International Quality Assurance Programme (Iqap)

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary Report

SEIZED MATERIAL 2013/2 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Table of contents Introduction Page 2 Comments from the International Panel of Forensic Experts Page 2 Codes and Abbreviations Page 4 Sample 1 Analysis Page 6 Identified substances Page 6 Statement of findings Page 10 Identification methods Page 19 Summary Page 23 Z-Scores Page 24 Sample 2 Analysis Page 27 Identified substances Page 27 Statement of findings Page 30 Identification methods Page 39 Summary Page 43 Z-Scores Page 44 Sample 3 Analysis Page 46 Identified substances Page 46 Statement of findings Page 49 Identification methods Page 57 Summary Page 62 Z-Scores Page 63 Sample 4 Analysis Page 65 Identified substances Page 65 Statement of findings Page 66 Identification methods Page 74 Summary Page 78 Test Samples Information

Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 38.6% w/w heroin base.The seizure also contained acetyl codeine,6-monoacetylmorphine glucose and trace amounts of codeine and morphine

Sample 2 SM-2 was prepared from a seizure containing 4.9% w/w amphetamine base.The seizure also contained caffeine and creatinine.

Sample 3 SM-3 was prepared from a seizure containing 82.1% w/w 1-(3-chlorophenyl)piperazine base.The seizure also contained trace amounts of codeine and morphine.

Sample 4 SM-4 was prepared from the diluent lactose

Samples Substances Concentrations Comments on substances Sample 1 Heroin 38.6 % Sample 2 Caffeine 0 % Amfetamine 4.9 % Sample 3 1-(3-Chlorophenyl)piperazine 82.1 % Sample 4 Lactose 0 %

This report contains the data received from laboratories participating in the current exercise. The results compiled in this report are not intended to be an overview of the quality of work and cannot be interpreted as such. These comments do not reflect the general state of the art within the profession.

Participant results are reported using a randomly assigned "WebCode". This code maintains participant's anonymity, provides linking of the various report sections, and will change with every report.

Introduction

An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. Two rounds are offered per year with each round presenting participants with four different test samples for analysis. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

Comments from the International Panel of Forensic Experts

Participation of Laboratories

Samples within both the Seized Materials (SM) and Biological Specimens (BS) test groups were sent to 165 laboratories in 59 countries. Within the SM test group, samples were sent to 136 laboratories and 131 laboratories (96%) submitted the results of their analysis in time for inclusion in the summary report, with 128 (98%) using the ICE portal for return of results..

Qualitative Analysis

The results for the qualitative identification of the ICE menu substances were good for all test samples in the SM group. 98% and 95 % of participants correctly identified the heroin and amphetamine in SM-1 and SM-2 respectively. It is encouraging to note that 94% of participants identified the 1-(3-chlorophenyl)piperazine in SM-3, indicating an excellent level of awareness of participants in the identification of this New Psychoactive Substance (NPS). As the ICE programme develops, UNODC will include further examples of representative NPS in the ICE menu to assist participants in their analysis and detection of emerging substances. ICE participants are encouraged to use the UNODC Early Warning Advisory on New Psychoactive Substances http://www.unodc.org/nps, to report NPS detected in their laboratories. This information will greatly assist UNODC to further target its technical assistance to ICE participants. SM-4 was a blank test sample containing no substances in the ICE menu.

Overall, 90% of participants overall used GC-MS for the qualitative analysis indicating wide access to this technique which is one of the most commonly used tandem techniques for the confirmation of controlled substances. It is encouraging to note that only 15 false positive results were reported for the four test samples in the SM group, while there were also only 9 false negative results. The detection limits of the different analytical techniques are taken into consideration when ascribing false positive results and as such laboratories who detected the trace amounts of morphine in SM-1 and morphine and/or Codeine in SM-3 should not consider their results as false positives.

Quantitative Analysis A modified Z-score was used for the statistical examination of the quantitative results, as it is a robust method based on absolute deviations from the median of all participant values and is relatively insensitive to outliers. Test samples in the previous three successive rounds of ICE have contained heroin and the percentages of laboratories performing quantification for this substance has remained stable at 68% for ICE 2012/1, 70% for ICE 2012/2, 68% for ICE 2013/1 and 71% for this current round. As 1-(3- chlorophenyl)piperazine is a new substance on the ICE test samples for this current round, it is encouraging to see 29% of laboratories already performing quantitative analysis for this drug. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution.

Analysis of the Z-scores showed that 83 out of 93 (89%) of participants provided acceptable quantitative results with Z-scores within 3.5 for heroin in SM-1, 69 out of 75 (92%) for amphetamine in SM-2 and 29 out of 37 (78%) laboratories for 1-(3-chlorophenyl)piperazine in SM-3. Participants with Z-scores outside acceptable limits should review their quantification procedures. INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

71% of participants in this round quantified at least one test sample and 27% quantified all three test samples. The predominant analytical techniques used by participants for quantification within the SM test group were GC-FID (51%), followed by HPLC (24%). Z-score values obtained from quantitative analysis assist participating laboratories in evaluating their performance and Z-scores should be monitored over time as part of each laboratory’s quality assurance programme.

(4) INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Codes and Abbreviations

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained. (-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.

Tech Code Name 140 Colorimetric reactions 141 Marquis reagent (sulphuric acid, formaldehyde) 142 Cobalt thiocyanate 150 Thin Layer Chromatography 160 High/Ultra High Performance Liquid Chromatography 161 High Performance Liquid Chromatography with diode array detection 170 Gas Chromatography NPD 171 Gas Chromatography FID 172 Gas Chromatography ECD 180 Gas Chromatography/Mass Spectrometry 190 Fourier Transform Infrared Spectrometry 200 Spectrophotometry (visible, UV) 210 Others (specify) 211 NMR 220 Microcrystal test 230 Liquid chromatography/mass spectrometry 231 Liquid chromatography/tandem mass spectrometry

Sample 1 Analysis

Identified substances for Test Sample 1

Code Identified Substances 0DA6JO HEROÍNA + CANABIDIOL 0NNGO4 Heroin 0YFLNL Heroin 144FAB diamorphine hydrochloride 192GH2 Heroin 28NZ22 Heroin 2EQC6Q Heroin 2UUUXU Heroin 3DVBVE Heroin 3LN2N9 Heroine 44VN4T Heroin Hydrochloride 4CVIID Heroin 4Y4BMB Heroin 5AKBA5 heroin chlorhydrate 5DMOWW Heroïn 5OHSAB DIACETYLMORPHINE 5V2K55 heroine, 6-MAM, Acetylcodeine 66P66H eroina 6AAAIA Heroin, 6-MAM, Acetylcodeine 7JPM7K heroin 7NMYY7 Heroin 815B51 HEROINA 9999JM heroin 9AT7DN Heroin & Morphine (trazes) 9S9R99 Heroin A4DVDD Heroin AC6AA0 Heroin ARRBBM Heroine AXAVAA heroin B11A58 Heroine,HCl BR66FX Heroin C6UZN1 heroin CFILQS heroin hydrochloride CITDQT Acetylcodeine, 6-Monoacetylmorphine, Codeine, Morphine and Delta-9-THC CMQISC heroin CPCFME Heroin DFLETW Heroin DGEIFI Diamorphine HCl DWGQZS héroine E4AF6Q Heroin

Code Identified Substances E5B6AC Morphine EOZOOO Heroin, monoacetylmorphines and codeine G7GGCR heroin GGWXWW Diamorphine (Heroin) GULHNN Heroin, Monoacetylmorphines GZDUQM Heroin HBHUNI Heroine+Acetlcodeine+6MAM HE2TG2 Heroin HHHHU5 DIAMORPHINE HYDROCHLORIDE HHRTHH Heroin HVXZXL Heroin/Morphine HWGQ3X Heroin, Acetylcodeine, 6-Monoacetylmorphine I5IP07 HEROIN IAWA6A heroin IBOQKX Heroin II8JO4 Heroin IP12QF Heroin JDDD6D Heroin JJRRVN heroin JKBKRK Heroin JPIPOT Heroine JRLS5J heroin, morphine JSHHOS Diamorphine JSZMHJ Base Heroin JYDFMU heroin KKQS2K heroin LLCQXL 6-Monoacetylmorphine and Heroin LQEYRY heroin, morphine, codein, 6-acethylcodein, 6-acethylmorphine N0TYZE Heroin NBNVJG HEROIN NNVNSC heroin NRVAVR HEROIN NVUXXR Heroin NZMVTG Diamorphine O0NJNN Diacetyl morphine ODFBYE HEROIN 36%, MORPHINE 2,6% , 6-MONOACETYLMORPHINE OF0Q00 Heroin OOAION Heroin, Morphine OOIOUO Heroin, Acetyl Codeine, Mono Acetyl Morphine and Morphine P04CR4 Heroin PCR99G heroin and 6-monoacetylmorphine PDMMHM HEROIN PWYKZQ Heroin QMG6MM Heroïn

Code Identified Substances QPEFZE Heroin QRPRRR heroin hydrochloride QXZKSQ Heroin R21VX8 Heroin RBFBBM Heroin, Acetylcodeine, 6-Monoacetylmorphine RRR6HI HEROIN RSNKH3 heroin SL61P0 Heroin SLJETI heroin SUA1EC heroin SZT4VF heroine SZVCHI heroin T3A33W Heroin UBJZMK Heroin UGGGBT heroin UOBROB Heroina UVIZDN Heroin,Morphine UY78GL HEROÍNA UYAC2L Heroin VDZ8NV Heroína VWU2B0 heroin W4B4QT Heroin WABFAA heroin WEEH53 heroin WELQMQ heroin WLPRZL heroin WLZJLF Heroína y Acetilcodeína WM8MGO HEROÍN WTCTPT Heroin WUAUUU heroin WVBNU6 heroin, ACETILCODEINE WWWH4N Heroin HCl X3UUYH heroine,6-monoacetylmorphine,Acetylcodeine X8WVVF heroin, monoacetylmorphine XDOWHP heroin XLL0OS heroine XNSNEU Heroin XPOMU1 HEROIN XSNG6F Heroin XXR4ZM Heroin Y6T66I heroine YXMHT9 heroin HCl YXXRY9 Heroin Z0BIZI Heroin

Code Identified Substances Z1SAXE heroin ZLFXWZ Heroin

Statement of findings for Test Sample 1

Code Heroin 0DA6JO + De los análisis realizados se concluye que el polvo blanco se trata de una mezcla que contiene heroína y canabidiol. 0NNGO4 +

