RC-Specific Evaluation of Cardiomed – Cardiovascular Medicine Seppo Saari & Antti Moilanen (Eds.)

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI 2005–2010 RC-Specific Evaluation of CardioMed – Cardiovascular Medicine Seppo Saari & Antti Moilanen (Eds.)

Evaluation Panel: Medicine, Biomedicine and Health Sciences

University of Helsinki Administrative Publications 80/37 Evaluations 2012

Publisher: University of Helsinki Editors: Seppo Saari & Antti Moilanen

Title: Type of publication: International Evaluation of Research and Doctoral Training at the University of Evaluations Helsinki 2005–2010 : RC-Specific Evaluation of CardioMed – Cardiovascular Medicine

Summary: Researcher Community (RC) was a new concept of the participating unit in the evaluation. Participation in the evaluation was voluntary and the RCs had to choose one of the five characteristic categories to participate. Evaluation of the Researcher Community was based on the answers to the evaluation questions. In addition a list of publications and other activities were provided by the TUHAT system. The CWTS/Leiden University conducted analyses for 80 RCs and the Helsinki University Library for 66 RCs. Panellists, 49 and two special experts in five panels evaluated all the evaluation material as a whole and discussed the feedback for RC-specific reports in the panel meetings in Helsinki. The main part of this report is consisted of the feedback which is published as such in the report. Chapters in the report: 1. Background for the evaluation 2. Evaluation feedback for the Researcher Community 3. List of publications 4. List of activities 5. Bibliometric analyses The level of the RCs’ success can be concluded from the written feedback together with the numeric evaluation of four evaluation questions and the category fitness. More conclusions of the success can be drawn based on the University-level report. RC-specific information: Main scientific field of research: RC-specific keywords: Medicine, Biomedicine and Health Sciences Cardiovascular pharmacology; Regenerative medicine, Cell therapy, Personalized medicine; Pharmacogenetics; Participation category: Drug development; Nutrition; Functional foods; 2. Research of the participating community is Metabolism; Translational Research; Inflammation of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break- through

RC’s responsible person: Mervaala, Eero

Keywords: Research Evaluation, Meta-evaluation, Doctoral Training, Bibliometric Analyses, Researcher Community

Series title and number: University of Helsinki, Administrative Publications 80/37, Evaluations ISSN: ISBN: 1795-5513 (Online) 978-952-10-7457-8 (PDF)

Total number of pages: Language: 69 English Additional information: Internet address: Cover graphics: Päivi Talonpoika-Ukkonen http://www.helsinki.fi/julkaisut/aineisto/rc_evaluation Enquiries: [email protected] 2012/hallinnon_julkaisuja_80_37_2012.pdf

Contents Panel members ...... 1 1 Introduction to the Evaluation ...... 5 1.1 RC-specific evaluation reports ...... 5 1.2 Aims and objectives in the evaluation ...... 5 1.3 Evaluation method ...... 5 1.4 Implementation of the external evaluation ...... 6 1.5 Evaluation material ...... 7 1.6 Evaluation questions and material ...... 8 1.7 Evaluation criteria ...... 10 1.8 Timetable of the evaluation ...... 13 1.9 Evaluation feedback – consensus of the entire panel ...... 13 2 Evaluation feedback ...... 15 2.1 Focus and quality of the RC’s research ...... 15 2.2 Practises and quality of doctoral training ...... 15 2.3 The societal impact of research and doctoral training ...... 16 2.4 International and national (incl. intersectoral) research collaboration and researcher mobility ...... 16 2.5 Operational conditions ...... 17 2.6 Leadership and management in the researcher community ...... 17 2.7 External competitive funding of the RC ...... 17 2.8 The RC’s strategic action plan for 2011–2013 ...... 18 2.9 Evaluation of the category of the RC in the context of entity of the evaluation material (1-8) ...... 18 2.10 Short description of how the RC members contributed the compilation of the stage 2 material ... 18 2.11 How the UH’s focus areas are presented in the RC’s research ...... 18 2.12 RC-specific main recommendations ...... 18 2.13 RC-specific conclusions ...... 19 3 Appendices ...... 21

Foreword

The evaluation of research and doctoral training is being carried out in the years 2010–2012 and will end in 2012. The steering group appointed by the Rector in January 2010 set the conditions for participating in the evaluation and prepared the Terms of Reference to present the evaluation procedure and criteria. The publications and other scientific activities included in the evaluation covered the years 2005–2010. The participating unit in the evaluation was defined as a Researcher Community (RC). To obtain a critical mass with university-level impact, the number of members was set to range from 20 to 120. The RCs were required to contain researchers in all stages of their research career, from doctoral students to principal investigators (PIs). All in all, 136 Researcher Communities participated in this voluntary evaluation, 5857 persons in total, of whom 1131 were principal investigators. PIs were allowed to participate in two communities in certain cases, and 72 of them used this opportunity and participated in two RCs. This evaluation enabled researchers to define RCs from the “bottom up” and across disciplines. The aim of the evaluation was not to assess individual performance but a community with shared aims and researcher-training activities. The RCs were able to choose among five different categories that characterised the status and main aims of their research. The steering group considered the process of applying to participate in the evaluation to be important, which lead to the establishment of these categories. In addition, providing a service for the RCs to enable them to benchmark their research at the global level was a main goal of the evaluation. The data for the evaluation consisted of the RCs’ answers to evaluation questions on supplied e-forms and a compilation extracted from the TUHAT – Research Information System (RIS) on 12 April 2011. The compilation covered scientific and other publications as well as certain areas of scientific activities. During the process, the RCs were asked to check the list of publications and other scientific activities and make corrections if needed. These TUHAT compilations are public and available on the evaluation project sites of each RC in the TUHAT-RIS. In addition to the e-form and TUHAT compilation, University of Leiden (CWTS) carried out bibliometric analyses from the articles included in the Web of Science (WoS). This was done on University and RC levels. In cases where the publication forums of the RC were clearly not represented by the WoS data, the Library of the University of Helsinki conducted a separate analysis of the publications. This was done for 66 RCs representing the humanities and social sciences. The evaluation office also carried out an enquiry targeted to the supervisors and PhD candidates about the organisation of doctoral studies at the University of Helsinki. This and other documents describing the University and the Finnish higher education system were provided to the panellists. The panel feedback for each RC is unique and presented as an entity. The first collective evaluation reports available for the whole panel were prepared in July–August 2011. The reports were accessible to all panel members via the electronic evaluation platform in August. Scoring from 1 to 5 was used to complement written feedback in association with evaluation questions 1–4 (scientific focus and quality, doctoral training, societal impact, cooperation) and in addition to the category evaluating the fitness for participation in the evaluation. Panellists used the international level as a point of comparison in the evaluation. Scoring was not expected to go along with a preset deviation. Each of the draft reports were discussed and dealt with by the panel in meetings in Helsinki (from 11 September to 13 September or from 18 September to 20 September 2011). In these meetings the panels also examined the deviations among the scores and finalised the draft reports together. The current RC-specific report deals shortly with the background of the evaluation and the terms of participation. The main evaluation feedback is provided in the evaluation report, organised according to the evaluation questions. The original material provided by the RCs for the panellists has been attached to these documents.

On behalf of the evaluation steering group and office, I sincerely wish to thank you warmly for your participation in this evaluation. The effort you made in submitting the data to TUHAT-RIS is gratefully acknowledged by the University. We wish that you find this panel feedback useful in many ways. The bibliometric profiles may open a new view on your publication forums and provide a perspective for discussion on your choice of forums. We especially hope that this evaluation report will help you in setting the future goals of your research.

Johanna Björkroth Vice-Rector Chair of the Steering Group of the Evaluation

Steering Group of the evaluation Steering group, nominated by the Rector of the University, was responsible for the planning of the evaluation and its implementation having altogether 22 meetings between February 2010 and March 2012.

Chair Vice-Rector, professor Johanna Björkroth

Vice-Chair Professor Marja Airaksinen

Chief Information Specialist, Dr Maria Forsman Professor Arto Mustajoki University Lecturer, Dr Kirsi Pyhältö Director of Strategic Planning and Development, Dr Ossi Tuomi Doctoral candidate, MSocSc Jussi Vauhkonen

Panel members

CHAIR Professor Lorenz Poellinger Cancer biology, cell and molecular biology Karolinska Institute, Sweden

VICE-CHAIR Professor Cornelia van Duijn Genetic epidemiology, Alzheimer’s disease and related disorders Erasmus Medical Centre, the Netherlands

Professor Johanna Ivaska Molecular cell biology, cell adhesion, cancer biology University of Turku, VTT Technical Research Centre, Finland

Professor Olli Lassila Immunology, medical microbiology University of Turku, Finland

Professor Hans-Christian Pape Neuroscience, neurophysiology University of Münster, Germany

Professor Thomas Ruzicka Dermatology, allergology Ludwig-Maximilians-Universität (LMU) München, Germany

Professor Lars Terenius Experimental alcohol and drug dependence research, mental disorders, preventive medicine Karolinska Institute, Sweden

Professor Peter York Physical pharmaceutics, pharmaceutical chemistry, pharmaceutical technology University of Bradford, Great Britain

The panel, independently, evaluated all the submitted material and was responsible for the feedback of the RC-specific reports. The panel members were asked to confirm whether they had any conflict of interests with the RCs. If this was the case, the panel members disqualified themselves in discussion and report writing.

Added expertise to the evaluation was contributed by two evaluators outside the panels and by three members from the other panels.

External Experts Professor Olli Carpén Pathology, cancer cell metastasis University of Turku Finland

Professor Anders Linde Oral biochemi Faculty of Odontology Göteborg University Sweden

Experts from the Other Panels Professor Jan-Otto Carlsson, from the Panel of Natural Sciences Professor Danny Huylebroek, from the Panel of Biological, Agricultural and Veterinary Sciences Professor Holger Stark, from the Panel of Natural Sciences

EVALUATION OFFICE Dr Seppo Saari, Doc., Senior Adviser in Evaluation, was responsible for the entire evaluation, its planning and implementation and acted as an Editor-in-chief of the reports. Dr Eeva Sievi, Doc., Adviser, was responsible for the registration and evaluation material compilations for the panellists. She worked in the evaluation office from August 2010 to July 2011. MSocSc Paula Ranne, Planning Officer, was responsible for organising the panel meetings and all the other practical issues like agreements and fees and editing a part the RC-specific reports. She worked in the evaluation office from March 2011 to January 2012. Mr Antti Moilanen, Project Secretary, was responsible for editing the reports. He worked in the evaluation office from January 2012 to April 2012.

TUHAT OFFICE Provision of the publication and other scientific activity data Mrs Aija Kaitera, Project Manager of TUHAT-RIS served the project ex officio providing the evaluation project with the updated information from TUHAT-RIS. The TUHAT office assisted in mapping the publications with CWTS/University of Leiden. MA Liisa Ekebom, Assisting Officer, served in TUHAT-RIS updating the publications for the evaluation. She also assisted the UH/Library analyses. BA Liisa Jäppinen, Assisting Officer, served in TUHAT-RIS updating the publications for the evaluation.

HELSINKI UNIVERSITY LIBRARY Provision of the publication analyses Dr Maria Forsman, Chief Information Specialist in the Helsinki University Library, managed with her 10 colleagues the bibliometric analyses in humanities, social sciences and in other fields of sciences where CWTS analyses were not applicable.

Acronyms and abbreviations applied in the report

External competitive funding AF – Academy of Finland TEKES - Finnish Funding Agency for Technology and Innovation EU - European Union ERC - European Research Council International and national foundations FP7/6 etc. /Framework Programmes/Funding of European Commission

Evaluation marks Outstanding (5) Excellent (4) Very Good (3) Good (2) Sufficient (1)

Abbreviations of Bibliometric Indicators P - Number of publications TCS – Total number of citations MCS - Number of citations per publication, excluding self-citations PNC - Percentage of uncited publications MNCS - Field-normalized number of citations per publication MNJS - Field-normalized average journal impact THCP10 - Field-normalized proportion highly cited publications (top 10%) INT_COV - Internal coverage, the average amount of references covered by the WoS WoS – Thomson Reuters Web of Science Databases

Participation category Category 1. The research of the participating community represents the international cutting edge in its field. Category 2. The research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break-through. Category 3. The research of the participating community is distinct from mainstream research, and the special features of the research tradition in the field must be considered in the evaluation. Category 4. The research of the participating community represents an innovative opening. Category 5. The research of the participating community has a highly significant societal impact.

Research focus areas of the University of Helsinki Focus area 1: The basic structure, materials and natural resources of the physical world Focus area 2: The basic structure of life Focus area 3: The changing environment – clean water Focus area 4: The thinking and learning human being Focus area 5: Welfare and safety Focus area 6: Clinical research Focus area 7: Precise reasoning Focus area 8: Language and culture Focus area 9: Social justice Focus area 10: Globalisation and social change

1 Introduction to the Evaluation

1.1 RC-specific evaluation reports

The participants in the evaluation of research and doctoral training were Researcher Communities (hereafter referred to as the RC). The RC refers to the group of researchers who registered together in the evaluation of their research and doctoral training. Preconditions in forming RCs were stated in the Guidelines for the Participating Researcher Communities. The RCs defined themselves whether their compositions should be considered well-established or new. It is essential to emphasise that the evaluation combines both meta-evaluation1 and traditional research assessment exercise and its focus is both on the research outcomes and procedures associated with research and doctoral training. The approach to the evaluation is enhancement-led where self- evaluation constituted the main information. The answers to the evaluation questions formed together with the information of publications and other scientific activities an entity that was to be reviewed as a whole. The present evaluation recognizes and justifies the diversity of research practices and publication traditions. Traditional Research Assessment Exercises do not necessarily value high quality research with low volumes or research distinct from mainstream research. It is challenging to expose the diversity of research to fair comparison. To understand the essence of different research practices and to do justice to their diversity was one of the main challenges of the present evaluation method. Understanding the divergent starting points of the RCs demanded sensitivity from the evaluators.

1.2 Aims and objectives in the evaluation

The aims of the evaluation are as follows:

. to improve the level of research and doctoral training at the University of Helsinki and to raise their international profile in accordance with the University’s strategic policies. The improvement of doctoral training should be compared to the University’s policy.2 . to enhance the research conducted at the University by taking into account the diversity, originality, multidisciplinary nature, success and field-specificity, . to recognize the conditions and prerequisites under which excellent, original and high-impact research is carried out, . to offer the academic community the opportunity to receive topical and versatile international peer feedback, . to better recognize the University’s research potential. . to exploit the University’s TUHAT research information system to enable transparency of publishing activities and in the production of reliable, comparable data.

1.3 Evaluation method

The evaluation can be considered as an enhancement-led evaluation. Instead of ranking, the main aim is to provide useful information for the enhancement of research and doctoral training of the participating RCs. The comparison should take into account each field of science and acknowledge their special character.

1 The panellists did not read research reports or abstracts but instead, they evaluated answers to the evaluation questions, tables and compilations of publications, other scientific activities, bibliometrics or comparable analyses. 2 Policies on doctoral degrees and other postgraduate degrees at the University of Helsinki.

The comparison produced information about the present status and factors that have lead to success. Also challenges in the operations and outcomes were recognized. The evaluation approach has been designed to recognize better the significance and specific nature of researcher communities and research areas in the multidisciplinary top-level university. Furthermore, one of the aims of the evaluation is to bring to light those evaluation aspects that differ from the prevalent ones. Thus the views of various fields of research can be described and research arising from various starting points understood better. The doctoral training is integrated into the evaluation as a natural component related to research. Operational processes of doctoral training are being examined in the evaluation.

Five stages of the evaluation method were: 1. Registration – Stage 1 2. Self-evaluation – Stage 2 3. TUHAT3 compilations on publications and other scientific activities4 4. External evaluation 5. Public reporting

1.4 Implementation of the external evaluation

Five Evaluation Panels Five evaluation panels consisted of independent, renowned and highly respected experts. The main domains of the panels are: 1. biological, agricultural and veterinary sciences 2. medicine, biomedicine and health sciences 3. natural sciences 4. humanities 5. social sciences The University invited 10 renowned scientists to act as chairs or vice-chairs of the five panels based on the suggestions of faculties and independent institutes. Besides leading the work of the panel, an additional role of the chairs was to discuss with other panel chairs in order to adopt a broadly similar approach. The panel chairs and vice-chairs had a pre-meeting on 27 May 2011 in Amsterdam. The panel compositions were nominated by the Rector of the University 27 April 2011. The participating RCs suggested the panel members. The total number of panel members was 50. The reason for a smaller number of panellists as compared to the previous evaluations was the character of the evaluation as a meta-evaluation. The panellists did not read research reports or abstracts but instead, they evaluated answers to the evaluation questions, tables and compilations of publications, other scientific activities, bibliometrics and comparable analyses.

The panel meetings were held in Helsinki: . On 11–13 September 2011: (1) biological, agricultural and veterinary sciences, (2) medicine, biomedicine and health sciences and (3) natural sciences. . On 18–20 September 2011: (4) humanities and (5) social sciences.

3 TUHAT (acronym) of Research Information System (RIS) of the University of Helsinki 4 Supervision of thesis, prizes and awards, editorial work and peer reviews, participation in committees, boards and networks and public appearances.

1.5 Evaluation material

The main material in the evaluation was the RCs’ self-evaluations that were qualitative in character and allowed the RCs to choose what was important to mention or emphasise and what was left unmentioned. The present evaluation is exceptional at least in the Finnish context because it is based on both the evaluation documentation (self-evaluation questions, publications and other scientific activities) and the bibliometric reports. All documents were delivered to the panellists for examination. Traditional bibliometrics can be reasonably done mainly in medicine, biosciences and natural sciences when using the Web of Science database, for example. Bibliometrics, provided by CWTS/The Centre for Science and Technology Studies, University of Leiden, cover only the publications that include WoS identification in the TUHAT-RIS. Traditional bibliometrics are seldom relevant in humanities and social sciences because the international comparable databases do not store every type of high quality research publications, such as books and monographs and scientific journals in other languages than English. The Helsinki University Library has done analysis to the RCs, if their publications were not well represented in the Web of Science databases (RCs should have at least 50 publications and internal coverage of publications more than 40%) – it meant 58 RCs. The bibliometric material for the evaluation panels was available in June 2011. The RC- specific bibliometric reports are attached at the end of each report. The panels were provided with the evaluation material and all other necessary background information, such as the basic information about the University of Helsinki and the Finnish higher education system.

Evaluation material 1. Registration documents of the RCs for the background information 2. Self evaluation material – answers to the evaluation questions 3. Publications and other scientific activities based on the TUHAT RIS: 3.1. statistics of publications 3.2. list of publications 3.3. statistics of other scientific activities 3.4. list of other scientific activities 4. Bibliometrics and comparable analyses: 4.1. Analyses of publications based on the verification of TUHAT-RIS publications with the Web of Science publications (CWTS/University of Leiden) 4.2. Publication statistics analysed by the Helsinki University Library - mainly for humanities and social sciences 5. University level survey on doctoral training (August 2011) 6. University level analysis on publications 2005–2010 (August 2011) provided by CWTS/University of Leiden

Background material

University of Helsinki - Basic information about the University of the Helsinki - The structure of doctoral training at the University of Helsinki - Previous evaluations of research at the University of Helsinki – links to the reports: 1998 and 2005

The Finnish Universities/Research Institutes - Finnish University system - Evaluation of the Finnish National Innovation System - The State and Quality of Scientific Research in Finland. Publication of the Academy of Finland 9/09.

