The Program of the Workshop

Wednesday, 14 December 2016

9.00 – 9.30 OPENING CEREMONY

Session A.

Chairpersons: Prof. Stefka Valcheva-Kuzmanova, MD, PhD, DSc Medical University, Varna Assoc. Prof. Radostina Alexandrova, MSc, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Tanya Zhivkova, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

9.30 – 10.00 AO1. HUMAN MICROBIОME AND APPROACHES FOR INFLUENCING

Tsvetelina Velikova

University Hospital St. Ivan Rilski, Laboratory of clinical immunology

10.00 – 10.30 AO2. PLANT GENOTYPE DIVERSITY INDUCED BY STRESSED ENVIRONMENT – A WAY TOWARDS ADAPTATION OR EXTINCTION? Borislava Kukurina and George Miloshev

Laboratory of Molecular Genetics, Institute of Molecular Biology, BAS

10.30 – 11.00 AO3. CYTOTOXIC ACTIVITY OF NON-STEROIDAL ANTI- INFLAMMATORY AGENTS, BILE ACIDS AND THEIR METAL COMPLEXES Lora Dyakova, Gabriela Marinescu, Milena Georgieva, Tanya Zhivkova, George Miloshev, Daniela-Cristina Culita, Marin Alexandrov, Luminita Patron. Radostina Alexandrova

11.00 – 11.20 Coffee Break 11.20 – 11.35

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AO4. MACROSCOPIC EVALUATION OF THE PROTECTIVE EFFECT OF ARONIA MELANOCARPA FRUIT JUICE IN A MODEL OF TRINITROBENZENESULFONIC ACID-INDUCED COLITIS IN RATS

S. Valcheva-Kuzmanova1, M. Zhelyazkova1, M. Eftimov1, V. Marinov1, M. Tzaneva2

1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria

11.35 – 12.05 AO5. BIOCHEMICAL EVALUATION OF THE EFFECT OF ARONIA MELANOCARPA FRUIT JUICE IN A MODEL OF TRINITROBENZENESULFONIC ACID-INDUCED COLITIS IN RATS

A. Kuzmanov1, V. Kuzmanova1, S. Valcheva-Kuzmanova2

1Student, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 2Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria

12.05-12.20 AO6. STUDY ON THE EFFECTS OF ALKALINE EARTH METALS ON THE ACTIVITY OF AMINOPEPTIDASE A IN NORMAL AND TUMOR HUMMAN MAMMARY GLAND-DERIVED CELLS

V. Petrova1, V. Pavlova1, I. Iliev1, V. Lozanov2, I. Ivanov2, M. Dimitrova1

1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, , Bulgaria 2Department of Chemistry and Biochemistry, Faculty of Medicine, Medical University –Sofia, Bulgaria

12.20 – 12.35 Discussion

12.35-12.50 Lunch time

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Session B.

Chairpersons: Prof. Ivo Grabchev, MSc, PhD, DSc Faculty of Medicine, Sofia University “St. Kliment Ohridski”

Assoc. Prof. Radostina Alexandrova, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

Secretary: Lora Dyakova, MSc Institute of Neurobiology, Bulgarian Academy of Sciences

13.45 – 14.00 BO1. MACROSCOPIC EVALUATION OF THE EFFECT OF ANETHOLE IN A MODEL OF TRINITROBENZENESULFONIC ACID- INDUCED COLITIS IN RATS

S. Valcheva-Kuzmanova1, M. Zhelyazkova1, M. Eftimov1, V. Marinov1, M. Tzaneva2

1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria

14.00 – 14.30 BO2. S. Valcheva-Kuzmanova

1Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, Varna, Bulgaria 2Department of Preclinical and Clinical Sciences, Medical University Prof. Dr. Paraskev Stoyanov, 9002 Varna, 55 M. Drinov Str., Bulgaria

14.30-15.00 BO3. BIOACTIVE COMPOUNDS ISOLATED FROM GARDEN SNAILS

Pavlina Dolashka1, Aleksander Dolashki1, Lyudmila Velkova1, Stefan Stevanovic2, Laura Molin3, Pietro Traldi3 Radostina Velikova1 and Wolfgang Voelter4 1 Institute of Organic Chemistry; 2 Institute for Cell Biology, Department of Immunology, University of Tübingen, ; 3 R-ISTM, Padova, Italy; 4 Interfacultary Institute of Biochemistry, University of Tϋbingen, Germany

15.00-15.15

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BO4. N- LINKED CARBOHYDRATE STRUCTURES OF MOLLUSCAN HEMOCYANINS FROM SNAILS Lyudmila Velkova1, Aleksandar Dolashki1, Pavlina Dolashka1

1Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

15.15 – 15.35 Coffee Break

15.35-16.05 B05. MICROBIOLOGICAL ACTIVITY OF Cu(II) AND Zn(II) COMPLEXES OF A NEW BENZANTHRONE TRIPOD

D. Staneva1, S. Grabchev2, E. Nikolova2, E. Vasileva-Tonkova3, P. Bosch4, I. Grabchev5

1University of Chemical Technology and Metallurgy, Sofia, Bulgaria 2Sofia University “St. Kliment Ohridski”, Faculty of Chemistry and Pharmacy, Sofia, Bulgaria 3Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria 4Institute of Science and Technology of Polymers, CSIC, Madrid, Spain 5Sofia University “St. Kliment Ohridski”, Faculty of Medicine, Sofia, Bulgaria

16.05 – 16.20 BO6. ACTIVITY OF WATER EXTRACT FROM NEPETA NUDA L. AGAINST ACV-RESISTANT HUMAN HERPES VIRUS TYPE 2 Petia Angelova1, Anton Hinkov1, Venelin Tsvetkov1 , Kalina Shishkova1 ,Daniela Dragolova2, Veneta Kapchina-Toteva2, Stoyan Shishkov1 1 - Laboratory of Virology, Faculty of Biology, University of Sofia ‘‘St. Kl. Ohridski’’, Sofia, Bulgaria 2 - Department of Plant physiology, Faculty of Biology, University of Sofia “St. Kl. Ohridski”, Sofia, Bulgaria

16.20 – 16.35 Discussion

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Wednesday, 15 December 2016

Session C. Chairpersons:

Assoc. Prof. Julia Radenkova-Saeva, MD, PhD Clinic of Toxicology, Department for Adult, Emergency University Hospital “N.I.Pirogov” Assoc. Prof. Radostina Alexandrova, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences Secretary: Boyka Andonova-Lilova, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

9.00-9.30 CO1. TRACKING RESISTANCE OF COMBINATIONS OF PROBIOTIC BACTERIA IN MODEL CONDITIONS OF DIGESTION INCLUDED IN GEL OF CHITOSAN Iliana Nacheva, Aleksandar Valchkov, Kamelia Loginovska, Daniela Mitеva Institute of Cryobiology and Food Technologies, Sofiaq Bulgaria

9.30-10.00 CO2. USAGE EVALUATION OF ZINC INORGANIC COMPOUNDS AND ZINC ORGANIC COMPLEXES (CHELATES) IN REGARD TO THEIR FAVOURABLE PROSPECTS, INVOLVING OVERDOSE BIOASSAYS ON CHICKENS

Sofiya Ivanova1, Katerina Todorova2, Margarita Marinova1, Petar Stamberov3, Georgi Kalistratov1, Russy Russev2

1 National Diagnostic and Research Veterinary Medical Institute, Sofia, Bulgaria 2Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria 3 University of Forestry, Sofia, Bulgaria

10.00 – 10.30

CO3. LYOPHILISED MEAT FOODS DEVELOPMENT FOR SPECIALIZED NUTRITION HAVING RADIOPROTECTIVE EFFECT Daniela Miteva1, Plamen Petrunov2, Iliana Nacheva1, K. Dimov1, A. Valchkov1 Institute of Cryobiology and Food Technologies1, Sofia Military Medical Academy2, Sofia, Bulgaria

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10.30 – 11.00 CO4. "SACRED PLANTS" WITH PSYCHOACTIVE PROPERTIES Radenkova-Saeva J. Toxicology Clinic, UMHATEM “N.I.Pirogov”, Sofia, Bulgaria

11.00 – 11.20 Coffee Break

11.20 – 11.50 CO5. Pencho Beykov Boykov Faculty of Chemistry and Pharmacy, Sofia University St. “Kl. Ohridski”

11.50 – 12.05 CO6. Консумация на алкохол и окислително увреждане на ДНК. Мария Минчева и Катя Попова

12.05 – 12.30 Discussion

12.30 – 13.45 Lunch time

13.45-14.00 CO7. ZINK IN THE ETIOLOGY OF ACRODERMATITIS ENTEROPATHICA Liliya Lazova, Vasil Boyanov Medical University of Sofia

14.00 – 14.15 CO8. TOPICAL IMMUNOTHERAPTY TREATING ALOPECIA Vasil Boyanov, Liliya Lazova Medical University of Sofia

14.15 – 14.30 CO9. SILYMARIN AND LIVER Liliya Lazova, Vasil Boyanov Medical University of Sofia

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Friday, 16 December 2016

Session D. Chairpersons: Assoc. Prof. Anna Tolekova, MD, PhD Medical Faculty, Trakia University, Stara Zagora, Bulgaria

Assoc. Prof. Radostina Alexandrova, MSc. PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

Secretary: Desislav Dinev, MSc Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

9.00 – 9.30 DO1. Boyka Andonova-Lilova, Radostina Alexandrova Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

9.30 – 10.00 DO2. INFLUENCE OF THE REACTION MEDIUM ON THE CHEMICAL, PHASE AND MORPHOLOGICAL CHARACTERISTICS OF DOUBLE-DOPED AMORPHOUS CALCIUM PHOSPHATES