0YFLNL + 1 glass bottle containing 0.23 grammes of a mixture containing 0.08 grammes of heroin hydrochloride (being a salt of heroin). 144FAB + A white powder containing an average of 41% of diamorphine hydrochloride 192GH2 + The sample contains heroin, 6MAM, acetyl codeine and dextrose. 28NZ22 + The sample contains heroin (36.1%), acetylcodeine and 6-monoacetylmorphine. 2EQC6Q + The sample also contained acetylcodeine, 6-monoacetylmorphine. 2UUUXU + After analysing the sample with colourimetric tests, MSD confirmation and subsequent quantification by chromatography with FID detector, we are confident that the SM-1 sample contains 29.59 % heroin base 3DVBVE +

3LN2N9 + contained heroine, acetylcodeine and 6-monoacetylmorphine 44VN4T + Heroin hydrochloride and dextrose confirmed in one unit tested of one unit recieved. 4CVIID + In the test sample 2013/2/SM-1 were detected heroin, 6-monoacetylmorphine and acetylcodeine 4Y4BMB + acetyl-codeine 5AKBA5 + glucose, acetylcodeine, monoacetylmorphine 5DMOWW + Find also acetylcodeine and glucose. Heroïn is a drug of abuse. Acetylcodeine comes from acetylation of codeine coming from opium. Glucose is a sugar 5OHSAB + Was found too ACETYLCODEINE

Code Heroin 5V2K55 +

66P66H +

6AAAIA + Illegal substances on the basis of the italian law DPR 309/90 7JPM7K +

7NMYY7 +

815B51 + LA MUESTRA DE POLVO BLANCO ES UNA MEZCLA DE HEROINA Y LACTOSA 9999JM + Sample contains 36.4 ± 2.2 w/w heroin base in HCL salt form. 6-MAM and acetyl-codeine were also detected. 9AT7DN + It was also detected: 6-MAM, acetylcodeine and codeine. However, it wasn't detected noscapine and papaverine, natural opiates found in Papaver somniferum. No adulterants were found. 9S9R99 + We found heroin in SM-1 as controlled drugs A4DVDD + The sample 2013/2/SM-1 contains Heroin detected by GC-MS. The percentage by weight of Heroin is 35.8%. detected by GC-FID. AC6AA0 + Heroin was identified by TLC and GC/MS ARRBBM +

AXAVAA +

B11A58 + the powder contains heroine chlorhydrate with glucose BR66FX + The sample contains heroin. The percentage by weight of heroin (as base) is 34.3%. C6UZN1 + 6-monoacetylmorphine, acetylcodeine

Code Heroin CFILQS + sample 1 contains Heroin HCl (35,5% as base) cut with glucose. We also identify o-6 MAM, acetylcodeine and codeine. CITDQT - Major compounds detected are Acetylcodeine and 6-Monoacetylmorphine. No quantitation performed. CMQISC +

CPCFME + On analysis, I found the sample to contain diamorphine. (Under Irish legislation, heroin is controlled as diamorphine) DFLETW +

DGEIFI + This powder contained an average of 36% DIAMORPHINE (commonly known as 'heroin') together with the adulterant glucose. DWGQZS + acétyl codéine, 6-mono acetylmorphine, dextrose E4AF6Q + Heroin, acetylcodein, monoacetylmorphine and glucose E5B6AC - Marquis reagent have been apllied, TLC (Thin Layer Chromatography) for opiaces, cocaine and the GC/FID EOZOOO + Based on the above analysis, the sample was found to contain 36.3 % heroin. The sample also found to contain monoacetylmorphines, acetylcodeine and codeine. G7GGCR + glucose GGWXWW + The powder was analysed and found to contain Diamorphine. A portion of the powder was further analysed and found to contain Diamorphine. GULHNN + On analysis, I found the substance to contain 37.1% of Heroin GZDUQM + Sample 2013/2/SM-1 consists of white powder. Heroin, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. The seizure also contains acetylcodeine, 6-mono-acetyl-morphine and traces of morphine. HBHUNI + Powder containg Heroine, Acetylcodeine and 6MAM HE2TG2 + Presence of chlorides

Code Heroin HHHHU5 + Test Sample 2013/2/SM-1 - one vial containing off-white powder. This powder contained an average of 44% DIAMORPHINE HYDROCHLORIDE. HHRTHH + SM1 contain Heroin.HCl HVXZXL + Heroin and morphine detected in SM-1.Heroin content is 34.18% and morphine content is 0.61%. HWGQ3X + Color Test: Marquis' --> violet; Mecke --> deep green; Froehde---> purple TLC & GCMS: Heroin, Acetylcodeine, 6-Monoacetylmorphine GC: Heroin Base 36.83% I5IP07 + HEROINE HYDROCHLORIDE 36.4 %( as BASE ), GLUCOSE IAWA6A + acetyl-codeine and 6-MAM IBOQKX + This sample is heroin. II8JO4 + Powder was found to contain diamorphine at a concentration of 37%. Diamorphine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class A drug. IP12QF + The sample is a preparation that contains heroin. JDDD6D + The test sample 2013/2/SM-1 was analysed by colour test and Thin layer Chromatography techniques and found to contain Heroin. JJRRVN + The sample was found to contain heroin. JKBKRK + 0.234grams of a powder containing 41% Diamorphine. Diamorphine is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971. JPIPOT + The sample SM1 contained 36.5 % calculated as a base. In the sample was identified glucose and codeine. JRLS5J + The sample contains heroin, morphine and codeine which are scheduled as illicit drugs in France. Glucose is a cutting agent. JSHHOS + The powder was analysed and found to contain diamorphine. JSZMHJ + Base Heroin 37,11+/- 4,31 % (w/w), Acetylcodeine; 6-momoacetylmorphine and Glucose

Code Heroin JYDFMU + acetylcodein, mono acetylmorphin, glucose KKQS2K + acetylcodein, 6-monoacetylmorphine LLCQXL + On analysis, I found the substance to contain 6-Monoacetylmorphine and Heroin. Quantitative analysis was not carried out to determine the weight of the drugs. LQEYRY + We also found glucose N0TYZE +

NBNVJG + ACETILCODEINA Y 6-MONOACETILMORFINA NNVNSC + heroin with glucose NRVAVR + The sample 2013/2/SM-1 was found to contain Heroin. NVUXXR + Narcotics: Heroin (I) (the number refers to legislation) Concentration: 41 % heroinhydrochloride Amount: 0,2 gram NZMVTG + The sample was found to contain 37.7% of diamorphine (as base). O0NJNN + Test sample 2013/2/SM1 was found to contain Heroin which is a controlled drug. ODFBYE + ACETYLCODEINE, CODEINE OF0Q00 + The sample contain heroin. The dample contain traces of acetyl-codeine and 6-monoacetylmorphine OOAION + - OOIOUO + Examination revealed the presence of illicit heroin OQ2JQM +

Code Heroin P04CR4 + -The sample obtains with the positive result with Marquis reagent. - TLC: The Rf sample obtain with the same Rf Heroin Standard. - GC: The Rt sample obtain with the same Rt Heroin Standard. PCR99G + the sample also contains heroin, 6-monoacetylmorphine and acetylcodeine PDMMHM + TRACES OF CODEINE, MORPHINE, ACETYLCODEINE AND 6-MAM WERE IDENTIFIED PWYKZQ + Acetylcodeine and 6-monoacetylmorphine QMG6MM +

QPEFZE +

QRPRRR + the presence of drug confirmed by GC-MS and FTIR analysis, the hydrochloride form confirmed by the anion analysis QXZKSQ + The sample contains heroin which is listed as a controlled drug according to french order, appendix I of February 22nd 1990. R21VX8 + GC MS AND NPD RBFBBM +

RRR6HI + HEROIN as base 35.7% - GLUCOSE RSNKH3 + White powder containing Heroin (38%ww) and 6-monoacetylmorphine (0.9%ww) controlled by national law. In addition also acetylcodeine is present SL61P0 + Acetylcodeine, Monoacetylmorphine (MAM) SLJETI +

SUA1EC + 6-MAM, acetil-kodein SZT4VF + sample contains heroine hydrochloride (30,64% of heroine base)

Code Heroin SZVCHI + positive to marquis reagent: violet retention time as our pattern of heroin T3A33W +

UBJZMK + Heroin (diacetylmorphine) was detected at 35.61% UGGGBT + the sample was performed by UV, tlc, Gc ms and also contains 6 Monoacetyl morphine and acetyl codeine UOBROB +

UVIZDN + In this sample contain five substance .Heroin,Morphine,6monoacetylmorphine,Acetylcodeine and Glucose UY78GL + LA MUESTRA AL SER ANALIZADA SE ENCONTRO QUE CONTIENE HEROÍNA UYAC2L + Heroin and lactose VDZ8NV + se le realizó pruebas de marquis, scott, lieberman´s, Mad4linn´s, también microcristales con cloruro de mercurio al 2%, FT-IR, UV VWU2B0 +

W4B4QT + Heroin + acetylcodeine. Heroin=38% +-4% as free base WABFAA + heroin, morphinan, 6-monoacethylmorphin WEEH53 + white powder containing 35.7%ww of heroin WELQMQ +

WLPRZL + the result of TLC and IR of test sample was shown same as those of the reference substance of heroin. WLZJLF +

Code Heroin WM8MGO + The results of the tests of the SM1 (81) received confirmed that the mentioned sample contains heroin with 35.1percentage by weight (35.1%) WTCTPT + Heroin is controlled by law (KB 31/12/1930, changed by KB 8/10/1963) WUAUUU + white powder, other alkaloid acetylcodeine, glucose (dextrose) as diluent ingredient WVBNU6 +

WWWH4N + SM 1 contains: Acetylcodeine, 6-monoacetylmorphine, Glucose. Trace amounts of Morphine could be detected

X3UUYH +

X8WVVF + white powder containing 34.8%ww heroin and 5.8%pp monoacetylmorphine (MAM). Acetylcodeine and glucose are present. XDOWHP + the powdre is a mixture of heroin, other opiates and glucose. The concentration of heroin in the sample is 37.5% by weight XLL0OS + acetylcodeine, 06-monoacetylmorphine and lactose XNSNEU + Presence of heroin hydrochloride, acetilcodeine and glucose was detected in the sample. XPOMU1 +