The evaluation panels were provided also with other relevant material on request before the meetings in Helsinki.

1.6 Evaluation questions and material

The participating RCs answered the following evaluation questions which are presented according to the evaluation form. In addition, TUHAT RIS was used to provide the additional material as explained. For giving the feedback to the RCs, the panellists received the evaluation feedback form constructed in line with the evaluation questions:

1. Focus and quality of the RC’s research . Description of the RC’s research focus. the quality of the RC’s research (incl. key research questions and results) the scientific significance of the RC’s research in the research field(s) . Identification of the ways to strengthen the focus and improve the quality of the RC’s research The additional material: TUHAT compilation of the RC’s publications, analysis of the RC’s publications data (provided by University of Leiden and the Helsinki University Library) A written feedback from the aspects of: scientific quality, scientific significance, societal impact, innovativeness . Strengths . Areas of development . Other remarks . Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

2. Practises and quality of doctoral training . Organising of the doctoral training in the RC. Description of the RC’s principles for: recruitment and selection of doctoral candidates supervision of doctoral candidates collaboration with faculties, departments/institutes, and potential graduate schools/doctoral programmes good practises and quality assurance in doctoral training assuring of good career perspectives for the doctoral candidates/fresh doctorates . Identification of the RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development. The additional material: TUHAT compilation of the RC’s other scientific activities/supervision of doctoral dissertations A written feedback from the aspects of: processes and good practices related to leadership and management . Strengths . Areas of development . Other remarks . Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

3. The societal impact of research and doctoral training . Description on how the RC interacts with and contributes to the society (collaboration with public, private and/or 3rd sector). . Identification of the ways to strengthen the societal impact of the RC’s research and doctoral training. The additional material: TUHAT compilation of the RC’s other scientific activities. A written feedback from the aspects of: societal impact, national and international collaboration, innovativeness

. Strengths . Areas of development . Other remarks . Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

4. International and national (incl. intersectoral) research collaboration and researcher mobility . Description of the RC’s research collaborations and joint doctoral training activities how the RC has promoted researcher mobility . Identification of the RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development. A written feedback from the aspects of: scientific quality, national and international collaboration . Strengths . Areas of development . Other remarks . Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

5. Operational conditions . Description of the operational conditions in the RC’s research environment (e.g. research infrastructure, balance between research and teaching duties). . Identification of the RC’s strengths and challenges related to operational conditions, and the actions planned for their development. A written feedback from the aspects of: processes and good practices related to leadership and management . Strengths . Areas of development . Other remarks . Recommendations

6. Leadership and management in the researcher community . Description of the execution and processes of leadership in the RC how the management-related responsibilities and roles are distributed in the RC how the leadership- and management-related processes support - high quality research - collaboration between principal investigators and other researchers in the RC the RC’s research focus - strengthening of the RC’s know-how . Identification of the RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes

7. External competitive funding of the RC . The RCs were asked to provide information of such external competitive funding, where: the funding decisions have been made during 1.1.2005-31.12.2010, and the administrator of the funding is/has been the University of Helsinki . On the e-form the RCs were asked to provide: 1) The relevant funding source(s) from a given list (Academy of Finland/Research Council, TEKES/The Finnish Funding Agency for Technology and Innovation , EU, ERC, foundations, other national funding organisations, other international funding organisations), and 2)The total sum of funding which the organisation in question had decided to allocate to the RCs members during 1.1.2005–31.12.2010.

Competitive funding reported in the text is also to be considered when evaluating this point. A written feedback from the aspects of: scientific quality, scientific significance, societal impact, innovativeness, future significance . Strengths . Areas of development . Other remarks . Recommendations

8. The RC’s strategic action plan for 2011–2013 . RC’s description of their future perspectives in relation to research and doctoral training. A written feedback from the aspects of: scientific quality, scientific significance, societal Impact, processes and good practices related to leadership and management, national and international collaboration, innovativeness, future significance . Strengths . Areas of development

. Other remarks . Recommendations

9. Evaluation of the category of the RC in the context of entity of the evaluation material (1-8)

The RC’s fitness to the chosen participation category A written feedback evaluating the RC’s fitness to the chosen participation category . Strengths . Areas of development . Other remarks . Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

10. Short description of how the RC members contributed the compilation of the stage 2 material Comments on the compilation of evaluation material

11. How the UH’s focus areas are presented in the RC’s research? Comments if applicable

12. RC-specific main recommendations based on the previous questions 1–11

13. RC-specific conclusions

1.7 Evaluation criteria

The panellists were expected to give evaluative and analytical feedback to each evaluation question according to their aspects in order to describe and justify the quality of the submitted material. In addition, the evaluation feedback was asked to be pointed out the level of the performance according to the following classifications: . outstanding (5) . excellent (4) . very good (3) . good (2) . sufficient (1)

Evaluation according to the criteria was to be made with thorough consideration of the entire evaluation material of the RC in question. Finally, in questions 1-4 and 9, the panellists were expected to classify their written feedback into one of the provided levels (the levels included respective descriptions, ‘criteria’). Some panels used decimals in marks. The descriptive level was interpreted according to the integers and not rounding up the decimals by the editors.

Description of criteria levels Question 1 – FOCUS AND QUALITY OF THE RC’S RESEARCH

Classification: Criteria (level of procedures and results) Outstanding quality of procedures and results (5) Outstandingly strong research, also from international perspective. Attracts great international interest with a wide impact, including publications in leading journals and/or monographs published by leading international publishing houses. The research has world leading qualities. The research focus, key research questions scientific significance, societal impact and innovativeness are of outstanding quality. In cases where the research is of a national character and, in the judgement of the evaluators, should remain so, the concepts of ”international attention” or ”international impact” etc. in the grading criteria above may be replaced by ”international comparability”.

Operations and procedures are of outstanding quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are in alignment with the documentation. The ambition to develop the community together is of outstanding quality. Excellent quality of procedures and results (4) Research of excellent quality. Typically published with great impact, also internationally. Without doubt, the research has a leading position in its field in Finland. Operations and procedures are of excellent quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of excellent quality. Very good quality of procedures and results (3) The research is of such very good quality that it attracts wide national and international attention. Operations and procedures are of very good quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of very good quality. Good quality of procedures and results (2) Good research attracting mainly national attention but possessing international potential, extraordinarily high relevance may motivate good research. Operations and procedures are of good quality, shared occasionally in the community. The improvement of research and other efforts are occasionally documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of good quality. Sufficient quality of procedures and results (1) In some cases the research is insufficient and reports do not gain wide circulation or do not have national or international attention. Research activities should be revised. Operations and procedures are of sufficient quality, shared occasionally in the community. The improvement of research and other efforts are occasionally documented and operations and practices are to some extent in alignment with the documentation. The ambition to develop the community together is of sufficient quality.

Question 2 – DOCTORAL TRAINING Question 3 – SOCIETAL IMPACT Question 4 – COLLABORATION

Classification: Criteria (level of procedures and results) Outstanding quality of procedures and results (5) Procedures are of outstanding quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are in alignment with the documentation. The ambition to develop the community together is of outstanding quality. The procedures and results are regularly evaluated and the feedback has an effect on the planning. Excellent quality of procedures and results (4) Procedures are of excellent quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of excellent quality. The procedures and outcomes are evaluated and the feedback has an effect on the planning. Very good quality of procedures and results (3) Procedures are of very good quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and

management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of very good quality. Good quality of procedures and results (2) Procedures are of good quality, shared occasionally in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of good quality. Sufficient quality of procedures and results (1) Procedures are of sufficient quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are occasionally documented and operations and practices are to some extent in alignment with the documentation. The ambition to develop the community together is of sufficient quality.

Question 9 – CATEGORY Participation category – fitness for the category chosen

The choice and justification for the chosen category below should be reflected in the RC’s responses to the evaluation questions 1–8.

1. The research of the participating community represents the international cutting edge in its field. 2. The research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break-through. 3. The research of the participating community is distinct from mainstream research, and the special features of the research tradition in the field must be considered in the evaluation. The research is of high quality and has great significance and impact in its field. However, the generally used research evaluation methods do not necessarily shed sufficient light on the merits of the research. 4. The research of the participating community represents an innovative opening. A new opening can be an innovative combination of research fields, or it can be proven to have a special social, national or international demand or other significance. Even if the researcher community in its present composition has yet to obtain proof of international success, its members can produce convincing evidence of the high level of their previous research. 5. The research of the participating community has a highly significant societal impact. The participating researcher community is able to justify the high social significance of its research. The research may relate to national legislation, media visibility or participation in social debate, or other activities promoting social development and human welfare. In addition to having societal impact, the research must be of a high standard.

An example of outstanding fitness for category choice (5) 5

The RC’s representation and argumentation for the chosen category were convincing. The RC recognized its real capacity and apparent outcomes in a wider context to the research communities. The specific character of the RC was well-recognized and well stated in the responses. The RC fitted optimally for the category.

. Outstanding (5) . Excellent (4) . Very good (3) . Good (2) . Sufficient (1) The above-mentioned definition of outstanding was only an example in order to assist the panellists in the positioning of the classification. There was no exact definition for the category fitness.

5 The panels discussed the category fitness and made the final conclusions of the interpretation of it.

1.8 Timetable of the evaluation

The main timetable of the evaluation: 1. Registration November 2010 2. Submission of self-evaluation materials January–February 2011 3. External peer review May–September 2011 4. Published reports March–April 2012 - University level public report - RC specific reports

The entire evaluation was implemented during the university’s strategy period 2010–2012. The preliminary results were available for the planning of the following strategy period in late autumn 2011. The evaluation reports will be published in March/April 2012. More detailed time schedule is published in the University report.

1.9 Evaluation feedback – consensus of the entire panel

The panellists evaluated all the RC-specific material before the meetings in Helsinki and mailed the draft reports to the evaluation office. The latest interim versions were on-line available to all the panellists on the Wiki-sites. In September 2011, in Helsinki the panels discussed the material, revised the first draft reports and decided the final numeric evaluation. After the meetings in Helsinki, the panels continued working and finalised the reports before the end of November 2011. The final RC-specific reports are the consensus of the entire panel. The evaluation reports were written by the panels independently. During the editing process, the evaluation office requested some clarifications from the panels when necessary. The tone and style in the reports were not harmonized in the editing process. All the reports follow the original texts written by the panels as far as it was possible. The original evaluation material of the RCs, provided for the panellists is attached at the end of the report. It is essential to notice that the exported lists of publications and other scientific activities depend how the data was stored in the TUHAT-RIS by the RCs.

2 Evaluation feedback

2.1 Focus and quality of the RC’s research

. Description of . the RC’s research focus . the quality of the RC’s research (incl. key research questions and results) . the scientific significance of the RC’s research in the research field(s) . Identification of the ways to strengthen the focus and improve the quality of the RC’s research ASPECTS: Scientific quality, scientific significance, societal impact, innovativeness

The RC is divided into four main topics: cardiovascular pharmacology, regenerative therapy, nutrition/functional food and clinical cardiology/hypertension genetics within a relative small RC size, especially when divided into four main topics. This breadth raises concerns over the research focus of the RC. They have produced a high productivity on papers with generally good impact and citation rates as well as some IP with patents, although efforts should be made to increase the impact of publications especially those categorized as food science and technology to enhance international standing of these works. Despite the diversity in topics, they managed in different interdisciplinary and translational approaches, the balance of basic and clinical sciences, as well as their promising merging. New therapeutical approaches with new medical entities in combination with international core programs or international associations resulted in a heterogeneous, but successful RC. The thematic overlap in some of the main topics may require further focus for internal RC cooperation in addition when considering expanding connections to other topics related RCs within UH. Numeric evaluation: 3 (Very good)

2.2 Practises and quality of doctoral training

. Organising of the doctoral training in the RC. Description of the RC’s principles for: . recruitment and selection of doctoral candidates . supervision of doctoral candidates . collaboration with faculties, departments/institutes, and potential graduate schools/doctoral programmes . good practises and quality assurance in doctoral training . assuring of good career perspectives for the doctoral candidates/fresh doctorates . Identification of the RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development. . Additional material: TUHAT compilation of the RC’s other scientific activities/supervision of doctoral dissertations ASPECTS: Processes and good practices related to leadership and management

There is a good training program for the PhD students. The outlook for good positions is good although the general number of free position for excellent academics is limited. The teaching work-load for the PhD students as well as for the supervisors at different levels is not clear, but the impression is given that there is an overload or imbalance of too much teaching and a smaller part for research. Detail of the overall duration of PhD studies should be provided and, as with numerous RCs, it seems to be much longer than the internationally accepted three to four years. The workload for PhD students should be given in more details and more attention given to the important role of the PhD thesis committee.

An alumni register would be helpful to follow the career of the former students. The international exchange can be enlarged by sending the PhD students to foreign labs. Here the installation of European networks and grants would be helpful. With the different institutes there appears to be different PhD student programs. With a general core structure for a number of RCs or institutes, complimented by different specialized course for the detailed programmes of the RC, the work-load may be reduced. It is not clear if it is free to choose from one to three supervisors. A number of two to three seems to be more appropriate. An increase of meetings for PhD committees from a minimum of one per annum would benefit doctoral students and help to direct and improve the mentoring and advisory support by supervisors. The gender problem can be raised in general terms in respect to the higher classification of students and PhD students. It is not restricted to this RC, but a general question. Another general problem is related to the career development after PhD graduation. Numeric evaluation: 3 (Very good)

2.3 The societal impact of research and doctoral training

. Description on how the RC interacts with and contributes to the society (collaboration with public, private and/or 3rd sector). . Identification of the ways to strengthen the societal impact of the RC’s research and doctoral training. . Additional material: TUHAT compilation of the RC’s other scientific activities. ASPECTS: Societal impact, national and international collaboration, innovativeness

The RC members are involved in different national scientific organizations and have taken over leadership responsibilities. As clinical research usually has more direct and therefore, larger impact on society, this may be stressed with further popular contributions to community. It should be stated that the already achieved social and public effects are at a very good level. Numeric evaluation: 3 (Very good)

2.4 International and national (incl. intersectoral) research collaboration and researcher mobility

. Description of . the RC’s research collaborations and joint doctoral training activities . how the RC has promoted researcher mobility . Identification of the RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development. ASPECTS: Scientific quality, national and international collaboration

The RC has carried out very well concerning the international exchange and cooperation with broad contacts all over the world with some clear focus on Europe. The exchange has been productive in both ways. International winter schools are productive in developing positive multinational interactions. Numerous exchange programs are performed with other European countries including on joint doctoral training. Numeric evaluation: 4 (Excellent)

2.5 Operational conditions

. Description of the operational conditions in the RC’s research environment (e.g. research infrastructure, balance between research and teaching duties). . Identification of the RC’s strengths and challenges related to operational conditions, and the actions planned for their development. ASPECTS: Processes and good practices related to leadership and management

Research is performed in a modern laboratory space. Administrative work and teaching duties seem to take a lot of time from research. UH should take care that an appropriate balance can be maintained. The room facilities and the conditions of instruments are unclear from the broad description.

2.6 Leadership and management in the researcher community

. Description of . the execution and processes of leadership in the RC . how the management-related responsibilities and roles are distributed in the RC . how the leadership- and management-related processes support . high quality research . collaboration between principal investigators and other researchers in the RC . the RC’s research focus . strengthening of the RC’s know-how . Identification of the RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes ASPECTS: Processes and good practices related to leadership and management

Different members of the RC have successfully taken leadership roles in different national and international organisations.

2.7 External competitive funding of the RC

• The RCs were asked to provide information of such external competitive funding, where: • the funding decisions have been made during 1.1.2005–31.12.2010, and • the administrator of the funding is/has been the University of Helsinki • On the e-form the RCs were asked to provide: 1) The relevant funding source(s) from a given list (Academy of Finland/Research Council, TEKES/The Finnish Funding Agency for Technology and Innovation, EU, ERC, foundations, other national funding organisations, other international funding organizations), and 2) The total sum of funding which the organisation in question had decided to allocate to the RCs members during 1.1.2005–31.12.2010. Competitive funding reported in the text is also to be considered when evaluating this point. ASPECTS: Scientific quality, scientific significance, societal impact, innovativeness and future significance

The level of external grants for funding research at circa €3.8m is good with funding from the Academy of Finland, TEKES, Finnish Foundation for CV Research, and EVO-funding as well as the pharmaceutical and food industries. With an absence of funding from the EU, the RC is advised to examine ways to secure grants or be involved in collaborative programmes from this source.

2.8 The RC’s strategic action plan for 2011–2013

• RC’s description of their future perspectives in relation to research and doctoral training. ASPECTS: Scientific quality, scientific significance, societal Impact, processes and good practices related to leadership and management, national and international collaboration, innovativeness, future significance

For the near future the current activities of the RC should be further supported in the different interdisciplinary and translational steps in basic and clinical research. The interaction between the main topics and the groups within the RC should be strengthened. As the communication and exchange with national and international scientist is already at a high level the communication of scientific findings to publicity should be operating at the same level. In some cases nutrition and genetics play major roles and the problem/topic of epigenetics may be considered by the RC at an early stage in the future.

2.9 Evaluation of the category of the RC in the context of entity of the evaluation material (1-8)

The RC’s fitness to the chosen participation category. Category 2. The research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break-through.

The RC is one of the national leading research teams with good quality in international research. Within the relative small RC size, they have achieved a very good performance in research and doctoral training, and good visibility. Participation category 2 ‘The research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break- through’ is appropriate at this stage of development of the RC. Numeric evaluation: 4 (Excellent)

2.10 Short description of how the RC members contributed the compilation of the stage 2 material

The processes employed were fair and appropriate.

2.11 How the UH’s focus areas are presented in the RC’s research

Focus area 6: Clinical research

The selected UH focus area 6 – ‘Clinical research’ – is appropriate for the research activities of the RC.

2.12 RC-specific main recommendations

The leading national status of the RC in its fields of research and doctoral training were recognized by the Panel and continuing activities are encouraged. In order to add value and to improve further the recognized quality of the work of the RC, major efforts, perhaps via a coordinated approach, should be made to publish the outputs of the research in high impact journals, where possible, which will raise the profile and international standing and status of the RC.

Whilst appreciating the importance of the areas of study and interest of the RC, some concern was expressed by the Panel regarding the breadth and scope of the research activities in this relatively small RC, and attention to this issue is recommended with consideration given to a more focused portfolio of topics. In addition, it is suggested that some clarification of supervisory processes and requirements for doctoral students would be beneficial. In order to broaden the range of funding opportunities for the group and encourage international standing and further contacts, it is suggested that efforts are directed towards securing access to EU funding perhaps via contributions to networks or grant applications, and consideration given to achieving value from the IP positions created by the RC from the translational research work.

