 expression by vaccinia virus vector, herpes simplex virus type 1 US3 dele- Polyomavirus 516 tion anti-idiotypic antibody production subcellular distribution of proteins, effect in cell culture, 2896 infection prevention in mouse kidney 516 pk gene function, 2896 cells, 2747 Polytropic murine leukemia viruses Proteinase 3C early region alternative poly(A) site class II polytropic MuLVs poliovirus mutants altered splicing pattern, 3754 class I generation role, 1882 RNA polymerase synthesis deficiency, 3'-end heterogeneity, 3754 Potyviruses 2162 JC virus mutants tobacco etch virus polyprotein site-directed mutagenesis, 2162 permissivity of transformed human gene mapping, 2540 Proto-oncogenes fetal glial cells, 755 proteolytic processing, 2540 mouse mammary tumor virus (Czech large T antigen Poxvirus telomeres I)-induced tumors expression by baculovirus vector, Shope fibroma virus core target int-3 locus identification, 66 1712 sequence Pseudorabies virus nuclear association, 2336 resolution, 1957 attenuated vaccine strain (Norden) phosphorylated subclasses, 2336 vaccinia virus symmetry, 1957 growth advantage in chicken embryo phosphorylation localization, 1155 pp6Oc-srC fibroblasts, 1772 xxvi SUBJECT INDEX J. VIROL.

invertible long component, 1772 sequence, 2091 tors gll gene Regulatory regions packaging specificity, 2675 homology with herpes simplex virus polyomavirus mutants replication enhancement effect, 2675 type 1 gB gene, 2691 effects on growth, 1615 Retrotransposons glycoprotein glll replicative cis-advantage, 1615 endogenous retrovirus localization and modification, 2962 Rous sarcoma virus env and src genes 3' long terminal repeat as transcription mutants with unique EcoRI sites, 2962 splicing efficiency, 177 promoter, 1261 glycoprotein gp5O as a subunit vaccine vaccinia virus late promoter tRNAFOr primer-binding site evaluation, 3977 DNA replication, 75 characterization, 2071 immediate-early protein vesiculoviruses synthetic oligonucleotide probe, 2071 adenovirus type 5 ElA coinfection, genome RNA terminus conservation Retroviral DNA integration 1103 and diversity, 200 murine leukemia virus integration-defi- binding to single-stranded DNA, 1855 Regulatory sequences cient mutant transcription of class II and class III human T-cell leukemia virus type 1 long oligomeric form, 1964 genes, 1103 terminal repeat Retroviral gene expression immediate-early protein function identification, 2175 nickel-induced revertants role in early gene transcription, 1258 p4Ox trans-activation, 2175 characterization, 2378 mutants lacking glycoprotein gX simian virus 40 late promoter Retroviral insertions replication and virulence, 229 characterization, 167 c-myb gene in murine monocytic leuke- ribonucleotide reductase Reindeer papillomavirus mias biochemical properties, 2046 E5 region RNA species characterization, 2754 viral polypeptide identification, 2046 characterization, 3394 transcript rearrangement, 2754 structural glycoprotein comparison with other papillomavi- Retroviral loci virulence role, 4030 ruses, 3394 murine leukemia virus Pseudorabies virus Bartha strain transforming properties, 3394 characterization of Akvr-J restriction glycoprotein gI Reovirus type 1 Lang gene, 308 role in virus release, 2764 major histocompatibility complex class Retroviral oncogenes nucleocapsid assembly-defective func- II antigen feline c-fes/fps proto-oncogene tions transport into bile, 3222 comparison with related oncogenes, location and identification of genome, Reovirus type 3 2009 796 sigma 3 protein structure, 2009 ptg mutations translation in infected L cells, 2472 Retrovirus expression vector bacteriophage T4 Reovirus type 3 (Dearing) pp6Oc-src cloning DNA sequence analysis, 2828 sialylated glycoproteins expression, 1731 localization in gene 23, 2823 attachment protein mediation, 1407 Retrovirus integration phenotypes, 2835 binding inhibition, 1407 Moloney murine leukemia virus sigma 1 protein DNase-hypersensitive chromatin, 336 Rabies virus composition, 1834 proviral integration sites, 336 cultured rat sensory neurons multimeric form identified, 1834 Retrovirus packaging signal axonal transport in vitro, 2733 Reoviruses Moloney murine leukemia