XSNG6F + Sample 2013/2/SM-1 was found to contain Heroin a Schedule I drug under the Single Convention on Narcotic Drugs. The sample was also found to contain Acetylcodeine. XXR4ZM + Sample 2013/2/SM-1,a white odorless powder, was found to contain Heroin, a controlled substance under National Law. Y6T66I + The sample also contains acetylcodeine, 6-monoacethylmorphine YXMHT9 + acetylcodeine YXXRY9 + White powder containing Heroin and traces of Acetyl-codeine, Monoacetylmorphine and Morphine

Code Heroin Z0BIZI +

Z1SAXE + found heroin 39.9%ww, 6-monoacetylmorphine and 6-acetylcodeine ZLFXWZ + On analysis, I found the substance to contain 36.4% Heroin

Identification methods for Test Sample 1

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Analytical Technique Codes Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 0DA6JO S S S I SI Ion Mobility Spectrometry 0NNGO4 S I I 0YFLNL S S SI I 144FAB S S I I 192GH2 S S I I 28NZ22 S S S I I 2EQC6Q SI I 2UUUXU S I 3DVBVE S I I 3LN2N9 SI 44VN4T I SI I I 4CVIID I I I 4Y4BMB S I I 5AKBA5 SI 5DMOW I SI I W 5OHSAB S S S I I 5V2K55 I SI 66P66H SI SI 6AAAIA I I 7JPM7K I 7NMYY7 SI S I 815B51 S I I I ESPECTROMETRIA DE MASAS/INSERCION DIRECTA 9999JM I S I SI SI 9AT7DN I SI I I 9S9R99 S I I A4DVDD SI I AC6AA0 S S S I I ARRBBM SI I AXAVAA S S S SI B11A58 I SI I BR66FX SI I I C6UZN1 S SI I I CFILQS S S I I

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 CITDQT S I S Simon's CMQISC S I I CPCFME I SI DFLETW I SI DGEIFI S S I I DWGQZS SI I E4AF6Q S I E5B6AC SI S S I I EOZOOO S I I G7GGCR S S S I I I GGWXW S I W GULHNN S I I GZDUQM S S I I I I HBHUNI SI I I HE2TG2 S S SI I HHHHU5 S S I I HHRTHH S S S I HVXZXL I I I S colloidal gold HWGQ3X S S I I I I5IP07 S S I I IAWA6A I SI I IBOQKX S I I II8JO4 S S I I IP12QF I S I JDDD6D S S I I A JJRRVN S I I JKBKRK S S I I JPIPOT I I JRLS5J S S I I JSHHOS S S I I JSZMHJ S I I I XRD JYDFMU SI SI KKQS2K S I S LLCQXL S I LQEYRY SI I N0TYZE SI NBNVJG S I I NNVNSC I I NRVAVR S S S I I

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 NVUXXR SI I NZMVTG SI I LC/ELSD O0NJNN SI ODFBYE SI SI SI I I I OF0Q00 SI ASAP-TOF OOAION SI OOIOUO S SI OQ2JQM S S S I I P04CR4 S S S I I PCR99G S S I I PDMMHM I SI I PWYKZQ I SI QMG6MM I SI SI QPEFZE S S S I I I S QRPRRR S S I I I QXZKSQ I I R21VX8 I SI RBFBBM S I I RRR6HI S S S I I I RSNKH3 I SI SL61P0 I SI SLJETI SI SUA1EC S SI I I SZT4VF S SI I I I I SZVCHI S I T3A33W S S I I SI UBJZMK S S I I UGGGBT S I I UOBROB S I I UVIZDN S S S I I UY78GL S I I UYAC2L SI I VDZ8NV S S S I I I I VWU2B0 SI S S I I W4B4QT S S I I WABFAA SI SI I I I WEEH53 I SI WELQMQ SI I WLPRZL I I SI

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 WLZJLF S SI S I I WM8MG SI SI SI I O WTCTPT I S WUAUUU SI I WVBNU6 SI SI I I WWWH4 I S I I N X3UUYH S S S I I X8WVVF I SI XDOWHP I I I SI I I xrd XLL0OS SI SI I I I XNSNEU S S S S I I I XPOMU1 I I SI FPIA XSNG6F S I XXR4ZM S S I I Y6T66I S I I I YXMHT9 I I S ATR YXXRY9 S I SI SI I Z0BIZI S I I Z1SAXE SI ZLFXWZ S I I

Summary for test sample 1 The response summary of all 130 participating laboratories for the identification of SM-1, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 1:

Response Summary Participants: 131

Heroin: 129

False positives for Test Sample 1

Code Name Technique 0DA6JO Cannabidiol Ion mobility spec CITDQT ¨7+& 180

False negatives for SM-1 (techinque(s) used or ANP)

Code: CITDQT (180) E5B6AC (171)

Frequency of use of screening and identification techniques: Response Summary Participants: Response Summary 130 Participants: 131 142 150 160 161 170 Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 Screening 43 54 39 16 0 2 0 2 41 8 1 0 0 0 6 32.8% 41.2% 29.8% 12.2% 0.0% 1.5% 0.0% 1.5% 31.3% 6.1% 0.8% 0.0% 0.0% 0.0% 4.6% Identification 12 6 3 30 6 15 3 20 118 70 2 3 2 3 9 9.2% 4.6% 2.3% 22.9% 4.6% 11.5% 2.3% 15.3% 90.1% 53.4% 1.5% 2.3% 1.5% 2.3% 6.9% # labs using 48 54 40 39 6 16 3 21 118 73 3 3 2 3 11 this technique 36.6% 41.2% 30.5% 29.8% 4.6% 12.2% 2.3% 16.0% 90.1% 55.7% 2.3% 2.3% 1.5% 2.3% 8.4%

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 1

Heroin Heroin MAD: 1.5 CODE MAD: 1.5 CODE Conc. * AbsDev ZScore Conc. * AbsDev ZScore 24.5 12.0 5.6 0YFLNL 32.4 4.1 1.9 IP12QF 35.7 0.8 0.3 144FAB 35.0 1.5 0.7 JJRRVN 41.0 4.6 2.1 192GH2 44.3 7.8 3.7 JKBKRK 36.5 0.0 0.0 28NZ22 36.1 0.4 0.2 JPIPOT 38.0 1.6 0.7 2EQC6Q 37.3 0.8 0.4 JRLS5J 37.1 0.7 0.3 2UUUXU 35.2 1.3 0.6 JSZMHJ 52.2 15.8 7.3 3DVBVE 34.2 2.3 1.1 JYDFMU 38.9 2.4 1.1 3LN2N9 37.2 0.8 0.3 LQEYRY 29.0 7.5 3.5 44VN4T 35.2 1.3 0.6 N0TYZE 37.3 0.8 0.4 4CVIID 37.0 0.5 0.3 NNVNSC 37.0 0.5 0.3 4Y4BMB 34.7 1.8 0.8 NVUXXR 37.7 1.3 0.6 5AKBA5 35.0 1.5 0.7 NZMVTG 36.0 0.5 0.2 5DMOWW 22.4 14.1 6.5 ODFBYE 41.5 5.1 2.4 5V2K55 37.9 1.5 0.7 OOAION 35.4 1.1 0.5 66P66H 19.0 17.5 8.1 OOIOUO 57.0 20.5 9.6 6AAAIA 30.7 5.8 2.7 P04CR4 40.3 3.8 1.8 7NMYY7 32.9 3.6 1.7 PCR99G 36.7 0.3 0.1 9999JM 36.4 0.1 0.0 PDMMHM 34.6 1.9 0.9 9AT7DN 32.7 3.7 1.7 PWYKZQ 37.3 0.8 0.4 A4DVDD 35.8 0.7 0.3 QMG6MM 67.0 30.6 14.2 AC6AA0 35.6 0.9 0.4 QPEFZE 33.2 3.3 1.5 AXAVAA 40.7 4.3 2.0 QRPRRR 37.1 0.6 0.3 B11A58 36.6 0.1 0.1 QXZKSQ 35.4 1.1 0.5 BR66FX 34.3 2.2 1.0 RBFBBM 35.7 0.8 0.4 CFILQS 35.5 1.0 0.4 RRR6HI 38.0 1.6 0.7 CPCFME 33.6 2.9 1.3 RSNKH3 35.5 1.0 0.4 DFLETW 38.4 2.0 0.9 SL61P0 30.6 5.8 2.7 DGEIFI 36.0 0.5 0.2 SZT4VF 35.0 1.4 0.7 DWGQZS 37.8 1.3 0.6 SZVCHI 35.6 0.8 0.4 E4AF6Q 39.3 2.8 1.3 UBJZMK 65.7 29.2 13.6 EOZOOO 36.3 0.2 0.1 VDZ8NV 36.0 0.5 0.2 G7GGCR 39.4 3.0 1.4 VWU2B0 38.0 1.6 0.7 GGWXWW 36.0 0.5 0.2 W4B4QT 38.0 1.6 0.7 GULHNN 37.1 0.6 0.3 WABFAA 35.7 0.8 0.3 HHHHU5 38.0 1.6 0.7 WEEH53 54.2 17.8 8.3 HHRTHH 41.3 4.8 2.3 WELQMQ 46.0 9.6 4.4 HVXZXL 34.2 2.3 1.1 WLPRZL 32.7 3.8 1.7 HWGQ3X 36.8 0.4 0.2 WM8MGO 36.6 0.1 0.1 I5IP07 36.4 0.1 0.0 WTCTPT 38.0 1.6 0.7 IBOQKX 36.7 0.2 0.1 WUAUUU 35.9 0.6 0.3 II8JO4 37.0 0.5 0.3 WWWH4N X3UUYH 37.0 0.5 0.3 2013/2-SM (24) INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Heroin MAD: 1.5 CODE Conc. * AbsDev ZScore X8WVVF 34.8 1.7 0.8 XDOWHP 37.5 1.1 0.5 XLL0OS 38.0 1.6 0.7 XNSNEU 30.0 6.5 3.0 XSNG6F 36.0 0.5 0.2 XXR4ZM 29.1 7.4 3.4 Y6T66I 36.2 0.3 0.1 YXMHT9 39.0 2.6 1.2 Z1SAXE 39.9 3.5 1.6 ZLFXWZ 36.4 0.1 0.0