2.13 RC-specific conclusions

The Panel was encouraged to note the evidence of the successes of the RC in their research and doctoral training programmes and recognize the potential for achieving a stronger international standing and position. A key issue in driving this factor is the publication of research findings in high impact journals and to secure external international support and funding, such as via EU networks and grants. The Panel was also of the view that given the size and dimension of the RC, attention should be given to refocusing the somewhat broad portfolio of their research activities, and the RC should reflect on the benefits of a consolidation of chosen topics which may be strengthened via cooperation with other RCs working in overlapping areas of interest.

3 Appendices

A. Original evaluation material a. Registration material – Stage 1 b. Answers to evaluation questions – Stage 2 c. List of publications d. List of other scientific activities B. Bibliometric analyses a. Analysis provided by CWTS/University of Leiden b. Analysis provided by Helsinki University Library (66 RCs)

International evaluation of research and doctoral training at the University of Helsinki 2005-2010

RC-SPECIFIC MATERIAL FOR THE PEER REVIEW

NAME OF THE RESEARCHER COMMUNITY: Cardiovascular Medicine (CardioMed)

LEADER OF THE RESEARCHER COMMUNITY: Professor Eero Mervaala, Institute of Biomedicine, Faculty of Medicine

RC-SPECIFIC MATERIAL FOR THE PEER REVIEW: Material submitted by the RC at stages 1 and 2 of the evaluation - STAGE 1 material: RC’s registration form (incl. list of RC participants in an excel table) - STAGE 2 material: RC’s answers to evaluation questions TUHAT compilations of the RC members’ publications 1.1.2005-31.12.2010 TUHAT compilations of the RC members’ other scientific activities 1.1.2005-31.12.2010 Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010 (analysis carried out by CWTS, Leiden University) NB! Since Web of Science(WoS)-based bibliometrics does not provide representative results for most RCs representing humanities, social sciences and computer sciences, the publications of these RCs will be analyzed by the UH Library (results available by the end of June, 2011)

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RC-SPECIFIC STAGE 1 MATERIAL (registration form)

1 RESPONSIBLE PERSON Name: Mervaala, Eero E-mail: Phone: 09-19125355 Affiliation: Institute of Biomedicine Street address: P.O.BOX 63 (Haartmaninkatu 8) 00014 University of Helsinki

2 DESCRIPTION OF THE PARTICIPATING RESEARCHER COMMUNITY (RC) Name of the participating RC (max. 30 characters): Cardiovascular Medicine Acronym for the participating RC (max. 10 characters): CardioMed Description of the operational basis in 2005-2010 (eg. research collaboration, joint doctoral training activities) on which the RC was formed (MAX. 2200 characters with spaces): CardioMed is a research community between several research groups working in the field of cardiovascular medicine. The research groups are located in the Institute of Biomedicine (pharmacology, physiology), and Department of Clinical Medicine. Cardiovascular Research in CardioMed is conducted in a highly interdisciplinary way, through a meaningful combination of basic and clinical research and international collaboration. CardioMed provides a framework in which researchers can carry out their scientific work at high level, and translate their findings into new forms of prevention, diagnostics, and therapies of cardiovascular diseases. The research community is based on long-lasting research collaboration between the principal investigators as well as on joint doctoral training. The research community combines their expertise on preclinical cardiovascular pharmacology and drug development, nutritional research and functional foods, regenerative therapy as well as on clinical medicine and hypertension genetics. Some of the principal investigators in CardioMed (professor Korpela, professor Mervaala and docent Tikkanen (coordinator)) are members of the Helsinki Hypertension Centre of Excellence (Helsinki University Central Hospital). Docent Kankuri, docent Tikkanen and professor Harjula are members of international Core-to-Core Program on Regenerative Therapy. The groups led by Professor Korpela and professor Mervaala have been selected as participants in a novel research consortium “Strategic Centre for Health and Wellbeing Salve Ltd”. The following group leaders are board members of the Finnish Hypertension Society (Mervaala (president), Tikkanen, Hiltunen).

3 SCIENTIFIC FIELDS OF THE RC Main scientific field of the RC’s research: medicine, biomedicine and healt sciences RC's scientific subfield 1: Cardiac and Cardiovascular System RC's scientific subfield 2: Pharmacology and Pharmacy RC's scientific subfield 3: Nutrition and Dietetics RC's scientific subfield 4: Medicine, Research and Experimental 1

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RC-SPECIFIC STAGE 1 MATERIAL (registration form)

Other, if not in the list:

4 RC'S PARTICIPATION CATEGORY Participation category: 2. Research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break-through Justification for the selected participation category (MAX. 2200 characters with spaces): CardioMed is a novel Research Community, the investigators are relatively young, and the size of the Research Community relatively small. Therefore the community has not yet been able to achieve strong international recognition or a clear break-through. Professor Mervaala was nominated as full-time professor of Cardiovascular and Metabolic Pharmacology in the Institute of Biomedicine in 2008, and professor Korpela as professor of Medical Nutrition Physiology later in 2008.

5 DESCRIPTION OF THE RC'S RESEARCH AND DOCTORAL TRAINING Public description of the RC's research and doctoral training (MAX. 2200 characters with spaces): The research activities in CardioMed are organized in 4 main topics: (1) Cardiovascular pharmacology, (2) Regenerative therapy, (3) Nutrition/functional foods, (4) Clinical cardiology/hypertension genetics. Cardiovascular Pharmacology Group led by professor Eero Mervaala. The group investigate the molecular mechanisms of cardiac hypertrophy and heart failure with a special interest on local renin-angiotensin system, inflammation, novel angiogenic factors (VEGF-family members), mitochondrial function, and drug development (calcium sensitizers, in collobaration with pharmaceutical industry). Regenerative Therapy led by docent Esko Kankuri and professor Ari Harjula. Kankuri’s and Harjula’s groups participate on international Core-to-Core Program on Regenerative Therapy aiming at construction of cardiac tissue using integrated gene, cell, and tissue engineering technology and its application for the treatment of cardiac failure. Nutrition/Functional Foods is led by professor Riitta Korpela and professor Heikki Vapaatalo. Korpela’s group is regarded as one of the frontier groups in the area of functional foods. The group uses both in vitro and animal models and has a long experience in clinical trials. Both groups will investigate pharmacological and physiological effects of novel milk protein-derived biopeptides in preclinical and clinical studies. They aim at developing novel antihypertensive and cholesterol-lowering functional food items in collaboration with food industry. Clinical cardiology/hypertension genetics is led by docent Ilkka Tikkanen. Tikkanen acts also as the coordinator of Helsinki Hypertension Centre of Excellence in Helsinki University Central Hospital. Tikkanen’s group studies end-organ and tissue damage secondary to cardiovascular, heart and kidney diseases and the molecular mechanisms involved herein. Docent Jukka Lehtonen’s research interest lies within renin- angiotensin system and inflammatory heart diseases. Docent Timo Hiltunen’s research covers monogenic forms and pharmacogenetics of hypertension. Significance of the RC's research and doctoral training for the University of Helsinki (MAX. 2200 characters with spaces): CardioMed’s research is interdisciplinary and translational, and combines basic and clinical research. The RC produces experts in the several fields (in particular pharmacology), with high employment opportunity in the Finnish Medicines Agency or in the pharmaceutical/food industry. 2

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RC-SPECIFIC STAGE 1 MATERIAL (registration form)

CardioMed has an excellent track record in doctoral training and mentoring, and the members of CardioMed have are very actively taken part into teaching duties in the Medical Faculty. CardioMed provides an excellent infrastructure for integrated Cardiovascular Medicine and translational research. CardioMed addresses areas of general public interest and impact, as cardiovascular diseases are the leading cause of death and disability in the developed countries. Keywords: Cardiovascular pharmacology; Regenerative medicine, Cell therapy, Personalized medicine; Pharmacogenetics; Drug development; Nutrition; Functional foods; Metabolism; Translational Research; Inflammation

6 QUALITY OF RC'S RESEARCH AND DOCTORAL TRAINING Justified estimate of the quality of the RC's research and doctoral training at national and international level during 2005-2010 (MAX. 2200 characters with spaces): CardioMed is a novel Research Community, and therefore the quality of CardioMed’s research and doctoral training has not been evaluated with justification during the period under evaluation. However, all the research groups have received substantial external funding during the period under evaluation (Academy of Finland, Sigrid Juselius Foundation, National Technology Agency, University of Helsinki, Helsinki University Central Hospital) indicating high quality of their research and doctoral training. Comments on how the RC's scientific productivity and doctoral training should be evaluated (MAX. 2200 characters with spaces): For methods of assessing CardioMed’s scientific productivity and doctoral training we suggest the following: 1) amount of external funding, 2) number of doctoral candidates who have finished their PhD studies during the period under evaluation, 3) number of publications and quality of the publications, 4) number of patents/patent applications. It should also be underlined that all principal investigators, post-doctoral researchers and doctoral candidates working in the Institute of Biomedicine have a substantial amount of teaching duties, since Institute of Biomedicine is responsible for the first two years’ courses for medical students and dentists, as well as for TRANSMED-Master of Science program. Such teaching load should be taken into consideration when evaluating the CardioMed research community.

LIST OF RC MEMBERS

NAME OF THE RESEARCHER COMMUNITY: CardioMed RC-LEADER E. Mervaala CATEGORY 2 PI-status (TUHAT- check, Title of research and Last name First name lista 29.11.) teaching personnel Affiliation 1 Mervaala Eero x Professor Faculty of Medicine, Institute of Biomedicine 2 Korpela Riitta x Professor Faculty of Medicine, Institute of Biomedicine 3 Vapaatalo Heikki x Professor Faculty of Medicine, Institute of Biomedicine 4 Harjula Ari x Professor Faculty of Medicine, Institute of Clinical Medicine 5 Tikkanen Ilkka x Research Director Faculty of Medicine, Institute of Clinical Medicine 6 Kankuri Esko x Senior Researcher Faculty of Medicine, Institute of Biomedicine 7 Laine Mika Senior Researcher Faculty of Medicine, Institute of Clinical Medicine 8 Finckenberg Piet Post-doctoral Researcher Faculty of Medicine, Institute of Biomedicine 9 Louhelainen Marjut Doctoral candidate Faculty of Medicine, Institute of Biomedicine 10 Biala Agnieszka Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 11 Ketonen Juha Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 12 Kaheinen Petri Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 13 Pilvi Taru Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 14 Pere Anna-Kaisa Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 15 Vahtola Erik Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 16 Tauriainen Eveliina Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 17 Shi Jin Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 18 Lempiäinen Juha Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 19 Ehlers (neé Jäkälä) Pauliina Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 20 Jauhiainen Tiina Post-doctoral researcher Faculty of Medicine, Institute of Biomedicine 21 Lakkisto Päivi Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 22 Paavola Jere Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 23 Forsten Hanna Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 24 Segersvärd Heli Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 25 Siren Juuso Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 26 Bäcklund Tom Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 27 Grönholm Tina Doctoral Candidate Faculty of Medicine, Institute of Clinical Medicine 28 Siltanen Antti Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 29 Nuutila Kristo Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 30 Peura Matti Doctoral Candidate Faculty of Medicine, Institute of Biomedicine 31 Aarnio Karoliina Doctoral Candidate Faculty of Medicine, Institute of Biomedicine

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RC-SPECIFIC STAGE 2 MATERIAL

BACKGROUND INFORMATION Name of the RC’s responsible person: Mervaala, Eero E-mail of the RC’s responsible person: Name and acronym of the participating RC: Cardiovascular Medicine, CARDIOMED The RC’s research represents the following key focus area of UH: 6. Kliininen tutkimus – Clinical research Comments for selecting/not selecting the key focus area: Part of the RC’s research represents very closely one of the key focus areas of UH, namely clinical research. However, it should be underlined that the RC’s research also represents basic and translational research in cardiovascular and nutritional medicine.

1 FOCUS AND QUALITY OF RC'S RESEARCH (MAX. 8800 CHARACTERS WITH SPACES)

Description of the RC’s research focus, the quality of the RC’s research (incl. key research questions and results) and the scientific significance of the RC’s research for the research field(s). Cardiovascular diseases represent a major public health problem and the leading cause of death in Finland. RC provides a highly interdisciplinary framework in which cardiovascular research can be carried out at high level aiming at translation of novel innovations into medical applications. RC’s research addresses clinically important issues such as hypertension, metabolic syndrome, left ventricular hypertrophy, myocardial infarction and heart failure. RC has also a strong interest on nutrition, regenerative medicine and personalized drug therapy (“pharmacogenetics”).

RC’s research activities are organized in 4 main topics: 1) Cardiovascular and Metabolic Pharmacology and drug development, 2) Regenerative Medicine, 3) Medical Nutrition Physiology and development of functional foods, and 4) Clinical cardiology, hypertension genetics and personalized drug therapy.

Cardiovascular Pharmacology Group (Institute of Biomedicine, Principal Investigator (PI) prof. Eero Mervaala) investigates the pathophysiology of hypertension and the molecular mechanisms of cardiac hypertrophy and post-infarct heart failure as well as the mechanisms of cardiovascular aging (funded by Academy of Finland 2008-2011). The group showed a key role for local renin-angiotensin system in the pathogenesis of cardiac remodelling and cardiovascular aging. It was shown that angiotensin II induces oxidative stress, inflammation and mitochondrial dysfunction by blood pressure- independent mechanisms. Metabolomics analysis revealed distinct energy substrate utilization in cardiac hypertrophy. The group has evaluated the potential of novel oral calcium sensitizers in the treatment of heart failure (two patents). In collaboration with prof. Kari Alitalo’s group we have investigated the role of angiogenic factors as coronary growth factors and regulators of cardiac growth and metabolism. It was found that VEGF-B acts as a growth factor without inducing angiogenesis, vascular leak, or inflammation. VEGF-B also altered lipidomic profile in the heart and induced cardiac hypertrophy via blood pressure-independent mechanisms. The group has collaborated with food industry to generate novel nutritional strategies to combat obesity (one patent) and to develop novel salt alternatives for hypertension control (patent application). Finally, the group has started a project to investigate the therapeutic role of small molecule compounds and stem cells in acute kidney injury. Prof. Mervaala has supervised 6 PhD theses between years 2005-2010, and four PhD thesis will be finished in year 2011 (under evaluation).

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RC-SPECIFIC STAGE 2 MATERIAL

Regenerative Pharmacology Group (Institute of Biomedicine/Institute of Clinical Medicine). The team led by professor Ari Harjula and docent Esko Kankuri focuses on cardiac regenerative therapies using cell sheet technology, nemosis-activated fibroblasts, stem and precursor cells. Cell sheets that are transplanted topically on myocardium help to solve the problem of fatal arrhythmias as associated with intramyocardial cell injections. Using this technique we have shown for example that bcl-2-mediated anti-apoptotic protection helps early myoblast sheet survival. Our preclinical research focuses on development of methodology (gene therapy, pharmacotherapy) to enhance regenerative cell sheet transplantation therapy. Furthermore we aim at discovery of functional indicators and molecular predictors of cell transplant clinical efficacy. In May 2011 we will complete a randomized double-blinded clinical trial on intramyocardial stem cell transplantation at coronary artery bypass graft surgery. The study provides the first placebo-controlled evidence using functional cardiac magnetic-resonance imaging on the efficacy of unfractionated bone marrow precursor cell transplantation therapy in heart failure patients. We have also established a “Core-to-Core Consortium” together with professor Axel Haverich from the Hannover Medical School, Division of Thoracic & Cardio Surgery, Hannover, Germany and with professor Yoshiki Sawa from the Osaka University Graduate School of Medicine, Osaka, Japan. The aim is to provide clinical proof of concept for heart failure therapy using autologous myoblast and bone marrow stromal/stem cell sheets. We coordinate additional five European clinical cardiac centers and cell sheet manufacturing at Finnish Red Cross Blood Service.

Medical Nutrition Physiology Group (Institute of Biomedicine, PIs prof. Riitta Korpela and prof. Heikki Vapaatalo) combines translational research to clinical medicine. The group investigates health effects of nutritional components (milk, berries, plant sterols) and their mechanisms of action. The main focus has been on milk casein-derived tripeptides (Ile-Pro-Pro, Val-Pro-Pro). The group has shown in experimental models of hypertension, that milk tripeptides decrease blood pressure and improve vascular function. The mechanisms mediating the antihypertensive and vasculoprotective effects of milk tripeptides involve inhibition of angiotensin converting enzyme, central regulation of blood pressure and vascular homeostasis (one patent). Recently, the group has examined the effects of tripeptides on neurodegeneration and retinal blood flow in collaboration with pharmaceutical industry (Santen, Pharmatory) (one patent). The group has participated in several clinical studies where the antihypertensive effect of tripeptides was demonstrated in mildly hypertensive subjects. These findings have been translated into novel functional food items that are in the market in EU and Japan. Prof. Vapaatalo has supervised 3 PhD theses (plus 2 PhD projects in progress) and has produced more than 30 original articles on milk peptides between years 2005-2010. Prof. Korpela has supervised 8 PhD theses during the evaluation period, and currently she acts also as a coordinator in a novel research consortium “Strategic Centre for Health and Wellbeing SalWe Ltd”.

Unit of Cardiovascular Research (Institute of Clinical Medicine/ Minerva Foundation Institute for Medical Research, PI docent Ilkka Tikkanen). The group studies mechanisms and repair of end-organ damage in cardiovascular and renal diseases in experimental animals and clinical trials. In this context the local expression of components of the renin-angiotensin-aldosterone system, other vasoactive factors and apoptosis in hypertension, heart failure, and in progression of renal damage has been studied. In addition, the cardiovascular and renal protective properties of new cardiovascular drugs have been evaluated. The group was able to demonstrate that calcium signalling in cardiac cells is altered in familial catecholaminergic polymorphic ventricular tachycardia due to mutated ryanodine receptors predisposing to cardiac arrhythmias in these patients. The group showed that the activity of bradykinin degrading enzyme neutral endopeptidase was increased in stenotic aortic valves in parallel with increased expression of bradykinin receptors suggesting a therapeutic role for NEP-inhibitory compounds. In clinical hypertension projects in collaboration with prof. Kimmo Kontula it was shown that 1) the CYP2C9 genotype modifies the activity of the renin-angiotensin-aldosterone system and 2)

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RC-SPECIFIC STAGE 2 MATERIAL

AGTR1 1166C allele is associated with high serum aldosterone levels and low plasma renin activity in patients with essential hypertension. Recently, the Unit has focused on exploring the reparative mechanisms of cardiac injury after myocardial infarction. These studies showed that induction heme oxygenase-1 promotes cardiomyocyte regeneration and angiogenesis after MI.

Ways to strengthen the focus and improve the quality of the RC’s research. -to deepen the already existing, already working collaboration within the RC -to strengthen the translational research approach in the RC by applying the methodology and hypotheses created in basic studies to clinical research questions utilizing the available collaboration and patient materials in the University Hospital Clinics (Cardiology, Thoracic surgery) and through the network within the Helsinki Hypertension Centre of Excellence -to strengthen the current collaboration with research groups in research programs in UH (Prof. Kimmo Kontula, Research Program of Molecular Medicine; prof. Kari Alitalo, Research Program of Molecule and Cancer Biology) as well with the groups working in the field of obesity, diabetes, mitochondria and lipids -to strengthen the collaboration with our international collaborators -to initiate a PhD Study seminar common to all members of the RC. Seminars will be given by PhD students, researchers participating in the RC, and invited speakers. - Post-doctoral fellows and international collaboration would strengthen the research.

