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The Program of the Workshop The Program of the Workshop Wednesday, 14 December 2016 9.00 – 9.30 OPENING CEREMONY Session A. Chairpersons: Prof. Stefka Valcheva-Kuzmanova, MD, PhD, DSc Medical University, Varna Assoc. Prof. Radostina Alexandrova, MSc, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Tanya Zhivkova, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences 9.30 – 10.00 AO1. HUMAN MICROBIОME AND APPROACHES FOR INFLUENCING Tsvetelina Velikova University Hospital St. Ivan Rilski, Laboratory of clinical immunology 10.00 – 10.30 AO2. PLANT GENOTYPE DIVERSITY INDUCED BY STRESSED ENVIRONMENT – A WAY TOWARDS ADAPTATION OR EXTINCTION? Borislava Kukurina and George Miloshev Laboratory of Molecular Genetics, Institute of Molecular Biology, BAS 10.30 – 11.00 AO3. CYTOTOXIC ACTIVITY OF NON-STEROIDAL ANTI- INFLAMMATORY AGENTS, BILE ACIDS AND THEIR METAL COMPLEXES Lora Dyakova, Gabriela Marinescu, Milena Georgieva, Tanya Zhivkova, George Miloshev, Daniela-Cristina Culita, Marin Alexandrov, Luminita Patron. Radostina Alexandrova 11.00 – 11.20 Coffee Break 11.20 – 11.35 1 AO4. MACROSCOPIC EVALUATION OF THE PROTECTIVE EFFECT OF ARONIA MELANOCARPA FRUIT JUICE IN A MODEL OF TRINITROBENZENESULFONIC ACID-INDUCED COLITIS IN RATS S. Valcheva-Kuzmanova1, M. Zhelyazkova1, M. Eftimov1, V. Marinov1, M. Tzaneva2 1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 11.35 – 12.05 AO5. BIOCHEMICAL EVALUATION OF THE EFFECT OF ARONIA MELANOCARPA FRUIT JUICE IN A MODEL OF TRINITROBENZENESULFONIC ACID-INDUCED COLITIS IN RATS A. Kuzmanov1, V. Kuzmanova1, S. Valcheva-Kuzmanova2 1Student, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 2Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 12.05-12.20 AO6. STUDY ON THE EFFECTS OF ALKALINE EARTH METALS ON THE ACTIVITY OF AMINOPEPTIDASE A IN NORMAL AND TUMOR HUMMAN MAMMARY GLAND-DERIVED CELLS V. Petrova1, V. Pavlova1, I. Iliev1, V. Lozanov2, I. Ivanov2, M. Dimitrova1 1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria 2Department of Chemistry and Biochemistry, Faculty of Medicine, Medical University –Sofia, Bulgaria 12.20 – 12.35 Discussion 12.35-12.50 Lunch time 2 Session B. Chairpersons: Prof. Ivo Grabchev, MSc, PhD, DSc Faculty of Medicine, Sofia University “St. Kliment Ohridski” Assoc. Prof. Radostina Alexandrova, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Lora Dyakova, MSc Institute of Neurobiology, Bulgarian Academy of Sciences 13.45 – 14.00 BO1. MACROSCOPIC EVALUATION OF THE EFFECT OF ANETHOLE IN A MODEL OF TRINITROBENZENESULFONIC ACID- INDUCED COLITIS IN RATS S. Valcheva-Kuzmanova1, M. Zhelyazkova1, M. Eftimov1, V. Marinov1, M. Tzaneva2 1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 14.00 – 14.30 BO2. S. Valcheva-Kuzmanova 1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, Varna, Bulgaria 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 14.30-15.00 BO3. BIOACTIVE COMPOUNDS ISOLATED FROM GARDEN SNAILS Pavlina Dolashka1, Aleksander Dolashki1, Lyudmila Velkova1, Stefan Stevanovic2, Laura Molin3, Pietro Traldi3 Radostina Velikova1 and Wolfgang Voelter4 1 Institute of Organic Chemistry; 2 Institute for Cell Biology, Department of Immunology, University of Tübingen, Germany; 3 R-ISTM, Padova, Italy; 4 Interfacultary Institute of Biochemistry, University of Tϋbingen, Germany 15.00-15.15 3 BO4. N- LINKED CARBOHYDRATE STRUCTURES OF MOLLUSCAN HEMOCYANINS FROM SNAILS Lyudmila Velkova1, Aleksandar Dolashki1, Pavlina Dolashka1 1Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria 15.15 – 15.35 Coffee Break 15.35-16.05 B05. MICROBIOLOGICAL ACTIVITY OF Cu(II) AND Zn(II) COMPLEXES OF A NEW BENZANTHRONE TRIPOD D. Staneva1, S. Grabchev2, E. Nikolova2, E. Vasileva-Tonkova3, P. Bosch4, I. Grabchev5 1University of Chemical Technology and Metallurgy, Sofia, Bulgaria 2Sofia University “St. Kliment Ohridski”, Faculty of Chemistry and Pharmacy, Sofia, Bulgaria 3Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria 4Institute of Science and Technology of Polymers, CSIC, Madrid, Spain 5Sofia University “St. Kliment Ohridski”, Faculty of Medicine, Sofia, Bulgaria 16.05 – 16.20 BO6. ACTIVITY OF WATER EXTRACT FROM NEPETA NUDA L. AGAINST ACV-RESISTANT HUMAN HERPES VIRUS TYPE 2 Petia Angelova1, Anton Hinkov1, Venelin Tsvetkov1 , Kalina Shishkova1 ,Daniela Dragolova2, Veneta Kapchina-Toteva2, Stoyan Shishkov1 1 - Laboratory of Virology, Faculty of Biology, University of Sofia ‘‘St. Kl. Ohridski’’, Sofia, Bulgaria 2 - Department of Plant physiology, Faculty of Biology, University of Sofia “St. Kl. Ohridski”, Sofia, Bulgaria 16.20 – 16.35 Discussion 4 Wednesday, 15 December 2016 Session C. Chairpersons: Assoc. Prof. Julia Radenkova-Saeva, MD, PhD Clinic of Toxicology, Department for Adult, Emergency University Hospital “N.I.Pirogov” Assoc. Prof. Radostina Alexandrova, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Boyka Andonova-Lilova, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences 9.00-9.30 CO1. TRACKING RESISTANCE OF COMBINATIONS OF PROBIOTIC BACTERIA IN MODEL CONDITIONS OF DIGESTION INCLUDED IN GEL OF CHITOSAN Iliana Nacheva, Aleksandar Valchkov, Kamelia Loginovska, Daniela Mitеva Institute of Cryobiology and Food Technologies, Sofiaq Bulgaria 9.30-10.00 CO2. USAGE EVALUATION OF ZINC INORGANIC COMPOUNDS AND ZINC ORGANIC COMPLEXES (CHELATES) IN REGARD TO THEIR FAVOURABLE PROSPECTS, INVOLVING OVERDOSE BIOASSAYS ON CHICKENS Sofiya Ivanova1, Katerina Todorova2, Margarita Marinova1, Petar Stamberov3, 1 2 Georgi Kalistratov , Russy Russev 1 National Diagnostic and Research Veterinary Medical Institute, Sofia, Bulgaria 2Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria 3 University of Forestry, Sofia, Bulgaria 10.00 – 10.30 CO3. LYOPHILISED MEAT FOODS DEVELOPMENT FOR SPECIALIZED NUTRITION HAVING RADIOPROTECTIVE EFFECT Daniela Miteva1, Plamen Petrunov2, Iliana Nacheva1, K. Dimov1, A. Valchkov1 Institute of Cryobiology and Food Technologies1, Sofia Military Medical Academy2, Sofia, Bulgaria 5 10.30 – 11.00 CO4. "SACRED PLANTS" WITH PSYCHOACTIVE PROPERTIES Radenkova-Saeva J. Toxicology Clinic, UMHATEM “N.I.Pirogov”, Sofia, Bulgaria 11.00 – 11.20 Coffee Break 11.20 – 11.50 CO5. Pencho Beykov Boykov Faculty of Chemistry and Pharmacy, Sofia University St. “Kl. Ohridski” 11.50 – 12.05 CO6. Консумация на алкохол и окислително увреждане на ДНК. Мария Минчева и Катя Попова 12.05 – 12.30 Discussion 12.30 – 13.45 Lunch time 13.45-14.00 CO7. ZINK IN THE ETIOLOGY OF ACRODERMATITIS ENTEROPATHICA Liliya Lazova, Vasil Boyanov Medical University of Sofia 14.00 – 14.15 CO8. TOPICAL IMMUNOTHERAPTY TREATING ALOPECIA Vasil Boyanov, Liliya Lazova Medical University of Sofia 14.15 – 14.30 CO9. SILYMARIN AND LIVER Liliya Lazova, Vasil Boyanov Medical University of Sofia 6 Friday, 16 December 2016 Session D. Chairpersons: Assoc. Prof. Anna Tolekova, MD, PhD Medical Faculty, Trakia University, Stara Zagora, Bulgaria Assoc. Prof. Radostina Alexandrova, MSc. PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Desislav Dinev, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences 9.00 – 9.30 DO1. Boyka Andonova-Lilova, Radostina Alexandrova Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria 9.30 – 10.00 DO2. INFLUENCE OF THE REACTION MEDIUM ON THE CHEMICAL, PHASE AND MORPHOLOGICAL CHARACTERISTICS OF DOUBLE-DOPED AMORPHOUS CALCIUM PHOSPHATES K. Sezanova, R. Gergulova, D. Rabadjieva, S. Tepavitcharova, R. Ilieva Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria 10.00-10.15 DO3. RAT BLOOD BIOCHEMICAL MARKERS TESTED AFTER CALVARIA IMPLANTATION WITH ION-MODIFIED CALCIUM PHOSPHATE BIOMATERIALS Kostadinka Sazanova2, Marin Alexandrov1, Veselin Nanev1, Neli Tsocheva-Gaytandzhieva1, Ivelin Vladov1, Petar Dimitrov1, Margarita Gabrashanska1 1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria 2Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria 7 10.15 – 10.30 DO4. SYNTESIS AND CHARACTERIZATION OF NEW DOUBLE QUATERNARY POLYMERS AND THEIR HYDROGELS AS BIOMATERIALS WITH POTENTIAL ANTIMICROBIAL APPLICATIONS Denitsa Nikolova1, Konstans Ruseva1, Stephan Metsov2, Elena
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