1 Supplementary information 2 3 4 Site description of deep-sea seafloor samples 5 6 All sediment cores used in this study were retrieved from bathyal or abyssal depths. The two Pacific 7 cores are fully oxic, whereas dissolved oxygen was not detectable in the middle part of NP_U1383E 8 and the basal part of GS14-GC08 (Fig. S1). All except one (GC08-250 cm) of the metagenome 9 sequencing datasets were generated from oxic sediment where nitrate was also detected in the porewater 10 (Fig. 1b). 11 12 Amplicon sequencing and analysis 13 14 16S rRNA gene amplicons of the Atlantic sediments were prepared using primers Uni519f/806r and 15 sequenced using an Ion Torrent Personal Genome Machine described previously [1]. The amplicons of 16 the Pacific samples were prepared using a universal primer set of U530F and U907R and sequenced 17 using Illumina MiSeq platform, following the procedure described in [2, 3]. To study the overall 18 community structure of Thaumarchaeota, the sequencing data were processed as described elsewhere 19 [1]. Briefly, the reads were quality-controlled and OTUs (97% nucleotide similarity threshold) were 20 clustered using USEARCH and classified using CREST. For individual cores, OTUs classified as 21 Nitrosopumilales were extracted from the OTU tables, and their clade affiliations were assigned based 22 on their placement in the Nitrosopumilales 16S rRNA gene phylogenetic tree presented in [4]. 23 24 High similarity between genomes from the Pacific and Atlantic sediments 25 26 Although the NP-iota MAGs (NPMR_S100_NP_iota_1 and YK1309_1N_S300_NP_iota) were 27 assembled from metagenomic datasets of marine sediments in the Pacific and Atlantic oceans 28 respectively, these MAGs showed 99 % ANI (Fig. S1), suggesting that these bins might represent 29 different strains of the same species (prokaryotic species usually show > 95 % ANI among themselves 30 [5, 6])⁠. A similar pattern was observed between the Pacific bin YK1312_12N_S200_NP_theta and the 31 Atlantic bin NPMR_S100_NP_theta_3, exhibiting > 97 % ANI. It has been shown that prokaryotes 32 with close phylogenetic affiliation inhabiting deep marine sediments and subsurface oceanic crust are 33 commonly retrieved in distant geographic locations [7, 8]⁠, possibly due to the circulating seawater that 34 allows the dispersion of subsurface and benthic microbial phyla [9]⁠. 35 36

1 37 Taxonomic placement of NPMR_NP_delta_1 38 39 Based on the amoA tree MAG NPMR_NP_delta_1 clustered within the NP-theta clade (Fig. 2b) but 40 the more robust phylogenomic analysis strongly suggests that it belongs to the NP-delta subclade (Fig 41 2a). We argue that the amoA gene in this MAG (in which amoAXC are the sole genes of a small contig) 42 might represent a contamination considering that NP-delta and NP-theta have similar ecological 43 distribution [4];⁠ this study) and the phylogenomic tree reconstruction with 79 single-copy gene markers 44 shows clearly that this MAG is placed within the NP-delta lineage. 45 46 Notes on the evolution of AOA lineages from comparative genomics 47 48 Interestingly, our estimation of 269 AOA-specific core families is close to the estimation of 289 protein 49 families inferred to have been gained by the last common ancestor of AOA (Abby et al., 2020, 50 submitted). We observed that extensive differential gene loss (and possibly gene acquisitions) have 51 occurred at the origin of major AOA lineages as is attested by the great number of families shared 52 between different combinations of protein families present in 2, 3 or 4 lineages only (Fig. 3, S2). 53 Similarly, we found that each AOA lineage harbors between 500 to more than 3000 lineage-specific 54 families suggesting a complex genomic evolution and a considerable number of gene acquisitions at 55 the origin and during the diversification of AOA lineages, possibly associated to habitat adaptations 56 [10–12] (Abby et al., 2020)⁠. 57 58 Based on genomic context analyses and considering the phylogenetic position of the NP-iota clade in 59 the context of the scenario proposed by [13], it is plausible that the V-type ATPase was acquired by the 60 common ancestor of NT/NP clades, followed by selective losses of one or the other in the resulting 61 clades according to their environmental radiation. Genomic context analysis reveals that in NP-iota 62 MAGs, the two operons are encoded next to each other, and flanked by the pyrI, pyrB and sulfT genes 63 which are also the flanking genes of the V-type ATPase operon in NT and NP-alpha genomes/MAGs, 64 as well as the A-type ATPase operon in all other NP clades [13]. In abysso/hadopelagic NP-gamma 65 AOA, the V-type ATPase operon is located elsewhere in the genome (Table S3), implying an 66 independent acquisition [13]. In any case, this distribution suggests that the acquisition of the proton- 67 pumping ATPase variant was crucial for successful radiation into hadal high-pressure environments 68 and raises intriguing possibilities about the ecophysiological potential of the ancestor of 69 Nitrosopumilales (see evolution scenario above). 70 71 72

2 73 Usage of exogenous organic compounds and high pressure adaptations 74 75 The thaumarchaeal putative lactate racemase family enzyme has a 32% amino acid identity (1e-59) to 76 the characterized LarA from Lactobacillus plantarum, and is a nickel-dependent enzyme activated by 77 a maturation system [14] also found in the sediment AOA bins (Table S3). In lactobacilli, D-lactate is 78 an important cell wall component conferring resistance to vancomycin [15], a glycopeptide antibiotic 79 which inhibits cross-linking of N-acetylmuramic acid (NAM)/ N-acetylglucosamine (NAG) polymers. 80 NAG/NAM is also a component of the thaumarchaeal cell surface, given the presence of NAG-utilizing 81 enzymes in AOA (Table S3, [16]). The presence of Lar would enable the utilization of both lactate 82 stereoisomers produced by the sediment fermentative community. The transport of lactate could be 83 mediated by MIP family transporters (aquaporins) [17] common in AOA, as in lactobacilli. It has to be 84 noted though that this enzyme belongs to a large superfamily of proteins with broad distribution in non- 85 lactate utilizing organisms, probably catalyzing other racemization reactions [15, 18]. Phylogenetic 86 analysis of the superfamily PF09861 of which LarA is a member reveals that the AOA homologs belong 87 to a separate, but neighboring, cluster from the characterized LarA homologs from lactobacilli, leaving 88 the question of the putative substrate open (Fig. S6) 89 90 The malate dehydrogenase (MDH) homologs encountered in AOA belong to the LDH-like MDH 91 subgroup within the LDH/MDH superfamily of 2-ketoacid:NAD(P)-dependent dehydrogenases, as 92 other archaeal MDHs [19]. In terms of primary sequence, quaternary structure and enzymatic 93 properties, characterized archaeal homologs are between canonical MDHs and LDHs, possessing clear 94 activity with oxaloacetate (as the former) but also able to utilize pyruvate (as the latter), while also 95 exhibiting relaxed cofactor specificity (NADH or NADPH) [19, 20]. The active site architecture 96 surrounding the universally conserved substrate binding residue (Arg171) resembles the environment 97 found in canonical LDHs in AOA homologs, as in the characterized LDH-like MDH from Ignicoccus 98 islandicus (Fig S5) [19]. In particular, while position 102 is occupied by an arginine and a neutral 99 residue (methionine) is found in position 199, as in canonical MDHs, a threonine at position 246 and a 100 histidine at position 68, typical LDH residues, may influence substrate selection and charge balance 101 respectively (Fig. S5, residues highlighted in orange) [19, 20]. We therefore hypothesize that AOA 102 homologs exhibit a broad substrate specificity and are in principle able to convert lactate to pyruvate, 103 with the concomitant formation of NADH (cofactor preference for NADH is inferred by the presence 104 of Asp54, highlighted in green in Fig. S4). However, whether this actually takes place in vivo 105 necessitates enzymatic characterization. 106 107 No genes associated with the glycine cleavage system or choline/betaine degradation present in certain 108 hadopelagic NP-gamma and NP-alpha lineages [21, 22] were identified in any of the sediment bins 109 (Fig. S4).

3 110 Interestingly, a part of the NADH dehydrogenase (complex I) operon is duplicated in two out of three 111 NP-delta MAGs (Fig. 5, Table S3) specifically genes nuoIJKML in NPMR_NP_delta_1 and 112 nuoHIJKM in NPMR_NP_delta_3, bearing 85-95% amino acid identity. Unfortunately, these 113 duplicated regions are in single contigs and therefore it is unclear whether the whole operon is 114 duplicated. It is intriguing, however, that these regions contain the proton pumping subunits of complex 115 I, raising the possibility that this could either be a mechanism to alleviate cytoplasm acidification under 116 high pressure if the complex is running in the forward direction and pumping protons out, similar to the 117 V-type ATPase. It should be noted here that Complex I is postulated to run in reverse in nitrifiers [23, 118 24]. Duplicated subunits or multiple copies of complex I are observed in various microorganisms 119 including members of AOB and NOB, and are associated with increasing proton-pumping capacity or 120 providing different electron flow options by operating in different directions, respectively [25–27]. 121 Facultative piezophiles such as Shewanella violacea has been shown to encode distinct complexes of 122 the respiratory chain (such as different versions of terminal oxidases) as an adaptation to growth at 123 different pressure conditions [28]. 124 125 Usage of amino acids (AA) 126 127 Enzymes participating in canonical amino acid biosynthesis pathways and present in almost all AOA 128 (e.g. aspA, ilvA, ilvE, aspC glyA, GDH) could enable the utilization of imported amino acids such as 129 Asp, Gly, Ser, Thr, Ile, Val, Leu, Phe, Tyr into their corresponding α-ketoacids or dicarboxylic acids 130 by releasing a molecule of ammonia (Fig. 5, S4, Table S3). Only the catabolism of proline to glutamate 131 by proline dehydrogenase (ProDH) and 1-pyrroline-5-carboxylate dehydrogenase (RocA), two 132 enzymes with conserved gene synteny, is not widespread in AOA but present only in certain clades 133 (Fig. 5, S4). Proline catabolism would generate reducing equivalents (Fig. 5) and result in the 134 production of glutamate, which can be used to regulate the ammonia pool via the action of glutamate 135 dehydrogenase (GDH) or would have a possible role in osmoregulation [29]. A type-III 136 aminotransferase (Oat, CLUSTER_3296) encoded by the NP-theta, NP-iota MAGs could also 137 participate in replenishing the intracellular ammonia stock by catalyzing the transamination between a 138 variety of amino acids, mono- and diamines and α-ketoacids (Fig. 4, 5). 139 140 In obligate piezophiles such as Thermococcus barophilus, a drastic increase in AA requirements during 141 HHP growth, even for those where biosynthesis pathways are present, was interpreted as a switch from 142 energy-intensive AA biosynthesis towards recycling, in the context of the general metabolic response 143 towards more efficient energy utilization under HHP [30–33]. A downregulation of AA biosynthesis 144 pathways (especially glutamine, glutamate and costly aromatic AA), together with an upregulation of 145 AA transport systems is observed during HHP growth in transcriptomic studies of facultative 146 piezophiles Desulfovibrio hydrothermalis and Desulfovibrio piezophilus, While this was interpreted as

4 147 solely resulting in glutamate accumulation in the cells (acting as a piezolyte), the accompanying shift 148 in the energy metabolism of these organisms towards increased energy efficiency could also be taken 149 as evidence of AA recycling. Moreover, in obligate piezophiles such as Pyrococcus yayanosii, certain 150 AA biosynthesis pathways have been altogether lost [34], while P. abyssi also requires 9 amino acids 151 for growth despite possessing biosynthesis pathways [35]. 152 153 Transporter complement of sediment clades 154 155 All deep sediment clades encode the ion transporter repertoire typical for marine microorganisms (Table 156 S3, Fig S4)([21–23, 36–39]: aquaporins (MIP family), small conductance mechanosensitive channels 157 (MscS, accompanied by an absence of the large conductance MscL), NhaP-type K+(Na+)/H+ antiporters 158 (CPA1 family), while the low affinity but rapid uptake Trk family transporter is only encoded by the 159 NP-theta and NP-gamma clades. Additionally, NP-theta, NP-iota, hadopelagic NP-gamma and deep 160 marine NP-alpha lineages encode ArsB family Na+/H+ antiporters. 161 162 Motility and attachment 163 164 Only the NP-delta bins encode a complete repertoire for archaellum assembly and chemotaxis, while 165 both NP-delta and NP-theta clades encode putative Type IV pili assembly clusters (Fig 4, 5, S4, Table 166 S3). The absence of an archaellum in the clades most adapted to this habitat is not surprising, as this is 167 one of the most sensitive apparatuses and processes to high hydrostatic pressure, while also extremely 168 energy demanding and therefore rarely occurring in sediment lineages [31, 40, 41]. Conversely, the 169 capacity for attachment indicated by the Type IV pili could provide the possibility to adhere to energy- 170 rich particles, and has been implicated in starvation survival strategies [31]. It would appear therefore 171 that active migration (at a huge energy cost) in the sediment column would be an option only for NP- 172 delta, while NP-theta representatives are well adapted to a sedentary lifestyle. 173 174 Information processing systems, DNA and protein repair 175 176 DNA depurination is the most common source of age-induced DNA damage in marine sediments [42, 177 43]. The main DNA repair systems in the three sediment lineages seem to be double strand break repair 178 (DBSB) via homologous recombination (HR), and base excision repair (BER), while key NER enzymes 179 such as XPD and XPB/Bax1 are missing, as in most Ca. Nitrosopumilales & Ca. Nitrosotaleales (Table 180 S3, Fig 4, 5 & S4). While all essential proteins for HR are present in NP-theta and ΝP-iota, NP-delta 181 bins lack a homolog of the Hef helicase domain protein involved in repair of stalled replication forks 182 [44]. However, functional redundancy between Hef and Hjc (Holliday junction resolvase), present in

5 183 all AOA, has been observed in H. volcanii, ensuring that all sediment bins are able to process Holliday 184 junctions and restart collapsed replication forks [45]. 185 186 The arsenal of monofunctional and bifunctional DNA glycosylases and endonucleases involved in base 187 excision repair (BER) [46], the pathway responsible for the repair of modified (oxidized, alkylated or 188 deaminated) or mismatched bases is present, with some differences, in all sediment clades (Fig. 4, 5, 189 S4). For example, while NP-theta bins encode uracil DNA glycosylases of families 4&5 (Udg), a 190 methylpurine/alkyladenine-DNA glycosylase (Mpg), a 3-methyladenine DNA glycosylase (AlkA) and 191 an 8-oxoguanine (8-oxoG) DNA glycosylase (Ogg1), NP-delta bins encode only family 5 Udg and 192 AlkA glycosylases, while NP-iota bins encode family 4 Udg, Mpg and Ogg1 glycosylases as in hadal 193 NP-α lineages [22]. Additionally, they all encode, as all AOA, an EndoIII/Nth homolog, which has both 194 8-oxoG DNA glycosylase/AP (apurinic or apyrimidinic site) lyase activities. It is plausible that NP- 195 theta bins encoding four different DNA glycosylases are better equipped at recognizing various types 196 of DNA damage than other NP clades. However, it should be noted that while all superfamilies of 197 glycosylases exhibit substrate specificity, e.g. Udg for uracil pairs [47], Ogg1 for 8-oxoG, AlkA and 198 Mpg for methylated and alkylated bases [48], there is a substrate overlap among superfamily members 199 (e.g. among AlkA and Mpg), so in principle all clades have the capability to recognize the basic types 200 of damaged bases. 201 202 The UvrABC system of NER [49, 50], present in AOA, is present only in NP-delta and one NP-theta 203 bin and is also absent from the hadalopelagic and deep marine NP representatives (Fig. 4, 5, Table S3). 204 Interestingly, the Uvr system has been implicated in transcription-coupled repair in halophilic archaea 205 [51]. 206 207 While all clades encode the single subunit family B polymerase PolB1, no family D polymerase 208 subunits (DP1, DP2) were detected in NP-iota (Fig. 5, S4). The absence of PolD is also observed in 209 hadal lineages belonging to the NP-alpha clade (erroneously referred to as PolB by [22]) as well as Ca. 210 Nitrosocaldales [10, 52]. This provides even stronger support to the hypothesis that PolB1 is the 211 replicative polymerase in Thaumarchaea, performing both leading and lagging strand synthesis as in S. 212 solfataricus [53]. This would indicate that PolD in those Thaumarchaea where present has a secondary 213 role in repair, in reversal to the situation observed in Euryarchaeota where PolD is the replicative 214 polymerase while the recognition and complete inhibition by deaminated bases of PolB (PolB3 group) 215 implicated it in repair pathways [54–56]. In the absence of any functional data for the thaumarchaeal 216 polymerases, it is unclear what role PolD plays in repair and what kind of impediment is caused by its 217 absence. Data from euryarchaeal homologs however indicate that this family also stalls upon 218 encountering deaminated bases and can inhibit BER, and could therefore participate in replication- 219 associated repair [54].

6 220 221 NP-theta and NP-iota bins encode a protein-L-isoaspartate carboxylmethyltransferase homolog (pcm), 222 responsible for the repair of D-aspartyl residues in proteins, also found in NP-gamma and NP-eta clades 223 (Fig. 4, 5)[36]. Spontaneous aminoacid racemization is one the most important causes of protein 224 damage in the subsurface marine environments due to the low turnover rates [57], indicating an energy 225 investment towards cell maintenance. 226 227 Adaptation to the low temperatures in the deep sediments is assisted by homologs of the cold-shock 228 protein CspC [58], present in the NP-theta and NP-gamma clades, and the cold-shock DEAD-box 229 protein A (CshA), present in all NP (Fig. 4, 5) [59]. 230 231 232 Supplementary Methods Information 233 234 Porewater geochemistry of Pacific sediment samples 235 236 Sample processing of Pacific sediment cores: Upon recovery on board, sediment cores were kept in a 237 cold room (4ºC) prior to sample processing. Overlying water was gently sampled and filtrated for 238 geochemical analyses, and then sediment cores were sliced horizontally into 1 to 5cm thickness of 239 sediments. For porewater extraction, sediment samples were immediately centrifuged at 2600 g for 5 240 min. Extracted porewater were filtered with a 0.45-µm membrane filter and stored at -20° C. Samples 241 for molecular analyses were stored at -80ºC. Porewater geochemistry of the Pacific sediment samples 242 is described in Supplementary Information. 243 244 Dissolved oxygen (DO) concentrations in the sediment cores were measured onboard immediately after 245 core recovery using a planar optode oxygen sensor Fibox 3 (PreSens, Regensburg, Germany). The 246 sensor spots were attached to the inside of the transparent polycarbonate core liner tube and oxygen 247 concentrations were measured from the outside [60]. The sensors were calibrated with air-saturated and 248 oxygen-free seawater before measurements. 249 250 Nutrient concentrations were measured with a continuous-flow analyser (BL-Tech QUAATRO 2-HR 251 system) [61] onboard. The precision of the phosphate, nitrate, nitrite, and ammonium measurements, 252 based on duplicate measurements, was ± 0.17%, ± 0.17%, ± 0.16%, and ± 0.38%, respectively. When 253 a nutrient concentration exceeded the calibration range, the filtrated porewater was diluted with 254 nutrient-free seawater and were measured again to reduce the concentration to within the calibration 255 range. 256

7 257 DNA extraction, library construction and sequencing 258 259 DNA for metagenomic sequencing from the Atlantic sediment samples was extracted from ~7 g 260 sediment (~0.7 g sediment in 10 individual lysis tubes) using PowerLyze Soil DNA Isolation Kit 261 (MoBio Laboratories) following the manufacturer’s instructions, except for the following minor 262 modification: the lysing tubes were incubated in water bath of 60oC for 15 min prior to beading beating 263 at the highest speed (grade of 6) for 45 seconds on the MP machine. The DNA extracts were iteratively

264 eluted from the 10 spin columns into 100 µL of ddH2O for further analysis. 265 266 DNA was sheared into 400 bp fragments using Covaris, and libraries were constructed using a Nextera 267 DNA Flex Library Prep kit (Illumina). Metagenomic libraries were sequenced (2×150 bp paired-end) 268 by an Illumina Hiseq 2500 sequencer at the Vienna Biocenter Core Facilities GmbH (Vienna, Austria). 269 270 DNA extraction, purification and shotgun metagenomic library construction from the Pacific sediment 271 samples were conducted as described previously [3]. Briefly, from approximately 5 g of the frozen 272 sediment DNA was extracted using DNeasy PowerMax Soil Kit (QIAGEN) and further purified with 273 DNA Clean up MagExtractorTM –PCR & Gel Clean up- (TOYOBO). Then, shotgun metagenomic 274 libraries were constructed using KAPA Hyper Prep Kit from 1 ng DNA or less. The metagenomic 275 sequence libraries were analyzed using Illumina HiSeq2500 with rapid mode (250 bp paired-end). 276 277 Assembly and genome binning of Atlantic sediments 278 279 The sequencing data were processed with Trimmomatic v.0.36 [62] to remove illumina adapters and 280 low quality reads (“SLIDINGWINDOW:10:25”). The quality-controlled reads from the eight samples 281 were de novo co-assembled into contigs using Megahit v.1.1.2 [63] with the k-mer length varying from 282 27 to 117. Contigs larger than 1000 bp were into automatically binned with MaxBin2 v2.2.5 [64] using 283 the default parameters. The quality of the obtained genome bins was assessed using CheckM v.1.0.7 284 [65] with the option “lineage_wf”, which uses lineage-specific sets of single-copy genes to estimate 285 completeness and contamination and assigns contamination to strain heterogeneity if amino acid 286 identity is >90%. Genome bins of >50% completeness were manually refined using the gbtools [66] 287 based on the GC content, taxonomic assignments, and differential coverages in different samples. 288 Coverages of contigs in each sample were determined by mapping trimmed reads onto the contigs using 289 BBMap v.37.61 [67]. Taxonomy of contigs were assigned according to the taxonomy of the single- 290 copy marker genes in contigs identified using a script modified from blobology [68] and classified by 291 BLASTn. SSU rRNA sequences in contigs were identified using Barrnap (Seeman 2015, Github), and 292 classified using VSEARCH with the SILVA 132 release [69] as the reference.

8 293 To improve the quality of the Thaumarchaeota genomes, we recruited reads from highest-abundance- 294 sample (i.e. highest genome coverage) using BBMap as described above, and the recruited reads were 295 re-assembled using SPAdes v.3.12.0 [70]. After removal of contigs shorter than 1 kb, the resulting 296 scaffolds were visualized and re-binned muanlly using gbtools [66] as described above. The quality of 297 the resulting Thaumarchaeota genomes were checked using the CheckM v.1.0.7 “lineage_wf” 298 command again, based on the Thaumarchaoeta marker gene set (automatically selected by CheckM). 299 300 Metagenomic assembly and binning of Pacific samples 301 302 The reads of the 6 metagenomic samples from deep marine sediments of the Pacific Ocean were quality 303 trimmed and illumina adapters were removed using Trimmomatic [62]⁠. Low-complexity 304 homopolymeric reads (sequences with more than 80% of a single nucleotide) were removed with 305 PRINSEQ [71]⁠. The quality trimmed reads of each metagenomic sample were assembled independently 306 using MEGAHIT [63]⁠. The trimmed reads of all Pacific metagenomes were then mapped back onto the 307 6 different assemblies using the bowtie2 tool [72]⁠. 308 309 The contigs of the six metagenomes were binned with CONCOCT [73]⁠, MetaBAT [74]⁠ and MaxBin 2 310 [64]⁠ followed by contig dereplication and binning optimization using the DAS tool [75]⁠. Completeness 311 and contamination of bins were evaluated through single copy-marker gene comparison with CheckM 312 (same parameters as above) [65]. Prodigal [76]⁠ was employed with default parameters to predict 313 proteins of optimized bins. 314 315 Phylogeny of amoA sequences 316 317 The nucleotide amoA sequences of the MAGs reported in this study were retrieved via BLASTN 318 searches (E-value 10-10) using the amoA sequence of Nitrosopumilus ureiphilus (KX950756.1). The 319 amoA sequences were incorporated into the curated alignment of amoA genes reported by [77],⁠ using 320 MAFFT v7 (“--add” parameter) [78]⁠ followed by the manual inspection of the alignment. 321 322 The maximum likelihood phylogenetic tree of amoA sequences was reconstructed using IQTREE (v2.0- 323 rc1) [79]⁠ with a GTR+F+I+G model of sequence evolution using a constrained tree search (“-g” 324 parameter) based on the phylogenetic tree reported in [77], and 1,000 ultrafast bootstrap replicates⁠. 325 326 327

9 328 Annotation and comparative genomics analysis 329 330 In addition to the 11 AOA MAGs reported in this work (Table 1), we downloaded 18 completely 331 sequenced AOA genomes, 13 nearly complete genomes and 43 metagenome-assembled or single- 332 amplified genomes from NCBI or IMG database (date: December 2019). In total, our genome collection 333 was composed of 85 genomes (77 AOA plus 8 non-AOA Thaumarchaeota). The complete list of 334 genomes is provided in Table S1. All MAGs and SAGs collected from public databases are more than 335 70 % complete and have less than 5% contamination, except for Marine Group I thaumarchaeote SCGC 336 RSA3 and Marine Group I thaumarchaeote SCGC AB-629-I23 which are more than 90 % complete 337 and have less than 10 % contamination. Prodigal [76]⁠ was used with default parameters to predict 338 protein sequences when this information was not provided. Annotation of the MAGs assembled in this 339 study was performed automatically using the Microscope annotation platform from Genoscope [80], 340 followed by extensive manual curation. 341 342 ANI comparisons 343 344 Pairwise average nucleotide identity comparisons between MAGs were performed using the ANI script 345 from the enveomics collection [81]. 346 347 Sequence alignment 348 349 Primary sequences were aligned with Mafft [82] and visualized with BOXSHADE (ExPASy). 350 351 Data availability 352 353 Raw reads from metagenomic sequencing as well as 16S and amoA amplicons have been submitted to 354 NCBI under project accession numbers PRJNA489438, PRJNA529480 (Atlantic samples) and 355 PRJDB9793 (Pacific samples). Assemblies of MAGs reported in this study are available at NCBI under 356 accession numbers (pending) and available in the Microbial Genome Annotation & Analysis Platform 357 Microscope (https://mage.genoscope.cns.fr/microscope/home/index.php) [80]. 358 359 360 361 362 363 364 365

10 366 Supplementary Figures 367 368 369 Supplementary figure 1 (S1). Porewater profiles of oxygen and nitrate in the sediment cores used in 370 this study. In the two Pacific cores (YK1309-1N and YK1312-12N), the dashed lines denote the 371 sediment-water interface. Note in the two Atlantic cores the sediment-water interfaces were not 372 properly recovered by the piston/gravity coring. Different axis scales were used for different cores. Data 373 of NP-U1383E were from [1], and GS14-GC08 from [83]. 374 375 Supplementary figure 2 (S2). Pairwise average nucleotide identity calculations among the the deep 376 marine sediments-derived MAGs. The archaeon CSP1 MAG was included in the analyses to have all 377 the representatives of the NP-delta clade. 378 379 Supplementary figure 3 (S3). ML Phylogenetic tree of 2HADH sequences. 380 A dehydrogenase protein cluster comprising 14 sequences (colored in blue in the phylogenetic tree) 381 was added using MAFFT v7 [82]⁠ (“mafft-linsi –add”) to the structure-based reference alignment of 382 2HADH utilized by [84].⁠ The alignment was trimmed in trimmAl⁠ (“trimal -gt 0.2”) and a ML 383 phylogenetic tree was calculated using IQTREE (v2.0-rc1) [79] with a GTR+F+I+G model and 1,000 384 ultrafast bootstrap replicates⁠. Yellow circles represent nodes with 100 % bootstrap support. The scale 385 bar indicates the number of amino acid substitutions per site. 386 387 Supplementary figure 4 (S4). Extended heatmap depicting the distribution and abundance of genes 388 involved in the main functional categories discussed in the text. Abbreviations: nit2, nitrilase/omega- 389 amidase; ureA, urease subunit gamma; mco1, multicopper oxidase family 1; fdh, formate 390 dehydrogenase; larA, lactate racemase; pgi, phosphoglucose isomerase; proDH, proline dehydrogenase; 391 rocA, 1-pyrroline-5-carboxylate dehydrogenase; oat, putative ornithine--oxo-glutarate 392 aminotransferase/class III aminotransferase; ggt, g-glutamyl transpeptidase; kal, 3-aminobutyryl-CoA 393 ammonia lyase; kat, putative 3-aminobutyryl-CoA aminotransferase; argD, acetylornithine 394 transaminase; serC, serine-puryvate aminotransferase; ilvA, threonine/serine ammonia-lyase; ilvE, 395 branched-chain-amino-acid transaminase; aspC, aspartate/tyrosine/aromatic aminotransferase; 396 gvtTPH, glycine cleavage system proteins T/P/H; metH, methionine synthase II (cobalamin- 397 independent); metE, methionine synthase I (cobalamin-dependent); tbp, TATA-box binding protein; 398 rpoS54, AAA family ATPase/RNA polymerase sigma factor 54 interaction domain; phr, photolyase; 399 polD2, DNA polymerase D, large subunit DP2; uvrABC, the Uvr excision repair system endonucleases 400 ABC; hef, Hef/FANCM/Mph1-like helicase; udg4/5, Uracil DNA glycosylase family 4/5; mpg, 401 methylpurine/alkyladenine-DNA glycosylase; ogg1, 8-oxoguanine DNA glycosylase; alkA, DNA-3- 402 methyladenine glycosylase; tag, 3-methyladenine DNA glycosylase; endoV, endonuclease V; POP4,

11 403 RNase P/RNase MRP subunit p29, uspA, universal stress protein A; pcm, protein-L-isoaspartate 404 carboxylmethyltransferase; ipct/dipps, bifunctional CTP:inositol-1-phosphate cytidylyltransferase/di- 405 myo-inositol-1,3′-phosphate-1′-phosphate synthase; cspC, cold-shock protein A; cshA, cold-shock 406 DEAD-box protein A; LLM, luciferase-like monooxygenase family protein; nanM, N-acetylneuraminic 407 acid mutarotase; flaK, archaeal preflagellin peptidase FlaK; cheY, chemotaxis response regulator 408 CheY; cheAB, chemotactic sensor histidine kinase cheA & methylesterase cheB; XerD/XerC family 409 integrases; Protease and transporter classes can be found in Table S4. All locus tags and cluster 410 information are in Supplementary tables 3 & 4. 411 412 Supplementary figure 5 (S5). Sequence alignment of lactate dehydrogenase (LDH) and malate 413 dehydrogenase (MDH) homologs, shaded in yellow and green, respectively. Conserved residues are 414 shaded in black and grey. The universally conserved substrate binding Arg171 in the LDH/MDH 415 superfamily is indicated in red. Residues important for substrate discrimination and active site 416 architecture are shaded in orange and discussed in the text. The residue determining the cofactor 417 specificity is shaded in green. Residue numbering refers to the LDH numbering as in [19]. 418 Primary sequences from the following organisms were used to generate the alignment (Uniprot 419 accession numbers in parentheses): Gster, Geobacillus stearothermophilus (P00344); Tth, Thermus 420 thermophilus (Q5SJA1); Blon, Bifidobacterium longum (E8ME30); Ctep, Chlorobaculum tepidum 421 (P80039); Nvie, Nitrososphaera viennensis (A0A060HG74); Nmar, Nitrosopumilus maritimus 422 (A9A450); Nkor, Nitrosarchaeum koreense (F9CUM5); Nbrev, Ca. Nitrosopelagicus brevis 423 (A0A0A7V4F4); Nuzo, Ca. Nitrosotenuis uzonensis (V6AR53); Mjan, Methanocaldococcus 424 jannaschii (Q60176); Iisl, Ignicoccus islandicus (A0A0U3FQH7); Msed, Metallosphaera sedula 425 (A4YDY0). Sequences from the marine sediment AOA MAGs reported in this study are in bold and 426 their locus tags can be found in Table S3. 427 428 Supplementary figure 6 (S6). Phylogenetic tree of lactate racemase sequences. A total of 1813 proteins 429 of the PF09861 superfamily⁠, 19 LarA sequences reported by [15]⁠ (colored in blue) and 7 putative LarA 430 sequences identified in the MAGs reported in this study (colored in red) were aligned using MAFFT 431 v7 (FFT-NS-2 strategy)[85]⁠. The alignment output was used to construct an approximately-maximum- 432 likelihood phylogenetic tree using FastTree v2.1.11 with default parameters [86]⁠. 433 434 435 436 437 438

12 439 Description of Supplementary Tables 440 441 Table S1: List and description of genomes (complete, MAGs and SAGs) used in the study 442 443 Table S2: List of archaeal single copy marker genes from Rinke et al. 2013 used in the concatenated 444 alignment for the generation of the phylogenomic tree in Fig. 2. 445 446 Table S3: Description of protein families generated from the dataset. 447 448 Table S4: Locus tags and associated annotation of central metabolic pathways of the MAGs reported 449 in this study. 450 451 452 453 References 454 455 1. Zhao R, Hannisdal B, Mogollon JM, Jørgensen SL. Nitrifier abundance and diversity peak at 456 deep redox transition zones. Sci Rep 2019; 9: 1–12. 457 2. Nunoura T, Takaki Y, Kazama H, Hirai M, Ashi J, Imachi H, et al. Microbial Diversity in 458 Deep-sea Methane Seep Sediments Presented by SSU rRNA Gene Tag Sequencing. Microbes 459 Environ 2012; 27: 382–390. 460 3. Hirai M, Nishi S, Tsuda M, Sunamura M, Takaki Y, Nunoura T. Library construction from 461 subnanogram DNA for pelagic sea water and deep-sea sediments. Microbes Environ 2017. 462 4. Zhao R, Dahle H, Ramírez GA, Jørgensen SL. Indigenous Ammonia-Oxidizing Archaea in 463 Oxic Subseafloor Oceanic Crust. mSystems 2020; 5. 464 5. Jain C, Rodriguez-R LM, Phillippy AM, Konstantinidis KT, Aluru S. High throughput ANI 465 analysis of 90K prokaryotic genomes reveals clear species boundaries. Nat Commun 2018; 9: 466 5114. 467 6. Konstantinidis KT, Rosselló-Móra R, Amann R. Uncultivated microbes in need of their own 468 taxonomy. ISME J 2017; 11: 2399–2406. 469 7. Kirkpatrick JB, Walsh EA, D’Hondt S. Microbial Selection and Survival in Subseafloor 470 Sediment. Front Microbiol 2019; 10: 956. 471 8. Petro C, Starnawski P, Schramm A, Kjeldsen K. Microbial community assembly in marine 472 sediments. Aquat Microb Ecol 2017; 79: 177–195. 473 9. Orcutt BN, Edwards KJ. Life in the Ocean Crust. Developments in Marine Geology. 2014. pp 474 175–196. 475 10. Abby SS, Melcher M, Kerou M, Krupovic M, Stieglmeier M, Rossel C, et al. Candidatus 476 Nitrosocaldus cavascurensis, an Ammonia Oxidizing, Extremely Thermophilic Archaeon with 477 a Highly Mobile Genome. Front Microbiol 2018; 9: 28. 478 11. Herbold CW, Lehtovirta-Morley LE, Jung M-Y, Jehmlich N, Hausmann B, Han P, et al. 479 Ammonia-oxidising archaea living at low pH: Insights from comparative genomics. Environ 480 Microbiol 2017; 19: 4939–4952. 481 12. Spang A, Poehlein A, Offre P, Zumbragel S, Haider S, Rychlik N, et al. The genome of the 482 ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility

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17 Figure S1

Archaeon_CSP1 NPMR_NP_delta_1NPMR_NP_delta_3NPMR_NP_delta_2NPMR_NP_theta_4NPMR_NP_theta_3YK1312_12N_NP_thetaNPMR_NP_theta_2NPMR_NP_theta_1NPMR_NP_theta_5NPMR_NP_iota_1YK1309_1N_NP_iota

Archaeon_CSP1

NPMR_NP_delta_1

NPMR_NP_delta_3

NP-delta NPMR_NP_delta_2

NPMR_NP_theta_4

NPMR_NP_theta_3

YK1312_12N_NP_theta

NPMR_NP_theta_2 Percentage

NP-theta NPMR_NP_theta_1

NPMR_NP_theta_5

NPMR_NP_iota_1

YK1309_1N_NP_iota NP-iota

Figure S2 NP-delta NP-theta NP-iota Tree scale: 1

Glyoxylate/hydroxypyruvate reductases B

3-phosphoglycerate dehydrogenases D-lactate dehydrogenases

Glyoxylate/hydroxypyruvate reductases C

C-terminal binding proteins

Broad-substrate-specificity dehydrogenases

Glyoxylate/hydroxypyruvate reductases C

4-phosphoerythronate dehydrogenases

sau SA0171 fdh formate dehydrogenase EC 1.2.2.1 Candidatus Nitrososphaera evergladensis SR1 AIF84254.1 Candidatus Nitrosocosmicus oleophilus ALI34306.1 Candidatus Nitrosocosmicus exaquare CP017922.1 704 Candidatus Nitrososphaera evergladensis SR1 AIF84253.1 UBA348 DAOM01000320.1 5 RRmetagenome bin19 PWU79169.1 sp Q9S7E4 FDH ARATH Formate dehydrogenase ath AT5G14780 FDH formate dehydrogenase osa 4341069 Os06g0486800 osa 4341070 Os06g0486900 ang ANI 1 76134 An15g00410 formate dehydrogenase sp G0SGU4 FDH CHATD Formate dehydrogenase OS Chaetomium thermophilum strain DSM 1495 sp O13437 FDH CANBO Formate dehydrogenase OS Candida boidinii GN FDH1 PE 1 SV 1 tr A0A0A1EQY0 A0A0A1EQY0 CANBO Formate dehydrogenase OS Candida boidinii GN FDH PE 1 SV 1 sce YOR388C FDH1 formate dehydrogenase NAD EC 1.2.1.2 Formate sp Q08911 FDH1 YEAST Formate dehydrogenase 1 OS Saccharomyces cerevisiae strain ATCC 204508 bpe BP1513 formate dehydrogenase EC 1.2.2.1 dehydrogenases tr G8NVB5 G8NVB5 GRAMM Formate dehydrogenase OS Granulicella mallensis strain ATCC BAA-1857 sme SMa0478 formate dehydrogenase EC 1.2.2.1 tr O08375 O08375 MORSP Formate dehydrogenase OS Moraxella sp. GN fdh PE 1 SV 1 sp P33160 FDH PSESR Formate dehydrogenase OS Pseudomonas sp. strain 101 PE 1 SV 3 tr Q76EB7 Q76EB7 9PROT Formate dehydrogenase OS Thiobacillus sp. KNK65MA GN fdh65MA PE 1 SV 1 NPMR_NP_iota_1 v2 620001 YK1309_1N_NP_iota c 000001178250 2 NPMR_NP_theta_3 v2 710007 YK1312_12N_NP_theta c 000000134335 1 c 000000355105 2 lpn lpg0283 formate dehydrogenase EC 1.2.2.1 og1 GWHAAAX00000003 14 og2 GWHAAAW00000009 27 Marine Group I thaumarchaeote SCGC AB-629-I23 ARWQ01000001.1 171 SCGC AAA007-O23 2527291526 33

Figure S3 Non-AOA NC-alpha NS-zeta NS-alpha NP-epsilon NP-gamma NS-gamma NP-delta NT-alpha NP-eta NP-iota NP-theta NP-alpha Figure S4 Ca. Nitrososphaera evergladensis SR1 evergladensis Ca. Nitrososphaera a irssheagressGa9.2 gargensis Nitrososphaera Ca. Ca. Nitrosopumilus koreensis koreensis Ca. Nitrosopumilus AR1 Nitrosotenuis chungbukensis MY2 chungbukensis Nitrosotenuis Ca. Nitrosocosmicus franklandus Ca. Nitrosocosmicus Nitrososphaera viennensis EN76 viennensis Nitrososphaera Nitrosoarchaeum koreensis MY1 koreensis Nitrosoarchaeum Ca. Nitrosocaldus cavascurensis Ca. Nitrosocaldus Nitrosopumilus maritimus SCM1 maritimus Nitrosopumilus Ca. Nitrosocosmicus oleophilus Ca. Nitrosocosmicus Ca. Nitrosocosmicus exaquare Ca. Nitrosocosmicus Nitrosotalea okcheonensis CS okcheonensis Nitrosotalea Nitrosoarchaeum limnia BG20 limnia Nitrosoarchaeum Nitrosoarchaeum limnia SFB1 limnia Nitrosoarchaeum Ca. Nitrosopumilus piranensis Ca. Nitrosopumilus Ca. Nitrosopumilus adriaticus Ca. Nitrosopumilus Ca. Nitrosopumilus sediminis Ca. Nitrosopumilus CG 4 9 14 0 2 um filter 34 16 CG 491402umfilter34 Nitrosocosmicus arcticus Kfb arcticus Nitrosocosmicus Ca. Nitrosotalea devanaterra Ca. Nitrosotalea Nitrosopumilus salaria BD31 salaria Nitrosopumilus Ca. Nitrosocaldus islandicus Ca. Nitrosocaldus Cenarchaeum symbiosum symbiosum Cenarchaeum A Ca. Nitrosomarinus catalina Ca. Nitrosomarinus Nitrosopumilus strainDDS1 Nitrosopumilus Nitrosotenuis uzonensis N4 uzonensis Nitrosotenuis Ca. Nitrosopelagicus brevis Ca. Nitrosopelagicus Nitrosotalea bavarica SbT1 bavarica Nitrosotalea Ca. Nitrosotenuis aquarius Ca. Nitrosotenuis Ca. Nitrosotenuis cloacae Ca. Nitrosotenuis Nitrosotalea sinensis Nd2 sinensis Nitrosotalea Nitrosopumilus sp.NM25 Nitrosopumilus YK1312_12N_NP_theta RRmetagenome bin19 RRmetagenome Nitrosopumilus spSJ Nitrosopumilus YK1309_1N_NP_iota SCGC AAA799-N04 SCGC AAA799-E16 SCGC AAA799-D11 NPMR_NP_theta_5 NPMR_NP_theta_1 NPMR_NP_theta_2 NPMR_NP_theta_3 NPMR_NP_theta_4 NPMR_NP_delta_2 NPMR_NP_delta_3 NPMR_NP_delta_1 SCGC AB-629-I23 13 1 40CM 4387 13 140CM 13 1 40CM 3386 13 140CM NPMR_NP_iota_1 13 1 40CM 3812 13 140CM Archaeon CSP1 Archaeon md1 -D11 MAG og1 SAG -G13 og1 SAG og2 SAG -F20 og2 SAG casp-thauma3 casp-thauma1 AAA007-O23 ma1 - T1 L11 SCGC RSA3 mg4 - T3L15 ma7 - T3L14 ma8 - T3L19 palsa 1368 mg3 -D17 Baikal-G2 bog 1369 bog 1367 ma2 -D1 NORP47 UBA141 UBA219 UBA223 UBA218 UBA201 UBA348 UBA536 UBA213 UBA459 EAC691 SAT139 SAT137 NP142 J079

nit2 ureA N-metabolism m co1 larA fdh pgi putA/proDH rocA oat ggt kal C/AA metabolim kat argD serC ilvA ilvE aspC gcvTPH m etH m etE pepB pepN pepF M10 Proteases AprE Sto/Pro zincin

Do Figure S2 PP2A APC ZIP SSS-Urea DAACS ArsB SBT CUT1 Transport CUT2 HAAT PhnT PiT PhoT QAT BCCT tbp rpoS54 polD2 uvrABC hef phr Information processing / udg4 udg5 DNA repair m pg alkA ogg1 tag endoV POP4 uspA pcm Cell maintenance MIP m scL m scS proP nhaP Osmotic regulation Trk ectC ipct/dipps cspC Thermoadaptation cshA LLM Detoxification nanM A-type_ATPase HHP adaptation V-t y p e_ATPase flaK Motility - Fla flaI/TadC Motility - Pili cheAB cheY Chemotaxis xerD/xerC Mobilome > = 1 6 2 3 4 5

Number of proteins 54 68 Gster_LDH 1 MKNNGG--ARVVVIGA-GFVGASYVFALMNQGIADEIVLIDANESKAIGDAM--DFNHGKVFAP--KPVDI-WHGDYDDC Tth_LDH 1 ------MKVGIVGS-GMVGSATAYALALLGVAREVVLVDLDRKLAQAHAE--DILHATPFA---HPVWVRA-GSYGDL Blon_LDH 1 MAETTVKPTKLAVIGA-GAVGSTLAFAAAQRGIAREIVLEDIAKERVEAEVL--DMQHGSSFY---PTVSIDGSDDPEIC Ctep_MDH 1 ------MKITVIGA-GNVGATTAFRLAEKQLARELVLLDVVEGIPQGKAL--DMYESGPVGL--FDTKVTGSNDYADT Nvie_MDH 1 ------MTITVIGS-GKVGASAALNCGLRELDD-ILLLDIVQGLPQGEAM--DINHQLSERG--SDSVARGSNNYEDM Nmar_MDH 1 ------MITIIGS-GKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAM--DINHMLSEQG--IDVEVKGSNNFEDM Nkor_MDH 1 ------MITIIGS-GKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAM--DINHMLSEQG--IDVEVKGSSNFEDM NPMRtheta1_MDH 1 ------MITIIGA-GKVGGGAALFSALRNLDDQILLLDIVEGLPQGEAM--DINHALSEQG--IDVEIKGSNDYSDM NPMRtheta5_MDH 1 ------MITIIGA-GKVGGGAALFSALRNLDDQILLLDIVEGLPQGEAM--DINHALSEQG--IDVEIKGSNDYSDM NPMRtheta2_MDH 1 ------VITIIGA-GKVGGDAALFSALRNLDDQILLLDIVKGLPQGEAM--DINHALSEQG--IDVEIKGSNDYSDM YK1312theta_MDH 1 ------MITIIGA-GKVGGEAALFSALKKLDDQILLLDIIEGLPQGEAM--DINHMLSEQG--IDVEVKGSNDYSDM NPMRtheta4_MDH 1 ------MITIIGA-GKVGGDAALFSALKKLDNQILLLDIIEGLPQGEAM--DINHTLSEQG--IDVDIKGSNDYSDM Nbrev_MDH 1 ------MITIIGA-GKVGGDAALFSALRRLDDEILLLDIAEGLPQGEAM--DLNHMLSEQG--IDVNVKGSNNYEDM NPMRdelta3_MDH 1 ------MITIIGS-GKVGGAAALFTALKKLDEQILLLDVVKGLPQGEAM--DLNHALSEQG--VDVEIIGSNDYSDM NPMRdelta2_MDH 1 ------MITIIGS-GKVGGEAALFTALKKLDDQILLLDIVKGLPQGEAM--DLNHSLSELG--IDVEIIGSNDYSDM NPMRiota1_MDH 1 ------MITIVGA-GKVGGAAAISIALRNLSDEILLLDVIKGLPEGEAM--DINHMLSEKG--INVDVRGSNDYSDI YK1309iota_MDH 1 ------MITIVGA-GKVGGAAAISIALRNLSDEILLLDVIKGLPEGEAM--DINHMLSEKG--INVDVRGSNDYSDI Nuzo_MDH 1 ------MLTIIGS-GKVGGDAALFSALRKVDKDILLLDVVNGLPQGEAM--DLNHMLSEQG--VDVHIRGSNDYADM Mjan_MDH 1 ------MKVTIIGASGRVGSATALLLAKEPFMKDLVLIGREHSINKLEGLREDIYDALAGTRSDANIYVESDENLRII Iisl_MDH 1 MARI---PYKVAVIGT-GRVGATFAYTMAVVPGIARMTLVDVVPGLAKGVME--DIKHAAAVFR--RSITVEAFEDVSKV Msed_MDH 1 M------AKVGFIGA-GKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEH--ELRHAFATKG--IKANVLGTNSLDDV