2 PRACTISES AND QUALITY OF DOCTORAL TRAINING (MAX. 8800 CHARACTERS WITH SPACES)

How is doctoral training organised in the RC? Description of the RC’s principles for recruitment and selection of doctoral candidates, supervision of doctoral candidates, collaboration with faculties, departments/institutes, and potential graduate schools/doctoral programmes, good practises and quality assurance in doctoral training, and assuring good career perspectives for the doctoral candidates/fresh doctorates. Recruitment and selection of doctoral candidates is based on their excellence in undergraduate studies and/or MSc thesis, or an open call.

PhD students in the RC usually have two supervisors of different disciplines and a PhD Thesis Committee. The PhD Thesis Committee includes the student, the supervisor(s), and at least two external members representing top class specialists in different disciplines. The Members of the PhD Thesis Committee are suggested by the student and supervisor, and accepted by the Faculty of Medicine. The external members should have substantial knowledge of the field of the project in order to be able to give critical comments and to estimate the ongoing project's potential to result in thesis defense. The PhD Thesis Committee is keeping regular meetings at least once a year.

The supervisors together with the PhD Thesis Committee are responsible of ensuring that during the PhD studies the student gains detailed knowledge of his/her research field as well as adequate understanding of the related fields of biomedicine. Like in graduate schools, the goal for the PhD student is to achieve a doctoral degree within a four-year period.

PhD students generate a personal study plan including both research and coursework. Following this the PhD project is registered at the Faculty of Medicine.

PhD students in the RC will get their theoretical postgraduate training mainly via participating in the courses organized by graduate schools and department programs as well as the courses coordinated by 3

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RC-SPECIFIC STAGE 2 MATERIAL

the Faculty of Medicine. The graduate schools also organize a wide variety of practical training courses, seminar series, and scientific symposia for graduate students.

Each research group in the RC is organizing their own weekly group meetings. PhD students participate actively on these regular meetings.

The Institutes (Institute of Biomedicine, Institute of Clinical Medicine and Minerva Foundation Institute for Medical Research) are organizing weekly post-graduate seminar series for PhD students. Institute of Biomedicine (Pharmacology) is organizing an annual follow-up meeting for PhD students. In this meeting PhD students give presentations on their research project.

PhD students are encouraged to participate in international meetings and congresses, and represent their work there. Travel costs are covered mainly by the research groups, and to some extent, by travel grants.

A close dialogue with other universities, industry and ”the third sector” is maintained via our own post- docs working there and still collaborating with the RC group, as well as by inviting key researchers in the field to give lectures in our Institute. For industry, mutual interest and successful joint research projects with PhD students are important means to recruit potential new employees. Seven of the eight PhDs graduated from Medicinal Nutrition Physiology Group during the evaluation time are employed by industry at the moment. RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development. The strength of our RC is the close collaboration with industry and the third sector. International exchange is also increasing both via in-coming and out-coming students.

Several PhD students from our RC were recruited to pharmaceutical and food industry as well as to Finnish Medicines Agency during the evaluation period indicating high quality of our doctoral training, and our capacity to generate experts in the field of pharmacology and medical nutrition.

Most of the research groups utilize PhD Student Committees in the supervision and follow-up of PhD students. PhD students participate actively and regularly in group meetings, department meetings as well as the courses organized by the graduate schools.

There is a substantial lack of coherent research career development possibilities (post-doc positions), although the tenure track system was very recently started in the University of Helsinki.

3 SOCIETAL IMPACT OF RESEARCH AND DOCTORAL TRAINING (MAX. 4400 CHARACTERS WITH SPACES)

Description of how the RC interacts with and contributes to the society (collaboration with public, private and/or 3rd sector). Members of the RC form the nucleus of Helsinki Hypertension Centre of Excellence. The Helsinki Hypertension Centre of Excellence is part of the European Hypertension Excellence Centre network of the European Society of Hypertension (ESH). It was approved by ESH in June 17, 2008, serves the Hospital District of Helsinki and Uusimaa, and collaborates nationally with Turku Hypertension Centre and Tampere University Hospital. Within the centre, it collaborates with all specialities involved in hypertension and hypertension related cardiovascular diseases (diagnosis, prevention, treatment, education and research). 4

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

Leading doctors/scientists Speciality •Ilkka Tikkanen*, docent, head – nephrology •Frej Fyhrquist*, professor(emer) – internal medicine •Timo Hiltunen, docent – hypertension genetics, internal medicine •Eero Honkanen, docent – nephrology •Olli Häppölä, docent – neurology •Ilkka Immonen, docent – ophthalmology •Hannu Jalanko, professor – pediatrics •Risto Kaaja*, professor –hypertension in women/obstetric hypertension •Kimmo Kontula*, professor – hypertension genetics, internal medicine •Riitta Korpela, professor – nutritional physiology •Mauri Lepäntalo, professor – vascular surgery •Eero Mervaala, professor – cardiovascular and metabolic pharmacology •Markku S. Nieminen*, professor – cardiology •Tuula Tikkanen*, docent – internal medicine/general practise •Matti Välimäki, professor – endocrinology *clinical hypertension specialists of the European Society of Hypertension

Hospital/Research locations: • Helsinki University Central Hospital (departments of nephrology, cardiology, endocrinology, vascular surgery, neurology, ophthalmology, pediatrics, and obstetrics & gynaecology) • Helsinki City Hospital Laakso (outpatient clinics) • Biomedicum Helsinki, University of Helsinki

Finnish Hypertension Society - Eero Mervaala, current president and board member - Ilkka Tikkanen, past president and board member - Finnish Hypertension Society has vast societal impact: It is responsible for current care guidelines, organizes post-graduate training and education, and public counselling

Finnish Nutrition Society - Riitta Korpela, current president and board member Prof. Korpela is the chairman of the Finnish Society of Nutrition Science and a Finnish representative in the European Joint Programming initiative “ A healthy diet for a healthy life”.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

The Medical Nutrition Physiology Group leads a Tekes-funded project (Valio, Unilever, DSM, Finnish Red Cross, Oriola) and is a participant in the industry-lead Health and Wellness SHOK program. The group is partner of the European Science Foundation funded European Network for Gastrointestinal Health Research. Ways to strengthen the societal impact of the RC’s research and doctoral training. Participation in the TEKES-funded SHOK program.

Increasing visibility by organizing public presentations and open seminars and by writing popular articles.

Taking actively part into the actions organized by Helsinki Hypertension Centre of Excellence, Finnish Hypertension Society, and Finnish Nutrition Society.

4 INTERNATIONAL AND NATIONAL (INCL. INTERSECTORAL) RESEARCH COLLABORATION AND RESEARCHER

MOBILITY (MAX. 4400 CHARACTERS WITH SPACES)

Description of the RC’s research collaborations and joint doctoral training activities and how the RC has promoted researcher mobility. Cardiovascular Pharmacology Group National Collaborators (outside CARDIOMED) Kari Alitalo, professor, research program of Molecule and Cancer Biology Matti J. Tikkanen, professor (UH) Matej Oresic, professor (Technical Research Centre of Finland) Karl-Heinz Herzig, professor (University of Oulu) Ove Eriksson, docent (UH) RIsto Lapatto, docent (Helsinki University Hospital) Collaboration with pharmaceutical industry: Orion Pharma Collaboration with food industry: Valio Main International Collaborators Profs. Friedrich Luft, Michael Bader, Dominik Muller, Max DelBruck Center for Molecular Medicine (MDC), Berlin, Germany Jens Titze, MD, PhD, University of Erlangen, Germany Ramaroson Andriatsitohaina, MD, PhD, University of Angers, France.

Prof. Mervaala is currently hosting one visiting PhD student from Russia (Alyona Inczhutova, MD, CIMO fellowship for 18 months) and one PhD student from Italy (Alice Bradachia, MSc, 6 months).

Regenerative Pharmacology Group National collaborators (outside CARDIOMED) Finnish Red Cross Blood Service (Senior Medical Officer Matti Korhonen) Regea Institute for Regenerative Medicine (Docent Susanna Miettinen) 6

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

International collaborators Osaka University Graduate School of Medicine, Japan (Prof. Yoshiki Sawa) Hannover Medical School, Germany (prof. Axel Haverich) Slovak Academy of Sciences (DSc Jozef Bizik)

Medical Nutrition Physiology Group International collaboration with University of Strasbourg and INRA, Toulouse, France. National collaboration with National Institute for Health and Welfare, Hospital District of Helsinki and Uusimaa, Finnish Institute of Occupational Health and Institute of Medical Technology, University of Tampere. Joint doctoral training with INRA France and in 2011 also University of Cork, Ireland. One PhD student (Hanne Keränen) is working in INRA France since December 2009. Pauliina Ehlers performed one experiment in Strasbourg University. Other short visits have been performed during the evaluation time in Strasbourg University and INRA France.

Unit of Cardiovascular Research Collaborators (national): Ari Harjula, Professor (Helsinki University Hospital) Esko Kankuri, Docent (University of Helsinki) Markku Kupari, Professor (Helsinki University Hospital) Eero Mervaala, Professor (University of Helsinki) Kari Pulkki, Professor (University of Kuopio) Ilkka Pörsti, Professor (University of Tampere) International collaboration/research mobility: European Society of Hypertension Excellence Centre Network: Clinical Hypertension Trials Jere Paavola acted as a visiting research fellow at the Yale University School of Medicine, New Haven, CT, USA, 10/2008-4/2010

The RC has also promoted researcher mobility via recruitment of PhD students from pharmaceutical and food industry. RC has taken a strong responsibility to provide doctoral training in Pharmacology and Medical Nutrition for its PhD students. Several previous PhD students of the RC have been recruited in pharmaceutical industry, food industry as well as in Finnish Medicines Agency during the evaluation period. RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development. The RC has a very wide colloboration network both nationally as well as internationally which enables researcher mobility.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

The European Science Foundation funded European Network for Gastrointestinal Health Research will give opportunities and grants to student exchange programs. An international winter school for PhD students in the field of nutrition and inflammation was organized by the RC in 2009 and the second one will be organized in 2012.

5 OPERATIONAL CONDITIONS (MAX. 4400 CHARACTERS WITH SPACES)

Description of the operational conditions in the RC’s research environment (e.g. research infrastructure, balance between research and teaching duties). The RC has adequate and modern laboratory space in the Institute of Biomedicine, Institute of Clinical Medicine and Minerva Foundation Institute for Medical Research, and either possess or have access to a number of state-of-the-art equipment and technologies (Biomedicum Helsinki Core facility Units). Clinical Research is conducted in the Institute of Clinical Medicine / Helsinki University Hospital. Funding of novel equipments is based on applications for funding submitted to “infrastructural calls” opened by UH, Academy of Finland, or locally by the Institute of Biomedicine.

All principal investigators have a substantial amount of teaching duties in their Institutes. Every PhD student also participates to some extent to teaching duties (max. 40 hours per year). RC’s strengths and challenges related to operational conditions, and the actions planned for their development. The RC has been successful in getting external funding.

RC’s research activities are dependent on competitive external and complementary short-term funding, and therefore grant applications demand a significant part of the principal investigator’s time. All principal investigators have a substantial amount of teaching duties in their Institutes.

6 LEADERSHIP AND MANAGEMENT IN THE RESEARCHER COMMUNITY (MAX. 4400 CHARACTERS WITH SPACES)

Description of the execution and processes of leadership in the RC, how the management-related responsibilities and roles are distributed in the RC and how the leadership- and management-related processes support high quality research, collaboration between principal investigators and other researchers in the RC, the RC’s research focus and strengthening of the RC’s know-how. The research carried out in the RC is based on the principle that research groups enjoy independence of action. Scientific research in the groups is driven by the principal investigators. Principal investigators are also responsible for obtaining external funding for their research and leading their research group following their strategic research plans. As all the principal investigators are affiliated either to Institute of Biomedicine, Institute of Clinical Medicine or Minerva Foundation Institute for Medical Research, the RC receives to some extent technical and administrative support from the Institutes’ budget funding. RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes. RC’s research is multidisciplinary and translational, which can be considered as a strength of the RC. Members of the RC are young, team leaders innovative, and there is an open dialogue and collaboration between different research groups within the RC, as well as with other reseach groups working in the same field.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

There is a substantial lack of coherent research career development possibilities (i.e. post-doctoral positions), although the tenure track system was very recently started in the University of Helsinki.

7 EXTERNAL COMPETITIVE FUNDING OF THE RC

Listing of the RCs external competitive funding, where: - the funding decisions have been made during 1.1.2005-31.12.2010, and - the administrator of the funding is/has been the University of Helsinki

Academy of Finland (AF) - total amount of funding (in euros) AF has decided to allocate to the RC members during 1.1.2005-31.12.2010: 363250

Finnish Funding Agency for Technology and Innovation (TEKES) - total amount of funding (in euros) TEKES has decided to allocate to the RC members during 1.1.2005-31.12.2010: 1341279

European Union (EU) - total amount of funding (in euros) EU has decided to allocate to the RC members during 1.1.2005-31.12.2010:

European Research Council (ERC) - total amount of funding (in euros) ERC has decided to allocate to the RC members during 1.1.2005-31.12.2010:

International and national foundations – names of international and national foundations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros). - names of the foundations: Sigrid Juselius Foundation, Päivikki ja Sakari Sohlberg Foundation, Finnish Foundation for Cardiovascular Research - total amount of funding (in euros) from the above-mentioned foundations: 334500

Other international funding - names of other international funding organizations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros). - names of the funding organizations: - total amount of funding (in euros) from the above-mentioned funding organizations:

Other national funding (incl. EVO funding and Ministry of Education and Culture funded doctoral programme positions) - names of other national funding organizations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros). - names of the funding organizations: EVO-funding, pharmaceutical industry, food industry, University of Kuopio Funds, University of Helsinki Funds - total amount of funding (in euros) from the above-mentioned funding organizations: 1754896

8 RC’S STRATEGIC ACTION PLAN FOR 2011–2013 (MAX. 4400 CHARACTERS WITH SPACES)

Description of the RC’s future perspectives in respect to research and doctoral training. The mission of the RC is to elucidate novel therapeutic targets and to develop safer and more efficient prevention and intervention strategies for cardiovascular disease continuum.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 2 MATERIAL

Main focus of RC’s research will be a more comprehensive, translational approach to cover the ‘cardiovascular disease continuum’ from risk factors (including diet and dietary interventions) and genetic background to prevention and treatment of cardiac, vascular and renal end organ damage and dysfunction.

Aims and tools: -further development and strengthening of the existing versatile basic methodology and collaboration -utilization and application of novel experimental models (e.g. zebra fish methodology, cell cultures including iPS-cells, gene expression and transfection studies) and tools (genomics - miRNA/transcriptomics – proteomics – metabolomics), -more systematic application of basic findings and methodology to clinical patient materials and questions to improve early diagnostic and prognostic evaluation (application of genomics - miRNA/transcriptomics – proteomics – metabolomics) as well as tailored prevention treatment of cardiovascular diseases -collaboration with University Hospital Clinics -utilization of the Helsinki Hypertension Centre of Excellence network (national, international) -to initiate a PhD Study seminar common to all members of the RC. Seminars will be given by PhD students, researchers participating in the RC, and invited speakers. -Principal investigators are encouraged to use more frequently PhD Thesis Committees, and to utilize more structural forms to follow the progress of the PhD thesis like in the graduate schools -the visibility of the research carried out in RC is increased through high-level publications and active participation in scientific meetings. -Principal investigators are encouraged to take full use of their national and international contacts to attract promising post-doctoral students to our RC.

9 SHORT DESCRIPTION OF HOW THE RC MEMBERS HAVE CONTRIBUTED TO THE COMPILATION OF THE STAGE 2 MATERIALS (MAX. 1100 CHARACTERS WITH SPACES). All principal investigators have contributed to the compilation of the stage 2 materials by providing detailed information on their research activities and doctoral training to the responsible person (Prof. Mervaala). All principal investigators have also contributed to the writing of the strategic action plan for 2011-2013.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

1 Analysis of publications

- Associated person is one of Eero Mervaala , Riitta Anneli Korpela , Heikki Vapaatalo , Ari Harjula , Ilkka Tikkanen , Esko Markus Kankuri , Mika Laine , Piet Matias Finckenberg , Marjut Anneli Louhelainen , Agnieszka Biala , Juha Ketonen, Taru Kyllikki Pilvi , Erik Vahtola , Eveliina Tauriainen , Jin Shi , Pauliina Ehlers , Päivi Lakkisto , Jere Paavola , Antti Markus Siltanen , Kristo Nuutila , Matti Peura ,

Publication year

Total Count 2005 - Publication type 2005 2006 2007 2008 2009 2010 2010

A1 Refereed journal article 34 20 33 37 32 31 187

A2 Review in scientific journal 1 3 1 5 10

A3 Contribution to book/other compilations (refereed) 1 2 1 4

A4 Article in conference publication (refereed) 1 2 1 1 1 6

B1 Unrefereed journal article 3 5 4 1 4 1 18

C2 Edited book, compilation, conference proceeding or special issue of 1 1 1 3 journal

D2 Article in professional hand or guide book or in a professional data 2 1 3 system, or text book material