virus vectors in vitro cell-to-cell spread bluetongue virus gag region inclusion, 1639 antiglycoprotein monoclonal antibody genome segment reassortment, 2670 Retrovirus recombination inhibition, 3314 outer capsid protein digestion Rous sarcoma virus packaging mutant immune serum effect, 3314 infectious cycle role, 2351 TK15 variants ras-containing mufine leukemia viruses NH4Cl effect, 2351 analysis, 3209 murine sarcoma virus isolates Replication-defective retrovirus Retrovirus vectors biologic and molecular characteriza- myeloproliferative leukemia virus F9 embryonal carcinoma cells tion, 2109 genetic analysis, 579 gene expression, 3248 comparison with other ras oncogenes, Respiratory syncytial virus human proal(I) collagen gene 2109 neutralizing antibody treatment Mov-13 mouse strain model, 2549 RD-114 cell line parenteral treatment effect, 1851 type I collagen-deficient phenotype clonal derivatives topical treatment effect, 1851 rescue, 2549 different antiviral and gene-inducing recombinant vaccinia virus vectors internal viral sequences responses, 2727 F protein expression, 293 effect on utility, 1647 interferon response, 2727 protection of vaccinated mice, 293 large direct repeats Reassortment subgroups A and B deletions, 925 bluetongue virus antigenic relatedness of F and G gly- Rous sarcoma virus adaptor plasmids genotypic analyses, 2670 coproteins, 3163 DNA insertion simplified, 3004 occurrence, 2670 vaccinia virus recombinant-conferred Retroviruses bluetongue virus serotypes 10 and 17 protection, 3163 interferon action in RD-114 clonal deriv- mixed infection in sheep, 1086 vaccinia virus recombinant vaccine atives rotaviruses from immunodeficient host immune and histopathological different antiviral and gene-inducing heterogeneity of genome rearrange- responses, 3855 responses, 2727 ments, 3365 vaccinia viruses carrying the N gene Moloney murine leukemia virus vectors Recombinant interleukin-2 transcription and translation products, embryonal carcinoma cell gene ex- herpes simplex virus type 2 infection in 2885 pression, 2742 guinea pigs vaccine efficacy, 2885 sequence element mediation, 2742 biological activity with drugs, 2120 Reticuloendotheliosis virus tRNAPrO primer-binding site protective immunity regulation, 2120 B-lymphoma induction characterization, 2071 Regulatory genes c-myc activation, 2084 homologous sequences, 2071 Autographa californica nuclear poly- mutated chicken syncytial virus pro- synthetic oligonucleotide probes, 2071 hedrosis virus virus, 2084 Retroviruses, avian expression, 2091 recombinant murine leukemia virus vec- pol protein processing VOL. 61, 1987 SUBJECT INDEX xxvii

identification of new pol domain, 534 poliovirus snapback double-stranded isolation from immunodeficient host, Retroviruses, murine RNA 3365 horizontal transmission, 1037 analysis, 2307 human rotavirus VP3 protein murine leukemia virus transcriptional poly(A) deficiency, 2307 antigenic variant analysis, 1726 control region RNA synthesis cross-reactive neutralization epitopes, glucocorticoid regulation, 269 adenovirus type 2 IV. promoter dele- 1726 viral enhancer region, 269 tion mutants monoclonal antibody analysis, 1726 Reverse transcriptase interaction, 646 major capsid antigen VP6 avian sarcoma and leukosis viruses transcription factor identification, 646 baculovirus expression system, 1488 pol protein processing, 534 hepatitis B virus replicative intermediate synthesis and immunogenicity, 1488 Ribavirin retroviral vector, 2921 mice with severe combined immunodefi- foot-and-mouth disease virus infection in transfected murine fibroblasts, 2921 ciency vitro influenza virus gene expression animal model, 3345 curing of persistent infection, 233 control mechanisms, early and late, persistent infection, 3345 Ribonucleoprotein complexes 764 plus- and minus-strand RNAs adenovirus type 5-infected HeLa cells nuclear-cytoplasmic transport, 764 synthesis in infected cells, 3479 mRNA and hnRNA association, 3276 poliovirus replication Rous sarcoma virus measles virus RNA 3-methylquercetin selective inhibition, antisense RNA clones synthesized product characterization, 3319 replication inhibition, 921 3381 poliovirus RNA polymerase