Authors: J. Michael Cherry Eurie Hong Benjamin Vincent Cynthia Krieger An online version of this diagram is available through BioCyc.org and may be used for analysis of omics datasets. Lines in the diagram correspond to reactions; nodes correspond to metabolites. Rama Balakrishnan Ron Caspi Pathways are colored according to their cellular function, such as biosynthesis of cofactors. YeastCyc: Saccharomyces cerevisiae S288c Cellular Overview Reactions not assigned to any pathway are in the far right of the cytoplasm. Julie Park Hartmut Foerster In the membrane are transporters (with arrows) and other membrane proteins. H + H + cys spermidine glu quinidine taurocholate a glutathione- a glutathione- connections between pathways are omitted for legibility. FAD FAD 4-aminobutanoate lactate SAM urea glutamate H + H + S-methyl-L- 1-(β-D ribofuranosyl)nicotinamide allantoate (R)- spermidine spermidine putrescine serine glutamate ser lys lys lys met met SAM a glutathione-S-conjugate S-conjugate S-conjugate thiamine thiamine pyridoxine riboflavin putrescine spermidine selenite putrescine spermidine asp NADH UDP-α-D- glutathione glutathione a sterol a sterol methionine thiamine N-carbamoyl-L-aspartate uracil pantothenate putrescine putrescine asp ketoconazole uridine 5-aminolevulinate pyruvate putrescine galactose [+ 2 more] vacuolar mitochondrial proton proton- YDL019C STErile YOR071C YOR192C YLR237W YJR152W YFR012W YBR021W YGL186C YBR078W YGR198W YGR289C YOR306C YPL221W YAL053W YBR132C YHR073W YIL047C YDL210W YBR264C YKL073W YDR046C YCL025C YKR055W YLR004C YCR028C YLR194C YLR262C YLR353W YLR422W YML003W YMR017W YMR063W YMR212C YMR266W YNL098C YNL275W YPL274W YCL069W YKL217W YPL274W YOR273C YLL028W YKL174C YHL016C YOR161C YPL265W YNL065W YER119C YCR017C YPR173C YNL055C YPL279C YPL158C GPB1 YOR327C YOR104W YOR049C YOR018W YOL084W YOL019W YNR055C YNL318C YNL194C YNL047C SFXN1 YPL244C YBR147W YCL038C YNL268W YHL036W YGR055W YBL042C YNL003C YKR106W YLL048C YDR135C YLL015W YCL073C YJL214W YIR039C YIL013C YOR011W translocating transporting YPL036W YGL008C YLL061W YGR086C YGL160W YFL047W YER155C YER020W YDR459C YDR309C YDL222C YAL030W GPB2 YAR023C YAR027W YAR028W YAR029W YAR031W YAR050W YAR066W YBL060W SKT5 YBL069W YBL075C YBL106C YBR016W YBR043C YBR052C YBR054W ATPase ATP synthase complex complex YBR080C YBR068C spermidine quinidine α taurocholate a glutathione- a glutathione- 1-(β-D ribofuranosyl)nicotinamide FAD FAD 4-aminobutanoate lactate urea UDP- -D- H + H + allantoate uracil cys (R)- spermidine spermidine putrescine glu glutamate uridine a glutathione-S-conjugate S-conjugate S-conjugate thiamine thiamine thiamine pyridoxine riboflavin putrescine spermidine selenite SAM spermidine glutamate NADH galactose glutathione glutathione a sterol a sterol S-methyl-L- N-carbamoyl-L-aspartate pantothenate putrescine putrescine serine ketoconazole ser lys lys lys met met SAM 5-aminolevulinate pyruvate putrescine putrescine asp H + H + methionine asp [+ 2 more]

YBR293W YBR219C

YMR305C YCR007C

Tetrapyrrole Metabolic Biosynthesis YCL048W Regulator a 5’-(N 7 -methyl 5’- Man 9 GlcNAc 2 - Biosynthesis a 1-arachidonoyl- quinoxaline-2- triphosphoguanosine)- 2-(glutathion-S-yl) [protein] (isomer phosphoenol a nucleoside a mRNA with (2R,3S)-2- sn-glycerol iron-sulfur cluster Cofactor, Carrier, and Vitamin Biosynthesis siroheme Nucleoside and Nucleotide Degradation YGR279C YCL048W-A flavin biosynthesis ubiquinol-6 biosynthesis from γ glutathione- Metabolic Clusters Ac/N-end rule pathway aryl-carrier protein carboxyl adenylate (purine-ribonucleotide) -2-carboxypropane RNA 2-acyl-sn-glycerol poly(A) tail methylisocitrate 5’Ap3A biosynthesis superpathway of tetrahydrofolate superpathway of ubiquinol- 4-amino-2-methyl-5- NAD de novo -glutamyl cycle folate interconversions thioredoxin biosynthesis fructose 2,6- ATP 9A 1,2,3 B 1,2,3 ) dGDP pyruvate triphosphate AMP GTP ADP ATP ATP 3-phosphate ITP III (fungi) 4-hydroxybenzoate (eukaryotic) glutaredoxin Aromatic Compound Biosynthesis a tRNA precursor -[mRNA] 3-phosphatephosphatidate glycerol-3- biosynthesis and salvage 6 biosynthesis (eukaryotic) phosphomethylpyrimidine biosynthesis II system bisphosphate an N-terminal- biotin phosphate 1-O- biosynthesis (from tryptophan) redox reactions biosynthesis an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- an N-terminal- purine ribonucleosides degradation CTP phosphatase: PAH1 L-methionyl-L- glutathione DNA-directed poly(A)-specific L-cysteine uroporphyrinogen-III L-methionyl-L- L-methionyl-L- L-methionyl- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- L-methionyl-L- UTP and CTP 5’-(N(7)-methyl 5’- phosphatidate acyltransferase: ITP diphosphatase: all-trans-hexaprenyl glutathione a 5-methyltetrahydrofolate chorismate N-terminal L- phenylalanyl- UTP and CTP dephosphorylation I peptide:N- ribonuclease: desulfurase all-trans-hexaprenyl an oxidized methionine methionine methionine methionine methionine methionine N-terminal N-terminal N-terminal N-terminal N-terminal L- N-terminal L- N-terminal L- N-terminal L- dephosphorylation II triphosphoguanosine)- S-conjugate RNA polymerase: phosphatase: LPP1 IsoCitrate SCT1 bis(5’-adenosyl) 4-aminobenzoate PRPP 4-hydroxybenzoate glutathione uroporphyrinogen-III 4-hydroxybenzoate β-D-fructose alanyl-[protein] cysteinyl-[protein] glycyl-[protein] seryl-[protein] threonyl-[protein] valyl-[protein] asparaginyl-[protein] glutaminyl-[protein] aspartyl-[protein] glutamyl-[protein] leucyl-[protein] isoleucyl-[protein] tryptophyl-[protein] tyrosyl-[protein] glycanase: PNG1 bifunctional glycerol-3- NPP1 YCR024C-A GTP diphosphate GTP diphosphate thioredoxin biosynthesis p-aminobenzoate methionine N α- α- methionine N α- methionine N α- methionine N α- methionine N α- [protein]methionine N α- methionine N α- methionine N α- acyl carrier carboxypeptidase: pyruvate RPB10 RPA43 ATP CAF130 CCR4 Lyase: ICL2 -triphosphatase: trp C-methyltransferase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: methionine N CCA tRNA (mRNA) diphosphatase: nucleoside- diacylglycerol biotin--[acetyl- [+ 2 isozymes] alpha factor epsin biosynthesis biosynthesis 2,6-bisphosphate acetyltransferase: acetyltransferase: acetyltransferase: acetyltransferase: acetyltransferase: protein: ACP1 adenylyltransferase: MOT2 NOT5 POP2 phosphate-O- L-cysteine gamma- methylenetetrahydrofolate reductase: MET12 MAP2 MAP2 MAP2 MAP2 MAP2 MAP2 acetyltransferase: acetyltransferase: acetyltransferase: acetyltransferase: UTP UTP nucleotidyltransferase: DCS2 DCS1 ATG42glutathione kinase: PYK2 RPA12 RPA49 phosphate CoA-carboxylase] HNT2 MET1 I (eukaryotes) methionine methionine methionine methionine methionine methionine α adenosine 5’-(N 7 -methyl 5’- α pyruvate diphosphate acyltransferase: phosphoribosylpyrophosphate tryptophan 2,3- glutathione methylenetetrahydrofolate reductase: MET13 phosphoenol NAT2 NAT2 NAT2 NAT2 MAK31 MAK31 an N-terminalMAK31 N - an N-terminalMAK31 MAK31 -D-Man-(1->2)- RPO26 RPB5 APA1 CAF40 CDC39 desulfurase: 4-aminobenzoate:hexaprenyl- para-hydroxybenzoate:hexaprenyl- glutamyltransferase: precorrin-1 N-terminal N-terminal N-terminal N-terminal an N-terminal N α- an N-terminal N α- an N-terminal N α- CCA1 triphosphoguanosine) S-conjugate kinase: ADK2 phosphatase/ 5’,5’’’-P-1,P-4- ligase: BPL1 1-C16:0-α,ω- dioxygenase: BNA2 pyruvate3-deoxy-D-arabine- aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: aminopeptidase: MAK10 MAK3 MAK10 MAK3 acetyl-L-methionyl-MAK10 MAK3 N α-acetyl-L-MAK10 MAK3 MAK10 MAK3 α-D-Man-(1->2)-α- kinase: CDC19 NOT3Poly(A)- CDC36 GPT2 IMP diphosphate amidotransferase: ADE4 GTP cyclohydrolase diphosphate synthetase: GSH2 ECM38 bifunctional methionine N α α nucleoside- UTP phosphatase: carboxypeptidase: RPB8 RPA135 tetraphosphate NFS1 ISD11 GTP-cyclohydrolase a reduced thioredoxin-disulfide chorismate MAP1 MAP1 MAP1 MAP1 MAP1 MAP1 - methionine N - methionine N α- methionine N α-acetyl-L-methionyl- acetyl-L-methionyl- acetyl-L-methionyl- CTP synthase: URA8 CTP synthase: -[mRNA] α a [protein]- phosphatidate dicarboxyl-2- N-Formyl- heptulosonate- tyr an N-terminal L- an N-terminal L- an N-terminal an N-terminal an N-terminal L- an N-terminal L-phenylalanyl- methionyl-L- D-Man-(1->3)-[ - RPA14 RPC10 binding protein- I: FOL2 hexaprenyltransferase: COQ2 II: RIB1 hexaprenyltransferase: COQ2 fructose-2,6- an N-terminal-acetyltransferase:N α acetyltransferase: triphosphatase: FAP7 CTP synthase: URA7 YND1 URA8 PRC1 phosphorylase pyruvate succinate an S-sulfanyl- glutaredoxin reductase: TRR2 precorrin-1 C- L-tyrosine:2- YLR345W: L-seryl-[protein] - an N-terminal acetyltransferase: acetyltransferase: L-leucyl-[protein] L-isoleucyl-[protein] L-tyrosyl-[protein] a quinoxaline-2- diphosphatase: DCS1 α L-aspartate phosphatase: DPP1 lysophosphatidate 5-phospho-β- L-kynurenine 2,5-diamino-6- thiamin formation from a 5,10-methylenetetrahydrofolate 7-phosphate aminodeoxychorismate alanyl-[protein] cysteinyl-[protein] glycyl-[protein] threonyl-[protein] L-valyl-[protein] an N-terminal-N α- an N-terminal N α- [protein] tryptophyl-[protein] adenosine UTP phosphatase: YND1 CTP synthase: D-Man-(1->2)- - RPC19 RPA190 phosphatidate dependent poly(A) [L-cysteine superpathway methylenetetrahydrofolate thioredoxin-disulfide methyltransferase: bisphosphate 2- YLR345W acetyl-L-methionyl-MDM20 NAT3 N α-acetyl-L-MDM20 NAT3 MDM20 NAT3 MDM20 NAT3 carboxyl-[aryl- II: APA2 ADP AMP YDR089W all-trans-hexaprenyl arylformamidase: pyrithiamine and oxythiamine synthase: ARO3 oxoglutarate synthase: ABZ1 N-terminal N-terminal deaminase: AAH1 a tRNA containing AMP D-Man-(1->3)-[α- phosphatase: APP1 biotinyl-5’-adenylate riboNuclease: YPL130W D-ribosylamine (5-phospho-D- 3-hexaprenyl-4- thymidylate synthase: CDC21 monothiol reductase: TRR1 3-deoxy-7- phosphatase/6- fructose-2,6- N-terminal alanine N N-terminal glycine N N-terminal serine N N-terminal valine N acetyl-L-methionyl- acetyl-L-methionyl- CTP URA7 γ pyruvate RPA34[+ 3 isozymes] RPC40 a 1-arachidonoyl- YDL072C desulfurase] 7,8-dihydroneopterin 4-hydroxybenzoate diphosphate 3-all trans-hexaprenyl- of heme b dehydrogenase (NADP + ): ADE3 MET1 L-asparaginyl- methionyl-L- UMP carrier protein] -L-glutamyl-(S)- α BNA3 aminotransferase: 4-amino-4- bisphosphatase: cysteine N α- threonine N α- L-aspartyl-[protein] L-glutamyl-[protein] UDP a 3’ CCA end a diphospho-5’- D-Man-(1->2)- - dGTP ADP GDP PAN2 PAN3 4-aminobenzoate ribosylamino) hydroxybenzoate NAD-dependent methylenetetrahydrofolate5,10- glutaredoxin: GRX3 phosphoheptulonate phosphofructo-2- α-acetyltransferase: α-acetyltransferase: α-acetyltransferase: α-acetyltransferase: [protein] glutaminyl-[protein] N 7 -methylguanosine 2-carboxypropyl- 2-acyl-sn-glycerol ISU1 scaffold 3’-triphosphate Arylformamidase: biosynthesis 3-(4-hydroxyphenyl)ARO8 deoxychorismate acetyltransferase: acetyltransferase: nucleoside- gly D-Man-(1->6)]-α- pyrimidin-4(3H)-one2,5-diamino-6- glycine cleavage system:methylenetetrahydrafolatedehydrogenase (NADP + ): MIS1 [+ 2 isozymes] 3-deoxy-D-arabino-synthase: ARO4 kinase: YLR345W FBP26 NAT5 ARD1 NAT1 NAT5 ARD1 NAT1 NAT5 ARD1 NAT1 NAT5 ARD1 NAT1 CTP 5’-phosphate purine-3’-[mRNA] protein: ISU1 3-hexaprenyl-4- BNA7 3-hexaprenyl-4- from glycine pyrithiamine precorrin-2 NAT5 ARD1 NAT1 NAT5 ARD1 NAT1 triphosphatase: FAP7 L-cysteine D-Man-(1->6)]-β- Ap4A para-hydroxybenzoate:hexaprenyl- pyruvate [+ 2 isozymes] inosine guanosine ISU2 scaffold (ribosylamino)- GCV3 GCV1 GCV2 LPD1dehydrogenase: MTD1 a protein with heptulosonate an N-terminal an N-terminal an N-terminal an N-terminal an N-terminal an N-terminal Macromolecule UTP phosphatase: YND1 CTP diphosphatase: YND1 RNA aminobenzoate hydroxybenzoate aminodeoxychorismate xanthosine adenosine CTP diphosphatase: D-Man-(1->4)-β-D- an mRNA an S-sulfanyl- diphosphate 4(3H)-pyrimidinone a reduced N-acetyl-L- α N α α N α α protein: ISU2 L-kynurenine monooxygenase: COQ6 gly reduced L- precorrin-2 7-phosphate N -acetyl-L- -acetyl- N -acetyl-L- -acetyl-L- N -acetyl-L- Modification α AMP hexaprenyltransferase: COQ2 monooxygenase: COQ6 γ-L-glutamyl- cys gly α γ thioredoxin lyase: ABZ2 CDP YND1 GlcNAc-(1->4)- -D- YDR210W [cysteine 2’-hydroxypyridoxol 5’-phosphate an -( -L-glutamyl) thiaminase II: THI20 cysteine residues dehydrogenase: alanyl-[protein] cysteinyl-[protein] glycyl-[protein] seryl-[protein] threonyl-[protein] valyl-[protein] YOR389W 2,5-diamino-6- L-cysteine a 7,8-dihydrofolate a 5,10-methenyltetrahydrofolate 3-dehydroquinate F6P UMP glucosaminylamine desulfurase]- 3-all trans-hexaprenyl-4- reductase: RIB7 3-all trans-hexaprenyl- 5-aminolevulinate -L-amino acid MET8 tRNA splicing Degradation/Utilization/ YDR033W synthase: ARO1 inosine guanosine CMP [disordered- 7,8-dihydroneopterin 3-hexaprenyl-4- amino-5-hydroxybenzoate kynurenine 3- (5-phospho-D- 4,5-dihydroxybenzoate synthase: HEM1 trifunctional formate-tetrahydrofolate (R)-3-(4- 4-aminobenzoate CTP diphosphatase: YND1 Assimilation - Other monooxygenase: Cys-Gly 4-amino-2-methyl-5- TCA cycle TCA cycle II (plants and fungi) phosphorylase: phosphorylase: IMP 5’-nucleotidase: ISN1 form scaffold 3’-phosphate hydroxybenzoate ribitylamino) S-adenosyl-L- ligase/methenyltetrahydrofolate sirohydrochlorin hydroxyphenyl) tRNA methylation 5-aminolevulinate metallodipeptidase: pyrimidinemethanol serine hydroxymethyltransferase: SHM2 PNP1 PNP1 UMP phosphatase: PHM8 protein] complex[cysteine desulfurase]-S- 3-all trans-hexaprenyl-4- BNA4 pyrimidin-4(3H)-one2,5-diamino-6- methionine:3-hexaprenyl- glycine hydroxymethyltransferase:cyclohydrolase/methylenetetrahydrofolate SHM1 lactate 4α-methyl- a tRNA precursor 1-[18-hydroxyoeoyl]- a 1-acyl-2- 3-dehydroquinate a polycistronic CMP glutathione-mediated 1-stearoyl-2- sulfanylcysteine:[acceptor ribitylamino-4(3H) DUG1 dihydrofolate reductase: DFR1 alkylnitronates a pyrimidine base α with a 5’ extension phosphoenol 2-[18-hydroxy- arachidonoyl- YDR387C 3-hexaprenyl-4- amino-5-hydroxybenzoate 4,5-dihydroxybenzoate O- hydroxymethylpyrimidine dehydrogenase: ADE3 sirohydrochlorin tRNA precursor uridine detoxification I 5 -cholesta- H 2 O S-methyl-L- NADH carbonic acid delta- α a ferrocytochrome b 5 L-homocysteine palmitoyl-sn- 5’-phospho- a protein protein]-cysteine 3-hydroxy- -pyrimidinone gamma- methenyltetrahydrofolate cyclohydrolase: MIS1 thiamine lipoate a cytosine 40 in a cytosine 34 in a guanosine 34 a carboxymethyluridine 34 a cytidine 4 a uridine 44 an adenine 58 oxaloacetate -D-ribose- degradation lesion in DNA GTP and a short dADP pyruvate lioleoyl]-sn-glycerol ATP GTP sn-glycerol dGMP GDP YOR383C hydroxybenzoate deaminase/ pyridoxine methyltransferase: COQ3 (HMP) kinase: THI21 ferrochelatase: a cytidine 4 an adenosine 4 S-methyl-5’- 8,24-dien-3β-ol methionine L-kynurenine 3-all trans-hexaprenyl- aminolevulinate oxythiamine biosynthesis and a guanine 26 in tRNA a cytosine 49 in tRNA a cytosine 48 in tRNA a guanine 10 in tRNA guanine 37 in tRNA Phe 1-phosphate IMP 5’-nucleotidase: ISN1 phosphatidate glycerol 3-phosphatephosphatidate ribonucleotide- phosphatidate endopeptidase a [cysteinesulfurtransferase: NFS1 5’-phosphate glutamylcysteine HMP kinase: THI20 diphosphate 3-dehydroquinate tRNA precursor tRNA precursor in tRNAtRNA (cytidine 32 / in tRNAtRNA in tRNAcytidineGly 4 in tRNA Gly in tRNAtRNAser Ser in tRNA tRNA Phe 3’ extension 3-phosphate RNA 3-phosphate monooxygenase: COQ6 hydroxylase: COQ6 L-cysteinylglycine MET8 tRNA (guanine 26 -N 2 tRNA (cytosine 49 -C 5 tRNA (cytosine 48 -C 5 tRNA (cytosine 40 -C 5 tRNA (cytosine 34 -C 5 tRNA (guanine 10 -N 2 )- in tRNAcytidinePro 4 in in tRNAadenosineHis 4 in tRNA (adenine 58 -N 1 CMP phosphatase: PHM8 thioadenosine [tRNA His ] desulfurase]-S- 4-hydroxy-5- dehydratase: HEM2 synthetase: GSH1 a tetrahydrofolate an N 10 -formyltetrahydrofolate biosynthesis incorporation I dehydratase: ARO1 tRNA-splicing RX phosphatase: PAH1 phosphatase: PAH1 phosphatase: PAH1 catalytic subunit: D-erythro-7,8- D-ribulose deaminase: RIB2 guanosine 34 -2’-O)- (carboxymethyluridine 34 - (GCC) 2’-O- (uridine 44 -2’-O)- (guanine 37 -N 1 )- citrate synthase: CIT3 guanosine YDR160W 5-amino-6-(5- methoxybenzoate )-methyltransferase: )-methyltransferase: )-methyltransferase: )-methyltransferase: )-methyltransferase: monomethyltransferase: tRNA Pro 2’-O- tRNA His 2’-O- )-methyltransferase: degradation II aci-nitroethane 8-OxoGuanine phosphatidate phosphatidate phosphatidate sulfanyl-[disordered- pyridoxine 4- IV (eukaryotes) 4-coumarate endonuclease: [+ 2 