102 Gster_LDH 73 RDADLVVICAGANQKPGETRLDLVDKNIAIFRSIVESVMASGFQGLFLVATNPVDILTYATWKFSGLPHERVIGSGTILD Tth_LDH 66 EGARAVVLAAGVAQRPGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVDVMTQVAYRLSGLPPGRVVGSGTILD Blon_LDH 75 RDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKLTGLPENQIFGSGTNLD Ctep_MDH 68 ANSDIVVITAGLPRKPGMTREDLLSMNAGIVREVTGRIMEHSKNPIIVVVSNPLDIMTHVAWQKSGLPKERVIGMAGVLD Nvie_MDH 67 RGSDYVVLVAGVGRKPGMTRMDLLKINAGIVKDVASKIATYAKDATVIVVTNPLDPMTYLALKTIGAQKSKVMGMGGMLD Nmar_MDH 67 KGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLD Nkor_MDH 67 KGSKIIVVVAGSGRKPGMTRMDLLKINATIVKSVVENIKKYANDSMIIPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLD NPMRtheta1_MDH 67 KGSNIVVVVAGLGRKPGMTRMDLLQKNAGIVKSVVENIKKYADNSMIIPVTNPLDPMTYICYKVSGFERNRVFGMGGMLD NPMRtheta5_MDH 67 KGSNIVVVVAGLGRKPGMTRMDLLQKNAGIVKSVVENIKKYADDSMIIPVTNPLDPMAYICYKVSGFERNRVFGMGGMLD NPMRtheta2_MDH 67 KGSNIVVVVAGLGRKPGMTRMDLLQKNAGIVKSVVENIKKYADDSIIIPVTNPLDPMTYICYKVSGFERNRVFGMGGMLD YK1312theta_MDH 67 KGSDIVVTVAGSGRKPGMTRMDLLKINAGVVKSVVENIKKYANDAMIIPVTNPLDPMAYICYKVSGFEKNRIFGMGGMLD NPMRtheta4_MDH 67 KGSDIVVVVAGLGRKPGMTRMDLLQKNAGIVKSVVENIKKYANDSMIIPVTNPLDPMAHICYKVSGFEKNRVIGMGGMLD Nbrev_MDH 67 KGSKIVVVVAGAGRKPGMTRMDLLKINAGVVKDVVGNIKKFADDAMIIPVTNPLDPMAQIAYKTSGFDRSRVFGMGGMLD NPMRdelta3_MDH 67 KDSKIVVIVAGSGRKPGMTRMDLLKINAGVVKDVVENIKKYSNDAILVPVTNPLDPMAHIAYKTSGFERNRILGMGNMLD NPMRdelta2_MDH 67 KNSKIVVVVAGSGRKPGMTRMDLLKINAGVVKDVVENIKKYSKDSFIIPVTNPLDPMAHIAYKVSGFSRNRIFGMGNMLD NPMRiota1_MDH 67 KGSEIVVVVAGSGRKPGMTRMDLLKVNASVVKDVTENIKKYANNSIIVPVTNPLDPMAYVAFKVSGFSKNRIVGMGNMLD YK1309iota_MDH 67 KGSEIVVVVAGSGRKPGMTRMDLLKVNASVVKDVTENIKKYANNSIIVPVTNPLDPMAYVAFKVSGFSKNRIVGMGNMLD Nuzo_MDH 67 KGSDIVVVVAGSGRKPGMTRMDLLKINAGIVKDVVENIKKHASNAIIVPVTNPLDPMVHITYKTSGFEPSRIVGMGNMLD Mjan_MDH 73 DESDVVIITSGVPRKEGMSRMDLAKTNAKIVGKYAKKIAEICDTKIF-VITNPVDVMTYKALVDSKFERNQVFGLGTHLD Iisl_MDH 73 ENADAIVITAGKPRKADMSRRDLANVNAQIIRDIGDKLRDRNPGALYVVVTNPVDVMTMVLDDVIG-SKGTVIGTGTSLD Msed_MDH 69 SGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKY---SKQFTISAGDQVE

171 199 Gster_LDH 153 TARFRFLLGEYFSVAPQNVHAYIIGEHGDTELPVWSQAYIGVMPIRKLVESKGEE--AQKDLERIFVNVRDAAYQIIE-- Tth_LDH 146 TARFRALLAEYLRVAPQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRA-LSPEDRARIDEGVRRAAYRIIE-- Blon_LDH 155 SARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPLWESATIGGVPMCDWTPLPGHDPLDADKREEIHQEVKNAAYKIIN-- Ctep_MDH 148 SARFRSFIAMELGVSMQDVTACVLGGHGDAMVPVVKYTTVAGIPVADL------ISAERIAELVERTRTGGAEIVNHL Nvie_MDH 147 LSRFKSYIQEATGVSRDSIQAMVISEHGENMLPLTRFSSLGGIPLHDF------ITKEQATDIFEKTKKVAAEVIA-- Nmar_MDH 147 LSRFRQFIHEATGHSRDSIRALVIGEHGENMLPLPRFSSVSGIPLPSL------LPKEKLEELVQNTKQVAAKVIE-- Nkor_MDH 147 LSRFRQFIHEATGHSRDSIRALVIGEHGENMLPLPRFSSVSGIPLSSF------LPKQKLDELVQNTKQVAAKVIE-- NPMRtheta1_MDH 147 ISRFKQFIHEATGHSRHSIRALVIGEHGENMLPLPRFSSVSGIPLTSL------LSKEKLDELVQNTRNVAAKVIE-- NPMRtheta5_MDH 147 ISRFKQFIHEATGHSRHSIRALVIGEHGENMLPLPRFSSVSGIPLTSL------LPKEKLDELVQNTRQVAAKVIE-- NPMRtheta2_MDH 147 LSRFKQFIHEATGHSRHSIRALVIGEHGENMLPLPRFSSVSGIPLTSL------LSKEKIDELVQNTRQVAAKVIE-- YK1312theta_MDH 147 ISRFIQFIHEATGHSRDSIRALVIGEHGENMLPLPRFSSVSGIPLTSL------LSKEKLDELVQNTKQVAAKVIE-- NPMRtheta4_MDH 147 LSRFKQFIHEATGYSRDSIRALVIGEHGENMLPLPRFSSVAGIPLVSL------LSKEKLDELIQNTRQIAAKVIE-- Nbrev_MDH 147 LSRFKQFIHEATGYSRESTKALVIGEHGENMLPLTRFATVSGIPLPTL------LPKEKLDEIFTATKGVAAEVIK-- NPMRdelta3_MDH 147 LSRFSQFIHEATGQSRESIRALVIGEHGENMLPLIRFSSVSGIPLTSL------LAKDKLEELEKNTRQVAAKVIE-- NPMRdelta2_MDH 147 ISRFTQFIHEATGYSRQSIRALVIGEHGENMLPLMRFSSVSGIPLTSL------LSKEKLDELEKNTRQVAAKVIE-- NPMRiota1_MDH 147 LSRFKQFIHESTGFSRDSIRALVIGEHGENMVPLPRFSSVAGIPLMSL------LSKEKIDELVVSTREVAAKVIE-- YK1309iota_MDH 147 LSRFKQFIHESTGFSRDSIRALVIGEHGENMVPLPRFSSVAGIPLMSL------LPKEKIDELVISTREVAAKVIE-- Nuzo_MDH 147 LSRFIQFIHESTGHSRDSIRALVIGEHGENMLPLPRFSTVSGIPLASI------LPKEKLDQIVKDTRGVAAKVIE-- Mjan_MDH 152 SLRFKVAIAKFFGVHIDEVRTRIIGEHGDSMVPLLSATSIGGIPIQKFER------FKELPIDEIIEDVKTKGEQIIR-- Iisl_MDH 152 TFRFRAAVSELLNVPIVAVDGYVVGEHGEEAFVAWSTVTIKGIHIDQYIKERNIN-ISR---EQIEKYVKDVAASIIA-- Msed_MDH 146 TMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFN------INK---DEVSDYVKKIPGEIIR-- 246 Gster_LDH 229 KKGATYYGIAMGLARVTRAILHNENAILTVSAYLDGLY-GERDVYIGVPAVINRNGIREVIEIELNDDEKNRFHHSAATL Tth_LDH 223 GKGATYYGIGAGLARLVRAILTDEKGVYTVSAFTPEVE-GVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEIL Blon_LDH 233 GKGATNYAIGMSGVDIIEAVLHDTNRILPVSSMLKDFH-GISDICMSVPTLLNRQGVNNTINTPVSDKELAALKRSAETL Ctep_MDH 220 KQGSAFYAPATSVVEMVESIVLDRKRVLTCAVSLDGQY-GIDGTFVGVPVKLGKNGVEHIYEIKLDQSDLDLLQKSAKIV Nvie_MDH 217 LKGATVYAPGNAVATMIESMAKDKKMVIPVSAYLDGQY-GVSDLCIGVPAVIGAGGVEKIVELKLDSFEQGVFDKGVASV Nmar_MDH 217 LKGATVHAPGNAISAIVEAVVRDRKQVIPVATYLDGEY-DHSDVTIGVPAVIGKNGVEKIIELDLNDEEKQVFNKAVENV Nkor_MDH 217 LKGATVHAPGNAISAMIEAVVRDRKQVIPVATYLDGEY-GHSDVTIGVPAVIGKKGVEKIIELDLNAEEKQLFDAGIQNV NPMRtheta1_MDH 217 LKGATVHAPGNGISAIIDSVVNDKKQVLPIATYLDGEY-GYSDVTIGVPAVIGKNGVEKIIELDLNDEEKEMFNKGIESV NPMRtheta5_MDH 217 LKGATIHAPGNGISAIIDSVVNDKKQVLPIATYLDGEY-GYSDVTIGVPAVIGKNGVEKIIELDLNDEEKEMFNKGIESV NPMRtheta2_MDH 217 LKGATVHAPGNGISTIIDSVVNGKMQVLPIATYLDGEY-GYSDVTIGVPAVIGKNGVEKIIELDLNDEEKEIFNKGIESV YK1312theta_MDH 217 LKGATIHAPGNGISSIIDAVVNNRKRVIPVATYLDGEY-GYSDVTIGVPAVVGRNGVEKIVELDLNDEEKSMFQKGIESI NPMRtheta4_MDH 217 LKGATIHAPGNGISAIIDSIVNNRKQVLPVATCLDGEY-GQSDITIGVPAVVGKKGIEKIIELDLNEEEKDWFNKGIVSV Nbrev_MDH 217 LKGATVHAPGNAISAMIESVVQDKKQVIPVSTNLDGEY-GQKDVSIGVPAVVGKKGVEKILELELNDEEKEWFNKGVDSV NPMRdelta3_MDH 217 LKGATIHAPGNAISSIIESVVRDKKRVMPVSTPLNGEY-GYSDVTVGVPAVIGKNGVEKIIELELNDEEKDWFRKSVDSV NPMRdelta2_MDH 217 LKGATVHAPANAISSIIESVVRNQRRIIPVATPLDGEY-GYSDVTIGVPAVVGKNGVEKIIQLDLDEKEKEWIKKSVESV NPMRiota1_MDH 217 LKGATVHAPANGISAIVESIVRDTKQVIPVATYLDGEY-GFSDVTIGVPAVVGKNGIEKIIELDLDSSEKE------YK1309iota_MDH 217 LKGATVHAPANGISVIVESIVRDTKQVIPVATYLDGEY-GFSDVTIGVPAVVGKNGIEKIIELDLDSSEKEWFKKGVDSV Nuzo_MDH 217 LKGATVHAPGNAISAIVEAIIKDRKKVIPVATPLTGQY-GHSDVSIGVPAVIGRKGVEKIIELDLNSEEKEWFEKGVNSV Mjan_MDH 224 LKGGSEFGPAAAILNVVRCIVNNEKRLLTLSAYVDGEFDGIRDVCIGVPVKIGRDGIEEVVSIELDKDEIIAFRKSAEII Iisl_MDH 226 SQGATIWGPAATFQEIVVSHLANESKIIPISLPQNIE--GVGRVAVSVPTIISGR-LKPLVQL-LNEEEQERLKRAAKAI Msed_MDH 214 VIGGTTWGPGTIIADIIKSIAFSENRVMSIATP--KEY-EKEIIHVSAPTVVGSS-IGPSLESLLDEKDRWHLNSAMKDF

Fig. S5. Sequence alignment of lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) homologs, shaded in yellow and green, respectively. Conserved residues are shaded in black and grey. The universally conserved in the LDH/MDH superfamily substrate binding Arg171 is indicated in red. Residues important for substrate discrimination and active site architecture are shaded in orange and discussed in the text. The residue determining the cofactor specificity is shaded in green. Residue numbering refers to the LDH numbering as in Roche et al. 2019. Primary sequences from the following organisms were used to generate the alignment (Uniprot accession numbers in parentheses): Gster, Geobacillus stearothermophilus (P00344); Tth, Thermus thermophilus (Q5SJA1); Blon, Bifidobacterium longum (E8ME30); Ctep, Chlorobaculum tepidum (P80039); Nvie, Nitrososphaera viennensis (A0A060HG74); Nmar, Nitrosopumilus maritimus (A9A450); Nkor, Nitrosarchaeum koreense (F9CUM5); Nbrev, Ca. Nitrosopelagicus brevis (A0A0A7V4F4); Nuzo, Ca. Nitrosotenuis uzonensis (V6AR53); Mjan, Methanocaldococcus jannaschii (Q60176); Iisl, Ignicoccus islandicus (A0A0U3FQH7); Msed, Metallosphaera sedula (A4YDY0). Sequences from the marine sediment AOA MAGs reported in this study are in bold and their locus tags can be found in Table S3. Tree scale: 10

Colored ranges Putative LarA from sediment AOA

LactobacillusLactobacillus diolivorans acidifarinae DSM DSM 14421@Protein 19394@Protein LarA@GeneID LarA@GeneID FC85 FD25 RS02285 RS12270 Desguin2017 Desguin2017 LarA sequences Lactobacillus farraginis DSM 18382@Protein LarA@GeneID FD41 RS00695 Desguin2017

tr|G7W825|G7W825 DESOD@Lar N domain-containing protein@OS=Desulfosporosinus orientis strain ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628@GN=Desor 0768

tr|J7IVV8|J7IVV8 DESMD@Lar N domain-containing protein@OS=Desulfosporosinus meridiei strain ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10@GN=Desmer 0789

tr|A0A133SKE1|A0A133SKE1 9FIRM@Putative septum site-determining protein MinC@OS=Megasphaera sp. MJR8396C@GN=HMPREF3201 00410

tr|A0A1I2EB23|A0A1I2EB23 9FIRM@Nickel-dependent lactate racemase@OS=Succiniclasticum ruminis DSM 9236@GN=SAMN05216245 1324

tr|D3PA49|D3PA49 DEFDS@Lar N domain-containing protein@OS=Deferribacter desulfuricans strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1@GN=DEFDS 2142 tr|A0A1M5XTE3|A0A1M5XTE3 9DELT@Nickel-dependent lactate racemase@OS=Desulfofustis glycolicus DSM 9705@GN=SAMN02745124tr|M5DZ12|M5DZ12 9FIRM@Transcriptional 03331 regulator@OS=Halanaerobium saccharolyticum subsp. saccharolyticum DSM 6643@GN=HSACCH 00937

tr|E4TGB4|E4TGB4 CALNY@Lar N domain-containing protein@OS=Calditerrivibrio nitroreducens strain DSM 19672 / NBRC 101217 / Yu37-1@GN=Calni 1796

tr|A0A1M6IQZ3|A0A1M6IQZ3tr|A5I3E3|A5I3E3 CLOBH@Lar 9FIRM@Nickel-dependent N domain-containing lactate protein@OS=Clostridium racemase@OS=Dethiosulfatibacter botulinum strain Hallaminovorans / ATCC 3502 DSM / 17477@GN=SAMN02745751NCTC 13319 / Type A@GN=CBO2019 02400 tr|E8LCY1|E8LCY1 N domain-containing 9FIRM@Lar protein@OS=Phascolarctobacterium succinatutens YIT 12067@GN=HMPREF9443 00704 tr|A0A1H8V9R2|A0A1H8V9R2 9FIRM@Nickel-dependent lactate racemase@OS=Propionispora vibrioides@GN=SAMN04490178 110128 tr|A0A1G9MFF2|A0A1G9MFF2 9FIRM@Nickel-dependent lactate racemase@OS=Halarsenatibacter silvermanii@GN=SAMN04488692 10838

tr|A0A1G9VYZ4|A0A1G9VYZ4 9FIRM@Nickel-dependent lactate racemase@OS=Megasphaera paucivorans@GN=SAMN05660299 01514 tr|A0A1I4MRY6|A0A1I4MRY6 9FIRM@Lar N domain-containing protein@OS=Halanaerobium salsuginis@GN=SAMN02983006 02688

tr|A0A1M5VZN6|A0A1M5VZN6 9DELT@Nickel-dependent lactate racemase@OS=Desulfofustis glycolicus DSM 9705@GN=SAMN02745124 01988 tr|A5I2T6|A5I2T6 CLOBH@Lar N domain-containing protein@OS=Clostridium botulinum strain Hall / ATCC 3502 / NCTC 13319 / Type A@GN=CBO1814 tr|A0A1Y4CTJ5|A0A1Y4CTJ5 9FIRM@Lar N domain-containing protein@OS=Megasphaera sp. An286@GN=B5F80 00370 tr|L0F728|L0F728 DESDL@Lar N domain-containingtr|A0A1M6NR64|A0A1M6NR64 protein@OS=Desulfitobacterium 9CLOT@Nickel-dependent lactatedichloroeliminans racemase@OS=Geosporobacter strain LMG P-21439 subterraneus / DCA1@GN=Desdi DSM 17957@GN=SAMN02745975 1493 03367 tr|A0A1I2EAU9|A0A1I2EAU9 9FIRM@Nickel-dependent lactate racemase@OS=Succiniclasticum ruminis DSM 9236@GN=SAMN05216245 1325 tr|A0A0H3JAX8|A0A0H3JAX8 CLOPA@Lar N domain-containing protein@OS=Clostridium pasteurianum DSM 525 = ATCC 6013@GN=CLPA c39300 tr|A0A0J6ZQ56|A0A0J6ZQ56 9FIRM@Lar N domain-containing protein@OS=Megasphaera cerevisiae DSM 20462@GN=AB840 04630

tr|A0A1W1XRZ2|A0A1W1XRZ2 9CLOT@Nickel-dependent lactate racemase@OS=Clostridiumtr|A0A1G5I1E6|A0A1G5I1E6 9CLOT@Nickel-dependentacidisoli DSM 12555@GN=SAMN02745134 lactate racemase@OS=Alkaliphilus peptidifermentans 02768 DSM 18978@GN=SAMN03080606 02207 tr|I4BYR0|I4BYR0 ACEMN@Lar N domain-containing protein@OS=Acetomicrobium mobile strain ATCC BAA-54 / DSM 13181 /tr|A0A1M6MNB5|A0A1M6MNB5 JCM 12221tr|A0A1G9SWC6|A0A1G9SWC6 tr|A0A1J0GGD3|A0A1J0GGD3/ NGA@GN=Anamo 9CLOT@Nickel-dependent 9FIRM@Nickel-dependent 9CLOT@Lar 1831 lactate N domain-containing racemase@OS=Paramaledivibacter lactate racemase@OS=Dendrosporobacter protein@OS=Clostridium estertheticum caminithermalis quercicolus@GN=SAMN04488502 subsp. DSM estertheticum@GN=A7L45 15212@GN=SAMN02745912 104136 10330 01336 tr|A6LSU3|A6LSU3 CLOB8@Lar N domain-containing protein@OS=Clostridiumtr|D9QR49|D9QR49 beijerinckii ACEAZ@Lar strain N domain-containingATCC 51743 protein@OS=Acetohalobium / NCIMB 8052@GN=Cbei arabaticum 1241 strain ATCC 49924 / DSM 5501tr|A0A259UEU9|A0A259UEU9 / Z-7288@GN=Acear 9FIRM@Lar N domain-containing protein@OS=Sporomusa 1480 acidovorans DSM 3132@GN=SPACI 41540 tr|D9S157|D9S157 THEOJ@Lar N domain-containing protein@OS=Thermosediminibacter oceani strain ATCC BAA-1034 / DSM 16646tr|A0A1M5Y729|A0A1M5Y729 / JW/IW-1228P@GN=Toce 9FIRM@Nickel-dependent lactate racemase@OS=Desulfosporosinus 2224 lacus DSM 15449@GN=SAMN02746098 02314 tr|I4D2J2|I4D2J2 DESAJ@Lar N domain-containing protein@OS=Desulfosporosinus acidiphilus strain DSM 22704 / JCM 16185 / SJ4@GN=Desaci 0971

tr|A0A1G9Z3U5|A0A1G9Z3U5 9FIRM@Nickel-dependent lactate racemase@OS=Dendrosporobacter quercicolus@GN=SAMN04488502 11310 tr|M1MT13|M1MT13 9CLOT@Lar N domain-containing protein@OS=Clostridium saccharoperbutylacetonicum N1-4HMT@GN=Cspa c41030

tr|A0A1W2ELM3|A0A1W2ELM3 9FIRM@Nickel-dependent lactate racemase@OS=Sporomusa malonica@GN=SAMN04488500 12640 tr|A0A0T5XA21|A0A0T5XA21tr|A0A1H0LD88|A0A1H0LD88tr|F8E3P2|F8E3P2 9BACT@Lar N FLESM@Lar domain-containing 9DELT@Nickel-dependent N domain-containing protein@OS=Acetomicrobium lactateprotein@OS=Flexistipes racemase@OS=Desulforhopalus hydrogeniformans sinusarabici strain ATCC singaporensis@GN=SAMN05660330 DSM BAA-1850@GN=HMPREF1705 4947 / MAS 10@GN=Flexsi 0638 00762 04289 tr|A0A1U7MBH5|A0A1U7MBH5 9FIRM@Lar N domain-containing protein@OS=Sporomusa sphaeroides DSM 2875@GN=SPSPH 42070 tr|A0A259UQ52|A0A259UQ52 9FIRM@Lar N domain-containing protein@OS=Sporomusa acidovorans DSM 3132@GN=SPACI 25600

tr|D4H3V0|D4H3V0 DENA2@Lar N domain-containing protein@OS=Denitrovibrio acetiphilus strain DSM 12809 / N2460@GN=Dacet 2441 tr|A0A259URM0|A0A259URM0 9FIRM@Lar N domain-containing protein@OS=Sporomusa silvacetica DSM 10669@GN=SPSIL 16240 tr|A0A0B3W3J0|A0A0B3W3J0 9FIRM@Lar N domain-containing protein@OS=Terrisporobacter othiniensis@GN=QX51 10855 tr|A0A1M4SX08|A0A1M4SX08 9FIRM@Nickel-dependent lactate racemase@OS=Schwartzia succinivorans DSM 10502@GN=SAMN02745190 00282 tr|U5MQQ0|U5MQQ0 CLOSA@Lar N domain-containing protein@OS=Clostridium saccharobutylicum DSM 13864@GN=CLSA c21500 tr|A0A1U7MD94|A0A1U7MD94 9FIRM@Lar N domain-containing protein@OS=Sporomusa sphaeroides DSM 2875@GN=SPSPH 35200 tr|A0A1X7ILL8|A0A1X7ILL8 9BACT@Nickel-dependent lactate racemase@OS=Dethiosulfovibrio salsuginis@GN=SAMN06275492 10363 tr|A0A1Y4CRR1|A0A1Y4CRR1 9FIRM@Lar N domain-containing protein@OS=Megasphaera sp. An286@GN=B5F80 00440

tr|A0A1I4GMY0|A0A1I4GMY0tr|A0A161X532|A0A161X532tr|A0A162R3X8|A0A162R3X8 9FIRM@Nickel-dependent 9CLOT@Lar 9CLOT@Lar lactate N racemase@OS=Halanaerobiumdomain-containing N domain-containing protein@OS=Clostridium protein@OS=Clostridium salsuginis@GN=SAMN02983006 magnum magnum DSM DSM 2767@GN=CLMAG 2767@GN=CLMAG 00814 55510 52890 tr|G0VR80|G0VR80 MEGEL@Lar N domain-containing protein@OS=Megasphaera elsdenii DSM 20460@GN=MELS 0101

tr|V4KSA3|V4KSA3 9DELT@Lar N domain-containing protein@OS=uncultured Desulfofustis sp. PB-SRB1@GN=N839 06645 tr|E7GGQ3|E7GGQ3 CLOSY@Lar N domain-containing protein@OS=tr|A0A0D2J6J9|A0A0D2J6J9 symbiosum 9DELT@Lar WAL-14163@GN=HMPREF9474 N domain-containing protein@OS=Dethiosulfatarculus 00096 tr|A0A1W1ZQV0|A0A1W1ZQV0sandiegensis@GN=X474 9FIRM@Nickel-dependent lactate 12900 racemase@OS=Sporomusa malonica@GN=SAMN04488500 104125 tr|W0EB80|W0EB80 9FIRM@Lar N domain-containing protein@OS=Desulfitobacterium metallireducenstr|A0A1U7MBP6|A0A1U7MBP6 DSM 15288@GN=DESME 9FIRM@Lar N domain-containing protein@OS=Sporomusa14015 sphaeroides DSM 2875@GN=SPSPH 36770 tr|A0A1F4RHK9|A0A1F4RHK9 9BACT@Lar N domain-containing protein@OS=candidate division KSB1 bacterium RBG 16 48 16@GN=A2V82 06340 tr|A0A0D2K1U1|A0A0D2K1U1 9DELT@Lar N domain-containing protein@OS=Dethiosulfatarculus sandiegensis@GN=X474 03180 tr|A0A1G7LWB3|A0A1G7LWB3 9DELT@Nickel-dependent lactate racemase@OS=Desulfovibrio legallii@GN=SAMN05192586 10753tr|A0A1U7MHG8|A0A1U7MHG8 9FIRM@Lar N domain-containing protein@OS=Sporomusa sphaeroides DSM 2875@GN=SPSPH 05230 tr|D5ECT9|D5ECT9 AMICL@Lar N domain-containing protein@OS=Aminobacterium colombiense strain DSM 12261tr|A0A151AM50|A0A151AM50 / ALA-1@GN=Amico 9CLOT@Lar 0225 N domain-containing protein@OS=Clostridium colicanis DSM 13634@GN=CLCOL 17380 tr|A0A1W2AP95|A0A1W2AP95 9FIRM@Nickel-dependent lactate racemase@OS=Sporomusa malonica@GN=SAMN04488500 10620 tr|A0A259UW35|A0A259UW35 9FIRM@Lar N domain-containing protein@OS=Sporomusa acidovorans DSM 3132@GN=SPACI 14100

tr|K6TCQ3|K6TCQ3 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. Maddingley MBC34-26@GN=A370 00681 tr|F7NIW6|F7NIW6 9FIRM@Lar N domain-containing protein@OS=Acetonema longum DSM 6540@GN=ALO 10094 tr|Q7MSU0|Q7MSU0 WOLSU@Lartr|A0A1F5CSX6|A0A1F5CSX6 N domain-containing protein@OS=Wolinella 9ARCH@Lar N domain-containing succinogenes strainprotein@OS=Candidatus ATCC 29543tr|A0A1I2A7U0|A0A1I2A7U0 / DSM Bathyarchaeota 1740 / LMG 9FIRM@Nickel-dependent 7466archaeon / NCTC RBG 11488 16 lactate48 13@GN=A3K70/ FDCracemase@OS=Succiniclasticum 602W@GN=WS0140 00570 ruminis DSM 9236@GN=SAMN05216245 10583 tr|A0A0K8JB30|A0A0K8JB30 9FIRM@Lar N domain-containing protein@OS=Propionispora sp. 2/2-37@GN=P22 0751 tr|A0A0J1FE75|A0A0J1FE75 9FIRM@Lar N domain-containing protein@OS=Peptococcaceaetr|A0A259UET4|A0A259UET4 bacterium 9FIRM@Lar CEB3@GN=CEB3 N domain-containing protein@OS=Sporomusa c22580 silvacetica DSM 10669@GN=SPSIL 37470 tr|D2Z5Z3|D2Z5Z3 9BACT@Lar N domain-containingtr|C6PT35|C6PT35 protein@OS=Dethiosulfovibrio 9CLOT@Lar N domain-containing protein@OS=Clostridium peptidovorans DSM carboxidivorans 11002@GN=Dpep P7@GN=CcarbDRAFT 0864 1952 tr|A1HLY5|A1HLY5 9FIRM@Lar N domain-containing protein@OS=Thermosinus carboxydivorans Nor1@GN=TcarDRAFT 2526 tr|E4RNI7|E4RNI7 HALHG@Lar N domain-containing protein@OS=Halanaerobium hydrogeniformans@GN=Halsa 0022tr|A0A1W2EEH6|A0A1W2EEH6 9FIRM@Nickel-dependent lactate racemase@OS=Sporomusa malonica@GN=SAMN04488500 12393 tr|Q747H1|Q747H1 GEOSL@Lar N domain-containing protein@OS=Geobacter sulfurreducenstr|A0A154BW33|A0A154BW33 strain ATCC 51573 ANASB@Lar / DSM N domain-containing 12127 / PCA@GN=GSU3295 protein@OS=Anaerosporomusa subterranea@GN=AXX12 00860 tr|A0A1Y4J5T7|A0A1Y4J5T7 9FIRM@Lar N domain-containing protein@OS=Gemmiger sp. An194@GN=B5F28 05225

tr|D5EFL4|D5EFL4 AMICL@Lar N domain-containing protein@OS=Aminobacterium colombiense strain DSM 12261 / ALA-1@GN=Amico tr|A0A154BRP4|A0A154BRP41225 ANASB@Lar N domain-containing protein@OS=Anaerosporomusa subterranea@GN=AXX12 09810 tr|A0A1T5J2H1|A0A1T5J2H1tr|C6PN25|C6PN25 9CLOT@Nickel-dependent 9CLOT@Lar N domain-containing lactate racemase@OS=Maledivibacter tr|D4J6D7|D4J6D7protein@OS=Clostridium 9FIRM@Uncharacterized carboxidivorans halophilus@GN=SAMN02194393 conserved protein@OS=Coprococcus P7@GN=CcarbDRAFTtr|V4J369|V4J369 9DELT@Lar catus N domain-containing GD/7@GN=CC10192 00855 protein@OS=uncultured 10800 Desulfofustis sp. PB-SRB1@GN=N839 00845 tr|A0A1G0ZMS9|A0A1G0ZMS9 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium RIFOXYC12 FULL 60 16@GN=A2498 03100 tr|U7UMD7|U7UMD7 9FIRM@PF09861 family protein@OS=Megasphaera sp. BV3C16-1@GN=HMPREF1250 0688 tr|B6WQC0|B6WQC0 9DELT@Lartr|A0A151AL35|A0A151AL35 N domain-containingtr|A0A0L8EY96|A0A0L8EY96 9CLOT@Lar protein@OS=Desulfovibrio N domain-containing 9CLOT@Lar N domain-containing protein@OS=Clostridium piger ATCC protein@OS=Clostridium 29098@GN=DESPIG colicanis DSM sp. DMHC13634@GN=CLCOL 00244 10@GN=AGR56 0510520920 tr|A0A1Q8BBE8|A0A1Q8BBE8 9CREN@Lar N domain-containing protein Fragment@OS=Crenarchaeota archaeon 13 1 20CM 2 51 8@GN=AUF79tr|W6N704|W6N704 12065 CLOTY@Transcriptionaltr|Q24QM2|Q24QM2 regulator@OS=Clostridium DESHY@Lar N domain-containing tyrobutyricum protein@OS=Desulfitobacterium DIVETGP@GN=CTDIVETGP hafniense 2266 strain Y51@GN=DSY3881

tr|A6TUX2|A6TUX2 ALKMQ@Lar N domain-containing protein@OS=Alkaliphilus metalliredigens strain QYMF@GN=Amettr|A1HP90|A1HP90 9FIRM@Lar N domain-containing 3891 protein@OS=Thermosinus carboxydivorans Nor1@GN=TcarDRAFT 1744 tr|A0A1Y1RFD6|A0A1Y1RFD6 9BACT@Lar N domain-containingtr|K1JG40|K1JG40tr|H3KH56|H3KH56 protein@OS=Candidatus 9BURK@Lar 9BURK@Lar N Ndomain-containing Cloacimonetesdomain-containing protein@OS=Sutterella protein@OS=Sutterella bacterium 4572 wadsworthensis55@GN=B6244 parvirubratr|A0A1V4INP0|A0A1V4INP0 YIT 11816@GN=HMPREF94402 1 59BFAA@GN=HMPREF9465 11480 9CLOT@Nickel-dependent lactate racemase@OS=Clostridium 02096 01821 chromiireducens@GN=larA tr|C0QJV7|C0QJV7tr|A0A1G1A4R1|A0A1G1A4R1 DESAH@Lar N domain-containing 9BACT@Lar protein@OS=Desulfobacterium N domain-containing protein@OS=Lentisphaerae autotrophicumtr|D1PQY6|D1PQY6 strain bacterium ATCC 9FIRM@Lar43914 RIFOXYA12 / DSMN domain-containing 3382 FULLtr|A0A1S8LZP1|A0A1S8LZP1 / 48HRM2@GN=HRM2 protein@OS=Subdoligranulum 11@GN=A2283 9CLOT@Lar N domain-containing 03965 08470 variabile protein@OS=Clostridium DSM 15176@GN=SUBVAR roseum@GN=CROST 06813 34190 tr|F4XDI5|F4XDI5 9FIRM@Lar N domain-containing protein@OS=Ruminococcaceaetr|A0A151AKA3|A0A151AKA3tr|A0A1D8GJ15|A0A1D8GJ15 bacterium 9CLOT@Lar 9CLOT@Lar D16@GN=HMPREF0866 N domain-containing N domain-containing protein@OS=Clostridium protein@OS=Geosporobacter 01906 colicanis ferrireducens@GN=Gferi DSM 13634@GN=CLCOL 15480 22130 tr|R4KA58|R4KA58 CLOPA@Lar N domain-containing protein@OS=Clostridiumtr|A0A1D8GJD7|A0A1D8GJD7 pasteurianum 9CLOT@Lar N domain-containing BC1@GN=Clopa protein@OS=Geosporobacter 4785 ferrireducens@GN=Gferi 16545

tr|Q12XD0|Q12XD0 METBU@Lar N domain-containingtr|A0A1Q7M5R3|A0A1Q7M5R3 protein@OS=Methanococcoides 9CREN@Lar burtonii N domain-containing strain DSM 6242 protein@OS=Crenarchaeota / NBRCtr|E8LGU7|E8LGU7 107633 /9FIRM@Lar OCM archaeon 468 Ntr|B1C5P4|B1C5P4 domain-containing / ACE-M@GN=Mbur13 1 40CM 9FIRM@Lar protein@OS=Phascolarctobacterium3 52 4@GN=AUI95 N domain-containing 0954 04295protein@OS=Anaerofustis succinatutens stercorihominis YIT 12067@GN=HMPREF9443 DSM 17244@GN=ANASTE 02101 00032 tr|A0A0U1KTI7|A0A0U1KTI7 9FIRM@Transcriptional regulator@OS=Sporomusa sp. An4@GN=SpAn4DRAFT 1728 tr|A0A1Q7MQP5|A0A1Q7MQP5 9CREN@Lar N domain-containingtr|A0A1G0MXQ3|A0A1G0MXQ3 protein@OS=Crenarchaeota 9DELT@Lartr|A0A1C7HGH8|A0A1C7HGH8 N domain-containing archaeon 9BURK@Transcriptional 13 protein@OS=Geobacteraceae 1 40CM 3 52 tr|A6TKP7|A6TKP717@GN=AUI97 regulator@OS=Burkholderiales bacteriumALKMQ@Lar 00445 N GWC2 domain-containing bacterium 53 11@GN=A2076 protein@OS=Alkaliphilus YL45@GN=A4V04 14875 metalliredigens 07910 strain QYMF@GN=Amet 0538 tr|A0A1G0M063|A0A1G0M063 9DELT@Lar N domain-containing protein@OS=Geobacteraceae bacterium GWC2 55 20@GN=A2X82 04975 tr|A0A101VBF5|A0A101VBF5 9FIRM@Lar N domain-containing protein@OS=Desulfitibacter sp. BRH c19@GN=APF76 17760 tr|A6TKS3|A6TKS3 ALKMQ@Lar N domain-containing protein@OS=Alkaliphilustr|A0A0N8NU04|A0A0N8NU04 metalliredigens 9CLOT@Lar N domain-containingstrain QYMF@GN=Amet protein@OS=Oxobacter 0564 pfennigii@GN=OXPF 01250 tr|A0A1D9FRU8|A0A1D9FRU8tr|A0A075KG15|A0A075KG15 9CLOT@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Clostridium protein@OS=Pelosinus sp.formicaceticum@GN=BJL90 UFO1@GN=UFO1 3616 20900 tr|B0P6L7|B0P6L7 9FIRM@Lar N domain-containingtr|A0A1S9I2Q7|A0A1S9I2Q7 protein@OS=Anaerotruncus 9CLOT@Lar N domain-containing colihominis protein@OS=Clostridium DSM 17241@GN=ANACOL tepidum@GN=BS638 00394 10630tr|F7NGG5|F7NGG5 9FIRM@Lar N domain-containing protein@OS=Acetonema longum DSM 6540@GN=ALO 05765 tr|D1Y5Z5|D1Y5Z5 9BACT@Lar N domain-containing protein@OS=Pyramidobactertr|W1U3M4|W1U3M4 9FIRM@Lar piscolens N domain-containing W5455@GN=HMPREF7215 protein@OS=Negativicoccus 1198 succinicivorans DORA 17 25@GN=Q612 NSC00207G0002 tr|A0A075KA23|A0A075KA23 9FIRM@Lar N domain-containing protein@OS=Pelosinus sp. UFO1@GN=UFO1 0992 tr|A0A0N7MTY1|A0A0N7MTY1 9BACT@Nickel-dependent lactate racemase@OS=Candidatus Kryptonium thompsoni@GN=JGI4 02182 tr|G7M3F5|G7M3F5 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. DL-VIII@GN=CDLVIII 3716 tr|A0A0B6X041|A0A0B6X041tr|A0A1M6GBL5|A0A1M6GBL5 tr|A0A0C2HM98|A0A0C2HM989BACT@Lartr|A0A212PK97|A0A212PK97 N domain-containing MALRU@Nickel-dependent 9DELT@Lar 9DELT@Nickel-dependent protein@OS=Pyrinomonas N domain-containing lactate racemase@OS=Malonomonaslactate protein@OS=Geoalkalibacter methylaliphatogenes@GN=PYK22 racemase@OS=Geobacter rubra ferrihydriticus sp. DSM DSM 9736@GN=SAMN06269301 5091@GN=SAMN02745165 02724 DSM 17813@GN=GFER 2804 01955 01483 tr|A0A0U1KX38|A0A0U1KX38 9FIRM@Transcriptional regulator@OS=Sporomusa sp. An4@GN=SpAn4DRAFT 3701 tr|L0KZK2|L0KZK2 METHD@Lar N domain-containingtr|A0A1Q7LSP0|A0A1Q7LSP0 protein@OS=Methanomethylovorans 9CREN@Lar N domain-containing hollandica strain protein@OS=Crenarchaeota DSM 15978tr|C9KJX5|C9KJX5 / NBRCtr|A0A161PUH3|A0A161PUH3 9FIRM@Lar 107637 archaeon N/ domain-containingDMS1@GN=Metho 13 1 40CM 9FIRM@Lar protein@OS=Mitsuokella3 53 N 5@GN=AUJ07 domain-containing 1305 multacidaprotein@OS=Thermovenabulum 06875 DSM 20544@GN=MITSMUL gondwanense@GN=ATZ99 03473 13460 tr|R6HQD7|R6HQD7 9FIRM@Lar protein@OS=Phascolarctobacterium N sp. domain-containing CAG

tr|A0A0D8I9C5|A0A0D8I9C5 9CLOT@Lar N domain-containing protein@OS=Clostridium aceticum@GN=CACETtr|A0A0F2JM64|A0A0F2JM64 9FIRM@Transcriptional c28160 regulator@OS=Desulfosporosinus sp. I2@GN=UF75 0092 tr|A0A133U8J9|A0A133U8J9tr|A0A1Q9MRZ0|A0A1Q9MRZ0 9EURY@Lar LOKAC@Lar N domain-containing N domain-containing protein@OS=candidate protein@OS=Lokiarchaeota division MSBL1 archaeon archaeon strain SCGC-AAA259D14@GN=AKJ62 CR 4@GN=RBG13Lokitr|Q39QL7|Q39QL7 tr|A0A096BUY1|A0A096BUY13775 GEOMG@Lactate 00585 racemase@OS=Geobacter 9FIRM@Transcriptional metallireducens regulator@OS=Veillonella strain GS-15 montpellierensis / ATCC 53774 DNF00314@GN=HMPREF0872 / DSM 7210@GN=larA 07905 tr|D0LVN4|D0LVN4 HALO1@Lar N domain-containingtr|B5ECG5|B5ECG5 protein@OS=Haliangium GEOBB@Lactate ochraceum racemase@OS=Geobacter strain DSM 14365 bemidjiensis JCM/ 11303 strain / SMP-2@GN=Hoch Bem / ATCC BAA-1014 6889 / DSM 16622@GN=larAtr|R5XQM9|R5XQM9 9CLOT@Lar N domain-containing protein@OS=Clostridium bartlettii CAG tr|D1B2H8|D1B2H8 SULD5@Lar N domain-containing protein@OS=Sulfurospirillumtr|B9M1P9|B9M1P9 deleyianum GEODF@Lactate strain ATCC 51133racemase@OS=Geobacter / DSM 6946 / 5175@GN=Sdel daltonii strain DSMtr|I8RHU9|I8RHU9 22248 1277 / JCM 9FIRM@Lar 15807 N domain-containing / FRC-32@GN=larA protein@OS=Pelosinus fermentans B4@GN=FB4 3053 tr|A0A1Q6DUB7|A0A1Q6DUB7 9EURY@Nickel-dependent lactatetr|A0A0R1SQW9|A0A0R1SQW9 racemase@OS=Candidatus 9LACO@Lar Methanohalarchaeum N domain-containing protein@OS=Lactobacillusthermophilum@GN=BTN85 diolivorans 0404 DSM 14421@GN=FC85 GL002319 tr|R6HES2|R6HES2 9FIRM@Lar N domain-containing protein@OS=Phascolarctobacterium sp. CAG tr|A0A1V4MI10|A0A1V4MI10 9FIRM@Lar N domain-containing protein Fragment@OS=Firmicutes bacterium ML8 F2@GN=AVO34 14430 tr|R6IEW3|R6IEW3 9FIRM@Lar N domain-containing protein@OS=Phascolarctobacterium sp. CAG