cis-acting elements in Prague A strain transcription system, 3381 host factor-induced template modifica- gag gene role in transformation, 3401 Ribonucleotide reductase activity tion, 802 localization, 3401 pseudorabies virus poliovirus type 1 crude replication com- env and src gene mRNA biochemical properties, 2046 plexes splicing efficiency, 177 RNA expression in vitro analysis, 2816 env gene expression Epstein-Barr virus gene expression molecular genetic approach, 2816 simian virus 40 P3HR1 superinfection system, 3120 rotaviruses late-region-replacement vector, RNA packaging plus- and minus-strand transcription 1276 ground squirrel hepatitis virus polyribo- and replication, 3479 upstream initiation codon effects, 1276 somes and core particles vesicular stomatitis virus leader RNAs envelope glycoproteins gp85 and gp37 influence of 5'-terminal sequences, 35 and mRNAs intracellular transport and assembly RNA polymerase ATP concentration effect, 3470 analysis, 2981 bacteriophage XplO genome RNA terminal sequences transmembrane and cytoplasmic do- rifampin-resistant transcription, 1695 vesiculoviruses main roles, 2981 modification of 110 subspecies genome conservation and diversity, glycoproteins gp85 and gp37 poliovirus infection, 1002 200 cleavage site mutations, 1609 poliovirus RNA transcription processing blocked, 1609 characterization of product RNAs, 611 Autographa californica nuclear poly- helper-independent retroviral vectors chromatography on hydroxylapatite or hedrosis virus protein genes adaptor plasmid development, 3004 poly(U) Sepharose, 611 divergent transcription, 2264 DNA insertion simplified, 3004 vaccinia virus DNA-dependent subunits HindIII-K significance, 2264 morphf mutants analysis, 1765 bovine leukemia virus trans-acting factor nucleotide sequence analysis, 1893 localization, 1765 cis-acting response element interac- v-src lesion localized, 1893 vaccinia virus temperature-sensitive mu- tion, 2462 mutant dIPA105 tants hepatitis B virus core, X, and S antigens cell-type-specific response, 2530 characterization, 1842 expression, 1108 characterization and sequence, 2523 DNA-dependent subunit, 1842 RNA transcripts p45v-src protein isolation, 2523 RNA polymerase activity hepatitis A virus cDNA tumorigenic properties, 2530 West Nile virus nonstructural protein infectivity in cell culture, 3035 p60V-Src domains NS5 human papillomavirus type 1 plantar membrane-binding domain, 1678 dissociation in vitro, 3641 wart isolates mitogenic activity, 1678 role in synthesis, 3641 identification and mapping, 1913 myristylation, 1678 RNA polymerase-binding proteins R-loop characterization, 1913 p60v-src temperature-sensitive mutants bacteriophage T4 RNA translation effects, 354 gene identification, 597 encephalomyocarditis virus packaging mutant TK15 virus-nonprodu- identification of two new genes, 366 cDNA hybridization effects, 2033 cing variants RNA polymerase-binding sites poliovirus proteinase 2A analysis, 3209 bacteriophage S13 replicative form I eucaryotic initiation factor 4F poly- frequent segregation, 3209 DNA peptide p220 cleavage, 2711 pp60v-src, pp70v-fgr, and pp9Ov-Yes tyrosine localization, 2297 RNA3 amplification kinase activity restriction enzyme cleavage site pro- brome mosaic virus intercistronic and monoclonal antibody inhibition, 1927 tection, 2297 terminal sequences pp6Ov-src transforming protein variants RNA pregenome deletion analysis, 1457 forms, 1593 hepatitis B virus replication strategy RNA-dependent RNA polymerase transcriptional control elements 5'-end determination, 904 poliovirus replicase characterization, 1171 RNA replicase primer-dependent synthesis, 2997 expression, 1171 conserved segment of coliphage QB 1- RNase H activity Ruminant lentiviruses subunit protein Moloney murine leukemia virus plus- replication and cytopathic effects function, 3946 strand primers pathogenicity correlation in vivo, 4038 interference with viral infection, 3946 heterogeneity in vitro, 2843 RNA replication role in formation, 2843 mouse hepatitis virus A59 Rotaviruses S protein replication in vitro, 1814 heterogeneity of genome rearrangements duck hepatitis B virus envelope proteins xxviii SUBJECT INDEX J. VIROL.