*) Concentration: w/w %

Z-Score has been calculated as modified Z-Score as it is a robust method and therefore relatively insensitive to outliers. Modified Z-Score = 0.6745 * AbsDev/MAD AbsDev = Absolute value of the difference between a laboratory value and the median of all the laboratory values for the given drug; MAD = median absolute deviation about the median. Modified Z-scores with an absolute value of greater than 3.5 should be considered as potential outliers. Reference: Iglewicz, B. and Hoaglin, D. C.: 1993 How to Detect and Handle Outliers, American Society for Quality Control, Milwaukee, WI

Round: 2013/2 Substance: SM-1/Heroin Median = 36.4 MAD = 1.5 UNODC value = 38.6

Sample 2 Analysis

Identified substances for Test Sample 2

Code Identified Substances 0DA6JO ANFETAMINA 0NNGO4 caffeine 0YFLNL Amphetamine 144FAB amphetamine 192GH2 Amphetamine 28NZ22 Amfetamine 2EQC6Q Amfetamine 2UUUXU Amhetamine 3DVBVE Amphetamine 3LN2N9 amfetamine 44VN4T d,l-amphetamine 4CVIID Amfetamine 4Y4BMB amphetamine 5AKBA5 amphetamine sulfate 5DMOWW amfetamine sulfate 5OHSAB Benzeneethanamine, N-methyl; N-acetylamphetamine 5V2K55 Amphetamine 66P66H amfetamina 6AAAIA Amphetamine 7JPM7K amphetamine 7NMYY7 Amfetamine 815B51 ANFETAMINA - CAFEÍNA 9999JM amphetamine 9AT7DN Amfetamine 9S9R99 amphetamine A4DVDD Amfetamine and Caffeine AC6AA0 Amphetamine ARRBBM Amphetamine AXAVAA amphetamine B11A58 Amphétamine BR66FX Amphetamine C6UZN1 amphetamine CFILQS Amfetamine sulfate CITDQT Amphetamine CMQISC amfetamine CPCFME Amphetamine DFLETW Amfetamine DGEIFI Amphetamine and caffeine DWGQZS éthylamphétamine E4AF6Q Amphetamine

Code Identified Substances E5B6AC Caffeine and derivates amphetamines EOZOOO Amphetamine G7GGCR amfetamine GGWXWW Amphetamine GULHNN Amphetamine GZDUQM Amfetamine HBHUNI Amfetamine HE2TG2 Amphetamine, caffeine HHHHU5 AMPHETAMINE HHRTHH Amphetamine HVXZXL Amfetamine/Caffeine HWGQ3X Amphetamine Sulfate I5IP07 AMPHETAMIN IAWA6A amphetamine IBOQKX Amphetamine II8JO4 Amphetamine IP12QF amphetamine, caffeine JDDD6D Amfetamine and Caffeine JJRRVN amfetamine JKBKRK Amfetamine JPIPOT Amphetamine JRLS5J amfetamine, caffeine JSHHOS Amphetamine JSZMHJ Amfetamine sulphate JYDFMU amphetamine KKQS2K amfetamine LLCQXL Amphetamine and caffeine. LQEYRY caffein and amphetamine NBNVJG ANFETAMINA NNVNSC amfetamine NRVAVR Amfetamine. Caffeine. NVUXXR Amphetamine NZMVTG Amphetamine O0NJNN Caffeine ODFBYE AMPHETAMINE 4,4% AND CAFFEINE OF0Q00 Amphetamine OOAION Amfetamine OOIOUO Amphetamine P04CR4 Amphetamine PCR99G amphetamine PDMMHM AMPHETAMINE PWYKZQ Amfetamine QMG6MM Amfetamine QPEFZE Amfetamine

Code Identified Substances QRPRRR amphetamine sulphate QXZKSQ Amfetamine R21VX8 Amfetamine ,Caffeine RBFBBM Caffeine RRR6HI AMPHETAMINE RSNKH3 amphetamine SL61P0 Amphetamine SLJETI amphetamine SUA1EC ampetamine SZT4VF amphetamine SZVCHI amfetamine T3A33W Amphetamine UBJZMK Amfetamine UGGGBT amphetamine UOBROB Anfetamina UVIZDN Amphetamine UY78GL ANFETAMINA, CAFEINA UYAC2L Amfetamine VDZ8NV cafeína VWU2B0 amfetamine W4B4QT amphetamine WABFAA amfetamine WEEH53 amfetamine WELQMQ A WLZJLF Anfetamina WM8MGO AMPHETAMINE WTCTPT amphetamine WUAUUU amphetamine WVBNU6 CAFEINE WWWH4N Amphetamine sulphate X3UUYH Amfetamine X8WVVF amphetamine XDOWHP amphetamine XLL0OS amphetamine XNSNEU Amfetamine XPOMU1 AMPHETAMINE XSNG6F Amphetamine XXR4ZM Amphetamine Y6T66I amphethamine YXMHT9 amphetamine sulfate YXXRY9 Amphetamine Z0BIZI Amfetamine Z1SAXE amfetamine ZLFXWZ Amphetamine

Statement of findings for Test Sample 2

Code Amfetamine Caffeine 0DA6JO + ANP De los análisis realizados se concluye que el polvo blanco se trata de anfetamina. 0NNGO4 - -

0YFLNL + + 1 glass bottle containing 0.23 grammes of a powder containing 0.01 grammes of amphetamine. 144FAB + + A white powder containing an average of 7% of amphetamine (calculated as sulphate salt) 192GH2 + + The sample contains amphetamine, caffeine and creatine. 28NZ22 + + The sample contains amfetamine (5.4%) and caffeine. 2EQC6Q + + The sample also contained caffeine. 2UUUXU + ANP After analysing the sample with colourimetric tests, MSD confirmation and subsequent quantification by chromatography with FID detector, we are confident that the SM-2 sample contains 6.52 % amphetamine base. caffeine is detected too. 3DVBVE + +

3LN2N9 + + contained amfetamine and coffeine 44VN4T + + d,l-amphetamine (salt form not determined), caffeine, and creatine confirmed in one unit tested of one unit recieved. 4CVIID + + In the test sample 2013/2/SM-2 were detected amfetamine and caffeine 4Y4BMB + + caffeine as adulterant 5AKBA5 + + caffeine, creatine 5DMOWW + - Find also caffeine 29.7% 5OHSAB + +

Code Amfetamine Caffeine 5V2K55 + -

66P66H + + caffeina 6AAAIA + + Illegal substances on the basis of the italian law DPR 309/90 7JPM7K + ANP

7NMYY7 + +

815B51 + + LA MUESTRA DE POLVO BLANCO ES UNA MEZCLA DE ANFETAMINA Y CAFEINA 9999JM + + Sample contains 5.85 ± 0.47 w/w amphetamin base. The sample also contain caffeine and creatinine. 9AT7DN + + It was also detected caffeine, usually found as adulterant in amfetamine' seizures 9S9R99 + + we found amphetamine in SM-2 as controlled drugs and we also found caffein in SM-2 as adulterant A4DVDD + + The sample 2013/2/SM-2 contains Amfetamine and Caffeine detected by GC-MS. The percentage by weight of Amfetamine is 5.8%. AC6AA0 + + Amphetamine was identified by TLC and GC/MS Caffeine was also Identified by TLC and GC/MS ARRBBM + +

AXAVAA + +

B11A58 + + The powder contains amphétamine with caféine and creatine BR66FX + + The sample contains amphetamine and caffeine. The percentage by weight of amphetamine (as base) is 6.2% C6UZN1 + + caffeine, creatine monohydrate CFILQS + + sample 2 contains amfetamine sulfate (5.5 % as base) cut with caffeine (29.0 %) and creatine

Code Amfetamine Caffeine CITDQT + + Also detected Creatinine and Caffeine. No quantitation performed. CMQISC + +

CPCFME + + On analysis, I found the sample to contain amphetamine. DFLETW + +

DGEIFI + + This powder contained an average of 5% AMPHETAMINE together with the adulterants caffeine and creatine monohydrate. DWGQZS + + caféine E4AF6Q + + Amphetamine and Caffein E5B6AC + + Marquis reagent have been apllied, TLC (Thin Layer Chromatography) for opiaces, cocaine and the GC/FID EOZOOO + + Based on the above analysis, the sample was found to contain amphetamine and caffeine. G7GGCR + + caffein GGWXWW + ANP The powder was analysed and found to contain Amphetamine. GULHNN + + On analysis, I found the substance to contain 5.0% of Amphetamine. GZDUQM + + Sample 2013/2/SM-2 consists of white powder. Amfetamine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. The seizure also contains caffeine and lactose. HBHUNI + + Powder containing Amfetamine with cafeine as cutting agent HE2TG2 + + Presence of Sulfates HHHHU5 + + Test Sample 2013/2/SM-2 - one vial containing off-white powder. This powder contained an average of 5% AMPHETAMINE, together with the adulterant caffeine.

Code Amfetamine Caffeine HHRTHH + + SM2 contain Amphetamine. Caffeine was detected also. HVXZXL + + Amfetamine and caffeine detected in SM-2.Amfetamine content is 6.31%. HWGQ3X + + Color Test: Marquis'--> orange then change to brown, Simon --> pink to cherry-red TLC and GCMS: Amphetamine, Caffeine GC: Amphetamine base 5.64%, Caffeine 28.06% I5IP07 + + AMPHETAMINE , CAFEINE IAWA6A + + caffeine IBOQKX + + This sample is amphetamine. II8JO4 + + Powder was found to contain amphetamine at a concentration of less than 5%. Amphetamine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class B drug. IP12QF + + The sample is a preparation that contains amphetamine. JDDD6D + + The test sample 2013/2/SM-2 was analysed by colour test and Thin layer Chromatography techniques and found to contain Amfetamine and Caffeine. JJRRVN + ANP The sample was found to contain amfetamine JKBKRK + ANP 0.238grams of a powder containing 5% Amfetamine. Amfetamine is a Class B controlled drug under the provisions of the Misuse of Drugs Act 1971. JPIPOT + + The sample SM2 contained 5.1 % calculated as a base. In the sample was identified caffeine and creatine. JRLS5J + + The sample contains amfetamine which is scheduled as illicit drug in France. Caffeine and creatine are cutting agent. JSHHOS + + The powder was analysed and found to contain amphetamine. JSZMHJ + + Base Anfetamina 6,97% ,Caffeine and Creatine hydrate JYDFMU + + caffeine, creatine

Code Amfetamine Caffeine KKQS2K + + caffein LLCQXL + + On analysis, I found the substance to contain Amphetamine and caffeine. Quantitative analysis was not carried out to determine the weight of the amphetamine drug. LQEYRY + +

N0TYZE - +

NBNVJG + + CAFEINA NNVNSC + + amfetamine with caffeine and creatine NRVAVR + + The sample 2013/2/SM-2 was found to contain Amfetamine and caffeine. NVUXXR + + Narcotics: Amphetamine (II) (the number refers to legislation) Concentration: 8 % amphetamine sulphate Amount: 0,2 gram NZMVTG + + The sample was found to contain amphetamine. O0NJNN - + Test sample 2013/2/SM2 was found to contain caffeine which is a stimulant. ODFBYE + +

OF0Q00 + + The sample contain amphetamine. The sample contain also caffeine OOAION + + - OOIOUO + - Examination revealed the presence of Amphetamine OQ2JQM + -

P04CR4 + + -The sample obtains with the positive result with Marquis reagent. - TLC: The Rf sample obtain with the same Rf Amphetamine Standard. - GC: The Rt sample obtain with the same Rt Amphetamine Standard.