tr|A0A1G0WAT2|A0A1G0WAT2tr|A0A0W7TIW4|A0A0W7TIW4 9BACT@Lar N domain-containing 9EURY@General protein@OS=Lentisphaerae glycosylation pathwaytr|A0A2A5DNQ5|A0A2A5DNQ5 bacterium protein@OS=Candidatus GWF2 38 69@GN=A2X47 9BACT@Lar Methanomethylophilus N domain-containing 13485 sp. protein@OS=Candidatus 1R26@GN=AUQ37 Hydrogenedentes07520 bacterium@GN=COA73 tr|R5SKK9|R5SKK910485 9FIRM@Lar N domain-containing protein@OS=Firmicutes bacterium CAG tr|A0A0M4DL31|A0A0M4DL31 9DELT@Nickel-dependent lactate racemase@OS=Desulfuromonas soudanensis@GN=DSOUD 3351 tr|G2FS52|G2FS52 9FIRM@Lar N domain-containing protein@OS=Desulfosporosinus sp. OT@GN=DOT 2528 tr|A0A1Q9NYH9|A0A1Q9NYH9 9ARCH@Lar N domain-containing protein@OS=Candidatus Heimdallarchaeota archaeon LC 2@GN=HeimC2tr|A0A1U7MAV2|A0A1U7MAV2 12700 9FIRM@Lar N domain-containing protein@OS=Sporomusa sphaeroides DSM 2875@GN=SPSPH 40240 tr|I9L8I1|I9L8I1 9FIRM@Lar N domain-containing protein@OS=Pelosinus fermentans B4@GN=FB4 0704 tr|A0A147JY01|A0A147JY01 9EURY@Lar N domain-containing protein@OS=Hadesarchaea archaeon DG-33-1@GN=AVW06 04425 tr|R6I717|R6I717 N domain-containing 9FIRM@Lar protein@OS=Phascolarctobacterium sp. CAG tr|A0A151EKV0|A0A151EKV0tr|A0A151ELC9|A0A151ELC9 9EURY@General glycosylationtr|A0A0K1P913|A0A0K1P913 pathway protein@OS=Thermoplasmatales 9DELT@Transcriptional regulator@OS=Vulgatibacter archaeonarchaeon SG8-52-1@GN=AYK20SG8-52-1@GN=AYK20tr|A0A140L7N2|A0A140L7N2 incomptus@GN=AKJ08 9THEO@Lar 0528005715 N domain-containing 0384 protein@OS=Fervidicolatr|R7AIT7|R7AIT7 ferrireducens@GN=AN618 9BACE@Lar N domain-containing protein@OS=Bacteroides 15880 pectinophilus CAG tr|A0A0S7XBR9|A0A0S7XBR9tr|A0A143BB72|A0A143BB72tr|A0A0B5FVA6|A0A0B5FVA6 9BACT@Lar N 9DELT@Lar domain-containing 9DELT@Lar N domain-containing N domain-containing protein@OS=Latescibacteria protein@OS=Desulfuromonas protein@OS=Geoalkalibacter bacterium DG sp. subterraneus@GN=GSUB 63@GN=AMJ46DDH964@GN=DBW 09105 3378 14505 tr|G8QZ19|G8QZ19tr|C0QKR9|C0QKR9 SPHPG@Lar DESAH@Lar N domain-containing N domain-containing protein@OS=Sphaerochaetatr|A0A062XL11|A0A062XL11 protein@OS=Desulfobacterium 9BACT@Lar pleomorpha N autotrophicum domain-containingstrain ATCC strainBAA-1885 protein@OS=Thermoanaerobaculum ATCC / DSM43914 22778 / DSM / Grapes@GN=SpiGrapes3382 / HRM2@GN=HRM2 aquaticum@GN=EG19 3132 30760 07050 tr|X0PAG6|X0PAG6 9LACO@Transcriptional regulator@OS=Lactobacillus farraginis DSMtr|A0A095XPE2|A0A095XPE2 18382 = JCM 14108@GN=FD41 9FIRM@Transcriptionaltr|C0GH88|C0GH88 9FIRM@Lar GL000557 regulator@OS=Tissierellia N domain-containing protein@OS=Dethiobacter bacterium S5-A11@GN=HMPREF1633 alkaliphilus AHT 1@GN=DealDRAFT 03380 1847 tr|A0A0Q4BHQ6|A0A0Q4BHQ6tr|A0A151E8Z4|A0A151E8Z4 9EURY@General 9EURY@General glycosylation glycosylation pathway pathwayprotein@OS=Methanomassiliicoccales protein@OS=Thermoplasmatales archaeon archaeon RumEn SM1-50@GN=AYK25tr|C0GC02|C0GC02 M1@GN=AOA80 9FIRM@Lar 05925 05390N domain-containing protein@OS=Dethiobacter alkaliphilus AHT 1@GN=DealDRAFT 0011 tr|A0A1Q9NLP8|A0A1Q9NLP8 9ARCH@Lar N domain-containing protein@OS=Candidatus Heimdallarchaeota archaeontr|A0A1X0Y106|A0A1X0Y106 tr|A5GC39|A5GC39LC 3@GN=HeimC3 9DELT@Lar GEOUR@Lar 27170 N N domain-containing domain-containing protein@OS=Geobacterprotein@OS=Geothermobacter uraniireducens sp. EPR-M@GN=B5V00 strain Rf4@GN=Gura 11750 0647 tr|A0A1Y3GD81|A0A1Y3GD81 9EURY@Nickel-dependenttr|N6WK58|N6WK58 lactatetr|A0A1Z5IGB4|A0A1Z5IGB4 9EURY@Lar racemase@OS=Methanonatronarchaeum N domain-containing 9LACO@Lactate protein@OS=Thermoplasmatales racemization thermophilum@GN=AMET1 operon protein LarA@OS=Lactobacillus archaeon SCGC 0067 AB-539-C06@GN=MBGDC06 silagei JCM 19001@GN=larA 00695 tr|R7A575|R7A575 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. CAG tr|A0A135VDA9|A0A135VDA9tr|E1RCP2|E1RCP2 9ARCH@Lar SEDSS@Lar N domain-containingtr|M7T453|M7T453 N domain-containing protein@OS=Candidatus9EURY@Lar protein@OS=Sediminispirochaeta Ntr|Q2IN59|Q2IN59 domain-containing Thorarchaeota ANADE@Lar protein@OS=Thermoplasmatales N domain-containingarchaeon smaragdinae SMTZ1-83@GN=AM324 protein@OS=Anaeromyxobacterstrain archaeon DSM 11293 SCGC / JCM AB-539-N05@GN=MBGDN0501045 15392 dehalogenans / SEBR 4228@GN=Spirsstrain 2CP-C@GN=Adeh 00234 0988 0469 tr|R5EAC4|R5EAC4 9BURK@Lar N domain-containing protein@OS=Parasutterella excrementihominis CAG tr|F4GJ35|F4GJ35 SPHCD@Lar N domain-containingtr|G9ZL73|G9ZL73 protein@OS=Sphaerochaeta 9LACO@Lar N domain-containing coccoides protein@OS=Lactobacillus strain ATCCtr|A0A0B5BJ32|A0A0B5BJ32 BAA-1237 parafarraginis / DSM F0439@GN=HMPREF9103 173749DELT@Lar / SPN1@GN=Spico N domain-containing 00471 protein@OS=Geobacter 0088 pickeringii@GN=GPICK 14895 tr|A7H7M7|A7H7M7 ANADF@Lar N domain-containing protein@OS=Anaeromyxobacter sp. strain Fw109-5@GN=Anae109 0509 tr|A0A1W2EAJ0|A0A1W2EAJ0 9DELT@Nickel-dependent lactate racemase@OS=Desulfobacterium vacuolatum DSM 3385@GN=SAMN02746065 12730 tr|F5YMB1|F5YMB1tr|A0A1W1YM25|A0A1W1YM25 TREPZ@Generaltr|A0A1I4TTN5|A0A1I4TTN5 glycosylation 9DELT@Nickel-dependent 9EURY@Nickel-dependentpathway protein@OS=Treponema lactate racemase@OS=Desulfobacterium lactate racemase@OS=Methanolobus primitia strain ATCC vacuolatumBAA-887 profundi@GN=SAMN04488696tr|A1HRB0|A1HRB0tr|A0A154BLZ4|A0A154BLZ4 / DSM DSM 12427 3385@GN=SAMN02746065 9FIRM@Lar / ZAS-2@GN=TREPR ANASB@Transcriptional N domain-containing 2455 protein@OS=Thermosinus regulator@OS=Anaerosporomusa 1011800391 carboxydivorans subterranea@GN=AXX12 Nor1@GN=TcarDRAFT 15555 1443 tr|W9DSG3|W9DSG3tr|A0A087M843|A0A087M843 METTI@Lar N domain-containing 9PROT@General protein@OS=Methanolobus glycosylation pathwaytr|E8WQY0|E8WQY0tr|A0A0A8WYA1|A0A0A8WYA1 protein@OS=Sulfurospirillum tindarius DSM GEOS8@Lar 2278@GN=MettiDRAFT 9DELT@Lar N domain-containing sp. SCADC@GN=JU57 N domain-containing protein@OS=Geobacter 2003 protein@OS=Geobacter 13340 sp. strain M18@GN=GM18 sp. OR-1@GN=OR1 3791 04059 tr|A0A1F8P0U1|A0A1F8P0U1tr|A0A0X8UZI2|A0A0X8UZI2tr|C8PGZ6|C8PGZ6tr|C6REF3|C6REF3 9CHLR@General 9EURY@Lar 9PROT@Lar9PROT@Lar glycosylationN domain-containing NN domain-containingdomain-containing pathway protein@OS=methanogenic protein protein@OS=Campylobacterprotein@OS=Campylobacter Fragment@OS=Chloroflexi archaeon gracilisshowae bacterium ISO4-H5@GN=AR505 RM3268@GN=CAMGR0001 RM3277@GN=CAMSH0001 RBG 16 48 8@GN=A2Z14 0167 21842045 13920

tr|A7H035|A7H035 CAMC5@Lar N domain-containing protein@OS=Campylobacter curvus strain 525.92@GN=CCV52592 1720 tr|R5BIY2|R5BIY2 9FIRM@Lar N domain-containing protein@OS=Veillonella sp. CAG tr|M4YMP3|M4YMP3 THEXX@Lar N domain-containing protein@OS=Thermoplasmatales archaeon strain BRNA1@GN=TALCtr|R7IHT4|R7IHT4 9BURK@Lartr|R5XNK5|R5XNK5 N01392 domain-containing 9CLOT@Lar protein@OS=Sutterella N domain-containing protein@OS=Clostridium sp. CAG bartlettii CAG tr|A0A1Q9P5J1|A0A1Q9P5J1 9ARCH@Lartr|R9T8I9|R9T8I9 N domain-containing METII@Lartr|A0A1Y0HNE7|A0A1Y0HNE7 N domain-containing protein@OS=Candidatus protein@OS=Methanomassiliicoccus 9PROT@Lar Thorarchaeota N domain-containing archaeon protein@OS=Sulfurospirillum intestinalis AB 25@GN=ThorAB25 strain Issoire-Mx1@GN=MMINT sp. SL2-1@GN=Sdiek115830 02460 1724 tr|A0A257LTN4|A0A257LTN4tr|A0A150IRQ0|A0A150IRQ0 tr|A0A1W1HKM0|A0A1W1HKM09BACT@Lartr|A0A139CI88|A0A139CI88 N domain-containing9EURY@Lar N 9DELT@Lardomain-containing protein@OS=candidate 9EURY@Lar N domain-containing protein@OS=CandidatusN domain-containing division protein@OS=Desulfamplus bacterium protein@OS=Methanolobus Methanofastidiosum WOR-3 4484 magnetovallimortis@GN=MTBBW1 18@GN=CGW93 sp.methylthiophilus@GN=APG10 T82-4@GN=AWU59 02885 2348 850012 00715 tr|A0A1Q9PBT9|A0A1Q9PBT9 9ARCH@Lartr|A0A150J2S1|A0A150J2S1 N domain-containingtr|M9SJE3|M9SJE3 protein 9EURY@Lar Fragment@OS=Candidatus METAX@Transcriptional N domain-containing regulator@OS=Methanomethylophilusprotein@OS=Candidatus Heimdallarchaeota archaeon Methanofastidiosum AB alvus 125@GN=HeimAB125 strain methylthiophilus@GN=AMQ22 Mx1201@GN=MMALV 15570tr|R5AAQ2|R5AAQ2 14900 01306 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. CAG tr|A0A135VPQ0|A0A135VPQ0tr|A0A1Q9NR54|A0A1Q9NR54 9ARCH@Lar 9ARCH@Lar N domain-containing N domain-containing protein@OS=Candidatus protein@OS=Candidatus Thorarchaeota Thorarchaeota archaeon archaeon SMTZ1-83@GN=AM324 AB 25@GN=ThorAB25 15650 23270 tr|A0A135VLC7|A0A135VLC7tr|A0A150J7B5|A0A150J7B5 9ARCH@Lartr|K0NE75|K0NE75 N domain-containing DESTT@Conserved9EURY@Lartr|I5B209|I5B209 protein@OS=Candidatus N domain-containing uncharacterized9DELT@Lar N domain-containingprotein@OS=Candidatus Thorarchaeota protein@OS=Desulfobacula protein@OS=Desulfobacterarchaeon Methanofastidiosum SMTZ1-45@GN=AM325 toluolica strain postgatei DSM methylthiophilus@GN=AMQ74 7467 2ac9@GN=DespoDRAFT 07360 / Tol2@GN=TOL2 C1132001592 00518 tr|A0A1V4RWC7|A0A1V4RWC7tr|A0A151EM12|A0A151EM12 9BACT@Lar N domain-containing THEAD@Lar protein@OS=candidate N domain-containing division protein@OS=Theionarchaea KSB1 bacterium 4484 archaeon 188@GN=B1H10 strain DG-70-1@GN=AYK19 00195tr|R7KMU1|R7KMU1 9BURK@Transcriptional 19420 regulator@OS=Sutterella sp. CAG tr|A0A135VN56|A0A135VN56tr|A0A0S8HIF6|A0A0S8HIF6tr|A0A1Q9N9I1|A0A1Q9N9I1 9ARCH@Lar 9BACT@Lar N domain-containing 9ARCH@Lar N domain-containing Nprotein@OS=Candidatus domain-containing protein@OS=Phycisphaerae protein@OS=Candidatus Thorarchaeota bacterium archaeon Odinarchaeota SM23 SMTZ1-45@GN=AM325 33@GN=AMJ81 archaeon LCB 04370 4@GN=OdinLCB4 06490 00740 tr|A0A1F4YQZ0|A0A1F4YQZ0 9BACT@Lartr|S0G5I2|S0G5I2 N domain-containing 9DELT@Lar N domain-containingprotein@OS=candidate protein@OS=Desulfotignum division Zixibacteria phosphitoxidans bacterium RBG DSM 16 53 13687@GN=Dpo 22@GN=A2W25 4c02990 04030 tr|A0A151F4H9|A0A151F4H9tr|A0A135VIB3|A0A135VIB3tr|A0A0Q0W3A0|A0A0Q0W3A0 THEAD@Lar 9ARCH@Lar N N domain-containing domain-containing 9BACT@Lar protein@OS=Theionarchaea protein@OS=Candidatus N domain-containing protein@OS=Candidatus Thorarchaeota archaeon strain archaeon DG-70-1@GN=AYK19 Cloacimonas SMTZ-45@GN=AM326 sp. SDB@GN=APR54 09975 03505 04950 tr|R6T4S2|R6T4S2 9FIRM@Transcriptional regulator@OS=Oscillibacter sp. CAG

tr|A0A1U9NQF2|A0A1U9NQF2tr|A0A1F3BBA3|A0A1F3BBA3 9BACT@Lar 9ARCH@Lar N domain-containing N domain-containing protein@OS=Anaerohalosphaera protein Fragment@OS=archaeon lusitana@GN=STSP2 RBG 16 50 20@GN=A3K71 03208 01525 tr|A0A0A7LA29|A0A0A7LA29 9EURY@HdrD1 protein@OS=Candidatus Methanoplasma termitum@GN=hdrD1tr|R6I5I6|R6I5I6tr|R7C274|R7C274 9FIRM@Transcriptional 9BURK@Transcriptional regulator@OS=Phascolarctobacterium regulator@OS=Sutterella sp. CAG sp. CAG tr|R7I2J5|R7I2J5 9BURK@Transcriptional regulator@OS=Sutterella sp. CAG

tr|Q3AFZ6|Q3AFZ6tr|A0A1M6MH85|A0A1M6MH85 CARHZ@Lar 9CLOT@Nickel-dependentN domain-containing protein@OS=Carboxydothermus lactate racemase@OS=Paramaledivibacter hydrogenoformans caminithermalis strain ATCC DSMBAA-161 15212@GN=SAMN02745912 / DSM 6008 / Z-2901@GN=CHY 01247 0066 tr|C7N3G6|C7N3G6 SLAHD@Uncharacterized conserved protein@OS=Slackia heliotrinireducens strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1@GN=Shel 26900 tr|R5BQ44|R5BQ44 9FIRM@Lar N domain-containing protein@OS=Veillonella sp. CAG tr|A0A1M6H4E0|A0A1M6H4E0 9CLOT@Nickel-dependent lactate racemase@OS=Geosporobacter subterraneus DSM 17957@GN=SAMN02745975 01437 tr|B1L4C9|B1L4C9 KORCO@Lar N domain-containing protein@OS=Korarchaeum cryptofilum strain OPF8@GN=Kcr 0555

tr|A0A1T4LNA0|A0A1T4LNA0tr|A0A1M5TLC2|A0A1M5TLC2 9FIRM@Nickel-dependent 9CLOT@Nickel-dependent lactate racemase@OS=Garciella lactate racemase@OS=Clostridium nitratireducens grantii DSM DSM 15102@GN=SAMN02745973 8605@GN=SAMN02745207 01042 01370 tr|A0A1T4VQ60|A0A1T4VQ60tr|A0A1T5KM66|A0A1T5KM66 9DELT@Nickel-dependent 9CLOT@Nickel-dependent lactate racemase@OS=Desulfovibrio lactate racemase@OS=Maledivibacter bizertensis DSM 18034@GN=SAMN02745702 halophilus@GN=SAMN02194393 00765 01966

tr|A0A1T4XNR5|A0A1T4XNR5 9CLOT@Nickel-dependent lactate racemase@OS=Caloramator quimbayensis@GN=SAMN05443428 11121 tr|A0A1W9P924|A0A1W9P924 9BACT@Lar N domain-containing protein@OS=CandidatusAminicenantes bacterium 4484 214@GN=B5M54 04200 tr|A0A1G9MD23|A0A1G9MD23 9FIRM@Nickel-dependent lactate racemase@OS=Halarsenatibacter silvermanii@GN=SAMN04488692 10832 tr|A0A1H3G1A2|A0A1H3G1A2tr|A0A172RXF7|A0A172RXF7tr|A0A1G4S394|A0A1G4S394tr|A0A0C7NRS6|A0A0C7NRS6 9FIRM@Nickel-dependent 9ACTN@Nickel-dependenttr|A0A161YRA5|A0A161YRA5tr|A0A161W1Z6|A0A161W1Z6 9FIRM@Nickel-dependent 9THEO@S-adenosyl-L-methionine-dependent lactate lactate racemase@OS=Ruminococcaceae 9CLOT@Lar 9CLOT@Lar racemase@OS=Denitrobacterium lactate racemase@OS=Ruminococcaceae N Ndomain-containing domain-containing methyltransferase-like@OS=Moorella protein@OS=Clostridiumbacterium protein@OS=Clostridium detoxificans@GN=SAMN02910314 YAD3003@GN=SAMN02910264 bacterium magnumYRB3002@GN=SAMN02910456 magnum DSM glycerini@GN=3225 DSM 2767@GN=CLMAG 2767@GN=CLMAG 01910 01132 0518002291 54180 tr|D9TSN9|D9TSN9 THETC@Lartr|A0A1M4Z0B8|A0A1M4Z0B8 N domain-containing protein@OS=Thermoanaerobacteriumtr|H1CZZ5|H1CZZ5 9CLOT@Nickel-dependent 9FIRM@Lar lactate N domain-containing thermosaccharolyticum racemase@OS=Lactonifactor protein@OS=Dialister strain ATCC longoviformis 7956succinatiphilus / DSM DSM 571 17459@GN=SAMN02745158 YIT / NCIB11850@GN=HMPREF9453 9385 / NCA 3814@GN=Tthe 02577 00933 2432 tr|A0A1H1LD54|A0A1H1LD54tr|A0A143X9S0|A0A143X9S0tr|A0A081C8U6|A0A081C8U6 9ACTN@Nickel-dependent 9ACTN@Lar N 9BACT@Lardomain-containing lactate N domain-containing racemase@OS=Olsenella protein@OS=Coriobacteriaceae protein@OS=Candidatus umbonata@GN=SAMN04489857 bacterium Vecturithrix CHKCI002@GN=BN3658 granuli@GN=U27 0835 00899 02289 tr|F0RW97|F0RW97 SPHGB@Lar N domain-containing protein@OS=Sphaerochaeta globosa strainATCC BAA-1886 / DSM 22777 / Buddy@GN=SpiBuddy 1629 tr|C5CHE7|C5CHE7tr|A0A1M4SXY4|A0A1M4SXY4tr|A0A1M4TYG2|A0A1M4TYG2 KOSOT@Lar N domain-containing 9CLOT@Nickel-dependent 9CLOT@Nickel-dependent protein@OS=Kosmotoga lactate lactate racemase@OS=Lactonifactor racemase@OS=Lactonifactor olearia strain ATCC BAA-1733 longoviformis longoviformis / DSM DSM 21960 DSM 17459@GN=SAMN02745158 17459@GN=SAMN02745158/ TBF 19.5.1@GN=Kole 0994 00320 00633 tr|A0A1Y1S0J8|A0A1Y1S0J8 9SPIO@Lar N domain-containing protein@OS=Marispirochaeta aestuarii@GN=B4O97 04465 tr|A0A101G3P4|A0A101G3P4 9BACT@Lar N domain-containing protein Fragment@OS=Parcubacteria bacterium 33 209@GN=XD75 0534 tr|A0A1F8PZ64|A0A1F8PZ64 9CHLR@Lar N domain-containingtr|A0A1D8GNY1|A0A1D8GNY1tr|A0A101WLK6|A0A101WLK6 protein@OS=Chloroflexi 9FIRM@Transcriptional9CLOT@Transcriptional bacterium regulator@OS=Clostridia regulator@OS=Geosporobacter RBG 16 54 18@GN=A2Z16 bacterium ferrireducens@GN=Gferi09070 BRH c25@GN=APF77 25290 22295 tr|A0A0Q0VHY7|A0A0Q0VHY7 9BACT@Lar N domain-containing protein@OS=Candidatus Cloacimonas sp. SDB@GN=APR54 09995 tr|A0A1G3R4U6|A0A1G3R4U6 9SPIR@Lar N domain-containing protein Fragment@OS=Spirochaetes bacterium RBG 16 67 19@GN=A2V99 03730 tr|A0A1I5NLN9|A0A1I5NLN9 9FIRM@Nickel-dependenttr|A0A0F2JDE1|A0A0F2JDE1 lactate 9FIRM@Transcriptional racemase@OS=Oscillibacter regulator@OS=Desulfosporosinus sp. PC13@GN=SAMN05216343 sp. I2@GN=UF75 104170 3430 tr|A0A0Q6VKN3|A0A0Q6VKN3 9RHIZ@Lar N domain-containing protein@OS=Rhizobium sp. Root1220@GN=ASC90 27415 tr|A0A099SAN3|A0A099SAN3 9CLOT@Transcriptional regulator@OS=Clostridium sp. HMP27@GN=DP68 02655 tr|A0A1H1YNU4|A0A1H1YNU4 9ACTN@Nickel-dependent lactate racemase@OS=Microlunatus soli@GN=SAMN04489812 4685 tr|A0A0D2J9U7|A0A0D2J9U7 9DELT@Lar N domain-containing protein@OS=Dethiosulfatarculus sandiegensis@GN=X474 07205 tr|A0A1Q8QZE5|A0A1Q8QZE5 9FIRM@Transcriptional regulator@OS=Desulfosporosinus sp. OL@GN=DSOL 1474 tr|A0A1G0ZRI9|A0A1G0ZRI9 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium RIFOXYC12 FULL 60 16@GN=A2498 16910 tr|A0A1F8QQE3|A0A1F8QQE3 9CHLR@Lar N domain-containing protein@OS=Chloroflexi bacterium RBG 16 57 11@GN=A2W35 08440 tr|I0IC56|I0IC56 PHYMF@Lar N domain-containing protein@OS=Phycisphaera mikurensis strain NBRC 102666 / KCTC 22515 / FYK2301M01@GN=PSMK 06850 tr|F4BTX1|F4BTX1 METSG@Lar N domain-containing protein@OS=Methanothrixtr|I3VRX3|I3VRX3 soehngenii THESW@Lar strain N domain-containing ATCCtr|A0A0S7BXP4|A0A0S7BXP4 5969 / DSM protein@OS=Thermoanaerobacterium 3671 / JCM 10134 9CHLR@Nickel-dependent / NBRC 103675 /saccharolyticum OCM lactate 69 / racemase@OS=FlexilineaGP-6@GN=MCON strain DSM 8691 0092 / JW/SL-YS485@GN=Tsac flocculi@GN=ATC1 131389 0232 tr|Q8PUN0|Q8PUN0tr|Q8TR71|Q8TR71 METMA@Conservedtr|M5E006|M5E006 METAC@Lar N domain-containing9FIRM@Lar protein@OS=Methanosarcinatr|C0D203|C0D203 N domain-containing protein@OS=Methanosarcina 9FIRM@Lar mazei protein@OS=Halanaerobium straintr|A0A0M2NIZ2|A0A0M2NIZ2N domain-containing ATCC acetivorans BAA-159 protein strain/ DSMsaccharolyticum 9FIRM@Transcriptional Fragment@OS=ATCC 3647 /35395 Goe1 subsp. // DSM Go1asparagiforme saccharolyticum / 2834 regulator@OS=CatabacterJCM /11833 JCM DSM 12185 / OCM 15981@GN=CLOSTASPARDSM / C2A@GN=MA 88@GN=MM 6643@GN=HSACCH hongkongensis@GN=CHK 2302 1312 0100503292 0403 tr|Q8PUM9|Q8PUM9 METMA@Transcriptional regulator@OS=Methanosarcinatr|D3QZL7|D3QZL7tr|F7V0G7|F7V0G7tr|A0A1Y4G0I6|A0A1Y4G0I6 MAGIU@Lar mazei strain N domain-containingEEGSY@LarATCC BAA-159 9ACTN@Transcriptional N domain-containing / protein@OS=MageeibacillusDSM 3647 / Goe1 protein@OS=Eggerthellaregulator@OS=Gordonibacter / Go1 / JCM indolicus 11833 strain sp./ OCM strain UPII9-5@GN=HMPREF0868sp. 88@GN=MMAn230@GN=B5F40 YY7918@GN=EGYY 2303 12910 10820 0017 tr|A0A0S8K2M1|A0A0S8K2M1tr|A0A1Y4S5R4|A0A1Y4S5R4 9CHLR@Lar N domain-containing 9FIRM@Transcriptional protein@OS=Anaerolineae regulator@OS=Flavonifractor bacterium SM23 sp. An135@GN=B5E80 84@GN=AMJ93 16820 05250 tr|D7E9V6|D7E9V6 METEZ@Lar N domain-containing protein@OS=Methanohalobiumtr|A0A1F2PJ37|A0A1F2PJ37 evestigatum strain 9FIRM@Lar ATCC BAA-1072 N domain-containing / DSM 3721 protein@OS=Acetobacterium / NBRC 107634 / OCM 161 wieringae@GN=ACWI / Z-7303@GN=Metev 15200 1526 tr|A0A1H9J6W4|A0A1H9J6W4 9ACTN@Nickel-dependent lactate racemase@OS=Friedmanniella flava@GN=SAMN05421756 106107

tr|A0A1F8Q7J7|A0A1F8Q7J7tr|A0A0J1DPA5|A0A0J1DPA5 9CHLR@Lar 9FIRM@Lar N N domain-containing domain-containing protein@OS=Chloroflexi protein@OS=Peptococcaceae bacterium bacterium RBG 16 1109@GN=AA931 54 11@GN=A2136 04555 10090 tr|G4Q3M7|G4Q3M7ACIIR@Lar N domain-containing protein@OS=Acidaminococcus intestini strain RyC-MR95@GN=Acin 0508 tr|A0A239M0A9|A0A239M0A9 9BACT@Nickel-dependent lactate racemase@OS=Granulicella rosea@GN=SAMN05421770 10911 tr|S3K323|S3K323 TREMA@Lar N domain-containing protein@OS=Treponema maltophilum ATCC 51939@GN=HMPREF9194 01682 tr|A0A2A2W4V4|A0A2A2W4V4 9BACT@Lar N domain-containing protein@OS=Rhodopirellula sp. SM50@GN=CKO51 27810 tr|A0A285BE96|A0A285BE96 9FIRM@Nickel-dependent lactate racemase@OS=Thermoanaerobacterium sp. RBIITD@GN=SAMN05660242 0972 tr|A0A1M6JZL2|A0A1M6JZL2tr|A0A1H1X356|A0A1H1X356 MALRU@Nickel-dependent lactate 9ACTN@Nickel-dependent racemase@OS=Malonomonas rubra lactateDSM 5091@GN=SAMN02745165 racemase@OS=Friedmanniella 02584 luteola@GN=SAMN04488543 2883 tr|Q8TR70|Q8TR70 METAC@Lar N domain-containing protein@OS=Methanosarcina acetivorans strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A@GN=MA 1313 tr|A0A1T5MF57|A0A1T5MF57 9CLOT@Nickel-dependent lactate racemase@OS=Maledivibacter halophilus@GN=SAMN02194393 04571 tr|A0A0D2J3H7|A0A0D2J3H7tr|A0A0Q6FEN5|A0A0Q6FEN5 9DELT@Lar N9RHIZ@Lar domain-containing N domain-containing protein@OS=Dethiosulfatarculus protein@OS=Rhizobium sandiegensis@GN=X474 sp. Leaf453@GN=ASG68 17045 16325 tr|Q464W0|Q464W0 METBF@Lar N domain-containing protein@OS=Methanosarcina barkeri strain Fusaro / DSM 804@GN=Mbar A3719 tr|W4MBD9|W4MBD9 9BACT@Lar N domain-containing protein@OS=Candidatus Entotheonella gemina@GN=ETSY2 09870 tr|R7CRF9|R7CRF9 9FIRM@Lar N domain-containing protein@OS=Dialister sp. CAG tr|A0A084UEP4|A0A084UEP4tr|W9H4L5|W9H4L5tr|D7A9Y7|D7A9Y7 STAND@Lar9PROT@Lar 9RHIZ@Lar NN domain-containing N domain-containing protein@OS=Skermanellaprotein@OS=Starkeya protein@OS=Nitratireductor novella stibiiresistens basaltis@GN=EL18 strain ATCC SB22@GN=N825 8093 02478 / DSM 506 31390 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113@GN=Snov 3500 tr|A0A0L6TY69|A0A0L6TY69 9FIRM@Transcriptional regulator@OS=Acetobacterium bakii@GN=AKG39 14365 tr|E8X5C1|E8X5C1 GRATM@Lar N domain-containing protein@OS=Granulicella tundricola strainATCC BAA-1859 / DSM 23138 / MP5ACTX9@GN=AciX9 2432 tr|A0A1Q3QYI9|A0A1Q3QYI9 9BACT@Lar N domain-containing protein@OS=Acidobacteriales bacterium 59-55@GN=BGO25 06010 tr|A0A0G2Z743|A0A0G2Z743 9BACT@Lar N domain-containing protein@OS=Kosmotoga pacifica@GN=IX53 05900 tr|A0A0M4D3G6|A0A0M4D3G6tr|A0A1G4U767|A0A1G4U767 9DELT@Nickel-dependent lactate racemase@OS=Desulfuromonas 9RHIZ@Nickel-dependent soudanensis@GN=DSOUD lactate racemase@OS=Ancylobacter 0135 rudongensis@GN=SAMN05660859 3497 tr|Q464W1|Q464W1 METBF@Lar N domain-containing protein@OS=Methanosarcina barkeri strain Fusaro / DSM 804@GN=Mbar A3718 tr|A0A1F4QAL3|A0A1F4QAL3 9BACT@Lar N domain-containing protein@OS=candidate division NC10 bacterium RBG 16 65 8@GN=A2Z31 07750 tr|A0A1H7I4H8|A0A1H7I4H8tr|A0A1B9SAN1|A0A1B9SAN1 9RHOB@Lar 9RHIZ@Lar N domain-containing N domain-containing protein@OS=Jannaschia protein@OS=Rhizobium helgolandensis@GN=SAMN04488526 sp. AC27/96@GN=A6U86 0896 24730 tr|A0A1G9ZBS8|A0A1G9ZBS8 9FIRM@Nickel-dependent lactate racemase@OS=Megasphaera paucivorans@GN=SAMN05660299 02285

tr|R6A7M7|R6A7M7 9FIRM@Lar N domain-containing protein@OS=Dialister sp. CAG tr|A0A212QPN9|A0A212QPN9 9PROT@Lar N domain-containing protein@OS=Arboricoccus pini@GN=SAMN07250955 102221 tr|R6ALW3|R6ALW3 9FIRM@Lar N domain-containing protein@OS=Dialister sp. CAG tr|R5T966|R5T966 9FIRM@Lar N domain-containing protein@OS=Dialister invisus CAG tr|W4LKF8|W4LKF8 9BACT@Lar N domain-containing protein@OS=Candidatus Entotheonella factor@GN=ETSY1 18100 tr|A0A174IC59|A0A174IC59 9CLOT@Transcriptional regulator@OS=Hungatella hathewayi@GN=ERS852407 04103 tr|A0A0J6WUR0|A0A0J6WUR0 9FIRM@Lar N domain-containing protein@OS=Megasphaera cerevisiae DSM 20462@GN=AB840 03470 tr|F7XKB0|F7XKB0tr|A0A0E3SHZ8|A0A0E3SHZ8 METZD@Lar N domain-containing 9EURY@Transcriptional protein@OS=Methanosalsum regulator@OS=Methanosarcina zhilinaetr|R7CS24|R7CS24 strain DSM 9FIRM@Lar4017 horonobensis / NBRC N domain-containing 107636 HB-1 = /JCM OCM 15518@GN=MSHOH 62 protein@OS=Dialister / WeN5@GN=Mzhil 3040sp. 0712CAG tr|A0A1F5BQH8|A0A1F5BQH8 9BACT@Lar N domain-containingtr|A0A0A0CZI4|A0A0A0CZI4 protein@OS=CandidatusAminicenantes bacterium 9PROT@Lar RBG 19FT COMBO 58 17@GN=A2V45N domain-containing 01895 protein@OS=Inquilinus limosus MP06@GN=P409 29910

tr|H1D055|H1D055 9FIRM@Lar N domain-containing protein@OS=Dialister succinatiphilusYIT 11850@GN=HMPREF9453 00993 tr|Q5HRD7|Q5HRD7 STAEQ@Conserved domain protein@OS=Staphylococcus epidermidis strain ATCC 35984 / RP62A@GN=SERP0256 tr|A0A1G1CBB9|A0A1G1CBB9 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium RIFOXYB12 FULL 65 16@GN=A3K19 11620 tr|A0B768|A0B768 METTP@Lar N domain-containingtr|A0A1W9VT42|A0A1W9VT42 protein@OS=Methanothrix 9BACT@Transcriptional thermoacetophila strain regulator@OS=Candidatus DSM 6194 / JCM 14653 /Atribacteria NBRC 101360 bacterium / PT@GN=Mthe 4572 76@GN=B6228 0752 02925 tr|A0A133S911|A0A133S911 9FIRM@Lar N domain-containing protein@OS=Megasphaera sp. MJR8396C@GN=HMPREF3201 02406

tr|R6A909|R6A909 9FIRM@Lar N domain-containing protein@OS=Dialister sp. CAG

tr|G0VL91|G0VL91 MEGEL@Lar N domain-containing protein@OS=Megasphaera elsdenii DSM 20460@GN=MELS 0248 tr|A0A240UNB2|A0A240UNB2tr|A0A1S1NTK6|A0A1S1NTK6 9GAMM@Nickel-dependent9GAMM@Lar N domain-containing lactate racemase@OS=Kushneriaprotein@OS=Kushneria marisflavi@GN=B9H00 sp. YCWA18@GN=larA 05445 tr|R6TKR6|R6TKR6 9FIRM@Lar N domain-containing protein@OS=Firmicutes bacterium CAG tr|A0A0S4MFG9|A0A0S4MFG9Streptococcus STACP@Lar N domain-containing pneumoniae protein@OS=Staphylococcus strain capitis@GN=BN1517140059 2842STDY5753546@Protein LarA@GeneID ERS409327 00523 Desguin2017 tr|A0A0E3SGM0|A0A0E3SGM0 9EURY@Transcriptional regulator@OS=Methanosarcina horonobensis HB-1 = JCM 15518@GN=MSHOH 3039 tr|A0A1M7Y2W5|A0A1M7Y2W5 9DELT@Nickel-dependent lactate racemase@OS=Desulfopila aestuarii DSM 18488@GN=SAMN02745220 01445

tr|A0A0E3SM79|A0A0E3SM79 METBA@Transcriptional regulator@OS=Methanosarcina barkeri 3@GN=MSBR3 1385 tr|A0A2D5Z3Z1|A0A2D5Z3Z1 9BACT@Lar N domain-containing protein@OS=Phycisphaeraceaetr|A0A1M5UUX6|A0A1M5UUX6 bacterium@GN=CMJ18 06480 9DELT@Nickel-dependent lactate racemase@OS=Desulfofustis glycolicus DSM 9705@GN=SAMN02745124 01329 tr|F7YUH3|F7YUH3tr|A0A1Z5HQT9|A0A1Z5HQT9 9THEM@Lar 9THEO@Lar N domain-containingtr|R5TDF1|R5TDF1 N domain-containing protein@OS=Pseudothermotoga 9FIRM@Transcriptional protein@OS=Calderihabitans regulator@OS=Dialister thermarum maritimus@GN=KKC1 DSM 5069@GN=Theth invisus CAG 10570 1382 tr|H1D0B8|H1D0B8 9FIRM@Lar N domain-containing protein@OS=Dialister succinatiphilusYIT 11850@GN=HMPREF9453 01056 tr|D5EAP5|D5EAP5 METMS@Lartr|A0A0E3WVK9|A0A0E3WVK9 N domain-containing protein@OS=Methanohalophilus METBA@Transcriptionaltr|R6LM44|R6LM44tr|R6LPX9|R6LPX9 9FIRM@Lar regulator@OS=Methanosarcina 9FIRM@Lar mahii strain N domain-containingN ATCCdomain-containing 35705 / DSMprotein@OS=Firmicutes barkeri protein@OS=Firmicutes 5219 3@GN=MSBR3 / SLP@GN=Mmah bacterium 1386 bacterium 0722 CAG CAG tr|Q4A0S0|Q4A0S0tr|A0A658RT91|A0A658RT91tr|A0A291JI36|A0A291JI36tr|A0A0Q9XYL7|A0A0Q9XYL7tr|A0A151A2H3|A0A151A2H3 STAS1@Lar 9STAP@Domain STACC@Domain 9STAP@Lar N domain-containing NNof domain-containingdomain-containing uncharacterizedof uncharacterized protein@OS=Staphylococcus function protein@OS=Staphylococcusprotein@OS=Staphylococcus function DUF2088@OS=Staphylococcus DUF2088@OS=Staphylococcus saprophyticus sp. kloosii@GN=A0131 NAM3COL9@GN=ACA31subsp. nepalensis@GN=larA saprophyticus cohnii subsp. 02160 straincohnii@GN=SAMEA3109313 12105 ATCC 15305 / DSM 20229 00030 / NCIMB 8711 / NCTC 7292 / S-41@GN=SSP0177 tr|Q464V9|Q464V9 METBF@Lar N domain-containing protein@OS=Methanosarcina barkeri strain Fusaro / DSM 804@GN=Mbar A3720 tr|A0A1G0Z7P2|A0A1G0Z7P2 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium GWF2 50 93@GN=A2X45 07585 tr|A0A1E7GBC9|A0A1E7GBC9tr|A0A1E7GBE7|A0A1E7GBE7 9EURY@Transcriptional regulator@OS=Methanosarcina sp. Ant1@GN=BGV40 1039010385 tr|R7CM60|R7CM60 9FIRM@Lar N domain-containing protein@OS=Dialister sp. CAG tr|D1YV83|D1YV83 METPS@Lar N domain-containing protein@OS=Methanocella paludicola strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE@GN=MCP 0283 tr|A0A1G0YEE1|A0A1G0YEE1 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium GWF2 49 21@GN=A2X48 05210 tr|K4LLF6|K4LLF6 THEPS@Lar N domain-containingtr|A0A0E3L624|A0A0E3L624tr|A0A0E3L524|A0A0E3L524 protein@OS=Thermacetogenium 9EURY@Transcriptional 9EURY@Transcriptionaltr|R5APA9|R5APA9 phaeum regulator@OS=Methanosarcina regulator@OS=Methanosarcina strain 9CLOT@Lar ATCC BAA-254 N domain-containing / DSMsp. sp. MTP4@GN=MSMTP 12270 WH1@GN=MSWH1 /protein@OS=Clostridium PB@GN=Tph 0807 2255 c27620 sp. CAG tr|B8IYJ9|B8IYJ9 DESDA@Lar N domain-containing protein@OS=Desulfovibrio desulfuricans strain ATCC 27774 / DSM 6949@GN=Ddes 2379 tr|A0A1Z8WXM0|A0A1Z8WXM0 9CHLR@Lar N domain-containing protein@OS=Chloroflexi bacterium TMED70@GN=CBC30 04675 tr|G7WMU5|G7WMU5tr|A0A0E3S0S8|A0A0E3S0S8tr|A0A0F8EQA6|A0A0F8EQA6 METH6@Lar N domain-containing 9EURY@Transcriptional 9EURY@Transcriptional protein@OS=Methanosaetatr|R6GR47|R6GR47 regulator@OS=Methanosarcina regulator@OS=Methanosarcina harundinacea9FIRM@Lar N straindomain-containing lacustris 6Ac@GN=Mhar sp. 2.H.A.1B.4@GN=EO92 Z-7289@GN=MSLAZ protein@OS=Oscillibacter 1142 02085 0998 sp. CAG tr|A0A1Z8WY21|A0A1Z8WY21 9CHLR@Lartr|A0A0S8JSN6|A0A0S8JSN6 N domain-containing protein Fragment@OS=Chloroflexi 9BACE@Lar bacterium N TMED70@GN=CBC30 domain-containing 04085 protein Fragment@OS=Bacteroides sp. SM23 62@GN=AMS26 16320 tr|A0A061P2N3|A0A061P2N3tr|A0A0V8J051|A0A0V8J051 9BACL@Transcriptional 9BACI@Lar N domain-containing regulator@OS=Geomicrobium protein@OS=Fictibacillus sp. JCM 19038@GN=JCM19038 enclensis@GN=AS030 2925 20225 tr|F0YVA4|F0YVA4 9CLOT@Putative transcriptional regulator@OS=Clostridium sp. D5@GN=HMPREF0240 01074 tr|A0A1C4L189|A0A1C4L189tr|A0A1F8RGY4|A0A1F8RGY4 9ACTN@Lar N domain-containing 9CHLR@Lar N protein@OS=Streptomyces domain-containing protein@OS=Chloroflexi sp. DvalAA-14@GN=GA0115240 bacterium 11921 RBG 16 64 32@GN=A2W34 03670 tr|A0A1G7P6U7|A0A1G7P6U7 9DELT@Nickel-dependent lactate racemase@OS=Desulfovibrio legallii@GN=SAMN05192586 11432 tr|A0A0Q5VKU2|A0A0Q5VKU2 9ACTN@Lar N domain-containing protein@OS=Geodermatophilus sp. Leaf369@GN=ASG36 18275 tr|Q0W3S9|Q0W3S9 METAR@Lar N domain-containing protein@OS=Methanocella arvoryzae strain DSM 22066 / NBRC 105507 / MRE50@GN=RCIX1757 tr|A0A136MT91|A0A136MT91 9BACT@Lar N domain-containing protein@OS=Omnitrophica bacterium OLB16@GN=UZ16 OP3001001285 tr|A0A062V5S0|A0A062V5S0tr|A0A117LGB3|A0A117LGB3 9EURY@Lar 9EURY@Lar N domain-containing N domain-containing protein@OS=Candidatus protein@OS=Methanosaeta Methanoperedens harundinacea@GN=XD72 nitroreducens@GN=ANME2D 0071 03191 tr|N2AEJ2|N2AEJ2 9FIRM@Lar N domain-containing protein@OS=Schaedlerella arabinosiphila@GN=C824 02757 tr|A0A0S7BTB5|A0A0S7BTB5 9CHLR@Nickel-dependent lactate racemase@OS=Flexilinea flocculi@GN=ATC1 131234 tr|C8X5B3|C8X5B3 DESRD@Lar N domain-containing protein@OS=Desulfohalobium retbaense strain ATCC 49708 / DSM 5692 / JCM 16813 / HR100@GN=Dret 2326 tr|R6IBP1|R6IBP1 9FIRM@Lar N domain-containing protein@OS=Phascolarctobacterium sp. CAG tr|A3ZLC3|A3ZLC3 9BACT@Lar N domain-containing protein@OS=Blastopirellula marina DSM 3645@GN=DSM3645 09162 tr|A0A1L3MTX6|A0A1L3MTX6tr|A0A1I1S380|A0A1I1S380 9BACI@Nickel-dependent 9BACI@Lar N domain-containing lactate racemase@OS=Bacillus protein@OS=Bacillus weihaiensis@GN=A9C19 sp. OV194@GN=SAMN05428981 14225 101144 tr|A0A1M7T3M1|A0A1M7T3M1 9DELT@Nickel-dependent lactate racemase@OS=Desulfovibrio litoralis DSM 11393@GN=SAMN02745728 01512 tr|A0A098Y7A4|A0A098Y7A4 9ACTN@Lartr|A0A1W5ZZL3|A0A1W5ZZL3tr|A0A1H4AFS5|A0A1H4AFS5 N domain-containing protein@OS=Modestobacter 9BACI@Lar9BACI@Nickel-dependent caceresii@GN=IN07 N domain-containing 16070 lactate protein@OS=Halobacillus racemase@OS=Thalassobacillus mangrovi@GN=HM131 cyri@GN=SAMN05421743 18335 10479 tr|A0A0E3NSE6|A0A0E3NSE6 9EURY@Transcriptional regulator@OS=Methanosarcina sp. WH1@GN=MSWH1 2256 tr|R6I1T4|R6I1T4 9FIRM@Lar N domain-containing protein@OS=Firmicutes bacterium CAG tr|A0A1N6RW87|A0A1N6RW87 9BACI@Nickel-dependent lactate racemase@OS=Domibacillus enclensis@GN=SAMN05443094 102233