biochemical and immunological char- position and orientation effects, 2973 gp7O expression, 928 acterization, 2280 replication role, 2973 T-antigen-positive transformation rever- comparison with preS protein, 2280 core origin of replication tant cell lines SAl rotavirus T-antigen-binding domain, 2143 polyomavirus and adenovirus type 2 plus- and minus-strand RNAs cytoplasmic-localization mutant pSVCT3 retransformation, 1821 synthesis in infected cells, 3479 nuclear large T antigen transforma- retransformation resistance, 1821 VP7 glycoprotein gene tion, 3521 Sinbis virus expression in vaccinia virus, 1054 enhancer elements cDNA clones serotype-specific neutralizing antibod- revertant duplications, 3536 lethal mutation mapping, 3809 ies, 1054 Ha-ras cotransfection RNA transcript production, 3809 Scrapie prions transformation cooperation, 2648 Single-stranded DNA inactivation by UV irradiation herpes simplex virus type 1 infection pseudorabies virus immediate-early pro- resistance to, 159 DNA synthesis amplification, 1427 tein Scrapie-associated fibrils insoluble nuclear superstructures binding, 1855 protease-resistant proteins association early in infection, 748 Small T antigen antibody response in mice, 3688 intron-containing genes polyomavirus transformation immunodecoration, 42 expression by baculovirus vector, cooperation with middle T antigen, Semliki Forest virus 1761 2253 structural polyprotein large T antigen simian virus 40 cellular proteins processing, 1301 cellular chromatin and nuclear matrix complex formation in productively role of capsid protease, 1301 association, 3561 infected cells, 1240 Sendai virus characterization of trans-dominant de- simian virus 40 deletion mutations immunoglobulin A monoclonal antibod- fective mutants, 436 tumor specificity alteration, 1282 ies origin-specific DNA-binding domain simian virus 40 intron-containing genes protection effect, 2624 studies, 3326 expression by baculovirus vector, mucociliary transport polymorphism subnuclear distribution analysis, 3561 1761 linkage to resistance/susceptibility to synthesis and processing, 3950 S-mRNA synthesis lethal infection, 1670 large T antigen and tumor formation La Crosse virus transfection of C gene cDNA relationship in transgenic mice, 2029 translational requirement model, 3960 induction of interferon, 625 large T antigen dephosphorylation La Crosse virus translation requirement Sequence requirements ATPase and DNA-binding effect, 3373 in vitro studies, 87 herpes simplex virus immediate-early DNA replication stimulation, 3373 in vivo studies, 96 gene large T antigen origin binding S-mRNA transcripts regulation by trans-acting factors, 190 ATP role, 3649 La Crosse virus Shope fibroma virus large T-antigen subclasses nucleocapsid assembly sites, 667 core target DNA sequence DNA-binding activity, 2076 Spleen focus-forming virus replicated poxvirus telomeres oligomerization, 2076 envelope glycoproteins with altered resolved, 1957 late promoter sequences membrane domains vaccinia virus symmetry, 1957 characterization, 167 intracellular transport, 4007 Sialylated glycoproteins monoclonal antibody probes leukemogenicity, 4007 reovirus type 3 attachment protein large T-antigen function, 411 Spleen focus-forming virus strain SFFVp binding inhibition, 1407 nonkaryophilic large T antigen erythropoietin response sequences Sigma 1 protein trans-activation of cellular and viral localization, 1661 reovirus serotype 3 (Dearing) promoters, 1296 Spleen lymphoid cells composition, 1834 small t antigen deletion mutations woodchuck hepatitis virus-infected multimeric form identified, 1834 tumor specificity alteration, 1282 woodchucks Sigma 3 protein small t-antigen complex replication site, 1318 reovirus-infected L cells interactions in productively infected Spleen necrosis virus mRNA translation, 2472 cells, 1240 mouse cell model Simian acquired immune deficiency syn- T-antigen binding transcriptional replication block, 3454 drome cytosine residue methylation, 2344 src and env genes type D retrovirus clone interaction, 2344 Rous sarcoma virus disease induction, 3066 T-antigen expression splicing efficiency, 177 DNA sequence, 3066 analysis, 851 src protein localization Simian immunodeficiency virus mouse cell nonpermissivity, 851 