Rates of Herbivory on Different Tropical Trees
Tut Journal or Biologjcal Chkmistry Vol. 270, No. 28, 19-9UG of July 14, pp. 16796-16802. 1995 £> 1995 by The American Society for Biochemistry and Mnlccutar Biology, Inc. Printed in USA- A N ew Fam ily of C onotoxins T hat Blocks V oltage-gated Sodium Channels* (Received for publication, March 23, 1995, and in revised form, May 8 , 1995) J. Michael McIntoshtSU, Arik Hasson, Micha E. Spiral, William R, GrayS, Wenqin Li§, Maren Marsh**, David R. HillyardS**, and Baldomero M. Olivera § From the Departments of ^Biology, **Pathology, and tPsychiatry, University of Utah, Salt Lake City, Utah., 84112, the IIDepartment of Neurabiology, Institu te of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel, and The Interuniversity Institute for Marine Science*, Eilat SSI03, Israel Conus peptides, including o>-conatoxins a n d ct-cono- subtypes. For example, in the calcium channel field, the £Q toxins (targeting calcium channels and nicotinic acetyl <u-conotoxins have provided the means for discriminating be choline receptors, respectively) have been useful li tween various channel subtypes that play a role in neurotrans gands in neuroscience. In this report, we describe a ne w mitter reiease (see Ref. 1 for review). m family of sodium channel ligands, the /iO-conotoxins. Conus peptides that target voltage-sensitive sodium chan The two peptides characterized, (xO-conotoxins MrVIA nels have also been described. The best characterized of these < a n d M r V I B f r o m Conus marmoreus potently block the are the (i-conotoxins, which selectively target vertebrate skel Downloaded from sodium conductance in Aplysia neurons.
[Show full text]