tr|R6I4K2|R6I4K2 9FIRM@Lar N domain-containing protein@OS=Phascolarctobacterium sp. CAG tr|R1I9C1|R1I9C1 9PSEU@Lar tr|A0A0K0ILG0|A0A0K0ILG0N domain-containing protein@OS=Amycolatopsis 9FIRM@Lar vancoresmycina N DSM domain-containing 44592@GN=H480 18808 protein@OS=Bacilli bacterium VT-13-104@GN=WH51 16280 tr|A0A1H3IRD3|A0A1H3IRD3tr|I4F1C3|I4F1C3 9ACTN@Lar 9ACTN@Nickel-dependent N domain-containingtr|A0A0A3HYV0|A0A0A3HYV0tr|A0A098F1Z8|A0A098F1Z8tr|A0A0M2SVW3|A0A0M2SVW3 protein@OS=Modestobacter lactate racemase@OS=Modestobacter marinus@GN=MODMU 9BACI@Lar9BACI@Lar 9BACI@Lar sp. DSM NN44400@GN=SAMN05661080 4034 domain-containingdomain-containing N domain-containing 03011 protein@OS=Lysinibacillusprotein@OS=Bacillus protein@OS=Bacillus sp. B-jedd@GN=BN1002 manganicus campisalis@GN=WQ57 DSM 26584@GN=CD29 03593 06890 14370 tr|R5BU23|R5BU23 9FIRM@Lar N domain-containing protein@OS=Blautia hydrogenotrophica CAG tr|A0A0F0GNQ9|A0A0F0GNQ9 LENAE@Lar N domain-containing protein@OS=Lentzea aerocolonigenes@GN=UK23 34660 tr|A0A1E7GC25|A0A1E7GC25tr|A0A0E3SJX5|A0A0E3SJX5 METBA@Transcriptional9EURY@Transcriptional regulator@OS=Methanosarcinaregulator@OS=Methanosarcina sp.barkeri Ant1@GN=BGV40 3@GN=MSBR3 10380 1383 tr|A0A0F7NBZ6|A0A0F7NBZ6tr|G0FIG7|G0FIG7tr|A0A1H4SNW4|A0A1H4SNW4tr|A0A1B2HTS1|A0A1B2HTS1 AMYMS@Lartr|I4D9B9|I4D9B9 9ACTN@Lartr|A0A0A6VBE2|A0A0A6VBE2tr|A0A0K9GPK1|A0A0K9GPK1 N9PSEU@Nickel-dependent9PSEU@Lar domain-containing N domain-containing NDESAJ@Lar domain-containing protein@OS=Amycolatopsis lactateprotein@OS=Streptomyces N domain-containingracemase@OS=Amycolatopsis protein@OS=Lentzea 9BACI@Lar 9BACI@Lar mediterranei sp. CNQ-509@GN=AA958 protein@OS=Desulfosporosinus guizhouensis@GN=BBK82N strainN domain-containing domain-containing tolypomycina@GN=SAMN04489727 S699@GN=RAM 29850 15685 39260 protein@OS=Bacillus protein@OS=Bacillus acidiphilus 3829 strain DSM ginsengihumi@GN=NG54 loiseleuriae@GN=AC625 22704 / JCM 16185 / SJ4@GN=Desaci 12490 02380 3505 tr|A0A177YFW2|A0A177YFW2tr|A0A1M7NLZ0|A0A1M7NLZ0tr|A0A239MQH0|A0A239MQH0tr|A0A1Y6K9H5|A0A1Y6K9H5 9NOCA@Lar 9ACTN@Nickel-dependent 9ACTN@Nickel-dependent tr|A0A0A1MUF2|A0A0A1MUF2tr|A0A1H0CVY7|A0A1H0CVY7N domain-containing 9CHLR@Lar protein@OS=Rhodococcus lactate lactate N racemase@OS=Streptomyces domain-containing racemase@OS=Streptomyces kyotonensis@GN=A3K89 9BACI@Nickel-dependent9BACI@Lar protein@OS=Brevefilum 03155 paucisporeus@GN=SAMN05216499 glauciniger@GN=SAMN05216252 N domain-containing fermentans@GN=CFX1CAM lactate 11939 12698 racemase@OS=Psychrobacillus protein@OS=Oceanobacillus 1615 oncorhynchi@GN=BN997 sp. OK028@GN=SAMN05518871 02427 106161 tr|G1UV81|G1UV81 9DELT@Lar N domain-containing protein@OS=Desulfovibriotr|A0A0E3NXB1|A0A0E3NXB1 sp. 6 1 46AFAA@GN=HMPREF1022 9EURY@Transcriptional regulator@OS=Methanosarcina 02455 sp. MTP4@GN=MSMTP 0806 tr|A0A0S8JLP9|A0A0S8JLP9tr|A0A225DLH5|A0A225DLH5 9BACT@Lar 9BACT@Transcriptional N domain-containing proteinregulator@OS=Fimbriiglobus Fragment@OS=candidatetr|A0A229SVZ3|A0A229SVZ3tr|A0A0N0A0L3|A0A0N0A0L3 ruber@GN=FRUBdivision BRC1 bacterium 05393 SM23 51@GN=AMJ85tr|G7WCP3|G7WCP3 060659PSEU@Lartr|A0A177LAL7|A0A177LAL7 9NOCA@Lar N domain-containing N domain-containing DESOD@Lar protein@OS=Amycolatopsis protein@OS=Nocardia N 9BACI@Lardomain-containing vastitatis@GN=CF165 sp. N NRRL domain-containing protein@OS=Desulfosporosinus S-836@GN=ADL03 30950 21660 protein@OS=Domibacillus orientis strain ATCC aminovorans@GN=AWH49 19365 / DSM 765 / NCIMB 8382 09640 / VKM B-1628@GN=Desor 0905 tr|A0A1Q9SLI0|A0A1Q9SLI0tr|A0A1H0H7J3|A0A1H0H7J3tr|A0A1H3N6Z7|A0A1H3N6Z7tr|A0A0X3SEA1|A0A0X3SEA1tr|A0A0X3XWE8|A0A0X3XWE8 9PSEU@Lar 9ACTN@Nickel-dependent9ACTN@Nickel-dependent 9ACTN@Lar 9ACTN@Lar N domain-containing N Ndomain-containing domain-containinglactate protein@OS=Pseudonocardia racemase@OS=Geodermatophilus protein@OS=Streptomyces protein@OS=Streptomyces sp. CNS-139@GN=BJF78 africanus@GN=SAMN05660209sp. DSM sp. 45219@GN=SAMN05428965 sp. NRRL NRRL 26765 F-5122@GN=ADL25 WC-3605@GN=ADL34 03882 2873 15075 06450 tr|B8DQ76|B8DQ76 DESVM@Lar N domain-containing protein@OS=Desulfovibrio vulgaris strain Miyazaki F / DSM 19637@GN=DvMF 1997 tr|D2SCP8|D2SCP8 GEOOG@Lartr|H5Y1T5|H5Y1T5 N tr|A0A0M0KFN2|A0A0M0KFN2domain-containing protein@OS=Geodermatophilus 9FIRM@Lar N domain-containing obscurus 9BACI@Lar strain ATCC 25078 N /protein@OS=Desulfosporosinus domain-containingDSM 43160 / JCM 3152 / G-20@GN=Gobs protein@OS=Bacillus 1559 youngiae DSM koreensis@GN=AMD01 17734@GN=DesyoDRAFT 23235 0814 tr|E8QWZ4|E8QWZ4 ISOPI@Lar N domain-containing protein@OS=Isosphaera pallida strainATCC 43644 / DSM 9630tr|A0A1H0DGS6|A0A1H0DGS6 / IS1B@GN=Isop 3476 9BACL@Nickel-dependent lactate racemase@OS=Paenibacillus sp. yr247@GN=SAMN04487897 104106 tr|F0YWB9|F0YWB9 9CLOT@Putative transcriptional regulator@OS=Clostridium sp. D5@GN=HMPREF0240 00194 tr|A0A1V2QV73|A0A1V2QV73 9PSEU@Lar N domain-containing protein@OS=Saccharothrix sp. ALI-22-I@GN=ALI22I 06150 tr|A0A1I6RNF0|A0A1I6RNF0tr|A0A239DZW5|A0A239DZW5tr|A0A1V2QV04|A0A1V2QV04tr|A7HGF3|A7HGF3 9PSEU@Nickel-dependent 9ACTN@Nickel-dependenttr|A0A1Q8QY96|A0A1Q8QY96tr|A0A0F2JA04|A0A0F2JA04tr|A0A1M5Z2L6|A0A1M5Z2L6 9PSEU@Lar lactateANADF@Lar N lactateracemase@OS=Saccharopolyspora domain-containing racemase@OS=Geodermatophilus N domain-containing 9FIRM@Transcriptional 9FIRM@Transcriptional9FIRM@Nickel-dependent protein Fragment@OS=Saccharothrixflava@GN=SAMN05660874 pulveris@GN=SAMN06893096 protein@OS=Anaeromyxobacter regulator@OS=Desulfosporosinus regulator@OS=Desulfosporosinus 02415 lactate sp. 103450 ALI-22-I@GN=ALI22I racemase@OS=Desulfosporosinus sp. strain 05525 Fw109-5@GN=Anae109 sp. sp. I2@GN=UF75 OL@GN=DSOL lacus 5378 3618 DSM1919 15449@GN=SAMN02746098 02908 tr|A0A0U2VM86|A0A0U2VM86tr|H6NTK3|H6NTK3 9BACL@Lar 9BACL@DUF2088 N domain-containing domain-containing protein@OS=Paenibacillus protein@OS=Paenibacillus mucilaginosus naphthalenovorans@GN=IJ22 3016@GN=PM3016 169 40950 tr|G9PTZ5|G9PTZ5 9BACT@Lar N domain-containing protein@OS=Synergistes sp. 3 1 syn1@GN=HMPREF1006 02038 tr|W0ED41|W0ED41tr|A0A1I4DN35|A0A1I4DN35 9FIRM@Lar 9BACL@Nickel-dependent N domain-containing protein@OS=Desulfitobacterium lactate racemase@OS=Paenibacillus metallireducens sp. DSM 1 12@GN=SAMN03159341 15288@GN=DESME 07920 102331 tr|C7LPK7|C7LPK7 DESBD@Lar N domain-containing protein@OS=Desulfomicrobium baculatum strain DSM 4028 / VKM B-1378@GN=Dbac 2152 tr|G2FPY5|G2FPY5tr|A0A1R1CFN0|A0A1R1CFN0tr|A0A1I7L5B4|A0A1I7L5B4 9FIRM@Lar 9BACL@Nickel-dependent N 9BACL@Lar domain-containing N domain-containing protein@OS=Desulfosporosinus lactate racemase@OS=Alicyclobacillus protein@OS=Paenibacillus sp. OT@GN=DOT sp. macrosporangiidus@GN=SAMN05421543 FSL 1759 H7-0331@GN=BK127 02080 12535 tr|A0A1H1VYN0|A0A1H1VYN0tr|A0A0Q6FBP0|A0A0Q6FBP0tr|C7Q341|C7Q341 CATAD@Lar 9ACTN@Nickel-dependent9ACTN@Lartr|A0A0K9YWY4|A0A0K9YWY4 N domain-containing N domain-containing lactate protein@OS=Catenulispora racemase@OS=Marmoricolaprotein@OS=Marmoricola 9BACL@Larsp. scoriae@GN=SAMN04488570 Leaf446@GN=ASG49acidiphila strain DSMN 08330domain-containing 44928 2973 / NRRL B-24433 / NBRC protein@OS=Brevibacillus 102108 / JCM 14897@GN=Caci 4917 reuszeri@GN=ADS79 04465 tr|A0A1H4S3X2|A0A1H4S3X2 9BACL@Nickel-dependent lactate racemase@OS=Paenibacillus sp. GP183@GN=SAMN05443246 3935 tr|A0A073ITP9|A0A073ITP9 9BACT@Lar N domain-containing protein@OS=Synergistes jonesii@GN=EH55 12590 tr|A0A286RAK4|A0A286RAK4 9BACT@Transcriptional regulator@OS=Thermoguttatr|A0A1F8RUM4|A0A1F8RUM4 terrifontis@GN=THTE tr|A0A1A5XRW5|A0A1A5XRW50387 9CHLR@Lar N domain-containing 9BACL@Lar protein@OS=Chloroflexi N domain-containing bacterium RBGprotein@OS=Brevibacillus 16 68 14@GN=A2148 10545 sp. WF146@GN=A6764 04870 tr|F4CU05|F4CU05tr|A0A292YT79|A0A292YT79tr|A0A1V1W3H9|A0A1V1W3H9tr|A0A101RSL3|A0A101RSL3 PSEUX@Lar 9PSEU@Transcriptionaltr|A0A1U7MGS6|A0A1U7MGS6 N9ACTN@Lar domain-containing 9ACTN@Lar N domain-containing protein@OS=Pseudonocardiaregulator@OS=Pseudonocardia N domain-containing protein@OS=Nocardioides dioxanivorans 9FIRM@Lar protein@OS=Streptomycessp. N23@GN=TOK sp. strain PD653@GN=PD653 ATCC N1606 55486domain-containing / DSM 2225 griseorubiginosus@GN=AQJ54 44775 / JCM 13855 protein@OS=Sporomusa / CB1190@GN=Psed 35040 1167 sphaeroides DSM 2875@GN=SPSPH 01150 tr|D6SKH1|D6SKH1 9DELT@Lartr|A0A0C2RAW1|A0A0C2RAW1 N domain-containingtr|A0A101VY26|A0A101VY26 protein@OS=Desulfonatronospira 9BACL@Lar N9FIRM@Lar domain-containing N domain-containing thiodismutans protein@OS=Paenibacillus ASO3-1@GN=Dthioprotein@OS=Gracilibacter sp. VKM PD3845 B-2647@GN=SD70 sp. BRH c7a@GN=APF84 23815 10900 tr|F4A1I2|F4A1I2 MAHA5@Lar N domain-containing protein@OS=Mahellatr|A0A177RA74|A0A177RA74 australiensis straintr|A0A0U2UGY6|A0A0U2UGY6tr|M8DCL6|M8DCL6 DSM 15567 / CIP 107919 / 50-1 9BACT@Lar BON@GN=Mahau 08189BACL@Lar N domain-containing 9BACL@Lar N domain-containing protein@OS=Verrucomicrobiaceae N domain-containing protein@OS=Brevibacillus bacteriumprotein@OS=Paenibacillus SCGC AG-212-N21@GN=AYO49 borstelensis naphthalenovorans@GN=IJ22AK1@GN=I532 00820 18197 20540 tr|A0A263DU16|A0A263DU16tr|A0A1V4EBB2|A0A1V4EBB2tr|A0A1N7HJ81|A0A1N7HJ81tr|A0A0S7BHX0|A0A0S7BHX0tr|A0A259UIQ7|A0A259UIQ7 9PSEU@Lartr|A0A0P9CTA3|A0A0P9CTA3 9ACTN@Nickel-dependent9ACTN@Lar N domain-containing N domain-containing 9CHLR@Uncharacterized lactate protein@OS=Pseudonocardia protein@OS=Microbisporaracemase@OS=Microbispora 9FIRM@Lar 9BACL@Lar N sp.domain-containing MH-G8@GN=CFP66 conservedsp. rosea@GN=SAMN05421833GKUN domain-containing 823@GN=B1L11 protein@OS=Longilinea 15435 protein@OS=Sporomusa 24420 15614 protein@OS=Alicyclobacillus arvoryzae@GN=LARV silvacetica DSM 02450 ferrooxydans@GN=AN477 10669@GN=SPSIL 31000 15180 tr|A0A081NUF3|A0A081NUF3 9BACL@Lar N domain-containing protein@OS=Paenibacillus tyrfis@GN=ET33 28285 tr|A0A1E4PIN2|A0A1E4PIN2 9PSEU@Lar N domain-containing protein@OS=Pseudonocardia sp. SCN 73-27@GN=ABT15 05645 tr|A0A1W9RID4|A0A1W9RID4 9BACT@Lartr|A0A285EM78|A0A285EM78 N domain-containing protein@OS=candidate 9ACTN@Nickel-dependent division KSB1 bacterium 4484 87@GN=B6D60 lactate racemase@OS=Geodermatophilus 09515 sabuli@GN=SAMN06893097 11451 tr|A0A1F2P884|A0A1F2P884 9EURY@Transcriptional regulator@OS=Candidatus Syntrophoarchaeum caldarius@GN=SCAL 001653 tr|A0A1I4HNT5|A0A1I4HNT5tr|A0A2A4M8X4|A0A2A4M8X4 9ACTN@Nickel-dependent lactate racemase@OS=Geodermatophilus 9BACT@Lar N domain-containing ruber@GN=SAMN04488085 protein@OS=Verrucomicrobiales 11159 bacterium@GN=COC21 00985 tr|A0A1F2P529|A0A1F2P529 9EURY@Transcriptional regulator@OS=Candidatus Syntrophoarchaeum butanivorans@GN=SBU 000931 tr|A0A0M2U045|A0A0M2U045 9FIRM@Lar N domain-containing protein@OS=Clostridiales bacterium PH28 bin88@GN=SY88 20380 tr|A0A0F8VFG2|A0A0F8VFG2 LOKSG@Lar N domain-containing protein@OS=Lokiarchaeum sp. strain GC14 75@GN=Lokiarch 29640 tr|A0A1F5B7L4|A0A1F5B7L4tr|A0A1W2BDN6|A0A1W2BDN6 9BACT@Lar 9FIRM@Nickel-dependent N domain-containing protein@OS=Candidatus lactate racemase@OS=Sporomusa Aminicenantes bacterium malonica@GN=SAMN04488500 RBG 19FT COMBO 65 30@GN=A2V57 107111 04595 tr|I4C8M9|I4C8M9 DESTA@Lar tr|A0A229UNQ0|A0A229UNQ0N domain-containing protein@OS=Desulfomonile 9BACL@Lar N domain-containing tiedjei strain ATCC protein@OS=Paenibacillus 49306 / DSM 6799 / DCB-1@GN=Desti rigui@GN=CF651 3261 17720 tr|A0A1G9YVP1|A0A1G9YVP1tr|B9XF84|B9XF84tr|A0A1F5A8F9|A0A1F5A8F9 9ACTN@Nickel-dependent PEDPL@Lar lactate racemase@OS=Geodermatophilus N 9BACT@Lar domain-containing N domain-containing siccatus@GN=SAMN05660642protein@OS=Pedosphaera protein@OS=Candidatus 04143 parvula strain Ellin514@GN=Cflav Aminicenantes bacterium PD4261 RBG 16 66 30@GN=A2W20 05005 tr|A0A0F8VFN3|A0A0F8VFN3 LOKSG@Lar N domain-containing protein@OS=Lokiarchaeum sp. strain GC14 75@GN=Lokiarch 28170 tr|B4DB88|B4DB88tr|A0A0A5GKQ9|A0A0A5GKQ9 9BACT@Lar N domain-containing 9BACI@Lar protein@OS=Chthoniobacter N domain-containing flavus protein@OS=Pontibacillus Ellin428@GN=CfE428DRAFT marinus 6179 BH030004 = DSM 16465@GN=N783 00425 tr|A0A1J5ASQ4|A0A1J5ASQ4tr|A0A075K742|A0A075K742tr|I8RID3|I8RID3 9FIRM@Lar 9CHLR@Lar 9FIRM@Lar N domain-containing N domain-containing N domain-containing protein@OS=Pelosinus protein@OS=Anaerolineae protein@OS=Pelosinus fermentans bacterium sp.B4@GN=FB4 UFO1@GN=UFO1 CG2 30 642806 16@GN=AUK03 0449 01900 tr|A0A1W1W3A7|A0A1W1W3A7 9THEO@Nickel-dependent lactate racemase@OS=Thermanaeromonas toyohensis ToBE@GN=SAMN00808754 3184 tr|A1HS76|A1HS76 9FIRM@Lar N domain-containing protein@OS=Thermosinus carboxydivorans Nor1@GN=TcarDRAFT 0648 tr|L0FC70|L0FC70tr|Q2RH63|Q2RH63 tr|V4J0R0|V4J0R0DESDL@Lar MOOTA@Lar N domain-containing 9DELT@Lar N domain-containing N domain-containing protein@OS=Desulfitobacterium protein@OS=Moorella protein@OS=uncultured dichloroeliminans thermoacetica Desulfofustis strain sp. LMGATCC PB-SRB1@GN=N839 P-21439 39073 / /JCM DCA1@GN=Desdi 9320@GN=Moth 13935 3122 1926 tr|A0A1G9L7J6|A0A1G9L7J6tr|A0A1X1Q4Y6|A0A1X1Q4Y6tr|A0A0B2JXY5|A0A0B2JXY5 9CLOT@Nickel-dependent 9FIRM@Lactate9FIRM@Putative racemization D-mannonate lactate operon dehydrogenase@OS=Anaerovibrioracemase@OS=Sarcina protein LarA@OS=Anaerovibrio sp. DSM 11001@GN=SAMN04487833 sp. lipolyticus@GN=NZ47 JC8@GN=D081 1654 10040 12321 tr|A0A1G1A6G6|A0A1G1A6G6 9BACT@Lar N domain-containing protein Fragment@OS=Lentisphaerae bacterium RIFOXYA12 FULL 48 11@GN=A2283 08980 tr|E8N4X7|E8N4X7 ANATU@Lar N domain-containing protein@OS=Anaerolineatr|D5X7P3|D5X7P3 THEPJ@Lar thermophila N straindomain-containing DSM 14523 / protein@OS=ThermincolaJCM 11388 / NBRC 100420 potens / UNI-1@GN=ANT strain JR@GN=TherJR 14630 1764 tr|A0A1F8SUZ5|A0A1F8SUZ5tr|A0A1Q3SEJ4|A0A1Q3SEJ4 9CHLR@Lar 9CHLR@Lar N domain-containing N domain-containing protein@OS=Chloroflexi protein@OS=Chloroflexi bacterium bacterium RBG 19FTtr|D4J9Z1|D4J9Z1 54-19@GN=BGO39 COMBO 55 16@GN=A2Z45 13270 06755 9FIRM@Uncharacterized conserved protein@OS=Coprococcus catus GD/7@GN=CC1 25140 tr|A0A1Y6K4L1|A0A1Y6K4L1 9CHLR@Lar N domain-containing protein@OS=Brevefilum fermentans@GN=CFX1CAM 1597 tr|A0A1W9U9S4|A0A1W9U9S4 9CHLR@Uncharacterized protein@OS=Anaerolineaceae bacterium 4572tr|F7V829|F7V829 32.2@GN=B6I35 13555 CLOSS@Lar N domain-containing protein@OS=Clostridium sp. strain SY8519@GN=CXIVA 03220 tr|A0A0N8GM95|A0A0N8GM95 9CHLR@Lar N domain-containing protein@OS=Leptolinea tardivitalis@GN=ADM99 00825 tr|A0A133V4P4|A0A133V4P4tr|A0A256XRK6|A0A256XRK6tr|A0A151BC46|A0A151BC46 9EURY@Lar BATXB@Lactate9CREN@Lar N domain-containing N domain-containing racemization protein@OS=candidate operon protein@OS=Thermofilum protein LarA@OS=Bathyarchaeota division MSBL1 sp. ex4484 archaeon archaeon79@GN=B6U94 SCGC-AAA259O05@GN=AKJ41 strain B24@GN=AYL29 06265 007010 01575 tr|A0A0J1FAY7|A0A0J1FAY7tr|Q24SF3|Q24SF3tr|A0A101VD21|A0A101VD21 DESHY@Lar 9FIRM@Lar 9FIRM@Lar N domain-containing N domain-containing N domain-containing protein@OS=Desulfitobacterium protein@OS=Peptococcaceae protein@OS=Desulfitibacter hafniense bacterium sp. strainBRH CEB3@GN=CEB3 c19@GN=APF76Y51@GN=DSY3250 c29370 05610 tr|N2A7W3|N2A7W3tr|E3GG45|E3GG45tr|J1H8B4|J1H8B4tr|A0A1C0BQB5|A0A1C0BQB5 9FIRM@Lar 9CLOT@PF098619FIRM@Nickel-dependent N domain-containing 9CLOT@Lactate family protein@OS=Clostridium lactate protein@OS=Eubacterium racemization racemase@OS=Eubacterium operon sp. protein MSTE9@GN=HMPREF1141plexicaudatum LarA@OS=Clostridium callanderi@GN=ELI ASF492@GN=C823 sp. 36291397 W14A@GN=A7X67 03268 12650 tr|F3ZZ60|F3ZZ60tr|A0A1J5A2Q1|A0A1J5A2Q1tr|A0A0P6YHZ5|A0A0P6YHZ5 MAHA5@Lar N domain-containing 9CHLR@Lar 9CHLR@Lar N protein@OS=Mahelladomain-containing N domain-containing protein@OS=Anaerolineae protein@OS=Thermanaerothrixaustraliensis strain DSM bacterium15567 /daxensis@GN=SE15 CIP CG2 107919 30 64 / 50-116@GN=AUK03 BON@GN=Mahau 06190 15350 2706 tr|A0A133UAA3|A0A133UAA3tr|A0A133V4N6|A0A133V4N6 9EURY@Lar 9EURY@Lartr|S0J4F8|S0J4F8tr|R9KKS9|R9KKS9tr|R9IWY7|R9IWY7tr|A0A1Y4GAW6|A0A1Y4GAW6tr|R5EQE4|R5EQE4 tr|A0A1W2C069|A0A1W2C069tr|R6ICE0|R6ICE0N Ntr|A0A1Y3X475|A0A1Y3X475tr|A0A1Y3SF54|A0A1Y3SF54 domain-containing domain-containing 9FIRM@Lar protein@OS=candidate 9FIRM@Larprotein@OS=candidate9FIRM@Lar 9FIRM@Lar 9FIRM@Lar N N Ndomain-containing 9BACT@Lactate 9FIRM@Nickel-dependentN 9FIRM@Lactate domain-containing9FIRM@Lactatedomain-containingN domain-containing domain-containing division division MSBL1 MSBL1 racemizationarchaeon protein@OS=Eubacteriumracemizationarchaeonracemization protein@OS=Lachnospiraceae protein@OS=Lachnospiraceae protein@OS=Firmicutes protein@OS=Firmicutes SCGC-AAA259O05@GN=AKJ41 SCGC-AAA259A05@GN=AKJ57 lactate operon operonoperon racemase@OS=Papillibacter protein proteinprotein sp. LarA@OS=Cloacibacillus bacterium LarA@OS=Flavonifractorbacterium14-2@GN=C805LarA@OS=Flavonifractor bacterium bacterium 01570 02380 CAG CAG 3-1@GN=C806 A2@GN=C810 cinnamivorans 01274 sp. sp. An23@GN=B5F39sp. 01099 01871An52@GN=B5G06 An82@GN=B5G34DSM 12816@GN=SAMN02745168 09205 11700 14075 2481 tr|A0A0S7BGK7|A0A0S7BGK7tr|A0A0C7NUG6|A0A0C7NUG6 9CHLR@Uncharacterized 9THEO@Lar conserved N domain-containing protein@OS=Longilinea protein@OS=Moorella arvoryzae@GN=LARV glycerini@GN=3604 02455 tr|A0A1Y4RIF0|A0A1Y4RIF0tr|A0A0F0CDL9|A0A0F0CDL9 9FIRM@Lactate 9CLOT@Lar racemization N domain-containing operon protein protein@OS=ClostridiumLarA@OS=Lachnoclostridium sp. sp. FS41@GN=CLFS41 An14@GN=B5E84 3839011070 tr|A0A1Y4EY20|A0A1Y4EY20tr|A0A1G0YYY8|A0A1G0YYY8tr|A0A1Y4V9W2|A0A1Y4V9W2tr|A0A0S2W6M1|A0A0S2W6M1 9FIRM@Lartr|A0A1W6WBT2|A0A1W6WBT2 N domain-containing 9BACT@Lactate 9FIRM@Lactateprotein@OS=Blautia 9FIRM@Nickel-dependent 9FIRM@Lactate racemization racemization sp. An249@GN=B5F53 racemization operon operon lactate protein protein operon17910 racemase@OS=Intestinimonas LarA LarA@OS=Eubacterium protein Fragment@OS=Lentisphaerae LarA@OS=Ruminococcaceae sp. An11@GN=B5E53butyriciproducens@GN=C7373 bacterium bacterium GWF2 11375 52 CPB6@GN=B6259 8@GN=A2X49 10518 15435 01775 tr|D9QQC9|D9QQC9 ACEAZ@Lar N domain-containing protein@OS=Acetohalobium arabaticum strain ATCC 49924 / DSM 5501 / Z-7288@GN=Acear 1200 tr|A0A133UGV2|A0A133UGV2tr|A0A257AID8|A0A257AID8tr|A0A1G3PWN6|A0A1G3PWN6 9EURY@Lar tr|R6JZC7|R6JZC79ARCH@Lartr|R5F385|R5F385tr|A0A143Y1N1|A0A143Y1N1 N domain-containing N domain-containing 9CLOT@Lar 9SPIR@Lactate protein@OS=candidate protein@OS=Candidatus N domain-containing 9FIRM@Lar racemization division N Bathyarchaeota domain-containingoperonMSBL1 protein@OS=Clostridiumprotein@OS=Clostridium archaeonprotein archaeon LarA@OS=Spirochaetes SCGC-AAA259E19@GN=AKJ65 protein@OS=Eubacteriaceae ex4484 bolteae clostridioforme205@GN=B6U74 CAG bacterium CAG0630505465 GWF1 bacterium 41 5@GN=A2096 CHKCI004@GN=BN3660 01610 03342 tr|M5E390|M5E390tr|L0KB59|L0KB59 9FIRM@Lar HALHC@Lar N domain-containing N domain-containing protein@OS=Halanaerobium protein@OS=Halobacteroides saccharolyticum halobius strainsubsp. ATCC saccharolyticum 35273 / DSM DSM 5150 6643@GN=HSACCH / MD-1@GN=Halha 025211682 tr|A0A133UFV1|A0A133UFV1 9EURY@Lartr|A0A1G0YUT7|A0A1G0YUT7tr|R6GSR9|R6GSR9tr|E6MHQ0|E6MHQ0tr|A0A1H3Z4L9|A0A1H3Z4L9 N domain-containingtr|A0A1G9JX25|A0A1G9JX25 9FIRM@Larprotein@OS=candidate 9FIRM@Lar 9BACT@Lactate 9FIRM@Nickel-dependentN domain-containing N domain-containing 9FIRM@Nickel-dependentdivision MSBL1racemization archaeon protein@OS=Eubacterium protein@OS=Pseudoramibacter operon SCGC-AAA259E17@GN=AKJ64lactate protein racemase@OS=Eubacteriumlactate LarA@OS=Lentisphaerae racemase@OS=Halarsenatibacter hallii CAG 01500 alactolyticus aggregans@GN=SAMN04515656bacterium ATCC GWF2 23263@GN=HMP0721 silvermanii@GN=SAMN04488692 44 16@GN=A2017 10522 153511060 104111 tr|A0A151BP01|A0A151BP01 9ARCH@Transcriptional regulator@OS=Candidatus Bathyarchaeota archaeon B26-2@GN=AYL32 003710 tr|A0A1F8PIR1|A0A1F8PIR1tr|D7GUF0|D7GUF0tr|A0A0J1FIX8|A0A0J1FIX8 9CHLR@Lar 9FIRM@Uncharacterized N domain-containing 9FIRM@Lar protein@OS=Chloroflexi N domain-containingconserved protein@OS=butyrate-producing bacteriumprotein@OS=Peptococcaceae RBG 16 51 9@GN=A2Z28 bacterium bacterium 04685 SS3/4@GN=CK3 CEB3@GN=CEB3 17920 c07670 tr|A0A1M4XP56|A0A1M4XP56tr|A0A1H0BE22|A0A1H0BE22tr|Q24SB3|Q24SB3tr|G5IHC7|G5IHC7tr|F0GX25|F0GX25tr|A0A0U5NNC5|A0A0U5NNC5tr|R5IFQ9|R5IFQ9 DESHY@Lar 9CLOT@Lar 9CLOT@Nickel-dependent 9FIRM@Nickel-dependent 9FIRM@Lar N9CLOT@Lartr|A0A1E5G1H5|A0A1E5G1H5 domain-containing N domain-containing N domain-containing 9CLOT@LarN lactate domain-containing protein@OS=Desulfitobacterium lactate racemase@OS=Lactonifactor protein@OS=Hungatella Nracemase@OS=Megasphaera domain-containingprotein@OS=Anaerococcus protein@OS=Clostridium 9BACL@Lactate hathewayi protein@OS=Clostridiumlongoviformis hafniense paucivorans@GN=SAMN05660299 WAL-18680@GN=HMPREF9473prevotii racemizationstrain DSMsp. ACS-065-V-Col13@GN=HMPREF9290 CAG Y51@GN=DSY329017459@GN=SAMN02745158 sp. operon C105KSO13@GN=BN3456 protein 02905 02722 02060 LarA@OS=Desulfuribacillus 0710 00547 alkaliarsenatis@GN=BHF68 06320 tr|C0CW85|C0CW85tr|A0A1C0BLY4|A0A1C0BLY4tr|A0A0F0CI51|A0A0F0CI51tr|C2CK04|C2CK04tr|A0A1F2PJ74|A0A1F2PJ74 tr|A0A1Q9JXK7|A0A1Q9JXK79FIRM@Lar 9CLOT@Lactate N9FIRM@Lar domain-containing9CLOT@Lartr|A0A1B7LFA4|A0A1B7LFA4 9FIRM@Lar Nracemization domain-containingN domain-containing protein@OS= 9FIRM@Lactate N operon domain-containing asparagiformeprotein protein@OS=Anaerococcus protein@OS=Clostridium racemization LarA@OS=Clostridium9FIRM@Lactate protein@OS=AcetobacteriumDSM 15981@GN=CLOSTASPAR operon sp. proteinracemization sp.tetradius FS41@GN=CLFS41 W14A@GN=A7X67 LarA@OS=Anaerostipes ATCC wieringae@GN=ACWI 35098@GN=HMPREF0077 operon01239 0083002190 protein sp.LarA@OS=Desulfotomaculum 11280992a@GN=BHF69 1790 11830 copahuensis@GN=A6M21 09285 tr|I4BXH5|I4BXH5 ACEMN@Lar N domain-containing protein@OS=Acetomicrobium mobile strain ATCC BAA-54 / DSM 13181 / JCM 12221 / NGA@GN=Anamo 1373 tr|A0A1Y4CGP2|A0A1Y4CGP2tr|A0A1I5SWI2|A0A1I5SWI2tr|C5EM57|C5EM57tr|A0A0L6U1J7|A0A0L6U1J7tr|G8QYY5|G8QYY5tr|H6LBS3|H6LBS3tr|C0CX55|C0CX55tr|A0A1G0XEY5|A0A1G0XEY5tr|J4UEJ6|J4UEJ6 9FIRM@Lar 9FIRM@Nickel-dependent 9ACTN@SAF ACEWD@Lar SPHPG@Lar9FIRM@Lar Ntr|E1L7S0|E1L7S0 domain-containing 9FIRM@Lactate domain-containing 9FIRM@PF09861 NN domain-containingdomain-containing 9BACT@Lactate lactate protein@OS=Clostridialesracemization protein@OS=Olsenellaracemase@OS=Butyrivibrio 9FIRM@Lar family protein@OS=Sphaerochaetaprotein@OS=protein@OS=Acetobacteriumracemization operon protein@OS=Peptostreptococcaceae Nprotein sp.domain-containing operonasparagiformebacterium An285@GN=B5F79 proteoclasticus@GN=SAMN04487928LarA@OS=Acetobacterium protein 1 7 47FAA@GN=CBFG pleomorpha DSMwoodiiLarA@OS=Lentisphaerae 1023515981@GN=CLOSTASPAR strainprotein@OS=Veillonella strain ATCC bakii@GN=AKG39 ATCC 02735 29683 bacterium BAA-1885 107100 / DSMbacterium AS15@GN=HMPREF1142 1030 01576 /07570 DSM atypica /GWF2 JCM 22778 2381 45 ACS-049-V-Sch6@GN=HMPREF9321/ Grapes@GN=SpiGrapes14@GN=A2020 / KCTC 1655 1942/ WB1@GN=Awo 14715 3097 c08750 1752 tr|A0A0T5X9F1|A0A0T5X9F1tr|A0A1T4K1Y0|A0A1T4K1Y0 9BACT@Lar N domain-containing 9FIRM@Nickel-dependent protein@OS=Acetomicrobium lactate racemase@OS=Selenihalanaerobacter hydrogeniformans ATCC BAA-1850@GN=HMPREF1705 shriftii@GN=SAMN02745118 03640 00562 tr|A0A0S8CHW1|A0A0S8CHW1tr|A0A174G6C2|A0A174G6C2tr|U2MZ67|U2MZ67 9CHLR@Lartr|A0A1Y4LPG1|A0A1Y4LPG1tr|A0A1M7AFY5|A0A1M7AFY5tr|C4IIM9|C4IIM9 N domain-containing 9CLOT@Nickel-dependenttr|A0A259UCL7|A0A259UCL7 tr|R5FRX2|R5FRX2TRESO@PF09861tr|W3Y1K9|W3Y1K9tr|U5RZE9|U5RZE9 protein@OS=Dehalococcoidia CLOBU@Transcriptional family lactate 9FIRM@Lar protein@OS=Treponema 9FIRM@Lactate 9FIRM@Nickel-dependent racemase@OS=Hungatella 9FIRM@PF09861tr|C4F9L8|C4F9L8 9FIRM@Lar 9CLOT@Lar bacterium N regulator@OS=Clostridium domain-containing racemizationSG8 N 51socranskii domain-containing 3@GN=AMJ70N hathewayi@GN=larA familydomain-containing lactate9ACTN@Lar operonsubsp. protein@OS=Veillonella protein@OS=Coprobacillus 04210racemase@OS=Anaerocolumna socranskii protein butyricum protein@OS=Sporomusa N LarA@OS=Pseudoflavonifractor VPI domain-containingprotein@OS=Clostridium DR56BR1116 E4 str. BoNT sp. = ATCC AS16@GN=HMPREF1521sp. E BL5262@GN=CLPCAG jejuensis35536@GN=HMPREF1325 acidovoransprotein@OS=Collinsella autoethanogenum sp.DSM An184@GN=B5F19 DSM15929@GN=SAMN02745136 2265 3132@GN=SPACI 21361027 DSM intestinalis 02195 10061@GN=CAETHG 46590 DSM 04851 13280@GN=COLINT 2534 02752 tr|G7V938|G7V938tr|A0A1N6VHD2|A0A1N6VHD2 THELD@Lar N domain-containing 9FIRM@Nickel-dependent protein@OS=Thermovirga lactate racemase@OS=Halanaerobium lienii strain ATCC BAA-1197 kushneri@GN=SAMN05421834 / DSM 17291 / Cas60314@GN=Tlie 10810 1863 tr|L0F2W9|L0F2W9tr|U2CIS8|U2CIS8tr|F7KF85|F7KF85tr|A0A1V2M458|A0A1V2M458tr|A6P1C6|A6P1C6tr|R5T9K5|R5T9K5tr|A0A1I3NR88|A0A1I3NR88 DESDL@Lartr|D9QS13|D9QS13tr|M5E396|M5E396 9CLOT@Lar9FIRM@Lartr|A0A0U1KSH1|A0A0U1KSH1tr|R6XTB0|R6XTB0 9CLOT@Lar9FIRM@Lar N domain-containing N 9FIRM@Lactatedomain-containing 9FIRM@Nickel-dependenttr|A0A0U9HMP9|A0A0U9HMP9tr|A0A1W1XIH8|A0A1W1XIH8 NN domain-containing9FIRM@Noveldomain-containingACEAZ@Lar protein@OS=Desulfitobacterium 9FIRM@Lar racemization protein@OS=Clostridiumprotein@OS=Lachnospiraceae Ntr|G1WI29|G1WI29 D-mannonate9FIRM@Novel domain-containingprotein@OS=Clostridium protein@OS=Pseudoflavonifractor lactateN operon domain-containing racemase@OS=Ruminococcaceae protein dehydrogenase@OS=Halanaerobium dichloroeliminansD-mannonatesp. 9CLOT@Nickel-dependentLarA@OS=Epulopiscium 9THEO@Nickel-dependent KLEprotein@OS=Acetohalobium bacterium9ACTN@Lar hathewayi 1755@GN=HMPREF1548 protein@OS=Firmicutes 3 straindehydrogenase@OS=Sporomusa 1capillosusCAG 57FAA LMG N sp.CT1@GN=HMPREF0994 P-21439domain-containing ATCC SCG-B11WGA-EpuloA1@GN=AN396bacterium 05078 29799@GN=BACCAP/ DCA1@GN=Desdi lactatearabaticum lactateD5@GN=SAMN02910435 bacterium saccharolyticum racemase@OS=Clostridium racemase@OS=Tepidanaerobacter strain04373 protein@OS=CollinsellaCAG 0660 ATCCsp.04293 subsp. An4@GN=SpAn4DRAFT 49924 13180 01372 saccharolyticum / DSM 5501 acidisoli tanakaei / Z-7288@GN=AcearDSM 1316 DSM6643@GN=HSACCH syntrophicus@GN=TSYNT YIT 12555@GN=SAMN02745134 12063@GN=HMPREF9452 1799 02269 7171 0195200992 tr|A0A1I4GYC9|A0A1I4GYC9 9FIRM@Nickel-dependent lactate racemase@OS=Halanaerobium salsuginis@GN=SAMN02983006 00914 tr|V7I7K2|V7I7K2tr|A0A1M6IQD9|A0A1M6IQD9tr|A0A1Y4C0W4|A0A1Y4C0W4tr|A0A1Y4VYW4|A0A1Y4VYW4tr|A0A1Y4WEG2|A0A1Y4WEG2tr|A0A1G9U0I7|A0A1G9U0I7tr|A0A1N6T9U7|A0A1N6T9U7tr|G9YHE4|G9YHE4tr|A0A259UW32|A0A259UW32 9CLOT@Lactatetr|B0TE13|B0TE13tr|A0A0B3W1C9|A0A0B3W1C9tr|F4LQZ4|F4LQZ4tr|A0A0H3J6I1|A0A0H3J6I1 racemization 9FIRM@Lar HELMI@Lar 9FIRM@Nickel-dependenttr|R5ZBX7|R5ZBX7 9FIRM@Nickel-dependent 9FIRM@Lactatetr|R7D4F5|R7D4F5 9FIRM@Lactate9FIRM@Nickel-dependent9FIRM@Lactate operon 9FIRM@LarN domain-containing TEPAE@Lar proteinN domain-containing LarA@OS=Youngiibacter racemization 9FIRM@Lactateracemization racemization CLOPA@LarN domain-containing 9ACTN@Lar9ACTN@LarN lactatedomain-containingprotein@OS=Anaeroglobuslactate lactate operon operon operonprotein@OS=Heliobacterium racemase@OS=Dethiosulfatibacter Nracemase@OS=Megasphaera racemase@OS=Halanaerobium racemizationdomain-containing protein fragilis protein protein NN protein@OS=Sporomusa domain-containingdomain-containing 232.1@GN=T472 LarA@OS=Flavonifractor LarA@OS=FlavonifractorLarA@OS=Flavonifractor protein@OS=Tepidanaerobacter operon geminatus protein@OS=Clostridium protein 0204260 modesticaldum protein@OS=Collinsellaprotein@OS=Collinsella paucivorans@GN=SAMN05660299 F0357@GN=HMPREF0080LarA@OS=Terrisporobacter acidovoranskushneri@GN=SAMN05421834 aminovoranssp. sp.sp. An306@GN=B5F88 An100@GN=B5E43An10@GN=B5E42 strain DSM DSM ATCC acetatoxydans3132@GN=SPACIpasteurianum 17477@GN=SAMN02745751 51547 sp. sp.0764013285 13940 01073 CAG CAG othiniensis@GN=QX51/ Ice1@GN=HM11056 01074 DSMstrain 15730 525 DSM = ATCC21804 1638 02396 6013@GN=CLPA /00655 JCM 16047 / Re1@GN=TEPIRE1 c14440 2177 tr|D5EFU1|D5EFU1 AMICL@Lar N domain-containing protein@OS=Aminobacterium colombiense strain DSM 12261 / ALA-1@GN=Amico 1304 tr|R6QSL7|R6QSL7tr|A0A154BNC9|A0A154BNC9tr|A6TUJ7|A6TUJ7tr|J6H3I8|J6H3I8tr|C2BGC5|C2BGC5tr|T2RGG7|T2RGG7tr|A0A1G9QBF9|A0A1G9QBF9tr|Q18B34|Q18B34tr|R5XRL9|R5XRL9tr|K6TRA1|K6TRA1tr|A0A1V4ISB0|A0A1V4ISB0tr|U5MSB7|U5MSB7tr|R4KF62|R4KF62tr|M1MI77|M1MI77tr|G7MAY5|G7MAY5tr|A0A1S8TPF9|A0A1S8TPF9 9FIRM@Lartr|A0A095VPZ1|A0A095VPZ1 9FIRM@PF09861 ALKMQ@Lar 9FIRM@LarWeissella CLOD6@Lar NPAESO@Lar 9CLOT@LarANASB@Lactate domain-containing 9CLOT@Lar CLOPA@Lar 9CLOT@Lar CLOSA@LarN 9CLOT@LarN domain-containing familydomain-containing 9FIRM@Nickel-dependent N 9CLOT@LarNN domain-containing protein@OS=Peptoanaerobacter domain-containingdomain-containing N racemization N 9CLOT@Larprotein@OS=AnaerostipesNdomain-containing N domain-containing 9GAMM@LactateNdomain-containing domain-containing domain-containing protein@OS=Alkaliphilus Nprotein@OS=Anaerococcus domain-containingoperonhellenica N protein@OS=Clostridioides protein@OS=Paeniclostridiumdomain-containingprotein@OS=Clostridium proteinlactate protein@OS=Clostridium protein@OS=Clostridiumracemization protein@OS=Clostridium protein@OS=Clostridium sp.protein@OS=Clostridium LarA@OS=Anaerosporomusa racemase@OS=Romboutsia CAG stomatis@GN=HMPREF1143 protein@OS=Clostridium metalliredigens operonprotein@OS=Clostridium lactolyticus bartlettiidifficile proteinR-53116@Protein sordelliisp. strainpasteurianumATCC saccharoperbutylacetonicum strainMaddingleyCAGsaccharobutylicum LarA@OS=Tatumellasp. QYMF@GN=Amet subterranea@GN=AXX12ATCC51172@GN=HMPREF0072 DL-VIII@GN=CDLVIIIlituseburensis630@GN=CD630 chromiireducens@GN=CLCHR 1632 9714@GN=H477 BC1@GN=ClopaMBC34-26@GN=A370puniceum@GN=CLPUN DSM DSM 3746 11700morbirosei@GN=HA49 797@GN=SAMN04515677 13864@GN=CLSA 0154400812335 N1-4HMT@GN=Cspa 3455 1395 03086 16350 18760 c25170 04200 105114c08140LarA@GeneID GA0061075 RS03125 Desguin2017 tr|E4RNY1|E4RNY1tr|A0A1C0A802|A0A1C0A802 HALHG@Lar N domain-containing 9FIRM@Transcriptional protein@OS=Halanaerobium regulator@OS=Orenia hydrogeniformans@GN=Halsa metallireducens@GN=U472 0182 10200 tr|A0A2H9HYY1|A0A2H9HYY1tr|A0A256YZR7|A0A256YZR7tr|A0A151BNZ3|A0A151BNZ3tr|A0A151BM19|A0A151BM19tr|A0A1D9FIQ7|A0A1D9FIQ7tr|A0A0G3W9I8|A0A0G3W9I8 9ARCH@Lar9ARCH@Lactate9ARCH@Lartr|A0A133SKH1|A0A133SKH1tr|A0A1Y4CLF2|A0A1Y4CLF2tr|G0VMP5|G0VMP5tr|A0A0J6WU40|A0A0J6WU40sp|D9TQ02|LARAtr|A0A1G9UTZ4|A0A1G9UTZ4tr|G5GIE4|G5GIE4 NN domain-containingdomain-containing tr|A0A0A8VUH1|A0A0A8VUH1racemizationracemizationtr|U5RP34|U5RP34tr|A0A0M3DJF5|A0A0M3DJF5tr|A0A037ZAL6|A0A037ZAL6tr|A0A1J0GEA5|A0A1J0GEA5tr|A0A255I5P4|A0A255I5P4tr|A0A0L6Z8Z4|A0A0L6Z8Z4tr|A6LWC1|A6LWC1tr|A0A239JX32|A0A239JX32tr|A0A1D9FIQ6|A0A1D9FIQ6 9CLOT@Lactate 9CLOT@Lar operonTHETC@Lactateoperon MEGEL@Lar protein@OS=Candidatusprotein@OS=Candidatustr|C2BEV7|C2BEV7tr|C2CK52|C2CK52 tr|A0A095ZI57|A0A095ZI579FIRM@Lar proteinproteintr|D3R2Q4|D3R2Q4 N 9FIRM@Lar9FIRM@Lactate domain-containingLarA@OS=Candidatus LarA@OS=Candidatus9FIRM@Lactate9CLOT@Larracemization 9FIRM@Nickel-dependent N domain-containing CLOB8@Larracemase@OS=Thermoanaerobacterium N domain-containing Bathyarchaeota Bathyarchaeota CLOTT@LarN9FIRM@LactateoperonPAESO@Lar9FIRM@Nickel-dependent domain-containing 9CLOT@Lar9CLOT@LactateN protein@OS=Clostridiumracemization9FIRM@Lar9FIRM@Nickel-dependent racemizationdomain-containingBathyarchaeota 9CLOT@Lactate BathyarchaeotaproteinMAGIU@Lar N archaeon archaeondomain-containing protein@OS=MegasphaeraLarA@OS=Clostridium 9FIRM@LactateNN domain-containing domain-containing N operonarchaeonprotein@OS=Johnsonella lactateracemizationB26-2@GN=AYL32 archaeonoperonB26-1@GN=AYL31N domain-containing protein@OS=Megasphaeradomain-containing racemizationN domain-containingproteinB24-2@GN=CP083 racemase@OS=Dendrosporobacterracemization protein@OS=Clostridiumaceticum@GN=CACETex4484protein lactate 40@GN=B6U84operon LarA@OS=Megasphaera formicaceticum@GN=BJL90protein@OS=Clostridium004650 LarA@OS=Megasphaeraracemization005950 lactate thermosaccharolyticumoperonprotein@OS=Clostridiumprotein@OS=Paeniclostridium racemase@OS=Lachnotalea 04940proteinoperonelsdeniiprotein@OS=Clostridium racemase@OS=Anaerovirgulaprotein@OS=Anaerococcus 01400ignavaprotein c19130protein@OS=Mageeibacillus LarA@OS=Paraclostridium DSMsp.proteinoperon MJR8396C@GN=HMPREF3201ATCC autoethanogenum LarA@OS=Clostridium20460@GN=MELS LarA@OS=Clostridium protein04880sp. 51276@GN=HMPREF9333cerevisiae strain beijerinckiiAn286@GN=B5F80quercicolus@GN=SAMN04488502 tetanomorphum LarA@OS=TissierelliaATCC homopropionicum DSMsordellii@GN=JGS6382glycerini@GN=larA DSM7956 strain2220 20462@GN=AB840tetradiuslactolyticus benzoelyticum@GN=VN21multivorans@GN=SAMN05446037 /10061@GN=CAETHG estertheticum indolicusDSMATCC DSM10490 formicaceticum@GN=BJL90 00304571 ATCC 51743 665@GN=CTM 01334DSMATCC /strain NCIB bacterium 35098@GN=HMPREF0077 subsp.5847@GN=CLHOM /1226020931 NCIMB 51172@GN=HMPREF0072938510663UPII9-5@GN=HMPREF0868 estertheticum@GN=A7L45/ 0247NCAS5-A11@GN=HMPREF1633 8052@GN=Cbei02034 02980 3814@GN=larA 04475 10402622300 2495 1862 0877 1179 05825 14365 tr|A0A1T4R8U6|A0A1T4R8U6tr|A0A1W9VRK1|A0A1W9VRK1 9FIRM@Nickel-dependent 9BACT@Lar N lactate domain-containing racemase@OS=Carboxydocella protein@OS=Candidatus sporoproducens Atribacteria DSM bacterium 16521@GN=SAMN02745885 4572 76@GN=B6228 03940 01992 tr|A0A285BES1|A0A285BES1tr|F7NIL5|F7NIL5tr|A0A1G5K962|A0A1G5K962tr|A0A137SR13|A0A137SR13tr|C9LYY4|C9LYY4tr|W3Y3D2|W3Y3D2tr|A0A174C6H6|A0A174C6H6tr|A0A0A7FYC2|A0A0A7FYC2tr|W6N309|W6N309tr|A0A1M4XXD5|A0A1M4XXD5tr|A0A151ANH5|A0A151ANH5tr|U2CZZ8|U2CZZ8tr|R1CEZ8|R1CEZ8tr|A0A099S1Z7|A0A099S1Z7tr|U2NQJ0|U2NQJ0 9FIRM@Lar SELS3@Lar 9FIRM@PF09861 CLOTY@Novel 9FIRM@Nickel-dependent N 9FIRM@Lar 9CLOT@Putative 9CLOT@Nickel-dependent 9CLOT@Lar domain-containing9FIRM@Lar N CLOVE@Domain 9CLOT@Lardomain-containing 9CLOT@Lactate 9CLOT@Lar9CLOT@Nickel-dependent N familyND-mannonate Ndomain-containing domain-containingdomain-containing D-mannonate protein@OS=Acetonema protein@OS=Veillonella N N lactatedomain-containing domain-containingof lactateprotein@OS=Selenomonasracemization uncharacterizeddehydrogenase@OS=Clostridium racemase@OS=Thermoanaerobacterium dehydrogenase@OS=Caldisalinibacter racemase@OS=Alkaliphilus protein@OS=Clostridiales protein@OS=Clostridium lactate operon longumprotein@OS=Clostridium sp. protein@OS=Clostridiumracemase@OS=Clostridiumfunction AS16@GN=HMPREF1521 protein DSM DUF2088@OS=Clostridium sputigena LarA@OS=Clostridium6540@GN=ALO bacterium peptidifermentans bacteriumintestinaletyrobutyricum strain baratii sp. ATCC KA00134@GN=HMPREF3189colicanis 09589 RBIITD@GN=SAMN05660242kiritimatiensis@GN=L21THoral URNW@GN=CINTURNWfallax@GN=SAMN05443638 1029 str. 35185DIVETGP@GN=CTDIVETGP taxon DSM Sullivan@GN=U729 sp.DSM ventriculi@GN=ERS852473 /HMP27@GN=DP68 876 18978@GN=SAMN03080606DSM 13634@GN=CLCOL str. 20758 F0540@GN=HMPREF1982 / VPI 1766 1587015241083 D19B-28@GN=Selsp1074 1222 12520 053113130 01849 03321 04518 1967 tr|A0A1Y1S0E9|A0A1Y1S0E9 9SPIO@Transcriptional regulator@OS=Marispirochaeta aestuarii@GN=B4O97 05735 tr|A0A1T4P4M5|A0A1T4P4M5tr|E1L710|E1L710tr|R5BLQ0|R5BLQ0tr|D1BMQ8|D1BMQ8tr|A5I0J8|A5I0J8tr|A0A162SF81|A0A162SF81tr|A0A1H6Y5D8|A0A1H6Y5D8tr|V7HV90|V7HV90tr|B7C8J0|B7C8J0tr|R6GT64|R6GT64tr|A0A2A7MDP1|A0A2A7MDP1tr|C0W5X2|C0W5X2 9FIRM@Lar CLOBH@Lar tr|R2XPE8|R2XPE89FIRM@Lartr|A0A0R1VLF1|A0A0R1VLF1 VEIPT@Lartr|A0A0R2FC96|A0A0R2FC96tr|A0A069CVP8|A0A069CVP8tr|A0A0R2D3Y9|A0A0R2D3Y9tr|A0A0R2B9P1|A0A0R2B9P1tr|A0A0R1MD20|A0A0R1MD20tr|A0A0R1MGW8|A0A0R1MGW8tr|A0A0R1HM67|A0A0R1HM67tr|Q03PG0|Q03PG0 9FIRM@Nickel-dependenttr|A0A0R1VIB8|A0A0R1VIB8 N Ndomain-containingN 9CLOT@LarN 9FIRM@Lar domain-containing9LACO@LarA domain-containing 9FIRM@Lardomain-containing 9ACTO@Lar 9ENTE@Lar 9FIRM@Nickel-dependent NLACBA@Lar N9CLOT@DUF2088 Ndomain-containing domain-containing protein@OS=Lactobacillus protein@OS=Veillonelladomain-containinglactate Nprotein@OS=Veillonella protein@OS=Clostridium 9LACO@Larprotein@OS=Veillonelladomain-containing 9LACO@Lar WEIOS@LactateNLACCL@Lar9LACO@Lar 9LACO@Lar racemase@OS=Garciella9LACO@Lardomain-containing9LACO@Lar 9LACO@Lar N domain-containing protein@OS=Clostridiumdomain-containingN protein@OS=Holdemanella N Nprotein@OS=Eubacteriumdomain-containingN lactate N domain-containing Ndomain-containingNdomain-containing atypicaprotein@OS=ActinomycesNdomain-containing racemization domain-containingdomain-containingsp. domain-containingparvula botulinumprotein@OS=Enterococcusequiracemase@OS=PropionispiraCAG ACS-049-V-Sch6@GN=HMPREF9321 nitratireducens DPC protein@OS=Lactobacillusstrain protein@OS=Clostridium strain operon6820@GN=LEQ ATCCprotein@OS=Lactobacillus protein@OS=Lactobacillusmagnum protein@OS=Lactobacillusprotein@OS=Lactobacillus Hallprotein@OS=Lactobacillus protein@OS=Lactobacillus DSM 10790protein@OS=Lactobacillusprotein halliibiformis / ATCC 15102@GN=SAMN02745973DSM urogenitalis /CAG DSM LarA@OS=Weissella 3502DSM0906c2767@GN=CLMAG gilvus 2008arboris@GN=SAMN05660742 /3989@GN=EUBIFOR NCTCneonatale@GN=CQ394brevis /ATCCDSM JCM 0708 ghanensis13319 strain15434@GN=HMPREF0058 12972 similis BAA-350@GN=UKCcollinoidesaquaticus oeni kimchicusghanensis capillatus/ 29220ATCC/ Type oryzae Te3@GN=VparDSM DSM01925 DSM A@GN=CBO1006 DSM DSM367 23365 19972@GN=FD46 00494 JCM strainDSM DSM18630@GN=FC89 14055 / 21051@GN=FC19 20515JCM 1063415530@GN=FC96 = 18630@GN=FC89DSM19910@GN=FC81 0984 JCM00954 1170@GN=LVIS = 25784 JCM 2765@GN=FD141266 1123@GN=FC82 GL000654/ JCMGL001045 GL002070 GL002066 18191GL001736GL001851 1849 GL003186 / SG25@GN=larA GL003223 tr|C8W3B1|C8W3B1tr|D7CMD1|D7CMD1 DESAS@Lartr|A0A1J5GIX8|A0A1J5GIX8 SYNLT@Lar N domain-containing N domain-containing 9BACT@Transcriptional protein@OS=Desulfofarcimen protein@OS=Syntrophothermus regulator@OS=Candidatus acetoxidans lipocalidus strain Atribacteria strain ATCC DSM 49208 bacterium12680 / DSM / TGB-C1@GN=Slip 771CG2 / 30VKM 33 B-164413@GN=AUK42 1088 / 5575@GN=Dtox 07240 0989 tr|C6PWC4|C6PWC4tr|A0A1S8LQN0|A0A1S8LQN0tr|V6IWP2|V6IWP2tr|Q97KZ7|Q97KZ7tr|R2Y3R5|R2Y3R5tr|Q03DK7|Q03DK7tr|W6TAH0|W6TAH0tr|A0A0R1GMH5|A0A0R1GMH5tr|T0TRK2|T0TRK2tr|C8NIN1|C8NIN1tr|A0A192H0S6|A0A192H0S6tr|Q38XJ2|Q38XJ2tr|I8R8X4|I8R8X4tr|D0BLP2|D0BLP2tr|G8PBT8|G8PBT8tr|A0A0R1RW55|A0A0R1RW55tr|A0A0R2ALC4|A0A0R2ALC4tr|A0A1I2TDU6|A0A1I2TDU6tr|A0A0R2MUM7|A0A0R2MUM7tr|A0A0U1QRT3|A0A0U1QRT3tr|A0A0R1HNE3|A0A0R1HNE3tr|A0A0R1XL08|A0A0R1XL08tr|A0A0R2FR21|A0A0R2FR21 9CLOT@Lar 9BACL@LactateCLOAB@Uncharacterized 9ENTE@Lar PEDPA@Lar 9LACT@LarLACPE@Lactate9STRE@Putative LACSS@Lar 9LACT@Lar9LACO@LactatePEDCP@Lar N domain-containing 9CLOT@Lar 9LACO@Lactate N 9BACL@Nickel-dependent NN9LACO@Lar racemization 9LACO@Lardomain-containing N9LACO@Lardomain-containing domain-containingN 9BACL@Lactate 9LACO@Lar domain-containing racemization domain-containingD-mannonate9LACO@Lar racemization N protein@OS=Clostridiumconserveddomain-containing Noperon N Ndomain-containingracemization Ndomain-containing domain-containingoperon N domain-containing dehydrogenase@OS=Streptococcus operonprotein@OS=Enterococcusracemization protein@OS=Granulicatellaprotein@OS=Pediococcusprotein@OS=Clostridiumproteindomain-containing protein@OS=Granulicatella protein@OS=Lactobacillusprotein@OS=Pediococcus protein lactate protein LarA@OS=Sporolactobacillus protein@OS=Clostridiumoperon LarA@OS=Lactobacillus operoncarboxidivoransracemase@OS=Sporolactobacillus LarA@OS=Lactobacillusprotein@OS=Lactobacillus protein@OS=Lactobacillus protein@OS=Lactobacillusprotein protein@OS=Lactobacillusprotein@OS=Lactobacillus protein@OS=Lactobacillusprotein LarA@OS=Lactobacillus acetobutylicum gilvuspentosaceus LarA@OS=SporolactobacillusadiacensP7@GN=CcarbDRAFT clausseniisakeielegans ATCCroseum@GN=CROST sp.subsp. laevolacticuspentosusATCC ATCC HSISM1@GN=HSISM1fabifermentans BAA-350@GN=UKC strainstrain bifermentans ozensissakei fuchuensiscomposti49175@GN=HMPREF0444 700633@GN=HMPREF0446algidussaniviri ATCCATCC KCA1@GN=larAmali@GN=IV36 nakayamae@GN=SAMN02982927backii@GN=ACX53strain DSM3091 DSM 824BAA-344DSM25745 JCMDSM T30PCM01@GN=LFAB 23K@GN=LCADSM33440442@GN=P343 23829/ DSM inulinus1747115638@GN=FC66 18527/ 01132CCUG20003@GN=FC0714340 / 79213 DSM=GL000964 = JCM =CASD@GN=SINU DSM / = 21536JCM JCM 14800 05220JCM 17196@GN=FD06 078413750 1776 24301@GN=IV56 14202@GN=FC831419 00895 /11249@GN=FC69 /LMG JCM GL000931 /01270 GL001921LMG 10740 18046 02185 571002495 / /183-1w@GN=PEPE KCTCGL000330 /GL000389 VKMGL001481 GL000368 3811 B-1787@GN=CA / P06@GN=PECL 1694 C0769 1783 tr|A0A1M6QUW0|A0A1M6QUW0tr|K8DZV8|K8DZV8tr|A0A1M4XBA8|A0A1M4XBA8 9FIRM@Nickel-dependent 9FIRM@Lar 9FIRM@Nickel-dependentNtr|A0A117LLZ3|A0A117LLZ3 domain-containing lactate racemase@OS=Desulfotomaculum protein@OS=Desulfotomaculum lactate 9BACT@Lar racemase@OS=Desulfotomaculum N domain-containing hydrothermale aeronauticum protein@OS=Atribacteria Lam5 DSMputei 10349@GN=SAMN02745123DSM= DSM 12395@GN=SAMN02745133 18033@GN=DESHY bacterium 34 50005128@GN=XD79 01213 01385 0167 tr|I0GT28|I0GT28tr|J3JAZ0|J3JAZ0tr|A0A0R2MAX9|A0A0R2MAX9sp|F9USS9|LARALactobacillusLactobacillusWeissellaLactobacillus SELRL@Lar 9LACO@Lar LACPL@Lactate N domain-containing N 9LACO@Lar domain-containing racemase@OS=Lactobacillus oryzae Nprotein@OS=Selenomonasequi domain-containing protein@OS=Lactobacillus similis fermentumbrevis DPCSG25@Protein plantarumprotein@OS=Lactobacillus ruminantium strain6820@ProteinDSM coryniformisNPS-QW-145@Protein ATCC subsp. BAA-793 subsp.lactilytica xiangfangensis@GN=IV64CECT23365@Protein /coryniformis NCIMB strain NBRC 8826 CECT /103574 5716@ProteinLarA@GeneIDWCFS1@GN=larA 5711@GN=A11Y GL002476 / TAM6421@GN=SELRLarA@GeneID 117835 22070LarA@GeneID LarA@GeneID LarA@GeneIDTT13 LEQ RS09675 RS07405 FD14 A6F53 LC40Desguin2017 RS03400 Desguin2017 11030 RS09865 Desguin2017 Desguin2017 Desguin2017 tr|F6DKU3|F6DKU3tr|F6B3P4|F6B3P4 DESCC@LarDESRL@Lar NN tr|Q67NT5|Q67NT5domain-containingdomain-containing protein@OS=Desulfotomaculumprotein@OS=Desulfotomaculum SYMTH@Lar N domain-containing ruminisnigrificans protein@OS=Symbiobacterium strain strain ATCC DSM 23193 14880 / DSM / VKM 2154 thermophilum B-2319 / NCIMB / CO-1-SRB@GN=Desca 8452strain / DL@GN=DesruT / IAM 14863@GN=STH1673 2368 3370 EnterococcusPediococcusLactobacillusGranulicatellaLactobacillusEnterococcusLactobacillusLactobacillus pentosaceus gilvus plantarum sakeiadiacensfaecalissaniviri mali 23K@ProteinATCC DSM JCMOG1RF@Protein ATCC WCFS1@Protein ATCC20444@ProteinBAA-350@Protein 17471@Protein 49175@Protein 25745@Protein LarA@GeneID LarA@GeneID LarA@GeneIDLarA@GeneID LarA@GeneID LarA@GeneID LarA@GeneID LarA@GeneID LCA RS03965 OG1RF lpFD00 IV560104I592 HMPREF0444 RS07930 PEPE RS01695 Desguin2017 RS04705 RS13935Desguin2017 RS08225 Desguin2017 Desguin2017 Desguin2017 RS04440 Desguin2017 Desguin2017 tr|A0A1I2QFV5|A0A1I2QFV5tr|A0A1S6IU24|A0A1S6IU24 9FIRM@Nickel-dependent 9FIRM@Lar lactate Nracemase@OS=Desulfotomaculum domain-containing protein@OS=Desulfotomaculum arcticum DSM 17038@GN=SAMN05660649 ferrireducens@GN=B0537 0368001222 tr|A0A1Z5HVR7|A0A1Z5HVR7 9THEO@Lar N domain-containing protein@OS=Calderihabitans maritimus@GN=KKC1 26290 tr|F4LSK1|F4LSK1tr|A0A1G5S640|A0A1G5S640 TEPAE@Lartr|A0A1F9WX23|A0A1F9WX23 N 9FIRM@Nickel-dependentdomain-containing protein@OS=Tepidanaerobacter9BACT@Lar lactate N racemase@OS=Acidaminobacter domain-containing acetatoxydans protein@OS=Elusimicrobia strain hydrogenoformans DSM 21804 bacterium / JCMDSM RIFOXYA2 160472784@GN=SAMN03080599 / Re1@GN=TEPIRE1 FULL 40 6@GN=A3J83 244203040 01880 tr|A0A1F5CNX5|A0A1F5CNX5 9ARCH@Lar N domain-containing protein Fragment@OS=Candidatustr|A0A1F9XLF6|A0A1F9XLF6tr|R4KR17|R4KR17 Bathyarchaeota 9BACT@Uncharacterized 9FIRM@Lar archaeon N domain-containing RBG 16 protein@OS=Elusimicrobia 57 9@GN=A3K69 protein@OS=Desulfallas 03210 bacterium gibsoniae RIFOXYB2 DSM FULL 7213@GN=Desgi 48 7@GN=A2297 3678 01860 tr|A0A1F5DJW7|A0A1F5DJW7 9ARCH@Lar N tr|A0A1I4QFQ1|A0A1I4QFQ1domain-containingtr|C0D8L4|C0D8L4 protein@OS=Candidatus 9DELT@Nickel-dependent 9FIRM@Lar Bathyarchaeota N domain-containing lactate archaeon racemase@OS=Thermodesulforhabdus RBGprotein@OS= 13 52 12@GN=A3K78 asparagiforme 03325 DSM norvegica@GN=SAMN05660836 15981@GN=CLOSTASPAR 05613 00012 tr|A0A1Q9P9T1|A0A1Q9P9T1tr|A0A0M0BPR4|A0A0M0BPR4 9ARCH@Lar N domain-containing 9ARCH@Lar N domain-containingprotein@OS=Candidatustr|A0A1H4NZY3|A0A1H4NZY3 protein@OS=miscellaneoustr|A0A101VVA2|A0A101VVA2 Thorarchaeota 9BACL@Nickel-dependent archaeon Crenarchaeota AB 9FIRM@Lar 25@GN=ThorAB25 group-15lactate N domain-containing racemase@OS=Paenibacillus archaeon 04950 DG-45@GN=AC482 protein@OS=Gracilibacter sp. 03970 GP183@GN=SAMN05443246 sp. BRH c7a@GN=APF84 2645 11840 tr|A0A1F5DFF7|A0A1F5DFF7tr|A0A135VF99|A0A135VF99 9ARCH@Lar 9ARCH@Lartr|A0A2E8EEK9|A0A2E8EEK9 N Ndomain-containing domain-containing protein@OS=Candidatus 9ARCH@Lar protein@OS=Candidatus N domain-containing Bathyarchaeota Thorarchaeota protein@OS=Candidatus archaeon archaeon RBG SMTZ1-45@GN=AM325 13 38 Bathyarchaeota 9@GN=A3K80 archaeon@GN=CL67315010 06960 04945 tr|A0A1Q7MM43|A0A1Q7MM43tr|A0A151BHF5|A0A151BHF5 9ARCH@DUF20889CREN@Lar N domain-containing domain protein@OS=Candidatus protein@OS=Crenarchaeota Bathyarchaeota archaeon archaeon 13 1 40CM B25@GN=AYL30 3 52 17@GN=AUI97 001040 03810 tr|A0A1Q7M002|A0A1Q7M002tr|A0A2H9HY18|A0A2H9HY18 9CREN@Uncharacterized 9ARCH@Lar protein@OS=Crenarchaeota N domain-containing protein@OS=Candidatus archaeon 13 1 40CM Bathyarchaeota 3 53 5@GN=AUJ07 archaeon 00265 B24-2@GN=CP083 06100 tr|A0A1F3BKX2|A0A1F3BKX2 9ARCH@Uncharacterized protein@OS=archaeon RBG 16 50 20@GN=A3K71 02630 tr|A0A151BKA4|A0A151BKA4tr|A0A151BMW6|A0A151BMW6 9ARCH@DUF2088 9ARCH@DUF2088 domain domain protein@OS=Candidatus protein@OS=Candidatus Bathyarchaeota Bathyarchaeota archaeon archaeon B26-1@GN=AYL31 B26-2@GN=AYL32 007510 006680 tr|A0A1F5CYK0|A0A1F5CYK0tr|A0A151BK06|A0A151BK06 9ARCH@Lar 9ARCH@DUF2088 N domain-containing domain protein@OS=Candidatus protein@OS=Candidatus Bathyarchaeota Bathyarchaeota archaeon archaeon B26-1@GN=AYL31 RBG 13 46 16b@GN=A3K79 007520 04265 tr|A0A0M0C140|A0A0M0C140tr|A0A2H9LJQ7|A0A2H9LJQ7 9ARCH@Transcriptional9ARCH@Lar N domain-containing regulator@OS=Candidatus protein@OS=miscellaneous Bathyarchaeota Crenarchaeota archaeon group-6CG07 land archaeon 8 20 14 AD8-1@GN=AC479 0 80 47 9@GN=COS86 00200 06280 tr|A0A0S8JRK8|A0A0S8JRK8 9BACT@Lar N domain-containing protein@OS=candidate division BRC1 bacterium SM23 51@GN=AMJ85 01325 tr|A0A0M0BGW9|A0A0M0BGW9 9ARCH@Lartr|A0A0P9DV61|A0A0P9DV61tr|A0A0P9E4B7|A0A0P9E4B7 N domain-containing 9ARCH@Lar 9ARCH@Lar protein@OS=miscellaneous N Ndomain-containing domain-containing Crenarchaeota protein@OS=Candidatus protein@OS=Candidatus group archaeon Bathyarchaeota Bathyarchaeota SMTZ1-55@GN=AC480 archaeon archaeon BA1@GN=AOA65 04495BA2@GN=AOA66 1656 1617 tr|A0A1G1BTL3|A0A1G1BTL3 9BACT@Lar N domain-containing protein@OS=Lentisphaerae bacterium RIFOXYB12 FULL 65 16@GN=A3K19 12385 tr|A0A256XH96|A0A256XH96tr|A0A256ZG00|A0A256ZG00 9ARCH@Lar N domain-containing 9ARCH@Transcriptional protein@OS=Candidatus regulator@OS=Candidatus Altiarchaeales Bathyarchaeota archaeon ex4484 archaeon 96@GN=B6U97 ex4484 135@GN=B6U66 02515 04070 tr|A0A1J4VGY6|A0A1J4VGY6tr|A0A1G1ITX6|A0A1G1ITX6 9BACT@Lar 9BACT@Lar N N domain-containing domain-containing protein@OS=Omnitrophica protein@OS=Candidatus Omnitrophica bacterium GWA2 bacterium 41 15@GN=A2047 CG1 02 40 15@GN=AUJ70 02735 00970 tr|A0A256ZRA0|A0A256ZRA0tr|A0A256YPI1|A0A256YPI1 9ARCH@Transcriptional 9ARCH@Transcriptional regulator@OS=Candidatus regulator@OS=Candidatus Altiarchaeales Altiarchaeales archaeon archaeon ex4484 ex4484 2@GN=B6U72 43@GN=B6U86 00540 00545 tr|M5E0F3|M5E0F3tr|A0A1G1KJX4|A0A1G1KJX4 9FIRM@Transcriptional regulator@OS=Halanaerobium 9BACT@Lar N domain-containing saccharolyticum protein@OS=Omnitrophica subsp. saccharolyticum bacterium DSM RIFCSPLOWO2 6643@GN=HSACCH 12 FULL 01008 45 13@GN=A3G36 00655 tr|M7U6A3|M7U6A3 9EURY@Lar N domain-containing protein@OS=Thermoplasmatales archaeon SCGC AB-539-N05@GN=MBGDN05 00151 tr|A0A1W1VGZ5|A0A1W1VGZ5tr|A0A0J1FC28|A0A0J1FC28tr|A0A0C7N9Y1|A0A0C7N9Y1tr|A0A0S8DQV2|A0A0S8DQV2tr|A0A1G1PN92|A0A1G1PN92 9FIRM@Lar 9THEO@Nickel-dependent 9THEO@Lar 9BACT@Lar9BACT@Lar N domain-containing N domain-containing NN domain-containingdomain-containing lactate protein@OS=Peptococcaceae racemase@OS=Thermanaeromonas protein@OS=Moorella protein@OS=Omnitrophicaprotein@OS=Omnitrophica glycerini@GN=1237 bacterium WORWOR toyohensis CEB3@GN=CEB3 22 bacteriumbacterium ToBE@GN=SAMN00808754 RIFCSPLOWO2SM23 c2961029@GN=AMJ78 12 FULL 09775 510653 24@GN=A3F87 01235 tr|B4VPY2|B4VPY2tr|A0A1M3K9F3|A0A1M3K9F3tr|A0A1F8SNT5|A0A1F8SNT5tr|A0A1F8MIK0|A0A1F8MIK0tr|A0A1F8LR45|A0A1F8LR45tr|A0A1F8NE66|A0A1F8NE66tr|A0A1Q7HQJ4|A0A1Q7HQJ4tr|A0A1F8TNT1|A0A1F8TNT1 tr|A5UY73|A5UY739CYAN@Lartr|A0A1Q7MFR1|A0A1Q7MFR1tr|A0A1F8LBN2|A0A1F8LBN2 N domain-containing 9CHLR@Lar 9CHLR@Lar 9CHLR@Lar9CHLR@Lar 9CHLR@LarROSS1@Lar 9CHLR@Lar 9CHLR@LarN N NN9CHLR@Lar domain-containing domain-containingN9CHLR@Lar Ndomain-containingdomain-containing protein@OS=Coleofasciculus domain-containingdomain-containing N N domain-containingN domain-containing N domain-containing domain-containing protein@OS=Chloroflexiprotein@OS=Chloroflexi protein@OS=Chloroflexiprotein@OS=Chloroflexi protein@OS=Chloroflexiprotein@OS=Roseiflexus protein@OS=Chloroflexi chthonoplastesprotein@OS=Chloroflexi protein@OS=Chloroflexi protein@OS=Chloroflexi bacteriumbacterium bacteriumbacterium bacterium PCCsp. strain 7420@GN=MC7420 RBG44-23@GN=BGO78 RBGRBG bacterium RBG bacteriumRS-1@GN=RoseRS bacterium 13 bacterium 19FT13 1350 48 60 21@GN=A2Z71 COMBO RIFCSPLOWO2 10@GN=A2Y88 1313@GN=A2Y61 GWC2 131 40CM 15670 022704740CM 73 32159@GN=A2029 418@GN=A2X23 68 304345 120361070 4@GN=AUH8507200 FULL6@GN=AUJ06 71 08250 12@GN=A3G8401960 13700 00350 05810 tr|A0A1W9UIB1|A0A1W9UIB1OATZ014OATZ007OATZ030OATZ006NPISAOAOATZ023OATZ010tr|A0A1Q7QKW4|A0A1Q7QKW4 9CHLR@Lar v2 v1 tr|A0A238VAN3|A0A238VAN3v2 v1v2 N1850001410005 tr|V4ZTC9|V4ZTC9tr|R4W3K1|R4W3K11920005domain-containingtr|A0A1M5U4F0|A0A1M5U4F0v2 70037tr|M0CST0|M0CST0 1410006tr|J3JFE7|J3JFE7tr|L9WQ73|L9WQ73tr|D2RY35|D2RY35tr|A0A1Q1FF82|A0A1Q1FF82300006tr|A0A1G9TCJ1|A0A1G9TCJ1tr|A0A1G7MVG5|A0A1G7MVG5 tr|M0H486|M0H4869CHLR@Lartr|I3R893|I3R893 tr|A0A166SDT1|A0A166SDT1tr|A0A0W1SMD1|A0A0W1SMD1tr|A0A1N6Z6N1|A0A1N6Z6N1tr|L0K2C2|L0K2C2160004tr|A0A1G8U3U8|A0A1G8U3U8tr|F7PPX4|F7PPX4tr|U1PI70|U1PI70 protein@OS=Anaerolineaceae 9ARCH@LarN 9EURY@Lar9EURY@Lar IDdomain-containingHALVU@Nickel-dependent ID9EURY@Lar HALTV@Lar9EURY@Lar HALMT@DUF2088 9EURY@LarID ID9EURY@Lar 9EURY@Lar 67821542ID9EURY@Lar 9EURY@Nickel-dependent67823024 N IDN N67826845 9EURY@Lar9EURY@Nickel-dependentdomain-containing 63070930domain-containing domain-containingN 67828638 N9EURY@Nickel-dependent 9EURY@Lar 9EURY@Nickel-dependent 72348807domain-containing Ndomain-containing protein@OS=Chloroflexi9EURY@Lar Ndomain-containing9EURY@Nickel-dependent 67825041N domain-containing N domain-containingdomain-containing domain-containing N bacterium lactatedomain-containing N domain-containingprotein@OS=uncultured N protein@OS=Halogranumprotein@OS=Salinarchaeum domain-containingracemase@OS=Halorubrum protein@OS=Halosimplexprotein@OS=Haloterrigena protein@OS=Natronolimnobiuslactate 4572protein@OS=Haloferax putativeprotein@OS=Natronococcus putativelactate protein@OS=halophilicprotein@OS=Haloferaxputative protein@OS=Halorhabdus32.2@GN=B6I35lactate bacteriumracemase@OS=Halobaculumlactate larputative lactateprotein@OS=Halorientalis racemase@OS=HalogranumlarA racemase@OS=Halorientalisprotein@OS=Haladaptatus racemase@OS=HaladaptatuslarA protein@OS=Haloferax 13racemase@OS=Halovenusputative archaeon1 40CMsalarium 09420 larseniicarlsbadensesp. Nickel-dependent turkmenicavacuolatum@GN=SAMN06264855 archaeon 2mediterraneiHarcht-Bsk1@GN=L593 Nickel-dependentA07HB70@GN=A07HB70 Lactate70 innermongolicusLactateB-1@GN=HSB1 occultus Lactate JCMtiamatea6@GN=AUI58 sp.Lactategomorrense@GN=SAMN05443636 strain13917@GN=C455J07HX64@GN=J07HX64 2-9-1@GN=C475 sp.IM1011@GN=BV210gelatinilyticum@GN=SAMN04487949 strainsp.SP4@GN=Natoc SARL4B@GN=HLRTI regularis@GN=SAMN05216218 SB29@GN=AUR66 ATCC R4@GN=A4G99litoreus@GN=SAMN05421858aranensis@GN=SAMN05216226Nickel-dependent ATCCJCM 2610003075 51198 12255@GN=C493 3350003130 racemase 01577racemase 1293811825/racemase 2745DSM / DSM0643501555racemase102185 0156114020 5511003021 1411 / NCIMB16986 /2903 JCM 108801896 1716 10435132048866 lactate / /NBRC lactateVKMBINS BINSBINS B-1734@GN=Htur14739BINS / NCIMBlactate racemase 2177racemase 2912 / R-4@GN=HFX racemase 2777 BINS BINS BINS