detergent-insoluble cellular matrix affin- major histocompatibility complex class T-antigen mutants ities 1I structures DNA replication in human cells, 2864 intracellular differences, 2420 expression in vitro, 1421 spontaneously occurring mutants, 2864 Structural protein VP1 Simian virus 5 transforming nonkaryophilic T antigen polyomavirus fusion and hemagglutinin-neuraminidase oligomeric forms, 940 host cell influence, 509 glycoproteins p53 complex formation, 940 Structural proteins protective immunity roles, 1972 VP1 missense mutations dengue virus proteins vaccinia virus recombinants, 1972 agnogene defect suppression, 3190 expression by recombinant vaccinia Simian virus 40 effect on VP1 self-polymerization, virus, 4019 agnoprotein production 3190 Subacute sclerosing panencephalitis late mRNA translation effect, 2331 LP1 interaction, 3190 measles virus infection agnoprotein role VP2 and VP3 polypeptides interferon role, 1919 replication and maturation pathway intranuclear localization, 3862 Subviral particles regulation, 937 Simian virus 40 transformants poliovirus 55S particles A+T-rich sequence normal cell proliferation blocked assembly sequence, 561 COS cell growth, 2322 cyclic AMP effect, 1546 role in morphogenesis, 561 DNA replication function, 2322 Simian virus 40-transformed cells Superhelical DNAs core origin and transcriptional enhancer macrophage-resistant cells Campoletis sonorensis virus genome VOL. 61, 1987 SUBJECT INDEX xxix

physical analysis, 2589 vaccinia virus gene JC virus mutants repeat element identification, 2589 DNA replication required region, 1398 permissivity increased, 755 Superinfection nucleotide sequence and organization, trans-Inducing protein human immunodeficiency viruses LAV-1 1398 herpes simplex virus type 1 proteins and ARV-1 vaccinia virus RNA polymerase subunit characterization, 2428 induction in a chimpanzee, 4026 characterization, 1842 Transmissible mink encephalopathy virus Surface antigen vesicular stomatitis virus infectious process in mink duck hepatitis B virus pre-S polypeptide phenotypic revertants, 256 extraneural replication, 3235 characterization, 1384 sequence analysis and functional char- temporal distribution, 3235 hepatitis B virus pre-S and precore se- acterization, 256 tRNAPrO primer-binding site quences vesicular stomatitis virus M protein retrovirus-related sequence expression, 683 assembly defective, 1332 characterization, 2071 influences, 683 Terminal inverted repeats homologous sequences, 2071 hepatitis B virus preSl protein bacteriophage PRD1 synthetic oligonucleotide probes, 2071 regulation of secretion, 782 sequence and activity, 594 Tumor formation hepatitis B virus subtypes adr, ayr, and Theiler's murine encephalomyelitis virus simian virus 40 large T antigen adyr anti-A-IS monoclonal antibody relationship in transgenic mice, 2029 characterization, 3030 timing importance of treatment, 898 Tumorigenicity point mutation in S gene, 3030 treatment effect, 898 bovine papillomavirus type 1-infected Surface antigen genes classification with cardioviruses hamster cells hepatitis B virus nucleotide sequence analysis, 1507 RNA levels and protein expression, expression in Saccharomyces cerevi- Thymidine kinase activity 2924 siae, 3543 herpes simplex virus mutants Type D retrovirus clone Surface receptors complementation in vivo, 2171 simian acquired immune deficiency syn- human immunodeficiency virus T cells trigeminal ganglion infection, 2171 drome downregulation, 3741 Thymidine kinase gene disease induction, 3066 noncytopathic infection, 3741 bovine herpesvirus type 1 DNA sequence, 3066 map location, 4023 Type I collagen T-antigen binding Tissue specificity retroviral-vector-mediated transfer of simian virus 40 binding to origin region murine retroviral long terminal repeats proal(I) gene DNA transcriptional activity, 1067 Mov-13 mouse strain model, 2549 cytosine residue methylation, 2344 Tobacco etch virus phenotype rescue, 2549 interaction, 2344 polyprotein gene Tyrosine kinase activity T-antigen expression characterization and mapping, 2540 v-src, v-fgr, and v-yes gene products simian virus 40 proteolytic processing, 2540 monoclonal antibody inhibition, 1927 mouse cell nonpermissivity, 851 Topoisomerase inhibitors pp60v-src binding, 1927 