Code Amfetamine Caffeine PCR99G + + the sample also contains caffeine PDMMHM + + CAFFEINE AND CREATINE WERE IDENTIFIED PWYKZQ + + Caffeine QMG6MM + +

QPEFZE + +

QRPRRR + + the presence of drug confirmed by GC-MS and FTIR analysis, the sulphate form of amphetamine confirmed by the anion analysis QXZKSQ + + The sample contains amfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. R21VX8 + + GC MS NPD RBFBBM - +

RRR6HI + + AMPHETAMINE SULFATE (6.1% as base) - CAFFEINE - CREATINE RSNKH3 + + white powder containing amphetamine (6.1%ww) controlled by national law. In addition also caffeine was detected. SL61P0 + + Caffein, Ritalin (Methylphenidate) SLJETI + +

SUA1EC + + caffein, creatin-monohidrát SZT4VF + + sample contains amphetamine hydrochloride (2,28% of amphetamine base) SZVCHI + ANP positive to marquis reagent: orange positive to scott reagent

retention time as our pattern of amfetamine

Code Amfetamine Caffeine T3A33W + + caffeine UBJZMK + + White powder containing Amfetamine at 7.07% and also caffeine. UGGGBT + + the sampke was confirmed by GC ms and also contains caffeine UOBROB + +

UVIZDN + + In this sample contain Tow substance Amphetamine and Caffeine UY78GL + + LA MUESTRA DOS ADEMAS DE ANFETAMINA CONTIENE CAFEINA UYAC2L + + Amfetamine and Caffeine VDZ8NV ANP + Marquis, ácido amalico, solubilidad, UV, FT-IR y HPLC-DAD VWU2B0 + ANP

W4B4QT + + amphetamine + cafeine WABFAA + + amfetamine, caffeine WEEH53 + + white powder containing 6.3%ww of amphetamine WELQMQ + ANP

WLPRZL - + the result of TLC of test sample and reference substance was same as caffeine. the peak of IR of test sample was shown same as caffeine. WLZJLF + + La muestra contiene Cafeina y Anfetamina WM8MGO + + The results of the tests of the SM2 (94) received confirmed that the mentioned sample contains amphetamine but we are not able to give a cuantification result because we can not do it with our gas chromatography-gas spectometer and we have not got a gas chromatography FID which is the suitable analytical technique. The sample 2 also contains caffein as not controlled drug.

Code Amfetamine Caffeine WTCTPT + + Amphetamine is controlled by law (KB 22/01/1998) WUAUUU + + white powder, mixture of the amphetamine, caffeine and creatine WVBNU6 - +

WWWH4N + + SM2 contains also Coffeine and Creatinine X3UUYH + +

X8WVVF + + whitepowder containing 4.9%ww amphetamine. Caffeine is present. XDOWHP + + the powder is a mixture of caffeine and amphetamine. The concentration of the amphetamine in the sample is 5.4% by weight XLL0OS + + coffeine XNSNEU + + Presence of amfetamine sulphate, caffeine and lactose was detected in the sample. XPOMU1 + + ALSO CAFFEINE XSNG6F + + Sample 2013/2/SM-2 was found to contain Amphetamine a Schedule II drug under the United Nation Convention on Psycotropic Substances. The sample was also found to contain Caffeine. XXR4ZM + + Sample 2013/2/SM-2,a creamy white powder, was found to contain amphetamine, a controlled substance under National Law. Y6T66I + - The sample also contains caffeine and creatinine YXMHT9 + + caffeine, creatine YXXRY9 + + White powder containing Amphetamine and Caffeine Z0BIZI + + Diluted with Caffeine Z1SAXE + + found amfetamine 6.1%ww and caffeine

Code Amfetamine Caffeine ZLFXWZ + + On analysis, I found the substance to contain Amphetamine

Identification methods for Test Sample 2

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 2 The response summary of all 130 participating laboratories for the identification of SM-2, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 2:

Response Summary Participants: 131

Amfetamine: 124 Caffeine: 116

False positives for Test Sample 2

Code Name Technique 5OHSAB Metamfetamine 180/190 5V2K55 Ketamine 180 DWGQZS Ethylamphetamine 180/190 5OHSAB Benzenethanamine 180/190 5OHSAB N-Methyl; N-acetylamphetamine 180/190 SL61P0 Methylphenidate 180

False negatives for SM-2 (techinque(s) used or ANP)

Code: 0NNGO4(180) N0TYZE (180), O0NJNN (180), RBFBBM (180/231

WLPRZL (150/190), WVBNUS (180), VDZ8NV( ANP)

Frequency of use of screening and identification techniques: Response Summary Response Participants: Summary 130 Participants: 131 Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 Screening 43 54 39 16 0 2 0 2 41 8 1 0 0 0 6 32.8% 41.2% 29.8% 12.2% 0.0% 1.5% 0.0% 1.5% 31.3% 6.1% 0.8% 0.0% 0.0% 0.0% 4.6% Identification 12 6 3 30 6 15 3 20 118 70 2 3 2 3 9 9.2% 4.6% 2.3% 22.9% 4.6% 11.5% 2.3% 15.3% 90.1% 53.4% 1.5% 2.3% 1.5% 2.3% 6.9% # labs using 48 54 40 39 6 16 3 21 118 73 3 3 2 3 11 this technique 36.6% 41.2% 30.5% 29.8% 4.6% 12.2% 2.3% 16.0% 90.1% 55.7% 2.3% 2.3% 1.5% 2.3% 8.4%

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 2

Amfetamine Amfetamine CODE MAD: 0.5 CODE MAD: 0.5 Conc. * AbsDev ZScore Conc. * AbsDev ZScore 0YFLNL 5.5 0.1 0.1 JYDFMU 5.4 0.1 0.1 144FAB 5.0 0.5 0.7 LQEYRY 5.1 0.4 0.5 192GH2 46.0 40.5 58.2 NNVNSC 5.4 0.1 0.1 28NZ22 5.4 0.1 0.1 NVUXXR 5.6 0.1 0.2 2EQC6Q 5.5 0.0 0.0 ODFBYE 4.4 1.1 1.5 2UUUXU 6.5 1.1 1.5 OOAION 6.1 0.6 0.9 3DVBVE 5.5 0.1 0.1 P04CR4 10.7 5.2 7.5 3LN2N9 5.2 0.3 0.4 PDMMHM 5.5 0.0 0.0 44VN4T 5.6 0.1 0.2 PWYKZQ 5.8 0.4 0.5 4CVIID 6.2 0.7 1.0 QPEFZE 4.8 0.7 1.0 4Y4BMB 5.6 0.1 0.2 QRPRRR 5.6 0.2 0.2 5AKBA5 5.5 0.0 0.0 QXZKSQ 5.4 0.1 0.1 5DMOWW 2.6 2.9 4.1 RRR6HI 6.2 0.7 1.0 5V2K55 5.1 0.4 0.5 RSNKH3 6.1 0.6 0.9 66P66H 5.0 0.5 0.7 SL61P0 5.3 0.2 0.2 6AAAIA 2.8 2.7 3.8 SZT4VF 2.3 3.2 4.6 7NMYY7 5.1 0.4 0.5 SZVCHI 4.3 1.2 1.8 9999JM 5.9 0.4 0.5 UBJZMK 7.1 1.6 2.3 9AT7DN 5.0 0.4 0.6 WABFAA 5.0 0.5 0.7 A4DVDD 5.9 0.4 0.6 WEEH53 6.3 0.8 1.2 AC6AA0 3.2 2.3 3.3 WELQMQ 6.7 1.2 1.8 AXAVAA 6.0 0.5 0.8 WTCTPT 5.7 0.2 0.3 BR66FX 6.2 0.7 1.0 WUAUUU 5.0 0.5 0.7 CFILQS 5.5 0.0 0.0 WWWH4N 3.9 1.6 2.3 CPCFME 5.6 0.1 0.2 X3UUYH 4.7 0.8 1.1 DFLETW 5.0 0.5 0.7 X8WVVF 4.9 0.6 0.8 DGEIFI 5.0 0.5 0.7 XDOWHP 5.4 0.1 0.1 E4AF6Q 5.7 0.2 0.3 XLL0OS 6.0 0.5 0.8 G7GGCR 4.2 1.3 1.9 XNSNEU 5.5 0.0 0.0 GULHNN 5.0 0.5 0.7 XSNG6F 5.7 0.2 0.3 HHHHU5 5.0 0.5 0.7 XXR4ZM 7.9 2.4 3.5 HHRTHH 21.6 16.1 23.2 Y6T66I 5.3 0.2 0.2 HVXZXL 6.3 0.8 1.2 YXMHT9 6.0 0.5 0.8 HWGQ3X 5.6 0.2 0.2 Z1SAXE 6.1 0.6 0.9 IBOQKX 5.6 0.1 0.2 II8JO4 4.0 1.5 2.1 IP12QF 5.4 0.1 0.1 JKBKRK 5.0 0.5 0.7 JPIPOT 5.1 0.4 0.5 JRLS5J 5.0 0.5 0.7 JSZMHJ 7.0 1.5 2.2

Round: 2013/2 Substance: SM-2/Amfetamine Median = 5.5 MAD = 0.5 UNODC value = 4.9