tr|H1XXD1|H1XXD1tr|B8E201|B8E201tr|A0A1F8GPJ5|A0A1F8GPJ5tr|A0A127AMC1|A0A127AMC1 9BACT@Nickel-dependentDICTD@Lar N domain-containing 9BACT@Lar 9DELT@Lar lactate N protein@OS=Dictyoglomusracemase@OS=Caldithrix domain-containing N domain-containing protein@OS=Candidatus protein@OS=Candidatus abyssi turgidum DSM strain 13497@GN=Cabys Z-1310 Yanofskybacteria /Desulfofervidus DSM 6724@GN=Dtur 1100 bacterium auxilii@GN=HS1 RIFCSPLOWO20486 000396 01 FULL 49 17@GN=A2941 00340 tr|A0A2H9HZ22|A0A2H9HZ22tr|A0A0M0BDM2|A0A0M0BDM2tr|A0A1F3BBP3|A0A1F3BBP3tr|A0A151BDL9|A0A151BDL9 9ARCH@Lar 9ARCH@Lar 9ARCH@Lar BATXB@Transcriptional N domain-containing N N domain-containing domain-containing protein@OS=Candidatus regulator@OS=Bathyarchaeota protein@OS=miscellaneous protein@OS=archaeon Bathyarchaeota archaeonRBG Crenarchaeota 16 archaeon 50 strain 20@GN=A3K71 B24@GN=AYL29 B24-2@GN=CP083 group archaeon 05125 001600 SMTZ1-55@GN=AC480 06845 05650 tr|A0A1F8T0I4|A0A1F8T0I4tr|A0A1F8KJ81|A0A1F8KJ81tr|A0A1F8NP32|A0A1F8NP32tr|A0A1I5SJ79|A0A1I5SJ79 9CHLR@Lar 9CHLR@Lar 9CHLR@Lar N domain-containing N domain-containing N 9FIRM@Lar domain-containing protein@OS=Chloroflexi N domain-containingprotein@OS=Chloroflexi protein@OS=Chloroflexi protein@OS=Oscillibacter bacterium bacterium bacterium RBG GWB2 19FT RBG 54 COMBO sp.1336@GN=A2X24 66PC13@GN=SAMN05216343 10@GN=A2Z66 55 16@GN=A2Z45 06785 13900 05570 11291 tr|A0A2H9I138|A0A2H9I138tr|A0A2H9HZU8|A0A2H9HZU8 9ARCH@Lar 9ARCH@Lar N domain-containing N domain-containing protein@OS=Candidatus protein@OS=Candidatus Bathyarchaeota Bathyarchaeota archaeon archaeon B24-2@GN=CP083 B24-2@GN=CP083 00320 05220 tr|A0A1F4QE12|A0A1F4QE12tr|A0A257AG00|A0A257AG00 9BACT@Lar N domain-containing 9ARCH@Lar N protein@OS=candidatedomain-containing protein@OS=Candidatus division NC10 bacterium Bathyarchaeota RBG 16 65 8@GN=A2Z31archaeon ex4484 03730 205@GN=B6U74 07610 tr|A0A0S8CN25|A0A0S8CN25tr|A0A0F8VI20|A0A0F8VI20tr|R9N9L4|R9N9L4tr|D8PBA2|D8PBA2 9CHLR@Lar 9FIRM@Lar 9BACT@Lar LOKSG@Lar N Ndomain-containing domain-containing N domain-containing N domain-containing protein@OS=Dehalococcoidia protein@OS=Dorea protein@OS=Nitrospira protein@OS=Lokiarchaeum sp. 5-2@GN=C817 defluvii@GN=NIDE0743 bacterium sp. SG8 02423 strain 51 GC143@GN=AMJ70 75@GN=Lokiarch 00365 21910 tr|A0A2E8EDT0|A0A2E8EDT0tr|A0A1F5DQP4|A0A1F5DQP4tr|F0Z364|F0Z364 9CLOT@Putative 9ARCH@Lar 9ARCH@Lar N N domain-containingtranscriptional domain-containing regulator@OS=Clostridium protein@OS=Candidatus protein@OS=Candidatus sp. Bathyarchaeota D5@GN=HMPREF0240Bathyarchaeota archaeon@GN=CL673 archaeon 03556 RBG 13 52 0364512@GN=A3K78 01785 tr|A0A151BFN0|A0A151BFN0tr|A0A2H9HZY9|A0A2H9HZY9tr|O30187|O30187tr|A0A2E8EDZ9|A0A2E8EDZ9tr|A0A0M0BQR2|A0A0M0BQR2tr|A0A0M0BCP1|A0A0M0BCP1tr|A0A0M0BDW6|A0A0M0BDW6 ARCFU@Lar 9ARCH@Lar 9ARCH@Lar 9ARCH@LarN domain-containing N 9ARCH@Lar9ARCH@Lar domain-containing N9ARCH@Lar domain-containing N domain-containing NN Ndomain-containingdomain-containing protein@OS=Archaeoglobus domain-containing protein@OS=Candidatus protein@OS=Candidatus protein@OS=Candidatus protein@OS=miscellaneousprotein@OS=miscellaneous protein@OS=miscellaneous Bathyarchaeotafulgidus Bathyarchaeota strain Bathyarchaeota ATCC archaeon CrenarchaeotaCrenarchaeota archaeon Crenarchaeota 49558 B23@GN=AYL28archaeon@GN=CL673 /B24-2@GN=CP083 VC-16 group-15group group / DSM archaeon archaeon archaeon4304 002900 /05625 SMTZ1-55@GN=AC48004090JCM SMTZ1-55@GN=AC480 DG-45@GN=AC482 9628 / NBRC 100126@GN=AF 03015 06355 05520 0049 tr|A0A101WE06|A0A101WE06 9FIRM@Lartr|A0A1F8N913|A0A1F8N913tr|A0A2E8EGA7|A0A2E8EGA7tr|A0A1F5DJC3|A0A1F5DJC3tr|A0A0M0BJK0|A0A0M0BJK0 tr|A0A1F5DLU7|A0A1F5DLU7N domain-containingtr|A0A0M0BJ86|A0A0M0BJ86 protein@OS=Clostridia 9CHLR@Lar 9ARCH@Lar9ARCH@Lar 9ARCH@Lar 9ARCH@Lar N domain-containing N 9ARCH@LarN domain-containing domain-containing bacteriumN domain-containing NBRH proteindomain-containing c25@GN=APF77 protein@OS=Candidatus protein@OS=miscellaneous Fragment@OS=Chloroflexi protein@OS=Candidatus protein@OS=miscellaneous 00235 Bathyarchaeota Crenarchaeota bacteriumBathyarchaeota RBG archaeon@GN=CL673archaeon Crenarchaeota group 13archaeon 60 archaeon RBG13@GN=A2Y61 RBG 13 group 52SMTZ-80@GN=AC481 13 12@GN=A3K78 archaeon5203620 12@GN=A3K78 01620 SMTZ1-55@GN=AC480 02505 0097002935 03945 tr|A0A0S8CGC0|A0A0S8CGC0tr|E1QF10|E1QF10tr|A0A1M6EJE0|A0A1M6EJE0 DESB2@Lar 9CHLR@Lar N 9FIRM@Nickel-dependentdomain-containing N domain-containing protein@OS=Desulfarculus lactate protein@OS=Dehalococcoidia racemase@OS=Dethiosulfatibacter baarsii strain ATCC bacterium 33931 aminovorans SG8 / DSM 51 3@GN=AMJ70 2075 DSM / VKM 17477@GN=SAMN02745751 B-1802 04545 / 2st14@GN=Deba 01215 0774 tr|A0A1F8PK54|A0A1F8PK54tr|A0A133VFI6|A0A133VFI6 9CHLR@Lar 9EURY@Lar N domain-containing N domain-containing protein@OS=Chloroflexi protein@OS=candidate bacterium division RBG MSBL1 16 50 archaeon 9@GN=A2144 SCGC-AAA382A03@GN=AKJ49 11080 01285 tr|A0A256ZCH2|A0A256ZCH2tr|A0A0S8E5T4|A0A0S8E5T4tr|A0A0G1L988|A0A0G1L988tr|A0A0D2JKD8|A0A0D2JKD8 9ARCH@Lar 9BACT@Lar 9BACT@Uncharacterizedtr|A0A1F8Q5N3|A0A1F8Q5N3 9DELT@Lar Ntr|A0A1F8MJW0|A0A1F8MJW0tr|A0A1F8MJ21|A0A1F8MJ21 domain-containing N domain-containing N domain-containing protein@OS=Parcubacteria protein@OS=Candidatus protein@OS=Omnitrophica 9CHLR@Lar 9CHLR@Lar 9CHLR@Lar protein@OS=Dethiosulfatarculus N domain-containingN Ngroup Bathyarchaeotadomain-containing domain-containing WORbacterium 2 bacterium archaeon GW2011protein@OS=Chloroflexi protein sandiegensis@GN=X474protein@OS=Chloroflexi SM23 ex4484GWF2 Fragment@OS=Chloroflexi 29@GN=AMJ78 45 231@GN=B6U79 11@GN=UW91 bacterium bacterium 01675 00880 00185RBGC0024G0006 bacterium RBG 16 5613 11@GN=A2Z29 51RBG 52@GN=A2Y58 13 51 18@GN=A2Y89 09780 04750 03690 tr|A0A151BL93|A0A151BL93tr|C0D606|C0D606tr|A0A0F0CJQ1|A0A0F0CJQ1 9ARCH@Lar 9FIRM@Lar N domain-containing 9CLOT@Lar N domain-containingtr|A0A1F8M9C6|A0A1F8M9C6tr|V4IYH9|V4IYH9 Ntr|A0A1F8QSC5|A0A1F8QSC5 domain-containing protein@OS=Candidatustr|R9M1S9|R9M1S9 protein@OS= 9GAMM@Lar protein@OS=Clostridium asparagiforme Bathyarchaeota 9FIRM@Lar9CHLR@Lar N9CHLR@Lar domain-containing DSM N N domain-containing15981@GN=CLOSTASPARarchaeon domain-containing Nsp. domain-containing FS41@GN=CLFS41 protein@OS=unculturedB26-1@GN=AYL31 protein@OS=Oscillibacter protein protein 08820Fragment@OS=Chloroflexi 04702 006280 Fragment@OS=Chloroflexi Thiohalocapsa sp. 1-3@GN=C816sp. PB-PSB1@GN=N838 bacterium bacterium RBG02747 RBG 13 5116 08605 18@GN=A2Y8957 8@GN=A2147 02415 10635 tr|A0A256YYY5|A0A256YYY5tr|A0A151BN17|A0A151BN17tr|A0A151BAE1|A0A151BAE1tr|A0A1F5DD61|A0A1F5DD61tr|A0A0M0BNM6|A0A0M0BNM6 9ARCH@Lar9ARCH@Lartr|D8FG49|D8FG49 N9ARCH@LarN domain-containingdomain-containing 9ARCH@Lar 9ARCH@Lar 9DELT@Lar N domain-containing N domain-containing N Nprotein@OS=Candidatusprotein@OS=Candidatus domain-containingdomain-containingtr|R5AV40|R5AV40tr|A0A1Y4WD98|A0A1Y4WD98tr|G5IKI0|G5IKI0 protein@OS=Candidatus protein@OS=Candidatus protein@OS=miscellaneous protein@OS=delta 9CLOT@LarBathyarchaeota Bathyarchaeota9FIRM@Lar NN9FIRM@Lar Bathyarchaeota proteobacterium domain-containingarchaeondomain-containingarchaeon Bathyarchaeota Crenarchaeota ex4484B26-2@GN=AYL32 N domain-containing archaeon NaphS2@GN=NPH 40@GN=B6U84 archaeonprotein@OS=Hungatellaprotein@OS=Firmicutes group B23@GN=AYL28 RBG archaeon006240 protein@OS=Flavonifractor 0193013 462238 SMTZ1-55@GN=AC480 9@GN=A3K80 005780 bacteriumhathewayi CAG WAL-18680@GN=HMPREF947302725 sp. An10@GN=B5E4201685 14575 04008 tr|A0A1M6E4M3|A0A1M6E4M3tr|A0A117SFE6|A0A117SFE6tr|A0A1F5DFQ3|A0A1F5DFQ3tr|I2F8N2|I2F8N2tr|A0A1M7XZ10|A0A1M7XZ10 9FIRM@Nickel-dependent 9FIRM@Lar9BACT@Lar 9ARCH@Lar N N domain-containing domain-containingN domain-containing 9DELT@Nickel-dependent lactatetr|B0PDP6|B0PDP6 racemase@OS=Dethiosulfatibacter protein@OS=Clostridia protein@OS=Mesotoga protein@OS=Candidatus 9FIRM@Lar lactate racemase@OS=Desulfopila bacterium prima N domain-containingBathyarchaeota MesG1.Ag.4.2@GN=Theba BRHaminovorans c25@GN=APF77 archaeon DSMprotein@OS=Anaerotruncus aestuarii 17477@GN=SAMN02745751 RBG 18515 DSM 268613 38 18488@GN=SAMN02745220 9@GN=A3K80 colihominis 05930 01064 DSM 17241@GN=ANACOL 00653 03200 tr|A0A0M2TZB8|A0A0M2TZB8tr|A0A1W1W024|A0A1W1W024tr|A0A151BAC9|A0A151BAC9tr|I4BZ54|I4BZ54tr|A0A133U6S1|A0A133U6S1tr|A0A0F0C864|A0A0F0C864 9FIRM@Lar ACEMN@Lar 9THEO@Nickel-dependentBATXB@Lartr|A0A0D2HRR6|A0A0D2HRR6 N domain-containing N N 9EURY@Lardomain-containing domain-containing 9CLOT@Lar lactateN protein@OS=Clostridiales N domain-containing domain-containing protein@OS=Acetomicrobium protein@OS=Bathyarchaeotaracemase@OS=Thermanaeromonas 9DELT@Lar protein@OS=candidate Nprotein@OS=Clostridium domain-containing bacterium mobilearchaeonPH28 bin88@GN=SY88 strain toyohensisprotein@OS=Dethiosulfatarculus division strain sp.ATCC B24@GN=AYL29FS41@GN=CLFS41 MSBL1 ToBE@GN=SAMN00808754 BAA-54 20550 archaeon / DSM 010730 13181SCGC-AAA259A05@GN=AKJ57 54890 sandiegensis@GN=X474/ JCM 2665 12221 / NGA@GN=Anamo 14840 04730 1978 tr|A0A1Y1S3M0|A0A1Y1S3M0tr|A0A259UTX6|A0A259UTX6tr|A0A1G5RW61|A0A1G5RW61tr|A0A1H0UD77|A0A1H0UD77 9SPIO@Lar N 9FIRM@Lardomain-containing 9DELT@Nickel-dependent 9FIRM@Nickel-dependent N domain-containing protein@OS=Marispirochaeta lactatelactate protein@OS=Sporomusa racemase@OS=Desulforhopalusracemase@OS=Acidaminobacter aestuarii@GN=B4O97 acidovorans 02840singaporensis@GN=SAMN05660330 hydrogenoformans DSM 3132@GN=SPACI DSM 2784@GN=SAMN03080599 16930 03487 01116 tr|A0A259UMU7|A0A259UMU7tr|I9AWZ8|I9AWZ8tr|Q2RKJ2|Q2RKJ2tr|A0A0C7NM02|A0A0C7NM02tr|A0A101VVT1|A0A101VVT1tr|A0A0D2JIZ6|A0A0D2JIZ6tr|R5KAA8|R5KAA8tr|A0A1U7MH02|A0A1U7MH02tr|A0A124INS6|A0A124INS6tr|A0A099RM15|A0A099RM15tr|G9PVD6|G9PVD6 9FIRM@Lar MOOTA@Lartr|A0A1M5AB23|A0A1M5AB23 9CLOT@Lar 9FIRM@Lar9DELT@Lar N9FIRM@Lar 9THEO@Lar tr|A0A010YE59|A0A010YE59 domain-containingN 9BACT@Lar domain-containing 9FIRM@LarN NN 9FIRM@Lar N domain-containing9CLOT@Lar domain-containing domain-containingN domain-containing domain-containing N domain-containing protein@OS=Pelosinus protein@OS=Moorella9CLOT@Nickel-dependentN Ndomain-containing N domain-containing domain-containing protein@OS=Sporomusa protein@OS=Clostridiumprotein@OS=Dethiosulfatarculus9BACT@Lar protein@OS=Gracilibacter protein@OS=Moorella protein@OS=Synergistes fermentans protein@OS=Clostridia thermoacetica Nprotein@OS=Sporomusa protein@OS=Clostridium domain-containing lactate B4@GN=FB4 silvacetica glycerini@GN=1447 sp. racemase@OS=Lactonifactor sp.strain CAG BRH sp.sandiegensis@GN=X474 ATCC tr|G5IKH9|G5IKH9DSM protein@OS=Cloacibacillusbacteriumc7a@GN=APF84 34156 1 syn1@GN=HMPREF100610669@GN=SPSILsphaeroides39073 sp. HMP27@GN=DP68 BRH/ JCM c25@GN=APF77 DSM 9320@GN=Moth 151559CLOT@Lar longoviformis 032202875@GN=SPSPH 21200 evryensis 18145 01356 N 204900729domain-containing DSM DSM 17459@GN=SAMN02745158 02820 19522@GN=Cloev protein@OS=Hungatella 0621 03105 hathewayi WAL-18680@GN=HMPREF9473 04007 tr|A1HLP3|A1HLP3tr|A0A154BM27|A0A154BM27tr|B1L709|B1L709tr|D5EGU8|D5EGU8tr|A0A1Z5HRQ4|A0A1Z5HRQ4tr|A0A1M6F0N3|A0A1M6F0N3 9FIRM@Lartr|A0A1Y4GEK8|A0A1Y4GEK8 KORCO@Lar AMICL@Lar ANASB@LarN domain-containing tr|A0A073IS40|A0A073IS40N 9THEO@Lar domain-containingN domain-containing N 9FIRM@Nickel-dependentdomain-containing 9BACT@Larprotein@OS=Thermosinus N domain-containing protein@OS=Korarchaeum protein@OS=Aminobacterium protein@OS=AnaerosporomusaN 9BACT@Lardomain-containing lactate protein@OS=Calderihabitans carboxydivorans racemase@OS=DethiosulfatibacterN domain-containing protein@OS=Cloacibacilluscryptofilum colombiense Nor1@GN=TcarDRAFT subterranea@GN=AXX12 strain protein@OS=Synergistes maritimus@GN=KKC1OPF8@GN=Kcr strain DSM sp. aminovorans12261 An23@GN=B5F392440 1492 15750 / ALA-1@GN=Amico 11100 jonesii@GN=EH55 DSM 17477@GN=SAMN02745751 06015 1664 05105 01308 tr|A0A1M5VZN5|A0A1M5VZN5tr|A0A1W1VWH0|A0A1W1VWH0tr|A0A0C7NAQ8|A0A0C7NAQ8tr|A0A073IPI2|A0A073IPI2tr|G9PVG4|G9PVG4tr|A0A010YTT7|A0A010YTT7 9DELT@Nickel-dependent 9THEO@Lar9THEO@Nickel-dependent 9BACT@Lar 9BACT@Lar 9BACT@Lar N domain-containing N domain-containing lactateN domain-containing N lactatedomain-containing racemase@OS=Desulfofustis protein@OS=Moorellaracemase@OS=Thermanaeromonas protein@OS=Synergistes protein@OS=Synergistes protein@OS=Cloacibacillus glycerini@GN=3466 glycolicus sp. 3 DSM 1jonesii@GN=EH55 toyohensissyn1@GN=HMPREF1006 9705@GN=SAMN02745124 evryensis ToBE@GN=SAMN00808754 DSM 04585 19522@GN=Cloev 01384 01984 0711 1792 tr|A0A0P6XCZ6|A0A0P6XCZ6 9CHLR@Lar N domain-containing protein@OS=Ornatilinea apprima@GN=ADN00 01695 tr|E8N2M9|E8N2M9tr|A0A0M8JQJ0|A0A0M8JQJ0 ANATU@Lartr|V4IJ69|V4IJ69tr|A0A154BMA6|A0A154BMA6tr|I4BYQ5|I4BYQ5 9CHLR@Uncharacterized N domain-containing 9DELT@Lar ACEMN@Lar N domain-containing protein@OS=Anaerolinea conservedANASB@Lar N domain-containing protein@OS=Levilinea N protein@OS=uncultureddomain-containing thermophila protein@OS=Acetomicrobium saccharolytica@GN=ADN01 strainprotein@OS=Anaerosporomusa DesulfofustisDSM 14523 / sp.JCM mobilePB-SRB1@GN=N839 11388 04245 strain / NBRC subterranea@GN=AXX12 ATCC 100420 BAA-54 00825 / UNI-1@GN=ANT / DSM 13181 13115 / 08010JCM 12221 / NGA@GN=Anamo 1826 tr|A0A154BLH9|A0A154BLH9 ANASB@Lar N domain-containing protein@OS=Anaerosporomusa subterranea@GN=AXX12 16540 tr|A0A0S7BAX0|A0A0S7BAX0 9CHLR@Uncharacterized conserved protein@OS=Longilinea arvoryzae@GN=LARV 00049 tr|A8ZW93|A8ZW93 DESOH@Lar N domain-containing protein@OS=Desulfococcus oleovorans strain DSM 6200 / Hxd3@GN=Dole 2523 tr|I4C9R8|I4C9R8 DESTA@Lar N domain-containing protein@OS=Desulfomonile tiedjei strain ATCC 49306 / DSM 6799 / DCB-1@GN=Desti 3663 tr|B4D7H2|B4D7H2 9BACT@Lar N domain-containing protein@OS=Chthoniobacter flavus Ellin428@GN=CfE428DRAFT 4887 tr|A0A1G3QBK9|A0A1G3QBK9 9SPIR@Lar N domain-containing protein@OS=Spirochaetes bacterium RBG 13 51 14@GN=A2176 08755 tr|L0D767|L0D767tr|A0A1U7GL04|A0A1U7GL04tr|A0A1U7CRC1|A0A1U7CRC1 SINAD@Lar N9BACT@Lar 9BACT@Lardomain-containing N Ndomain-containing domain-containing protein@OS=Singulisphaera protein@OS=Planctomycetales protein@OS=Paludisphaera acidiphila strain borealis@GN=BSF38 bacteriumATCC BAA-1392 71-10@GN=BGO49 / DSM 03005 18658 03670/ VKM B-2454 / MOB10@GN=Sinac 0264 tr|E8R4L0|E8R4L0tr|A0A142Y9P9|A0A142Y9P9 ISOPI@Lar N9PLAN@Lar domain-containing N domain-containing protein@OS=Isosphaera protein@OS=Planctomyces pallida strain ATCC sp. SH-PL62@GN=VT8543644 / DSM 9630 / IS1B@GN=Isop 00735 0004 tr|C0QLL0|C0QLL0tr|A0A0S8HCA6|A0A0S8HCA6 DESAH@Lar N domain-containing 9BACT@Lar protein@OS=DesulfobacteriumN domain-containing protein@OS=Phycisphaerae autotrophicum strain bacterium ATCC 43914 SM23 / DSM 33@GN=AMJ81 3382 / HRM2@GN=HRM2 09005 32350