T-antigen-positive cells herpes simplex virus type 1-infected Tyrosine-specific protein kinases simian virus 40-transformed revertants mouse cells pp60c-src and pp60vsrc polyomavirus and adenovirus type 2 reactivation inhibition by novobiocin affinity for detergent-insoluble cellular retransformation, 1821 and coumermycin Al, 3288 matrix, 2420 retransformation resistance, 1821 trans-Activating function T-cell immunity hepatitis B virus U3 region sequences murine cytomegalovirus expression, 3448 Friend and Moloney murine leukemia adoptive spleen cell transfer, 23 localization in X region, 3448 viruses replication in adrenal gland, 23 trans-Activation-responsive element disease specificity determinants, 693 T-cell response parvovirus H-1 P38 promoter Uracil-DNA glycosylase human immunodeficiency virus recombi- characterization, 2807 herpes simplex virus cDNA nant antigens Transcription termination signals activity origin, 3040 infected chimpanzees, 3804 adenovirus type 2 DNA sequences isolation, 3040 Temperature-sensitive mutants cat mRNA inhibition, 2770 UV irradiation adenovirus type 7 localization downstream, 2770 scrapie prions isolation and characterization, 3089 Transcriptional control elements resistance to inactivation, 159 herpes simplex virus type 1 Rous sarcoma virus complementation by varicella-zoster characterization, 1171 v-abl involvement virus, 225 expression, 1171 Moloney murine leukemia virus-induced physical mapping of host shutoff loci, Transcriptional control region myeloid tumors 143 BK virus MM strain variants c-myb activation requirement, 3721 myeloproliferative sarcoma virus clones structure and function, 1747 Vaccinia virus activity, 889 Transformation 14-kilodalton fusion protein mos oncogene point mutation, 889 adenovirus type 5 E2B mutations mapping and nucleotide sequence, poliovirus type 1 recombinants DNA polymerase role, 3630 3550 crossing-over sites on viral genome, human papillomavirus type 16 39,000-Mr immunodominant protein 1722 human fibroblasts and keratinocytes, structure and function, 3910 pseudorabies virus immediate-early gene 1061 attenuation and structural protein modi- adenovirus type 5 ElA coinfection, human papillomavirus type 18 E6 and fications 1103 E7 ORFs persistent infection effects, 2642 transcription of class II and class III transforming function localization, cell fusion genes, 1103 3635 formation of covalently linked trimers, pseudorabies virus immediate-early pro- Transformation-defective mutant 395 tein polyomavirus middle T antigen role of 14,000-Mr envelope protein, role in early gene transcription, 1258 association with 73-kilodalton heat 395 Rous sarcoma virus p6v-sr" mutants shock protein, 405 DNA-dependent RNA polymerase subu- effects, 354 Transformed human fetal glial cells nits xxx SUBJECT INDEX J. VIROL.

analysis, 1765 infectivity model, 2951 Moloney murine sarcoma virus P55 pro- localization, 1765 v-erbB/src fusion polypeptide tein temperature-sensitive mutant charac- chimeric oncogene biological and biochemical analysis, terization, 1842 analysis, 1938 3625 gene required for DNA replication Vesicular stomatitis virus identification, 3625 nucleotide sequence and organization, antibody response by ELISA v-mos expression, 3625 1398 asymmetrically cross-reactive antibod- Visna virus high-frequency homologous DNA re- ies, 2509 complex transcriptional pattern combination immunodominance of serotype-specific significance, 1325 mechanisms, 1788 determinants, 2509 envelope glycoprotein gpl35 late gene cluster coevolution of virus and defective inter- topographical rearrangements during expression and regulation, 639 fering particles antigenic drift, 1019 nucleoside triphosphate phosphohydro- complete resistance to DI particles, lentivirus envelope proteins lase I gene 454 hypervariable site in env gene, 4046 identification, 1738 cytotoxic T-lymphocyte recognition of sequence homology, 4046 recombinants expressing respiratory nucleoprotein antigen v-mil sequences syncytial virus proteins bm3 mutant effect, 1992 MH2 virus immune and histopathological interferon action in RD-114 clonal deriv- propagation in vivo or in vitro, 1949 responses, 3855 atives v-mos expression regulatory region of late promoter different antiviral and gene-inducing