E1 Popular article, newspaper article 4 1 3 8

H1 Patents 1 1 2

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

2 Listing of publications

A1 Refereed journal article

2005 Chapman, H, Korhonen, L, Ramstrom, C, Laine, M, Wann, KT, Lindholm, D, Pasternack, M, Tornquist, K 2005, 'Downregulation of the HERG (KCNH2) K+ channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation', Journal of Cell Science, vol 118, pp. 5325-5334. Cheng, ZJ, Grönholm, T, Louhelainen, M, Finckenberg, P, Merasto, S, Tikkanen, I, Mervaala, E 2005, 'Vascular and renal effects of vasopeptidase inhibition and angiotensin-converting enzyme blockade in spontaneously diabetic Goto-Kakizaki rats', Journal of Hypertension, vol 23, pp. 1757-1770. Cheng, ZJ, Vapaatalo, H, Mervaala, E 2005, 'Angiotensin II and vascular inflammation', Medical Science Monitor, vol 11, no. 6, pp. RA194-RA205. Cheng, S, Lyytikäinen, A, Kröger, H, Lamberg-Allardt, C, Alen, M, Koistinen, A, Wang, QJ, Suuriniemi, M, Suominen, H, Mahonen, A, Nicholson, PHF, Ivaska, KK, Korpela, R, Ohlsson, C, Väänänen, KH, Tylavsky, F 2005, 'Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial¹³', American Journal of Clinical Nutrition, vol 82, no. 5, pp. 1115-1126. Dugo, L, Collin, M, Allen, D, Patel, N, Bauer, I, Mervaala, E, Louhelainen, M, Foster, S, Yaqoob, M, Thiemermann, C 2005, 'GSK-3[beta] inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat', Critical Care Medicine, vol 33, no. 9, pp. 1903- 1912. Eerola, L, Alho, H, Maasilta, P, Inkinen, K, Harjula, A, Litmanen, S, Salminen, U 2005, 'Matrix metalloproteinase induction in post- transplant obliterative bronchiolitis', Journal of Heart and Lung Transplantation, vol 24, no. 4, pp. 426-432. Finckenberg, P, Merasto, S, Louhelainen, M, Lindgren, L, Vapaatalo, H, Muller, D, Luft, F, Mervaala, E 2005, 'Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression', Journal of Hypertension, vol 23, pp. 375-380. Grönholm, T, Cheng, ZJ, Palojoki, E, Eriksson, A, Bäcklund, T, Vuolteenaho, O, Finckenberg, P, Laine , M, Mervaala, E, Tikkanen, I 2005, 'Vasopeptidase inhibition has beneficial cardiac effects in spontaneously diabetic Goto-Kakizaki rats', European Journal of Pharmacology, vol 519, pp. 267-276. Hannila-Handelberg, T, Kontula, K, Tikkanen, I, Tikkanen, T, Fyhrquist, F, Helin, K, Fodstad, H, Piippo, K, Miettinen, HE, Virtamo, J, Krusius, T, Sarna, S, Gautschi, I, Schild, L, Hiltunen, TP, Hannila-Handerberg, T 2005, 'Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension', BMC Medical Genetics, vol 6. Jauhiainen, T, Collin, M, Narva, M, Cheng, ZJ, Poussa, T, Vapaatalo, H, Korpela, R 2005, 'Effect of long-term intake of milk peptides and minerals on blood pressure and arterial function in spontaneously hypertensive rats', Milchwissenschaft, vol 60, pp. 358-363. Jauhiainen, T, Vapaatalo, H, Poussa, T, Kyrönpalo, S, Rasmussen, M, Korpela, R 2005, 'Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement', American Journal of Hypertension, vol 18, pp. 1600-1605. Kajander, K, Hatakka, K, Poussa, T, Färkkilä, M, Korpela, R 2005, 'A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention', Alimentary Pharmacology & Therapeutics, vol 22 (, pp. 387-394. Kankuri, E, Cholujova, D, Comajova, M, Vaheri, A, Bizik, J 2005, 'Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness', Cancer Research, vol 65, no. 21, pp. 9914-9922. Karppanen, H, Mervaala, E, Klaukka, T 2005, 'Miksi väestön kolesteroliarvot kohoavat, vaikka statiinien käyttö yleistyy?', Suomen lääkärilehti , vol 60, no. 47, pp. 4874-4875. Karppanen, H, Karppanen, P, Mervaala, E 2005, 'Why and how to implement sodium, potassium, calcium, and magnesium changes in food items and diets?', Journal of Human Hypertension, vol 19, pp. S10-S19. Ketonen, J, Merasto, S, Paakkari, I, Mervaala, E 2005, 'High sodium intake increases vascular superoxide formation and promotes atherosclerosis in apolipoprotein E-deficient mice', Blood Pressure, vol 14, pp. 373-382. Klemola, T, Kalimo, K, Poussa, T, Juntunen-Backman, K, Korpela, R, Valovirta, E, Vanto, T 2005, 'Feeding a soy formula to children with cow's milk allergy: the development of immunoglobulin E-mediated allergy to soy and peanuts', Pediatric Allergy and Immunology, vol 16, no. 8, pp. 641-646. Korpela, R, Paajanen, L, Tuure, T 2005, 'Homogenization of milk has no effect on the gastrointestinal symptoms of lactose intolerant subjects', Milchwissenschaft, vol 60, pp. 3-6.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Lehto, JT, Lemström, K, Halme, M, Lappalainen, M, Lommi, J, Sipponen, J, Harjula, A, Tukiainen, P, Koskinen, PK 2005, 'A prospective study comparing cytomegalovirus antigenemia, DNAemia and RNAemia tests in guiding pre-emptive therapy in thoracic organ transplant recipients', Transplant International, vol 18, pp. 1318-1327. Lehto, J, Lemström, KB, Halme, M, Lappalainen, M, Lommi, J, Sipponen, J, Harjula, A, Tukiainen, PS, Koskinen, P 2005, 'A prospective study comparing cytomegalovirus antigenemia, DNAemia (PCR) and RNAemia (NASBA) test in guiding pre-emptive therapy in thoracic organ transplant recipients.', Transplant International, vol 18, pp. 1318-1327. Malinen, E, Rinttilä, T, Kajander, K, Mättö, J, Lyra, A, Krogius-Kurikka, LK, Saarela, M, Korpela, R, Palva, A 2005, 'Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR', American Journal of Gastroenterology, vol 100, no. 2, pp. 373-382. Myllyluoma, E, Veijola, L, Ahlroos, T, Tynkkynen, S, Kankuri, E, Vapaatalo, H, Rautelin, H, Korpela, R 2005, 'Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy: a placebo-controlled, double-blind randomized pilot study', Alimentary Pharmacology & Therapeutics, vol 21, pp. 1263-1272. Mättö, J, Maunuksela, L, Kajander, K, Palva, A, Korpela, R, Kassinen, A, Saarela, M 2005, 'Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome: a longitudinal study in IBS and control subjects', FEMS Immunology and Medical Microbiology, vol 43, pp. 213-222. Oresmaa, L, Kotikoski, H, Haukka, M, Salminen, J, Oksala, O, Pohjala, E, Moilanen, E, Vapaatalo, H, Vainiotalo, P, Aulaskari, P 2005, 'Synthesis and ocular effects of imidazole nitrolic acids', Journal of Medicinal Chemistry, vol 48, pp. 4231-4236. Paajanen, L, Tuure, T, Vaarala, O, Korpela, R 2005, 'Homogenization of milk has no effect on milk-specific antibodies in healthy adults', Milchwissenschaft, vol 60, pp. 239-243. Paajanen, L, Korpela, R, Tuure, T, Honkanen, J, Järvelä, I, Ilonen, J, Knip, M, Vaarala, O, Kokkonen, J, Järvelä, I 2005, 'Cow milk is not responsible for most gastrointestinal immune-like syndromes: evidence from a population-based study', American Journal of Clinical Nutrition, vol 82, no. 6, pp. 1327-1335. Paajanen, L, Vaarala, O, Karttunen, R, Tuure, T, Korpela, R, Kokkonen, J 2005, 'Increased IFN-[gamma] secretion from duodenal biopsy samples in delayed-type cow's milk allergy', Pediatric Allergy and Immunology, vol 16, pp. 439-443. Seppo, L, Korpela, R, Lönnerdal, B, Metsäniitty, L, Juntunen-Backman, K, Klemola, T, Paganus, A, Vanto, T 2005, 'A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula (1-3)', American Journal of Clinical Nutrition, vol 82, no. 1, pp. 140-145. Seppo, L, Lähteenmäki, T, Tikkanen, MJ, Vanhanen, H, Korpela, R, Vapaatalo, H, Vanhanen, H 2005, 'Effects of vitamin E on the toxicity of oxidized LDL on endothelial cells in vitro in smokers vs nonsmokers on diets rich in fish', European Journal of Clinical Nutrition, vol 59, pp. 1282-1290. Veijola, L, Myllyluoma, E, Korpela, R, Rautelin, H, Beijola, L 2005, 'Stool antigen tests in the diagnosis of Helicobacter pylori infection before and after eradication therapy', World Journal of Gastroenterology, vol 11, pp. 7340-7344. Viljanen, M, Pohjavuori, E, Haahtela, T, Korpela, R, Kuitunen, M, Sarnesto, A, Vaarala, O, Savilahti, E 2005, 'Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome', Journal of Allergy and Clinical Immunology, vol 115, pp. 1254-1259. Viljanen, M, Kuitunen, M, Haahtela, T, Juntunen-Backman, K, Korpela, R, Savilahti, E 2005, 'Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants', Pediatric Allergy and Immunology, vol 16, pp. 65-71. Viljanen, M, Savilahti, E, Haahtela, T, Juntunen-Backman, K, Korpela, R, Poussa, T, Tuure, T, Kuitunen, M 2005, 'Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial', Allergy : European journal of allergy and clinical immunology, vol 60, no. 4, pp. 494-500. Väänänen, A, Kankuri, E, Rauhala, P 2005, 'Nitric oxide-related species-induced protein oxidation: reversible, irreversible, and protective effects on enzyme function of papain', Free Radical Biology & Medicine, vol 38, pp. 1102-1111.

2006 Asmawi, MZ, Seppo, L, Vapaatalo, H, Korpela, R 2006, 'Hypolactasia & lactose intolerance among three ethnic groups in Malaysia', Indian Journal of Medical Research , vol 124, pp. 697-704. Helske, S, Syväranta, S, Kupari, M, Lappalainen, J, Laine , M, Lommi, J, Turto, H, Mäyränpää, M, Werkkala, K, Kovanen, PT, Lindstedt, KA 2006, 'Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves', European Heart Journal, vol 27, pp. 1495-1504. Hongisto, S, Paajanen, L, Saxelin, M, Korpela, R 2006, 'A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation', European Journal of Clinical Nutrition, vol 60, pp. 319-324. Jauhiainen, T, Salo, P, Niittynen, L, Poussa, T, Korpela, R 2006, 'Effects of low-fat hard cheese enriched with plant stanol esters on serum lipids and apolipoprotein B in mildly hypercholesterolaemic subjects', European Journal of Clinical Nutrition, vol 60, pp. 1253- 1257.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Kajander, K, Korpela, R 2006, 'Clinical studies on alleviating the symptoms of irritable bowel syndrome with a probiotic combination', Asia Pacific Journal of Clinical Nutrition, vol 15, no. 4, pp. 576-580. Karppanen, H, Mervaala, E 2006, 'Sodium intake and hypertension', Progress in Cardiovascular Diseases, vol 49, no. 2, pp. 59-75. Lepäntalo, A, Mikkelson, J, Resendiz, J, Viiri, L, Backman, JT, Kankuri, E, Karhunen, P, Lassila, RPT 2006, 'Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients', Thrombosis and Haemostasis, vol 95, no. 2, pp. 253-259. Leskinen, MJ, Heikkilä, HM, Speer, MY, Hakala, JK, Laine , M, Kovanen, PT, Lindstedt, KA 2006, 'Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-[kappa]B-mediated survival signaling', Experimental Cell Research, vol 312, pp. 1289-1298. Louhelainen, M, Merasto, S, Finckenberg, P, Lapatto, R, Cheng, ZJ, Mervaala, E 2006, 'Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats', Journal of Hypertension, vol 24, pp. 947- 956. Malinen, M, Heikkinen, L, Harjula, A, Tilvis, R 2006, 'Yli 70-vuotiaiden sydänleikkaus palautti toimintakyvyn, mutta ulkopuolisen avun saanti lisääntyi', Yleislääkäri, vol 21, no. 5, pp. 25-29. Oresmaa, L, Kotikoski, H, Haukka, M, Oksala, O, Pohjala, E, Vapaatalo, H, Vainiotalo, P, Aulaskari, P 2006, 'Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters', Bioorganic & Medicinal Chemistry, vol 16, pp. 2144-2147. Oresmaa, L, Kotikoski, H, Haukka, M, Oksala, O, Pohjala, E, Vapaatalo, H, Moilanen, E, Vainiotalo, P, Aulaskari, P 2006, 'Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes', European Journal of Medicinal Chemistry, vol 41, no. 9, pp. 1073- 1079. Paajanen, L, Kokkonen, J, Karttunen, TJ, Tuure, T, Korpela, R, Vaarala, O 2006, 'Intestinal cytokine mRNA expression in delayed-type cow's milk allergy', Journal of Pediatric Gastroenterology and Nutrition, vol 43, pp. 470-476. Pilvi, T, Jauhiainen, T, Cheng, ZJ, Mervaala, E, Vapaatalo, H, Korpela, R 2006, 'Lupin protein attenuates the development of hypertension and normalises the vascular function of NaCl-loaded Goto-Kakizaki rats', Journal of Physiology and Pharmacology, vol 57, no. 2, pp. 167-176. Pitkäranta, A, Roivanen, M, Blomgren, K, Peltola, J, Kaijalainen, T, Räty, R, Ziegler, T, Rönkkö, E, Hatakka, K, Korpela, R, Poussa, T, Leinonen, M, Hovi, T 2006, 'Presence of viral and bacterial pathogens in the nasopharynx of otitis-prone children: a prospective study', International Journal of Pediatric Otorhinolaryngology, vol 70, no. 4, pp. 647-654. Pätilä, T, Ikonen, T, Rutanen, J, Ahonen, A, Lommi, J, Lappalainen, K, Krogerus, L, Ihlberg, L, Partanen, T, Lähteenoja, L, Virtanen, K, Alitalo, K, Ylä-Herttuala, S, Harjula, A 2006, 'Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia', Journal of Heart and Lung Transplantation, vol 25, no. 2, pp. 206-213. Siren, V, Salmenperä, P, Kankuri, E, Bizik, J, Sorsa, T, Tervahartiala, T, Vaheri, A 2006, 'Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases', Annals of Medicine, vol 38, pp. 212-220. Törmäkangas, L, Ketonen, J, Leinonen, M, Saikku, P, Paakkari, I 2006, 'Increased prostanoid dependency of arterial relaxation in Chlamydia pneumoniae-infected mice', Journal of Medical Microbiology, vol 55, pp. 1017-1021. Vendt, N, Grunberg, H, Tuure, T, Malminiemi, O, Wuolijoki, E, Tillmann, V, Sepp, E, Korpela, R 2006, 'Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial', Journal of Human Nutrition and Dietetics, vol 19, pp. 51-58. Väänänen, A, Salmenperä, P, Hukkanen, M, Rauhala, P, Kankuri, E 2006, 'Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages', Free Radical Biology & Medicine, vol 41, pp. 120-131.

2007 Bäcklund, T, Lakkisto, P, Palojoki, E, Grönholm, T, Saraste, A, Finckenberg, P, Mervaala, E, Tikkanen, I, Laine , M 2007, 'Activation of protective and damaging components of the cardiac renin-angiotensin system after myocardial infarction in experimental diabetes', Journal of the Renin-Angiotensin-Aldosterone System, vol 8, no. 2, pp. 66-73. Dugo, L, Collin, M, Allen, D, Patel, N, Bauer, I, Mervaala, E, Louhelainen, M, Foster, S, Yaqoob, M, Thiemermann, C 2007, 'Inhibiting glycogen synthase kinase 3beta in sepsis', Novartis Foundation symposium., vol 280, pp. 128-142. Hatakka, K, Ahola, AJ, Yli-Knuuttila, H, Richardson, M, Poussa, T, Meurman, JH, Korpela, R 2007, 'Probiotics reduce the prevalence of oral candida in the elderly: a randomized controlled trial', Journal of Dental Research, vol 86, no. 2, pp. 125-130. Hatakka, K, Blomgren, K, Pohjavuori, S, Kaijalainen, T, Poussa, T, Leinonen, M, Korpela, R, Pitkäranta, A 2007, 'Treatment of acute otitis media with probiotics in otitis-prone children: a double-blind, placebo-controlled randomised study', Clinical Nutrition, vol 26, no. 3, pp. 314-321. Helske, S, Laine , M, Kupari, M, Lommi, J, Turto, H, Nurmi, L, Tikkanen, I, Werkkala, K, Lindstedt, KA, Kovanen, PT 2007, 'Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves', European Heart Journal, vol 28, no. 15, pp. 1894-1903.

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RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Hiltunen, TP, Suonsyrjä, T, Hannila-Handelberg, T, Paavonen, KJ, Miettinen, HE, Strandberg, T, Tikkanen, I, Tilvis, R, Pentikäinen, PJ, Virolainen, J, Kontula, K 2007, 'Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, crossover study with four antihypertensive drugs (The GENRES Study)', American Journal of Hypertension, vol 20, pp. 311-318. Holma, R, Salmenperä, P, Virtanen, I, Vapaatalo, H, Korpela, R 2007, 'Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats', Journal of Physiology and Pharmacology, vol 58, no. 3, pp. 455-467. Ikonen, T, Pätilä, T, Virtanen, K, Lommi, JJ, Lappalainen, K, Kankuri, EM, Krogerus, L, Harjula, A 2007, 'Ligation of ameroid-stenosed coronary artery leads to reproducible myocardial infarction: a pilot study in a porcine model', Journal of Surgical Research, vol 142, no. 1, pp. 195-201. Jauhiainen, T, Rönnback, M, Vapaatalo, H, Wuolle, K, Kautiainen, H, Korpela, R 2007, 'Lactobacillus helveticus fermented milk reduces arterial stiffness in hypertensive subjects', International Dairy Journal, vol 17, pp. 1209-1211. Jauhiainen, T, Wuolle, K, Vapaatalo, H, Kerojoki, O, Nurmela, K, Lowrie, C, Korpela, R 2007, 'Oral absorption, tissue distribution and excretion of a radiolabelled analog of a milk-derived antihypertensive peptide, Ile-Pro-Pro, in rats', International Dairy Journal, vol 17, pp. 1216-1223. Kajander, K, Krogius-Kurikka, L, Rinttilä, T, Karjalainen, H, Palva, A, Korpela, R 2007, 'Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome', Alimentary Pharmacology & Therapeutics, vol 26, no. 3, pp. 463-473. Kekkonen, R, Vasankari, T, Vuorimaa, T, Haahtela, TMK, Julkunen, I, Korpela, R 2007, 'The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners', International Journal of Sport Nutrition & Exercise Metabolism, vol 17, pp. 352-363. Kekkonen, R, Ahlroos, T, Suomalainen, T, Tynkkynen, S, Poussa, T, Nevala, R, Korpela, R 2007, 'A combination of galacto- oligosaccharides and Lactobacillus GG increases bifidobacteria to a greater extent than Lactobacillus GG on its own', Milchwissenschaft, vol 62, no. 3, pp. 326-330. Kukkonen, K, Savilahti, E, Haahtela, T, Juntunen-Backman, K, Korpela, R, Poussa, T, Tuure, T, Kuitunen, M 2007, 'Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial', Journal of Allergy and Clinical Immunology, vol 119, no. 1, pp. 192-198. Lehto, JT, Halme, M, Tukiainen, P, Harjula, A, Sipponen, J, Lautenschlager, I 2007, 'Human herpesvirus-6 and -7 after lung and heart- lung transplantation', Journal of Heart and Lung Transplantation, vol 26, no. 1, pp. 41-47. Lilleberg, J, Laine , M, Palkama, T, Kivikko, M, Pohjanjousi, P, Kupari, M 2007, 'Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure', European Journal of Heart Failure, vol 9, pp. 75-82. Louhelainen, M, Vahtola, E, Kaheinen, P, Leskinen, H, Merasto, S, Kytö, V, Finckenberg, P, Colucci, W, Levijoki, J, Pollesello, P, Haikala, H, Mervaala, E 2007, 'Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats', British Journal of Pharmacology, vol 150, pp. 851-861. Moreira, A, Kekkonen, R, Korpela, R, Delgado, L, Haahtela, T 2007, 'Allergy in marathon runners and effect of Lactobacillus GG supplementation on allergic inflammatory markers', Respiratory Medicine, vol 101, no. 6, pp. 1123-1131. Myllyluoma, E, Ahlroos, T, Veijola, L, Rautelin, H, Tynkkynen, S, Korpela, R 2007, 'Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota', International Journal of Antimicrobial Agents, vol 29, pp. 66-72. Myllyluoma, E, Kajander, K, Mikkola, H, Kyrönpalo, S, Rasmussen, M, Kankuri, E, Sipponen, P, Vapaatalo, H, Korpela, R 2007, 'Probiotic intervention decreases serum gastrin-17 in Helicobacter pylori infection: alimentary tract', Digestive and Liver Disease, vol 39, pp. 516-523. Narva, M, Rissanen, J, Halleen, J, Vapaatalo, H, Väänänen, K, Korpela, R 2007, 'Effects of bioactive peptide, valyl-prolyl-proline (VPP), and Lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats', Annals of Nutrition and Metabolism, vol 51, pp. 65-74. Niittynen, L, Kajander, K, Korpela, R 2007, 'Galacto-oligosaccharides and bowel function', Scandinavian Journal of Food and Nutrition, vol 51, no. 2, pp. 62-66. Paavola, J, Viitasalo, M, Laitinen-Forsblom, PJ, Pasternack, M, Swan, H, Tikkanen, I, Toivonen, L, Kontula, K, Laine , M 2007, 'Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves', European Heart Journal, vol 28, pp. 1135-1142. Piirainen, L, Peuhkuri, K, Backstrom, K, Korpela, R, Salminen, S 2007, 'Prune juice has a mild laxative effect in adults with certain gastrointestinal symptoms', Nutrition Research, vol 27, no. 8, pp. 511-513. Pilvi, T, Korpela, R, Huttunen, M, Vapaatalo, H, Mervaala, E 2007, 'High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice', British Journal of Nutrition, vol 98, pp. 900-907. Poussa, H, Strandberg, T, Tikkanen, I, Kauhanen, P, Lepäntalo, M 2007, 'Diagnosis and treatment of dyslipidemia are neglected in patients with peripheral artery disease', Scandinavian Cardiovascular Journal, vol 41, no. 3, pp. 138-141.