K. Sezanova, R. Gergulova, D. Rabadjieva, S. Tepavitcharova, R. Ilieva

Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

10.00-10.15 DO3. RAT BLOOD BIOCHEMICAL MARKERS TESTED AFTER CALVARIA IMPLANTATION WITH ION-MODIFIED CALCIUM PHOSPHATE BIOMATERIALS

Kostadinka Sazanova2, Marin Alexandrov1, Veselin Nanev1, Neli Tsocheva-Gaytandzhieva1, Ivelin Vladov1, Petar Dimitrov1, Margarita Gabrashanska1

1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

2Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

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10.15 – 10.30 DO4. SYNTESIS AND CHARACTERIZATION OF NEW DOUBLE QUATERNARY POLYMERS AND THEIR HYDROGELS AS BIOMATERIALS WITH POTENTIAL ANTIMICROBIAL APPLICATIONS Denitsa Nikolova1, Konstans Ruseva1, Stephan Metsov2, Elena Vassileva1 1Laboratory on Structure and Properties of Polymers; 2Department of Pharmaceutical and Applied Organic Chemistry, Faculty of Chemistry and Pharmacy, Sofia University “St. Kl. Ohridski, Sofia Bulgaria

10.30 – 11.00 DO5. Ability of polyether ionophore Monensin to bind La(III) metal ions Veneta Ivanova1, Ahmed Nedzhib2, Ivayla Pantcheva1

1Laboratory of Biocoordination and Bioanalytical Chemistry, Faculty of Chemistry and Pharmacy, "St. Kl. Ohridski" University of Sofia, Bulgaria 2Research Laboratory of Military Toxicology, Department of Disaster Medicine and Toxicology, Military Medical Academy, Sofia, Bulgaria

11.00 – 11.20 Coffee Break

11.20 – 11.50 DO6. PCR DETECTION OF SIX TRICHINELLA SPECIES V. Dilcheva, I. Vladov, S.Petkova Institute of experimental morphology, pathology and anthropology with museum (IEMPAM), Bulgarian Academy of Sciences, Sofia, Bulgaria

11.50 -12.05 DO7. ANALYSIS OF SOME LIVER BIOCHEMICAL INDICES AND PARAMETERS OF THE STATE OF HEALTH IN ASCARIDIA GALLI INFECTED AND BASIC ZINC-COPPER SALT TREATED CHICKS

Veselin Nanev, Ivelin Vladov, Margarita Gabrashanska, Neli Tsocheva-Gaytandzhieva

Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

12.05 – 12.20 DO8. КРАТЪК ПРЕГЛЕД НА ОПИТА В ПРОТИВОПАРАЗИТНОТО ТРЕТИРАНЕ НА ДИВИ ПРАСЕТА Василена Дакова, Мариана Панайотова-Пенчева, Делка Салкова Институт по експериментална морфология, патология и антропология с музей, Българска Академия на Науките, София, България

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12.20 – 12.35 DO9. ФОЛИЕВА КИСЕЛИНА Надежда Стоянова1, Стефани Димитрова1, Емил Белински 1Медицински университет София, Медицински факултет Клиника по съдова хирургия, Токуда Болница, София

12.35 – 13.45 Lunch time

Session E. Chairpersons: Prof. Anna Tolekova, MD, PhD Medical Faculty, Trakia University, Stara Zagora, Bulgaria Assoc. Prof. Radostina Alexandrova, MSc, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

Secretary: Abedulkadir Abudalleh, MSc, PhD Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

13.45 – 14.00

EO1. BEIGE CELLS AND DO THEY HAVE A POSSIBLE ROLE IN THE TREATMENT OF METABOLIC SYNDROME Angel Todev, Alexander Brunkov, Viktoriya Trendafilova

14.00-14.15 EO2. ENDOTELIAL RECEPTORS ANTAGONISTS IN PULMONARY HYPERTENSION Yuksel Mekov, Georgi Madjarov

14.15 – 14.30

EO3. EXPERIMENTAL MODEL FOR DIET- INDUCED DIABETES TYPE 2 Petya Hristova, Vencislava Dimitrova, Daniel Addai, Jacqueline Zarkos

14.30 – 15.00 EO4. PODOPLANINS AS MARKERS FOR ANGIOSARCOMA Georgi Madjarov, Yuksel Mekov

15.00 – 15.20 Coffee Break 9

15.20-15.50 EO5. COMPLECATED FACE OF MULTIPLE SCLEROSIS Sonya Ivanova*, Vera Kolyovska**

*University Hospital for Active Treatment in Neurology and Psychiatry; “St. Naum”, Medical University of Sofia, Bulgaria ** Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

15.50 -16.20 EO6. One in six people is at risk for stroke. It could be prevented. Act now.

Vera Kolyovska*, Desislava Drenska**, Dimitar Maslarov**

* Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Sofia, Bulgaria, ** Neurology Clinic, First MHAT-Sofia

16.20-16.35 Discussion 16.35-16.50 Closing Remarks

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