Moloney murine sarcoma virus proteins DNA replication, 75 responses, 2727 biological and biochemical analysis, temperature-sensitive mutant interferon treatment 3625 molecular genetic analysis, 3152 expression in RD-114 cells, 1524 P55 and vimentin identification, 3625 role in DNA replication, 3152 replication inhibition, 653 VP1 capsid protein Vaccinia virus recombinants interferon treatment effects poliovirus type 1 carrying respiratory syncytial virus N coinfection with adenovirus, 787 neutralizing antibody induction, 1442 gene modulation by early region 1A, 787 production in Escherichia coli, 1442 construction and characterization, leader RNA and mRNA synthesis polyomavirus 2885 ATP concentration effect, 3470 calcium localization, 2934 transcription and translation products, leader RNA synthesis VP1 missense mutations 2885 cytopathogenicity in Drosophila cells, simian virus 40 vaccine efficacy, 2885 1391 agnogene defect suppression, 3190 Vaccinia virus vectors M protein mutants effect on self-polymerization, 3190 hepatitis B virus middle surface protein assembly defective, 1332 LP1 interaction, 3190 expression of pre-S and S epitopes, permissive macrophages in mice VP7 glycoprotein gene 1286 interferon, reduced levels, 812 SAl1 rotavirus herpes simplex virus type 1 glycoprotein mechanism for natural resistance, 812 expression in vaccinia virus recombi- D recombinant polymerase protein L nants, 1054 cytotoxic T-cell response, 726 homotypic and heterotypic exclusion, serotype-specific neutralizing antibod- human parainfluenza virus type 3 F and 3133 ies, 1054 HN glycoproteins serotypes Indiana and New Jersey contribution to host immunity, 3416 molecular epizootiology and evolution, West Nile virus expression, 3416 1029 nonstructural protein NS5 polyomavirus virion proteins temperature-sensitive M protein mutants RNA synthesis role, 3641 kinetics of association of VP1, VP2, phenotypic revertants, 256 separation from polymerase activity, and VP3, 516 sequence analysis and functional char- 3641 subcellular distribution of proteins, acterization, 256 Woodchuck hepatitis virus 516 Vesiculoviruses ground squirrel hepatitis recombinants pseudorabies virus glycoprotein gp5O genome RNA terminus conservation and infectivity, 3241 subunit vaccine evaluation, 3977 diversity synthesis of novel viruses, 3241 respiratory synctytial virus F protein sequence analysis, 200 lymphoid cells in infected woodchuck expression v-fos oncogene spleens protection of vaccinated mice, 293 avian transforming virus NK24 replication site, 1318 Varicella-zoster virus characterization, 3733 complementation of herpes simplex virus vhsl mutant Xanthomonas campestris pv. oryzae type 1 ts mutants, 225 herpes simplex virus type 1 bacteriophage XplO genome cytotoxic T-cell response stability of immediate-early alpha rifampin-resistant transcription, 1695 detection and frequency analysis, 3463 mRNAs, 604 Xenotropic murine leukemia virus glycoprotein gpII(140) Vimentin mink cell focus-forming virus and pro- assembly and processing, 2877 adenovirus infection viral genes 0-linked glycans, 2877 cleavage and processing, 2559 env gene probes, 3082 infection in marmosets early occurrence, 2559 wild mouse origins, 3082 US. Posfl Servlce STATEMENT OF OWNERSHIP, MANAGEMENT AND CIRCULATION Required by 39 U.S.C. 368S) 1A TITLE OF PUBLICATION 1B. PUBLICATION NO. 2. DATE OF FILING Journal of Virology 0 lo 12 12 15 13 18 X 09/23/87 3. FREQUENCY OF ISSUE 3A. NO. OF ISSUES PUBLISHED 3B. ANNUAL SUBSCRIPTION ANNUALLY P $41 Monthly 12 Nnnmemer,4351 4. COMPLETE MAILING ADDRESS OF KNOWN OFFICE OF PUBLICATION (Strcet. Cirv, County, State and ZIP+4 Code) (Not printers) American Society for Microbiology, 1913 I Street, N.!!., lIashington, DC 20006 S. COMPLETE MAILING ADDRESS OF THE HEADQUARTERS OF GENERAL BUSINESS OFFICES OF THE PUBLISHER (Notprinter) Anerican Society for Microbiology, 1913 I Street, N.W., !lashington, DC 20006 B. FULL NAMES AND COMPLETE MAILING ADDRESS OF PUBLISHER, EDITOR. AND MANAGING EDITOR (7his item MUSTNOTbe blank) PUBLISHER (Name and Complete Mading Address) American Society for Microbiology, 1913 I Street, N.H., lIashington, DC 20006 EDITOR (Name and Complete Mading 4ddress) Arnold J. 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