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RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Repo, JM, Rantala, IS, Honkanen, TT, Mustonen, JT, Kööbi, P, Tahvanainen, AM, Niemelä, OJ, Tikkanen, I, Rysä, JM, Ruskoaho, HJ, Pörsti, IH 2007, 'Paricalcitol aggravates perivascular fibrosis in rats with renal insufficiency and low calcitriol', Kidney International, vol 72, pp. 977-984. Sairanen, U, Piirainen, L, Gråsten, S, Tompuri, T, Mättö, J, Saarela, M, Korpela, R 2007, 'The effect of probiotic fermented milk and inulin on the functions and microecology of the intestine', Journal of Dairy Research, vol 74, pp. 367-373. Sairanen, U, Piirainen, L, Nevala, R, Korpela, R 2007, 'Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects', European Journal of Clinical Nutrition, vol 61, pp. 1423-1428. Saukkonen, K, Lakkisto, P, Varpula, M, Varpula, T, Voipio-Pulkki, L, Pettilä, V, Pulkki, K 2007, 'Association of cell-free plasma DNA with hospital mortality and organ dysfunction in intensive care unit patients', Intensive Care Medicine, vol 33, no. 9, pp. 1624-1627. Seppo, L, Jauhiainen, T, Nevala, R, Poussa, T, Korpela, R 2007, 'Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol', European Journal of Nutrition, vol 46, pp. 111-117. Vento, AE, Hämmäinen, P, Pätilä, T, Kankuri, E, Harjula, A, Vento, A 2007, 'Somatic stem cell transplantation for the failing heart', Scandinavian Journal of Surgery, vol 96, no. 2, pp. 131-139. Österlund, P, Ruotsalainen, T, Korpela, R, Saxelin, M, Ollus, A, Valta, P, Kouri, M, Elomaa, I, Joensuu, H 2007, 'Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: randomised study', British Journal of Cancer, vol 97 (2007), no. 8, pp. 1028-1034.

2008 Arvela, E, Söderström, M, Albäck, A, Aho, P, Tikkanen, I, Lepäntalo, M 2008, 'Estimated glomerular filtration rate (eGFR) as a predictor of outcome after infrainguinal bypass in patients with critical limb ischemia', European Journal of Vascular and Endovascular Surgery, vol 36, no. 1, pp. 77-83. Babusikova, O, Zeleznikova, T, Kirschnerova, G, Kankuri, E 2008, 'Hematogones in acute leukemia during and after therapy', Leukemia and Lymphoma, vol 49, no. 10, pp. 1935-1944. Eräranta, A, Kurra, V, Tahvanainen, AM, Vehmas, T, Kööbi, P, Lakkisto, P, Tikkanen, I, Niemelä, O, Mustonen, J, Pörsti, I 2008, 'Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency', Journal of Hypertension, vol 26, no. 8, pp. 1661-1668. Hatakka, K, Mutanen, M, Holma, RM, Saxelin, M, Korpela, RA 2008, 'Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp shermanii JS administered in capsules is ineffective in lowering serum lipids', Journal of the American College of Nutrition, vol 27, no. 4, pp. 441-447. Hatakka, K, Holma, R, El-Nezami, H, Suomalainen, T, Kuisma, M, Saxelin, M, Poussa, T, Mykkänen, H, Korpela, R 2008, 'The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon', International Journal of Food Microbiology, vol 128, pp. 406-410. Kajander, K, Myllyluoma, E, Rajilic-Stojanovic, M, Kyrönpalo, S, Rasmussen, M, Järvenpää, S, Zoetendals, E, Vos de, WM, Vapaatalo, H, Korpela, R 2008, 'Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota', Alimentary Pharmacology & Therapeutics, vol 27, no. 1, pp. 48-57. Kankuri, E, Babusikova, O, Hlubinova, K, Salmenperä, P, Boccaccio, C, Lubitz, W, Harjula, A, Bizik, J 2008, 'Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells', International Journal of Cancer, vol 122, no. 6, pp. 1243-1252. Kekkonen, R, Lummela, N, Karjalainen, H, Latvala, S, Tynkkynen, S, Järvenpää, S, Kautiainen, H, Julkunen, I, Vapaatalo, H, Korpela, R 2008, 'Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults', World Journal of Gastroenterology, vol 14, no. 13, pp. 2029-2036. Kekkonen, R, Kajasto, E, Miettinen, M, Veckman, V, Korpela, R, Julkunen, I 2008, 'Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-[gamma] production', World Journal of Gastroenterology, vol 14, no. 8, pp. 1192-1203. Kekkonen, R, Sysi-Aho, M, Seppänen-Laakso, T, Julkunen, I, Vapaatalo, H, Oresic, M, Korpela, R 2008, 'Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults', World Journal of Gastroenterology, vol 14, no. 20, pp. 3188-3194. Ketonen, J, Mervaala, E 2008, 'Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low- density lipoprotein receptor-deficient mice on high-fat diet', Heart and Vessels, vol 23, pp. 420-429. Kukkonen, K, Savilahti, E, Haahtela, T, Juntunen-Backman, K, Korpela, R, Poussa, T, Tuure, T, Kuitunen, M 2008, 'Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial', Pediatrics (English Edition), vol 122, no. 1, pp. 8-12. Kylmälä, M, Antila, M, Kivistö, S, Lauerma, K, Vesterinen, P, Hänninen, HA, Toivonen, L, Laine , MK 2008, 'Tissue Doppler strain- mapping in the assessment of the extent of chronic myocardial infarction: validation using magnetic resonance imaging', European Journal of Echocardiography, vol 9, no. 5, pp. 678-684.

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CardioMed/Mervaala

Kärpänen, T, Bry, M, Ollila, H, Seppänen-Laakso, T, Liimatta, E, Leskinen, H, Kivelä, R, Helkamaa, T, Merentie, M, Jeltsch, M, Paavonen, K, Andersson, LC, Mervaala, E, Hassinen, I, Ylä-Herttuala, S, Oresic, M, Alitalo, K 2008, 'Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy', Circulation Research, vol 103, no. 9, pp. 1018-1026. Latvala, S, Pietilä, T, Veckman, V, Kekkonen, R, Tynkkynen, S, Korpela, R, Julkunen, I 2008, 'Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells', World Journal of Gastroenterology, vol 14, no. 36, pp. 5570-5583. Marschan, E, Kuitunen, M, Kukkonen, K, Poussa, T, Sarnesto, A, Haahtela, T, Korpela, R, Savilahti, E, Vaarala, O, Savilahti, E 2008, 'Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation', Clinical and Experimental Allergy, vol 38, no. 4, pp. 611-618. Mentula, S, Tuure, T, Koskenala, R, Korpela, R, Könönen, E 2008, 'Microbial composition and fecal fermentation end products from colicky infants: a probiotic supplementation pilot', Microbial Ecology in Health & Disease, vol 20, pp. 37-47. Myllyluoma, E, Ahonen, A, Korpela, R, Vapaatalo, H, Kankuri, E 2008, 'Effects of multispecies probiotic combination on Helicobacter pylori infection in vitro', Clinical and vaccine immunology., vol 15, no. 9, pp. 1472-1482. Niemi-Murola, L, Remes, V, Turunen, JP, Harjula, A, Helenius, I 2008, 'Valmistuvat lääketieteen opiskelijat vailla toimenpidetaitoja: [terveydenhuoltotutkimus]', Suomen lääkärilehti , vol vsk 63, no. 4, pp. 297-301. Niittynen, L, Jauhiainen, T, Poussa, T, Korpela, R 2008, 'Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet', International Journal of Food Sciences and Nutrition, vol 59, no. 5, pp. 357-367. Piirainen, L, Haahtela, S, Helin, T, Korpela, R, Haahtela, T, Vaarala, O 2008, 'Effect of Lactobacillus rhamnosus GG on rBet v1 and rMal d1 specific IgA in the saliva of patients with birch pollen allergy', Annals of Allergy, Asthma, & Immunology, vol 100, no. 4, pp. 338- 342. Piirainen, L, Kekkonen, R, Kajander, K, Ahlroos, T, Tynkkynen, S, Nevala, R, Korpela, R 2008, 'In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own', Annals of Nutrition and Metabolism, vol 52, pp. 204-208. Pilvi, T, Storvik, M, Louhelainen, M, Merasto, S, Korpela, R, Mervaala, E 2008, 'Effect of dietary calcium and dairy proteins on the adipose tissue gene expression profile in diet-induced obesity', Journal of Nutrigenetics and Nutrigenomics, vol 1, pp. 240-251. Pilvi, T, Seppänen-Laakso, T, Simolin, H, Finckenberg, P, Huotari, A, Herzig, K, Korpela, R, Oresic, M, Mervaala, E 2008, 'Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction', World Journal of Gastroenterology, vol 14, no. 28, pp. 4462-4472. Pätilä, T, Jokinen, JJ, Salminen, J, Kankuri, E, Harjula, A, Jokinen, J, Harjula, ALJ 2008, 'Polyglycolic acid glue does not prevent intrapericardial adhesions in a short-term follow-up', Journal of Surgical Research, vol 148, no. 2, pp. 181-184. Räsänen, JV, Sihvo, E, Rantanen, T, Ahotupa, M, Färkkilä, M, Harjula, A, Salo, J, Räsänen, J 2008, 'Gastroesophageal reflux patients' defective antioxidative capacity in the proximal esophageal mucosa before antireflux surgery and also after 4-year follow-up', Annals of Medicine, vol 40, no. 1, pp. 74-80. Salmenperä, P, Kankuri, E, Bizik, J, Siren, V, Virtanen, I, Takahashi, S, Leiss, M, Fässler, R, Vaheri, A 2008, 'Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction', Experimental Cell Research, vol 314, pp. 3444-3452. Saukkonen, K, Lakkisto, P, Pettilä, V, Varpula, M, Karlsson, S, Ruokonen, E, Pulkki, K, The Finnsepsis study group 2008, 'Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock', Clinical Chemistry (Washington, DC), vol 54, no. 6, pp. 1000-1007. Seppo, L, Tuure, T, Korpela, R, Järvelä, I, Rasinperä, H, Sahi, T 2008, 'Can primary hypolactasia manifest itself after the age of 20 years?: a two-decade follow-up study', Scandinavian Journal of Gastroenterology, vol 43, no. 9, pp. 1082-1087. Seppänen, S, Niittynen, L, Poussa, T, Korpela, R 2008, 'Removing lactose from milk does not delay bowel function or harden stool consistency in lactose-tolerant women', European Journal of Clinical Nutrition, vol 62, pp. 727-732. Suonsyrjä, T, Hannila-Handelberg, T, Paavonen, KJ, Miettinen, HE, Donner, K, Strandberg, T, Tikkanen, I, Tilvis, R, Pentikäinen, PJ, Kontula, K, Hiltunen, TP 2008, 'Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES study', Journal of Hypertension, vol 26, pp. 1250-1256. Tikkanen, I 2008, 'Kohonneen verenpaineen lääkehoito kehittyy: [lääketieteellinen pääkirjoitus]', Suomen lääkärilehti , vol 63, pp. 144. Vaajanen, A, Mervaala, E, Oksala, O, Vapaatalo, H 2008, 'Is there a relationship between blood pressure and intraocular pressure?: an experimental study in hypertensive rats', Current Eye Research, vol 33, pp. 325-332. Vaajanen, A, Vapaatalo, H, Kautiainen, H, Oksala, O 2008, 'Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye', Investigative Ophthalmology & Visual Science, vol 49, no. 6, pp. 2557-2562.

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CardioMed/Mervaala

Vaajanen, A, Luhtala, S, Oksala, O, Vapaatalo, H 2008, 'Does the renin-angiotensin system also regulate intra-ocular pressure?', Annals of Medicine, vol 40, pp. 418-427. Vahtola, E, Louhelainen, M, Merasto, S, Martonen, E, Penttinen, S, Aahos, I, Kytö, V, Virtanen, I, Mervaala, E 2008, 'Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat', Journal of Hypertension, vol 26, pp. 334-344. Väänänen, A, Salmenperä, P, Hukkanen, M, Miranda, K, Harjula, A, Rauhala, P, Kankuri, E 2008, 'Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide', Free Radical Biology & Medicine, vol 45, no. 6, pp. 749-755.

2009 Donner, K, Hiltunen, TP, Suonsyrjä, T, Hannila-Handelberg, T, Tikkanen, I, Antikainen, M, Hirvonen, A, Kontula, K 2009, 'CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men', Journal of Hypertension, vol 27, pp. 2001-2009. Ehlers, P, Hakala, A, Turpeinen, AM, Korpela, R, Vapaatalo, H 2009, 'Casein-derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro attenuate the development of hypertension and improve endothelial function in salt-loaded Goto-Kakizaki rats', Journal of functional foods, vol 1, no. 4, pp. 366-374. Enzerink, A, Salmenperä, P, Kankuri, E, Vaheri, A 2009, 'Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration', Molecular Immunology, vol 46, pp. 1787-1795. Eriksson, H, Jalonen, J, Heikkinen, L, Kivikko, M, Laine , M, Leino, K, Kuitunen, A, Kuttila, K, Peräkylä, T, Sarapohja, T, Suojaranta- Ylinen, R, Valtonen, M, Salmenperä, M 2009, 'Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function', Annals of Thoracic Surgery, vol 87, no. 2, pp. 448-454. Hatakka, K, Piirainen, L, Pohjavuori, S, Poussa, T, Savilahti, E, Korpela, R 2009, 'Allergy in day care children: prevalence and environmental risk factors', Acta Paediatrica, vol 98, no. 5, pp. 817-822. Jauhiainen, T, Kautiainen, H, Vapaatalo, H 2009, 'Maidon peptideistä on hyötyä verenpaineen hallinnassa', Suomen lääkärilehti , vol 64, no. 15-16, pp. 1453-1457. Jauhiainen, T, Korpela, R, Vapaatalo, H, Turpeinen, A, Kautiainen, H 2009, 'Bioactive milk peptides and blood pressure', Agro food industry hi-tech., vol 20, no. 2, pp. 26-28. Jäkälä, P, Pere, E, Lehtinen, R, Turpeinen, A, Korpela, R, Vapaatalo, H 2009, 'Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats', Journal of Physiology and Pharmacology, vol 60, no. 4, pp. 11-20. Jäkälä, P, Jauhiainen, T, Korpela, R, Vapaatalo, H 2009, 'Milk-protein derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro protect endothelial function in vitro in hypertensive rats', Journal of functional foods, vol 1, no. 3, pp. 266-273. Kajander, K, Myllyluoma, E, Kyrönpalo, S, Rasmussen, M, Sipponen, P, Mattila, I, Seppänen-Laakso, T, Vapaatalo, H, Oresic, M, Korpela, R 2009, 'Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome', World Journal of Gastroenterology, vol 15, no. 48, pp. 6068-6074. Kankainen, M, Paulin, L, Tynkkynen, S, von Ossowski, I, Reunanen, J, Partanen, P, Satokari, R, Vesterlund, S, Hendrickx, APA, Lebeer, S, Keersmaecker, SCJD, Vanderleyden, J, Hämäläinen, T, Laukkanen, S, Salovuori, N, Ritari, J, Alatalo, E, Korpela, R, Mattila- Sandholm, T, Lassig, A, Hatakka, K, Kinnunen, KT, Karjalainen, H, Saxelin, M, Laakso, K, Surakka, A, Palva, A, Salusjärvi, T, Auvinen, P, Vos de, WM 2009, 'Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein', Proceedings of the National Academy of Sciences of the United States of America, vol 106, no. 40, pp. 17193-17198. Kuitunen, M, Kukkonen, K, Juntunen-Backman, K, Korpela, R, Poussa, T, Tuure, T, Haahtela, T, Savilahti, E 2009, 'Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort', Journal of Allergy and Clinical Immunology, vol 123, no. 2, pp. 335-341. Lakkisto, P, Csonka, C, Fodor, G, Bencsik, P, Voipio-Pulkki, L, Ferdinandy, P, Pulkki, K 2009, 'The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43', Scandinavian Journal of Clinical & Laboratory Investigation, vol 69, no. 2, pp. 209-218. Lehto, M, Jurkko, R, Parikka, H, Mäntynen, V, Väänänen, H, Montonen, J, Voipio-Pulkki, L, Toivonen, L, Laine , M 2009, 'Reversal of atrial remodeling after cardioversion of persistent atrial fibrillation measured with magnetocardiography', Pacing and Clinical Electrophysiology, vol 32, no. 2, pp. 217-223. Louhelainen, M, Vahtola, E, Forsten, H, Merasto, S, Kytö, V, Finckenberg, P, Leskinen, H, Kaheinen, P, Tikkanen, I, Levijoki, J, Mervaala, E 2009, 'Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats', Journal of Hypertension, vol 27, pp. 2094-2107. Louhelainen, M, Merasto, S, Finckenberg, P, Vahtola, E, Kaheinen, P, Leskinen, H, Levijoki, J, Pollesello, P, Haikala, H, Mervaala, EMA 2009, 'Effects of calcium sensitizer OR-1986 on cardiovascular mortality and myocardial remodelling in hypertensive Dahl/Rapp rats', Journal of Physiology and Pharmacology, vol 60, pp. 41-47.