Sample 3 Analysis

Identified substances for Test Sample 3

Code Identified Substances 0DA6JO MDMA 0NNGO4 1-(3-Chlorophenyl)piperazine 0YFLNL 1-(3-Chlorophenyl)piperazine 144FAB 1-(3-chlorophenyl)piperazine 192GH2 Morfine 28NZ22 1-(3-Chlorophenyl)piperazine 2EQC6Q 1-(3-Chlorophenyl)piperazine 2UUUXU 1-(3-chlorophenyl)piperazine 3DVBVE 1-(3-Chlorophenyl)piperazine 3LN2N9 1-(3-Chlorophenyl)piperazine 44VN4T 1-(3-chlorophenyl)piperazine mono-hydrochloride, morphine, and codeine 4CVIID 1-(3-chlorophenyl)piperazine 4Y4BMB 1-(4-Chlorophenyl)piperazine 5OHSAB 1-(3-CLOROFENIL) PIPERAZINA 5V2K55 1-(3-Clorphenyl)piperazine (mCPP) 66P66H 1-(3-Clorophenyl)piperazine 6AAAIA 1-(3-Chlorophenyl)piperazine 7NMYY7 1-(3-Chlorophenyl)piperazine 815B51 1-(3-CLOROFENIL)PIPERAZINA - MORFINA - CODEINA 9999JM 1-(3-Chlorophenyl)piperazine 9AT7DN 1-(3-chlorophenyl)piperazine 9S9R99 1-(3-chlorophenyl)piperazine A4DVDD 1-(3-Chlorophenyl)piperazine AC6AA0 1-(3-Chlorophenyl)piperazine ARRBBM Piperazine, 1-(3-chlorophenyl-) AXAVAA 1 3 chlorophenyl piperazine BR66FX 1-(3-Chlorophenyl)piperazine C6UZN1 mCPP 1-(3-Chlorophenyl)piperazine CFILQS 1-(3 chlorophényl)pipérazine hydrochloride, morphine CITDQT 1-(3-chlorophenyl) piperazine, Codeine and Morphine. CMQISC 1-(3-Chlorophenyl)piperazine CPCFME 1-(3-Chlorophenyl)piperazine DFLETW 1-(3-Chlorophenyl)piperazine DGEIFI Morphine and 1-(3-chlorophenyl)piperazine DWGQZS m CCP E4AF6Q 1-(3-Chlorophenyl)piperazine E5B6AC HEROINE, m- CPP - HCl, PARACETAMOL, KETAMINE EOZOOO Codeine and morphine G7GGCR 1-(3-Chlorophenyl)piperazine GGWXWW MCPP (1-(3-chlorophenyl)piperazine, Codeine and Morphine.

Code Identified Substances GZDUQM Morphine HBHUNI mCPP HE2TG2 m-CPP, morphine HHHHU5 CHLOROPHENYLPIPERAZINE, MORPHINE, CODEINE HHRTHH m-CPP HVXZXL 1-(3-Chlorophenyl)piperazine/Morphine HWGQ3X 1-(3-Chlorophenyl) piperazine, Morphine,Codeine I5IP07 mCPP ( 1,3 chlorophenylpiperazine) IAWA6A m-CPP IBOQKX mCPP, morphine II8JO4 1-(3-chlorophenyl)piperazine IP12QF m-chlorophenylpiperazine JDDD6D Piperazine JJRRVN 1-(3-chlorophenyl)piperazine JKBKRK 1-(3-chlorophenyl)piperazine JPIPOT m-CPP JRLS5J morphine, 1-(3-Chlorophenyl)piperazine JSHHOS Chlorophenylpiperazine JSZMHJ 1-(3-chlorophenyl)piperazine JYDFMU meta-chlorophenylpiperazine KKQS2K 1-(3-chlorophenyl)piperazine LLCQXL 1-(3-Chlorophenyl)piperazine LQEYRY 1-(3-Chlorophenyl)piperazine, morphine N0TYZE Clorophenylpiperazine NBNVJG 1,3-CLOROFENILPIPERAZINA NNVNSC 1-(3-Chlorophenyl)piperazine NRVAVR 1-(3-Chlorophenyl)piperazine. NVUXXR mCPP NZMVTG mCPP and Morphine O0NJNN 1-(3-Chlorophenyl) piperazine ODFBYE 1-(3-CHLOROPHENYL)PIPERAZINE OF0Q00 m-CPP OOAION 1-(3-Chlorophenyl)piperazine, Morphine OOIOUO 1-(3-Chlorophenyl)piperazine and Codeine PCR99G morphine and codeine PDMMHM 1-(3-CHLOROPHENYL)PIPERAZINE PWYKZQ Morphine and Codeine QMG6MM Morphin; codein; (mCPP) QPEFZE 1-(3-chlorophenyl)piperazine, morphine QRPRRR 1-(3-Chlorophenyl)piperazine hydrochloride R21VX8 1-(3-Chlorophenyl)piperazine RBFBBM 1-(3-Chlorophenyl)piperazine RRR6HI 1,3 CHLOROPHENYLPIPERAZINE RSNKH3 1-(3-chlorophenyl)piperazine and morphine

Code Identified Substances SL61P0 mCPP SLJETI piprazine SUA1EC mCPP(1-(3-clorophenil)-piperazin) SZT4VF 1-(3-chlorphenyl)piperazine SZVCHI not identified T3A33W mCPP UBJZMK 1-(3-Chlorophenyl)piperazine UGGGBT MCPP 1-3 cholorphenyl piperazine UOBROB 1-(3 Clorofenil) Piperazina UVIZDN Morphine UY78GL 1-(3- CLOROFENIL)PIPERAZINA UYAC2L CPP VDZ8NV morfina VWU2B0 morphine W4B4QT 1-(3-clorophenyl)piperazine WABFAA 1,3-chlorophenylpiperazine WELQMQ morphine, mCPP WLPRZL 1-(3-chlorphenyl) piperazine WLZJLF Piperazina WM8MGO 1-(4-clorophenyl)piperazine WTCTPT 1-(3-chlorophenyl)piperazine WUAUUU mCPP WVBNU6 1-3 CLOROFENILPIPERAZINE WWWH4N 1-(3-chlorophenyl)piperazine X3UUYH 1-(3-Chlorophenyl)piperazine X8WVVF 1-(3-clorophenyl)piperazine (m-cpp)) XLL0OS 1-(3-chlorophenyl) piperazine XNSNEU 1-(3-chlorophenyl)piperazine XPOMU1 MORPHINE, 1-(3-CHLOROPHENYL) PIPERAZINE XSNG6F 1-(3-Chlorophenyl)piperazine XXR4ZM 1-(3-Chlorophenyl)piperazine Y6T66I 1-(3-chlorphenyl)piperazine YXMHT9 mCPP HCl (1-(3-chlorophenyl)piperazine HCl) YXXRY9 mCPP, 1-(3-chlorophenyl)piperazine Z0BIZI 1-(3-Chlorophenyl)piperazine Z1SAXE 1-(3-chlorophenyl)piperazine and morphine

Statement of findings for Test Sample 3

Code 1-(3-Chlorophenyl) piperazine 0DA6JO ANP De los análisis realizados se concluye que el polvo blanco se trata de 3,4 metilendioximetanfetamina 0NNGO4 +

0YFLNL + 1 glass bottle containing 0.20 grammes of a powder containing 0.16 grammes of chlorophenylpiperazine, being a compound structurally dervied from 1-phenylpiperazine by substitution in the aromatic ring with haloalkyl substituent. 144FAB + A white powder containing 1-(3-chlorophenyl) piperazine 192GH2 + The sample contains mCPP, codeine and morphine.

28NZ22 + The sample contains 1-(3-Chlorophenyl)piperazine (not quantified). 2EQC6Q +

2UUUXU + After analysing the sample with colourimetric tests, MSD confirmation we are confident that the SM-3 samples is mCPP 1-(3-chlorophenyl)piperazine base. no quantification 3DVBVE +

3LN2N9 + 1-(3-Chlorophenyl)piperazine 44VN4T + 1-(3-chlorophenyl)piperazine mono-hydrochloride, morphine (salt form not determined), and codeine (salt form not determined) confirmed in one unit tested of one unit recieved. 4CVIID + In the test sample 2013/2/SM-3 was detected 1-(3-chlorophenyl)piperazine 4Y4BMB + We found 1-(4-Chlorophenyl)piperazine instead 1-(3-Chlorophenyl)piperazine 5AKBA5 + mCPP 5DMOWW + mCPP chlorophenylpiperazine is not quantified routinely in our laboratory. It's not a controlled drug in France.

Code 1-(3-Chlorophenyl) piperazine 5OHSAB + Was found too CODEINE 5V2K55 +

66P66H + non è stato possibile quantificare perché non abbiamo standard 6AAAIA +

7JPM7K ANP

7NMYY7 +

815B51 + LA MUESTRA DE POLVO BLANCO ES UNA MEZCLA DE 1-(3-CLOROFENIL)PIPERAZINA, MORFINA Y CODEINA; TODAS CONSIDERADAS COMO DROGAS ILEGALES EN MEXICO 9999JM + Sample contains 82.0 ± 3.7 w/w 1-(3-Chlorophenyl)piperazine base in HCL salt form. Trace amount of morphine and codeine were also detected by GC/MS. 9AT7DN + Quantitative results were no reported due to the lack of the appropiate analytical standard. 9S9R99 + We found 1-(3-chlorophenyl)piperazine as uncontrolled drugs A4DVDD + The sample 2013/2/SM-3 contains 1-(3-Chlorophenyl)piperazine detected by GC-MS. The percentage by weight of 1-(3-Chlorophenyl)piperazine is 31.1%. AC6AA0 + 1-(3-Chlorophenyl)piperazine was identified by TLC and GC/MS ARRBBM +

AXAVAA + which is not narcotic in Albania B11A58 + The powder contains M-CPP ( 1-(3-chlorophenyl)piperazine ) M-CPP is not a drug in France BR66FX + The sample contains 1-(3-Chlorophenyl)piperazine. The percentage by weight of1-(3-Chlorophenyl) piperazine (as base) is 84.4%.

Code 1-(3-Chlorophenyl) piperazine C6UZN1 + morphine CFILQS + sample 3 contains 1-(3 chlorophényl)pipérazine hydrochloride (81.5 % as base), morphine and codéine (not quantified) CITDQT + No quantitation performed. CMQISC + morphine, codeine CPCFME + On analysis, I found the sample to contain 1-(3-chlorophenyl)piperazine(also known as mCPP). DFLETW +

DGEIFI + This powder contained 1-(3-CHLOROPHENYL)PIPERAZINE (CPP).