tr|D4ZPM5|D4ZPM5 ARTPN@Lar N domain-containing protein@OS=Arthrospira platensis strain NIES-39 / IAM M-135@GN=NIES39 D07030 tr|A0A1Q8ZCG4|A0A1Q8ZCG4 9CYAN@Lar N domain-containing protein@OS=Leptolyngbya sp. 'hensonii'@GN=BST81 13050 tr|A0A0F5YJX1|A0A0F5YJX1tr|A0A1G1YSU3|A0A1G1YSU3tr|A0YJA3|A0YJA3 LYNSP@Lar 9CYAN@Lar 9BACT@Lar N domain-containing N Ndomain-containing domain-containing protein@OS=Lyngbya protein@OS=Limnoraphis protein@OS=Candidatus sp. strain PCC robusta Buchananbacteria8106@GN=L8106 CS-951@GN=WN50 bacterium02277 05535 RIFCSPLOWO2 01 FULL 40 23b@GN=A2912 00780

tr|A0A2A2RFV0|A0A2A2RFV0tr|A0A2A2RM53|A0A2A2RM53tr|A0A2G4I8G3|A0A2G4I8G3 9BACT@-binding 9BACT@-binding 9BACT@-binding protein@OS=Pedosphaera protein@OS=Pedosphaera protein@OS=Pedosphaera sp. sp.Tous-C6FEB@GN=B9S33 Tous-C6FEB@GN=B9S33 sp.@GN=CK546 15725 06040 12305 tr|A0A0B6X2S1|A0A0B6X2S1 9BACT@Lar N domain-containing protein@OS=Pyrinomonas methylaliphatogenes@GN=PYK22 02888 tr|D2R2M0|D2R2M0tr|A0A286RA47|A0A286RA47tr|A4A1T3|A4A1T3 PIRSD@Lar N domain-containing 9BACT@Lar 9BACT@Iron-sulfur N domain-containing protein@OS=Pirellula cluster binding protein@OS=Blastopirellula staleyi protein@OS=Thermogutta strain ATCC 27377 marina / DSM terrifontis@GN=THTE DSM 6068 3645@GN=DSM3645 / ICPB 4128@GN=Psta 0229 29476 2188 tr|A0A1Q7ZPF8|A0A1Q7ZPF8 9CYAN@Lar N domain-containing protein@OS=Cyanobacteria bacterium 13 1 40CM 2 61 4@GN=AUI36 04830 tr|A0A1I3JAP3|A0A1I3JAP3tr|A0A142X7A2|A0A142X7A2tr|A0A177RCS6|A0A177RCS6 9PLAN@Lar N domain-containing 9PLAN@Lar 9PLAN@-binding N protein@OS=Planctomicrobium domain-containing protein@OS=Planctomyces protein@OS=Planctomyces piriforme@GN=SAMN05421753 sp. SCGC AG-212-M04@GN=AYO47 sp. SH-PL14@GN=VT03 110115 07860 30635 tr|A0A0S8KED3|A0A0S8KED3tr|A0A1V0DCV9|A0A1V0DCV9tr|A0A1G0SFF8|A0A1G0SFF8tr|A0A1F5C5B5|A0A1F5C5B5 9CHLR@Lar9BACT@Lar 9BACT@Lar NN domain-containingdomain-containing 9BACT@Lar N domain-containing N protein@OS=Anaerolineaeprotein@OS=Rhodothermaceaedomain-containing protein@OS=Ignavibacteria protein@OS=Candidatus bacterium bacterium SM23 bacterium RA@GN=AWN76 84@GN=AMJ93 Atribacteria RIFCSPLOWO2 12455005355bacterium 12 RBG FULL 16 56 35 21@GN=A3G43 8@GN=A2V94 0202500070 tr|D5SSA2|D5SSA2 PLAL2@Iron-sulfurtr|A0A1P8WGF2|A0A1P8WGF2 cluster bindingtr|A6C1G6|A6C1G6 protein@OS=Planctopirus 9PLAN@Lar 9PLAN@Lar N domain-containing limnophila N domain-containing strain ATCC protein@OS=Fuerstia protein@OS=Gimesia 43296 / DSM 3776 marisgermanicae@GN=Fuma / IFAMmaris 1008DSM /8797@GN=PM8797T 290@GN=Plim 02728 3004 12593 tr|A0A1W9PER3|A0A1W9PER3tr|A0A0S8H4K2|A0A0S8H4K2 9BACT@Lar 9BACT@Lar N domain-containing N domain-containing protein@OS=candidate protein@OS=Phycisphaerae division KSB1 bacterium bacterium SM23 4484 33@GN=AMJ81 219@GN=B5M50 12970 06690 tr|M5RNX2|M5RNX2 9BACT@Lar N domain-containing protein@OS=Rhodopirellula maiorica SM1@GN=RMSM 02182 tr|D6TPR9|D6TPR9tr|A0A1F8PAZ5|A0A1F8PAZ5tr|A0A1G1A0G9|A0A1G1A0G9tr|A0A2A5E787|A0A2A5E787 9CHLR@Lar 9CHLR@Lar N 9BACT@Lar 9BACT@Lardomain-containing N domain-containing N N domain-containing domain-containing protein@OS=Ktedonobacter protein@OS=Chloroflexi protein@OS=Candidatus protein@OS=Lentisphaerae racemifer bacterium DSM Hydrogenedentes 44963@GN=Krac bacterium RBG 16 48 RIFOXYA12 8@GN=A2Z14 bacterium@GN=COA73 8838 FULL 18470 48 11@GN=A2283 04970 11860 tr|A0A1G3QI69|A0A1G3QI69tr|A0A1E3XFL5|A0A1E3XFL5 9SPIR@Lar 9BACT@Lar N domain-containing N domain-containing protein@OS=Spirochaetes protein@OS=Candidatus bacterium Scalindua RBG 13 rubra@GN=SCARUB51 14@GN=A2176 04200 00426 tr|A0A0P0SHJ7|A0A0P0SHJ7tr|A0A1H7QRL0|A0A1H7QRL0tr|A0A1H1W7G6|A0A1H1W7G6tr|A0A1J5A4A8|A0A1J5A4A8tr|A0A1Y6K5G5|A0A1Y6K5G5tr|A0A1Q8BN18|A0A1Q8BN18tr|A0A146GE36|A0A146GE36tr|A0A177RDV5|A0A177RDV5tr|B4CVV3|B4CVV3tr|A0A1I3RPF9|A0A1I3RPF9 9PSEU@Lar STRJI@Nickel-dependent 9ACTN@Nickel-dependent 9BACT@Lar 9CHLR@Lar 9CHLR@Lar 9CYAN@LarN domain-containing 9PLAN@Nickel-dependentTERSA@Nickel-dependent 9PLAN@Lar N N domain-containing Ndomain-containing lactateN domain-containing domain-containinglactate racemase@OS=StreptacidiphilusNprotein@OS=Pseudonocardia domain-containingracemase@OS=Actinopolymorpha protein@OS=Chthoniobacterprotein@OS=Anaerolineae protein@OS=Brevefilum lactatelactate protein@OS=Cyanobacteria racemase@OS=Planctomicrobiumracemase@OS=Terrimicrobium protein@OS=Planctomyces sp. jiangxiensis@GN=SAMN05414137 EC080619-01@GN=AD017 singaporensis@GN=SAMN04489717 fermentans@GN=CFX1CAMbacterium flavus bacterium Ellin428@GN=CfE428DRAFT CG2 sp. 3013 sacchariphilum@GN=TSACCSCGC 641 piriforme@GN=SAMN05421753 2699520CM 16@GN=AUK03 AG-212-M04@GN=AYO47 109167 4 076461 6@GN=AUG75 4372 14420 0790 31308295 0169012166 tr|A0A0M2U5X5|A0A0M2U5X5 9FIRM@Lar N domain-containing protein@OS=Clostridiales bacterium PH28 bin88@GN=SY88 15755 tr|A0A238XDX7|A0A238XDX7tr|A0A1T3NLU3|A0A1T3NLU3tr|A0A0A0B5F4|A0A0A0B5F4tr|A0A1I5H3E5|A0A1I5H3E5tr|B9XR65|B9XR65tr|A0A1H1P5L7|A0A1H1P5L7tr|D5SNL6|D5SNL6 9ACTN@Nickel-dependent tr|A8F5F5|A8F5F59PSEU@Nickel-dependent9ACTN@Lar9CELL@Lar PEDPL@Lar PLAL2@Lar N domain-containing 9BACT@Nickel-dependent NPSELT@Lar Ndomain-containing lactatedomain-containing lactate racemase@OS=Blastococcus protein@OS=Embleya protein@OS=Cellulomonasracemase@OS=Pseudonocardia N domain-containing protein@OS=Pedosphaera protein@OS=Planctopirus lactate scabrispora@GN=B4N89racemase@OS=Opitutus protein@OS=Pseudothermotoga sp. cellasea DSM ammonioxydans@GN=SAMN05216207 44272@GN=SAMN06272737DSM parvula 20118@GN=Q760limnophila 42645 strain sp. strainGAS368@GN=SAMN05444173 Ellin514@GN=Cflav ATCC04325 lettingae 11339 43296 strain105613 / DSM PD0713 ATCC 3776 BAA-301 /1780 IFAM 1008 / DSM / 290@GN=Plim 14385 / NBRC 1079222304 / TMO@GN=Tlet 0823 tr|A0A0T6A791|A0A0T6A791tr|A0A177QZM6|A0A177QZM6 9BACT@Iron-sulfur cluster 9PLAN@-binding binding protein@OS=candidate protein@OS=Planctomycetaceae division NC10 bacterium CSP1-5@GN=XU15SCGC AG-212-F19@GN=AYO44 C0002G0089 04725 tr|A0A1H9THX2|A0A1H9THX2tr|A0A021VUT5|A0A021VUT5tr|A0A0C1QMV7|A0A0C1QMV7tr|D7CTD9|D7CTD9 9MICO@Nickel-dependent9CELL@Lar TRURR@Lar 9CYAN@Lar N domain-containing N domain-containing Nlactate domain-containing racemase@OS=Phycicoccus protein@OS=Actinotalea protein@OS=Truepera protein@OS=Tolypothrix ferrariae cremeus@GN=SAMN05216199 CF5-4@GN=N866 radiovictrix bouteillei strain VB521301@GN=DA73 00730 DSM 1620 17093 / CIP 0236915108686 / LMG 22925 / RQ-24@GN=Trad 0660 tr|F0SSI8|F0SSI8 RUBBR@Iron-sulfur cluster binding protein@OS=Rubinisphaeratr|A0A2A4M9X2|A0A2A4M9X2 brasiliensis strain ATCC 9BACT@Lar 49424 / DSM N domain-containing5305 / JCM 21570 protein@OS=Verrucomicrobiales/ NBRC 103401 / IFAM 1448@GN=Plabr bacterium@GN=COC21 2704 00530 tr|A0A1Q9TBX5|A0A1Q9TBX5tr|A0A235HXC6|A0A235HXC6tr|A0A1Q3SHU2|A0A1Q3SHU2tr|A0A235IJU5|A0A235IJU5tr|A0A2A2RYE9|A0A2A2RYE9tr|A0A2G4I5E5|A0A2G4I5E5 9ACTN@Lar 9NOSO@Lar 9NOSO@Lar 9CHLR@Lar N domain-containing 9BACT@Lar 9BACT@Lar N domain-containingN N domain-containing domain-containing N protein@OS=Actinomadura Ndomain-containing domain-containing protein@OS=Nostoc protein@OS=Nostoc protein@OS=Chloroflexi protein@OS=Pedosphaera protein@OS=Pedosphaera sp. sp.CNU-125@GN=BJF79 sp. 'Peltigera 'Peltigera bacterium membranacea membranacea 54-19@GN=BGO39 sp.@GN=CK546 15705sp. Tous-C6FEB@GN=B9S33 cyanobiont' cyanobiont' 3278508190 213@GN=CDG77 210A@GN=CDG76 02310 06695 33355 tr|A0A1F8QXB0|A0A1F8QXB0tr|A0A0M2U1I1|A0A0M2U1I1 9CHLR@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Chloroflexi protein@OS=Clostridiales bacterium RBG bacterium 16 57 PH288@GN=A2147 bin88@GN=SY88 07415 15260 tr|A0A1H1XGZ5|A0A1H1XGZ5tr|A8LED2|A8LED2tr|A0A1Z4G037|A0A1Z4G037tr|B2J4G4|B2J4G4tr|A0A252E3F8|A0A252E3F8tr|A0A0D6KS87|A0A0D6KS87tr|A5UUY6|A5UUY6tr|A0A1F8SWP6|A0A1F8SWP6tr|A0A1F8LXG6|A0A1F8LXG6tr|A0A1F8SJN9|A0A1F8SJN9tr|F0SL07|F0SL07 FRASN@Lar NOSP7@Lar ROSS1@Lar 9ACTN@Nickel-dependent tr|Q9WYS3|Q9WYS3N domain-containing 9CYAN@Lar9NOSO@Lar 9CYAN@LarRUBBR@Lar N 9CHLR@Lar domain-containing9CHLR@Lar N9CHLR@Lar domain-containing NN N domain-containingprotein@OS=Frankiadomain-containing N domain-containingN N THEMA@Larlactatedomain-containing Ndomain-containing domain-containing domain-containing protein@OS=Nostoc racemase@OS=Actinoplanes protein@OS=Roseiflexus protein@OS=CalothrixNprotein@OS=Nostoc protein@OS=Tolypothrixsp.domain-containing protein@OS=Chloroflexi protein@OS=Rubinisphaerastrainprotein@OS=Chloroflexi protein@OS=Chloroflexi punctiforme EAN1pec@GN=Franean1 sp. derwentensis@GN=SAMN04489716 sp. strainstrain sp.protein@OS=Thermotoga T09@GN=BV372 NIES-2098@GN=NIES2098 sp. ATCCRS-1@GN=RoseRS bacteriumPCC bacterium bacterium 29133 7601@GN=FDUTEX481 brasiliensis3196 RBG RBG/ RBG14155PCC 19FT 13 19FT 73102@GN=Npun 2056strain 48 COMBOmaritima 10@GN=A2Y88 COMBO40520 2463ATCC 0704049 strain 4942447 13@GN=A2032 9@GN=A2029 F5335 ATCC /02345 DSM 43589 5305 06385 17370 / /MSB8 JCM 21570 / DSM / 3109NBRC / JCM103401 10099@GN=TM / IFAM 1448@GN=Plabr 0442 2258 tr|A0A1J5CEC3|A0A1J5CEC3 9BACT@Lar N domain-containing protein@OS=bacterium CG2 30 54 10@GN=AUK22 11680 tr|A0A1H9G2N7|A0A1H9G2N7tr|A0A1S1RLX3|A0A1S1RLX3tr|A0A1S1QX33|A0A1S1QX33tr|I4EW68|I4EW68tr|A0A117MMC7|A0A117MMC7tr|A0A1H1VGW5|A0A1H1VGW5tr|A0A1Z4L967|A0A1Z4L967tr|A0A1U7I2F4|A0A1U7I2F4tr|A0A2C6VW57|A0A2C6VW57tr|A0A1F8NIX9|A0A1F8NIX9tr|A0A1M3K9X4|A0A1M3K9X4tr|A0A136NVU5|A0A136NVU5 9ACTN@Lar 9ACTN@Nickel-dependent 9ACTN@Lar 9ACTN@Lar N 9ACTN@Lar domain-containing 9ACTN@Nickel-dependent 9NOSO@LarNOSLI@Lar 9CHLR@Lar NNOSLI@LarN domain-containing domain-containing 9CHLR@LarN domain-containing 9CHLR@Uncharacterized lactateprotein@OS=ModestobacterN N domain-containing domain-containingN N domain-containing racemase@OS=Friedmannielladomain-containing N domain-containing protein@OS=Frankiaprotein@OS=Frankia lactate protein@OS=Actinoplanes racemase@OS=Microlunatus protein@OS=Nostocprotein@OS=Nostoc protein@OS=Nostoc protein@OS=Chloroflexiprotein@OS=Chloroflexi marinus@GN=MODMU protein@OS=Chloroflexi sp.sp. BMG5.36@GN=BCD48 Cc1.17@GN=CC117flava@GN=SAMN05421756 awajinensis linckiacalcicola linckia soli@GN=SAMN04489812 NIES-25@GN=NIES25 2196 subsp.bacterium z16@GN=VF13FACHB-389@GN=FACHB389bacterium 15880bacterium 21305 mycoplanecinus@GN=ADL15 103474 RBG OLB13@GN=UZ13 44-23@GN=BGO78 16 32150 47 41910 49@GN=A2Y53 3195 24270 02660 4098003175 05900 tr|A0A1F4QBB5|A0A1F4QBB5tr|A0A1J5HYK4|A0A1J5HYK4 9BACT@Lar N domain-containing 9DELT@Lar protein@OS=candidate N domain-containing division protein@OS=Syntrophaceae NC10 bacterium RIFCSPLOWO2 bacterium 02CG2 FULL 30 58 66 14@GN=AUK26 22@GN=A3H39 10205 14300 tr|A0A285KCQ2|A0A285KCQ2tr|A0A1M7PC85|A0A1M7PC85tr|G8SHM7|G8SHM7tr|A0A1M7YEU5|A0A1M7YEU5tr|A0A0P6Y9F8|A0A0P6Y9F8tr|A0A143PJ76|A0A143PJ76 tr|A6CCB6|A6CCB6ACTS5@Lar 9ACTN@Nickel-dependent9ACTN@Nickel-dependent N domain-containing 9PLAN@Lar 9CHLR@Uncharacterized9DELT@Nickel-dependent 9BACT@Lar protein@OS=Actinoplanes lactate N domain-containing racemase@OS=Actinoplanesracemase@OS=Cryptosporangium N domain-containing protein@OS=Ornatilinea lactate sp. protein@OS=Gimesia strain racemase@OS=Desulfopila protein@OS=Luteitalea ATCC atraurantiacus@GN=SAMN05421748 31044 aurantiacum@GN=SAMN05443668 / apprima@GN=ADN00CBS maris 674.73 DSM pratensis@GN=LuPra aestuarii / SE50/110@GN=ACPL 8797@GN=PM8797T DSM 06660 134112 18488@GN=SAMN02745220 103195 01821 3390 31990 03881 tr|A0A1F5C5F6|A0A1F5C5F6 9BACT@Lartr|D8F1U0|D8F1U0 N domain-containing 9DELT@Lar protein@OS=Candidatus N domain-containing Aminicenantes protein@OS=delta bacterium proteobacterium RBG 19FT COMBO NaphS2@GN=NPH 58 17@GN=A2V45 2396 08535 tr|E3J4Z7|E3J4Z7tr|A0A1J5HUG3|A0A1J5HUG3 FRAIE@Lartr|A0A1P8WDH6|A0A1P8WDH6 N domain-containing protein@OS=Frankia9DELT@Lar 9PLAN@Lar N domain-containing inefficax N domain-containing strain DSM protein@OS=Syntrophaceae 45817 / protein@OS=FuerstiaCECT 9037 / EuI1c@GN=FraEuI1c bacterium marisgermanicae@GN=Fuma CG2 1381 30 58 14@GN=AUK26 01714 12590 tr|F5XM14|F5XM14tr|A0A1H1SEV8|A0A1H1SEV8tr|D2PP82|D2PP82 MICPN@Lartr|A0A0S7BTQ6|A0A0S7BTQ6tr|A0A1F8L7F7|A0A1F8L7F7 KRIFD@Lar 9ACTN@Nickel-dependent N domain-containing N domain-containing protein@OS=Microlunatus 9CHLR@Nickel-dependent9CHLR@Uncharacterized lactateprotein@OS=Kribbella racemase@OS=Friedmanniella phosphovorus flavida protein@OS=Chloroflexi lactatestrain strain luteola@GN=SAMN04488543 DSM racemase@OS=Flexilinea ATCC 17836 700054 / JCM / 10339DSM bacterium 10555 / NBRC 1777 / GWB2 flocculi@GN=ATC1JCM 14399@GN=Kfla 9379 54 / 36@GN=A2X24NBRC 101784 5672 131214 / NCIMB 12200 13414 / VKM Ac-1990 / NM-1@GN=MLP 08790 tr|A0A1F4QBB7|A0A1F4QBB7tr|S0G871|S0G871 9BACT@Lar 9DELT@Lar N domain-containing N domain-containing protein@OS=candidate protein@OS=Desulfotignum division phosphitoxidansNC10 bacterium DSMRIFCSPLOWO2 13687@GN=Dpo 02 FULL 1c06670 66 22@GN=A3H39 14275 tr|K6VM93|K6VM93tr|I4EYL3|I4EYL3tr|R4LX98|R4LX98 9MICO@Lar9ACTN@Lartr|V4JGD9|V4JGD9 9ACTN@Lar N N domain-containing domain-containingN domain-containing 9DELT@Lar protein@OS=Kineosphaera protein@OS=Modestobacter protein@OS=Actinoplanes N domain-containing limosa protein@OS=uncultured marinus@GN=MODMUsp. NBRC N902-109@GN=L083 100340@GN=KILIM 3050 6350Desulfofustis 064 00060 sp. PB-SRB1@GN=N839 10420 tr|U5VXZ4|U5VXZ4tr|W9GGB4|W9GGB4 9ACTN@Lar 9MICO@Lar N Ndomain-containing domain-containing protein@OS=Actinoplanes protein@OS=Intrasporangium friuliensis chromatireducens DSM 7358@GN=AFR Q5-1@GN=N864 16820 07485 tr|A0A2A9EQ35|A0A2A9EQ35tr|A0A1H0N5S3|A0A1H0N5S3tr|A0A285VLZ9|A0A285VLZ9 9MICO@Nickel-dependent9ACTN@Lar9MICO@Nickel-dependent N domain-containing lactate lactate racemase@OS=Georgenia protein@OS=Nakamurellaracemase@OS=Ornithinimicrobium soli@GN=ATJ97panacisegetis@GN=SAMN04515671 pekingense@GN=SAMN05421879 3775 2218 104159 tr|U2YH50|U2YH50tr|V4HJ79|V4HJ79tr|V4XVY9|V4XVY9 9EURY@Iron-sulfur 9EURY@Lar 9ARCH@Lar N domain-containing cluster N domain-containing binding protein@OS=Halarchaeum protein@OS=Candidatus protein@OS=uncultured acidiphilumHalobonum archaeon MH1-52-1@GN=MBEHAL tyrrellensis A07HR67@GN=A07HR67 G22@GN=K933 2516 11711 00842 tr|A0A1B1NGQ5|A0A1B1NGQ5tr|A0A1H7CRN5|A0A1H7CRN5 9MICO@Putative D-mannonate 9DEIO@Nickel-dependent dehydrogenase@OS=Serinicoccus lactate sp. racemase@OS=Deinococcus JLT9@GN=SGUI 3207 reticulitermitis@GN=SAMN04488058 1316 tr|A0A1G6GY58|A0A1G6GY58tr|E6S738|E6S738 INTC7@Lar 9ACTN@Nickel-dependent N domain-containing protein@OS=Intrasporangium lactate racemase@OS=Raineyella calvum antarctica@GN=GA0111570 strain ATCC 23552 / DSM 105144 43043 / JCM 3097 / NBRC 12989 / 7 KIP@GN=Intca 2465 tr|A0A1W1VVK1|A0A1W1VVK1 9THEO@Nickel-dependent lactate racemase@OS=Thermanaeromonas toyohensis ToBE@GN=SAMN00808754 1799 tr|A0A0A0JUF6|A0A0A0JUF6 9MICO@Lar N domain-containing protein@OS=Knoellia aerolata DSM 18566@GN=N801 12150 tr|U1PLS4|U1PLS4 9EURY@Uncharacterizedtr|A0A1I0MF72|A0A1I0MF72tr|R4W7W0|R4W7W0tr|A0A161XDM6|A0A161XDM6 conserved protein 9EURY@Lar 9EURY@Lar DUF2088@OS=Haloquadratum N domain-containing 9EURY@LarN domain-containing N domain-containing protein@OS=Halopiger walsbyiprotein@OS=Salinarchaeum J07HQW1@GN=J07HQW1 protein@OS=Haladaptatus salifodinae@GN=SAMN05216285 sp. Harcht-Bsk1@GN=L593 03245 sp. R4@GN=A4G99 0835 06480 06045 tr|A0A0C7NAR2|A0A0C7NAR2 9THEO@Lar N domain-containing protein@OS=Moorella glycerini@GN=3476 tr|Q18FE5|Q18FE5 HALWD@Lar N domain-containingtr|V4YJS7|V4YJS7 tr|L0JVR2|L0JVR2protein@OS=Haloquadratum 9ARCH@Lar 9EURY@Lar N domain-containing walsbyi N domain-containing strain protein@OS=unculturedDSM 16790 protein@OS=Natronococcus / HBSQ001@GN=HQ archaeon A07HR60@GN=A07HR603213A occultus SP4@GN=Natoc 01714 1300 tr|A0A0A0J1A7|A0A0A0J1A7 9MICO@Lar N domain-containing protein@OS=Knoellia sinensis KCTC 19936@GN=N802 05690 tr|U1P357|U1P357tr|U2YW45|U2YW45 9EURY@Uncharacterized 9EURY@Iron-sulfur cluster conserved binding protein protein@OS=Halarchaeum DUF2088@OS=Halorubrum acidiphilum sp. J07HR59@GN=J07HR59 MH1-52-1@GN=MBEHAL 01808 2010 tr|U2RFB6|U2RFB6tr|S3YF24|S3YF24tr|A0A0Q9KLZ1|A0A0Q9KLZ1 9ACTN@Lar9ACTN@PF09861 9MICO@Lar N domain-containing family N protein@OS=Propionibacterium domain-containing protein@OS=Propionibacterium protein@OS=Knoellia acidifaciens sp. sp. oral F0233@GN=HMPREF0682 Soil729@GN=ASG74 taxon 192 str. F0372@GN=HMPREF1531 09030 2062 00087 tr|B9LTI1|B9LTI1 HALLT@Lar N domain-containingtr|A0A1H8TGV0|A0A1H8TGV0 protein@OS=Halorubrum 9EURY@Lar lacusprofundi N domain-containing strain ATCC protein@OS=Halogranum 49239 / DSM 5036 / JCM amylolyticum@GN=SAMN04487948 8891 / ACAM 34@GN=Hlac 2581 1077 tr|A0A1J4VJQ0|A0A1J4VJQ0 9BACT@D-mannonatetr|A0A1G9IC68|A0A1G9IC68 epimerase@OS=Candidatus 9ACTN@Nickel-dependent Omnitrophica bacterium lactate CG1 racemase@OS=Tessaracoccus02 41 171@GN=AUJ76 00280 oleiagri@GN=SAMN04488242 0833 tr|D8JA35|D8JA35 HALJB@Lar N domain-containingtr|I5AYC7|I5AYC7tr|A0A1I1WSH0|A0A1I1WSH0 protein@OS=Halalkalicoccus 9DELT@Lar N 9RHOB@Lardomain-containing jeotgali strain N DSM domain-containing protein@OS=Desulfobacter 18796 / CECT protein@OS=Sulfitobacter 7217 / JCM postgatei14584 / KCTC 2ac9@GN=DespoDRAFT brevis@GN=SAMN04488523 4019 / B3@GN=HacjB3 00198 05830 10454 tr|A0A1T4TG00|A0A1T4TG00 9RHIZ@Nickel-dependent lactate racemase@OS=Consotaella salsifontis@GN=SAMN05428963 1313 tr|S3Y0M9|S3Y0M9 9MICO@Lar N domain-containing protein@OS=Dermabacter sp. HFH0086@GN=HMPREF1484 00945 tr|A0A1H3CLE6|A0A1H3CLE6tr|A0A1W2AP93|A0A1W2AP93 9GAMM@Lar N 9FIRM@Lardomain-containing N domain-containing protein@OS=Aidingimonas protein@OS=Sporomusa halophila@GN=SAMN05443545 malonica@GN=SAMN04488500 10633 10617 tr|A0A1H1RQD0|A0A1H1RQD0 9ACTN@Lar N domain-containing protein@OS=Actinopolymorpha singaporensis@GN=SAMN04489717 2507 tr|A0A022KW47|A0A022KW47tr|A0A1R1IE01|A0A1R1IE01 9ACTN@Lar 9MICO@Lar N domain-containingdomain-containing protein@OS=Brachybacterium protein@OS=Tessaracoccus murissp. ZS01@GN=BJN44 UCD-AY4@GN=D641 07505 0110215 tr|A8ZXL7|A8ZXL7tr|A0A0B7MMQ0|A0A0B7MMQ0 DESOH@Iron-sulfur cluster 9FIRM@Lar binding protein@OS=Desulfococcus N domain-containing protein@OS=Syntrophaceticus oleovorans strain DSM 6200 schinkii@GN=SSCH / Hxd3@GN=Dole 330009 1169 tr|A0A1P8NGN4|A0A1P8NGN4tr|A0A0M8KP28|A0A0M8KP28tr|A0A291GTI3|A0A291GTI3tr|A0A2A3YEG8|A0A2A3YEG8tr|C7MAY6|C7MAY6tr|A0A097IIK5|A0A097IIK5 BRAFD@Uncharacterized 9CORY@Lar9MICO@Lar 9MICO@Predicted 9MICO@Lar N N domain-containing Ndomain-containing domain-containing conserved D-mannonate protein@OS=Brachybacterium protein@OS=Brachybacterium epimerase@OS=Brachybacteriumprotein@OS=Corynebacterium protein@OS=Brachybacteriumprotein@OS=Brachybacterium faecium ginsengisoli@GN=CFK41 sp. doosanensealimentarium@GN=CIK66strain sp. P6-10-X1@GN=BH708 SW0106-09@GN=Y09 ATCC CAU43885 212 / DSM 00395 = DSM 17870481012760 2213 45436@GN=CDOO / NCIB 9860@GN=Bfae 12430 31130 tr|A0A1W1YTN9|A0A1W1YTN9tr|A0A0M9DW31|A0A0M9DW31 9DELT@Lar N domain-containing 9DELT@Lar N protein@OS=Desulfobacteriumdomain-containing protein@OS=Candidatus vacuolatum DSM Magnetomorum 3385@GN=SAMN02746065 sp. HK-1@GN=MHK 101366 010846 tr|A0A220UCU2|A0A220UCU2tr|A0A0G3HGU4|A0A0G3HGU4tr|S2WWM3|S2WWM3 9ACTN@Lar 9MICO@Lar 9CORY@Lar N domain-containingN domain-containing N domain-containing protein@OS=Propionimicrobium protein@OS=Brachybacterium protein@OS=Corynebacterium sp. lymphophilum VR2415@GN=CFK39 uterequi@GN=CUTER ACS-093-V-SCH5@GN=HMPREF9306 07900 10165 01708 tr|A0A1G6AVS5|A0A1G6AVS5 9DELT@Lar N domain-containing protein@OS=Desulfonatronum thiosulfatophilum@GN=SAMN05660653 00604 tr|A0A1F8QWN7|A0A1F8QWN7 9CHLR@Lar N domain-containing protein@OS=Chloroflexi bacterium RBG 16 57 8@GN=A2147 07715 tr|A0A291GKM7|A0A291GKM7 9MICO@Lar N domain-containing protein@OS=Brachybacterium sp. VM2412@GN=CFK38 03115 tr|C0QAE0|C0QAE0 DESAH@Lar N domain-containingtr|A0A1F8P890|A0A1F8P890 protein@OS=Desulfobacterium 9CHLR@Lar autotrophicumN domain-containing strain ATCCprotein@OS=Chloroflexi 43914 / DSM 3382 bacterium / HRM2@GN=HRM2 RBG 16 48 8@GN=A2Z1416160 01260 tr|A0A1H1JFR5|A0A1H1JFR5 9RHOB@Lar N domain-containing protein@OS=Pseudovibrio sp. Tun.PSC04-5.I4@GN=SAMN04515695 6074 tr|A0A1M5UNV9|A0A1M5UNV9tr|A0A1Q3TII2|A0A1Q3TII2 9DELT@Lar N domain-containing 9CHLR@Lar N protein@OS=Desulfofustis domain-containing protein@OS=Chloroflexi glycolicus DSM 9705@GN=SAMN02745124 bacterium 54-19@GN=BGO39 01283 27545 tr|A0A0S8JHJ1|A0A0S8JHJ1 9BACT@D-mannonate epimerase@OS=candidate division BRC1 bacterium SM23 51@GN=AMJ85 07750 tr|A0A285M3Q4|A0A285M3Q4 9RHIZ@Lar N domain-containing protein@OS=Cohaesibacter sp. ES.047@GN=SAMN04515647 1291 tr|U4QJC7|U4QJC7 TEPAE@Lar N domain-containing protein@OS=Tepidanaerobactertr|A0A1H9VSL0|A0A1H9VSL0 acetatoxydans 9CORY@Nickel-dependent strain DSM 21804 / JCM 16047 lactate / Re1@GN=TEPIRE1 racemase@OS=Corynebacterium 1890 cystitidis DSM 20524@GN=SAMN05661109 02372 tr|A0A1F5CYG6|A0A1F5CYG6tr|A0A2H9I1H9|A0A2H9I1H9 9ARCH@Lar 9ARCH@DUF2088 N domain-containing domain-containing protein@OS=Candidatus protein@OS=Candidatus Bathyarchaeota Bathyarchaeota archaeon RBGarchaeon 16 57 B24-2@GN=CP083 9@GN=A3K69 06050 03000 tr|A0A1H1MIM0|A0A1H1MIM0 9ACTN@Nickel-dependent lactate racemase@OS=Microlunatus soli@GN=SAMN04489812 0150 tr|A0A1G0Y147|A0A1G0Y147 9BACT@D-mannonate epimerase@OS=Lentisphaeraetr|S5TL16|S5TL16tr|Q8FMZ1|Q8FMZ1tr|A0A2A9DM71|A0A2A9DM71 bacterium GWF2 499CORY@Lar 21@GN=A2X48COREF@Lar 9CORY@Nickel-dependent 05850N domain-containingN domain-containing protein@OS=Corynebacterium protein@OS=Corynebacterium lactate racemase@OS=Corynebacterium maris efficiens DSM strain 45190@GN=B841 renale@GN=ATK06 DSM 44549 / YS-31410445 0770 / AJ 12310 / JCM 11189 / NBRC 100395 OX=196164 tr|A0A151BPX2|A0A151BPX2tr|A0A1U7MG16|A0A1U7MG16 9ARCH@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Candidatus protein@OS=Sporomusa Bathyarchaeota sphaeroides archaeon DSM 2875@GN=SPSPH B26-2@GN=AYL32 00090 001670 tr|A0A0Q6F876|A0A0Q6F876tr|A0A0A0DNB0|A0A0A0DNB0 9ACTN@Lar 9SPIO@Lar N domain-containing N domain-containing protein@OS=Marmoricola protein@OS=Alkalispirochaeta sp. Leaf446@GN=ASG49 odontotermitis@GN=JY97 13065 16230 tr|A0A1F5DDI5|A0A1F5DDI5tr|A0A2E8ECF1|A0A2E8ECF1tr|A0A151BRS6|A0A151BRS6 9ARCH@Lar 9ARCH@DUF2088 9ARCH@Lar N tr|M8E5Y2|M8E5Y2domain-containing N domain-containing protein@OS=Candidatus 9BACL@Lar protein@OS=Candidatus N domain-containing Bathyarchaeota Bathyarchaeota protein@OS=Brevibacillus archaeon archaeonarchaeon@GN=CL673 RBG 13 B63@GN=AYL33 60borstelensis 20@GN=A3K81 01260AK1@GN=I532 002490 02315 03540 tr|S0FEY0|S0FEY0 RUMCE@Lar N domain-containing protein@OS=Ruminiclostridium cellobioparum subsp. termitidis CT1112@GN=CTER 5373 tr|A0A1G0ZRC2|A0A1G0ZRC2 9BACT@D-mannonate epimerase@OS=Lentisphaerae bacterium GWF2 50 93@GN=A2X45 20680 tr|D1CF32|D1CF32 THET1@Lar N domain-containingtr|G2TI07|G2TI07 BACCO@Lar protein@OS=Thermobaculum N domain-containing terrenum protein@OS=Bacillus strain ATCC BAA-798 coagulans / YNP1@GN=Tter 36D1@GN=Bcoa 0620 1745 tr|A0A1M4U5Q0|A0A1M4U5Q0 9FIRM@Lar N domain-containing protein@OS=Alkalibacter saccharofermentans DSM 14828@GN=SAMN02746064 00653 tr|A0A1G1BAH9|A0A1G1BAH9tr|A0A081C7Y2|A0A081C7Y2 9BACT@D-mannonate 9BACT@Lar epimerase@OS=Melioribacter N domain-containing sp. protein@OS=Candidatus GWF2 38 21@GN=A2X65 10230 Vecturithrix granuli@GN=U27 00585 tr|A0A1F8Q864|A0A1F8Q864tr|A0A1E7DSM6|A0A1E7DSM6 9CHLR@Lar N domain-containing 9BACI@DUF2088 protein@OS=Chloroflexi domain-containing protein@OS=Domibacillus bacterium RBG 16 54 18@GN=A2Z16 iocasae@GN=BA724 13770 15995 tr|A0A101WEI9|A0A101WEI9 9FIRM@Lar N domain-containing protein@OS=Clostridia bacterium BRH c25@GN=APF77 16770 tr|A0A117SKG0|A0A117SKG0tr|G8NRY0|G8NRY0 9FIRM@D-mannonate GRAMM@Lar epimerase@OS=Clostridia N domain-containing bacterium protein@OS=Granulicella BRH c25@GN=APF77 18065 mallensis strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8@GN=AciX8 0744 tr|A0A1G0R2M8|A0A1G0R2M8tr|A0A1G1CAZ7|A0A1G1CAZ7tr|A0A081BP76|A0A081BP76tr|R6NH85|R6NH85 9BACT@D-mannonate 9CLOT@Lar 9BACT@Lar 9BACT@D-mannonate epimerase@OS=Ignavibacteria N domain-containing N domain-containing epimerase@OS=Lentisphaerae protein@OS=Clostridium protein@OS=Candidatus bacterium RBG 13 36 8@GN=A2V66 bacterium Moduliflexussp. CAG RIFOXYB12 07245 flocculans@GN=U14 FULL 65 16@GN=A3K19 03443 03220 tr|A0A1I2KFB4|A0A1I2KFB4tr|A0A1I4DR26|A0A1I4DR26tr|A0A1H0IS24|A0A1H0IS24tr|A0A0U2W7Y1|A0A0U2W7Y1tr|K6DKW5|K6DKW5 9BACL@Lartr|A0A0M2T4P1|A0A0M2T4P1 9BACL@Lar N 9BACL@Lardomain-containing 9BACI@Lar N domain-containing9BACL@Lar N domain-containing N9BACI@Lar domain-containingprotein@OS=Planifilum N domain-containing protein@OS=Paenibacillus N domain-containing protein@OS=Paenibacillus protein@OS=Bacillus protein@OS=Paenibacillus fulgidum@GN=SAMN04488025 protein@OS=Bacillus sp. 1 bataviensis12@GN=SAMN03159341 sp. yr247@GN=SAMN04487897 naphthalenovorans@GN=IJ22 LMG campisalis@GN=WQ57 10198 21833@GN=BABA 102360 11269 0035511846 43420 tr|A0A1T5G6E9|A0A1T5G6E9tr|A0A1F3M1L4|A0A1F3M1L4tr|L7VRR9|L7VRR9 9BACT@Nickel-dependenttr|A0A1H2DZZ7|A0A1H2DZZ7tr|D2R8B4|D2R8B4 9BACT@D-mannonate THES1@Lar lactate Nepimerase@OS=Bacteroidetes domain-containing PIRSD@Lar racemase@OS=Alkalitalea 9BACT@Lar N protein@OS=Thermoclostridium domain-containing saponilacus@GN=SAMN03080601bacterium N domain-containing GWF2 49 14@GN=A2X22 protein@OS=Pirellula stercorarium01744 protein@OS=Verrucomicrobium 04880 strain ATCCstaleyi 35414 strain / DSM ATCC 8532 sp. 27377 / GAS474@GN=SAMN05444156NCIMB / DSM11754@GN=Cst 6068 / ICPB c25250 4128@GN=Psta 0410 1048 tr|A0A1N6SGQ0|A0A1N6SGQ0 9BACI@Lar N domain-containing protein@OS=Domibacillus enclensis@GN=SAMN05443094 102425 tr|Q24XE7|Q24XE7 DESHY@Lar N domain-containing protein@OS=Desulfitobacterium hafniense strain Y51@GN=DSY1506 tr|A0A1I5Y2Y1|A0A1I5Y2Y1tr|E8V0E2|E8V0E2tr|I3ZMP9|I3ZMP9 9FIRM@Nickel-dependent TERRK@Lar TERSS@Lar N N domain-containing lactatedomain-containing racemase@OS=Caldicoprobacter protein@OS=Terriglobus protein@OS=Terriglobus faecalis@GN=SAMN05444406 roseus saanensis strain strain DSM 1359 ATCC 18391 BAA-1853 / NRRL B-41598 / DSM 23119/ KBS 63@GN=Terro/ SP1PR4@GN=AciPR4 4320 3673 tr|A0A1R1BLA5|A0A1R1BLA5 9BACL@DUF2088 domain-containing protein@OS=Paenibacillus sp. FSL H7-0331@GN=BK127 27265 tr|A0A1Q8QTX6|A0A1Q8QTX6 9FIRM@Transcriptional regulator@OS=Desulfosporosinus sp. OL@GN=DSOL 2905 tr|A3ZQS9|A3ZQS9tr|A0A286REU8|A0A286REU8 9BACT@Lar 9BACT@Putative N domain-containing D-mannonate protein@OS=Blastopirellula epimerase@OS=Thermogutta marina DSM terrifontis@GN=THTE 3645@GN=DSM3645 1865 20647 tr|A9WA54|A9WA54tr|A0A1R1CFG4|A0A1R1CFG4 CHLAA@Lar N domain-containingtr|A0A0K9GXL0|A0A0K9GXL0 9BACL@DUF2088 protein@OS=Chloroflexus domain-containing 9BACI@Lar Naurantiacus protein@OS=Paenibacillus domain-containing strain ATCC protein@OS=Bacillus 29366 sp. FSL/ DSM H7-0331@GN=BK127 635 loiseleuriae@GN=AC625 / J-10-fl@GN=Caur 02180 3552 19410 tr|A0A1Q2MIW7|A0A1Q2MIW7tr|A0A1J4U7S1|A0A1J4U7S1tr|A0A1I2BGL2|A0A1I2BGL2tr|A0A1W6LJS4|A0A1W6LJS4tr|A0A1G0YNT1|A0A1G0YNT1tr|A6DP73|A6DP73tr|A0A1M5YR91|A0A1M5YR91tr|A0A1G3WSN2|A0A1G3WSN2 9BACT@Lar 9BACT@D-mannonate 9BACT@Nickel-dependenttr|A0A1G7Q507|A0A1G7Q507 9BACT@Lartr|A0A142WSN4|A0A142WSN4 9BACT@LarN domain-containing 9BACT@D-mannonate N domain-containing epimerase@OS=IgnavibacteriaN protein@OS=Limihaloglobusdomain-containing lactate 9FIRM@Lar 9BACT@D-mannonate racemase@OS=Thermophagus protein@OS=Sedimentisphaera epimerase@OS=Lentisphaerae N protein@OS=Lentisphaera sulfuriphilus@GN=SMSP2domain-containing9BACT@Nickel-dependent bacterium 9PLAN@Lar CG1epimerase@OS=Tenericutes xiamenensis@GN=SAMN0544438002 37 salicampi@GN=STSP1 0268035@GN=AUJ54 Nprotein@OS=Sporobacter bacteriumdomain-containing araneosa 05225GWF2 lactateHTCC2155@GN=LNTAR 0039744 16@GN=A2017 bacterium racemase@OS=Terriglobus11330 protein@OS=Planctomyces termitidis GWF2 11245 DSM 0231738 8@GN=A210210068@GN=SAMN02745823 roseus@GN=SAMN05444167 05270 sp. SH-PL14@GN=VT03 02757 07340 3749 tr|A0A1U9NM93|A0A1U9NM93tr|A0A1G0PHX0|A0A1G0PHX0tr|A0A0S8JQH1|A0A0S8JQH1tr|A0A1Q2HNH7|A0A1Q2HNH7 9BACT@Lar 9BACT@D-mannonate 9BACE@D-mannonate 9BACT@Lar N domain-containing N domain-containing epimerase@OS=Ignavibacteria protein@OS=Anaerohalosphaera epimerase@OS=Bacteroides protein@OS=Sedimentisphaera bacterium lusitana@GN=STSP2 sp. GWB2 SM23 35 62@GN=AMS26 6b@GN=A2068 cyanobacteriorum@GN=L21SP3 01794 0357520845 00566 tr|A0A0K0GEF1|A0A0K0GEF1tr|A0A0M0KVY8|A0A0M0KVY8 9FIRM@Lar 9BACI@Lar N domain-containing N domain-containing protein@OS=Bacilli protein@OS=Bacillus bacterium koreensis@GN=AMD01VT-13-104@GN=WH51 1777001995 tr|A0A1G3Q1W1|A0A1G3Q1W1tr|A0A0E9LX76|A0A0E9LX76tr|A0A1F3P0W2|A0A1F3P0W2tr|H3K8I4|H3K8I4 9SPIR@D-mannonate 9BACT@Novel tr|A0A142XXC9|A0A142XXC99BACT@D-mannonate D-mannonate epimerase@OS=Spirochaetes9FIRM@Lar epimerase@OS=Bacteroidetes dehydrogenase@OS=Geofilum N domain-containing bacterium 9BACT@Lar GWF1 bacterium rubicundum 41 5@GN=A2096 protein@OS=MegamonasRBGN domain-containing JCM13 42 15548@GN=JCM15548 0418015@GN=A2Y71 14040 protein@OS=Pirellula 12436 funiformis YIT 11815@GN=HMPREF9454 sp. SH-Sr6A@GN=VN12 01557 05510 tr|A0A0J1I7B5|A0A0J1I7B5 9FIRM@Lar N domain-containingtr|D6V8J2|D6V8J2 protein@OS=Peptococcaceae 9BRAD@Lar bacterium N domain-containing CEB3@GN=CEB3 c29490 protein@OS=Afipia sp. 1NLS2@GN=AfiDRAFT 3185 tr|G0GE33|G0GE33tr|R4K1T0|R4K1T0 SPITZ@Lar N domain-containing CLOPA@Lar protein@OS=Spirochaeta N domain-containing thermophila protein@OS=Clostridium strain ATCC 700085 / DSM 6578 pasteurianum / Z-1203@GN=Spith BC1@GN=Clopa 0380 1579 tr|A0A1Q3QQB1|A0A1Q3QQB1tr|A0A1G0ZVQ2|A0A1G0ZVQ2tr|A0A180FHH1|A0A180FHH1tr|A0A180F9R2|A0A180F9R2tr|W7YR95|W7YR95 9BACT@D-mannonate 9BACT@Lar 9BACT@D-mannonate9BACT@Lar tr|A0A0G3WDD0|A0A0G3WDD09BACT@Lartr|A0A255ELL0|A0A255ELL0 Nepimerase@OS=AcidobacterialesN N domain-containingdomain-containing domain-containing epimerase@OS=Lentisphaerae protein@OS=Bacteroidales protein@OS=Bacteroidales protein@OS=Saccharicrinis bacterium 59-55@GN=BGO25 bacterium9CLOT@Lar 9ACTN@Lar bacterium RIFOXYC12bacterium 18440 fermentans Barb6XT@GN=Barb6XT Barb4@GN=Barb4N FULL domain-containing 60 NDSM 16@GN=A2498 domain-containing 9555 00441 = 00710JCM 16535 21142@GN=JCM21142 protein@OS=Clostridium protein@OS=Propionibacteriaceae 93697 aceticum@GN=CACET bacterium c24300 NML 150081@GN=CGZ91 02415 tr|A0A0A1MYE6|A0A0A1MYE6 9BACI@Lar N domain-containing protein@OS=Oceanobacillus oncorhynchi@GN=BN997 04500 tr|A0A101VC14|A0A101VC14 9FIRM@Lar N domain-containing protein@OS=Desulfitibacter sp. BRH c19@GN=APF76 15050 tr|A0A0M2U735|A0A0M2U735 9FIRM@D-mannonate epimerase@OS=Clostridiales bacterium PH28 bin88@GN=SY88 05155 tr|A0A1G0QWY1|A0A1G0QWY1tr|A0A1G0UER1|A0A1G0UER1tr|A0A1G0WUC5|A0A1G0WUC5tr|I6YYC6|I6YYC6 MELRP@Lartr|A0A1F5BT84|A0A1F5BT84 9BACT@D-mannonate 9BACT@D-mannonate9BACT@D-mannonateN domain-containingtr|A0A0G3ECA0|A0A0G3ECA0tr|A0A1H5F682|A0A1H5F682 protein@OS=Melioribacter epimerase@OS=Ignavibacteria epimerase@OS=Ignavibacteriaepimerase@OS=Ignavibacteria 9BACT@D-mannonate roseus 9MICO@Nickel-dependent bacterium bacteriumbacterium9BACT@Lar strain JCM GWC2 RIFOXYB2RIFOXYA2 17771 epimerase@OS=Candidatus 36 12@GN=A2080/ P3M-2@GN=MROSFULLN FULL domain-containing 36 37 17@GN=A3J84 7@GN=A2330 04270 lactate 2332 00680 03580 racemase@OS=Haloactinobacterium protein@OS=Kiritimatiella Atribacteria bacterium RBG glycovorans@GN=L21SP4 16 35 8@GN=A2V94 album@GN=SAMN04488554 07385 00649 1242 tr|A0A1W5ZZL0|A0A1W5ZZL0 9BACI@DUF2088 domain-containing protein@OS=Halobacillus mangrovi@GN=HM131 18280 tr|A0A1M4VNA4|A0A1M4VNA4tr|A0A1G0YS08|A0A1G0YS08 9BACT@Lar N domain-containing 9BACT@D-mannonate protein@OS=Mariniphaga anaerophila@GN=SAMN05444274 epimerase@OS=Lentisphaerae 102150 bacterium GWF2 52 8@GN=A2X49 03815 tr|X5DK65|X5DK65tr|G8UIV5|G8UIV5 9BACT@Lar TANFA@Lartr|U4KPY9|U4KPY9 N domain-containing N domain-containingtr|A0A239QRE3|A0A239QRE3 protein@OS=Draconibacterium 9MOLU@Lar protein@OS=Tannerella N domain-containingorientale@GN=FH5T forsythia strain 9MICO@Nickel-dependent ATCC 18290 43037protein@OS=Acholeplasma / JCM 10827 / FDC 338@GN=BFO lactate brassicae@GN=BN85315560 3309 racemase@OS=Ruaniaceae bacterium KH17@GN=SAMN06298212 10714 tr|G5IJ68|G5IJ68 9CLOT@Lar N domain-containing protein@OS=Hungatella hathewayi WAL-18680@GN=HMPREF9473 03546 tr|A0A0L8VE06|A0A0L8VE06tr|A0A202DJ32|A0A202DJ32tr|S0FJ10|S0FJ10 9BACT@Lar 9BACT@D-mannonatetr|A0A1C7IGA9|A0A1C7IGA9 N domain-containing RUMCE@Lar epimerase@OS=bacterium protein@OS=Sunxiuqinia N domain-containing 9FIRM@D-mannonate E082017@GN=BVX97 dokdonensis@GN=NC99 protein@OS=Ruminiclostridium 02865 07330 epimerase@OS=Blautia cellobioparum sp. YL58@GN=A4V09 subsp. termitidis CT1112@GN=CTER 20390 5288 tr|C1F2M3|C1F2M3tr|A0A1M6END5|A0A1M6END5tr|A0A1M3MDR8|A0A1M3MDR8tr|A0A1Y1RXT0|A0A1Y1RXT0tr|A0A1F5AVK3|A0A1F5AVK3 ACIC5@Lartr|F5YQS4|F5YQS4 N tr|R6LP74|R6LP74domain-containing 9BACT@Lar 9BACT@D-mannonate 9SPIO@D-mannonatetr|A0A1M4TXZ2|A0A1M4TXZ2 N domain-containingprotein@OS=Acidobacterium 9BACT@Lar epimerase@OS=PaludibacterTREPZ@Lar 9FIRM@Lar epimerase@OS=Marispirochaeta protein@OS=Tangfeifania capsulatumN domain-containing NN domain-containing domain-containing strain sp.9CLOT@Nickel-dependent ATCC diversioriginum@GN=SAMN0544428047-17@GN=BGP01 51196 aestuarii@GN=B4O97 protein@OS=Candidatus / DSM 11244protein@OS=Treponema protein@OS=Firmicutes 13055 / JCM 7670 10385 / NBRC 10753 lactate 15755 Aminicenantes / NCIMB racemase@OS=Lactonifactor 13165primitiabacterium / 161@GN=ACPbacterium strain CAG ATCC2683RBG 16 BAA-887 63 16@GN=A2W03 longoviformis/ DSM 12427 01575 / ZAS-2@GN=TREPRDSM 17459@GN=SAMN02745158 1367 00631 tr|R9JAH8|R9JAH8 9FIRM@Lar N domain-containing protein@OS=Lachnospiraceae bacterium 28-4@GN=C807tr|A0A1F4F1E9|A0A1F4F1E9 01783 9PROT@Lar N domain-containing protein@OS=Betaproteobacteria bacterium RIFCSPLOWO2 12 FULL 67 28@GN=A3F77 06470 tr|A0A1I6MXP4|A0A1I6MXP4tr|A0A1G0XNG8|A0A1G0XNG8 9BACT@Lartr|A0A1I5RUL5|A0A1I5RUL5 tr|A0A1G9SF76|A0A1G9SF76N domain-containing protein@OS=Granulicella 9BACT@D-mannonate 9FIRM@Larpectinivorans@GN=SAMN05421771 9FIRM@Lar epimerase@OS=Lentisphaerae N domain-containing N 3659 domain-containing protein@OS=Oscillibacter bacterium protein@OS=Halarsenatibacter GWF2 45 14@GN=A2020 sp. PC13@GN=SAMN05216343 08080 silvermanii@GN=SAMN04488692 110103 12823 tr|R9M1P0|R9M1P0 9FIRM@Lar N domain-containing protein@OS=Anaerotruncus sp. G32012@GN=C814 00294 tr|A0A239HND1|A0A239HND1tr|F8EWW5|F8EWW5 9BACT@Nickel-dependent TRECH@Lar lactate racemase@OS=Granulicella N domain-containing rosea@GN=SAMN05421770 protein@OS=Treponema 102481 caldarium strain ATCC 51460 / DSM 7334 / H1@GN=Spica 0183 tr|R9MZ47|R9MZ47 9FIRM@Lar N domain-containing protein@OS=Lachnospiraceae bacterium 10-1@GN=C819 01566 tr|A0A1I7L5D4|A0A1I7L5D4 9BACL@Lar N domain-containing protein Fragment@OS=Alicyclobacillus macrosporangiidus@GN=SAMN05421543 12542 tr|A0A174FAW3|A0A174FAW3 9CLOT@DUF2088 domain-containing protein@OS=Hungatella hathewayi@GN=DWX31 03775 tr|W7QHI8|W7QHI8 9ALTE@Lar N domain-containing protein@OS=Catenovulum agarivorans DS-2@GN=DS2 17487 tr|A0A1D3TTZ3|A0A1D3TTZ3 9FIRM@Lar N domain-containing protein@OS=Anaerobium acetethylicum@GN=SAMN05421730 101133 tr|A0A1I2IX66|A0A1I2IX66tr|F5YBB3|F5YBB3 9BACT@Lar TREAZ@LarN domain-containing N domain-containing protein@OS=Sunxiuqinia protein@OS=Treponema elliptica@GN=SAMN05216283 10733 azotonutricium strain ATCC BAA-888 / DSM 13862 / ZAS-9@GN=TREAZ 1897 tr|R5F5G6|R5F5G6 9CLOT@Lar N domain-containing protein@OS=Clostridium bolteae CAG tr|A0A1I4R2P3|A0A1I4R2P3 9DELT@Uncharacterized conserved protein tr|R6K2N1|R6K2N1tr|A0A1H7YUY7|A0A1H7YUY7 9CLOT@Lar N domain-containing 9FIRM@Lar protein@OS=Clostridium N domain-containing clostridioforme CAG protein@OS=Hydrogenoanaerobacterium saccharovorans@GN=SAMN05216180 0226 tr|E8X1V6|E8X1V6tr|A0A1F3H705|A0A1F3H705 GRATM@Lartr|A0A0J8GLQ7|A0A0J8GLQ7 N 9BACT@D-mannonate domain-containingtr|M5E3X7|M5E3X7tr|C0D6R0|C0D6R0 protein@OS=Granulicella epimerase@OS=Bacteroidetes 9ALTE@D-mannonate9FIRM@Predicted tundricola strain 9FIRM@Lar ATCCbacterium BAA-1859 GWD2 / DSM45D-mannonate epimerase@OS=Catenovulum23@GN=A2W86N 23138 domain-containing / MP5ACTX9@GN=AciX9 05070 epimerase@OS=Halanaerobium 2072 protein@OS= maritimum@GN=XM47 asparagiforme saccharolyticum 18140 DSM 15981@GN=CLOSTASPAR subsp. saccharolyticum DSM 6643@GN=HSACCH 04957 02423 tr|A0A1C0BMC2|A0A1C0BMC2 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. W14A@GN=A7X67 13995 tr|K6Z5F8|K6Z5F8 9ALTE@Lar N domain-containing protein@OS=Paraglaciecola arctica BSs20135@GN=GARC 1703 tr|A0A1Z5HU61|A0A1Z5HU61 9THEO@Lar N domain-containing protein@OS=Calderihabitans maritimus@GN=KKC1 19690 tr|A0A1Y4RTC4|A0A1Y4RTC4 9FIRM@Lar N domain-containing protein@OS=Lachnoclostridium sp. An14@GN=B5E84 04980 tr|A0A1G4G3Z2|A0A1G4G3Z2tr|E1R7H9|E1R7H9 9PORP@Lar SEDSS@Lartr|R9KRD3|R9KRD3 N domain-containing N domain-containing protein@OS=Petrimonas 9FIRM@Lar protein@OS=Sediminispirochaeta mucosa@GN=ING2E5A N domain-containing 0406 smaragdinae protein@OS=Lachnospiraceae strain DSM 11293 / JCM 15392 / SEBRbacterium 4228@GN=Spirs A2@GN=C810 3596 00145 tr|Q1ART1|Q1ART1 RUBXD@Lar N domain-containing protein@OS=Rubrobacter xylanophilus strain DSM 9941 / NBRC 16129@GN=Rxyl 2987 tr|A0A084JF01|A0A084JF01tr|A0A0J1DKI6|A0A0J1DKI6 9FIRM@Lar N domain-containing protein@OS= 9FIRM@Lar celerecrescens@GN=IO98 N domain-containing 21040 protein@OS=Peptococcaceae bacterium 1109@GN=AA931 10270 tr|A0A0G3HEA3|A0A0G3HEA3tr|A0A1H9UK44|A0A1H9UK44 9CORY@Nickel-dependent9CORY@Lar N domain-containing lactate racemase@OS=Corynebacteriumprotein@OS=Corynebacterium uterequi@GN=CUTER cystitidis DSM 20524@GN=SAMN05661109 01340 01838 tr|A0A0A5GEW0|A0A0A5GEW0 9BACI@Lar N domain-containing protein@OS=Pontibacillus marinus BH030004 = DSM 16465@GN=N783 00460 tr|A0A1R3T4P4|A0A1R3T4P4tr|A0A1I4AES0|A0A1I4AES0tr|A0A1Z9T9E6|A0A1Z9T9E6 9PORP@Lar 9BACT@Nickel-dependent N domain-containing lactate protein@OS=Porphyromonadaceaeracemase@OS=Proteiniphilum 9BACT@D-mannonatetr|A0A0D8HD67|A0A0D8HD67 saccharofermentans@GN=PSM36 bacteriumepimerase@OS=Kiritimatiellaceae KH3CP3RA@GN=SAMN05216357 3416 9ACTN@Lar 10357 bacterium N TMED266@GN=CBE26 domain-containing 02965 protein@OS=Acidithrix ferrooxidans@GN=AXFE 32670 tr|R4KK67|R4KK67 9FIRM@Lar N domain-containing protein@OS=Desulfallas gibsoniae DSM 7213@GN=Desgi 1453 tr|A0A1Y4F4C9|A0A1Y4F4C9 9FIRM@Lar N domain-containing protein@OS=Blautia sp. An249@GN=B5F53 09925 tr|A0A1W9N8B0|A0A1W9N8B0tr|A0A0J8GLU3|A0A0J8GLU3tr|A0A1N6RIM9|A0A1N6RIM9 9SPIO@D-mannonate 9ALTE@D-mannonate epimerase@OS=Spirochaeta 9FIRM@Nickel-dependent epimerase@OS=Catenovulum sp. LUC14 lactate 002 racemase@OS=Halanaerobium19 maritimum@GN=XM47 P3@GN=B0D92 04840 17975 kushneri@GN=SAMN05421834 10321