isozymes] phosphoribomutase: NAD(+) carbonate IMP1 IMP2’ SOM1 dihydroneopterin chorismate 3-all trans-hexaprenyl- putative pyridoxal 5-phosphate HMP-P siroheme methyltransferase: 5-O)-methyltransferase: methyltransferase: methyltransferase: methyltransferase: cytidine Glycosylase/ ribonuclease P: AdoMet- phosphatase: LPP1 phosphatase: LPP1 phosphatase: LPP1 endopeptidase diphosphatase dehydrogenase/ kynureninase: BNA5 phospho-D- porphobilinogen thiaminase II: THI20 4-methyl-5-(2- an NTRM12 - NCL1 NCL1 NCL1 NCL1 a 2’-O- a 5-(2-methoxy- an N TRM1122 - TRM11 methyltransferase: a 2’-O- methyltransferase: a 2’-O- an NGCD101 - GCD14 an N 1 - PRM15 glutathione putative nitronate bifunctional bifunctional bifunctional dGMP kinase: GUK1 form scaffold kinase: BUD17 a 5-methylcytosine 49 a 5-methylcytosine 48 40 a 5 methylcytosine 34 TRM7 TRM9 TRM112 TRM13 TRM44 TRM5 SEN54 SEN34 S-methyl-5’- homocysteine polynucleotide diphosphatase: dehydratase: of Golgi 4,5-dihydroxybenzoate 3,4-dihydroxy- ribitylamino)uracil HMP-PP phosphooxyethyl) an octanoyl-[acp] 3-dehydroshikimate a 5 methylcytosine a 2’-OTRM13- a 2’-OTRM13- transferase: GTT2 monooxygenase: lyase: OGG1 C-4 methyl sterol putative RPM1 RPM2 pyruvate catalytic YDR522C protein] complex pyridoxine pyridoxal reductase: putative methylguanine 26 methylguanosine 34 2-oxoethyl) methylguanine 10 methylcytidine 4 in methyluridine 44 methyladenine 58 methylguanine 37 SEN15 SEN2 APurinic/ ribonuclease diacylglycerol diacylglycerol tRNA His NPY1 diacylglycerol NCE103 dihydroneopterin in tRNA in tRNA in tRNA precursor in tRNA precursor 4 4 malate dehydrogenase: MAE1 thioadenosine glutathione oxidase: ERG25 methyltransferase: adenylyltransferase: subunit: IMP2 membrane: GDA1 aminodeoxychorismate S-adenosyl-L- 2-butanone- thiazole in tRNA in tRNA methylcytidine methyladenosine in tRNA (S)-malate citrate D-ribose 5- YJR149W GTPase: LSG1 P: RPR2 POP8 kinase: PYK2 guanylyltransferase: YOR382W L-cysteine aldolase: FOL1 kinase: BUD16 YPR127W porphobilinogen phosphomethylpyrimidine formate--tetrahydrofolate ligase: MIS1 in tRNA uridine 34 in tRNA tRNAGly(GCC) in tRNA ser in tRNA Phe [+ 3 isozymes] 5’-methylthioadenosine apyrimidinic pyruvate diphosphate diphosphate AIR2 MTR4 diphosphate methionine:3-hexaprenyl- 4-phosphate 5-(2-hydroxyethyl) shikimate tRNA (N 2 - in tRNA Pro in tRNA His a 5’-half-tRNA transferase: GTT1 [+ 11 isozymes] SAM4 a peptide desulfurase: NFS1 synthase: ABZ1 3-hydroxyanthranilate kinase: THI22 formate--tetrahydrofolate ligase: ADE3 LIPoyl ligase 2: LIP2 a 3’-half-tRNA phosphate nitrite eNdonuclease: POP7 POP6 S-Methylmethionine phosphatase/ phosphatase/ THG1 phosphatase/ 2-all trans-hexaprenyl- deaminase: HEM3 hydroxymethylpyrimidine TMP dehydrogenase: methylguanine 26 -N 2 ) phosphorylase: MEU1 [+ 2 isozymes] kinase: CDC19 PAP2 HUL4 dGDP GMP an S-sulfanyl- 4,5-dihydroxybenzoate O- synthase: RIB3 glu 5-oxo-L-proline -4-methylthiazole a [lipoyl-carrier molecule with Homocysteine [+ 3 isozymes] reduced β- 6-(hydroxymethyl) 6-methoxyphenol molecule with APN1 POP1 POP5 POP4 phosphatidate phosphatidate phosphatidate methyltransferase: COQ3 pyridoxine pyridoxal 1-deoxy-L- phosphate (HMP- diphosphorylase: protein] N 6 - Hormone ARO1 -methyltransferase: a 2’,3’-cyclic aconitate hydratase: ACO1 a glutathione- 4α-carboxy- [cysteine 4-amino-4- a 5’-OH end 5-MTR-1-P RPP1 POP3 RPR1 methylTransferase: phosphatase: DPP1 phosphatase: DPP1 nicotinamide D- phosphatase: DPP1 CO 2 H 2 O YDR276C -7,8-dihydropterin 3-all trans-hexaprenyl- 3-hydroxyanthranilate glycero-tetrulose THI6 4-hydroxybenzaldehyde TRM1 aconitate hydratase: ACO2 α phosphatidate phosphatidate 5’-phospho- phosphatidate deoxychorismate 5’-phosphate ARP preuroporphyrinogen hydroxyethylthiazole P) kinase: THI21 octanoyl-L-lysine Biosynthesis phosphate end S-conjugate 5 -cholesta- H + MHT1 1-[18-hydroxyoeoyl]- AMP ribonucleotide desulfurase]-S- HMP-P an N 2 a [DNA]-3’-α,β- a ferricytochrome b 5 phosphate YER120W 4-hydroxy-5- 3,4-dioxygenase: BNA1 4-phosphate kinase: THI6 shikimate β GDP phosphatase: APP1 1-stearoyl-phosphatase: APP1 guanosine- an 1-acyl-2-phosphatase: APP1 sulfanyl-[disordered- 2-amino-4-hydroxy-6- dimethylguanine 26 fumarate hydralase: FUM1 glutathione a modified 8,24-dien-3 -ol pyruvate 2-[18-hydroxy- methoxybenzoate kinase: THI20 tetrapyrrole indole-3- a 5’-phospho-[DNA] unsaturated a tRNA precursor dATP 2-palmitoyl- RNA arachidonoyl- YOR247W hydroxymethyldihydropteridine putative pyridoxal lipoyl synthase: LIP5 tRNA ligase: TRL1 tRNA ligase: TRL1 fumarate cis-aconitate S-conjugate nucleobase linoleoyl]- ribonucleotide- form scaffold aminodeoxychorismate pyridoxine 2-amino-3- 4-methyl-5-(2- biosynthesis 4-hydroxybenzaldehyde in tRNA Other aldehyde kinase: BUD17 6,7-dimethyl-8- uroporphyrinogen thiamine phosphate acetate Activation/ with a short a tRNA fragment sn-glycerol [tRNA His ] sn-glycerol protein] complex[cysteine desulfurase]-S- pyrophosphokinase: FOL1 lyase: ABZ2 5’-phosphate carboxymuconate- phosphooxyethyl) HMP-PP shikimate dehydrogenase: HFD1 transport: YCF1 ammonium sn-glycerol pyridoxal ribityllumazine 2-all trans-hexaprenyl- III synthase: HEM4 a [lipoyl-carrier biosynthesis Respiration Inactivation/ a 5’ half-tRNA a 3’ half-tRNA glutathione 3’ extension met sulfanylcysteine:[acceptor oxidase: PDX3 6-semialdehyde thiazole kinase: ARO1 (7,8-dihydropterin- kinase: BUD16 synthase: RIB4 6-methoxyhydroquinone coenzyme A protein]-N 6 -[(R) V (bacteria malate/L- Interconversion molecule with molecule with aconitate hydratase: ACO2 S-conjugate protein]-cysteine 6-yl)methyl biosynthesis 5-oxoprolinase Digs Into Agar: DIA3 -dihydrolipoyl]- aconitate hydratase: ACO1 YFL055W 4-aminobenzoate gly and fungi) 4-hydroxybenzoate aspartate glycerol-3- a 2’ phosphate a phosphate transport: YBT1 a [cysteinesulfurtransferase: NFS1 2-all trans-hexaprenyl- 2-hexaprenyl-6-methoxy- uroporphyrinogen-III (ATP-hydrolysing) TMP [+ 3 isozymes] (indole-3-yl) 2-ketoglutarate thiamin ABC-type YDR420W diphosphate II (eukaryotic) L-lysine shikimate shuttle phosphate on its 3’ end on its 5’ end desulfurase]- 6-methoxyphenol 6,7-dimethyl-8-(1- : OXP1 diphosphorylase: dehydrogenase complex triphosphate glutathione- YOR214C 1,4-benzoquinol 5-aminolevulinate acetonitrile 3-phosphate shuttle succinate D-threo-isocitrate (S-sulfanyl) D-ribityl)lumazine (R)-4’- THI6 pathway S-conjugate a [histone H3] N 2-hydroxy-4- a 1-palmitoyl-2- 2 dihydro-6- methyltransferase: COQ5 uroporphyrinogen synthase: HEM1 a [2-oxoglutarate metabolism isocitrate dehydrogenase: IDH1 IDH2 6 6 lysine within nitrilase: NIT2 2-oxoglutarate ,N -dimethyl- an aminopeptidase a peptide with an N- oxobutane-1,2,4- (R)-lipoate a [histone]-L-lysine ADP-D-ribose isobutyl acetate -[disordered- hydroxymethylpterin 2-all-trans-hexaprenyl- decarboxylase: phosphopantothenate thiamine tRNA ligase: TRL1 Carbohydrate Degradation transporter: BPT1 oxaloacetate acyl-sn-glycerol quinolinate thiamin salvage IV [+ 2 isozymes] 3-phosphoshikimate 1- superpathway of acetoin Fermentation DHAP dehydrogenase a malonyl-[acp] a myristoyl-[acp] O-acetyl-L-serine L-allo-threonine gcv protein H histone a myristoyl-[acp] GTP dGTP form scaffold riboflavine phosphopantothenate- 5-aminolevulinate pyruvate asp thiamine succinyl-CoA ligase: LSC1 LSC2 a glutathione- L-lysine-36 ITP substrate terminal L-arginine tricarboxylate 3-phosphate pyrophosphokinase: PLP 6-methoxy-3-methyl- HEM12 β carboxyvinyltransferase: and butanediol biosynthesis E2 protein] N 6 - alpha-ketoglutarate phosphatidate acetyltransferase: quinolinate synthetase: RIB5 thiamine phosphate thiamine 4-methyl-5( - (indol-3-yl)acetate aspartate YFL011W protein] complex FOL1 1,4-benzoquinol cysteine ligase: CAB2 ARO1 fermentation lipoyl-L-lysine dehydrogenase: diphosphate S-conjugate phosphatase: PAH1 TRA1 SPT7 TAF5 phosphoribosyl (R)-4’- hydroxyethyl) 4-hydroxyphenylpyruvate aminotransferase: D-galactose degradation V (Leloir pathway) bifunctional 4- enoyl-[acyl- 2-all trans-hexaprenyl- coproporphyrinogen III delta- pyrophosphokinase: to (R)-acetoin I dihydrolipoamide NADH repair a 2’-phospho- glutathione [histone-H3]- phosphatidate dGTP frataxin: YFH1 5-demethoxyubiquinol phosphopantothenoyl- thiazole salvage 5-enolpyruvoyl- biosynthesis AAT2 KGD1 sucrose degradation III fructose hydroxy-4-methyl- putative NGG1 GCN5 carrier-protein] GTP diphosphatase: transferase thiamine aminolevulinate THI80 pyruvate dimethyl-L- bifunctional cysteine synthase/ putative arginine/alanine isobut acetate diphosphatase: YDR463W YOR010C 6-methoxyhydroquinone riboflavin phosphopantothenate shikimate aspartate glycerol 3- dehydrogenase: [ligated tRNA] succinyl-CoA 2-oxoglutarate degradation S-conjugate lipoate--protein bifunctionalphosphatase: LPP1 SPT3 TAF6 HFI1 YSA1: YSA1 NPP1 7,8-dihydropteroate (decarboxylating) hydroxylase: COQ7 L-cysteine dehydratase: HEM2 glycerol-3- 3-oxohexanoyl-[acp] O-acetylhomoserine aminopeptidase: aminopeptidase: L-allo-threonine 2-oxoglutarate reductase: ETR1 NPP1 biosynthesis I 5-(2-hydroxyethyl) pyruvate aminotransferase: phosphate LPD1 β γ-glutamate lysine-36 esterase: IAH1 [+ 2 isozymes] a [cysteine 2-hexaprenyl-6-methoxy- coproporphyrinogen thiamine 3-phosphate phosphate a [2-oxoglutarate a [2-oxoglutarate -D-galactopyranose aldolase/ ligase: AIM22 diacylglycerol TAF12 SPT20 [+ 2 isozymes] : BNA6 -4-methylthiazole NADH tRNA 2’- hydrolase: ECM38 demethylase: GIS1 synthase: CEM1 aminocarboxypropyltransferase: phosphoenolpyruvate YDR415C AAP1 aldolase: GLY1 desulfurase]- an [HMP-P phosphopantothenoylcysteine tyr AAT1 dehydrogenase: dehydrogenase dehydrogenase thiamine sucrose β [histone H3]- bifunctional vacuolar diphosphate ADA2 CHD1 a (2E)-tetradec- a 5,10- 1,4-benzoquinol riboflavin oxidase: HEM13 porphobilinogen diphosphate pyruvate carboxy- acetolactate oxaloacetate dehydrogenase: -D-fructofuranose an (L- MET17 carboxykinase: PCK1 oxaloacetate heme a NaMN 3-demethylubiquinol-6 decarboxylase: CAB3 VHS3 SIS2 thiaminase II: THI20 3-methyl-2- hydroxyethylthiazole chorismate L-tyrosine:2- GPD1 diphosphate kinase phosphotransferase: phosphatase/ YGL108C [scaffold protein- dihydrofolate methyltransferase: COQ5 synthase]-(PLP- GUT2 [+ 2 isozymes] E2 protein] N 6 E2 protein] N 6 -S- galactose cysteinylglycine) lysine-36 cysteine synthase: MCY1 aminopeptidase/ aminopeptidase decarboxylase: a [glycine- SGF73 TAF10 2-enoyl-[acp] methenyltetrahydrofolate kinase: FMN1 kinase: THI6 lyase: PDC6 synthase: ILV2 ILV6 TPT1 2-ketoglutarate dehydrogenase GMP dGMP (2Fe-2S)] complex synthase: FOL3 2-all-trans-hexaprenyl- biosynthesis S-adenosyl-L- oxobutanoate synthase: ARO2 oxoglutarate pyruvate malate fructokinase: HXK2 demethylase: JHD1 epoxide ysc1: APE1 phosphatidate TAF9 RTG2 UBP8 D-ribofuranose trifunctional formate- imine)-L-lysine nicotinate nucleotide 4-methyl-5-(2- -dihydrolipoyl- succinyldihydrolipoyl- complex: LPD1 KGD1 KGD2 YMR31 mutarotase: GAL10 -S-conjugate YER010C cleavage complex [+ 9 isozymes] protoporphyrinogen IX porphobilinogen aminotransferase: pyruvate fructokinase: HXK1 a [histone]-N 6 - 5-phosphate acetate isobutanol YOR009W 6-methoxy-3-methyl- 4-amino-2-methyl-5- methionine:2- 4’-phosphopantetheine 3-methyl-2-oxobutanoate decarboxylase: (S)-2-acetolactate dehydrogenase: L-lysine L-lysine invertase: SUC2 hydrolase: LAP2 H protein] N 6 -[(R phosphatase: DPP1 AMP JAC1 co- tetrahydrofolate ligase/ adenylyltransferase: 4-amino-2-methyl-5- 5-(2-hydroxyethyl) phosphooxyethyl) 3-(4-hydroxyphenyl) Appr>p tRNA-uridine 2-thiolation (cytoplasmic) a 3-oxohexadecanoyl- acetaldehyde phosphatidate 7,8-dihydrofolate 1,4-benzoquinol FMN hexaprenyl-3-methyl- deaminase: HEM3 superpathway of lipoate biosynthesis ARO8 decarboxylase: PDC5 MAE1 gly acetyl-L-lysine YDR524C-B chaperone: JAC1 methenyltetrahydrofolate protoheme phosphomethylpyrimidine NMA1 pyrimidinemethanol -4-methylthiazole hydroxymethyltransferase: thiazole chorismate α-D-galactopyranose F6P acyl-carrier protein acetate )-lipoyl]-L-lysine phosphatase: APP1 and incorporation (PDH, KGDH, GCV) pyruvate PDC1 pyruvate carboxy- [+ 3 isozymes] sn-glycerol thiamine ADP ribose 1’’,2’’- a [histone H3]- [acp] cys phosphoenolpyruvate a 1-palmitoyl-2- monoglutamate synthase: THI5 nicotinate nucleotide 5-hydroxy-6-methoxy- protoporphyrinogen pantetheine-phosphate ECM31 TMP pyruvate dihydrolipoyl formaldehyde succinate oxaloacetate pyruvate cyclohydrolase/ 5-demethoxyubiquinol lyase: PDC1 L-lysine-36 IDP arg a peptide heme o adenylyltransferase: 1,4-benzoquinol O- hydroxymethylpyrimidine 3-phosphate transsuccinylase: NADHX triphosphate cyclic phosphate 2’’- β-D-fructofuranose D-glucopyranose a proteinogenic acyl-sn-glycerol YGR026W a [co-chaperone]- methylenetetrahydrofolate FAD synthetase: oxidase: HEM14 adenylyltransferase: hydroxyethylthiazole preuroporphyrinogen diphosphorylase: decarboxylase: (S)-malate (R)-NADHX a peptide hydroxylase: COQ7 synthase: COX10 HMP-P NMA2 (HMP) kinase: THI21 Transport KGD2 epimerase: NNR1 phosphodiesterase cys amino acid [scaffold protein- dehydrogenase: ADE3 FAD1 methyltransferase: COQ3 CAB4 kinase: THI6 2-dehydropantoate THI6 PDC5 galactokinase: GAL1 an L-cysteine- methenyltetrahydrofolate nicotinate adenine HMP kinase: THI20 an octanoyl-[acp] pyruvate (S)-NADHX cyclic (2Fe-2S)] complex ferroheme o acetaldehyde S-conjugate YOR003W cyclohydrolase: MIS1 putative ubiquinol-6 protoporphyrin IX uroporphyrinogen diacetyl glucokinase: GLK1 3-demethylubiquinol-6 dinucleotide 3’-dephospho-CoA 4-methyl-5-(2- decarboxylase: phosphodiesterase: [+ 2 isozymes] 2-dehydropantoate thiamine phosphate acetoin carnitine shuttle L-cysteine α fructokinase: HXK2 an N 10 - phosphomethylpyrimidine FAD HMP-P phosphooxyethyl) III synthase: HEM4 PDC6 ATP-dependent CPD1 -D-galactose mannose a [1-Cys SSQ1 a 7,8-dihydrofolate S-adenosyl-L- desulfurase: UDP-α-D-glucose a 1-acyl-2- kinase: THI22 glutamine- 2-reductase: PAN5 synthase: PDC6 1-phosphate fructokinase: HXK1 degradation YER067W formyltetrahydrofolate heme a protoheme thiazole octanoyl [(R)-acetoin NADH-hydrate putative a protein with peroxiredoxin]- a long-chain an L-1-phosphatidyl- a supercoiled chaperone: SSQ1 methionine:2- hydroxymethylpyrimidine dependent NAD putative acetoin Pentose Phosphate NFS1 ISD11 D-glucopyranose tributyrin arachidonoyl- a carboxypeptidase a peptide with an 5’-deoxyadenosine benzylbenzoate a ribonucleoside 2-arachidonoylglycerol YGR152C dephospho-CoA TMP transferase: LIP2 forming]-diacetyl ADP ribose cystathionine beta- reduced L- sn-glycerol duplex DNA hexaprenyl-3-methyl- synthase: COX15 phosphate (HMP- ferrolyase: HEM15 uroporphyrinogen-III synthase: PDC5 dehydratase: NNR2 an [L-cysteine 6-phosphate (S-hydroxy-S a malonyl-[acp] fatty acyl-[acyl- sn-glycerol ATP diphosphate a D-amino acid dAMP dATP a [chaperone-ATP]- synthase: QNS1 kinase: CAB5 phosphomethylpyrimidine diphosphorylase: β-alanine Pathways acetyl-CoA L-carnitine CTP C substrate N-terminal L-lysine roseoflavin ribonucleoside- putative helicase: dihydrofolate (R)-pantoate a [glycine- acetoin reductase: BDH1 1’’-phosphate desulfurase]-S- D-mannopyranose lyase: YHR112C cysteine residues -oxocysteine) carrier protein] [co-chaperone]- phosphoribosylglycinamide 5-hydroxy-6-methoxy- P) kinase: THI21 kinase: THI22 pyruvate cysteine-S- 3-phosphate 5’-phosphate diphosphate YLR419W HMP-P folate transformations I THI6 synthase: PDC1 NADH glucose-6- TFIIH/NER YOL159C reductase: DFR1 formyltransferase: ADE8 1,4-benzoquinol O- ferroheme i hydroxymethylpyrimidine cleavage complex fermentation sulfanyl-L-cysteine D-amino-acid N- [scaffold protein- kinase: THI20 NAD + protoheme octanoyl-CoA (R)-acetoin pentose phosphate pathway cysteine mannokinase: HXK1 conjugate beta- S-methyl-5- putative reductase: complex ATPase/ dATP coenzyme A phosphate (HMP- H protein] N 6 - acetoin peroxisomal phosphate a mercapturate TGL1: TGL1 methyltransferase: COQ3 to ethanol II putative ADP- mannokinase: HXK2 lyase: IRC7 phosphatidate arginine/alanine acetyltransferase: diphosphatase: (2Fe-2S)] complex β desulfurase:TUM1 isomerase: PGI1 phospholipase A2: TGL4 carboxypeptidase thioadenosine carboxylic ester RNR1 RNR3 cardiolipin acylglycerol helicase subunit: P) kinase: THI21 thiamine phosphate pantoate -alanine octanoyl-L-lysine carnitine O- cysteine-S- cytidylyltransferase: HPA3 dAMP kinase: ADK1 ubiquinol-6 HMP-PP HMP-P Amine and Polyamine Biosynthesis ribose 1’’-phosphate D-mannopyranose 3-oxohexanoyl-[acp] TriacylGlycerol Lipase: TGL5 C: ATG42 aminopeptidase: phosphorylase: hydrolase: DDL1 RNR2 RNR4 lipase: YJU3 TFB2 TFB5 TFB4 NPP1 YGR241C a tetrahydrofolate heme a a 5,10-methylenetetrahydrofolate ligase: PAN6 D-glucopyranose acetyltransferase: sulfurtransferase: conjugate β- SulfiRedoXin: SRX1 FMN ribonucleotide- synthase: CRD1 YER143W SSQ1 chaperone kinase: THI20 octanoyl- octanoyl- pyruvate phosphatase: PDL32 synthase: CEM1 bifunctional triglyceride lipase/ CDS1 carboxypeptidase AAP1 [+ 2 isozymes] [+ 2 isozymes] synthase: COX15 lipoyl synthase: LIP5 6-phosphate ADP-ribose a ubiquitin- a [3-TUM1 F6P 6-phosphate lyase: STR3 putative phosphatidate vacuolar MEU1 adenylyltransferase: diphosphate SSL1 RAD3 ATPase: SSQ1 CoA-protein CoA-protein CAT2 lysophosphatidylethanolamine Y (proteinase an N-acetyl- Digs Into Agar: DIA3 NAD/NADP-NADH/NADPH UDP-N- pyruvate carboxy-lyase: PDC6 [+ 2 isozymes] 1’’-phosphate related modifier 1 mercaptopyruvate cytidylyltransferase: aminopeptidase FAD1 reductase: RNR2 TFB1 TFB6 SSL2 HMP-PP transferase: AIM22 transferase: AIM22 a [glycine- spermine and putrescine glucose-6- mannose-6- acyltransferase: TGL3 C): PRC1 D-amino acid YOL155C methylenetetrahydrofolate reductase: MET12 [+ 3 isozymes] (R)-pantothenate mitochondrial interconversion acetylglucosamine choline pyruvate decarboxylase: PDC5 sulfurtransferase]-S [+ 3 isozymes] TAM41 a 2’- KIN28 CCL1 TFB3 dADP dAMP a [chaperone- S-adenosyl-L-methionine cycle II hydroxyferroheme i cleavage complex pyruvate carboxy-lyase: PDC1 phosphate phosphatase: POA1 phosphate ysc1: APE1 RNR4 RNR1 a single methylenetetrahydrofolate reductase: MET13 NAD salvage a [pyruvate biosynthesis III methylthioadenosine biosynthesis III URM1 trehalose 2-aminoprop- 5-deoxy-α-ribose glycerol glycerol an [2Fe-2S] ADP]-[disordered- a [2-oxoglutarate- biosynthesis (R)-acetoin dehydrogenase: -sulfanyl-L-cysteine UDP-glucose:hexose- a thiol a [1-Cys benzoate benzyl alcohol deoxyribonucleoside Ptd 2 Gro arachidonate stranded DNA a 5,10-methylenetetrahydrofolate dehydrogenase H protein] N 6 -[(R biosynthesis coenzyme A ADP-D-ribose TUM1:MOCS3 isomerase: PMI40 pathway IV (from dehydrogenase acetaldehyde O-acetyl-L-carnitine adenylyltransferase: 1-phosphate UDP-glucose 4- degradation VI 2-enoate peroxiredoxin]-(S a protein with a long-chain 3- a CDP-1-acyl- adenine 1-phosphate 5’-diphosphate YHR006W cluster protein form scaffold biotin thiamine pantothenate )-lipoyl]-L-lysine ZWF1 acyl-carrier protein a proteinogenic roseoflavin adenine nicotinamide E2 protein] N 6 - NAD + UBA4 sulfurtransferase: (periplasmic) a disulfide bond oxoacyl-[acp] protein] complex a 5-methyltetrahydrofolate E2 protein] N 6 - F6P (R,R)-butanediol uridylyltransferase: epimerase: GAL10 F6P -hydroxycysteine) 2-arachidonoyl- a peptide dinucleotide biosynthesis kinase: CAB1 octanoyl-L-lysine putative glutamine- phosphocholine L-ornithine alcohol dehydrogenase IV: ADH4 6-phospho D- a carboxy- UBA4 butanoate 1,2-dibutyrin amino acid met methylenetetrahydrofolate β riboside) α lys a peptide YFL051C from 8-amino-7- 1-( -D octanoyl-L-lysine SAM dehydrogenase: glucono-1,5-lactone -D-glucopyranoseGAL7 α D-mannose α α glycerol SSQ1 chaperone NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase (NADP + ): ADE3 thiamine -fructose-6- choline-phosphate alcohol dehydrogenase: ADH5 adenylated- UDP- -D-galactose , -trehalose ribofuranosyl) superpathway of BDH1 ethanol dehydrogenase: ADH3 a [MOCS3]-S- 1-phosphate YOL154W ATPase: SSQ1 oxononanoate I dehydrogenase: MTD1 methylenetetrahydrofolate pyrophosphokinase: (R)-4’- lipoyl synthase: LIP5 NADH:ubiquinone phosphate cytidylyltransferase: ornithine 6-phosphogluconolactonase: [ubiquitin-related degradation D-xylose serine hydroxymethyltransferase: SHM2 glutathione metabolism lipoyl synthase: LIP5 sulfanylcysteine glycine cleavage system: GCV3 GCV1 GCV2 LPD1 nicotinamidenicotinamide phosphopantothenate decarboxylase: SPE1 ethanol dehydrogenase: ADH2 ferroheme a (8S)-8-amino- glycine hydroxymethyltransferase: SHM1 dehydrogenase (NADP + ): MIS1 γ THI80 a [pyruvate oxidoreductase 2 transaminase: PCT1 SOL4 modifier 1] degradation II methionine riboside (truncated -glutamyl cycle) S-adenosylmethionine ethanol dehydrogenase: ADH1 6-phosphogluconolactonase: a carboxymethyluridine 34 phosphoglucomutase: 2-iminopropanoate an [Fe-S cluster 5-methyltetrahydropteroyltriglutamate--homocysteine 7-oxononanoate7,8-diamino- a [2-oxoglutarate (external): NDE2 aldehyde dehydrogenase YMR084W CDP-choline (R,R)-2,3-butanediol D-mannopyranose trehalase: ATH1 2-[(2R,5Z)- a 1-acyl-2- YHR161C dehydrogenase glucoseamine- decarboxylase: SPE2 spermidine putrescine a [protein]-L- S-methyltransferase: MET6 adenosyltransferase: SAM1 kinase: NRK1 thiamine dehydrogenase NADH:ubiquinone NAD(+) kinase: POS5 SOL3 in tRNA URM1 PGM1 6-phosphate 2-carboxy-4- a peptide with arachidonoyl-sn- a dipeptidyl- D-sedoheptulose biosynthesis methionine pelargonic acid E2 protein] N 6 - (NAD+): ALD5 biosynthesis I ethanol GDP-α-D-mannose ω-saturated C55 sn-glycerol sn-glycerol sn-glycerol 5-formyltetrahydrofolate cyclo-ligase: FAU1 glutathione oxidoreductase 6-phosphate phosphoglucomutase: mannose-6- D-xylose a protein with glutathione a steryl-ester an MPP-processed glutamate-O 5 acetyl-CoA H 2 O diphosphate E2 protein] N 6 aldehyde diacylglycerol tRNA sulfurtransferase: a protein chaperone]-ATP adenosyltransferase: SAM2 aminotransferase: a tetrahydrofolate a 5,10-methenyltetrahydrofolate a (6S)-5-formyltetrahydrofolate NMN gamma- lipoyl-L-lysine - D-gluconate dolichol phosphate methylthiazol-5(2H an N-terminal glycero-3-phospho- peptidase 1-phosphate 3-phosphate 3-phosphate 3-phosphate a protein (internal): NDI1 D-glucosaminesynthase: GFA1 (carboxymethyluridine 34 - PGM2 phosphate D-xylose a disulfide bond mitochondrial protein HMP-PP -methyl-ester glycerol-3- glycerol-3- glycerol-3- BIO3 lipoyl-L-lysine NADH:ubiquinone dehydrogenase: ALD4 cholinephosphotransferase: dAdoMet spermidine 6-phosphate UBA4 )-ylidene]ethyl L-aspartate D-myo-inositol III substrate YFL005W (7R,8S)- glutamyltransferase: 6-phosphate bifunctional UDP-glucose 4- phosphate 1-O- EGT2 (8S)-8-amino- (8S)-8-amino- nicotinamide-nucleotide CPT1 5-O)-methyltransferase: wybutosine D-glucopyranose isomerase: PMI40 reductase: YPR1 phosphate 1-O- phosphate 1-O- YNR056C diaminononanoate ECM38 oxidoreductase 1 diacylglycerol SAM 6-phosphogluconate epimerase/aldose 1-epimerase: GAL10 [+ 2 isozymes] phosphate 4,5-bisphosphate adenylyltransferase: superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) glucosamine- TRM9 TRM112 F6P α-D-glucopyranose β-D-glucopyranose bifunctional triglyceride lipase/ acyltransferase: acyltransferase: acyltransferase: 7-oxononanoate 7-oxononanoate L-homocysteine SAM formate--tetrahydrofolate ligase: MIS1 trifunctional formate-tetrahydrofolate ligase/ (external): NDE1 dehydrogenase, a thiocarboxylated- biosynthesis 6-phosphate fructose- vacuolar saaccharolysin: cholinephosphotransferase: a 5-(2-methoxy- xylitol dolichyl-phosphate beta- bifunctional aspartyl phosphoinositide- protein-glutamate SCT1 folate polyglutamylation formate--tetrahydrofolate ligase: ADE3 methenyltetrahydrofolate cyclohydrolase/ POF1 6-phosphate N- spermine [ubiquitin-related pyruvate protein-disulfide lysophosphatidylethanolamine acetyl-CoA glycerol-3- glycerol-3-SCT1 protease B: PRB1 glycerol-3-SCT1 PRD1 dethiobiotin nicotinamide NADP + decarboxylating: 2-oxoethyl) D-mannosyltransferase: intermediate methylesterase: bisphosphate acetyltransferase: EPT1 reductase acyltransferase: TGL3 hydroxyethylthiazole aminopeptidase: specific YOL057W: hydrolase: ACH1 methylenetetrahydrofolate dehydrogenase: ADE3 mononucleotide prenylated synthase: SPE4 S-adenosylmethionine GND1 modifier 1] cleaving peptidase aldolase: FBA1 phosphate-O- phosphate-O- phosphate-O- S-adenosyl-L- synthetase: BIO4 an α-(γ-L-glutamyl) NAD + uridine 34 in tRNA guanine 37 in tRNA Phe DPM1 sterol esterase: YEH2 PPE1 methenyltetrahydrofolate cyclohydrolase: MIS1 L-cysteinylglycine GNA1 a phosphatidylcholine (glutathione): GRX1 kinase/thiamine- APE4 phospholipase YOL057W YJL062W NAD salvage pathway adenylyltransferase: Cys-Gly FMNH 2 NADH N-acetyl-D- decarboxylase: SPE2 D-ribulose sterol esterase: YEH1 55: ICP55 vacuolar acyltransferase: acyltransferase: acyltransferase: a tetrahydrofolate homocysteine -L-amino acid [+ 2 isozymes] phosphate C: PLC1 a peptide a peptide aldehyde:NAD+ 5-phosphate tRNA-5-(2- tRNA Phe (guanine 37 -N 1 )- GPT2 1-(18-GPT2 1-arachidinoyl-GPT2 TOS6 V (PNC V cycle) nicotinamideNMA2 metallodipeptidase: biosynthesis aldehyde dehydrogenase glucosamine β TriGlyceride Lipase: TGL1 aminopeptidase hydrolase: SAH1 dethiobiotin oxidoreductase: ALD2 NAD(+) kinase: POS5 spermine methoxy-2- -D-mannosyl- diphosphorylase: THI6 1-palmitoyl-sn- YGL114W 10 6-phosphate methyltransferase: TRM5 [+ 2 isozymes] hydroxyoleoyl)-sn- sn-glycerol an N -formyltetrahydrofolate mononucleotide DUG1 aldehyde:NAD+ (NADP+): ALD5 phospholipase (C55 ω-saturated ysc1: APE1 a [protein]-α- glycerol 3-phosphate NAD(+) kinase: YEF1 putrescine dAdoMet oxoethyl)uridine 2- MeOH acetate DHAP D-erythrose thiazole NADH kinase: POS5 aldehyde N-acetylglucosamine- D-ribulose-5- ribose-5- an N 1 -methylguanine 37 Amino Acid Degradation Cofactor, Prosthetic Group, a protein with an 1-acyl-2- glycrol 3-phosphate 3-phosphate formate--tetrahydrofolate folyl-polyglutamate serine NAD + adenylyltransferase: oxidoreductase: ALD3 NAD(+) kinase: UTR1 prenol DMAPP D: SPO14 dolichyl phosphate) GDP a fully-processed L-glutamate pyridoxal 5’-phosphate salvage I dehydrogenase: ALD4 sulfurtransferase: in tRNA Phe Electron Carrier Degradation GSSG arachidonoyl- a dipeptide ligase: MIS1 synthase: RMA1 hydroxymethyltransferase: biosynthesis III NMA1 aldehyde dehydrogenase phosphate Phosphate 3- phosphate ketol- reduced L- a peptide Ins(1,4,5)P 3 a peptide biotin synthase: BIO2 NCS6 mitochondrial protein thiamine phosphate sn-glycerol formate--tetrahydrofolate folylpolyglutamate γ (NAD+): ALD5 mutase: PCM1 epimerase: RPE1 isomerase: RKI1 valine cysteine residues a fatty acid a sterol YJL219W SHM2 SAH protein acetyllysine N- -L-glutamyl- NADP + spermidine periplasmic asp a peptide glycine NAD + cys aldehyde N-acetyl-α-D- choline ligase: ADE3 synthetase: MET7 synthase: SPE3 a 5-(2-methoxy- tRNA-4-demethylwyosine degradation L-lysine L-methionine isoleucine glutathione YNL190W acetyltransferase: SIR2 L-cysteine dehydrogenase: ALD4 NADPH NAD hydroxymethyltransferase: gly pyridoxine pyridoxamine glucosamine D-xylulose D-ribose 5- 2-oxoethyl)2- synthase: TYW1 degradation III degradation III degradation isoleucine NAD + biotin [+ 5 isozymes] dehydro-D-arabinono- L-phenylalanine degradation degradation SHM1 hydroxymethylpyrimidine glutathione NADH 1-phosphate 5-phosphate phosphate thiouridine 34 in tRNA an N 10 - glutamine-dependent putative pyridoxal putative pyridoxal aldehyde dehydrogenase NADP-dependent 1,4-lactone biosynthesis UDP-N- degradation degradation II (DUG pathway) YGR041W a tetrahydrofolate synthetase: GSH2 glucose-6-phosphate acetaldehyde:NADP+ 4-demethylwyosine 37 YGR065C formyltetrahydrofolate nicotinateNAD adenine synthase: QNS1 salvage gamma- (NADP+): ALD5 isocitrate spermidine val II (anaerobic) biotin biotin nicotinamide kinase: BUD17 kinase: BUD17 dehydrogenase: ZWF1 oxidoreductase: ALD6 acetylglucosamine NAD + a mitochondrial a 5,10- dinucleotide nicotinamidase: PNC1 aldehyde in tRNA Phe L-valine:2- lys met ile (1S,2R)-1-C- a 1-phosphatidyl- a 2-acyl-1-alkyl- a supercoiled a kinesin- folyl-polyglutamate adenylated thiazole pyridoxine pyridoxamine glutamylcysteine dehydrogenase: IDP2 prenyl phosphate pyrophosphorylase: transketolase: TKL1 glutathione a tRNA precursor preprotein including detyrosinated a trans-2-enoyl- methylenetetrahydrofolate amidase: AMD2 NADH kinase: UTR1 D-arabinofuranose tRNA 4-demethylwyosine L-phenylalanine:2-oxo- NADH a ferrocytochrome b 14-demethyllanosterol (indol-3-yl)glycerol cys 1D-myo-inositol a 1-acyl-sn-glycerol sn-glycerol 3’,5’-ADP synthase: RMA1 synthase: THI4 4-amino-2-methyl-5- kinase: BUD16 kinase: BUD16 synthetase: GSH1 dehydrogenase: ALD4 Glycolysis transketolase: TKL2 oxoglutarate L-isoleucine:2-oxoglutarate ile glutathione 5 ser L-homocysteine α tyr asp O-ureido-L- duplex DNA a decanoyl-[acp] a protein microtubules YGR260W pyridoxal 5’-phosphate NADH kinase: YEF1 aldehyde:NADP+ D-arabinose 1- QRI1 α-amino-α- phe pyrophosphatase: with a 5’ extension a mitochondrial -tubulin [acyl-carrier protein] dna HeliCaSe: YNL160W nicotinate nicotinate folypolyglutamate folyl-polyglutamate lipoate pyrimidinemethanol UDP-N-acetyl- aminotransferase: 4-methylthiobutanoate aminotransferase: BAT1 L-isoleucine:2-oxoglutarate γ-glutamate 3-phosphate homoserine 4-phosphate 3-phosphatebifunctional complex nicotinate nucleotide hydroxymethylpyrimidine pyridoxamine pyridoxal biosynthesis II NADH kinase: POS5 oxidoreductase: ALD6 flavin D-arabinose dehydrogenase protein S- carboxypropyltransferase: L-phenylalanine:2- branched-chain amino NPY1 targeting sequence HCS1 synthetase: MET7 synthase: RMA1 salvage I ADP-5-ethyl-4- pyridoxine α-D-glucosamine BAT1 aminotransferase: aminotransferase: BAT1 hydrolase: ECM38 diacylglycerol 3’(2’)5’- DNA 3’-5’ helicase: adenylyltransferase: NMA1 prenyltransferase: (NAD(P)(+)): ARA2 D-sedoheptulose D-glyceraldehyde nitrosylation and branched-chain oxoglutarate glutathione enoyl-[acyl- enoyl-[acyl- Ca2+-dependent KInesin related folypolyglutamate (HMP) kinase: THI21 5’-phosphate 5’-phosphate dehydrogenase: D-arabinose glutathione- glycolysis III 7-[(3S)-3-amino-3-TRM12 ARO8 (S)-3-methyl-2-acid transaminase: BAT2 branched-chain amino diphosphate an N 10 - methylthiazole- nicotinate nucleotide L-phenylalanine:2-oxo- phosphoinositide- monoacylglycerol bisphosphate SLD5 PSF1 PSF3 HMP kinase: THI20 glutathione redox reactions I PAD1 ARA2 (from glucose) glycolysis 7-phosphate 3-phosphate denitrosylation amino acid N 6 -acetyl-L-lysine aminotransferase: AMP hydrolase: ribonuclease P: RPR2 carrier-protein] carrier-protein] serine Protein: KIP2 synthetase: MET7 2-carboxylate dehydrogenase: glutaredoxin carboxypropyl]-4- oxopentanoate (S)-3-methyl-2-acid transaminase: BAT2 mitochondrial- lipase: MGL2 phosphatase/ nucleotidase: MET22 PSF2 MCM2 YGR197C YKL187C formyltetrahydrofolate adenylyltransferase: NMA2NaMN nicotinate putative pyridoxal NADPH 3-methyl-2-transaminase: BAT2 4-methylthiobutanoate putative tubulin specific reductase: ETR1 reductase: ETR1 protease: KEX2 [+ 2 isozymes] (R)-lipoate HMP-P aldehydo-D- D-glyceraldehyde gln base-degraded demethylwyosine 37 3-phenyl-2-ARO8 DUG3 DUG2 C-4 methyl sterol tryptophan POP8 POP7 POP6 processing cystathionine beta- argininosuccinate monoacylglycerol phosphatidate a 5,10- 4-methyl-5-(2- pyridoxine pyridoxiamine ARA1 system a [protein]- protein ubiquitination aminotransferase: oxopentanoate tyrosine MCM6 MCM4 putative kinase: BUD17 ribose 5-phosphate 3-phosphate thiamin salvage S-adenosyl-L- prenylated FMNH D-arabinono- oxobutanoate oxopropanoate 2-keto-methylvalerate L-cysteinylglycine POP1 POP5 POP4 phospholipase 2 D-glucopyranose transaldolase: in tRNAtRNAPhe Phe [7-[(3S)-(3- oxidase: ERG25 synthetase: TRP5 peptidase: synthase: CYS4 synthase: ARG1 lipase: YJU3 phosphatase: DPP1 a kinesin- methylenetetrahydrofolate phosphonooxyethyl) putative 5’-phosphate 5’- phosphate pyridoxal D-glucopyranose L-cysteine ARO9 decarboxylase: THI3 2-keto-methylvalerate ligase: PBY1 C: PLC1 phosphatidate a 2,3,4-saturated MCM3 MCM7 a (2E)-dec- YNL066W lipoate--protein methionine GSSG 1,4-lactone NQM1 amino-3-carboxypropyl)- branched-chain- methionine-oxo- phenylpyruvate (3S)-3-methyl- IMP 5’- RPP1 POP3 RPR1 MAS2 MAS1 a peptide microtubules thiazole synthase: THI4 oxidase: PDX3 oxidase: PDX3 kinase: BUD16 GSSG 6-phosphate decarboxylase: THI3 Cys-Gly [+ 2 isozymes] phosphatase: APP1 AMP MCM5 CDC45 ligase: AIM22 phosphomethylpyrimidine formylaminopyrimidine biosynthesis transaldolase: TAL1 a [ubiquitin] C- 2-oxoacid acid transaminase: fatty acyl-[acp] a single 2-enoyl-[acp] nicotinate phosphoribosyl cytochrome pyridoxal 5’-phosphate D-arabinono- 4-demethyl]wyosine-N 4 ]- carboxy- 2-oxopentanoate (3S)-3-methyl- nucleotidase: ISN1 a 2-acyl-1-alkyl- complex 4-methyl-5-(2- acyl carrier kinase: THI22 glucokinase: GLK1 glucose-6- metallodipeptidase: stranded DNA [(R)-lipoyl]adenylate hydroxymethylpyrimidine synthase: SNZ3 SNO3 terminal glycine