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CardioMed/Mervaala

Luhtala, S, Vaajanen, A, Oksala, O, Valjakka, J, Vapaatalo, H 2009, 'Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues', Journal of Ocular Pharmacology and Therapeutics, vol 25, no. 1, pp. 23- 28. Lummela, N, Kekkonen, R, Jauhiainen, T, Pilvi, T, Tuure, T, Järvenpää, S, Eriksson, JG, Korpela, R 2009, 'Effects of a fibre-enriched milk drink on insulin and glucose levels in healthy subjects', Nutrition Journal, vol 8, pp. 45. Paatela, H, Mervaala, E, Deb, S, Wähälä, K, Tikkanen, MJ 2009, 'HDL-associated dehydroepiandrosterone fatty acyl esters: enhancement of vasodilatory effect of HDL', Steroids, vol 74, no. 10-11, pp. 814-818. Park, J, Mervaala, E, Muller, D, Menne, J, Fiebeler, A, Luft, F, Haller, H 2009, 'Rosuvastatin protects against angiotensin II-induced renal injury in a dose-dependent fashion', Journal of Hypertension, vol 27, pp. 599-605. Patila, T, Ikonen, T, Kankuri, E, Ahonen, A, Krogerus, L, Lauerma, K, Harjula, A 2009, 'Spontaneous recovery of myocardial function after ligation of Ameroid-stenosed coronary artery', Scandinavian Cardiovascular Journal, vol 43, no. 6, pp. 408-416. Peura, M, Bizik, J, Salmenperä, P, Noro, A, Korhonen, M, Pätilä, T, Vento, A, Vaheri, A, Alitalo, R, Vuola, J, Harjula, A, Kankuri, E 2009, 'Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing the HGF/c-Met/PI3K pathway', Wound Repair and Regeneration, vol 17, no. 4, pp. 569-577. Pilvi, T, Harala, S, Korpela, R, Mervaala, E 2009, 'Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice', British Journal of Nutrition, vol 102, pp. 337-341. Pätilä, T, Sihvo, EI, Räsänen, JV, Ramstad, R, Harjula, A, Salo, JA, Sihvo, E, Räsänen, J, Salo, J 2009, 'Paralysis of the upper rectus abdominis muscle after video-assisted or open thoracic surgery: an underdiagnosed complication?', Annals of Thoracic Surgery, vol 88, no. 4, pp. 1335-1337. Pätilä, T, Ikonen, T, Kankuri, E, Uutela, A, Lommi, J, Krogerus, L, Salmenperä, P, Bizik, J, Lauerma, K, Harjula, A 2009, 'Improved diastolic function after myoblast transplantation in a model of ischemia-infarction', Scandinavian Cardiovascular Journal, vol 43, no. 2, pp. 100-109. Sanchez-Nino, MD, Sanz, AB, Ihalmo, P, Lassila, M, Holthofer, H, Mezzano, S, Aros, C, Groop, P, Saleem, MA, Mathieson, PW, Langham, R, Kretzler, M, Nair, V, Lemley, KV, Nelson, RG, Mervaala, E, Mattinzoli, D, Rastaldi, MP, Ruiz-Ortega, M, Martin-Ventura, JL, Egido, J, Ortiz, A 2009, 'The MIF receptor CD74 in diabetic podocyte injury', Journal of the American Society of Nephrology, vol 20, no. 2, pp. 353-362. Surakka, A, Kajander, K, Rajilic-Stojanovic, M, Karjalainen, H, Hatakka, K, Vapaatalo, H, Zoetendal, E, Vos de, WM, Korpela, R, Tynkkynen, S 2009, 'Yoghurt containing galactooligosaccharides facilitates defecation among elderly subjects and selectively increases the number of bifidobacteria', International Journal of Probiotics & Prebiotics, vol 4, no. 1, pp. 65-74. Tikkanen, I, Lakkisto, P, Segersvärd, H, Siren, J, Forsten, H, Palojoki, E, Laine, M 2009, 'Hjärtats stamceller och regeneration vid hjärtskada', Finska Läkaresällskapets Handlingar, vol 169, no. 2, pp. 30-35. Turpeinen, AM, Kumpu, M, Ronnback, M, Seppo, L, Kautiainen, H, Jauhiainen, T, Vapaatalo, H, Korpela, R 2009, 'Antihypertensive and cholesterol-lowering effects of a spread containing bioactive peptides IPP and VPP and plant sterols', Journal of functional foods, vol 1, pp. 260-265. Turpeinen, A, Jauhiainen, T, Jäkälä, P, Lehtinen, R, Vapaatalo, H, Korpela, R 2009, 'Milk peptides and cardiovascular health: effects on blood pressure and beyond', Australian Journal of Dairy Technology, vol 64, no. 1, pp. 33-35. Volotinen, M, Mäenpää, J, Kautiainen, H, Tolonen, A, Uusitalo, J, Ropo, A, Vapaatalo, H, Aine, E 2009, 'Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor', European Journal of Pharmaceutical Sciences, vol 36, pp. 292-296. Volotinen, M, Mäenpää, J, Kankuri, E, Oksala, O, Pelkonen, O, Nakajima, M, Yokoi, T, Hakkola, J 2009, 'Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD', Investigative Ophthalmology & Visual Science, vol 50, no. 7, pp. 3099-3105.

2010 Ahola, AJ, Uusl-Rauva, J, Tossavainen, O, Lounatmaa, K, Gronberg, L, Piirainen, L, Poussa, T, Meurman, JH, Korpela, R 2010, 'Modifying the erosive potential of apple juice with milk constitutes', Milchwissenschaft, vol 65, no. 4, pp. 418-421. Augustin, MM, Salmenperä, P, Harjula, A, Kankuri, EM 2010, 'Heat Shock Enhances Troponin Expression and Decreases Differentiation-Associated Caspase-3 Dependence in Myoblasts Under Hypoxia', Journal of Surgical Research, vol 161, no. 1, pp. 62- 68. Biala, A, Martonen, E, Kaheinen, P, Levijoki, J, Finckenberg, P, Merasto, S, Louhelainen, M, Muller, DN, Luft, FC, Mervaala, E 2010, 'Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure', Hypertension Research, vol 33, pp. 1004-1011. Biala, A, Tauriainen, E, Siltanen, A, Shi, J, Merasto, S, Louhelainen, M, Martonen, E, Finckenberg, P, Muller, DN, Mervaala, E 2010, 'Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes', Blood Pressure, vol 19, pp. 196-205.

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RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Bry, M, Kivelä, R, Holopainen, T, Anisimov, A, Tammela, T, Soronen, J, Silvola, J, Saraste, A, Jeltsch, M, Korpisalo, P, Carmeliet, P, Lemström, KB, Shibuya, M, Yla-Herttuala, S, Alhonen, L, Mervaala, E, Andersson, LC, Knuuti, J, Alitalo, K 2010, 'Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation', Circulation (Baltimore), vol 122, no. 17, pp. 1725-1733. Eriksson, M, Lemström, KB, Suojaranta-Ylinen, RT, Martelius, T, Harjula, A, Sipponen, J, Halme, M, Piilonen, A, Salmenkivi, KM, Anttila, VA, Hämmäinen , P 2010, 'Control of Early Aspergillus Mortality After Lung Transplantation: Outcome and Risk Factors ', Transplantation Proceedings, vol 42, no. 10, pp. 4459-4464. Finckenberg, P, Mervaala, E 2010, 'Novel regulators and drug targets of cardiac hypertrophy', Journal of Hypertension, vol 28, pp. 33- 38. Hannila-Handelberg, T, Kontula, KK, Paukku, K, Lehtonen, JY, Virtamo, J, Tikkanen, I, Hiltunen, TP 2010, 'Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension', Journal of Hypertension, vol 28, no. 4, pp. 771-779. Hatakka, K, Piirainen, L, Pohjavuori, S, Poussa, T, Savilahti, E, Korpela, R 2010, 'Factors associated with acute respiratory illness in day care children', Scandinavian Journal of Infectious Diseases, vol 42, pp. 704-711. Holma, R, Hongisto, S, Saxelin, M, Korpela, R 2010, 'Constipation Is Relieved More by Rye Bread Than W heat Bread or Laxatives without Increased Adverse Gastrointestinal Effects', Journal of Nutrition, vol 140, pp. 534-541. Jauhiainen, T, Pilvi, TK, Cheng, ZJ, kautiainen, H, muller, D, Vapaatalo, H, Korpela, RA, Mervaala, E 2010, 'Milk products containing bioactive tripeptides have an antihypertensive effect in double transgenic rats (dTGR)', Journal of Nutrition and Metabolism. Jauhiainen, T, Ronnback, M, Vapaatalo, H, Wuolle, K, Kautiainen, H, Groop, P, Korpela, R 2010, 'Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects', European Journal of Clinical Nutrition, vol 64, pp. 424-431. Jokinen , JJ, Hämmäinen , P, Lemström, KB, Lommi, J, Sipponen, J, Harjula, ALJ 2010, 'Association between gastrointestinal symptoms and health-related quality of life after heart transplantation', Journal of Heart and Lung Transplantation, vol 29, no. 12, pp. 1388-1394. Jäkälä, P, Turpeinen, A, Rajakari, K, Korpela, RA, Vapaatalo, H 2010, 'Biological effects of casein-derived tripeptide powders are not affected by fermentation process', International Dairy Journal, vol 20, no. 5, pp. 366-370. Ketonen, J, Pilvi, T, Mervaala, E 2010, 'Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice', Heart and Vessels, vol 25, pp. 254-262. Ketonen, J, Shi, J, Martonen, E, Mervaala, E 2010, 'Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57BI/6 Mice', Circulation Journal, vol 74, no. 7, pp. 1479-1487. Kitabayashi, K, Siltanen, A, Patila, T, Mahar, MAA, Tikkanen, I, Koponen, J, Ono, M, Sawa, Y, Kankuri, E, Harjula, A 2010, 'Bcl-2 Expression Enhances Myoblast Sheet Transplantation Therapy for Acute Myocardial Infarction', Cell Transplantation, vol 19, no. 5, pp. 573-588. Korpela, RA, von Wright, A, Räty, K, Holma, RM, Tuure, T, Mykkänen, H 2010, 'The effect of rye bread and Lactobacillus GG fermented whey drink on fecal and urinary mutagenicity and fecal enzyme activities', International Journal of Probiotics & Prebiotics, vol 2010 / 5, no. 3, pp. 125-32. Kukkonen, K, Kuitunen, M, Haahtela, T, Korpela, R, Poussa, T, Savilahti, E 2010, 'High intestinal IgA associates with reduced risk of IgE-associated allergic diseases', Pediatric Allergy and Immunology, vol 21, no. 1, pp. 67-73. Lakkisto, P, Kyto, V, Forsten, H, Siren, J, Segersvard, H, Voipio-Pulkki, L, Laine , M, Pulkki, K, Tikkanen, I 2010, 'Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1 alpha, SDF-1 alpha and VEGF-B', European Journal of Pharmacology, vol 635, pp. 156-164. Lehtinen, R, Jauhiainen, T, Kankuri, E, Lindstedt, K, Kovanen, PT, Kerojoki, O, Korpela, R, Vapaatalo, H 2010, 'Effects of milk casein- derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vaso active precursors in vitro', Arzneimittel- Forschung, vol 60, pp. 182-185. Louhelainen, M, Merasto, S, Finckenberg, P, Vahtola, E, Kaheinen, P, Levijoki, J, Mervaala, E 2010, 'Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats', British Journal of Pharmacology, vol 160, pp. 142-152. Lyra, A, Krogius-Kurikka, L, Nikkila, J, Malinen, E, Kajander, K, Kurikka, K, Korpela, RA, Palva, A 2010, 'Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes', BMC Gastroenterology, vol 10, no. art. 110. Peura, M, Siltanen, A, Saarinen, I, Soots, A, Bizik, J, Vuola, J, Harjula, A, Kankuri, E 2010, 'Paracrine factors from fibroblast aggregates in a fibrin-matrix carrier enhance keratinocyte viability and migration', Journal of Biomedical Materials Research. Part A, vol 95A, no. 2, pp. 658-664.

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RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Pohjavuori, S, Ahola, A, Yli-Knuuttila, H, Piirainen, L, Poussa, T, Meurman, J, Korpela, RA 2010, 'Effect of consumption of Lactobacillus rhamnosus GG and calcium, in carrot-pineapple juice on dental caries risk in children', International Journal of Probiotics & Prebiotics, vol 5, no. 4, pp. 221-228. Saukkonen, K, Lakkisto, P, Kaunisto, MA, Varpula, M, Voipio-Pulkki, L, Varpula, T, Pettila, V, Pulkki, K 2010, 'HEME OXYGENASE 1 POLYMORPHISMS AND PLASMA CONCENTRATIONS IN CRITICALLY ILL PATIENTS', Shock (Philadelphia), vol 34, no. 6, pp. 558- 564. Saxelin, M, Tynkkynen, S, Salusjärvi, T, Kajander, K, Myllyluoma, E, Mattila-Sandholm, T, Korpela, RA 2010, 'Developing a multispecies probiotic combination', International Journal of Probiotics & Prebiotics, vol 5, no. 4, pp. 169-182. Saxelin, M, Lassig, A, Karjalainen, H, Tynkkynen, S, Surakka, A, Vapaatalo, H, Jarvenpaa, S, Korpela, R, Mutanen, M, Hatakka, K 2010, 'Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese', International Journal of Food Microbiology, vol 144, no. 2, pp. 293-300. Syvaranta, S, Helske, S, Laine , M, Lappalainen, J, Kupari, M, Mayranpaa, MI, Lindstedt, KA, Kovanen, PT 2010, 'Vascular Endothelial Growth Factor-Secreting Mast Cells and Myofibroblasts A Novel Self-Perpetuating Angiogenic Pathway in Aortic Valve Stenosis', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 30, pp. 1220-U329. Vaajanen, A, Lakkisto, P, Virtanen, I, Kankuri, E, Oksala, O, Vapaatalo, H, Tikkanen, I 2010, 'Angiotensin receptors in the eyes of arterial hypertensive rats', Acta Ophthalmologica, vol 88, no. 4, pp. 431-438. Vahtola, E, Louhelainen, M, Forsten, H, Merasto, S, Raivio, J, Kaheinen, P, Kyto, V, Tikkanen, I, Levijoki, J, Mervaala, E 2010, 'Sirtuin1- p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat', Cardiovascular Diabetology, vol 9.

A2 Review in scientific journal

2005 Korpela, R, Saxelin, M 2005, 'Functional dairy products - the Nordic perspective', Australian Journal of Dairy Technology, vol 60, pp. 170-172.

2007 Back, J, Kankuri, E, Ikonen, T, Pätilä, T, Sinisalo, J, Laine, M, Vapaatalo, H, Koponen, J, Hukkanen, M, Ylä-Herttuala, S, Alitalo, R, Kupari, M, Harjula, A 2007, 'Solusiirrot sydämen vajaatoiminnan hoidossa: [katsaus]', Duodecim, vol 123, no. 4, pp. 398-405. Jauhiainen, T, Korpela, R 2007, 'Milk peptides and blood pressure', Journal of Nutrition, vol 137, pp. 825S-829S. Moreira, A, Kekkonen, R, Delgado, L, Fonseca, J, Korpela, R, Haahtela, T 2007, 'Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis', European Journal of Clinical Nutrition, vol 61, pp. 443-460.

2008 Jokinen, JJ, Kukkonen, S, Hämmäinen, P, Lommi, J, Kupari, M, Harjula, A, Sipponen, J, Lemström, KB 2008, 'Aikuisten sydämensiirrot Suomessa: onko määrää syytä lisätä? : katsaus', Duodecim, vol 124, pp. 1953-1961.

2010 Jula, A, Kantola, I, Lehto, S, Mervaala, E, Metsärinne, K, Pörsti, I, Strandberg, T, Tikkanen, I, Tikkanen, T, Kukkonen-Harjula, K 2010, 'Kohonnut verenpaine: Käypä hoito -suosituksen päivitystiivistelmä', Duodecim, vol 126, pp. 673-674. Jäkälä, P, Vapaatalo, H 2010, 'Antihypertensive peptides from milk proteins', Pharmaceuticals, no. 3, pp. 251-272. Peuhkuri, K, Vapaatalo, H, Korpela, R 2010, 'Even low-grade inflammation impacts on small intestinal function', World Journal of Gastroenterology, vol 16, no. 9, pp. 1057-1062. Tikkanen, I 2010, 'Minkä valitsen ensimmäiseksi verenpainelääkkeeksi?', Duodecim, vol 126, pp. 891-896. Vapaatalo, H, Kotikoski, H, Oksala, O 2010, 'Role of nitric oxide in the regulation of intraocular pressure: a possibility for glaucoma treatment', Expert review of ophthalmology., vol 5, no. 6, pp. 751-758.

A3 Contribution to book/other compilations (refereed)

2005 Pilvi, T, Jauhiainen, T, Cheng, ZJ, Mervaala, E, Vapaatalo, H, Korpela, R 2005, 'Cardiovascular effects of lupin protein in two hypertensive animal models', Optimised processes for preparing healthy and added value food ingredients from lupin kernels, the European protein-rich grain legume, Aracne, Roma, pp. 159-168.

2008 11

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Harjula, A 2008, 'Kirurgian erikoislääkärikoulutus', Huippuosaajien yhteisö. [toimituskunta: Reijo Haapiainen ... et al.] ; [kuvat: Jukka Alstela ... et al.]., HYKS, operatiivinen tulosyksikkö, [Helsinki], pp. 264-268. Tikkanen, I, Tikkanen, T 2008, 'Sekundaariset hypertensiot', in /PJHMK;TJA.[A (ed.), Kardiologia, Duodecim, Helsinki, pp. 1062- 1070.

2009 Saxelin, M, Kajander, K, Korpela, RA 2009, 'LGG Extra, A multispecies Probiotic Combination: LGG Extra, A multispecies Probiotic Combination.', handbook of Probiotics and Prebiotics, 2nd edn, Hoboken.

A4 Article in conference publication (refereed)

2005 Helske, S, Aalto, S, Kupari, M, Lappalainen, J, Laine, M, Lommi, J, Kovanen, PT, Lindstedt, KA 2005, A role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves,, European Heart Journal 26 OXFORD UNIVERSITY PRESS.

2006 Helske, S, Laine, M, Kupari, M, Lommi, J, Tikkanen, I, Werkkala, K, Lindstedt, K, Kovanen, P 2006, Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves,, Circulation Research 114 LIPPINCOTT WILLIAMS & WILKINS. Ljungberg, M, Korpela, R, Ilonen, J, Ludvigsson, J, Vaapala, O 2006, 'Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type 1 diabetes- the PRODIA study', in IMMUNOLOGY OF DIABETES IV : PROGRESS IN OUR UNDERSTANDING , pp. 360-364 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES , vol. 1079.

2008 Mäenpää, J, Kotikoski, H, Aine, E, Alajuuma, P, Oksala, O, Vapaatalo, H 2008, 'Nitric oxide (NO) in the regulation of intraocular pressure', in Proceedings of the 7th international symposium on ocular pharmacology & therapeutics (ISOPT), pp. 61-64.

2009 Lakkisto, P, Siren, J, Immonen, K, Forsten, H, Kyto, V, Segersvard, H, Voipio-Pulkki, L, Laine, M, Pulkki, K, Tikkanen, I 2009, Carbon Monoxide Promotes Neovascularization After Myocardial Infarction by Modulating the Expression of Angiogenic Cytokines and Growth Factors,, Circulation Research 120 LIPPINCOTT WILLIAMS & WILKINS.