tr|A0A1Y4WJV8|A0A1Y4WJV8 9FIRM@Lar N domain-containing protein@OS=Flavonifractor sp. tr|V7I8K0|V7I8K0An100@GN=B5E43 00925 9CLOT@Lar N domain-containing protein@OS=Youngiibacter fragilis 232.1@GN=T472 0202235 tr|K3WST1|K3WST1 GLOUD@Lar N domain-containing protein@OS=Globisporangiumtr|R5BYW4|R5BYW4tr|A0A0J1DPH6|A0A0J1DPH6 ultimum strain ATCC 2000069FIRM@Lar / CBS 805.95 / DAOM N9FIRM@D-mannonate BR144 domain-containing OX=431595 protein@OS=Blautia epimerase@OS=Peptococcaceae hydrogenotrophica bacterium CAG 1109@GN=AA931 04835 tr|F0RUP4|F0RUP4 SPHGB@Lar N domain-containing protein@OS=Sphaerochaeta globosa strain ATCC BAA-1886 / DSM 22777 / Buddy@GN=SpiBuddy 0573 tr|A0A067CLC1|A0A067CLC1 SAPPC@Lar N domain-containing protein@OS=Saprolegniatr|C5EL34|C5EL34 parasitica strain CBS 223.65@GN=SPRG 9FIRM@Lar 19554 N domain-containing protein@OS=Clostridiales bacterium 1 7 47FAA@GN=CBFG 02083 tr|A0A1Y4IT85|A0A1Y4IT85 9FIRM@Lar N domain-containing protein@OS=Gemmiger sp. An194@GN=B5F28 10915 tr|T0Q381|T0Q381tr|Q1IIJ2|Q1IIJ2 SAPDV@Lar KORVE@Lar N domain-containing N domain-containing protein@OS=Saprolegnia protein@OS=Koribactertr|R5F375|R5F375 diclina strain VS20@GN=SDRG versatilis strain 14445 9CLOT@Lar Ellin345@GN=Acid345 4308N domain-containing protein@OS=Clostridium bolteae CAG tr|A0A1C7IGE6|A0A1C7IGE6 9FIRM@Lar N domain-containing protein@OS=Blautia sp. YL58@GN=A4V09 20600

tr|R9LWR6|R9LWR6 9FIRM@Lar N domain-containing protein@OS=Oscillibacter sp. 1-3@GN=C816 03763 tr|A0A1J6IVE1|A0A1J6IVE1 NICAT@Lar N domain-containingtr|A0A0F0CLU8|A0A0F0CLU8 protein Fragment@OS=Nicotiana attenuata@GN=A4A49 45417 9CLOT@Lar N domain-containing protein@OS=Clostridium sp. FS41@GN=CLFS41 02100 tr|A0A135L170|A0A135L170 9BACI@Lar N domain-containing protein@OS=Tepidibacillus decaturensis@GN=U473 00840 tr|A0A0D6ZDG1|A0A0D6ZDG1 9BACI@Lar N domain-containing protein@OS=Bacillus subterraneus@GN=UB32 04440 tr|E3GDT4|E3GDT4 9FIRM@Lar N domain-containing protein@OS=Eubacterium callanderi@GN=ELI 2031 tr|A0A1Y4LC41|A0A1Y4LC41 9FIRM@Lar N domain-containing protein@OS=Pseudoflavonifractor sp. An184@GN=B5F19 11590 tr|R5HKD4|R5HKD4 9FIRM@Lar N domain-containing protein@OS=Roseburia inulinivorans CAG

tr|A0A1Y3SB57|A0A1Y3SB57 9FIRM@Lar N domain-containing protein@OS=Flavonifractor sp. An82@GN=B5G34 10990 rAAYXS|013269IMLrNdmi-otiigpoenFragment@OS=Flavonifractor sp. An52@GN=B5G06 12505 tr|A0A1Y3X2S6|A0A1Y3X2S6 9FIRM@Lar N domain-containing protein tr|C5ES51|C5ES51 9FIRM@Lar N domain-containing protein@OS=Clostridiales bacterium 1 7 47FAA@GN=CBFG 04557 tr|A0A0V8J4U9|A0A0V8J4U9tr|A0A1W2EG94|A0A1W2EG94 9BACI@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Fictibacillus protein@OS=Sporomusa enclensis@GN=AS030 malonica@GN=SAMN04488500 17830 12391 tr|R6RHE5|R6RHE5 9FIRM@Lar N domain-containing protein@OS=Firmicutes bacterium CAG tr|A0A098C2C7|A0A098C2C7 9PORP@Uncharacterized protein@OS=Fermentimonas caenicola@GN=ING2E5B 2329 tr|R6NTP3|R6NTP3 N 9FIRM@Lar domain-containing protein@OS=Lachnospiraceae bacterium CAG tr|A0A1I5PS57|A0A1I5PS57 9FIRM@Lar N domain-containing protein@OS=Oscillibacter sp. PC13@GN=SAMN05216343 106141 tr|H3GH40|H3GH40 PHYRM@Lar N domain-containing protein@OS=Phytophthora ramorum OX=164328 tr|D4J702|D4J702 9FIRM@Uncharacterizedtr|A0A0U1KN50|A0A0U1KN50 conserved protein DUF2088@OS=Coprococcus 9BACI@Lar catus GD/7@GN=CC1 N13270 domain-containing protein@OS=Paraliobacillus sp. PM-2@GN=BN1058 01720 tr|A0A162MPU7|A0A162MPU7 9FIRM@Lar N domain-containing protein@OS=Thermovenabulum gondwanense@GN=ATZ99 07230 tr|A0A1Y4THM7|A0A1Y4THM7 9FIRM@Lar N domain-containing protein@OS=Gemmiger sp. An120@GN=B5E65 11625 tr|W4H746|W4H746 9STRA@Lar N domain-containing protein@OS=Aphanomyces astaci@GN=H257 01187 tr|A0A1M5BA38|A0A1M5BA38Streptococcus 9CLOT@Lar N domain-containing protein@OS=Lactonifactor longoviformis DSM 17459@GN=SAMN02745158 03561 plurextorum DSM 22810@Protein LarA@GeneID G575 RS0102970 Desguin2017 tr|W2PR38|W2PR38tr|W2MRF7|W2MRF7tr|V9EIY3|V9EIY3tr|A0A0W8BYC3|A0A0W8BYC3 PHYPR@Lar PHYPN@Lar PHYPR@Lar N PHYNI@Lar Ndomain-containing N domain-containing domain-containing N domain-containing protein@OS=Phytophthora protein@OS=Phytophthora protein@OS=Phytophthora protein@OS=Phytophthoratr|R6ST95|R6ST95 parasiticaparasitica parasitica@GN=L914tr|R6UBM0|R6UBM0 strainP1569@GN=F443 nicotianae@GN=AM587 INRA-310@GN=PPTG 15519 16123 9CLOT@Lar 15675 10011168 9FIRM@Lar N domain-containing N domain-containing protein@OS=Clostridium protein@OS=Oscillibacter sp. CAG sp. CAG tr|A0A154BPS0|A0A154BPS0 ANASB@Lar N domain-containing protein@OS=Anaerosporomusa subterranea@GN=AXX12 11945 tr|A0A0P1AA56|A0A0P1AA56tr|A0A024UUJ8|A0A024UUJ8tr|A0A024UW81|A0A024UW81 PLAHL@Lar 9STRA@Lar 9STRA@Lar N domain-containing N Ndomain-containing domain-containing protein@OS=Plasmopara protein@OS=Aphanomyces protein@OS=Aphanomycestr|A0A1I4FR18|A0A1I4FR18 halstedii invadans@GN=H310 OX=4781 invadans@GN=H310 00562 00562 9FIRM@Nickel-dependent lactate racemase@OS=Halanaerobium salsuginis@GN=SAMN02983006 00495