methyltransferase: TYW3 decarboxylase: THI3 4-(methylsulfanyl)AAT2 lyase: ARO10 carboxy-lyase: ARO10 2-oxopentanoate 4α-carboxy-4β- glycerol sn-glycerol phosphooxyethyl) protein transferase: NPT1 c biogenesis 1,4-lactone 2-oxoisovalerate phenylpyruvate DUG1 D-glyceraldehyde a 1,2-diacyl- a fatty acid YKR100C nicotinate thiamin pyridoxal 5’-phosphate [+ 2 isozymes] phosphate E1 ubiquitin- 7-[(3S)-(3-amino- 2-keto-6- -2-oxobutanoate 2-keto-3-methylvalerate α thiazole phosphate (HMP- PLP met Glutathione oxidase: ALO1 D-erythrose carboxy- carboxy-lyase: ARO10 methyl-5 -cholesta- an MPP-processed α canavaninosuccinate sn-glycerol Ins(1,4)P 2 riboside salvage salvage III activation Polyprenyl Biosynthesis isomerase: PGI1 F6P 3-carboxypropyl)]- acetamidocaproate carboxy- carboxy-lyase: PDC1 2-keto-3-methylvalerate a ferricytochrome b 5 3-phosphate trp a peptide L-cystathionine tyrosinated -tubulin YGR266W nicotinamide putative P) kinase: THI21 synthase: SNZ2 SNO2 aminomethylpyrimidine methionine glutathione glutathione-disulfide dehydro-D- glutathione-disulfide 4-phosphate a [protein] 3- activating protein: 8,24-dien-3β-ol a tRNA fragment an uncharged tRNA mitochondrial protein pyridoxal 5’-phosphate peroxidase: GPX1 D-glucopyranose 37 in tRNA Phe lyase: PDC1 2-oxo-4- lyase: PDC1 2-keto-3-methylvalerate adenosine pathway I lipoate--protein HMP-P kinase: THI20 protoheme peroxidase: GTT1 reductase: GRX6 reductase: GRX6 UBA2 AOS1 wyosine decarboxylase: carboxy-lyase: PDC1 cys ICWP riboside salvage adenosyltransferase: glutathione arabinono- nitrosothio-L-alanine E1 ubiquitin- methylthiobutanoate phenylpyruvate carboxy-lyase: PDC5 2-keto-3-methylvalerate an apo acyl- cytochrome c1 synthase: SNO1 SNZ1 [+ 3 isozymes] [+ 3 isozymes] [+ 3 isozymes] 6-phosphate F6P 7-(3-amino-3- pathway II ligase: AIM22 SAM1 peroxidase: GPX2 1,4-lactone superpathway of transketolase: TKL2 PDC5 carboxy- 2-keto-3-methylvalerate β thiamine carrier protein HMP-PP heme lyase: CYT2 thiaminase II: THI20 methionine activating carboxypropyl)-wyosine 2-oxoisovalerate carboxy-lyase: ARO10 carboxy-lyase: PDC5 -D-ribosylnicotinate 1-(β-D a [lipoyl-carrier CCHL geranylgeranyldiphosphate geranyl glucose-6- transketolase: TKL1 lyase: PDC5 carboxy-lyase: PDC6 2-keto-3-methylvalerate thiamine an [E1 ubiquitin-protein: UBA1 phenylpyruvate protein]-N 6 -[(R) Phosphopantetheine:Protein adenosyltransferase: biosynthesis I (via mevalonate) diphosphate methyltransferase: PPM2 carboxy- 3-(methylsulfanyl) YLL053C nicotinate riboside ribofuranosyl) holocytochrome phosphate phosphofructokinase: carboxy-lyase: PDC6 a 1-acyl-2- a protein pyrophosphokinase: Transferase: PPT2 PLP SAM2 activating enzyme]- 7-[(3S)-4-methoxy-(3- lyase: PDC6 carboxy- 2-methylbutanal a very-long- a protein that a peptide with a (3R)-3- a protein with nicotinamide -lipoyl]-L-lysine c synthase: CYC3 4-amino-2-methyl-5- biosynthesis isomerase: PGI1 PFK1 PFK2 D-glyceraldehyde 5-acetamidovalerate propanal a phytoceramide an unsulfurated O-phospho- lauroyl-CoA H O arachidonoyl- a carboxylic ester [a DNA-directed containing an (L- kinase: NRK1 THI80 nicotinamide ribose SAM glutathione glutathione S-ubiquitinyl- lyase: PDC6 2 hydroxydecanoyl- a holo acyl- acetyl-CoA 3-phosphate amino-3-carboxypropyl) 2-methylbutanal a ferrocytochrome b 5 chain fatty acid ends with a GGPP cys an N-terminal cys a protein a protein a protein incorrect thiamine a c-type cytochrome pyrimidinemethanol isobutanal alcohol 2-methylbutanol:NAD+ [sulfur carrier] L-homoserine phosphatidylcholine RNA-polymerase] serine/L-threonine) YHR048W nucleosidase: URH1 β L-cysteine ]-wyosine 37 in tRNA Phe CaaL sequence L-amino acid [acp] disulfide bonds YLR110C NaMN diphosphate carrier protein IPP F6P -D-fructose a [protein]- 7-(3-amino-3- dehydrogenase phenylacetaldehyde -L-proline motif acetyl-CoA C- S-nitrosoglutathione PEroXin: PEX4 oxidoreductase: SFA1 2-methylbutanol:NAD+ (3R)-3- Suppressor of mitogen- Multicopy nicotinamide 1,6-bisphosphate L-cysteine methylcarboxypropyl) isobutanol:NAD+ IV: ADH4 2-methylbutanol putative acyltransferase: POT1 dimethylallyltransferase: [+ 10 isozymes] methionol:NAD+ aldehyde oxidoreductase: SFA1 acyl-CoA hydroxyacyl-[acyl- SNf1: SSN8 activated protein vacuolar suppressor EPS1: EPS1 acetyl-CoA -wyosine oxidoreductase: dehydrogenase: ADH5 2-methylbutanol very-long-chain carboxylic ester metalloprotease: YLR121C ERG20 phosphofructokinase: S-nitrosoglutathione an [E2 ubiquitin- oxidoreductase: ceramide very long protein L-cysteine vacuolar cystathionine thioesterase: ATF1 phospholipase carrier-protein] SRB8 SSN2 SSN3 kinase: HOG1 proteinase A: PEP4 of Kex2 Cold [+ 4 isozymes] carboxycarbonylase: PPM2 SFA1 dehydrogenase: 2-methylbutanol fatty acid--CoA acyl-CoA hydrolase: CLD1 ATP23 acetyltransferase: ERG10 PFK1 PFK2 dehydrogenase: conjugating isobutanol SFA1 dehydrogenase: ADH5 D: SPO14 dehydratase: HTD2 [+ 2 isozymes] [+ 4 isozymes] sensitivity: MKC7 Aminoacyl- ALD4 dehydrogenase: ADH4 2-methylbutanol chain fatty acid ligase: FAT1 geranylgeranyltransferase desulfurase: aminopeptidase gamma- [+ 2 isozymes] a protein containing 5-aminopentanoate methionol aldehyde thioesterase: TES1 phospho-[DNA- a protein geranyl diphosphate aldolase: FBA1 SFA1 enzyme]-S wybutosine 37 in tRNA Phe dehydrogenase: 2-methylbutanol hydroxylase: SCS7 type I complex: CDC43 RAM2 NFS1 ISD11 ysc1: APE1 synthase: STR2 YLR188W tRNA Charging acetoacetyl-CoA β dehydrogenase: dehydrogenase: ADH4 a (2E)-dec- a phosphorylated (L- a peptide a peptide YLR042C -D-fructose -ubiquitinyl- ADH5 dehydrogenase dehydrogenase: ADH3 2-methylbutanol directed RNA- a peptide a peptide a peptide with correct S-(hydroxysulfenamide) isobutanol 2-enoyl-[acp] serine/L-threonine) 1,6-bisphosphate L-cysteine ADH2 (NAD+): ALD5 2-methylbutanol dehydrogenase: ADH3 a 1-acyl-2- polymerase] disulfide bonds glutaminyl-tRNA gln triosephosphate methionol:NAD aldehyde:NAD+ glutathione dehydrogenase: dehydrogenase: ADH2 2-methylbutanol a very-long-chain -L-proline motif YLR241W hydroxymethylglutaryl- D-glyceraldehyde HECT-type oxidoreductase: laurate arachidonoyl- choline an alcohol a carboxylate biosynthesis via isomerase: TPI1 ADH4 oxidoreductase: [+ 2 isozymes] a (2’R)-2’-hydroxy- diphosphate fatty acyl-CoA a geranylgeranylated CoA synthase: ERG13 DHAP isobutanol ADH5 dehydrogenase: ADH2 AMP a sulfurated a proteinogenic sn-glycerol transamidation aldolase: FBA1 3-phosphate E3 ubiquitin ALD3 [+ 2 isozymes] phytoceramide a ferricytochrome b 5 protein that ends with ala a peptide L-cystathionine RING-type dehydrogenase: glutarate methionol aldehyde:NAD+ [sulfur carrier] amino acid 3-phosphate glyceraldehyde- transferase: 2-methylbutanol a CaaL sequence YIL105C E3 ubiquitin ADH3 semialdehyde reductase: ADH1 oxidoreductase: Other Biosynthesis HMG-CoA 3-phosphate RSP5 BUL2 isobutanol methionol 2-methylbutanol YLR040C glu hexaprenyl [+ 3 isozymes] transferase: ALD2 gln dehydrogenase: dehydrogenase: dehydrogenase: diphosphate triosephosphate hydroxylamine a [HECT-type UBX2 SSM4 YLR343W meso- (R,R)- 3-hydroxy-3methylglutary- D-glyceraldehyde TDH1 [+ 27 isozymes] ADH2 ADH3 arginine a medium-chain isomerase: TPI1 phenylacetate a protein that a diphospho-1D- type-1 glutamate CoA reductase: HMG2 biosynthesis DHAP [+ 2 isozymes] E3 ubiquitin isobutanol an N-modified a siderophore- an L-glutamyl- butanediol butanediol 3-phosphate HECT-type degradation a dihydroceramide 2,3,4-saturated an exoaminopeptidase a peptide with an N- an acyl-CoA H 2 O cyclic-GMP L(or D)-O- a RAD21 3-hydroxy-3- transferase]- dehydrogenase: methionol a ferrocytochrome b 5 GGPP ends with an bound Fe(III) myo-inositol transmembrane a dodecanoyl-[acp] a palmitoyl-[acp] synthase: GLT1 biosynthesis II biosynthesis E3 ubiquitin VI (arginase fatty acid aminoacyl-[tRNA] substrate terminal L-alanine 3’,5’-cyclic-nucleotide phosphoserine cohesin subunit [tRNA Gln ] pyridoxal 5’- methylglutaryl-CoA (2E,6E)-farnesyl glyceraldehyde- S-ubiquitinyl- XCXC sequence tetrakisphosphate proteins glutaminyl- 13-DPG transferase: UFD4 ADH1 phosphodiesterase, diadenosine and reductase: HMG1 3-phosphate glutarate leucine L-methionine 2 pathway) putative rhomboid tRNA synthase YLR037C phosphate synthase: diphosphate L-cysteine [+ 3 isozymes]a [protein]-N 6 - diphosphoinositol enoyl-[acyl- enoyl-[acyl- (S)-acetoin (R)-acetoin hexaprenyl isobutanol degradation low affinity: PDE1 protease: RBD2 (glutamine- YJL145W SNZ3 SNO3 an L-glutamyl- dehydrogenase: monoubiquitinyl- degradation I (to long-chain acyl-CoA putative high affinity cAMP polyphosphate phosphoserine Processing of pyridoxal 5’- (R,S)-2,3- (R,R)-butanediol arg Peptidyl-Trna carrier-protein] carrier-protein] separase: ESP1 YLR414C (R)-mevalonate diphosphate TDH1 ammonium L-homocysteine) fatty acid-CoA thioesterase: TES1 ferric-chelate phosphodiesterase: phosphatase: SER2 hydrolysing) [tRNA Gln ] butanediol [+ 2 isozymes] 3-phosphoglycerate L-lysine dihydroceramide metallo- arginine/alanine phosphohydrolase: Cytochrome c reductase: ETR1 reductase: ETR1 phosphate synthase: dehydrogenase: synthase: COQ1 ligase: FAA2 Rab geranylgeranyltransferase: Hydrolase: PTH1 acyl-CoA reductase: FRE8 : PET112 glutaminyl- dehydrogenase: all-trans-hexaprenyl kinase: PGK1 C4-hydroxylase: aminopeptidase: aminopeptidase: PDE2 DDP1 Peroxidase: PCP1 SNZ2 SNO2 BDH1 leucine leu [+ 3 isozymes] BET2 BET4 MRS6 aminoacyl-tRNA thioesterase: ATF1 [+ 5 isozymes] D-myo-inositol cleaved type-1 HER2 GTF1 pyridoxal 5’- tRNA synthase met arginase: CAR1 SUR2 APE2 AAP1 a (2E)-dodec- a (2E)-hexadec- an L-glutaminyl- BDH1 mevalonate kinase: ERG12 diphosphate 13-DPG degradation III L-leucine:2-oxoglutarate hydrolase: PTH2 1,3,4,5,6- serine transmembrane a peptide phosphate synthase: (R,S)-2,3-butanediol (R,R)-2,3-butanediol 3-phospho- methionine GMP [tRNA Gln (glutamine- pentakisphosphate 2-enoyl-[acp] 2-enoyl-[acp] ] YLR001C D-glycerate aminotransferase: BAT1 proteins SNO1 SNZ1 hydrolysing) branched-chain amino adenosyltransferase: L-ornithine a medium-chain GMP synthase: 5-oxo-L-proline metabolism glutamine Ste4-Ste18 YML002W SAM1 2,3,4-saturated diphosphate a carboxylate Fe 2+ a siderophore : PET112 (R)-5-phosphomevalonate 3-phosphoglycerate leu acid transaminase: BAT2 methionine a (C18)- a geranylgeranylated heterodimer GUA1 degradation I 4-methyl-2-oxopentanoate AMP fatty acyl CoA an N-modified a proteinogenic HER2 GTF1 kinase: PGK1 phytoceramide a ferricytochrome b 5 protein that ends with an uncharged tRNA a peptide ala a peptide [+ 8 isozymes] L-leucine:2-oxoglutarate adenosyltransferase: ornithine amino acid amino acid a 5-phosphooxy-L- a [protein] with a [protein] with aminotransferase: BAT1 SAM2 aminotransferase: a XCXC sequence phosphomevalonate ammonium glutamyl-[tRNA Gln ] 3-phospho- an N-terminal an N-terminal branched-chain amino keto-isocaproate SAM CAR2 tRNA charging kinase: ERG8 2-phospho- gln YKL096W-A D-glycerate L-glutamine L-glutamate glutamate synthase: GLT1 acid transaminase: BAT2 decarboxylase: THI3 phosphoglycerate D-glycerate 4-methyl-2-oxopentanoate L-glutamate-5- 1D-myoinositol YML132W pyridoxal 5’-phosphate a protein that a pyrophosphate- (R)-4-hydroxy- glutaminyl- a protein that a peptide with 5-diphosphate a siderophore- 4-hydroxy-4-methyl- (R)-mevalonate mutase (2,3- phophopyruvate synthase: SNZ3 SNO3 semialdehyde hydrogen selenide an L-cysteinyl- a uridine 55 in tRNA a reduced c- 4-methyl-2- a dolichyl tRNA synthase 3-methylbutanal O-acetyl-L-serine ends with an ends with an a protein an N-terminal bound Fe(III) 2-oxoglutarate containing cys YKL105C pyridoxal 5’-phosphate GGPP GGPP Cys 1,2,3,4,6- bifunctional 4- bifunctional 4- ATP diphosphate elongator tRNA Met thr Thr lys a tRNA Lys glu trp Trp Tyr phe a tRNA Phe diphosphate diphosphoglycerate- hydratase: ERR3 keto-isocaproate [tRNA ] bifunctional DRAP type cytochrome oxoglutarate (glutamine- met a tRNA glu a tRNA a tRNA tyr a tRNA CCXX sequence XXCC sequence L-methionine 1D-myoinositol 5- inositol phosphatediadenosine and Asn Pro Arg Ala a tRNA Ile Leu Gly synthase: SNZ2 SNO2 pentakisphosphate hydroxy-4-methyl- deaminase/tRNA hydroxy-4-methyl- asn tRNA pro a tRNA arg a tRNA a tRNA ala ile leu a tRNA gly a tRNA dependent): GPM1 [+ 4 isozymes] decarboxylase: THI3 3-methylbutanol:NAD+ hydrolysing) mevalonate diphosphate pyridoxal 5’-phosphate diphosphate 1,2,3,4,6- 2-oxoglutarate diphosphoinositol 2-oxoglutarate tRNA asp asp 2-phospho- pseudouridine YKR102W val YDR046C val : PET112 decarboxylase: MVD1 a [protein] with synthase: SNO1 SNZ1 oxidoreductase: SFA1 bifunctional cysteine synthase/ pentakisphosphate cytochrome c cystathionine beta- val a tRNA Val initiator tRNA Met met ser a tRNA ser cys a tRNA Cys gln a tRNA Gln his a tRNA His phosphoenol SAH ferric aldolase/ polyphosphate aldolase/ CAX4: CAX4 Mitochondrial aminoacyl- Mitochondrial aminoacyl- Mitochondrial aminoacyl- Mitochondrial aminoacyl- Mitochondrial aminoacyl- Mitochondrial aminoacyl- mevalonate pyrophosphate D-glycerate glutathione γ-L-glutamyl GMP synthase: GUA1 3-methylbutanol Secondary Metabolite methionine synthase:tRNA RIB2 adenylate cyclase: HER2 GTF1 W (tryptophan) RS pyruvate an N-terminal 3-methylbutanal O-acetylhomoserine phosphatase:diadenosine and SIW14 oxaloacetate phosphohydrolase: peroxidase: CCP1 synthase: CYS4 oxaloacetate arginine--tRNA Isoleucyl tRNA Synthetase Glycyl-tRNA decarboxylase: MVD1 [+ 8 isozymes] dehydrogenase: ADH5 Rab geranylgeranyltransferase: Rab geranylgeranyltransferase: carboxypeptidase aminoacyl-tRNA reductase: FRE1 CYR1 SRV2 tRNA Synthetase, asparagine--tRNA proline--tRNA tRNA Synthetase, putative alanine--tRNA tRNA Synthetase, tRNA Synthetase, (tRNA synthetase): WRS1 tRNA Synthetase, Cell Division tRNA Synthetase, phophopyruvate 5-oxo-L-proline 5-phosphate (S)-1-pyrroline- Degradation aminocarboxypropyltransferase: aminopeptidase: [+ 6 isozymes] pseudouridine 55 Mitochondrial aminoacyl- Mitochondrial aminoacyl- pyruvate glu 3-methylbutanol S-adenosyl-L- hydrolase: PTH2 diphosphoinositol decarboxylase: DDP1 decarboxylase: Methionine: MSM1 ligase: DED81 ligase: YHR020W ligase: MSR1 Threonine: MST1 ligase: YNL040W lysine (K): MSK1 Glutamate (E): MSE1 of Mitochondria: ISM1 tyrosine (Y): MSY1 Cycle: CDC60 Phenylalanine (F): MSF1 Synthase: GRS2 3-methylbutanol:NAD+ 5-carboxylate BET2 BET4 MRS6 BET2 BET4 MRS6 D: KEX1 MAP1 a myo-inositol- synthase: PUS4 YMR086W an L-glutaminyl- VAlyl-tRNA MEthionyl-tRNA methionine--tRNA THreonyl tRNA GlUtamyl-tRNA GLutamiNe TYrosyl-tRNA phenylalanyl (F)-tRNA hydratase: ERR3 kinase: PYK2 glutathione-specific gamma- dehydrogenase: ADH4 MET17 [+ 2 isozymes] polyphosphate YER010C an oxidized c- YER010C a dolichyl phosphate serine--tRNA ligase: DIA4 asparagine--tRNA proline--tRNA arginine--tRNA ALAnyl-tRNA Lysyl (K) tRNA tRNA Synthetase, isoleucine-- tRNA Synthetase, Nuclear Accommodation Histidine-Trna Glycyl-tRNA IPP [+ 4 isozymes] oxidoreductase: SFA1 homocysteine sorbitol cysteine synthase: MCY1 a pseudouridine 55 lanthionine cyclic-AMP YLL005C [tRNA Gln ] YNL247W: YNL247W pyruvate 3-methlbutanol pyruvate polyphosphate pyruvate Synthetase: VAS1 Synthetase: MES1 ligase: MSM1 serine--tRNA ligase: SES1 ligase: SLM5 ligase: AIM10 ligase: YDR341C Synthetase: THS1 synthetase: ALA1 Synthetase: KRS1 Synthetase: GUS1 tryptophan (W): MSW1 metabolism: GLN4 tRNA ligase: ILS1 Synthetase: TYS1 Aspartate (D): MSD1 of Mitochondria: NAM2 Synthetase: HTS1 Synthetase: FRS2 FRS1 Synthase: GRS1 glutamylcyclotransferase: 3-methylbutanol hydrolase: SAH1 pyrroline-5- xylitol phosphohydrolase: in tRNA type cytochrome kinase: CDC19 dehydrogenase: ADH3 degradation phosphoenol GCG1 dehydrogenase: ADH5 3-methylbutanol carboxylate degradation DDP1 YKR042W 3-methylbutanol reductase: PRO3 a geranylgeranylated a geranylgeranylated Ins(1,2,3,4,5,6)P 6 Fe 2+ a siderophore IPP isomerase: IDI1 pyruvate pyruvate dehydrogenase: ADH2 L-homocysteine acetate an L-methionyl- an L-methionyl- an L-phenylalanyl- dehydrogenase: ADH4 [+ 2 isozymes] D-sorbitol L-selenocysteine protein that ends with protein that ends with a basic amino acid a protein cys a tRNA Cys met a peptide an L-valyl-[tRNA Val ] an L-seryl-[tRNA ser ] an L-asparaginyl-[tRNA Asn ] an L-prolyl-[tRNA Pro ] an L-arginyl-[tRNA Arg ] an L-threonyl-[tRNA Thr ] an L-alanyl-[tRNA Ala ] an L-lysyl-[tRNA Lys ] an L-cysteinyl-[tRNA Cys ] an L-glutamyl-[tRNA Glu ] an L-tryptophanyl-[tRNA Trp ] an L-glutaminyl-[tRNA Gln ] an L-isoleucyl-[tRNA Ile ] an L-tyrosyl-[tRNA Tyr ] an L-aspartyl-[tRNA asp ] an L-leucyl-[tRNA Leu ] an L-histidyl-[tRNA His ] a glycyl-[tRNA Gly ] pyruvate 3-methlbutanol xylitol [elongator tRNA Met ] [initiator tRNA Met ] [tRNA Phe ] 5-oxo-L-proline Unknown: SOR2 a CCXX sequence a XXCC sequence YMR215W kinase: PYK2 pro sorbitol dehydrogenase: ADH3 3-methylbutanol Xylitol pyruvate protein 3-methylbutanol IPP dehydrogenase: dehydrogenase: DMAPP kinase: CDC19 NEDDylation 5-oxoprolinase YLL055W dehydrogenase: ADH2 YKR013W (ATP-hydrolysing) SOR1 XYL2 [+ 2 isozymes] keto-D-fructose D-xylulose pyruvate : OXP1 proline an apo-[LYS2 L- a protein that a (3R)-3- 1-palmitoylglycerone (S)-1-pyrroline- a [NEDD8] C- tryptophan degradation coenzyme A an L-arginyl- H 2 O (2E,6E)-farnesyl an L-asparaginyl- canavaninosuccinate a uridine 65 in tRNA a phytosphingosine L-phenylalanine 2-aminoadipyl- a protein diphosphate ends with a a palmitoylated protein hydroxyoctadecanoyl- Ins(1,4,5)P 3 Ins(1,4,5)P 3 cys 5-carboxylate dimethylallyltransferase: VIII (to tryptophol) 3-methylbutanol degradation [tRNA Arg ] [tRNA Asn ] 3-phosphate bifunctional DRAP ADP terminal glycine diphosphate γ YMR307W ERG20 E1 NEDD8- degradation III carrier-protein] CaaX sequence [acp] deaminase/tRNA L-glutamate - sphinganine Nucleoside and Nucleotide Biosynthesis glu L-cysteine xylulokinase: XKS1 (3R)-3- 1-acyl inositol activating enzyme: ARGRIII inositol pseudouridine bifunctional AP-4-A semialdehyde kinase: LCB3 an [E1 NEDD8- degradation II dihydroxyacetone polyphosphate 5- cystathionine beta- UBA3 ULA1 holo-[LYS2 peptidyl- hydroxyacyl-[acyl- polyphosphate phosphorylase/ADP dehydrogenase: sphinganine tRNA-uridine 2-thiolation trp pro inorganic phosphate synthase: RIB2 YKL164C activating enzyme]- β D-xylulose Peptidyl-Trna argininosuccinate carrier-protein] tRNA phosphatase: INP54 synthase: CYS4 superpathway of purine palmitate geranyl diphosphate (yeast mitochondria) phe -D-fructofuranose carrier-protein] arginyl- pyrophosphatase: protein multikinase: ARG82 [+ 3 isozymes] sulfurylase: APA2 PUT2 kinase: YSR3 RAX2 pyrimidine Fatty Acid and Lipid Biosynthesis S-[NEDD8 protein]- proline Hydrolase: PTH1 palmitoyl-(protein) dehydratase: HTD2 reductase: AYR1 65 de novo biosynthesis pyrimidine pyrimidine dTMP de novo superpathway of ergosterol biosynthesis I very long superpathway phosphatidate phosphatidylglycerol dolichol and L-tryptophan:phenylpyruvate L-tryptophan:2-oxoglutarate 5-phosphate synthase: LYS5 tRNA-protein farnesyltransferase: lyase: ARG4 pseudouridine ADP- nucleotides de novo biosynthesis I UMP biosynthesis II biosynthesis dehydrogenase: PPA2 aminoacyl-tRNA hydrolase: TML25 D-myo-inositol a phytosphingosine ribonucleosides deoxyribonucleotides nucleobases biosynthesis chain fatty acid biosynthesis (yeast) biosynthesis II dolichyl phosphate cardiolipin yl-L-cysteine L-phenylalanine:pyruvate L-phenylalanine:2-oxoglutarate cys Phosphopantetheine:Protein transferase: ATE1 inorganic RAM2 RAM1 1-palmitoyl-sn- synthase: PUS1 sulfurylase: APA1 YNL087W of pyrimidine (cytoplasm) ω E2 NEDD8- aminotransferas: ARO9 aminotransferase: ARO8 fructokinase: HXK2 hydrolase: PTH2 a (2E)-octadec- 1,3,4,5,6- a pseudouridine 65 Ins(1,4)P 2 glu de novo biosynthesis I biosynthesis ,E,E-farnesyl glyoxylate cycle (S)-1-pyrroline-PUT1 aminotransferase: ARO9 aminotransferase: ARO8 cystathionine Transferase: PPT2 diphosphatase: IPP1 glycerol 3-phosphate ser APS 1-phosphate ribonucleotides salvage III salvage II (mitochondrial) biosynthesis (non-plastidic) biosynthesis conjugating cys fructokinase: HXK1 2-enoyl-[acp] diphosphate (indol-3-yl)pyruvate gamma- pentakisphosphate in tRNA PRPP an acetoacetyl-[acp lanosterol 5-carboxylate 3-phenyl-2-oxopropanoate cytidine UDP CTP cytosine synthase: ERG20 an [E2 NEDD8-enzyme: UBC12 domain within a DHAP DHAP (2E,6E)-farnesyl a CDP- lyase: CYS3 a farnesylated L-canavanine fumarate YKL163W gln hydrogencarbonate UDP reductase: nucleoside- a 7,8-dihydrofolate stearoyl-CoA 3-(indol-3-yl)pyruvate carboxy-lyase: ARO10 L-cysteine a holo-[LYS2 L- an N-terminal guanine guanine gln cytidine cytosine dihydrofolate fatty acid synthase] diphosphate diacylglycerolCDP-diacylglycerol-- succinate acetyl-CoA conjugating L-cysteine F6P 3’,5’-ADP protein that palmitate RNR2 RNR4 RNR1 triphosphatase: FAP7 3-oxo-arachidoyl- cis-prenyltransferase: (2E,6E)-farnesyl phenylpyruvate carboxy-lyase: ARO10 2-aminoadipyl- a tRNA Arg H + asn tRNA Asn a protein phosphoribosylpyrophosphate ribonucleoside- reductase: DFR1 enzyme]-S- indole-3-pyruvate carboxy-lyase: PDC6 2-aminoprop-desulfidase: IRC7 arginyl-[protein] phosphate hypoxanthine hypoxanthine carbamoyl nucleosidase: URH1 CTP diphosphatase: deaminase: FCY1 glycerol-3-phosphate glycerol-3-phosphate 3- desulfurase: phenylpyruvate carboxy-lyase: PDC1 ends with a YLR187W YER056C amidotransferase: ADE4 CoA synthase: ELO2 glycerol 3- dihydroxyacetone NUS1 SRT1 diphosphate indole-3-pyruvate carboxy-lyase: PDC5 2-enoate carrier-protein] adenine adenine cytosine diphosphate YND1 uracil thymidylate 3-oxo-arachidoyl- dehydrogenase: GUT2 cis-prenyltransferase: phosphatidyltransferase: [NEDD8-protein]- indole-3-pyruvate carboxy-lyase: PDC1 phenylpyruvate carboxy-lyase: PDC5 CaaX sequence phosphate carbamoyl phosphate phosphate 1-(3-sn- glyoxylate NFS1 ISD11 cytosine cytosine reductase: CDP synthase: CDC21 di-trans, poly- yl-L-cysteinecullin-RING- phenylpyruvate carboxy-lyase: PDC6 synthase: URA2 phosphate CoA synthase: ELO3 NUS1 RER2 PGS1 malate synthase: MLS1 an [L-cysteine 5-phospho-β- gly carbamoyl uracil 3-oxoicosanoyl-CoA dehydrogenase: oleoyltransferase: sn-glycerol 3-phosphate phosphatidyl) farnesyltranstransferase: type E3 NEDD8 L-glutamate-5- cytosine RNR1 RNR3 cis-polyprenyl a uridine 34 desulfurase]-S- (indol-3-yl)acetaldehyde an [apo BCAA synthase: URA2 CDP reductase: 30-hydroxylanosterol GPD1 SCT1 -sn-glycerol isocitrate lyase:malate ICL1 synthase: DAL7 in tRNA semialdehyde phenylacetaldehyde D-ribosylamine phosphate phosphoribosyltransferase: a 5,10- dihydroxyacetone diphosphate (C ) BTS1 transferase: a 2,3,4-saturated 2-(2-carboxy-4- 1-phosphatidyl- guanosine YKL096W deaminase: FCY1 RNR2 RNR4 RNR2 RNR4 RNR1 a (3R)-3-hydroxybutanoyl- [+ 2 isozymes] 80 sulfanyl-L-cysteine a 1-palmitoyl-2- a (3R)-3- dehydrogenase YNL180C dUDP ribonucleoside- FUR1 a tetrahydrofolate glycerol-3-phosphate-O- 3-phosphate cysteine γ CDP-choline an MPP-processed a peptide with a O-succinyl- urea-1-carboxylate a uridine 13 in tRNA a 1-alkyl-glycerone an α factor a sphingoid base methylenetetrahydrofolate [acp domain within 3-oxo- phosphate RTT101 MMS1 indole-3-ethanol:NAD+ oxidoreductase: SFA1 L-glutamate - 1,2-diacyl-sn- HMP-PP methylthiazol-5- hydroxyacyl-[acyl- 1D-myo-inositol 2’,3’-cyclic Ins(4)P E2 protein] N 6 aspartate acyltransferase: GPT2 2-phenylethanol:NAD+ oxidoreductase: SFA1 acyl-sn-glycerol bifunctional DRAP 3-phosphate a sphingolipid YPL006W a sphingolipid carbamoyl uracil diphosphate UMP arachidoyl-CoA HRT1 ESC2 5-carboxymethylaminomethyluridineuridine- desulfurase:TUM1 indole-3-ethanol dehydrogenase: ADH5 CTP mitochondrial protein penultimate glycine yl)ethyl phosphate L-homoserine phosphoribosylglycinamidine asp a fatty acid synthase] acyltransferase: a [cullin]-N 6 semialdehyde 2-iminopropanoate glycerol 3-phosphate carrier protein] 3,4,5-trisphosphate monophosphate 1D-myo-inositol -dihydrolipoyl- carbamoyltransferase: glycerol-3-phosphate 1- phosphatidylglycerophosphatase: GEP4 GGPP - sulfurtransferase: indole-3-ethanol dehydrogenase: ADH4 2-phenylethanol dehydrogenase: ADH5 deaminase/tRNA sphinganine phosphate dUDP kinase: YNK1 reductase: reductase: IFA38 sn-glycerol GPT2 [tRNA] synthase: MSS1 MTO1 dehydrogenase: (3R)-3- 2’,3’-cyclic- BARrier to the synthetase: ADE5,7 O-acyltransferase: SCT1 [NEDD8-protein]- indole-3-ethanol dehydrogenase: ADH3 2-phenylethanol dehydrogenase: ADH4 acylglycerone- 4-monophosphate L-lysine URA2 RNR1 RNR3 3-phosphate a [3-TUM1 TEnsin-like nucleotide 3’- pseudouridine dihydrolipoamide alpha factor kinase: YSR3 serine fatty acid biosynthesis indole-3-ethanol dehydrogenase: ADH2 PUT2 2-phenylethanol dehydrogenase: ADH3 diacylglycerol bifunctional hydroxyacyl-[acyl- phosphatase: INM1 sphinganine (3R)-3-hydroxy- a 1-acyl-sn- D-threo-isocitrate (S)-malate yl-L-lysine mercaptopyruvate phosphatidate synthase: RIB2 phosphate INositol dehydrogenase: dUTP RNR2 RNR4 hydroxymethyltransferase: a di-trans, poly- an L-1-phosphatidyl- initiation (animals a 5-carboxymethylaminomethyluridine 34 indole-3-ethanol dehydrogenase: ADH1 2-phenylethanol oxidoreductase: ADH2 cholinephosphotransferase: allophanate carrier-protein] Phosphatase: TEP1 phosphodiesterase: tRNA response: BAR1 YPL060W N-carbamoyl- aspartate arachidoyl-CoA 1-oleoyl-2-lyso- hydroxyethylthiazole cystathionine reductase: AYR1 kinase: LCB3 Mg 2+ Mg 2+ YJR150C YNL257C GAR 30-oxolanosterol glycerol 3-phosphate cis-polyprenol sn-glycerol in tRNA sulfurtransferase]-S glu 2-phenylethanol dehydrogenase: ADH1 cytidylyltransferase: CDS1 octapeptidyl amino- carboxypeptidase: CPD1 Monophosphatase: LPD1 carbamoyltransferase: dCDP SHM2 glycerol-3- and fungi, cytoplasm) EPT1 putative phosphatidate kinase/thiamine- hydrolase: DUR1,2 dehydratase: HTD2 pseudouridine 13 an [apo BCAA L-aspartate dUTP glycine glycerone phosphate -sulfanyl-L-cysteine diacylglycerol gamma- a 1-phosphatidyl- a sphingoid a (2E)-but-2-enoyl- 3-hydroxy- lysophosphatidic acid malate indole-3-ethanol cytidylyltransferase: peptidase: OCT1 CPS1 guanosine 2’- synthase: PUS7 a 1-alkyl-sn- INM2 URA2 pyrophosphatase: phosphate 1-O- aconitate hydratase: ACO2 cholinephosphotransferase: phosphate synthase: STR2 a trans-2-enoyl- dehydrogenase a peptide hydroxymethyltransferase: [acp domain within arachidoyl-CoA polyprenol cardiolipin dehydrogenase: MAE1 2-phenylethanol 1D-myo-inositol a pseudouridine 13 myo-inositol 1-phosphate phosphoribosylglycinamide dCDP kinase: YNK1 oleoyltransferase: acyltransferase: LOA1 acetyl-CoA acetyl-CoA aconitate hydratase: ACO1 tRNA-5- pyruvate TAM41 diphosphorylase: THI6 monophosphate glycerol 3-phosphate E2 protein] N 6 - iron(III)- iron(III)- DUT1 superpathway of purine nucleosides salvage SHM1 1-acyl lysophosphatidic acid [+ 2 isozymes] CPT1 [acyl-carrier protein] 4,5-bisphosphate in tRNA dihydrooratase: [+ 3 isozymes] a fatty acid synthase] dehydratase: PHS1 reductase: DFG10 synthase: CRD1 mRNA carboxymethylaminomethyluridine lipoyl-L-lysine YOL158C formyltransferase: ADE8 glycerol-3-SCT1 acyltransferase: ICT1 tyrosine degradation enterobactin enterobactin URA4 N-carbamoyl- dihydroxyacetone acetyl-CoA capping 2-sulfurtransferase: SLM3 D-serine trans-arachido- 1-acyl-sn-gylcerol- acetyl-CoA:[acyl- ammonium CO 2 complex complex L-aspartate dUMP dCTP α phosphate O- phosphate carboxylase: ACC1 cis-aconitate oxaloacetate CMP a CDP-2,3,4-saturated- a fully-processed a peptide with a YNL294C 4,4-dimethyl-5- -cholesta- 3-phosphate acyl a dolichol carrier protein] degradation a 1-palmitoyl-2-acyl-sn- succinate YJR004C 2-enoyl-CoA acyltransferase: reductase: AYR1 Ptd 2 Gro acetyl-coenzyme an octapeptide an amino acid thiamine phosphate L-homocysteine FGAR pyrimidine 8,14,24-trien-3-β-ol a 5’-triphospho- a 5-carboxymethylaminomethyl- L-serine glycero-3-phosphocholine diacylglycerol mitochondrial protein C-terminal glycine (S)-dihydroorotate thymidylate adenine GPT2 transferase: SLC1 A carboxylase, transacylase: FAS1 deoxyribonucleotides trans-arachidon- aconitate hydratase: ACO1 purine-[mRNA] tyr degradation an oxidized dihydrooratase: synthase: CDC21 a 1,2-diacyl-sn- mitochondrial: HFA1 polynucleotide 5’- 2-thiouridine 34 in tRNA a butanoyl-[acp C-14 sterol 2-enoyl-CoA dolichol an acetyl-[acp aconitate hydratase: ACO2 O 2 c-type phosphoribosylformylglycinamidine URA4 biosynthesis from CTP phosphatase: CTL1 D-serine L-threonine dihydroorotate guanine domain within a glycerol 3-phosphate kinase: SEC59 domain within a L-tyrosine:2-oxoglutarate L-tyrosine:pyruvate cytochrome synthetase: ADE6 dTMP reductase: ERG24 reductase: TSC13 malonyl-CoA mRNA 5’- degradation IV Cco dehydrogenase: CTP inosine fatty acid synthase] fatty acid synthase] aminotransferase: ARO8 aminotransferase: ARO9 a [pyruvate a reduced putative phosphatidate triphosphate ser D-serine a 1-arachidonoyl- a peptide with a 1-phosphatidyl- adenosine a [protein] (L- YNR049C URA1 citrate synthase: CIT2 a sulfurated a peptide with a an oxidized a uridine 32 in tRNA dehydrogenase E1 roseoflavin (S)-dihydroorotate arachidoyl-CoA dehydratase: DSD1 CDP-choline hydrogen cyanide 1D-myo-inositol 2’,3’-cyclic serine/L-threonine) H 2 O c-typean oxidized YJL174W nucleoside- thymidylate adenine cytidylyltransferase: a diphospho-5’-phosphatase: CET1 3-(4-hydroxyphenyl)pyruvate 2-acyl-sn-glycerol an N-terminal ser a tRNA sec glu ala a ferricytochrome b 5 D-serine L-2-aminoadipate orotate adenine 14-demethyllanosterol a dolichyl phosphate [sulfur carrier] leader sequence hemoprotein bifunctional DRAP α subunit]-L-serine mitochondrial FGAM triphosphatase: FAP7 phospholipid remodeling citrate L-serine 2-aminoprop- 3,4-bisphosphate monophosphate phosphateprotein-serine/ O 2 cytochromec-type kinase: CDC8 adenosine aminohydrolase: 1-oleoyl-sn- TAM41 acetoacetyl-[acp] acetyl-CoA purine-3’-[mRNA] N 6 -L-threonylcarbamoyladenosine 37 thr Xaa-L-proline dihydroorotate CTP diphosphatase: guanine phosphoribosyltransferase: inosine 3-oxo-behenoyl- phosphatidate (phosphatidylcholine) deaminase: CHA1 2-enoate 2’,3’-cyclic- deaminase/tRNA Protein Kinase respiratory cytochrome orotate AAH1 glycerol 3-phosphate synthase: FAS2 -modified tRNA biosynthesis 4-hydroxyphenylpyruvate threonine riboflavin phosphoribosyltransferase: APT1 4,4-dimethylzymosterol,NAD(P) CoA synthase: ELO2 cytidylyltransferase: CDS1 2-aminoprop- NADH-cytochrome TEnsin-like nucleotide 3’- pseudouridine chain complex phosphoribosyltransferase: dehydrogenase: YND1 dTDP adenine phosphorylase: mRNA carboxy-lyase: PDC6 diacylglycerol NADPH--hemoprotein D-serine L-2-aminoadipate phosphatase: of PDH: PKP1 a reduced phosphoribosylformylglycinamidine a 3-oxohexanoyl- H:oxygen oxidoreductase 3-oxo-behenoyl- acyl-CoA:lyso- 4-hydroxyphenylpyruvate 2-enoate b reductase: CBR1 synthase: RIB2 [+ 4 isozymes] kinase: FMN1 URA1 guanine HPT1 PNP1 1,2-dipalmitoyl-sn- guanylyltransferase: cholinephosphotransferase: thiosulfate signal peptidase serine--tRNA 5 reductase: NCP1 Phosphatase: TEP1 phosphodiesterase: tRNA dehydratase: DSD1 reductase: LYS2 CDC55 H 2 O IV variant 2 c-type URA5 CDP xanthine phosphoribosyltransferase: CoA synthase: ELO3 phosphatidate a CDP-diacylglycerol an acetoacetyl-[acp L-threonine [+ 3 isozymes] Zn 2+ cyclo-ligase: ADE5,7 orotate PRPP [acp domain within (hydroxylating): ERG25 carboxy-lyase: PDC1 sulfurtransferase: aminopeptidase complex subunit: glutamate--cysteine CPD1 a [pyruvate YNR070W deaminase: GUD1 APT2 glycero-3-phosphocholine CEG1 EPT1 ligase: DIA4 pseudouridine 32 TPD3 PPH22 Zn 2+ Zncytochrome2+ orotate dTDP kinase: YNK1 phosphoribosyl adenosine α β acyltransferase: domain within a thr aldolase: GLY1 diacylglycerol a 1-phosphatidyl- transporter YJL160C phosphoribosyltransferase: CDP reductase: a fatty acid synthase] 4 -hydroxymethyl-4 - CDP-diacylglycerol-- a 5’-(5’- RDL1 yscII: APE2 SPC3 SPC1 serine--tRNA ligase: GSH1 [+ 28 isozymes] dehydrogenase roseoflavin transferase: XPT1 kinase: ADO1 3-oxobehenoyl-CoA fatty acid synthase] synthase: PUS9 URA10 RNR2 RNR4 RNR1 hypoxanthine methyl-5α-cholesta- ALE1 acyl-CoA:lyso- (4-hydroxyphenyl)acetaldehyde cholinephosphotransferase: ligase: SES1 a reduced 1D-myo-inositol 2’-AMP a pseudouridine 32 pyruvate allysine a [protein] Ser/Thr E1 α subunit]-L- 5’-phosphate AIR oleoyl-CoA: glycerol-3-phosphate 3- triphosphoguanosine) L-threonylcarbamoyladenylate SEC11 SPC2 a ferrocytochrome b 5 orotate ribonucleoside- β 2-iminopropanoate CPT1 hemoprotein dTTP 8,24-dien-3α -ol β lysophosphatidate phosphatidylcholine -purine-[mRNA] 4-phosphate in tRNA serine phosphate orotidine 5’- phosphoribosyltransferase: diphosphate 4 -hydroxymethyl-4 - 3-oxo- phosphatidyltransferase: synthase: SUA5 tyrosol dehydrogenase: ADH5 a basic a basic acyltransferase: ALE1 acetaldehyde gly YKR105C methyl-5α-cholesta- acyltransferase: PGS1 mRNA (guanine-N 7 ) (L-threonylcarbamoyl) tyrosol dehydrogenase: ADH4 an unsulfurated phosphoribosylaminoimidazole phosphate URA5 reductase: behenoyl-CoA lyso-phosphatidylcholinephospholipase A2: TGL4 2-iminopropanoate thiocyanate