(I would not include in my statement the presence of morphine in the powder as it is at such low levels and I am satisfied in my opinion it is below 0.2% and would therefore not be controlled under the Misuse of Drugs Act 1971). DWGQZS +

E4AF6Q + 1-(3-Chlorophenyl)piperazine E5B6AC + Marquis reagent have been apllied, TLC (Thin Layer Chromatography) for opiaces, cocaine and the GC/FID EOZOOO + Based on the above analysis, the sample was found to contain codeine, morphine and 1-(3- chlorophenyl)piperazine. G7GGCR +

GGWXWW + The powder was analysed and found to contain MCPP (1-(3-chlorophenyl)piperazine, Codeine and Morphine. GULHNN + On analysis, I found the substance to contain 1-(3-Chlorophenyl)piperazine GZDUQM ANP Sample 2013/2/SM-3 consists of white powder. Morphine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. The seizure also contains codeine and paracetamol.

Code 1-(3-Chlorophenyl) piperazine HBHUNI + Powder containig mCPP HE2TG2 + Presence of Chlorides HHHHU5 + Test Sample 2013/2/SM-3 - one vial containing off-white powder. This powder contained CHLOROPHENYLPIPERAZINE, together with MORPHINE and CODEINE.

Note: The morphine and codeine in this powder were present in relatively small amounts when compared to the chlorophenylpiperazine. The amount of morphine and codeine contained in this powder have not been accurately determine as part of this submission. HHRTHH + SM3 contain m-CPP.HCl HVXZXL + 1-(3-Chlorophenyl)piperazine and morphine detected in SM-3.Morphine content is 1.74%. HWGQ3X + Color Test: Marquis, Mecke, Froehde --> negative; Simon --> Blue then slowly change to yellow TLC: 1-(3-Chlorophenyl) piperazine GCMS: 1-(3-Chlorophenyl) piperazine, Morphine,Codeine GC: 1-(3-Chlorophenyl) piperazine base 83.17%, Morphine base 1.54%, Codeine (trace) I5IP07 +

IAWA6A + codein and morphine (contamination) IBOQKX + This sample is mCPP wtih traces of morphine. II8JO4 + Powder was found to contain chlorophenylpiperazine. Chlorophenylpiperazine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class C drug. IP12QF + The sample is a preparation that contains the new phsycoactive drug m-chlorophenylpiperazine JDDD6D + The test sample 2013/2/SM-3 was analysed by colour test and Thin layer Chromatography techniques and found to contain Piperazine. JJRRVN + the sample was found to contain 1-(3-chlorophenyl)piperazine JKBKRK + 0.206grams of a powder containing Chlorophenylpiperazine. Chlorophenylpiperazine is a Class C drug under the provisions of the Misuse of Drugs Act 1971.

Code 1-(3-Chlorophenyl) piperazine JPIPOT + The sample SM3 contained 80.1 % calculated as a base. JRLS5J + The sample contains morphine and codeine which are scheduled as illicit drugs in France. 1-(3- Chlorophenyl)piperazine is not scheduled as illicit drug in France. JSHHOS + The powder was analysed and found to contain amphetamine. JSZMHJ + 1-(3-chlorophenyl)piperazine hidrochloride JYDFMU +

KKQS2K +

LLCQXL + On analysis, I found the substance to contain 1-(3-Chlorophenyl) piperazine. LQEYRY + We also found traces (very small amount) of codein N0TYZE +

NBNVJG +

NNVNSC + 1-(3-Chlorophenyl)piperazine NRVAVR + The sample 2013/2/SM-3 was found 1-(3-Chlorophenyl)Piperazine. NVUXXR + Identified substance: mCPP Amount: 0,2 gram The substance identified is whit it´s chemical structure a piperazine NZMVTG + The sample was found to contain 1-(3-chlorophenyl)piperazine and morphine (trace amounts). O0NJNN + Test sample 2013/2/SM3 was found to contain 1-(3-Chlorophenyl) piperazine which is a controlled drug. ODFBYE +

Code 1-(3-Chlorophenyl) piperazine OF0Q00 + The sample contain a piperazine derived designer drug 1-(3-chlorophenyl)-piperazine. OOAION + - OOIOUO + Examination revealed the presence of piperazine and Codeine OQ2JQM +

P04CR4 ANP

PCR99G + the sample also contains 1-3(chlorophenyl) piperazine PDMMHM + TRACES OF TFMPP, MORPHINE AND CODEINE WERE IDENTIFIED PWYKZQ + 1-(3-Cholorophenyl)piperazine QMG6MM + mCPP : is not considerated as a drug in France . QPEFZE +

QRPRRR + the presence of drug confirmed by GC-MS and FTIR analysis, the hydrochloride form confirmed by the anion analysis QXZKSQ + The analysis did not reveal any controlled drug according to french order, decree of February 22nd 1990. R21VX8 + GC MS (NO STANDARD BASED ON LIBRARY) RBFBBM +

RRR6HI + 1,3 CHLOROPHENYLPIPERAZINE CHLORYDRATE (84,8% as base) RSNKH3 + White powder containing morphine (2.1%ww) and mCPP, which are controlled drugs. The amount of mCPP was not determined because the lack of reference material. In addition was detected codeine.

Code 1-(3-Chlorophenyl) piperazine SL61P0 +

SLJETI +

SUA1EC + morphin, codeine (contamination) SZT4VF + sample contains 1-(3-chlorphenyl)piperazine SZVCHI ANP positive to marquis reagent: violet. retention time unknown T3A33W + The sample contain trace morphine and codeine UBJZMK + White powder containing 1-(3-Chlorophenyl)piperazine at 59.63% UGGGBT + the sample was confirmed by GC MS and laso contains trace of caffeine UOBROB +

UVIZDN + In this sample contain tow substance Morphine and MCPP(piprazin) UY78GL + EL ANALISIS POR CROMATOGRAFIA GC/MZ DIO COMO RESULTADO QUE LA MUESTRA CONTIENE 1-(3- CLOROFENIL)PIPERAZINA UYAC2L + 1-(3-Chlorophenyl)piperazine VDZ8NV ANP Se le realizó pruebas de marquis, scott, HPLC-dad, FT-IR, UV VWU2B0 ANP

W4B4QT + 1-(3-clorophenyl)piperazine WABFAA + 1,3-chlorophenylpiperazine WEEH53 + white powder containing 1-(3-chlorophenyl)piperazine (mcpp) potential hazard substance

Code 1-(3-Chlorophenyl) piperazine WELQMQ +

WLPRZL + the peak of IR of test sample was same as 1-(3-chlorphenyl) piperazine WLZJLF +

WM8MGO - The results of the tests of the SM3 (81) received confirmed that the mentioned sample contains 1(4 chlorophenyl)piperazine but this is a not controlled substance yet WTCTPT + 1-(3-chlorophenyl)piperazine is controlled by law (KB 22/01/1998 changed by KB 22/10/2006) WUAUUU + white powder, no other compound WVBNU6 +

WWWH4N + SM3 contanis also trace amount of Morphine and Codeine X3UUYH +

X8WVVF + white powder containing m-cpp (not quantified) XDOWHP + the powder contains 1-(3-chlorophenyl)piperazine also known as mCPP. It also contains a very little amount of codeine (traces) XLL0OS +

XNSNEU + Presence of 1-(3-chlorophenyl)piperazine hydrochloride was detected in the sample. XPOMU1 + ALSO CODEINE XSNG6F + Sample 2013/2/SM-3 was found to contain 1-(3-Chlorophenyl)piperazine not scheduled under the Single Convention on Narcotic Drugs or the United Nation Convention on Psycotropic Substances. XXR4ZM + Sample 2013/2/SM-3,a white,flaky, odorless powder, was found to contain CPP [1-(3- Chlorophenyl)piperazine], a controlled substance under National Law.

Code 1-(3-Chlorophenyl) piperazine Y6T66I +

YXMHT9 + mCPP HCl - not under control in Polish law YXXRY9 + Off-white powder containing mCPP and traces of Morphine and Codeine Z0BIZI +

Z1SAXE + found 1-(3-chlorophenyl)piperazine (mcpp) 96.2%ww , morphine 2.2%ww , and codeine. ZLFXWZ + On analysis, I found the substance to contain 1-(3-chrorophenyl)piperazine.

Identification methods for Test Sample 3

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 3 The response summary of all 130 participating laboratories for the identification of SM-3, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 3:

Response Summary Participants: 131

1-(3-Chlorophenyl)piperazine: 123

False positives for Test Sample 3

Code Name Technique 0DA6JO MDMA 190/210 E5B6AC Ketamine, Heroin, Paracetamol 150/171 JSHHOS Amphetamine 180/190 PDMMHM TFMPP 180/161 GZDUQM Paracetamol 170

False negatives for SM-3 (techinque(s) used or ANP)

Code: WM8MGO (180/141) 0DA6J0 (ANP), 7JPM7K (ANP), GZZDUQM (ANP)

P04CR4 (ANP), SZVCHI (ANP), VDZ8NV (ANP), VWU2BO (ANP)

Frequency of use of screening and identification techniques: Response Summary ResponseResponse Participants: Summary Summary 130 Participants: 131 Participants: 131 140 141 142 150 160 161 170 171 211 230 Section 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 Screening 43 54 39 16 0 2 0 2 41 8 1 0 0 0 6 32.8% 41.2% 29.8% 12.2% 0.0% 1.5% 0.0% 1.5% 31.3% 6.1% 0.8% 0.0% 0.0% 0.0% 4.6% Identification 12 6 3 30 6 15 3 20 118 70 2 3 2 3 9 9.2% 4.6% 2.3% 22.9% 4.6% 11.5% 2.3% 15.3% 90.1% 53.4% 1.5% 2.3% 1.5% 2.3% 6.9% # labs using 48 54 40 39 6 16 3 21 118 73 3 3 2 3 11 this technique 36.6% 41.2% 30.5% 29.8% 4.6% 12.2% 2.3% 16.0% 90.1% 55.7% 2.3% 2.3% 1.5% 2.3% 8.4%