2010 Mervaala, E, Biala, A, Merasto, S, Lempiainen, J, Mattila, I, Martonen, EE, Eriksson, O, Louhelainen, M, Finckenberg, P, Kaheinen, P, Muller, DN, Luft, FC, Lapatto, R, Oresic, M 2010, Metabolomics in Angiotensin II-Induced Cardiac Hypertrophy,, Paper presented at 63rd Annual Fall Conference and Scientific Sessions of the American-Heart-Association-Council-for-High-Blood-Pressure- Research, Chicago, IL, SEP 23-26, 2009. Hypertension 55 2 LIPPINCOTT WILLIAMS & WILKINS.

B1 Unrefereed journal article

2005 Tikkanen, I 2005, 'Onko uusi verenpainelääke hintansa arvoinen?: [pääkirjoitus]', Suomen lääkärilehti , vol 60, no. 43, pp. 4355. Vapaatalo, H 2005, 'Januskasvoinen ASA: tulevaisuudenkin lääke [katsausartikkeli]', Suomen lääkärilehti , vol 60, no. 9, pp. 1027- 1031. Vapaatalo, H, Korpela, R, Jauhiainen, T 2005, 'Letter to the editor: response to Dr. Mizushima', American Journal of Hypertension, vol 18, pp. 1015.

2006 Kukkonen, K, Savilahti, E, Haahtela, T, Juntunen-Backman, K, Korpela, R, Poussa, T, Tuure, T, Kuitunen, M 2006, 'Pre- ja probiootit ehkäisevät atooppisen ekseeman puhkeamista: [referaatti J Allergy Clin Immunol -lehden artikkelista]', Duodecim, vol 122, no. 24, pp. 2959-2960. Kälviäinen, R, Autti-Rämö, I, Eriksson, K, Häppölä, O, Keränen, T, Kuoppala, J, Kurola, J, Kuusela, A, Mervaala, E, Salmi, T, Tallgren, M 2006, 'Pitkittynyt epileptinen kohtaus: [Käypä hoito -suosituksen tiivistelmä]', Duodecim, vol 122, pp. 473-475. Mervaala, E 2006, 'Aspiriiniresistenssi', TABU : lääkeinformaatiota Lääkelaitokselta, vol 14 , no. 6, pp. 9-10.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Paajanen, L, Korpela, R, Tuure, T, Honkanen, J, Järvelä, I, Ilonen, J, Knip, M, Vaarala, O, Kokkonen, J 2006, 'Lehmänmaito ei ole syynä useimpiin puolustusvasteen välittämiin ruoansulatuskanavan oireisiin - näyttö väestötutkimuksesta: [referaatti Am j clin nutr - lehden artikkelista]', Duodecim, vol 122, pp. 263-264. Tikkanen, I 2006, 'Pitäisikö prehypertensiota hoitaa?: [lääketieteellinen pääkirjoitus]', Suomen lääkärilehti , vol 61, pp. 4811.

2007 Harjula, A, Hämmäinen, P, Vento, A 2007, 'Modern surgical techniques of the failing heart: [editorial]', Scandinavian Journal of Surgery, vol 96, no. 2, pp. 94-95. Järvinen, M, Höckerstedt, K, Alhava, E, Juvonen, T, Puolakkainen, P, Aarnio, P, Kivilaakso, E, Eskelinen, M, Lepäntalo, M, Rintala, R, Kröger, H, Jalovaara, P, Ruutu, M, Kiviranta, I, Tammela, T, Tarkka, M, Aro, H, Serlo, W, Mäkelä, J, Harjula, A 2007, 'Kirurgian professorit: selvityshenkilöiltä varsin radikaaleja ehdotuksia erikoislääkärikoulutuksesta', Suomen lääkärilehti , vol vsk 62, no. 41, pp. 3777-3779. Kajander, K, Latti, M, Hatakka, K, Korpela, R 2007, 'An electronic diary versus a paper diary in measuring gastrointestinal symptoms', Digestive and Liver Disease, vol 39, pp. 288-289. Vapaatalo, H, Viinikka, L 2007, 'Suomalainen sauna: terveytemme turva vai turma? [pääkirjoitus]', Duodecim, vol 123, pp. 1538-1539.

2008 Kajander, K, Vapaatalo, H, Korpela, R 2008, 'Probiotics and the irritable bowel syndrome: authors' reply [letter]', Alimentary Pharmacology & Therapeutics, vol 27, pp. 617-618.

2009 Eräranta, A, Lakkisto, P, Tikkanen, I, Mustonen, J, Pörsti, I 2009, 'Paricalcitol and renin-angiotensin components in remnant kidneys: [letter to the editor]', Kidney International, vol 75, no. 3, pp. 339-340. Harjula, A, Vento, A, Hämmäinen, P, Pätilä, T, Kankuri, E 2009, 'Onko xenosta ja kantasoluista haastajaksi?', Sydänääni : Suomen kardiologisen seuran lehti., vol 20, no. 3A, pp. 50-56. Hämmäinen, P, Jokinen, JJ, Yesil, C, Hellstedt, M, Harjula, A 2009, 'Millainen elämänlaatu?', Sydänääni : Suomen kardiologisen seuran lehti., vol 20, no. 3A, pp. 41-45. Vaajanen, A, Vapaatalo, H 2009, 'Sääteleekö reniini-angiotensiinijärjestelmä silmänkin painetta?: [pääkirjoitus]', Duodecim, vol 125, no. 18, pp. 1931-1933.

2010 Vapaatalo, H, Mervaala, E 2010, 'Endoteelin typpioksidin löytäjä on poissa: mihin havainto on johtanut kolmessa vuosikymmenessä?', Duodecim, vol 126, no. 5, pp. 577-578.

C2 Edited book, compilation, conference proceeding or special issue of journal

2006 Aarnio, P, Airaksinen, J, Armstrong, E, Harjula, A, Juntunen, J, Juvonen, T, Lassila, R, Naukkarinen, M, Roine, RO, Syvänne, M, Taajamaa, B, Uurto, I, Ylitalo, A, Harjula, ALJ (eds) 2006, Angiologia, Recallmed, [Klaukkala].

2008 Harjula, A, Aarnio, P 2008, Käytännön lääkärin täsmähoidon ABC: diagnoosista terapiaan, Recallmed, Klaukkala.

2010 Vapaatalo, H, Vaajanen, A, Alajuuma, P, Oksala, O 2010, Does the renin-angiotensin system (RAS) regulate also intraocular pressure, The Open Proceedings Journal, 2nd International Conference on Drug Discovery and Therapy.

D2 Article in professional hand or guide book or in a professional data system, or text book material

2006 Jula, A, Kantola, I, Koivisto, P, Luostarinen, E, Mervaala, E, Niskanen, L, Olkinuora, J, Pyörälä, K, Ruskoaho, H, Tikkanen, I, Tuomilehto, J, Fyhrquist, F, Keinänen-Kiukaanniemi, S, Kukkonen-Harjula, K, Majahalme, S, Nieminen, M, Nissinen, A, Pentikäinen, P, Romo, M, Takala, J, Tikkanen, T, Turjanmaa, V 2006, 'Kohonnut verenpaine: Käypä hoito -suosituksen tiivistelmä', Kohonnut verenpaine. Käypä hoito -suosituksen tiivistelmä., vol. 122.

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

CardioMed/Mervaala

Välimäki, M, Alhava, E, Aro, H, Irjala, K, Heinonen, A, Hirvonen, E, Jousilahti, P, Kröger, H, Lamberg-Allardt, C, Malmivaara, A, Mattila, K, Mervaala, E, Möttönen, T, Salmela, P, Salmi, J, Salovaara, K, Savolainen, A, Suominen, H, Tuppurainen, M, Viikari, J 2006, 'Osteoporoosi: päivitetty Käypä hoito -suositus', Osteoporoosi. päivitetty Käypä hoito -suositus., pp. 1-24.

2010 Kantonen, IK, Kemppainen, E, Tikkanen, I 2010, 'Vatsa-aortan suurten sivuhaarojen sairaudet', in PJ Roberts, P Aarnio, K Höckerstedt, A Leppäniemi (eds), Kirurgia, 2. uud. p. edn, Kustannus Oy Duodecim, Helsinki, pp. 722-728.

E1 Popular article, newspaper article

2005 Ahtee, L, Airaksinen, M, Korpi, E, Neuvonen, PJ, Paakkari, I, Seppälä, T, Vapaatalo, H 2005, 'In memoriam: Mauri J. Mattila 16.12.1930-8.11.2005', Suomen lääkärilehti , vol 60, pp. 5182. Solatunturi, E, Vapaatalo, H 2005, 'In memoriam: Matti K. Paasonen 10.12.1925-7.4.2005', Suomen lääkärilehti , vol 60, no. 22, pp. 2520. Vapaatalo, H, Solatunturi, E 2005, 'Matti K. Paasonen *10.12.1925 +7.4.2005: in memoriam', Suomalainen Tiedeakatemia. Vuosikirja, pp. 133-135. Vapaatalo, H 2005, 'Pieni vaiva - hyvä mieli [kirja-arvostelu]', Suomen lääkärilehti , vol 60, no. 47, pp. 4902.

2007 Vapaatalo, H 2007, 'Bioaktiiviset peptidit ja verenpaine', Nutrifocus, no. 1, pp. 15-17.

2008 Mervaala, E 2008, 'SIRT1-aktivaatio: uusi keino metabolisen oireyhtymän ennaltaehkäisyyn?', Nutrifocus : ajankohtaisia ravitsemustutkimuksia, no. 2, pp. 12-13. Pilvi, T 2008, 'Maitoproteiinit ja kalsium: metabolinen oireyhtymä hallintaan ravinnolla', Nutrifocus : ajankohtaisia ravitsemustutkimuksia, no. 2, pp. 14-15. Ylitalo, P, Vapaatalo, H 2008, 'Poimintoja Suomen farmakologian historiasta: vuorossa Tampere', Transmitteri : Suomen farmakologiyhdistyksen jäsenlehti, vol 25, no. 85, pp. 8-11.

H1 Patents

2007 Harjula, A, Kankuri, EM, Bizik, J 2007, Method and device for treating or selecting cells, WO/2007/113387.

2008 Harjula, A, Kankuri, EM, Bizik, J, Vaheri, A 2008, Activated fibroblasts for treating tissue and/or organ damage, WO/2008/020119.

1 Analysis of activities 2005-2010 Associated person is one of Eero Mervaala , Riitta Anneli Korpela , Heikki Vapaatalo , Ari Harjula , Ilkka Tikkanen , Esko Markus Kankuri , Mika Laine , Piet Matias Finckenberg , Marjut Anneli Louhelainen , Agnieszka Biala , Juha Ketonen, Taru Kyllikki Pilvi , Erik Vahtola , Eveliina Tauriainen , Jin Shi , Pauliina Ehlers , Päivi Lakkisto , Jere Paavola , Antti Markus Siltanen , Kristo Nuutila , Matti Peura ,

Activity type Count

Supervisor or co-supervisor of doctoral thesis 97

Prizes and awards 7

Editor of research journal 17

Editor of research anthology/collection/conference proceedings 1

Peer review of manuscripts 2

Assessment of candidates for academic posts 3

Membership or other role in review committee 1

Membership or other role in research network 6

Membership or other role in national/international committee, council, board 44

Membership or other role in public Finnish or international organization 4

Membership or other role of body in private company/organisation 4

Other tasks of an expert in private sector 6

Participation in interview for written media 5 2 Listing of activities 2005-2010

Supervisor or co-supervisor of doctoral thesis Eero Mervaala , Supervisor of PhD thesis (Anna- Supervisor of PhD thesis (Teemu Helkamaa 2007),

Supervisor of PhD thesis (Marjut Louhelainen 2010),

Supervisor of PhD thesis (Eveliina Tauriainen 2011),

Supervisor of PhD thesis (Alyona Inzhutova), Eero Me

Riitta Anneli Korpela , Supervision of PhD thesis of Laura Paajanen, Riitta Anneli Korpela, 2005 Supervision of PhD thesis of Eveliina Myllyluoma, Riitta Anneli Korpela, 2007 Supervision of PhD thesis of Katja Hatakka, Riitta Anneli Korpela, 2007 Supervision of PhD thesis of Tiina Jauhiainen, Riitta Anneli Korpela, 2007 Supervision of PhD thesis of Kajsa Kajander, Riitta Anneli Korpela, 2008 Supervision of PhD thesis of Riina Kekkonen, Riitta Anneli Korpela, 2008

S Supervision of PhD thesis of Taru Pilvi, Riitta Anneli Korpela, 2009

Supervision of PhD thesis of

Supervision of PhD thesis of Pauliina Ehlers, Riitta Anneli Korpela, 2010 Heikki Vapaatalo , Väitöskirj

Väitöskirjatyö

Nigeria

Väitöskirjatyön ohjaus, Heikki Vapaatalo,

Väitöskirjatyön ohjaus, Heikki Vapaatalo, 1

Väitöskirjatyön ohjaus, Heikki Vapaatalo, 19

Supervisor of PhD thesis (Virpi Saareks 2001)

Superv

Supervisor of PhD thesis (Hanna Kotikosk

Supervisor of PhD thesis (Eveliina Myllyluoma 2007), Heikki Vapaatalo, 200

Supervisor of PhD

Supervisor of PhD thesis ( Pauliina Ehlers 2010), Heikki Vapaatalo, 2010 Ari Harjula ,

Advisor in academic dissertati

Adviso Ilkka Tikkanen ,

Supervisor of

Prizes and awards Eero Mervaala , Finnish Pharmacological Society Award Winner (2006), Eero Mervaala, 2006 Heikki Vapaatalo , Award of the Medical Society of Purkinye (Bronz Medal), Heikki Vapaatalo, 1

Maud Kuistila Award for Work as Postgraduate Trainer, Heikki

Editor of research journal Eero Mervaala , Member of Editorial Board (Hypertension 2003- Member of Editorial Board (Current Hypertension Reviews 2004- Member of Editorial Board (Open Hypertension Journal 2008-), Eero Merva Member of Editorial Board (ISRN Cardiology 2010- Member of Editorial Board (ISRN Pharmacology 2010- Member of Editorial Board (World Journal of Hypertension 2010-), Eero Mervaala Riitta Anneli Korpela ,

Ari Harjula , European Journal of Cardio-Th

The Journal of Heart and Lung Transplantation, Ari Harjula, 01 European Journal of Cardio-

The Journal

Editor of research anthology/collection/conference proceedings Eero Mervaala ,

Peer review of manuscripts Eero Mervaala , Peer review of scientic manuscripts in pharmacology and cardiovascular medicine (10-30 times annually between 2005-2010), Eero

Ilkka Tikkanen , Peer review of scientific manuscript in hypertension, cardiovascular medicine, and nephrology (5-10 annually 2005-2010), Ilkka

Assessment of candidates for academic posts Eero Mervaala , Nomination of docent (Eriika Savontaus 2008), Eero Mervaala, 2008, Finland Nomination of docent (Jaana Rysä 2008), Eero Mervaala, 2008, Finland Riitta Anneli Korpela , Farmakogenetiikan professuurin virantäyttöryhmä, Riitta Anneli Korpela, 2009

Membership or other role in review committee Eero Mervaala , Helsinki Biomedicinal Graduate School (HBGS), member of selection committee (2010), Eero Mervaala, 2010

Membership or other role in research network Eero Mervaala , BioCenter Kuopio (BCK), Finland, Member (2007- Riitta Anneli Korpela ,

Ilkka Tikkanen , Head, Unit of Cardiovascular Research, Minerva Institute for Medical Research, Helsinki (07/1997 -

Hypertension Group Director and Member in the Cardiovascular Risk Factors Research Program 2001-2006, Faculty of Medicine,

Head, Helsinki Hypertension Centre of Excellence, European Society of Hypertension (17.06.2008-

Membership or other role in national/international committee, council, board Eero Mervaala , Finnish Cardiac Society, Member of the Council of Cardiovascular Drug Therapy (2003- Finnish Cardiac Society, Secretary of Council of Cardiovascular Drug Therapy (2003- Finnish Hypertension Society, Board Member (2005-), Eero Finnish Hypertension Society, Secretary (2005- University of Kuopio, Post-graduate Training Committee, member (2006- Finnish Cardiac Society, Vice Chairman of Council of Cardiovascular Drug Therapy (2007- Finnish Hypertension Society, Vice President (2007- Kuopio University Hospital, Member of Ethical Committee (2007- Finnish Cardiac Society, Chairman of Council of Cardiovascular Drug Therapy (2008- Finnish Pharmacological Society (SFY), Board Member (2008- Finnish Hypertension Society, President (2009-2011), Eero Mervaala, 20

Institute of Biomedicine, Council Member (2010-2013), Eero Mervaala, 2010 Riitta Anneli Korpela ,

ETL Elintarviketeollisuusli

IDF International Dairy Federation Nutrition Research Group, Riitta Anneli Korpela, 0

President of, R

Ari Harjula , es

Finnish Society of Medicine, Ari Harjula,

Scandinavian Society of

2006

Scandinavian Society of Surgery, Ar

European Association for Cardio- Ilkka Tikkanen , Finnish Hypertension Society, Board Member (1989- Writing member in the Board of the Finnish Hypertension Guidelines Committee (2002-

Membership or other role in public Finnish or international organization Riitta Anneli Korpela ,

Heikki Vapaatalo , Ravitsemuksen tutkimussäätiö, Heikki Member of Scientific Advisor Board Valio Ltd (2005-

Membership or other role of body in private company/organisation Eero Mervaala , Representative of the Medical Research Foundation, Finland (2001- University Pharmacy of Kuopio, Board Member (2007- Pharmaceutical Information Centre, Medical Advisor (2008-), Eero Mervaala, 2008 Ari Harjula ,

Other tasks of an expert in private sector Eero Mervaala , Medical Advisor in Clinical Pharmacology (United Medix Medicinal Accident Committee (Lääkevahinkolautakunta), vice member (2005- Riitta Anneli Korpela , Private consultation practice, R

Participation in interview for written media Riitta Anneli Korpela ,

Heikki Vapaatalo , lehti: Pharmacia & Upjohnin Now -uutislehti, Heikki Vapaatalo, 2006, Finland Taru Kyllikki Pilvi , Kauneus ja terveys, Taru Kyllikki Pilvi, 01.12.2006, Finland Kemia-lehti, Taru Kyllikki Pilvi, 01.03.2006, Finland Yliopisto-lehti, Taru Kyllikki Pilvi, 01.12.2006, Finland INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010

by CWTS, Leiden University, the Netherlands

Research Group: Mervaala E

Basic statistics Number of publications (P) 173 Number of citations (TCS) 1,643 Number of citations per publication (MCS) 9.67 Percentage of uncited publications 23% Field-normalized number of citations per publication (MNCS) 1.30 Field-normalized average journal impact (MNJS) 1.00 Field-normalized proportion highly cited publications (top 10%) 1.35 Internal coverage .93

Trend analyses

MNCS

THCP10 MNJS

Collaboration

Performance (MNCS) by collaboration type INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010

by CWTS, Leiden University, the Netherlands

Research profile

University of Helsinki Administrative Publications 80/37 Evaluations

ISBN 978-952-10-7457-8 (PDF) ISSN 1795-5513 (Online)

Internet address: http://www.helsinki.fi/julkaisut/aineisto/rc_evaluation2012/hallinnon_julkaisuja_80_37_2012.pdf