γ-L-glutamyl- amino acid amino acid orotate GMP AMP 8,24-dien-3β-ol,NAD(P) TGL4 -methyltransferase: adenylate tyrosol dehydrogenase: ADH3 a 1-arachidonoyl- CMP [sulfur carrier] a proteinogenic a peptide with an N- YOL002C carboxylase: ADE2 RNR1 RNR3 xanthine hypoxanthine a (3R)-3-hydroxyhexanoyl- reductase: IFA38 oleoyl- 1-(3-sn-phosphatidyl)- acyltransferase: TAZ1 a peptide an L-seryl-[tRNA sec ] D-alanine phosphoribosyltransferase: ABD1 tyrosol dehydrogenase: ADH2 2-acyl-sn-glycero- a leader sequence YJL159W orotidine-5’- RNR2 RNR4 H:oxygen oxidoreductase (3R)-3- 7 N 6 -L- amino acid terminal L-proline phosphoribosyltransferase: [acp domain within CoA:lysophosphatidate sn-glycerol 3-phosphate a 5’-(N -methyl 5’- tyrosol:NAD+oxidoreductase: ADH1 phosphate URA10 (hydroxylating): ERG25 hydroxybehenoyl- threonylcarbamoyladenine 3-phosphocholine asp dCDP HPT1 a fatty acid synthase] acyltransferase: TGL5 phosphatidylserine and triphosphoguanosine)- a pentapeptide a pentapeptide CAIR decarboxylase: xanthine xanthine 4α-formyl-4β-methyl-5α- oleoyl- synthase: KAE1 BUD32 glutamate YPR194C CoA 1-palmitoyl-sn-glycero- phosphatidylethanolamine (purine-ribonucleotide) 4-tyrosol pyruvate a tetrapeptide a tetrapeptide phosphoribosyl AMD1: AMD1 phosphoribosyl β CoA:lysophosphatidate a phosphatidylcholine degradation URA3 orotidine 5’- cholesta-8,24-dien-3 -ol 3-hydroxy- phosphatidylglycerophosphatase: GEP4 3-phosphocholine phospholipid: lyso- biosynthesis I -[mRNA] CGI121 GON7 PCC1 acetyl-CoA acyltransferase: SLC1 putative N(6)-L- an 1-acyl-2- a 5’-half-tRNA (R)-N-formyl- (3R,5S)-3-hydroxy- a [mitogen- UMP dCDP kinase: YNK1 transferase: XPT1 transferase: XPT1 4α-formyl-4β-methyl- behenoyl-CoA to 2- a 3’-half-tRNA a (3R)-3- a ribonucleoside a 1,2-diacyl- phosphate lysophosphatidic phosphatidylcholine threonylcarbamoyladenine pyruvate arachidonoyl- molecule with β long chain 1-pyrroline- a [protein]-L-tyrosine YOL020W phosphoribosylaminoimidazolesuccinocarboxamide α a CDP- oxoglutarate CDP-choline NADPH an oxidized glutathione molecule with -hydroxy- 2’,3’-cyclic activated protein cys L-homoserine bifunctional 5 -cholesta-8,24-dien- dehydratase: PHS1 acid acyltransferase: a phytochelatin a tRNA precursor hydroxytetradecanoyl- a ferrihemoglobin polyphosphate sn-glycerol an L-1-phosphatidyl- acyltransferase: TAZ1 synthase: QRI7 sn-glycerol adrenodoxin a 2’,3’-cyclic L-kynurenine 5-carboxylate kinase]-L-threonine YEL063C YJL158C synthase: ADE1 orotidine-5’- 3β-ol,NAD(P)H:oxygen Lecithin cholesterol diacylglycerol an N 6 -L- a 5’-OH end [acp] phosphate L-canavanine L-canavanine thymidylate/ a (2E)-hex-2-enoyl- ICT1 sn-glycerol phosphate end Mitogen- dCTP dCMP trans-docos- oleoyl-CoA: (3R)-3- 2’,3’-cyclic- pyrroline-5- tyrosine protein L-cysteine phosphate oxidoreductase acetyl-CoA acyl transferase: LRO1 phosphatidylserine threonylcarbamoyladenine 37 glu diacylglycerol uridylate XMP IMP [acp domain within 2-enoyl-CoA NADH-cytochrome PPN1: PPN1 nucleotide 3’- activated Kinase desulfidase: IRC7 cystathionine decarboxylase: pyrimidine lysophosphatidate synthase: CHO1 NAD-dependent asparagine L-phenylalanine degradation I (aerobic) diacylglycerol hydroxyacyl-[acyl- carboxylate kinase: MPS1 kinase: CDC8 a fatty acid synthase] α (hydroxylating):β ERG25 phosphatidylethanolamine in tRNA phytochelatin exopolyphosphatase: Kinase: MKK2 cystathionine kinase: DGK1 gamma- a 3-sn- Ups2-Mdm35 a 3-sn- SAICAR deoxycytidylate 4 -carboxy-4 - acetyl-CoA C- glutamate b 5 reductase: CBR1 phosphodiesterase: reductase: PRO3 [+ 3 isozymes] UMP kinase: URA6 URA3 deoxyribonucleotide trans-docosan- acyltransferase: biosynthesis II a 3-sn-phosphatidyl- degradation L-glutamate cholinephosphotransferase: adrenodoxin-NADP arylformamidase: carrier-protein] PPX1 [+ 3 isozymes] α synthase: PRC1 [+ 3 isozymes] gamma- lyase: CYS3 + YNL321W Na + phosphatidyl- phosphatidylserine phosphatidyl- deaminase: DCD1 methyl-5 -cholesta- acyltransferase: POT1 dehydrogenase: EPT1 CPD1 Na 5’-phosphoribosyl-4-(N- UMP phosphorylation 2-enoyl-CoA LOA1 L-serine degradation to 4- reductase: ARH1 phytochelatin tRNase Z: TRZ1 tRNA ligase: TRL1 BNA7 dehydratase: HTD2 a [mitogen-activated lyase: CYS3 L-serine transporter L-serine UDP 8,24-dien-3β-ol acetyl-CoA diacylglycerol a [protein]-L- 4α-carboxy-4β-methyl- bisoleoyl GDH2 a 4a-hydroxytetrahydropteridine long chain a ribonucleoside a 1,2-diacyl-sn- YJL132W succinocarboxamide) dUMP dTMP dCMP acetyltransferase: ERG10 reductase: TSC13 a 1-acyl-sn-glycero- phosphatidylserine 2-oxoglutarate aminobutanoate cholinephosphotransferase: synthase: ATG42 a (2E)-tetradec- Hyp protein kinase] L- pyruvate 2-oxobutanoate 5α-cholesta-8,24- phosphatidate a ferrohemoglobin polyphosphate 2’-phosphate tyrosine phosphate glycerol 3-phosphate -5-aminoimidazole stearate ser asn 2-enoyl-[acp] threonine phosphate thymidylate β 3-phosphocholine decarboxylase: PSD1 CPT1 lyase: ADE13 UDP kinase: YNK1 adenine and a hexanoyl-[acp dien-3 -ol:NAD(P) acetoacetyl-CoA docosanoyl-CoA biosynthesis phosphatidylserine Na + YLR138W Na + thymidylate kinase: CDC8 asparaginase: glu β YOR008C adenosine superpathway guanine and domain within a + 3-oxidoreductase decarboxylase: PSD2 NADP + H + a reduced (R)- -hydroxy- formate AICAR synthase: CDC21 adenine and ASP3-4 a 1-acyl-2- CMP gly a phytochelatin a single-stranded a 2’-phospho- UTP salvage VI of pyrimidine guanosine dTDP dCDP fatty acid synthase] (decarboxylating): ERG26 a palmitoyl-[acp an L-1- [+ 4 isozymes] glutamate adrenodoxin mature tRNA L-kynurenine superpathway adenosine salvage IV hydroxymethylglutaryl- 3-oxo-lignoceronyl- arachidonoyl- oligoribonucleotide [ligated tRNA] dTMP nucleobases salvage salvage 3-dehydro-4- domain within a phosphatidylethanolamine 4a-hydroxy-L- decarboxylase: phosphoribosylaminoimidazolecarboxamide CTP synthase: of adenosine asp a 5,6,7,8- phosphatidylcholine YJL079C methylzymosterol CoA synthase: ERG13 CoA synthase: ELO3 erythro-5,6,7,8- GAD1 Na + YDR039C Na + formyltransferase: ADE16 dTDP kinase: YNK1 dCDP kinase: YNK1 phosphatidylcholine fatty acid synthase] alanine tetrahydropteridine URA8 nucleotides adenosine uracil tetrahydrobiopterin 4-aminobutanoate phosphoribosylaminoimidazolecarboxamide CTP synthase: thymidylate uracil 3-keto-4- biosynthesis I glycerol degradation III de novo adenine 3-oxolignoceroyl- ethanolamine DNA combined YOR047C formyltransferase: ADE17 URA7 kinase: CDC8 guanosine methylzymosterol HMG-CoA a 3-oxooctadecanoyl- biosynthesis α a farnesylated biosynthesis I phosphoribosyltransferase: dTTP dCTP CoA 4 -hydroxytetrahydrobiopterin 1,2-dipalmitoyl- a (3R)-3- a (3R)-3- with exogenous β-D-glucose adenosine a 3-oxooctanoyl- reductase: ERG27 [acp domain CDP-choline thiosulfate (glutathion-S-yl)-bimane glycerophosphoglycerol protein that a RNA-DNA hybrid a uridine in rRNA ethanol a [protein] Ser/Thr cholesterol a small peptide sphingosine FAICAR CTP dTDP FUR1 choline bifunctional choline kinase/ dehydratase: MCO14 sn-glycerol O-acetyl-L-serine hydroxyhexadecanoyl- hydroxydodecanoyl- DNA to form a 6-phosphate Na + YDR038C Na + kinase: ADO1 UMP guanosine [acp domain within 3-hydroxy-3methylglutary- 3-oxo- within a fatty ala Polymeric Compound Degradation ends with a medium-chain fatty sterol O- dipeptidyl IMP α α bifunctional choline ethanolamine kinase: CKI1 DHAP oleate (6R)-L-erythro [acp] [acp] recombinational asp a fatty acid synthase] 4 -methyl-5 -cholesta- CoA reductase: HMG2 lignoceroyl-CoA acid synthase] serine/threonine sphinganine YJL078C inosine adenine bifunctional thymidylate/ phosphorylase: PNP1 3-hydroxy-3- ethanolamine kinase: EKI1 glycerol 3- biosynthesis transaminase: ALT2 L-erythro-7,8- CaaX sequence (3R)-3- (3R)-3- rRNA pseudouridine acid ethyl ester acyltransferase: aminopeptidase: AMP adenine 8,24-dien-3β-ol kinase/ethanolamine alanine -5,6,7,8- junction inositol-3-phosphate protein kinase: kinase: LCB3 dTDP kinase: YNK1 reductase: IFA38 phosphate dihydrobiopterin chitin TOPoisomerase: synthase: EHT1 ARE2 DAP2 monophosphate phosphoribosyltransferase: aminohydrolase: AAH1 uridylate kinase: CDC8 methylglutaryl-CoA kinase: EKI1 tetrahydrobiopterin diacylglycerol (glutathion-S-yl)-bimane phosphatidylglycerol hydroxyacyl-[acyl- hydroxyacyl-[acyl- synthase: NOP10 synthase: INO1 medium-chain fatty sterol O- dipeptidyl sphinganine a tetrapeptide a tetrapeptide UMP kinase: URA6 guanine α (3R)-3- choline kinase: CKI1 aminotransferase: glycogen degradation II prenyl protein- RNase H: RNH70 TOP3 SGS1 RMI1 PHO80 PHO85 YJL212C YOR101W cyclohydrolase: APT1 4- -methylzymosterol,NAD(P) reductase: HMG1 O-phosphoethanolamine dehydrogenase: degradation cholinephosphotransferase: cysteine carboxypeptidase: ATG42 phospholipase C: PGC1 carrier-protein] carrier-protein] CBF5 GAR1 NHP2 [+ 127 isozymes] acyltransferase: aminopeptidase: a pentapeptide adenine hydroxylignoceroyl- phosphocholine stearoyl-CoA ALT1 RNase H: RNH203 [+ 2 isozymes] acid ethyl ester kinase: YSR3a pentapeptide ADE16 adenylosuccinate dTTP H:oxygen oxidoreductase GPD1 pyruvate to ethanol EPT1 (glutathion-S-yl)-bimane glycerophosphodiesterase: specific dehydratase: HTD2 dehydratase: HTD2 resolution of inosine UDP a (3R)-3- diacylglycerol synthase: MCY1 RNH202 RNH201 synthase: EEB1 a [protein] (L- ARE1 STE13 synthetase: ADE12 phosphoribosyltransferase: guanine (hydroxylating): ERG25 (R)-mevalonate CoA [+ 2 isozymes] carboxypeptidase: PRC1 GDE1 endoprotease: a pseudouridine a long-chain acyl- sphingosine monophosphate a (3R)-3-hydroxyoctanoyl- hydroxyoctadecanoyl- sn-glycerol stearoyl-CoA 9- a glycogen recombinational Ins(3)P ethyl octanoate serine/L-threonine) a dipeptide APT2 hypoxanthine phosphoribosyltransferase: 3-hydroxy- phosphoethanolamine chitin cholinephosphotransferase: a (2E)-hexadec- a (2E)-dodec- in rRNA cholesterol ester 1-phosphate α α choline-phosphate 3-phosphate desaturase: OLE1 STE24 junction formation YIL169C cyclohydrolase: [acp domain within 4 -hydroxymethyl-5 - lignoceroyl-CoA [acp domain within cytidyltransferase: ECT1 chitin deacetylase: CPT1 2-enoyl-[acp] 2-enoyl-[acp] phosphate UDP kinase: YNK1 HPT1 of two intact strands an amino acid YKR039W an amino acid ADE17 xanthine phosphoribosyl a fatty acid synthase] cholesta-8,24-dien-3β-ol cytidylyltransferase: PCT1 a fatty acid synthase] glycogen adenylo-succinate mevalonate kinase: ERG12 dehydratase: PHS1 a 1,2-diacyl-sn-glycerol oleoyl-CoA CDA1 (γ-glutamylcysteine- glycerol hypoxanthine α α CDP-ethanolamine acetate sn-glycerol a [protein] C- DNA a nucleoside 5’- YOR129C superpathway of transferase: XPT1 4 -hydroxymethyl-5 - chitin deacetylase: phosphorylase: 1,2-dipalmitoyl- S-sulfo-L-cysteine S-yl)-bimane gly AMP phosphoribosyltransferase: UTP β trans-lignocer- CMP 3-phosphate terminal S- a tripeptide monophosphate guanosine nucleotides cholesta-8,24-dien-3 - CDP-choline CDA2 GPH1 sn-glycero-3- IMP adenylosuccinate HPT1 farnesyl-L-cysteine de novo biosynthesis I GMP ol,NAD(P)H:oxygen 2-enoyl-CoA acyl-CoA acetate xanthine phosphoribosyl CTP synthase: URA8 (R)-5-phosphomevalonate α phosphocholine K + YKR050W K + lyase: ADE13 oxidoreductase diacylglycerol a (2E)-octadec- ethanolaminephosphotransferase: EPT1 thioesterase: TES1 an -limit dextrin transferase: XPT1 CTP synthase: URA7 trans-lignocero- YIL123W a (2E)-oct-2-enoyl- 2-enoyl-[acp glycerol 1-phosphate acetyl CoA (hydroxylating): ERG25 2-enoyl-CoA cholinephosphotransferase: Fatty Acid and Lipid Degradation bifunctional 4-alpha- [acp domain within α α phosphomevalonate synthetase: ACS2 a [lipoyl-carrier IMP CTP 4 -formyl-5 -cholesta- CPT1 domain within a glucanotransferase/ a [mitogen- a [MAP kinase YOR322C IMP dehydrogenase: IMP reductase: TSC13 diacylglycerol oleate acetyl CoA a 1-acyl,2-oleoyl- an N-terminal L- a 2’- dihomo γ- a nucleoside protein]-N 6 -[(R) a fatty acid synthase] 8,24-dien-3β-ol kinase: ERG8 fatty acid synthase] glycerol-1- an L-arginyl- methanethiol O-succinyl- (S)-2- H O mitochondrial activated protein kinase]-(L-serine/ 3-phenylpropionitrile a D-hexose K + YJL129C K + IMD4 AMP an L-1-phosphatidylethanolamine 10-trans- amylo-alpha-1,6- CDP-choline deoxyribonucleoside 2 cyclic 3’,5’- a secondary alcohol ala ethanol α α cholinephosphotransferase: phosphatase: GPP1 9-cis, 11-trans- synthetase: ACS1 sn-glycerol aspartyl-[protein] [tRNA Arg ] [DNA] glu linolenoyl-CoA tRNA uridine 27/28 -dihydrolipoyl]- [+ 2 isozymes] 4 -formyl-5 -cholesta- lignoceroyl-CoA heptadecenoyl- 10-cis- glucosidase: GDB1 L-homoserine 5’-triphosphate aminobutanoate monophosphatehigh affinity cAMP kinase]-L-tyrosine medium-chain fatty L-threonine)mitogen- β EPT1 glycerol-1- L-lysine 8,24-dien-3 -ol,NAD(P) (R)-mevalonate CoA degradation heptadecenoyl- octadecadienoyl- oleate β- acetyl-CoA a debranched carbonyl reductase mitogen-activated acid ethyl ester hexokinase: bifunctional triacylglycerol phosphodiesterase: activated protein dihydrolipoamide IMP dehydrogenase: IMD4 H:oxygen oxidoreductase phosphatase: GPP2 CoA degradation α mitochondrial tRNA (NADPH- protein kinase alanine nitrilase: NIT1 YIL011W asp [+ 2 isozymes] diphosphate a phosphatidylcholine (reductase- CoA degradation oxidation degradation -limit dextrin diacylglycerol PDE2 synthase: EHT1 kinase kinase dehydrogenase: YLR446W Na + Na + uridylate/adenylate 3-oxo-cerotoyl-CoA (isomerase- DNA-directed 3’,5’-cyclic-nucleotide pseudouridine 27/28 dependent): ARI1 kinase: STE7 transaminase: ALT1 medium-chain fatty [+ 2 isozymes] [+ 2 isozymes] YDR456W (hydroxylating): ERG25 a stearoyl-[acp glycerol dependent) (isomerase- cystathionine alanine kinase: SSK22 LPD1 K + K + SOG2 kinase: URA6 an octanoyl-[acp mevalonate diphosphate synthase: ELO3 cholinephosphotransferase: arginyltransferase: acyl-CoA [+ 2 isozymes] [+ 3 isozymes] acid ethyl ester XMP 4α-carboxy-5α- domain within a 10-trans- 10-cis- dependent) dependent) malate debranched α gamma- DNA polymerase glutamate--cysteine phosphodiesterase, synthase: PUS2 a [MAP kinase[+ 5 isozymes] AMP kinase: ADK1 xanthine and decarboxylase: MVD1 9-cis, 11-trans- glucan 1,4- - EPT1 ATE1 thioesterase: TES1 transaminase: ALT2 synthase: EEB1 a [lipoyl-carrier domain within a β fatty acid synthase] phospholipid heptadecenoyl-CoA heptadecenoyl-CoA a triacyl-sn-glycerol synthase: MLS1 diacylglycerol alpha: POL12 POL1 low affinity: PDE1 a [mitogen-activated D-hexose adenylosuccinate xanthosine cholesta-8,24-dien-3 -ol mevalonate pyrophosphate phosphatidate limit dextrin glucosidase: SGA1 synthase: STR2 ligase: GSH1 a nucleoside 5’- kinase] (L-serine/ XMP fatty acid synthase] α α remodeling octadecadienoyl-CoA oleoyl-CoA [+ 8 isozymes] mitochondrial tRNA a ketone protein kinase] L- ethyl decanoate protein]-N 6 -[(R) 3-phenylpropanoate 4 -carboxy-5 -cholesta- decarboxylase: MVD1 3-oxocerotoyl-CoA phosphorylase: cholinephosphotransferase: pyruvate L-threonine) 6-phosphate Ca 2+ 2+ synthetase: ADE12 salvage biosynthesis II monophosphate -lipoyl]-L-lysine Ca ADP β (phosphatidate) triacylglycerol CPT1 pseudouridine 27/28 tyrosine phosphate YDL128W GDP-α-D- GDP-α-D- GMP synthase: 8,24-dien-3 -ol:NAD(P) (the glycerol-3- (S)-malate GPH1 phosphate K + K + lipase: TGL3 D-glucopyranose an N-terminal YHR211W mannose mannose + 3-oxidoreductase IPP phosphatidylinositol bisoleoyl 6-trans- 6-cis- 5-cis, 7-trans- triacylglycerol GUA1 phosphate pathway) phosphatidylcholine L-arginiyl-L- succinate di-homo-γ-linolenate adenylo-succinate (decarboxylating): ERG26 3-oxo-cerotoyl-CoA biosynthesis tridecenoyl-CoA tridecenoyl-CoA α-D-glucopyranose a tRNA Arg met γ-L-glutamyl-(S)- YGL225W ADP reductase: phosphatidate biosynthesis V tetradecadienoyl- (5Z)- lipase: TGL5 malate a 1-acyl-2-oleoyl- CMP [DNA] GMP synthase: GUA1 xanthosine reductase: IFA38 DHAP aspartyl-[protein] RNR2 RNR4 RNR1 superpathway of pyrimidine ribonucleosides salvage II (eukaryotes) CoA tetradecenoyl-CoA triacylglycerol dehydrogenase: 1-phosphate sn-glycero-3- 2-aminobutanoate GMP GMP ribonucleoside- a 3-oxodecanoyl- zymosterone stearoyl-CoA K + KHA1 K + acyl-CoA:lyso- glycerol 3-phosphate fatty acyl-CoA fatty-acyl coenzyme lipase: TGL4 MAE1 glucokinase: GLK1 phosphocholine GMP adenylosuccinate diphosphate [acp domain within IPP isomerase: IDI1 a CDP- an L-1- fatty acyl-CoA TGL1: TGL1 YPL176C (3R)-3- myo-inositol phosphatidate dehydrogenase: GPD1 oxidase: POX1 A oxidase: POX1 [+ 2 isozymes] lyase: ADE13 reductase: cytidine a fatty acid synthase] hydroxycerotoyl-CoA diacylglycerol phosphatidylethanolamine oxidase: POX1 fatty acyl-CoA [+ 3 