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 3

1-(3-Chlorophenyl) piperazine CODE MAD: 2.3 Conc. * AbsDev ZScore 0YFLNL 80.5 2.0 0.6 2EQC6Q 80.5 2.0 0.6 3DVBVE 80.8 1.7 0.5 3LN2N9 84.2 1.7 0.5 44VN4T 79.6 2.9 0.9 4CVIID 82.0 0.5 0.1 5V2K55 83.3 0.8 0.2 9999JM 82.0 0.5 0.1 A4DVDD 31.1 51.4 15.1 AC6AA0 82.7 0.2 0.1 BR66FX 84.4 1.9 0.6 CFILQS 81.5 1.0 0.3 DFLETW 82.5 0.0 0.0 HHRTHH 85.6 3.1 0.9 HWGQ3X 83.2 0.7 0.2 IBOQKX 85.4 2.9 0.9 JPIPOT 80.1 2.4 0.7 JYDFMU 100.0 17.5 5.1 LQEYRY 98.3 15.8 4.6 NNVNSC 80.4 2.1 0.6 OOAION 74.4 8.2 2.4 QPEFZE 53.0 29.5 8.7 QRPRRR 83.5 1.0 0.3 RBFBBM 83.0 0.5 0.1 RRR6HI 84.8 2.3 0.7 UBJZMK 59.6 22.9 6.7 WABFAA 95.0 12.5 3.7 WELQMQ 90.3 7.8 2.3 WLPRZL 96.8 14.3 4.2 WTCTPT 80.5 2.0 0.6 WUAUUU 76.0 6.5 1.9 WWWH4N 79.8 2.7 0.8 X3UUYH 83.8 1.3 0.4 XLL0OS 73.1 9.4 2.8 XNSNEU 77.5 5.0 1.5 Y6T66I 82.5 0.0 0.0 Z1SAXE 96.2 13.7 4.0

*) Concentration: w/w %

Round: 2013/2 Substance: SM-3/1-(3-Chlorophenyl)piperazine Median = 82.5 MAD = 2.3 UNODC value = 82.1

Sample 4 Analysis

Identified substances for Test Sample 4

Code Identified Substances 0NNGO4 Lactose 9AT7DN None 9S9R99 - E4AF6Q None EOZOOO None HE2TG2 Lactose HHRTHH BLANK HVXZXL Lactose HWGQ3X None II8JO4 None JDDD6D Lactose Monohydrate JJRRVN lactose JPIPOT Lactose JRLS5J lactose NZMVTG No common controlled drugs O0NJNN None OF0Q00 Amphetamine OOAION - QMG6MM No drug RBFBBM no drugs RRR6HI LACTOSE SLJETI spice (oleamide) SZT4VF / SZVCHI none UGGGBT not detected for drugs UVIZDN No controlled drugs UY78GL NA UYAC2L - W4B4QT NOT drugs found WABFAA - WLPRZL Lactose WM8MGO NONE WVBNU6 LACTOSA

Statement of findings for Test Sample 4

Code Lactose 0DA6JO + De los análisis realizados se concluye que el polvo blanco se trata de lactosa. 0NNGO4 +

0YFLNL + 1 glass bottle containing 0.23 grammes of a powder which did not contain any substances controlled under the Dangerous Drugs Ordinance (Cap.134). 144FAB + A white powder containing lactose 192GH2 + The sample is lactose. 28NZ22 - No controlled drugs detected. 2EQC6Q + The sample contained lactose. 2UUUXU ANP After analysing the sample with colourimetric tests, MSD chromatography (several methods) we are confident that SM-4 sample is not drugs-negative 3DVBVE +

3LN2N9 ANP not detected substances by method GC/MS 44VN4T + Lactose confirmed in one unit tested of one unit recieved. 4CVIID + In the test sample 2013/2/SM-4 was detected lactose 4Y4BMB + Lactose 5AKBA5 + Lactose 5DMOWW + Ose 5OHSAB + LACTOSA,4-TETRAMETHYLENEAZIRIDINE

Code Lactose 5V2K55 ANP

66P66H + lattosio 6AAAIA +

7JPM7K ANP

7NMYY7 -

815B51 + LA MUESTRA DE POLVO BLANCO CORRESPONDE A LACTOSA 9999JM + The sample contains lactose. 9AT7DN + Lactose, usual diluent, was found in this sample 9S9R99 + We found alpha-lactose monohydrate in SM-4 A4DVDD + The sample 2013/2/SM-4 does not contain any drug in the menu of ICE programme. AC6AA0 + Lactose was identified by TLC ARRBBM ANP

AXAVAA ANP

B11A58 + the powder contains lactose BR66FX + The sample contains lactose. C6UZN1 + lactose CFILQS + sample 4 contains lactose

Code Lactose CITDQT -

CMQISC +

CPCFME ANP On analysis of the sample, no controlled drugs were detected. DFLETW +

DGEIFI + No controlled drugs were detected in this powder, which contained lactose. DWGQZS + Lactose E4AF6Q + Lactose E5B6AC + Marquis reagent have been apllied, TLC (Thin Layer Chromatography) for opiaces, cocaine and the GC/FID EOZOOO + Based on the above analysis, the sample was found to contain lactose. G7GGCR + lactose GGWXWW ANP The powder was analysed for the presence of drugs controlled within the provisions of the Misuse of Drugs Act 1971 with a negative result. GULHNN + On analysis, I found the substance to contain lactose GZDUQM + Sample 2013/2/SM-4 consists of white powder. No prohibited substances included in the National Law for Narcotics, are found to be present in this sample. The sample contains paracetamol and lactose. HBHUNI ANP

HE2TG2 +

HHHHU5 + Test Sample 2013/2/SM-4 - one vial containing white powder. No controlled drugs were detected in this powder which contained lactose.

Code Lactose HHRTHH - SM4 was free of drugs HVXZXL + Lactose detected in SM-4. HWGQ3X + Color test: negative TLC and GCMS: drug not found GC: no peak FT-IR: Lactose I5IP07 + LACTOSE IAWA6A + lactose IBOQKX + This sample is lactose. II8JO4 + No controlled drugs detected. Results indicated the powder to be lactose. IP12QF + It is detected the presence of lactose in the sample. JDDD6D + The test sample 2013/2/SM-4 was analysed by colour test and Thin layer Chromatography techniques and found to contain Lactose Monohydrate. JJRRVN + the sample was found to contain lactose JKBKRK + No controlled drugs were detected. JPIPOT + The sample SM4 contained lactose. JRLS5J + The lactose is not scheduled as illlicit drug in France, it's a cutting agent. JSHHOS + The powder was analysed and found to contain no controlled substances. JSZMHJ + Lactose JYDFMU + lactose 100%

Code Lactose KKQS2K ANP

LLCQXL ANP On analysis, I did not detect drug in "2013/2/SM-4" sample. LQEYRY + We only found lactose N0TYZE -

NBNVJG + LACTOSA NNVNSC + lactose NRVAVR ANP The sample 2013/2/SM-4 did not contain any of the drugs tested for. NVUXXR + Possibly sugar Amount: 0,2 gram NZMVTG + The sample was found to contain no common controlled drugs. O0NJNN - Controlled drugs were not detected in test sample 2013/2/SM4. ODFBYE -

OF0Q00 ANP The sample contain amphetamine. OOAION ANP - OOIOUO ANP None detected OQ2JQM ANP

P04CR4 ANP

PCR99G + the sample contains lactose

Code Lactose PDMMHM + LACTOSE WAS IDENTIFIED PWYKZQ ANP negative QMG6MM +

QPEFZE + SM-4 contains lactose QRPRRR +

QXZKSQ + The analysis did not reveal any controlled drug according to french order, decree of February 22nd 1990. R21VX8 + LACTOSE POSITIVE RBFBBM + Lactose RRR6HI + LACTOSE RSNKH3 ANP

SL61P0 -

SLJETI ANP

SUA1EC + lactose SZT4VF + sample contains lactose SZVCHI ANP negative to marquis reagent negative to scott reagent there is not signal in our chromatogram T3A33W + lactose UBJZMK + White powder containing lactose, NO illegal drugs where detected.

Code Lactose UGGGBT ANP the sample was performed by TLC , UV and GC MS and no illicit or psycotric drugs were found neither UOBROB +

UVIZDN + We find in this Sample Lactose UY78GL + DE ACUERDO AL ESPECTRO IR LA MUESTRA CORRESPONDE A LACTOSA UYAC2L + Lactose VDZ8NV + se le realizó marquis, scott, chen cao, lieberman y FT-IR VWU2B0 ANP

W4B4QT + NOt identified any regulated substance, we identified Lactose WABFAA - - WEEH53 ANP

WELQMQ ANP

WLPRZL + The result of TLC and IR of test sample was same as Lactose WLZJLF - La muestra es Lactosa WM8MGO - we have not found any controlled drug in the SM 4 WTCTPT ANP Samples contains lactose (screening with FT-IR) WUAUUU + white powder identified as lactose WVBNU6 +

Code Lactose WWWH4N + SM4 contains Lactose X3UUYH ANP

X8WVVF + white powder containing lactose XDOWHP + powder containing lactose. XLL0OS + lactose XNSNEU + Presence of lactose was detected in the sample. XPOMU1 ANP

XSNG6F +

XXR4ZM ANP Sample 2013/2/SM-4,a white odorless powder, was not found to contain any controlled substance under National Law. Y6T66I + The sample contains lactose YXMHT9 + lactose YXXRY9 ANP White powder, negative Z0BIZI + Lactose Z1SAXE ANP

ZLFXWZ + On analysis, I found the substance to contain Lactose

Identification methods for Test Sample 4

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 4 The response summary of all 130 participating laboratories for the identification of SM-4, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 4:

Response Summary Participants: 131

Lactose: 89

False positives for Test Sample 4

Code Name Technique OF0Q00 Amfetamine 190 (ASAP-TOF MS) GZDUQM Paracetamol (Acetaminophen) 170

Frequency of use of screening and identification techniques: ResponseResponse Summary Summary Participants:Response Participants: Summary 131 130 SectionParticipants:Section 131140 140 141 141142 142 150 150 160 161 170 171 180 190 200 211 230 231 210 Screening 43 54 39 16 0 2 0 2 41 8 1 0 0 0 6 32.8% 41.2% 29.8% 12.2% 0.0% 1.5% 0.0% 1.5% 31.3% 6.1% 0.8% 0.0% 0.0% 0.0% 4.6% Identification 12 6 3 30 6 15 3 20 118 70 2 3 2 3 9 9.2% 4.6% 2.3% 22.9% 4.6% 11.5% 2.3% 15.3% 90.1% 53.4% 1.5% 2.3% 1.5% 2.3% 6.9% # labs using 48 54 40 39 6 16 3 21 118 73 3 3 2 3 11 this technique 36.6% 41.2% 30.5% 29.8% 4.6% 12.2% 2.3% 16.0% 90.1% 55.7% 2.3% 2.3% 1.5% 2.3% 8.4%

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

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