tr|R5EBM6|R5EBM6 9FIRM@Lar N domain-containing protein@OS=Firmicutes bacterium CAG tr|C5EPZ2|C5EPZ2 9FIRM@Lar N domain-containing protein@OS=Clostridiales bacterium 1 7 47FAA@GN=CBFG 03798 tr|A0A1H4AHC9|A0A1H4AHC9 9BACI@Lar N domain-containing protein@OS=Thalassobacillus cyri@GN=SAMN05421743 10493 tr|R5BQP1|R5BQP1 9FIRM@Lartr|V2Y1K6|V2Y1K6 N domain-containing protein@OS=Blautia 9FIRM@Larhydrogenotrophica CAG N domain-containing protein@OS=Catonella morbi ATCC 51271@GN=GCWU0000282 003125 tr|M4C0Z9|M4C0Z9 HYAAE@Lar N domain-containing protein@OS=Hyaloperonospora arabidopsidis strain Emoy2 OX=559515 tr|G9RQW3|G9RQW3 9FIRM@Lar N domain-containing protein@OS=Subdoligranulum sp. 4 3 54A2FAA@GN=HMPREF1032 02632 tr|A0A1F8T9W4|A0A1F8T9W4tr|A0A0T6AP98|A0A0T6AP98tr|A0A1M4YVA6|A0A1M4YVA6tr|A0A1I6D4K3|A0A1I6D4K3 9BACT@Lar 9CHLR@Lar 9FIRM@Lar 9FIRM@Lar N N domain-containing domain-containingN domain-containing N domain-containing protein@OS=Armatimonadetes protein@OS=Chloroflexi protein@OS=Desulfofundulus protein@OS=Desulfallas bacterium bacterium geothermicus australicus RBG 19FTCSP1-3@GN=XU14 DSM DSMCOMBO 11792@GN=SAMN02745218 3669@GN=SAMN05660706 62 14@GN=A2Z37 C0027G0021 00995 01428 10599 tr|A0A1S9C8E2|A0A1S9C8E2tr|A0A1V2MC05|A0A1V2MC05 9FIRM@Lar 9FIRM@Lar N Ndomain-containing domain-containing protein@OS=Epulopiscium protein@OS=Epulopiscium sp. AS2M-Bin001@GN=ATN31 sp. SCG-C07WGA-EpuloA2@GN=AN641 00925 03105 tr|A0A1Z5HWJ6|A0A1Z5HWJ6 9THEO@Lar N domain-containing protein@OS=Calderihabitans maritimus@GN=KKC1 29150 tr|K8Z7B8|K8Z7B8tr|W7TWH1|W7TWH1 NANGC@Lar 9STRA@Lar N domain-containing N domain-containing protein@OS=Nannochloropsis protein@OS=Nannochloropsis gaditana gaditana@GN=Naga strain CCMP526@GN=NGA 100076g23 0492300 tr|A0A024GPG5|A0A024GPG5tr|A0A1Z5JMA6|A0A1Z5JMA6 9STRA@Lartr|A0A1G3MQW0|A0A1G3MQW0 FISSO@Lar N domain-containing N domain-containing protein@OS=Albugo protein@OS=Fistulifera candida@GN=BN9tr|R6JE56|R6JE56 9SPIR@Lar solaris@GN=FisN 093200 N 12Lh161domain-containing 9CLOT@Lar protein@OS=Spirochaetes N domain-containing bacterium protein@OS=Clostridium GWC1 61 12@GN=A2004 06365 clostridioforme CAG tr|A0A1U7CP58|A0A1U7CP58 9BACT@Lar N domain-containing protein@OS=Paludisphaera borealis@GN=BSF38 02205 tr|D1PPQ1|D1PPQ1 9FIRM@Lar N domain-containing protein@OS=Subdoligranulum variabile DSM 15176@GN=SUBVAR 06368 tr|A0A1I6D5X4|A0A1I6D5X4tr|A0A142YDQ1|A0A142YDQ1tr|A0A142YAR8|A0A142YAR8tr|A0A1U7CQ62|A0A1U7CQ62tr|A0A225DFV6|A0A225DFV6 9FIRM@Lar 9PLAN@Lar N domain-containing 9PLAN@Lar 9BACT@Lar 9BACT@Iron-sulfurN domain-containing N domain-containing protein@OS=DesulfallasN domain-containing cluster protein@OS=Planctomyces binding protein@OS=Planctomyces protein@OS=Paludisphaera protein@OS=Fimbriiglobusgeothermicus DSMsp. SH-PL62@GN=VT85 3669@GN=SAMN05660706 sp. SH-PL62@GN=VT85borealis@GN=BSF38 ruber@GN=FRUB 07105 07644 0239502552 10613 tr|I0IGU2|I0IGU2 PHYMF@Lar N domain-containing protein@OS=Phycisphaera mikurensis strain NBRC 102666 / KCTC 22515 / FYK2301M01@GN=PSMK 23210 tr|A0A142XSL9|A0A142XSL9 9BACT@Lar N domain-containing protein@OS=Gemmata sp. SH-PL17@GN=VT84 36525 tr|C4GA67|C4GA67 9FIRM@Lar N domain-containing protein@OS=Shuttleworthia satelles DSM 14600@GN=GCWU000342 00220 tr|M5TG62|M5TG62 9BACT@Lar N domain-containing protein@OS=Rhodopirellula sp. SWK7@GN=RRSWK 04927 tr|A0A1I2WQN9|A0A1I2WQN9 9FIRM@Lar N domain-containing protein@OS=Desulfotomaculum arcticum DSM 17038@GN=SAMN05660649 03564 tr|M5TRY6|M5TRY6 9BACT@Lar N domain-containing protein@OS=Rhodopirellula sallentina SM41@GN=RSSM 06746 tr|A0A1U7GI96|A0A1U7GI96 9BACT@Lar N domain-containing protein@OS=Planctomycetales bacterium 71-10@GN=BGO49 23665 tr|A0A2G1W5F7|A0A2G1W5F7tr|Q7UEX3|Q7UEX3 RHOBA@Lar 9BACT@D-mannonate N domain-containing epimerase@OS=Rhodopirellula protein@OS=Rhodopirellula baltica bahusiensis@GN=CEE69 strain DSM 10527 / NCIMB 16650 13988 / SH1@GN=RB10494 tr|F4LS83|F4LS83 TEPAE@Lartr|A0A1U7GFZ8|A0A1U7GFZ8 N domain-containingtr|A0A1D9FSG2|A0A1D9FSG2 9BACT@Lar protein@OS=Tepidanaerobacter N domain-containing 9CLOT@Lar N domain-containingprotein@OS=Planctomycetales acetatoxydans strain protein@OS=Clostridium DSM 21804 bacterium / JCM 1604771-10@GN=BGO49 formicaceticum@GN=BJL90 / Re1@GN=TEPIRE1 17160 0147 08140 tr|A0A0J1B7Z0|A0A0J1B7Z0 RHOIS@Putative D-mannonate epimerase@OS=Rhodopirellulatr|A0A1M5AGA7|A0A1M5AGA7 islandica@GN=RISK 005642 9DELT@Nickel-dependent lactate racemase@OS=Desulfacinum infernum DSM 9756@GN=SAMN02745206 01701 tr|A0A0Q0W7F8|A0A0Q0W7F8tr|A0A0M2U2Q4|A0A0M2U2Q4 9BACT@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Candidatus protein@OS=Clostridiales Cloacimonas bacterium sp. SDB@GN=APR54 PH28 bin88@GN=SY88 12035 16480 tr|A0A142Y3G6|A0A142Y3G6 9BACT@Lar N domain-containing protein@OS=Pirellula sp. SH-Sr6A@GN=VN12 14430 tr|A0A090KGC8|A0A090KGC8tr|E8R273|E8R273 ISOPI@Lar 9BACT@Uncultured N domain-containing bacterium genomeprotein@OS=Isosphaera assembly Metasoil pallida fosmids strain resub@OS=uncultured ATCC 43644 / DSM 9630 bacterium / IS1B@GN=Isop OX=77133 2938 tr|E8QWG0|E8QWG0 ISOPI@Lar N domain-containing protein@OS=Isosphaera pallida strain ATCC 43644 / DSM 9630 / IS1B@GN=Isop 0250 tr|A0A1U7MCZ9|A0A1U7MCZ9tr|A0A101VEY9|A0A101VEY9 9FIRM@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Sporomusa protein@OS=Desulfitibacter sphaeroides sp. DSM BRH 2875@GN=SPSPH c19@GN=APF76 0889034610 tr|A0A0M2U4U3|A0A0M2U4U3 9FIRM@Lar N domain-containing protein@OS=Clostridiales bacterium PH28 bin88@GN=SY88 20415 tr|G7WIY8|G7WIY8 DESOD@Uncharacterized conserved protein DUF2088@OS=Desulfosporosinustr|A0A0C2V797|A0A0C2V797tr|V7I564|V7I564 9CLOT@Lar orientis 9BACL@Lar strain N domain-containing ATCC N domain-containing 19365 / DSM protein@OS=Youngiibacter 765 protein@OS=Paenibacillus / NCIMB 8382 / VKM fragilis B-1628@GN=Desor 232.1@GN=T472sp. VKM B-2647@GN=SD70 02133854282 13520 tr|F4PFW8|F4PFW8 BATDJ@Lar N domain-containing protein@OS=Batrachochytrium dendrobatidis strain JAM81 / FGSC 10211@GN=BATDEDRAFT 93261 tr|A0A101E8Q8|A0A101E8Q8 9FIRM@Lartr|J0N5R3|J0N5R3 N domain-containing 9CLOT@PF09861 protein@OS=Clostridia family protein@OS=Clostridium bacterium 41 269@GN=XD50 sp. MSTE9@GN=HMPREF1141 0233 2726 tr|A0A1I6DZA1|A0A1I6DZA1tr|A0A1I6SML9|A0A1I6SML9tr|A0A101V689|A0A101V689tr|A0A1R1BI31|A0A1R1BI31tr|A0A090TXN1|A0A090TXN1 tr|A0A0H4L1J6|A0A0H4L1J69FIRM@Lar N domain-containing 9PSEU@Lar 9FIRM@Lar 9BACL@Lartr|I8RMP7|I8RMP7 9RHOB@Lar9VIBR@Iron-sulfur N domain-containingprotein@OS=Desulfallas N domain-containingN domain-containing N 9FIRM@Lardomain-containing cluster protein@OS=Saccharopolyspora binding N protein@OS=Desulfitibacter domain-containing protein@OS=Paenibacillusgeothermicus protein@OS=Vibrioprotein@OS=Marinovum DSM protein@OS=Pelosinus 3669@GN=SAMN05660706 maritimus@GN=JCM19240 sp. flava@GN=SAMN05660874 sp. algicola BRH FSL c19@GN=APF76 H7-0331@GN=BK127 DG fermentans 898@GN=MALG 12155 B4@GN=FB4474 17830 03238 0401329715 2602 tr|L0D8V0|L0D8V0 SINAD@Lar N domain-containing protein@OS=Singulisphaeratr|A0A0U2UET8|A0A0U2UET8 acidiphila strain 9BACL@Lar ATCC BAA-1392 N domain-containing / DSM 18658 protein@OS=Paenibacillus / VKM B-2454 / MOB10@GN=Sinac naphthalenovorans@GN=IJ22 0851 00250 tr|L0D8N3|L0D8N3 SINAD@Lartr|A0A1B7XDL9|A0A1B7XDL9 N domain-containing protein@OS=Singulisphaera 9DELT@Lar tr|A0A073IRS0|A0A073IRS0N domain-containingtr|A0A1Y4GF49|A0A1Y4GF49 acidiphila strain protein@OS=Halodesulfovibrio ATCC 9BACT@Lar BAA-1392 9BACT@Lar N domain-containing / DSM N domain-containing 18658 spirochaetisodalis@GN=SP90 / VKM protein@OS=Synergistes B-2454 protein@OS=Cloacibacillus / MOB10@GN=Sinac 07915 jonesii@GN=EH55 sp. 0817 An23@GN=B5F39 04540 08025 tr|A0A1I2YNV6|A0A1I2YNV6tr|A0LP86|A0LP86tr|A0A1H3Q7I1|A0A1H3Q7I1tr|A0A1I4RLE5|A0A1I4RLE5 SYNFM@Lar 9FIRM@Lartr|A0A1Z9GUB1|A0A1Z9GUB1 N domain-containingN 9PSEU@Lar domain-containing 9PSEU@Lar Ntr|R4K330|R4K330 N domain-containing domain-containingprotein@OS=Syntrophobacter protein@OS=Desulfotomaculum 9PROT@Lar CLOPA@Lar protein@OS=Saccharopolyspora protein@OS=Saccharopolyspora N domain-containing N domain-containing fumaroxidans arcticum protein@OS=Proteobacteria DSMstrain protein@OS=Clostridium 17038@GN=SAMN05660649 shandongensis@GN=SAMN05216215DSM antimicrobica@GN=SAMN05421805 10017 / MPOB@GN=Sfum bacterium pasteurianum TMED154@GN=CBD14 04524 3568BC1@GN=Clopa 101602104631 1151 08245 tr|A0A1I2SCK1|A0A1I2SCK1tr|A0A1H3TIH0|A0A1H3TIH0 9FIRM@Lartr|A0A1I5TAD6|A0A1I5TAD6tr|G0VMV6|G0VMV6 N domain-containing9PSEU@Lar MEGEL@Lar N domain-containing9FIRM@Lar protein@OS=Desulfotomaculum N domain-containing N domain-containing protein@OS=Saccharopolyspora protein@OS=Megasphaera protein@OS=Oscillibacter arcticum DSM 17038@GN=SAMN05660649 shandongensis@GN=SAMN05216215 elsdenii sp. PC13@GN=SAMN05216343 DSM 20460@GN=MELS 01865 0562 1083191152 tr|A0A0D8I8C8|A0A0D8I8C8tr|E7GL36|E7GL36tr|G9PZH9|G9PZH9 CLOSY@Lar 9BACT@Lar 9CLOT@Lar N domain-containing N domain-containing N domain-containing protein@OS= protein@OS=Synergistes protein@OS=Clostridium symbiosum WAL-14163@GN=HMPREF9474 sp. aceticum@GN=CACET 3 1 syn1@GN=HMPREF1006 c11220 01625 01041 tr|D3R148|D3R148tr|E7GGU5|E7GGU5 MAGIU@Lar N domain-containing CLOSY@Lar N protein@OS=Mageeibacillus domain-containing protein@OS= indolicus symbiosum strain UPII9-5@GN=HMPREF0868WAL-14163@GN=HMPREF9474 0582 00138 tr|A0A133SJB2|A0A133SJB2tr|D4M8X1|D4M8X1 tr|A0A1G4FLZ0|A0A1G4FLZ09FIRM@Lar 9BACT@Uncharacterized N domain-containing conserved 9FIRM@Lar protein@OS=Megasphaera protein N domain-containing DUF2088@OS=Fretibacterium protein@OS=Sporanaerobactersp. MJR8396C@GN=HMPREF3201 fastidiosum@GN=SY1 sp. PP17-6a@GN=PP176A 0075111400 1813 tr|A0A0U2W5V4|A0A0U2W5V4tr|A0A223KKI8|A0A223KKI8 9BACL@Lar N domain-containing 9BACI@Lar protein@OS=Paenibacillus N domain-containing protein@OS=Bacillus naphthalenovorans@GN=IJ22 cohnii@GN=BC6307 14460 01185 tr|A0A1G6SCF4|A0A1G6SCF4 PEPNI@Lar N domain-containing protein@OS=Peptococcus niger@GN=SAMN04489866 101278 tr|A0A1G8XNT2|A0A1G8XNT2tr|A0A1G9WWQ3|A0A1G9WWQ3tr|A0A0D2J6J5|A0A0D2J6J5 9CLOT@Lar 9FIRM@LarN domain-containingtr|A0A268K4F4|A0A268K4F4tr|S6A0R6|S6A0R6 9DELT@Iron-sulfurN domain-containing protein@OS=Natronincola BACPJ@Lar binding 9BACI@Lar protein@OS=Megasphaera protein@OS=Dethiosulfatarculus N domain-containing N domain-containing ferrireducens@GN=SAMN05660472 protein@OS=Bacillus paucivorans@GN=SAMN05660299 protein@OS=Bacillus sandiegensis@GN=X474 sp. strain sp.00279 7884-1@GN=CHI06 JF8@GN=M493 12840 01698 04995 13175 tr|D7GRJ7|D7GRJ7 9FIRM@Uncharacterizedtr|A0A2A8IIG1|A0A2A8IIG1tr|K6DP16|K6DP16 conserved 9BACI@Lar protein9BACI@Lar N DUF2088@OS=butyrate-producing domain-containing N domain-containing protein@OS=Bacillus protein@OS=Bacillus bacterium bataviensis SS3/4@GN=CK3 sp. AFS006103@GN=CN481 LMG 21833@GN=BABA 06270 2580106815 tr|B0KD84|B0KD84 tr|A0A0M2SUX6|A0A0M2SUX6THEP3@Lartr|A0A1S2QTW1|A0A1S2QTW1tr|A0A0K9GTE6|A0A0K9GTE6tr|A0A1Q9Q1S7|A0A1Q9Q1S7 N domain-containing 9BACI@Lar 9BACI@Lar 9BACI@Lar protein@OS=Thermoanaerobacter 9BACI@Lar N N domain-containing Ndomain-containing Ndomain-containing domain-containing protein@OS=Bacillus protein@OS=Bacillus protein@OS=Bacillus protein@OS=Bacillus pseudethanolicus campisalis@GN=WQ57 sp. strainloiseleuriae@GN=AC625 sp.MUM MRMR6@GN=BTR25ATCC 116@GN=BIV60 33223 / 39E@GN=Teth39 13780 2505510640 08745 1977 tr|A0A1G9SM61|A0A1G9SM61 9FIRM@Lartr|A0A1Y6EXT3|A0A1Y6EXT3tr|A0A2B2CBY8|A0A2B2CBY8 N domain-containingtr|C6CXN8|C6CXN8 9BACI@Lar protein@OS=Dendrosporobacter 9BACI@LarPAESJ@Lar N domain-containing NN domain-containing protein@OS=Bacillus quercicolus@GN=SAMN04488502 protein@OS=Paenibacillus protein@OS=Bacillus sp. sp.OV166@GN=SAMN05444673 AFS073361@GN=COJ96 sp. strain 10455JDR-2@GN=Pjdr2 06215 1444 1789 tr|A0A2C1Z3M5|A0A2C1Z3M5tr|A0A0M1N1U0|A0A0M1N1U0 9BACI@Lar 9BACL@Lar N domain-containing N domain-containing protein@OS=Bacillus protein@OS=Paenibacillus sp. AFS037270@GN=COD92 solani@GN=AM231 12005 25430 tr|A0A0Q9YE49|A0A0Q9YE49tr|A0A0M2PNV3|A0A0M2PNV3tr|A0A1L3MTY5|A0A1L3MTY5 9BACI@Lar 9BACI@Lar 9BACI@Lar N domain-containing N N domain-containing domain-containing protein@OS=Virgibacillus protein@OS=Bacillus protein@OS=Bacillus weihaiensis@GN=A9C19soli@GN=ACA30 sp. SA1-12@GN=WQ54 06490 1428001070 tr|A0A1G9UPM0|A0A1G9UPM0tr|A0A2A2IHL7|A0A2A2IHL7 9BACI@Lartr|A0A081P9I3|A0A081P9I3 9BACI@Lar N domain-containing N domain-containing 9BACL@Lar protein@OS=Bacillus N domain-containingprotein@OS=Virgibacillus sp. OK048@GN=SAMN05443253 protein@OS=Paenibacillus profundi@GN=CIL05 tyrfis@GN=ET33 05805 104276 26195 tr|A0A1R1F0Z4|A0A1R1F0Z4tr|A0A1H0VM45|A0A1H0VM45 9BACL@Lar N domain-containing 9BACI@Lartr|I8RJN4|I8RJN4 N domain-containing protein@OS=Paenibacillus 9FIRM@Lar N domain-containing protein@OS=Bacillus rhizosphaerae@GN=BK138 protein@OS=Pelosinustr|R5FC90|R5FC90 salsus@GN=SAMN05216565 9CLOT@Lar fermentans N 03845 domain-containing B4@GN=FB4 10753 protein@OS=Clostridium 2439 bolteae CAG tr|A0A1X9MCU3|A0A1X9MCU3tr|A0A229URH0|A0A229URH0 9BACI@Lar N 9BACL@Lardomain-containing N domain-containing protein@OS=Bacillus protein@OS=Paenibacillus krulwichiae@GN=BkAM31D rigui@GN=CF651 16140 11815 tr|A0A089INU1|A0A089INU1tr|A0A177KZX3|A0A177KZX3 9BACL@Lar N domain-containing 9BACI@Lar N domain-containing protein@OS=Paenibacillus protein@OS=Domibacillus sp. FSL H7-0737@GN=H70737 aminovorans@GN=AWH49 15705 04480 tr|F6DN71|F6DN71 DESRL@Lar N domain-containing protein@OS=Desulfotomaculum ruminis strain ATCC 23193 / DSM 2154 / NCIMB 8452 / DL@GN=Desrutr|M1Z3F9|M1Z3F9 2419 9FIRM@Uncharacterized protein@OS= ultunense Esp@GN=CUESP1 0537 tr|N4WU61|N4WU61 9BACI@Lar N domain-containingtr|F7NLM9|F7NLM9 9FIRM@Larprotein@OS=Gracilibacillus N domain-containing halophilus protein@OS=Acetonema YIM-C55.5@GN=J416 longum DSM 09724 6540@GN=ALO 15017 tr|Q3ACI4|Q3ACI4 CARHZ@Lar N domain-containingtr|A0A0K0G8N1|A0A0K0G8N1 protein@OS=Carboxydothermustr|A0A1V4HAF4|A0A1V4HAF4tr|H6NB52|H6NB52 9FIRM@Lartr|A0A091FJF4|A0A091FJF4 9BACL@Lar Nhydrogenoformans domain-containing 9BACL@Lar N domain-containing N domain-containing 9DELT@Lar strainprotein@OS=Bacilli ATCC protein@OS=Paenibacillus N domain-containing BAA-161 protein@OS=Paenibacillus bacterium / DSM protein@OS=Smithella VT-13-104@GN=WH51 6008 mucilaginosus / Z-2901@GN=CHY ferrarius@GN=BC351 3016@GN=PM3016 sp. SCADC@GN=ER57 11845 1316 10950 5315 01235 tr|A0A0U2ILV4|A0A0U2ILV4tr|A1HM30|A1HM30tr|F7NJT8|F7NJT8 9BACL@Lar 9FIRM@Lar 9FIRM@Lar NN domain-containingdomain-containing N domain-containing protein@OS=Thermosinusprotein@OS=Paenibacillus protein@OS=Acetonema carboxydivorans naphthalenovorans@GN=IJ22 longum DSM Nor1@GN=TcarDRAFT6540@GN=ALO 11230 11729 2570 tr|A0A1H9PI96|A0A1H9PI96tr|A0A1M7PXV2|A0A1M7PXV2tr|A0A1I4INC7|A0A1I4INC7tr|A0A1N6REF5|A0A1N6REF5 9BACI@Lar 9BACI@Lar 9BACI@Lar N N domain-containing domain-containing9BACI@Lar Ntr|A1HMS3|A1HMS3 domain-containing N domain-containing protein@OS=Gracilibacillus tr|S5Z005|S5Z005protein@OS=Gracilibacillus 9FIRM@Lar protein@OS=Gracilibacillus N protein@OS=Domibacillus domain-containingBACPJ@Lar N ureilyticus@GN=SAMN04487944 domain-containingorientalis@GN=SAMN04487943 protein@OS=Thermosinuskekensis@GN=SAMN05216179 enclensis@GN=SAMN05443094 protein@OS=Bacillustr|R6TGK7|R6TGK7 carboxydivorans sp. 10219210510 strain 9FIRM@Lar2566 JF8@GN=M493 Nor1@GN=TcarDRAFT N 102103domain-containing 10140 protein@OS=Oscillibacter 2032 sp. CAG tr|I0I1C7|I0I1C7 CALAS@Lar N domain-containing protein@OS=Caldilineatr|A0A1Y0IV17|A0A1Y0IV17 aerophilatr|A0A1C1A8T7|A0A1C1A8T7tr|A0A1I4I4M8|A0A1I4I4M8 strain DSM 9BACL@Lar14535 9BACL@Lar 9BACL@Lar / JCM N 11387domain-containing N N domain-containing domain-containing / NBRC 104270 protein@OS=Tumebacillus protein@OS=Paenibacillus protein@OS=Paenibacillus / STL-6-O1@GN=CLDAP avium@GN=CBW65 sp. pectinilyticus@GN=A8709 1 12@GN=SAMN0315934110250 03290 23835 106313 tr|D5DZQ4|D5DZQ4tr|W4VGE1|W4VGE1 BACMQ@Lar 9BACI@Iron-sulfurtr|A0A0C2QT06|A0A0C2QT06 N domain-containing cluster binding protein@OS=Bacillus9BACL@Lar protein@OS=Gracilibacillus N domain-containing megaterium boraciitolerans protein@OS=Paenibacillus strain ATCC JCM 12872 21714@GN=JCM21714 / QMB1551@GN=BMQ sp.tr|R5FBF8|R5FBF8 VKM B-2647@GN=SD70 9CLOT@Iron-sulfur 850 3433 cluster-binding 09155 protein@OS=Clostridium bolteae CAG tr|A0A1N7IND9|A0A1N7IND9tr|A0A168J5L0|A0A168J5L0tr|A0A1R1BGD7|A0A1R1BGD7 9BACI@Lar N 9BACL@Lardomain-containing 9BACL@LarN domain-containing protein@OS=Salimicrobium N domain-containing protein@OS=Paenibacillus protein@OS=Paenibacillus flavidum@GN=SAMN05421687 antarcticus@GN=PBAT sp. FSL H7-0331@GN=BK127 101628 22975 31090 tr|A0A1G8RJJ6|A0A1G8RJJ6tr|A0A1B8W7Z9|A0A1B8W7Z9tr|A0A1Y5KIK2|A0A1Y5KIK2 9BACI@Lartr|A0A0U1KU63|A0A0U1KU63 N domain-containing 9BACI@Lar9BACL@Lar N N domain-containing domain-containing 9FIRM@Iron-sulfur protein@OS=Salimicrobium protein@OS=Bacillus protein@OS=Paenibacillus cluster binding halophilum@GN=SAMN04490247 protein@OS=Sporomusa sp. FJAT-26390@GN=A7975 sp. MY03@GN=B1748 sp. An4@GN=SpAn4DRAFT 107402435 17295 1944 tr|A0A167FSX5|A0A167FSX5tr|A0A1G9XB38|A0A1G9XB38 9BACL@Lar 9BACL@Lar N Ndomain-containing domain-containing protein@OS=Paenibacillus protein@OS=Paenibacillus crassostreae@GN=PNBC sp. yr247@GN=SAMN04487897 05590 101542 tr|A0A0Q9LCG6|A0A0Q9LCG6tr|A0A1H4JC45|A0A1H4JC45 9BACL@Lar 9BACL@Lar N domain-containing N domain-containing protein@OS=Paenibacillus protein@OS=Paenibacillus sp. Soil522@GN=ASG81 sp. GP183@GN=SAMN05443246 03970 0306 tr|A0A0D5NFS3|A0A0D5NFS3tr|A0A0F2JI08|A0A0F2JI08 9BACL@Lartr|A0A0M2SSY3|A0A0M2SSY3 N domain-containing 9FIRM@Iron-sulfur protein@OS=Paenibacillus cluster 9BACI@Lar binding Nprotein@OS=Desulfosporosinus domain-containing beijingensis@GN=VN24 tr|R5BVE0|R5BVE0protein@OS=Bacillus 9FIRM@Larsp. I2@GN=UF75 06060 campisalis@GN=WQ57 N domain-containing 0666 protein@OS=Blautia 17210 hydrogenotrophica CAG tr|A0A154BQT1|A0A154BQT1tr|A0A0F2JG82|A0A0F2JG82tr|A0A0M2PI75|A0A0M2PI75tr|A0A1A5XRL8|A0A1A5XRL8 ANASB@Lar 9FIRM@Iron-sulfur 9BACI@Lar N domain-containing 9BACL@Lar N cluster domain-containing bindingN domain-containing protein@OS=Anaerosporomusa protein@OS=Desulfosporosinus protein@OS=Bacillus protein@OS=Brevibacillus sp. SA1-12@GN=WQ54 subterranea@GN=AXX12tr|R5XM66|R5XM66 sp. I2@GN=UF75 sp. WF146@GN=A6764 9CLOT@Lar 10720 N2185 domain-containing 07525 04485 protein@OS=Clostridium bartlettii CAG tr|A0A1R1CJT1|A0A1R1CJT1tr|A0A259UN26|A0A259UN26tr|A0A259UH66|A0A259UH66 9BACL@Lar N domain-containingtr|A0A2B2C272|A0A2B2C272tr|Q5KYI1|Q5KYI1 9FIRM@Lar 9FIRM@Lar N GEOKA@Hypotheticaldomain-containingNprotein@OS=Paenibacillus domain-containing 9BACI@Lar protein@OS=Sporomusa N conservedprotein@OS=Sporomusa domain-containing sp. protein@OS=Geobacillus FSL H8-0548@GN=BK133 protein@OS=Bacillus silvacetica acidovorans kaustophilus DSM DSMsp. 10669@GN=SPSIL AFS073361@GN=COJ9626700 3132@GN=SPACI strain HTA426@GN=GK1970 21280 37690 12800 tr|A0A1Q8QUI0|A0A1Q8QUI0tr|A0A0V8IZT6|A0A0V8IZT6 9FIRM@Iron-sulfur 9BACI@Lar Ncluster domain-containing bindingtr|R6WC66|R6WC66 protein@OS=Desulfosporosinus protein@OS=Fictibacillus 9FIRM@Uncharacterized enclensis@GN=AS030 sp.conserved OL@GN=DSOL protein DUF2088@OS=Firmicutes 287320180 bacterium CAG tr|A4A022|A4A022 9BACT@Lar N domain-containing protein@OS=Blastopirellula marina DSM 3645@GN=DSM3645 05939 tr|A0A1U7MB87|A0A1U7MB87tr|E5WFY4|E5WFY4 9FIRM@Lar 9BACI@Iron-sulfur N domain-containing cluster protein@OS=Sporomusabinding protein@OS=Bacillus sphaeroides sp. 2 A 57 CT2@GN=HMPREF1013 DSM 2875@GN=SPSPH 01359 41150 tr|A0A2C6C1U7|A0A2C6C1U7tr|A0A0M0EWG5|A0A0M0EWG5 9GAMM@Lar N domain-containing9BACI@Lar N domain-containingtr|I9LE82|I9LE82 protein@OS=Budviciatr|R6K2G0|R6K2G0tr|A0A1C7ID63|A0A1C7ID63 9FIRM@Lar protein@OS=Bacillus 9CLOT@Lar Naquatica@GN=CRN84 domain-containing 9FIRM@Lar N domain-containing butanolivorans@GN=AKG34 N domain-containing protein@OS=Pelosinus protein@OS=Clostridium 13740 protein@OS=Blautia fermentans clostridioforme12965 B4@GN=FB4 sp. YL58@GN=A4V09 CAG 3179 13965 tr|A0A1I1S1M4|A0A1I1S1M4tr|A0A1H8J8N1|A0A1H8J8N1 9BACI@Lar 9BACL@Lar N domain-containing N domain-containing protein@OS=Bacillus protein@OS=Lihuaxuellatr|R9M541|R9M541 sp. OV194@GN=SAMN05428981 9FIRM@Lar thermophila@GN=SAMN05444955 N domain-containing protein@OS=Oscillibacter 101153 12223 sp. 1-3@GN=C816 03762 tr|A1HPH3|A1HPH3 9FIRM@Lartr|A0A0U2UBT5|A0A0U2UBT5 N domain-containing protein@OS=Thermosinus9BACL@Lar N domain-containing carboxydivorans protein@OS=Paenibacillus Nor1@GN=TcarDRAFT naphthalenovorans@GN=IJ22 1827 33600 tr|F4PFH6|F4PFH6 BATDJ@Lar N domain-containing protein@OS=Batrachochytriumtr|A0A0P9C6N8|A0A0P9C6N8 dendrobatidis 9BACL@Lar strain JAM81 N domain-containing / FGSC 10211@GN=BATDEDRAFT protein@OS=Alicyclobacillus ferrooxydans@GN=AN477 93124 21040 tr|A0A154BVD0|A0A154BVD0 ANASB@Lar N domain-containing protein@OS=Anaerosporomusa subterranea@GN=AXX12 16870 tr|A0A1I2YGF6|A0A1I2YGF6tr|A0A1U7MBX2|A0A1U7MBX2 9FIRM@Lar N9FIRM@Lar domain-containing N domain-containing protein@OS=Desulfotomaculum protein@OS=Sporomusatr|R9KRE4|R9KRE4 arcticum sphaeroides9FIRM@Lar DSM N 17038@GN=SAMN05660649 domain-containing DSM 2875@GN=SPSPH protein@OS=Lachnospiraceae 37490 04401 bacterium A2@GN=C810 00155 tr|A4IPH5|A4IPH5 GEOTN@Iron-sulfur cluster binding protein@OS=Geobacillus thermodenitrificans strain NG80-2@GN=GTNG 1869 tr|A0A1N6RHP2|A0A1N6RHP2tr|A0A1S2LHK3|A0A1S2LHK3 tr|A0A0Q9HRR3|A0A0Q9HRR39BACI@Lar 9BACI@Lar N domain-containing N domain-containing 9BRAD@Lar protein@OS=Domibacillus protein@OS=Anaerobacillustr|J1GZL6|J1GZL6 N domain-containing 9CLOT@PF09861 protein@OS=Bosea enclensis@GN=SAMN05443094 arseniciselenatis@GN=BKP35family protein@OS=Clostridium sp. Root381@GN=ASE63 sp. MSTE9@GN=HMPREF1141 102132 11430 23180 2047 tr|A0A075KJH5|A0A075KJH5 9FIRM@Lar N domain-containing protein@OS=Pelosinus sp. UFO1@GN=UFO1 4661 tr|A0A1Y4CIW7|A0A1Y4CIW7 9ACTN@Lar N domain-containing protein@OS=Olsenella sp. An285@GN=B5F79 06765 tr|A0A061NWU8|A0A061NWU8tr|A0A1Y4RJ35|A0A1Y4RJ35 9BACL@Iron-sulfurtr|A0A1Y4E0E8|A0A1Y4E0E8 cluster 9FIRM@Lar bindingtr|A0A1D9FL28|A0A1D9FL28 9ACTN@Lar protein@OS=GeomicrobiumN domain-containing N domain-containing 9CLOT@Lar protein@OS=Lachnoclostridium N protein@OS=Collinsella sp.domain-containing JCM 19038@GN=JCM19038 protein@OS=Clostridium sp. sp. An14@GN=B5E84 An271@GN=B5F74 786 formicaceticum@GN=BJL90 11125 02385 09345 tr|A0A196QJ79|A0A196QJ79 9RHOB@Lartr|A0A1Y4WIQ2|A0A1Y4WIQ2 N domain-containing 9FIRM@Lar protein@OS=Sulfitobacter N domain-containing protein@OS=Flavonifractor geojensis@GN=A8B74 sp.18340 An10@GN=B5E42 11855 tr|A9EEW0|A9EEW0 9RHOB@Lar N domain-containing protein@OS=Sulfitobacter indolifex HEL-45@GN=OIHEL45 18901 tr|F4A0R5|F4A0R5 MAHA5@Iron-sulfur cluster binding tr|A0A0F0CG58|A0A0F0CG58protein@OS=Mahella australiensis 9CLOT@Lar strain N domain-containing DSM 15567 / protein@OS=Clostridium CIP 107919 / 50-1 BON@GN=Mahau sp. FS41@GN=CLFS41 1780 22510 tr|A0A1Y4GEM3|A0A1Y4GEM3 9BACT@Lar N domain-containing protein@OS=Cloacibacillus sp. An23@GN=B5F39 03635 tr|A0A142Y710|A0A142Y710 9BACT@Lar N domain-containing protein@OS=Pirellula sp. SH-Sr6A@GN=VN12 23020 tr|A0A1M4U0B7|A0A1M4U0B7 9THEO@Lar N domain-containing protein@OS=Caldanaerobiustr|A0A1Y1S361|A0A1Y1S361 fijiensis DSM 9SPIO@Lar 17918@GN=SAMN02746089 N domain-containing protein@OS=Marispirochaeta 00345 aestuarii@GN=B4O97 01290 tr|A0A1I7GS59|A0A1I7GS59tr|A0A1I7H036|A0A1I7H036tr|A0A073IXU6|A0A073IXU6 9BACL@Lar 9BACL@Lar 9RHOB@Lar N N domain-containing domain-containing N domain-containing protein@OS=Alicyclobacillus protein@OS=Alicyclobacillus protein@OS=Sulfitobacter macrosporangiidus@GN=SAMN05421543 macrosporangiidus@GN=SAMN05421543 pseudonitzschiae@GN=SUH3 07215 10328103156 tr|G1UVG8|G1UVG8tr|G5IGP0|G5IGP0 9DELT@Lar 9CLOT@Lar N domain-containing N domain-containing protein@OS=Desulfovibrio protein@OS=Hungatellatr|A0A1Y1RZG1|A0A1Y1RZG1 sp. 6 hathewayi1 46AFAA@GN=HMPREF1022 9SPIO@LarWAL-18680@GN=HMPREF9473 N domain-containing 02591 protein@OS=Marispirochaeta 02668 aestuarii@GN=B4O97 09595 tr|A0A1Q6ZA36|A0A1Q6ZA36tr|A0A1Y4RHS6|A0A1Y4RHS6 9CHLR@Lar Ntr|C0DAP6|C0DAP6 domain-containing 9FIRM@Lartr|A0A1Y1S1S8|A0A1Y1S1S8 N 9FIRM@Lar domain-containing protein@OS=Ktedonobacter N 9SPIO@Lardomain-containing protein@OS=Lachnoclostridium N domain-containing protein@OS= sp. 13 2 protein@OS=Marispirochaetaasparagiforme20CM 53 11@GN=AUH05sp. DSM An14@GN=B5E84 15981@GN=CLOSTASPAR aestuarii@GN=B4O97 01670 12435 06351 01625 tr|A0A1M7K6J4|A0A1M7K6J4 9RHOB@Lartr|G9YRH3|G9YRH3 N domain-containingtr|A0A1Y1S2L5|A0A1Y1S2L5 FLAPL@Lar protein@OS=RoseovariusN domain-containing 9SPIO@Lar protein@OS=Flavonifractor N domain-containing pacificus@GN=SAMN05444398 protein@OS=Marispirochaeta plautii ATCC 29863@GN=HMPREF0372 1259 aestuarii@GN=B4O97 02121 02890 tr|A0A1G8KDT4|A0A1G8KDT4tr|B0PF86|B0PF86tr|C5ELH2|C5ELH2 9FIRM@Lar 9RHOB@Lar 9FIRM@Lartr|G4Q5E0|G4Q5E0 N domain-containing N N domain-containing domain-containing ACIIR@Lar protein@OS=Anaerotruncus N domain-containing protein@OS=Salipigerprotein@OS=Clostridiales protein@OS=Acidaminococcus marinus@GN=SAMN04487993 colihominis bacterium DSM1 7 47FAA@GN=CBFG 17241@GN=ANACOL intestini strain 1004192 RyC-MR95@GN=Acin 02321 03465 2118 tr|A0A1Q7WYJ4|A0A1Q7WYJ4 9CHLR@Lartr|U2SRI0|U2SRI0 N domain-containingtr|A0A239GZ38|A0A239GZ38 9FIRM@Lar protein@OS=Ktedonobacter N domain-containing 9FIRM@Lartr|A0A154BPT5|A0A154BPT5 N protein@OS=Mitsuokella domain-containing sp. ANASB@Lar 13 protein@OS=Anaerovirgula1 20CM sp. N domain-containing oral3 54 taxon 15@GN=AUG45 131 protein@OS=Anaerosporomusa str. multivorans@GN=SAMN05446037 W9106@GN=HMPREF1985 00685 subterranea@GN=AXX12 02146 101920 11980 tr|A0A023DHI8|A0A023DHI8 9BACI@Lar N domain-containing protein@OS=Parageobacillus caldoxylosilyticus NBRC 107762@GN=GCA01S 049 00380 tr|A0A1I0DLC1|A0A1I0DLC1 9RHOB@Lar N domain-containingtr|C0CVW0|C0CVW0 protein@OS=Paracoccustr|R8W3U4|R8W3U4 9FIRM@Lar N domain-containing 9CLOT@Lar homiensis@GN=SAMN04489858 N domain-containing protein@OS= protein@OS=Butyricicoccusasparagiforme DSM 104171 15981@GN=CLOSTASPAR pullicaecorum 1.2@GN=HMPREF1526 01114 00851 tr|A0A1N7JQG0|A0A1N7JQG0tr|A0A0J6WZ91|A0A0J6WZ91 9RHOB@Lar 9FIRM@Lar N domain-containing N domain-containing protein@OS=Paracoccus protein@OS=Megasphaeratr|A0A1H2QN17|A0A1H2QN17 saliphilus@GN=SAMN05421772 cerevisiae 9FIRM@Lar DSM N domain-containing20462@GN=AB840 101198 protein@OS=Tepidimicrobium 02240 xylanilyticum@GN=SAMN05660923 00182 tr|A0A1G9UU21|A0A1G9UU21tr|D7GR36|D7GR36 9FIRM@Lar N domain-containing9FIRM@Uncharacterized protein@OS=Megasphaera conserved protein DUF2088@OS=butyrate-producing paucivorans@GN=SAMN05660299 bacterium SS3/4@GN=CK3 01257 04240 tr|A0A1G7TBQ7|A0A1G7TBQ7 9RHOB@Lar N domain-containing protein@OS=Sulfitobactertr|A0A1I5PSU4|A0A1I5PSU4 delicatus@GN=SAMN04489759 9FIRM@Lar N domain-containing protein@OS=Oscillibacter 106158 sp. PC13@GN=SAMN05216343 106142 tr|A0A1H8WJA2|A0A1H8WJA2 9FIRM@Lar N domain-containing protein@OS=Propionispora vibrioides@GN=SAMN04490178tr|A6CEC2|A6CEC2 11619 9PLAN@Transcriptional regulator@OS=Gimesia maris DSM 8797@GN=PM8797T 13650 tr|D1Y7Q0|D1Y7Q0tr|E7GTW7|E7GTW7 9BACT@Lar N CLOSY@Lar domain-containing N domain-containing protein@OS=Pyramidobacter protein@OS= symbiosum piscolens WAL-14163@GN=HMPREF9474 W5455@GN=HMPREF7215 04362 2445 tr|Q1ARS0|Q1ARS0 RUBXD@Lar N domain-containing protein@OS=Rubrobacter xylanophilus strain DSM 9941 / NBRC 16129@GN=Rxyl 2998 tr|A0A133SKJ7|A0A133SKJ7tr|A0A133SKJ0|A0A133SKJ0 9FIRM@Lar9FIRM@Lartr|A0A0B3VGL4|A0A0B3VGL4 NN domain-containingdomain-containing 9FIRM@Lar protein@OS=Megasphaeraprotein@OS=Megasphaera N domain-containing protein@OS=Terrisporobacter sp. MJR8396C@GN=HMPREF3201 othiniensis@GN=QX51 0026800272 16820 tr|A0A1S1R803|A0A1S1R803tr|R7XUP4|R7XUP4 9ACTN@Transcriptional 9ACTN@Lar N regulator@OS=Frankia domain-containing protein@OS=Nocardioides sp. Cc1.17@GN=CC117 sp. CF8@GN=CF8 12085 3038 tr|B4CUW1|B4CUW1 9BACT@Lar N domain-containing protein@OS=Chthoniobacter flavus Ellin428@GN=CfE428DRAFT 0474 tr|A0A1V2IIQ3|A0A1V2IIQ3 9ACTN@Transcriptional regulator@OS=Frankia asymbiotica@GN=BL253 03870 tr|A0A1G9STW6|A0A1G9STW6 9FIRM@Lartr|A0A0J6WZ47|A0A0J6WZ47 N domain-containing 9FIRM@Lar protein@OS=Megasphaera N domain-containing protein@OS=Megasphaera paucivorans@GN=SAMN05660299 cerevisiae DSM 20462@GN=AB840 00776 04515 tr|A0A1M5ZNI2|A0A1M5ZNI2 9FIRM@Lar N domain-containing protein@OS=Desulfosporosinus lacus DSM 15449@GN=SAMN02746098 03456 tr|A0A1L6LPZ9|A0A1L6LPZ9 9DELT@Transcriptional regulator@OS=Minicystis rosea@GN=A7982 09199 tr|A0A1H4CS38|A0A1H4CS38 9DELT@Lar N domain-containing protein@OS=Desulfuromusa kysingii@GN=SAMN05660420 02694 tr|A0A1M4WS71|A0A1M4WS71tr|A0A1I3KLW8|A0A1I3KLW8 9CLOT@Lar N domain-containing 9FIRM@Lar Nprotein@OS=Lactonifactor domain-containing protein@OS=Ruminococcaceae longoviformis DSM bacterium17459@GN=SAMN02745158 D5@GN=SAMN02910435 01696 00660 tr|A0A1U7CNB9|A0A1U7CNB9 9BACT@Lar N domain-containing protein@OS=Paludisphaera borealis@GN=BSF38 01900 tr|A0A225CZE5|A0A225CZE5 9BACT@Lar N domain-containing protein@OS=Fimbriiglobus ruber@GN=FRUB 09582 tr|G4Q5E6|G4Q5E6 ACIIR@FeS cluster-binding protein@OS=Acidaminococcus intestini strain RyC-MR95@GN=Acin 2124 tr|A0A166T492|A0A166T492 9ACTN@Lar N domain-containing protein@OS=Frankiatr|A0A085WJB7|A0A085WJB7 sp.tr|A0A0K1PIL2|A0A0K1PIL2 EI5c@GN=UG55 9DELT@Transcriptional 9DELT@Transcriptionaltr|A0A0K1PL91|A0A0K1PL91 regulator@OS=Hyalangium 100356 regulator@OS=Vulgatibacter 9DELT@Transcriptional minutum@GN=DB31 regulator@OS=Labilithrix incomptus@GN=AKJ08 luteola@GN=AKJ09 8263 3613 00962 tr|A0A1S1RJZ1|A0A1S1RJZ1 9ACTN@Transcriptional regulator@OS=Frankia sp. BMG5.36@GN=BCD48 22390 tr|A0A1S1QQH0|A0A1S1QQH0 9ACTN@Transcriptional regulator@OS=Frankiatr|S9PGY9|S9PGY9 sp. EUN1h@GN=BCD49 9DELT@Transcriptional regulator@OS=Cystobacter 16930 fuscus DSM 2262@GN=D187 010276 tr|A0A0S2W671|A0A0S2W671 9FIRM@Iron-sulfur cluster binding protein@OS=Intestinimonas butyriciproducens@GN=IB211 02379c tr|D3CX32|D3CX32tr|A8L878|A8L878 9ACTN@Lar FRASN@Lar N N domain-containing domain-containing protein@OS=Frankia protein@OS=Frankia sp. sp. EUN1f@GN=FrEUN1fDRAFT strain EAN1pec@GN=Franean1 2102 4168 tr|A0A0G2ZRM6|A0A0G2ZRM6 9DELT@Transcriptional regulator@OS=Archangium gephyra@GN=AA314 03055 tr|A0A1F8RLV1|A0A1F8RLV1 9CHLR@Lar N domain-containing protein@OS=Chloroflexi bacterium RBG 16 64 32@GN=A2W34 07685 tr|A0A142YI82|A0A142YI82 9PLAN@Lar N domain-containing protein@OS=Planctomyces sp. SH-PL62@GN=VT85 15880tr|A0A0Q7JZ42|A0A0Q7JZ42 9ACTN@Transcriptional regulator@OS=Angustibacter sp. Root456@GN=ASD06 16145

tr|R6YXW1|R6YXW1 9ACTN@Lar N domain-containing protein@OS=Collinsella sp. CAG tr|A0A1H0BDT0|A0A1H0BDT0 9FIRM@Lar N domain-containing protein@OS=Megasphaera paucivorans@GN=SAMN05660299 02720 tr|A0A0H4WYP3|A0A0H4WYP3 9DELT@Transcriptional regulator@OS=Myxococcus hansupus@GN=A176 005453 tr|A0A1I3SZX4|A0A1I3SZX4 9FIRM@Lar N domain-containing protein@OS=Ruminococcaceae bacterium D5@GN=SAMN02910435 02493 tr|A0A0D8HJ30|A0A0D8HJ30 9ACTN@Lar N domain-containing protein@OS=Acidithrix ferrooxidans@GN=AXFE 20140 tr|F4LXK7|F4LXK7 TEPAE@Lar N domain-containingtr|A0A1M5A682|A0A1M5A682 protein@OS=Tepidanaerobacter 9FIRM@Nickel-dependent acetatoxydans lactate strain racemase@OS=Alkalibacter DSM 21804 / JCM 16047 saccharofermentans / Re1@GN=TEPIRE1 DSM 14828@GN=SAMN02746064 1945 02237 tr|A0A142X8F2|A0A142X8F2 9BACT@Lar N domain-containing protein@OS=Gemmata sp. SH-PL17@GN=VT84 02765 tr|A0A0C2D3T0|A0A0C2D3T0 9DELT@Transcriptional regulator@OS=Enhygromyxa salina@GN=DB30 02504

tr|A0A1J4MYW7|A0A1J4MYW7 9ACTN@Transcriptional regulator@OS=Nocardioides luteus@GN=UG56 025790 tr|D2RN64|D2RN64 ACIFV@Lar N domain-containing protein@OS=Acidaminococcustr|A0A1G5RVP9|A0A1G5RVP9 9FIRM@Lar fermentans N domain-containing strain ATCC protein@OS=Acidaminobacter 25085 / DSM 20731 / VR4@GN=Acfer hydrogenoformans DSM 0081 2784@GN=SAMN03080599 01148 tr|A0A0T6LWM2|A0A0T6LWM2tr|A0A0F7MYH9|A0A0F7MYH9 9ACTN@Transcriptional 9ACTN@Transcriptional regulator@OS=Streptomyces regulator@OS=Streptomyces vitaminophilus@GN=AQ490 sp. CNQ-509@GN=AA958 1564502840 tr|A0A0S9Q4B8|A0A0S9Q4B8 9ACTN@Transcriptionaltr|A0A023X4B4|A0A023X4B4 regulator@OS=Nocardioides 9ACTN@Lar N domain-containing sp. Leaf285@GN=ASF47 protein@OS=Rubrobacter radiotolerans@GN=RradSPS 12455 1895 tr|A0A1P8WP23|A0A1P8WP23 9PLAN@Lar N domain-containing protein@OS=Fuerstia marisgermanicae@GN=Fuma 05457tr|A0A0Q7AVG1|A0A0Q7AVG1 9ACTN@Transcriptional regulator@OS=Nocardioides sp. Root1257@GN=ASC77 21770

tr|A6FY50|A6FY50 9DELT@Lar N domain-containing protein@OS=Plesiocystis pacifica SIR-1@GN=PPSIR1 39600 tr|A0A1M6M4W5|A0A1M6M4W5 9FIRM@Lar N domain-containing protein@OS=Dethiosulfatibacter aminovorans DSM 17477@GN=SAMN02745751 03359

tr|A0A250IK06|A0A250IK06tr|A0A1F3BYX9|A0A1F3BYX9 9DELT@Transcriptional 9DELT@Transcriptional regulator@OS=Melittangium regulator@OS=Anaeromyxobacter boletus DSM 14713@GN=MEBOL sp. RBG 16 69 14@GN=A2V77 005081 20515

tr|Q1DC42|Q1DC42 MYXXD@Lar N domain-containing protein@OS=Myxococcus xanthus strain DK 1622@GN=MXAN 1529 tr|A0A1V1W918|A0A1V1W918 9ACTN@Lar N domain-containing protein@OS=Nocardioidestr|A7H9M5|A7H9M5 ANADF@Lar sp. PD653@GN=PD653 N domain-containing protein@OS=Anaeromyxobacter 4263 sp. strain Fw109-5@GN=Anae109 1213 tr|F5Y6T0|F5Y6T0 TREAZ@Iron-sulfur cluster-binding protein@OS=Treponema azotonutricium strain ATCC BAA-888 / DSM 13862 / ZAS-9@GN=TREAZ 1189 tr|F8B571|F8B571 FRADG@Lar N domain-containingtr|A0A239IG81|A0A239IG81 protein@OS=Frankia 9ACTN@Lar N domain-containing symbiont protein@OS=Actinomadurasubsp. Datisca glomerata@GN=FsymDg meyerae@GN=SAMN05443665 2368 1012124 tr|A0A142WV39|A0A142WV39 9PLAN@Lar N domain-containing protein@OS=Planctomyces sp. SH-PL14@GN=VT03 11275 tr|A9FNW2|A9FNW2 SORC5@Lar N domain-containing protein@OS=Sorangium cellulosum strain So ce56@GN=sce8293

tr|A0A1M3NH59|A0A1M3NH59 9DELT@Transcriptional regulator@OS=Myxococcales bacterium 68-20@GN=BGO98 28540

tr|A0A2E7UW30|A0A2E7UW30 9DELT@Transcriptional regulator@OS=Deltaproteobacteria bacterium@GN=CL927 18360 tr|A0A1U7GFJ8|A0A1U7GFJ8 9BACT@Lar N domain-containing protein@OS=Planctomycetales bacterium 71-10@GN=BGO49 29605 tr|E3FDM8|E3FDM8 STIAD@Conserved uncharacterizedtr|A0A017TBH3|A0A017TBH3 protein@OS=Stigmatella 9DELT@Transcriptional regulator@OS=Chondromycesaurantiaca strain DW4/3-1@GN=STAUR apiculatus DSM 436@GN=CAP 2303 1689 tr|U1GPL3|U1GPL3tr|F5YGA3|F5YGA3 TRESO@PF09861 TREAZ@Iron-sulfur family cluster-binding protein@OS=Treponema protein@OS=Treponema socranskii subsp. azotonutricium socranskii strain VPI ATCCDR56BR1116 BAA-888 = ATCC/ DSM 35536@GN=HMPREF132513862 / ZAS-9@GN=TREAZ 0536 3637 tr|S4XQV3|S4XQV3 SORCE@Lar N domain-containing protein@OS=Sorangium cellulosum So0157-2@GN=SCE1572 48395 tr|E1RB52|E1RB52 SEDSS@Lar N domain-containing protein@OS=Sediminispirochaeta smaragdinae strain DSM 11293 / JCM 15392 / SEBR 4228@GN=Spirs 0433 tr|F2N8Q6|F2N8Q6 CORGP@Lar N domain-containing protein@OS=Coriobacterium glomerans strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2@GN=Corgl 1338 tr|Q2IQ59|Q2IQ59ANADE@Lar N tr|A0A0K1E7F1|A0A0K1E7F1domain-containing protein@OS=Anaeromyxobacter CHOCO@Lar N domain-containing dehalogenansprotein@OS=Chondromyces strain 2CP-C@GN=Adeh crocatus@GN=CMC5 1166 006190

tr|Q0RJB2|Q0RJB2 FRAAA@Lar N domain-containing protein@OS=Frankia alni strain ACN14a@GN=FRAAL3757 tr|A0A1F9FGX9|A0A1F9FGX9 9DELT@Transcriptional regulator@OS=Deltaproteobacteria bacterium RBG 16 71 12@GN=A2138 25355 tr|A1SI75|A1SI75tr|A0A1A9GRN5|A0A1A9GRN5 NOCSJ@Lar N domain-containing 9ACTN@Lar N domain-containing protein@OS=Nocardioides protein@OS=Nocardioidestr|A0A1H7GB75|A0A1H7GB75 sp. strain ATCCSTIAU@Lar BAA-499dokdonensis N domain-containing / JS614@GN=Noca FR1436@GN=I601 protein@OS=Stigmatella 2000 aurantiaca@GN=SAMN05444354 3706 101362

tr|A0A1C3P0H3|A0A1C3P0H3 9ACTN@Lar N domain-containing protein@OS=Candidatus Frankia californiensis@GN=FDG2 3717 tr|A0A1H1X3B0|A0A1H1X3B0 9ACTN@Lar N domain-containing protein@OS=Actinopolymorpha singaporensis@GN=SAMN04489717 4787 tr|A0A0J0V0G9|A0A0J0V0G9 9ACTN@Lar N domain-containing protein@OS=Actinobacteriatr|A0A0B6WWR0|A0A0B6WWR0 9BACT@Lar bacterium N domain-containing IMCC26207@GN=IMCC26207 protein@OS=Pyrinomonas methylaliphatogenes@GN=PYK22 10226 00719

tr|A0A0D8FUL5|A0A0D8FUL5 9ACTN@Lar N domain-containing protein@OS=Ferrimicrobium acidiphilum DSM 19497@GN=FEAC 14380

tr|Q1AU77|Q1AU77 RUBXD@Lar N domain-containing protein@OS=Rubrobacter xylanophilus strain DSM 9941 / NBRC 16129@GN=Rxyl 2107

tr|G7WI98|G7WI98 DESOD@Lar N domain-containing protein@OS=Desulfosporosinus orientis strain ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628@GN=Desor 3024 tr|A0A1M7PN86|A0A1M7PN86 9ACTN@Lar N domain-containing protein@OS=Streptomyces paucisporeus@GN=SAMN05216499 12479 tr|M5S139|M5S139 9BACT@Lar N domain-containing protein@OS=Rhodopirellula maiorica SM1@GN=RMSM 01700 tr|A0A1G7BW98|A0A1G7BW98 9ACTN@Lar N domain-containing protein@OS=Nocardioides lianchengensis@GN=SAMN05421872 11940

tr|A0A1Y4C697|A0A1Y4C697 9FIRM@Lar N domain-containing protein@OS=FlavonifractorAn306@GN=B5F88 sp. 06220

tr|A0A1Y4WDJ6|A0A1Y4WDJ6 9FIRM@Lar N domain-containing protein@OS=FlavonifractorAn10@GN=B5E42 sp. 16605 tr|A0A1I3D7G8|A0A1I3D7G8 9PLAN@Nickel-dependent lactate racemase@OS=Planctomicrobium piriforme@GN=SAMN05421753 103122

tr|A0A2A2WEG5|A0A2A2WEG5 9BACT@Lar N domain-containing protein@OS=Rhodopirellula sp. SM50@GN=CKO51tr|E3J1K0|E3J1K0 10625 FRAIE@Lar N domain-containing protein@OS=Frankia inefficax strain DSM 45817 / CECT 9037 / EuI1c@GN=FraEuI1c 3661

tr|A0A286RKU0|A0A286RKU0 9BACT@Lar N domain-containing protein@OS=Thermogutta terrifontis@GN=THTE 3957 tr|A0A1Y3UFK5|A0A1Y3UFK5tr|A0A1Y4CE51|A0A1Y4CE51 9ACTN@Lar 9ACTN@LarN domain-containing N domain-containing protein@OS=Collinsella protein@OS=Olsenella sp.An7@GN=B5G20 sp.An285@GN=B5F79 02400 10025

tr|A0A1Y4AFV9|A0A1Y4AFV9 9ACTN@Lar N domain-containing protein@OS=Collinsella sp.An307@GN=B5F89 03840

tr|D2Q1W5|D2Q1W5 KRIFD@Lar N domain-containing protein@OS=Kribbella flavida strain DSM 17836 / JCM 10339 / NBRC 14399@GN=Kfla 3040

tr|A0A1Y4HSB5|A0A1Y4HSB5 9FIRM@Lar N domain-containing protein@OS=AnaeromassilibacillusAn200@GN=B5F35 sp. 13550 tr|B6GA07|B6GA07 9ACTN@Lar N domain-containing protein@OS=Collinsella stercoris DSM 13279@GN=COLSTE 00898 tr|A0A0C5G8N8|A0A0C5G8N8 9ACTN@Transcriptional regulator@OS=Streptomyces cyaneogriseus subsp. noncyanogenus@GN=TU94 27840 tr|A0A1Y3WS42|A0A1Y3WS42An52@GN=B5G06 9FIRM@Lar 13735 N domain-containing protein Fragment@OS=Flavonifractor sp.

tr|G8QWU7|G8QWU7 SPHPG@Uncharacterized conserved protein DUF2088@OS=Sphaerochaeta pleomorpha strain ATCC BAA-1885 / DSM 22778 / Grapes@GN=SpiGrapes 0540 tr|A0A1M4WUG3|A0A1M4WUG3 9ACTN@Lar N domain-containing protein@OS=Ferrithrix thermotolerans DSM 19514@GN=SAMN02745225 01793 tr|C6LGN3|C6LGN3 9FIRM@Lar N domain-containing protein@OS=Marvinbryantia formatexigens DSM 14469@GN=BRYFOR 07793 tr|L0DK69|L0DK69 SINAD@Lar N domain-containing protein@OS=Singulisphaera acidiphila strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10@GN=Sinac 5083 tr|D0LX89|D0LX89 HALO1@Lar N domain-containing protein@OS=Haliangium ochraceum strain DSM 14365 / JCM 11303 / SMP-2@GN=Hoch 3629

tr|L7U4B5|L7U4B5 MYXSD@Lar N domain-containing protein@OS=Myxococcus stipitatus strain DSM 14675 / JCM 12634 / Mx s8@GN=MYSTI 01656

tr|C1EGZ4|C1EGZ4 MICCC@Lar N domain-containing protein@OS=Micromonas commoda strain RCC299 / NOUM17 / CCMP2709@GN=MICPUN 64048

tr|A0A1S9C1R2|A0A1S9C1R2 9FIRM@Lar N domain-containing protein@OS=EpulopisciumAS2M-Bin002@GN=ATN32 sp. 03625

tr|A0A1I3RW40|A0A1I3RW40 9FIRM@Lar N domain-containing protein@OS=Ruminococcaceae bacterium D5@GN=SAMN02910435 02205

tr|A0A1H2A6M6|A0A1H2A6M6 9ACTN@Lar N domain-containing protein@OS=Microlunatus soli@GN=SAMN04489812 5695

tr|Q2JAP6|Q2JAP6 FRACC@Lar N domain-containing protein@OS=Frankia casuarinae strain DSM 45818 / CECT 9043 / CcI3@GN=Francci3 2278

tr|G9YNM3|G9YNM3 FLAPL@Lar N domain-containing protein Fragment@OS=Flavonifractor plautii ATCC 29863@GN=HMPREF0372 01095

tr|A0A1V2LX49|A0A1V2LX49 9FIRM@Lar N domain-containing protein@OS=Epulopiscium sp. SCG-B11WGA-EpuloA1@GN=AN396 01515

tr|C7M046|C7M046ACIFD@Lar N domain-containing protein@OS=Acidimicrobium ferrooxidans strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP@GN=Afer 1430

tr|A0A0P9EDR7|A0A0P9EDR7 9ARCH@Lar N domain-containing protein@OS=Candidatus Bathyarchaeota archaeon BA1@GN=AOA65 0533

tr|A0A255HBD5|A0A255HBD5 9ACTN@Transcriptional regulator@OS=Propionibacteriaceae bacterium NML 130396@GN=CGZ93tr|H8MWW2|H8MWW2 CORCM@Lar N domain-containing 04275 protein@OS=Corallococcus coralloides strainATCC 25202 / DSM 2259 / NBRC 100086 / M2@GN=COCOR 01539 tr|F0SIA3|F0SIA3 RUBBR@Lar N domain-containing protein@OS=Rubinisphaera brasiliensis strain ATCC 49424 / DSM 5305 / JCM 21570 / NBRC 103401 / IFAM 1448@GN=Plabr 0869 tr|A0A1I3JXT1|A0A1I3JXT1 9FIRM@Lar N domain-containing protein@OS=Ruminococcaceae bacterium D5@GN=SAMN02910435 00485 tr|D5SP13|D5SP13 PLAL2@Lar N domain-containing protein@OS=Planctopirus limnophila strain ATCC 43296 / DSM 3776 / IFAM 1008 / 290@GN=Plim 0317 tr|A0A1G7B7E5|A0A1G7B7E5tr|A0A255GEG8|A0A255GEG8 9ACTN@Lar 9ACTN@Transcriptional N domain-containing regulator@OS=Propionibacteriaceae protein@OS=Auraticoccus monumenti@GN=SAMN04489747 bacterium NML 030167@GN=CGZ94 2865 06295

tr|A0A1G6GT84|A0A1G6GT84 9ACTN@Lar N domain-containing protein@OS=Raineyella antarctica@GN=GA0111570 10518

tr|A0A1Q2CED0|A0A1Q2CED0 9ACTN@Lar N domain-containing protein@OS=Tessaracoccus flavus@GN=RPIT 06350 tr|A0A1R1IKA4|A0A1R1IKA4 9ACTN@Lar N domain-containing protein@OS=Tessaracoccus sp. ZS01@GN=BJN44 02885

tr|A0A1Q2D112|A0A1Q2D112 9ACTN@Lar N domain-containing protein@OS=Tessaracoccus flavescens@GN=BW733 16195

tr|A0A1C0AMW3|A0A1C0AMW3tr|A0A1G9MAE2|A0A1G9MAE2 9ACTN@Lar 9ACTN@Lar N domain-containing N domain-containing protein@OS=Tessaracoccus protein@OS=Tessaracoccus lapidicaptus@GN=BCR15 oleiagri@GN=SAMN04488242 02975 2489

tr|A0A1Q2CM26|A0A1Q2CM26 9ACTN@Lar N domain-containing protein@OS=Tessaracoccus aquimaris@GN=BW730 06250

tr|A0A1M6CLK8|A0A1M6CLK8 9ACTN@Lar N domain-containing protein@OS=Tessaracoccus bendigoensis DSM 12906@GN=SAMN02745244 00702

tr|I6XRR9|I6XRR9 PSEPQ@Lar N domain-containing protein@OS=Pseudopropionibacterium propionicum strain F0230a@GN=HMPREF9154 1657

tr|F5XJF8|F5XJF8 MICPN@Lar N domain-containing protein@OS=Microlunatus phosphovorus strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1@GN=MLP 28440

Figure S6