isozymes] phosphoglucomutase: 5α-cholesta-8,24-dien- acyl-CoA acyltransferase: [+ 2 isozymes] YHR143W GMP phosphatidylethanolamine N 2-trans, 5- oxidase: POX1 pyruvate PGM1 RNR1 RNR3 xanthine a 1,2-diacyl- D-glucose D-glucose 3-one reductase: ERG27 3-hydroxy- thioesterase: TES1 ALE1 sn-glycerol 3-phosphate 2-trans-6-trans- 2-trans,6-cis- phosphoglucomutase: an N-terminal L- a 2’- a dipeptide with a cholesteryl-β- adenine 645 a [protein]-α- 2-hydroxy-2- RNR2 RNR4 DMAPP IPP oleoyl-CoA: -methyltransferase: CHO2 cis, 7-trans- an L-methionyl- an N 10 - an L-arginyl- S-methylglutathione 3-hydroxy- histidinol a phosphate (3S)-3-hydroxy- sn-glycerol phosphatidylinositol tridecadienoyl-CoA tridecadienoyl-CoA sn-glycerol pyruvate carboxy- PGM2 deoxyribonucleoside thr a [protein]-L-serine D-mannose YDL194W D-mannose GMP kinase: GUK1 cytidine deaminase: CDD1 cytidine kinase: URK1 xanthine cerotoyl-CoA lysophosphatidate tetradecatrienoyl- (2E,5Z)- formyltetrahydrofolate glutamyl-[protein] [tRNA Arg ] [DNA] C-terminal L-proline D-glucoside trifunctional histidinol in 25S rRNA monoester L-glutamate methylpropanenitrile 3-phosphate AMP synthase: PIS1 a phosphatidyl-N- [initiator tRNA Met ] 5’-triphosphate L-kynurenine L-aspartate D-fructose D-fructose dehydratase: PHS1 stearate acyltransferase: glycerol-3-phosphate-O- tetradecenoyl-CoA lyase: PDC6 dehydrogenase/ Meiotic and dADP phosphoribosyl zymosterol methylethanolamine CoA diacylglycerol pyruvate 25S rRNA glycerol-3- YPR032W a (3R)-3-hydroxydecanoyl- acyltransferase: GPT2 trans--2-enoyl-CoA trans--2-enoyl-CoA Centromere tRNA GMP kinase: GUK1 transferase: XPT1 dimethylallyltransferase: trans-cerot- TGL4 decarboxylase: kynurenine-- phosphoribosyl- (adenine645-N1)- L-threonine uridine CMP oleoyl- glycerol-3-phosphate 1- hydratase 2: FOX2 hydratase 2: FOX2 trans--2-enoyl-CoA lipase: TGL3 regulatory ser, alkaline Serine methyltransferase: phosphate bifunctional [acp domain within a 1-phosphatidyl- phosphatidyl-N- glutathione S-conjugate AMP cyclohydrolase/ deaminase: CHA1 nitrilase: NIT1 a tripeptide a tripeptide ERG20 2-enoyl-CoA CoA:lysophosphatidate dioleoyl O-acyltransferase: SCT1 hydratase 2: FOX2 PDC5 D-glucopyranose putative Xaa- β oxoglutarate methyltransferase: phosphatase: PHO8 dehydrogenase: YKR093W YHR132C GDP uridylate/adenylate a fatty acid synthase] SAM:C-24 sterol 1D-myo-inositol methylethanolamine N- pyruvate carboxy- methionyl-tRNA arginyltransferase: carboxypeptidase: ATG42 Ever Shorter cholesteryl- -D- threonine ammonia- tyr-Kinase: MCK1 Racemase: SRY1 PPM2 phosphatidate (3R)-hydroxy, (3R)-hydroxy- 6-phosphate Pro dipeptidase: transaminase: BNA3 phosphoribosyl-ATP RRP8 [+ 3 isozymes] a dipeptide a dipeptide methyltransferase: ERG6 acyltransferase: TGL5 a 1-acyl-sn- (3R)-hydroxy, 6-cis glutathione S-conjugate Telomeres: EST3 glucosidase: EGH1 lyase: ILV1 GUT2 kinase: URA6 dADP kinase: YNK1 uridine CMP kinase: URA6 XMP trans-cerot- oleoyl- methyltransferase: OPI3 6-trans- 5-cis, 7-trans- a 2-acylglycerol lyase: PDC1 formyltransferase: ATE1 YFR006W diphosphatase: HIS4 a [protein]-L- AMP kinase: ADK1 lipase: TGL4 -tridecenoyl-CoA carboxypeptidase: PRC1 4-(2-amino-3- N 1 -methyladenine 645 a [protein] L- 2-hydroxy-2- GDP nucleosidase: URH1 2-enoyl-CoA CoA:lysophosphatidate glycerol 3-phosphate tridecenoyl-CoA (3Z)-dodec- FMT1 EST2 EST1 TLC1 an alcohol glutamate-O 5 DHAP uridine kinase: DAS2 geranyl diphosphate a phosphatidyl-N- tetradecadienoyl- acetaldehyde hydroxyphenyl)- his in 25S rRNA 2-oxobutanoate serine phosphate oxaloacetate methylpropanoate reductase: TSC13 -methyl-ester YHR007C uridine kinase: URK1 uracil CDP fecosterol acyltransferase: SLC1 lysophosphatidic acid dimethylethanolamine 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA CoA 3-enoyl-CoA 2,4-dioxobutanoate lysophosphatidic 3-hydroxyacyl-CoA Ca 2+ YOR087W Ca 2+ GDP reductase: ADP phosphoribosyltransferase: uracil acyltransferase: LOA1 dehydrogenase: dehydrogenase: Δ3,Δ2-enoyl-CoA acylglycerol an N-terminal γ ω,E,E-farnesyl acid acyltransferase: alcohol -L-glutamyl-(S)- D-glucopyranose dATP FUR1 a (2E)-dec-2-enoyl- cerotoyl-CoA lysophosphatidic acid phosphatidyl-N- dehydrogenase: lipase: YJU3 an N-formyl- L-arginiyl-L- a proteinogenic cholesterol YGR189C RNR2ribonucleoside- RNR4 RNR1 FOX2 FOX2 isomerase: ECI1 dehydrogenase a tRNA Arg methyl-L-cysteine gly [DNA] pro GDP reductase: salvage pathways of pyrimidine ribonucleotides [acp domain within C-8 sterol diphosphate ICT1 acyltransferase: ICT1 dimethylethanolamine N FOX2 putative a tetrahydrofolate amino acid ADP reductase: sphingolipid biosynthesis (yeast) oleoyl-CoA: L-methionyl- glutamyl-[protein] diphosphate GDP kinase: YNK1 GDP kinase: YNK1 UMP isomerase: ERG2 synthase: ERG20 1-acyl-sn-gylcerol- 6-trans-3-oxo- 6-cis, 3-oxo- IV: ADH4 L-cystine YCR075C L-cystine RNR2 RNR4 RNR1 a fatty acid synthase] lysophosphatidate -methyltransferase: OPI3 5-cis, 7-trans-3-oxo- dodecenoyl-CoA alcohol [initiator tRNA met ] reductase: RNR2 RNR4 RNR1 ribonucleoside- 3-phosphate acyl tridecenoyl-CoA tridecenoyl-CoA glycerol Ca 2+ YNL291C Ca 2+ ribonucleoside- cytidine acyltransferase: tetradecadienoyl- isomerase: DCI1 a fatty acid dehydrogenase: RNR1 RNR3 diphosphate bifunctional thymidylate/ (2E,6E)-farnesyl transferase: SLC1 diphosphate uridylate kinase: CDC8 CDP kinase: YNK1 palmitoyl-CoA LOA1 a phosphatidylcholine CoA (2E)-dodec- ADH5 ferrioxamine B YEL065W ferrioxamine B RNR2 RNR4 reductase: RNR1 episterol diphosphate stearoyl-CoA 3-ketoacyl-CoA ethanol a dimer of adjacent reductase: UMP kinase: URA6 a 1,2-diacyl-sn- 3-ketoacyl-CoA 2-enoyl-CoA GTP RNR3 RNR2 RNR4 cytidine cytidine 3-ketoacyl-CoA dehydrogenase: an N-terminal a 1,2-diacyl- YGR037C RNR1 RNR3 serine C- glycerol 3-phosphate thiolase: POT1 thiolase: POT1 (R)-2- an L-arginyl- thymidine and ν a 1-acyl-sn-glycero- 1-chloro-2,4- a negatively succinate UDP nucleosidase: URH1 1-oleoyl-sn- thiolase: POT1 pyruvate 3-sulfo-L- 2-(glutathion-S-yl)-propene h glutathione a [protein]-L-arginine ethanol ethanol Ins(1)P lathosterone Ca 2+ YGR217W Ca 2+ deaminase: CDD1 a decanoyl-[acp C-5 sterol palmitoyltransferase: ADH3 hydroxyglutarate 2’-deoxycytidine 3-phosphocholine dinitrobenzene L-kynurenine sn-glycerol ser supercoiled DNA semialdehyde RNR2 RNR4 squalene synthase: ERG9 glycerol 3-phosphate ethanol alanyl-[protein] [tRNA Arg ] medium-chain fatty medium-chain fatty ORM1 SAC1 ORM2 4-cis- in DNA 3-diphosphatediacylglycerol YPR159W domain within a desaturase: ERG3 4-trans- dehydrogenase: protein-arginine succinate dGDP GTP uridine cytosine CMP (3Z,5E)-dodec- phosphatidylglycerol pyrophosphate acid ethyl ester acid ethyl ester dADP dGDP UDP kinase: YNK1 fatty acid synthase] TSC3 LCB1 LCB2 undecenoyl-CoA undecenoyl-CoA ADH2 kynurenine-- omega-N L-serine/L- 1D-myo-inositol TOPoisomerase: 3-keto-steroid semialdehyde phospholipid 3,5-dienoyl-CoA degradation ethanol (R)-2- Neuropathy Target phosphatase: DPP1 synthase: EEB1 synthase: EHT1 ergosta-5,7,24(28) glutathione S-conjugate glutathione medium-chain fatty medium-chain fatty 1-monophosphate 2+ YGL006W Ca 2+ squalene 3-dehydrosphinganine 3-dehydroicosasphinganine biosynthesis II oleate β- oxoglutarate diacylglycerol methyltransferase: threonine ammonia- TOP1 reductase: ERG27 dehydrogenase: Ca cytosine -trien-3β-ol fatty acyl-CoA fatty acyl-CoA putative dehydrogenase: hydroxyglutarate--pyruvate arginyltransferase: carboxypeptidase: ATG42 deoxyribodipyrimidine Esterase: NTE1 transferase: GTT2 acid ethyl ester acid ethyl ester phosphatase: INM1 UTP CMP kinase: URA6 (Kennedy pathway) oxidation glutathione S-conjugate phospholipase B: PLB2 glutathione transaminase: BNA3 diphosphate HMT1 lyase: CHA1 UGA2 YFR020W deaminase: FCY1 squalene,hydrogen- biotin-carboxyl oxidase: POX1 oxidase: POX1 dodecenoyl-CoA an L-1-phosphatidyl- ADH1 transhydrogenase: DLD2 ATE1 photo-lyase: PHR1 synthase: EHT1 synthase: EEB1 uridine (reductase- (R)-2- phospholipase B: PLB1 phosphatase: LPP1 [protein]-N ω- dGDP kinase: YNK1 isomerase: DCI1 sn-glycerol carboxypeptidase: PRC1 transferase: GTT1 4-(2-aminophenyl) a 1,2-diacyl-sn- a medium-chain lathosterol succinate dADP kinase: YNK1 dGDP kinase: YNK1 C-22 sterol donor:oxygen 3-dehydrosphinganine 3-dehydrosphinganine carrier protein Δ Δ ethanol hydroxyglutarate--pyruvate [+ 2 isozymes] ethyl caproate myo-inositol a relaxed DNA YPR171W CTP synthase: URA8 kinase: URK1 CDP ethanolamine 3- 2-enoyl-CoA dependent) Amine and Polyamine Degradation methyl-L-arginine pyruvate acyl ethyl ester uridine kinase: DAS2 a 3-oxododecanoyl- desaturase: ERG5 oxidoreductase (2,3- reductase: TSC10 reductase: TSC10 assembly (2E, 4E)-undeca- (2E,4Z)-undeca- phosphatidylglycerol -2,4-dioxobutanoate glycerol 3-phosphate Ca 2+ YEL031W Ca 2+ CTP synthase: URA7 uracil bifunctional choline isomerase: ECI1 (3E,5Z)-tetradeca- transhydrogenase: DLD3 [acp domain within epoxidizing): ERG1 a [biotin 2,4-dienoyl-CoA 2,4-dienoyl-CoA phospholipase C: PGC1 an N-terminal L- adjacent thymidine- phosphoribosyltransferase: kinase/ethanolamine γ-L-glutamyl-[(S) 2,4-dinitrophenyl- uracil a fatty acid synthase] (2E,5E)-dodeca- 3,5-dienoyl-CoAΔ Δ a 1,2-diacyl- superpathway CDP kinase: YNK1 ergosta-5,7,22,24(28) (3S)-2,3-epoxy-2,3- carboxyl-carrier 3,5- 2,4- a tRNA Arg arginiyl-3-sulfo- 2’-deoxycytidine sn-glycero-3- FUR1 sphinganine icosasphinganine kinase: CKI1 2,5-dienoyl-CoA -allyl]-L-cysteine gly a carboxylate S-glutathione dGTP dATP dGTP CTP -tetraen-3β-ol dihydrosqualene protein]-L-lysine ethanolamine kinase: EKI1 2,4-dienoyl-CoA 2,4-dienoyl-CoA dienoyl-CoA sn-glycerol of allantoin 4-aminobutyrate L-alanyl-[protein] in DNA phosphocholine YER150W UMP phosphatidate 2-oxoglutarate (R)-lactate Cd 2+ YOR291W Cd 2+ CTP O-phosphoethanolamine reductase: SPS19 reductase: SPS19 isomerase: DCI1 degradation in yeast degradation biosynthesis I (the biotin:apoprotein trans--2-enoyl-CoA (2E,4E)-tetradeca- YPL249C C-24 sterol sphinganine C4- lanosterol synthase: ERG7 dihydroxyacetone ligase: BPL1 hydratase 2: FOX2 2,4-dienoyl-CoA a (3R)-3- reductase: ERG4 hydroxylase: SUR2 (3E)-undec- (3E)-undec- (S)-(+)-allantoin pathway) phosphoethanolamine 4-aminobutanoate a dimer of 3-enoyl-CoA 3-enoyl-CoA Man 9 GlcNAc 2 - hydroxydodecanoyl- a [biotin carboxyl- (3R)-hydroxy- an N-terminal (9Z,15Z)-12,13- Cd 2+ YBR295W Cd 2+ cytidyltransferase: ECT1 gamma- 6 - ergosterol 3-O- a 1-phosphatidyl- DHAP 2,4-dienoyl-CoA [protein] (isomer GDP-α-D-mannose an L-arginyl- adjacent 2’- ν a [histone]-N D-arabinofuranose a double succinate [acp domain within carrier protein]-N putative putative 5-trans- aminobutyrate 3-sulfino-L- h β 1D-myo-inositol a [protein]-L-arginine epoxy-octadeca- ethylphosphate a uracil 20 in tRNA (S)-ureidoglycolate a quinone ergosterol lanosterol phytosphingosine phytoeicosasphingosine dihydroxyacetone 6 reductase: SPS19 glu a (6S)-5- deoxycytidine and acetyl-L-lysine -D-glucoside stranded DNA semialdehyde YER011W a fatty acid synthase] -biotinyl-L-lysine CDP-ethanolamine dodecenoyl-CoA dodecenoyl-CoA allantoinase: DAL1 8A 1,2,3,4 B 1,4 ) alanyl-[protein] [tRNA Arg ] D-arabinose 9,15-dienoatebifunctional dodecenoyl-CoA transaminase: UGA1 formyltetrahydrofolate 3-phosphate phosphate succinate thymidine in DNA succinate YPL056C Δisomerase:Δ DCI1 Δisomerase:Δ DCI1 3-hydroxyacyl-CoA dehydrogenase: arginine N5 aminopeptidase/ tRNA- acyltransferase: 3- 2-enoyl-CoA 3- 2-enoyl-CoA (3E)-tetradec- ethylphosphate ureidoglycolate TOPoisomerase: semialdehyde chloride Carbohydrate Biosynthesis octanoyl-[acyl- dehydrogenase: semialdehyde α histone deacetylase: phosphatidylinositol- ARA1 epoxide NADPH:quinone YJR040W chloride GPT2 ethanolaminephosphotransferase: EPT1 isomerase: ECI1 isomerase: ECI1 initiation-specific -1,6- D-arabinose 1- methyltransferase: phosphatase: PHO8 dihydrouridine 20 carrier protein] dihydroxyacetone 3-enoyl-CoA allantoate succinate hydrolase: DAL3 TOP2 reductase: ZTA1 dehydrogenase: a [biotin carboxyl- FOX2 mannosyltransferase: tetrahydrofolate deoxyribodipyrimidine DEP1 RXT3 RPD3 ergosteryl-β-D- 3-phosphatase: YMR1 RMT2 hydrolase: LAP2 [+ 6 isozymes] synthase: SMM1 arginyltransferase: dehydrogenase epoxide hydrolase: UGA2 biosynthesis phosphate O- (2E)-undec- (2E)-undec- putative semialdehyde SDS3 RXT2 UME1 SIN3 protein N-glycosylation (eukaryotic) initial steps a (2E)-dodec-2-enoyl- carrier-protein (5E)-3-oxo-dodec- OCH1 ATE1 synthase: MET7 photo-lyase: PHR1 glucosidase: EGH1 (NAD(P)(+)): ARA2 (9Z,15Z)-12,13-YNR064C protein N- β dolichyl phosphate (mitochondria, acyltransferase: an L-1- 2-enoyl-CoA 2-enoyl-CoA dodecenoyl-CoA dehydrogenase: putative tetrahydrofolate [protein]-N 5 - a 5,6-dihydrouracil 20 a negatively YEL040W gluconeogenesis 1,3- -D-glucan GDP-mannose [acp domain within 6 CTI6 PHO23 SAP30 a 1-phosphatidyl- D-arabinono- chloride chloride protein O- triacylglycerol a very-long-chain dimer]-N - 5-enoyl-CoA dihydroxyoctadeca- ethanol glyoxylate a semiquinone succinate glycosylation D-mannose biosynthesis yeast) a phytosphingosine a 1-long-chainSCT1 phosphatidylethanolamine isomerase:Δ Δ DCI1 allantoicase: DAL2 UGA2 synthase: RMA1 [+ 5 isozymes] 1D-myo-inositol methyl-L-arginine in tRNA supercoiled DNA YOR390W mannosylation biosynthesis a fatty acid synthase] fatty acyl-CoA biotinyl-L-lysine 3- 2-enoyl-CoA a [protein]-L- 1,4-lactone YBR235W (yeast) biosynthesis biosynthesis acyl-glycerone acetyl-CoA trans--2-enoyl-CoA trans--2-enoyl-CoA 9,15-dienoate I (yeast) an acetoacetyl-[acp] 3-ketoacyl-CoA isomerase: ECI1 succinate asparagine- an N-terminal L- adjacent 2’- a dolichyl phosphate processing 3-phosphate carboxylase hydratase 2: FOX2 hydratase 2: FOX2 (S)-malate β D-glucopyranose D-glucopyranose quinidineK + quinidineK + α a 1,3- -D-glucan 3-oxoacyl-[acyl- biotin carboxylase: thiolase: POT1 (2E)-tetradec- [(mannosyl) 10 (N- a tRNA Arg arginiyl-3-sulfino- deoxycytidine- ergosterol YIL120W UDP-N-acetyl- -D-glucosamine in the ER F6P 6-phosphate ceramide synthase: acylglycerone- subunit: ACC1 GDP a (6S)-5- acetate a [histone]-L-lysine Glc 3 Man 9 GDP-α-D-mannose malate 1,3-β-D-glucan acetyl-coenzyme (S)-ureidoglycolate urea acetylglucosaminyl) ] L-alanyl-[protein] thymidine in DNA ketoconazole ketoconazole glucose-6- sn-glycerol 3-phosphate carrier-protein] LIP1 LAG1 ACC1 (3R)-hydroxy- (3R)-hydroxy- 2-enoyl-CoA 2 formyltetrahydrofolate GlcNAc 2 -[protein] dolichyl-phosphate dehydrogenase: synthase: mannose-6- phosphate A carboxylase (3E)-dec-3- Man GlcNAc phosphate reductase: OAR1 ceramide synthase: undecanoyl-CoA (isomer 8A 1,2,3,4 B 1,2,4 ) YDR534C UDP-N-acetylglucosamine--dolichyl-phosphate Glc 3 9 2 phosphate a dodecanoyl-[acp a (3R)-3- reductase: AYR1 undecanoyl-CoA α mannose MAE1 RHO1 FKS3 glycerol-3-phosphate-O- LAC1 LIP1 subunit: HFA1 enoyl-CoA YOR328W -1,2-glucosidase: [+ 2 isozymes] isomerase: PGI1 hydroxybutanoyl- a [carboxyl-carrier N-acetylglucosaminephosphotransferase: ALG7 synthase: DPM1 cytosolic malate pyruvate isomerase: PMI40 domain within a 1-(long-chain monoacylglycerol metabolism ureidoglycolate CWH41 β β D-mannopyranose F6P acyltransferase: GPT2 protein dimer]-N 6 putative D-galactose YLR081W D-galactose Glc Man a dolichyl -D- dehydrogenase: a 1,3- -D-glucan fatty acid synthase] glycerol-3-phosphate 1- [acp] 2 9 6-phosphate acyl)-sn-glycerol urea-lyase: DAL3 Man 8 GlcNAc 2 - a [protein]-N 6 - (12Z,15Z)-9,10- mannosyl phosphate (3R)-3- a very-long-chain -carboxybiotinyl- dodecenoyl-CoA a uridine 2819 GlcNAc 2 -[protein] MDH2 O-acyltransferase: SCT1 3-phosphate [protein] (isomer GDP-α-D-mannose a [lipoyl-carrier a 1-acyl-sn- a myo-inositol a guanosine 18 a 5’-dephospho- an adenine 37 N-acetyl-α-D-glucosaminyl-diphosphodolichol malate mannose-6- L-lysine isomerase: DCI1 a dietary all-trans-retinyl ester a [DNA]-3’-hydroxyl monoubiquitinyl- RNA (R)-lipoate an adenine in mRNA epoxyoctadeca- glyoxylate 3-methylbutanal hydroxyacyl-[acyl- phytoceramide Δ Δ protein]-L-lysine in 21S rRNA in tRNA [DNA] in tRNA ala Glc Man GlcNAc pyruvate 2-oleoylglycerol 1-oleoyl-sn-glycerol (3R)- (3R)- 3- 2-enoyl-CoA 8A 1,2,3 B 1,3 ) glycerol 3-phosphate 12,15-dienoatebifunctional monophosphate 2 9 2 dehydrogenase: phosphomannomutase: phosphate a 1-acyl-sn- carrier-protein] L-lysine 21S rRNA α carboxylase: PYC1 ceramide very long hydroxynonanoyl- hydroxynonanoyl- isomerase: ECI1 glyoxylate urea inositol-phosphate tRNA-specific YDR077W -1,3-glucosidase: MAE1 SEC53 isomerase: PMI40 glycerol 3-phosphate pseudouridine 2819 mRNA m 6 A aminopeptidase/ polynucleotide D-glucose YMR011W D-glucose YOR275C N-acetylglucosaminyldiphosphodolichol N- pyruvate dehydratase: HTD2 chain fatty acid CoA CoA sphingolipid recycling and degradation (yeast) phosphatase: INM1 tRna ribose glyoxylate 3-methylbutanal adenosine GTB1 ROT2 (2E)-dec-2- α bifunctional triglyceride lipase/ lysophosphatidate synthase: PUS5 methyltransferase: epoxide 5’-hydroxyl- acetylglucosaminyltransferase: ALG13 ALG14 carboxylase: PYC2 α D-mannopyranose lysophosphatidic acid hydroxylase: SCS7 acyl- 1-oleoylglycerol initiation-specific -1,6- RADiation putative rRNA pseudouridine INositol methylase: TRM3 reductase: YPL113C reductase: GRE2 deaminase GlcMan β -D-mannose a (2E)-but- enoyl-CoA a very-long-chain a very-long- urea carboxylase: ubiquitin-specific phosphatase: PHM8 hydrolase: LAP2 9 a dolichyl -D- 6-phosphate a 3-oxotetradecanoyl- acyltransferase: LOA1 palmitoleate mannosyltransferase: lysophosphatidylethanolamine ribonuclease MUM2 IME4 SLZ1 epoxide hydrolase: Monophosphatase: kinase: GRC3 1-phosphate laurate 2-enoyl-[acp] a very-long-chain a 1-acyl-sn- CoA:monoacylglycerol lipase: YJU3 sensitive: DDC1 protease: UBP14 lipoate--protein synthase: NOP10 subunit: TAD1 N-acetyl-β-D-glucosaminyl-(1->4)-N- GlcNAc 2 -[protein] mannosyl phosphate [acp domain within lysophosphatidic acid 2-oleoylglycerol 1-oleoylglycerol mannosylinositol chain mannosyl- DUR1,2 acyltransferase: TGL3 T2: RNY1 biosynthesis acyltransferase: DGA1 a very-long-chain OCH1 [+ 14 isozymes] CBF5 GAR1 NHP2 an N 6 - (12Z,15Z)-9,10-YNR064C INM2 a 2’-O- a drug YOR153W a drug chitin biosynthesis translation (2’R)-2’-hydroxy- glycerol 3-phosphate phospho-(2’R)-2’- MEC3 RAD17 ligase: AIM22 a hypoxanthine 37 acetyl-α-D-glucosaminyl-diphosphodolichol Glc Man GlcNAc dolichyl-phosphate- oxaloacetate a fatty acid synthase] acyltransferase: ICT1 lipase: YJU3 lipase: MGL2 diphosphoinositol-(2’R)- TriacylGlycerol Lipase: TGL5 a 21S rRNA 1 9 2 phosphomannomutase: 1-acyl-sn-gylcerol- enoyl-[acyl-carrier- phytocermide inositol phospho-(2’R)- [+ 3 isozymes] a 1-acyl-sn-glycerol methyladenine dihydroxyoctadeca- myo-inositol methylguanosine 18 glycolate 3-methylbutanol a 5’-phospho-[DNA] α mannose--protein initiation factor lysophosphatidic 1-oleoyl-sn- 3-hydroxy- 3-hydroxy- hydroxyphytoceramide 2’-hydroxyphytoceramide pseudouridine 2819 in tRNA ala YDR032C -1,3-glucosidase: SEC53 3-phosphate acyl protein] reductase, inositol 2’-hydroxyphytoceramide urea-1-carboxylate GlcNAc - in mRNA 12,15-dienoate in tRNA YOR107W chitobiosyldiphosphodolichol catalytic subunit palmitoyl-CoA acid acyltransferase: 1,2-dioleoylglycerol glycerol 3-phosphate mannosyl-inositol- mannosyl- Man 9 2 GTB1 ROT2 mannosyltransferase: mitochondrial: ETR1 heptanoyl-CoA heptanoyl-CoA a 5’-hydroxy- a [lipoyl-carrier β phosphoenolpyruvate α,α-trehalose transferase: SLC1 phosphorylceramide α phospho-α [protein] (isomer a 2’- an [RNA]-3’- -mannosyltransferase: ALG1 Man 9 GlcNAc 2 - PMT2 PMT1 epsilon: GCD6 α-D-mannose LOA1 inositol-phospho- diphosphoinositol- bifunctional urea a [ubiquitin] C- a drug YDR406W a drug carboxylkinase: PCK1 palmitoyl-CoA 9- synthase: KEI1 AUR1 lysophosphatidic 8A B ) a [DNA]-3’-hydroxyl deoxyribonucleoside a [protein]-L-lysine ribonucleoside- ribonucleotide- protein]-N 6 -[(R) [protein] (isomer [+ 4 isozymes] GDP-α-D-mannose 1-phosphate a 1,2-diacyl-sn- hydroxyphytoceramide hydroxyphytoceramide ceramide carboxylase/ GDP 1,2,3,4 1,4 all-trans-retinol a fatty acid terminal glycine β β a 3-O-(α-D- a (3R)-3- desaturase: OLE1 acid acyltransferase: glycerol 3’-[RNA] -lipoyl]-L-lysine -D-Man-(1->4)- -D-GlcNAc-(1->4) 9A a butanoyl-[acp] a very-long-chain phospholipase: ISC1 5’-monophosphate 3’-phosphate 1,2,3 B 1,2,3 ) trehalase: NTH1 glycerol 3-phosphate phospholipase: ISC1 phospholipase: ISC1 allophanate -α-D-GlcNAc-diphosphodolichol mannosyl)-(Ser/ phosphoenol hydroxytetradecanoyl- inositol phospho-(2’R)- ICT1 sterol:steryl ester interconversion alpha,alpha- dolichyl-phosphate palmitoleoyl-CoA 1-acyl-sn-gylcerol- hydrolase: DUR1,2 Thr)-[protein]α pyruvate PSA1: PSA1 [acp domain within phosphatidate 2’-hydroxyphytoceramide a very-long-chain YDR011W YDL049C YOR086C MNS1: MNS1 -D-mannosyl- trehalase: NTH2 mannose inositol 3-phosphate acyl 3-hydroxypentanoyl- 3-hydroxypentanoyl- a drug a drug GDP-Man:Man 1 GlcNAc 2 -PP-dolichol α a fatty acid synthase] phosphatase: APP1 (2’R)-2’-hydroxy- carbamate α [protein] -1,2 phophopyruvate synthase: DPM1 phosphatidate phosphorylceramide transferase: SLC1 CoA CoA a 5’-(N 7 -methyl 5’- -1,3-mannosyltransferase: ALG2 Man 8 GlcNAc 2 - lanosteryl oleate ergosteryl oleate a dimer of adjacent (9Z,12Z)-15,16- acyl-CoA phytocermide a [lipoyl-carrier N-(1-phenylpropan- a uridine 38/ 3-chlorobenzyl mannosyltransferase: hydratase: ERR3 a dolichyl β-D- α diacylglycerol phosphatase: DPP1 mannosyltransferase: a 1,2-diacyl-sn- triphosphoguanosine)- all-trans-octaprenyl ν a ribonucleoside 1-oleoyl-sn- (2R,3S)-3- (2E,4Z)-deca- [protein] (isomer β-D-glucopyranose α-D-glucopyranose GDP- -D-mannose thioesterase: TES1 dihydroceramidase: coenzyme A an apo [peptidyl- pyrimidine h a single octanoate epoxyoctadeca- avenastenone a bleomycin propionamide α β β KTR1 [+ 4 isozymes] kinase (CTP): DGK1 phosphatidate (purine-ribonucleotide) 4-hydroxybenzoate protein]-L-lysine glycerol 3-phosphate 2-yl)hydroxylamine isopropylmalate 39 in tRNA alcohol 2,4-dienoyl-CoA -D-Man-(1->3)- -D-Man-(1->4)- -D- 8A B ) α-D-mannosyl- mannosyl phosphate CSH1 CSG2 glycerol 3-phosphate YDC1 carrier protein] diphosphate nucleosides in DNA triphosphate stranded DNA 9,12-dienoatebifunctional YBR008C 1,2,3 1,3 phosphatase: LPP1 inositol steryl ester hydrolase: TGL1 steryl ester hydrolase: TGL1 a drug a drug GlcNAc-(1->4)-α-D-GlcNAc-diphosphodolichol [protein] α-1,2 a 3-oxohexanoyl- phytoceramidase: -[mRNA] (2R,3S)-3- aminopeptidase/ aryl-alcohol 2-phospho- a (2E)-tetradec-2-enoyl- phosphatidate phosphorylceramide lanosterol O- steryl ester hydrolase: YEH1 ergosterol O- steryl ester hydrolase: YEH1 1-oleoyl-sn-glycerol N,N-dimethylaniline tRNA Leucine putative YOR030W mannosyltransferase: [acp] palmitoleate steryl ester hydrolase: YEH2 steryl ester hydrolase: YEH2 YPC1 isopropylmalate 4- epoxide dehydrogenase: 2,4-dienoyl-CoA 3-keto-steroid YCR089W D-glycerate [acp domain within phosphatase: PAH1 mannosyltransferase: fatty acid biosynthesis oleoyltransferase: ARE2 oleoyltransferase: ARE2 decapping 3-phosphate monooxygenase: pseudouridine 38/39 AminoPeptidases: amidase: AMD2 GDP-Man:Man 2 GlcNAc 2 -PP-dolichol KTR3 α bifunctional triglyceride lipase/ bifunctional triglyceride lipase/ 10-trans- putative methyltransferase: hydrolase: LAP2 AAD10 reductase: SPS19 reductase: ERG27 α α-D-mannosyl- -D-glucopyranose a fatty acid synthase] a very-long-chainCSG2 SUR1 initiation (mitochondria) slanoterol O- ergosterol O- fatty acid oxidation (non-cyclic) a phytosphingosine CO 2 enzyme complex 4-hydroxybenzoate deoxyribodipyrimidine phosphatase: PHM8 FMO1 synthase: DEG1 LAP3 amidase: NTA1 D-glucose D-glucose -1,6-mannosyltransferase: ALG2 lysophosphatidylethanolamine lysophosphatidylethanolamine heptadecenoyl- Phosphopantetheine:Protein DNA primase: lipoate--protein (E)-N-(1- TMT1 epoxide hydrolase: [+ 4 isozymes] α 1-phosphate a 1,2-diacyl-sn-glycerol mannosylinositol oleoyltransferase: ARE1 oleoyltransferase: ARE1 octaprenyltransferase: photo-lyase: PHR1 (2S,3R)-3-hydroxy- D-galactose D-galactose [protein] -1,2 acyltransferase: TGL3 acyltransferase: TGL3 CoA degradation Transferase: PPT2 catalytic subunit: (9Z,12Z)-15,16-YNR064C YOL156W α-D-Man-(1->3)-[α-D-Man-(1->6)]- α glucose-6- PRI2 PRI1 ligase: AIM22 phenylpropan- 2-isopropyl- a pseudouridine 38/ (2E)-dec-2- a deamido- GDP- -D-mannose mannosyltransferase: D-glucopyranose phospho-(2’R)-2’- [+ 2 isozymes] [+ 2 isozymes] DCP1 DCP2 COQ2 3-chlorobenzaldehyde avenasterol propanoate D-fructose D-fructose α β (MFE-dependent) a 2,3,4-saturated 1-oleoyl-sn-glycerol 2-ylidene) dihydroxyoctadeca- -D-Man-(1->4)- -D-GlcNAc-(1->4) phosphate phospholipid: lyso- hydroxyphytoceramide acetyl-CoA coenzyme A a dihydroceramide 4-methoxy-4- 39 in tRNA enoyl-CoA bleomycin D-mannose D-mannose α an α-D-Man-(1->2)KRE2 phosphoglucomutase: (2E, 4E)-undeca- fatty acid 9,12-dienoate - -D-GlcNAc-diphosphodolichol 3-phospho- biosynthesis phosphatidylcholine a (3R)-3- mannosyl-inositol- lanosterol ergosterol hydroxylamine oxobutanoate YOL109W -α-D-Man-3-O- PGM1 acyl-CoA:diacylglycerol acetyl-CoA 2,4-dienoyl-CoA two adjacent a [lipoyl-carrier YCR045C DP-Man:Man 3 GlcNAc 2 -PP-dolichol dolichyl-phosphate mannose synthase: DPM1 acyltransferase: TAZ1 hydroxyhexanoyl- phosphoceramide D-glycerate glucokinase: GLK1 phosphoglucomutase: a myristoyl-[acp acyltransferase: DGA1 a 5’-phosphopurine- N 7 3-octaprenyl-4- pyrimidine protein] N 6 D-glucose D-glucose α-1,2-mannosyltransferase: ALG11 (Ser/Thr)-[protein] D-glucopyranose Lecithin cholesterol acyl-CoA carboxylase: ACC1 trans--2-enoyl-CoA an acyl-CoA dihydroceramidase: 3’,5’-ADP a holo [peptidyl- -methylguanosine ssDNA/pppN(pN) - YHR094C α-D-mannosyl-(1,2) [+ 2 isozymes] PGM2 domain within a [acp] inositolphosphotransferase: IPT1 acetyl-coenzyme 2,3,4-saturated [mRNA] D-mannose D-mannose [+ 5 isozymes] acyl transferase: LRO1 hydrolysis a very-long- phytosphingosine YDC1 carrier protein] 5’-diphosphate hydroxybenzoate nucleosides in DNA n -1 hybrid octanoyl-L-lysine α 3-phosphoglycerate (3R)-3- hydratase 2: FOX2 fatty acyl-CoA α-D-Man-(1->2)-α-D-Man-(1->2)-α-D-Man- - -D-mannosyl- glucokinase: GLK1 fatty acid synthase] chain mannosyl- A carboxylase, (3R)-hydroxy, a dolichyl β-D-mannosyl phosphate α kinase: PGK1 hydroxyacyl-[acyl- ligase: FAA2 (1->3)-[α-D-Man-(1->6)]-β-D-Man-(1->4)-β-D- [protein] -1,2 D-glucopyranose glycogen [+ 2 isozymes] a triacyl-sn-glycerol a 2,3,4-saturated diphosphoinositol-(2’R)- mitochondrial: HFA1 4-trans- phytosphingosine carrier-protein] [+ 3 isozymes] sphinganine α mannosyltransferase: D-glucopyranose 2’-hydroxyphytoceramide undecenoyl-CoA a (3Z)-alk- phytosphingoid Ca 2+ Ca 2+ YOL081W GlcNAc-(1->4)- -D-GlcNAc-diphosphodolichol 6-phosphate biosynthesis dehydratase: HTD2 fatty acyl CoA kinase: LCB5 a dimer of non- an α-D-Man-(1->2) acyl-CoA malonyl-CoA 1-phosphate phytosphingosine YGL167C YBR200W-A KRE2 6-phosphate 3-hydroxyacyl-CoA 3-enoyl-CoA adjacent 2’- 3-methylbutyl an N-terminal 3-hydroxybenzyl a [protein]-L- Mn 2+ Mn 2+ 13-DPG glucose-6- fatty acid thioesterase: ATF1 acetyl-CoA ν -α-D-Man-(1->2) a (2E)-hex- malonyl CoA-acyl phsophatase: LCB3 kinase: LCB4 sphinganine methanethiol O-acetyl-L- h a [DNA]-3’-hydroxyl a 5’-phospho-[DNA] N 1 -acetylspermidine DMAPP an adenosine 37 a uridine in tRNA amphetamine vernolate (2E,6E)-farnesol fumarate butan-1-ol pyrazinamide α acyl-CoA dehydrogenase: a 2,3,4-saturated phytosphingosine deoxycytidine and acetate asparaginyl-[protein] alcohol methionine -α-D-Man-3-O- phosphate UDP- -D-glucose a 3-oxohexadecanoyl- activation 2-enoyl-[acp] sphinganine sphinganine kinase: LCB5 homoserine in tRNA bifunctional thioesterase: TES1 carrier protein FOX2 putative thymidine in DNA tRNA dihydrouridine α α α glyceraldehyde- isomerase: PGI1 glycogenin a 2,3,4-saturated fatty acyl CoA 1-phosphate kinase: LCB3 1-phosphate sphinganine protein N-terminal aryl-alcohol NADPH- fumarate reductase NADPH- -D-Man-(1->2)- -D-Man-(1->2)- -D-Man- (Ser/Thr)-[protein]α-D-Man-(1->2)-α- [acp domain within synthase: DUS1 aminopeptidase/ peptide-methionine putative fatty acid β glucosyltransferase: transacylase, dodecenoyl-CoA phosphatase: YSR3 sphinganine kinase: LCB4 N,N-dimethylaniline a long- (1->3)-[α-D-Man-(1->6)]-β-D-Man-(1->4)-β-D- a dolichyl -D-mannosyl phosphate α 3-phosphate a fatty acid synthase] a long-chain enoyl-[acyl- fatty acid 4-trans-3-oxo- phosphatase: YSR3 tRNA dihydrouridine asparagine epoxide dehydrogenase: dependent alcohol (NADH): FRD1 dependent alcohol Mn 2+ YOL122C Mn 2+ a long-chain vectorial D-Man-(1->2)- -D- 3-phosphoinositide biosynthesis mitochondrial: isomerase: DCI1 kinase: YSR3 sphinganine sphinganine DNA Ligase: monooxygenase: (S)-S-oxide fumarate reductase amidase: AMD2 α dehydrogenase: F6P GLG2 fatty acid undecenoyl-CoA bifunctional cysteine synthase/ PHotoreactivation synthase: DUS4 amidohydrolase: AAD15 dehydrogenase: dehydrogenase: chain fatty GlcNAc-(1->4)- -D-GlcNAc-diphosphodolichol Man-[protein] α-1,3- glycogenin carrier-protein] MCT1 fatty-acyl coenzyme d3,d2-Enoyl-CoA 1-phosphate kinase: LCB3 N1-acetylspermidine transfer RNA isoamyl acetate FMO1 hydrolase: LAP2 reductase: MXR1 amidase: NTA1 fatty acid acylase TDH1 chitosan acyl-CoA O-acetylhomoserine DNL4 LIF1 tRNA dihydrouridine NTA1 epoxide hydrolase: [+ 4 isozymes] ADH6 (NADH): OSM1 ADH6 YBL008W-A acyl-CoA mannosyltransferase: reductase: ETR1 A oxidase: POX1 Isomerase: ECI1 phytosphingosine sphinganine Repair Cell Division complex 2 [+ 2 isozymes] putative glutamine- glucosyltransferase: biosynthesis synthase: FAA3 phosphatase: LCB3 aminocarboxypropyltransferase: oxidase: FMS1 isopentenyl esterase: IAH1 synthase: DUS3 (9Z)-12,13-YNR064C a protein-L- dolichyl-P-Man:Man 5 GlcNAc 2 -PP- 3-ketoacyl-CoA deficient: PHR1 N-(1-phenylpropan- an N-terminal L- pyrazine-2- αMNN1-D-Man-(1->2)-α- -fructose-6- GLG1 [+ 2 isozymes] an acetyl-[acp] a malonyl-[acp] (C18) 1-phosphate kinase: YSR3 Cycle: CDC9 transferase: MOD5 a 5,6-dihydrouridine fatty acid dolichol α-1,3-mannosyltransferase: ALG3 D-glyceraldehyde myo-inositol MET17 dihydroxyoctadeca- 3-hydroxybenzaldehyde (2E,6E)-farnesal methionine- succinate 1-butanal Mn 2+ YHR050W Mn 2+ a long- DHAP α a long-chain thiolase: POT1 in tRNA 2-yl)hydroxylamine aspartyl-[protein] carboxylate vectorial D-Man-(1->2)-α-D- phosphate an -D-glucosyl- a (3R)-3- a hexanoyl-[acp] (S)-S-oxide a long-chain α-D-Man-(1->2)-α-D-Man-(1->2)-α-D- 3-phosphate chitin a (2E)-2-enoyl-CoA phytosphingosine sphinganine 9-enoate chain fatty α transaminase: [glycogenin] hydroxyhexadecanoyl- fatty acyl-CoA fatty acid acylase Man-[protein] -1,3- chitin deacetylase: fatty acid beta- 1-phosphate acyl-CoA Man-(1->3)-[α-D-Man-(1->3)-α-D-Man- phosphatidylinositol 2-trans- 1-phosphate a 2’-deoxycytidine mannosyltransferase: YMR084W [acp domain within acetoacetyl-[acp] putrescine 6 37 complex 1 β β glucoseamine- glycogenin CDA1 nonenoyl-CoA oxidation V acetate met a thymidine in DNA [DNA] 3-acetamidopropanal N -dimethylallyladenosine acetate 3-methylbutanol (1->6)]- -D-Man-(1->4)- -D-GlcNAc- α synthase: PIS1 phospholipid remodeling trans-2-enoyl-CoA aldolase: DPL1 in DNA YOR079C YBR301W peroxisomal an -D-Man-(1->3)MNT3 aldolase: FBA1 6-phosphate chitin deacetylase: a fatty acid synthase] synthase: CEM1 in tRNA Mn 2+ Mn 2+ (1->4)-α-D-GlcNAc-diphosphodolichol α glucosyltransferase: (unsaturated, dihydrosphingosine a long- ABC a long- - -D-Man-(1->2) CDA2 (phosphatidylethanolamine) hydratase 2: FOX2 (R)-2- (mannosyl) 6 -(N-acetylglucosaminyl) 2 - synthase: GFA1 GLG2 a 1-phosphatidyl- trans--2-enoyl-CoA odd number, phosphate lyase: DPL1 transporter -α-D-Man-(1->2) glycogenin chitosan hydroxyhexadecanal chain fatty chain fatty diphosphodolichol:dolichyl β-D-mannosyl di-isomerase- α β-D-fructose D-glucosamine 1D-myo-inositol hydratase 2: FOX2 a 2,3,4-saturated acyl-CoA complex acyl-CoA - -D-Man-3-O- glucosyltransferase: 2-hydroxyhexadecanal a [protein]-N 4 - α α phosphateα mannosyl transferase: ALG9 α-D-Man-(1->3)- 6-phosphate an acetoacetyl-[acp] 1-18:1-2-18:1-phosphatidylethanolamine a (5Z)-alkan-dependent) (3R)-3- 1D-myo-inositol α YGR191W -D-Man-(1->2)- -D-Man-(1->2)- -D-Man- (Ser/Thr)-[protein] 1,6-bisphosphate GLG1 a 3-oxooctanoyl-[acp] (3R)- a dimer of β α α 4 -carboxy- a protein-L- Mn 2+ Mn 2+ PXA1-PXA2 α α a (2E)-hexadec-2-enoyl- dehydrogenase: HFD1 palmitaldehyde UDP-α-D-glucose (N-acetyl-β-D- -D-fructofuranose a [protein]-L- 4 -methyl-5 - 3-diphosphate (2R,3S)-3- (1->3)-[α-D-Man-(1->2)-α-D-Man-(1->3) -D-Man-(1->2)- - glucosamine- α 5-enoyl-CoA hydroxyacyl-CoA coenzyme A an apo-[aryl- a sterol H + hydrogencarbonate non-adjacent hν a guanine 9 in tRNA 4β-methyl-5α- cycloeucalenone methionine- an aldehyde MeOH (1,4- -D-glucosyl) n phosphatidylinositol lysophosphatidylcholine acyltransferase: TAZ1 hydroxynonanoyl- aldehyde 1-phosphate α fructose-1,6- [acp domain within phosphatidylinositol 3-hydroxyacyl-CoA glucosaminyl) tyrosine phosphate cholesta-8-en-3-ol 1,2,4,5,6- isopropylmalate YBR162C -α-D-Man-(1->6)]-β-D-Man-(1->4)-β-D- D-Man-(1->2)- -D- 6-phosphate N- 3-kinase: VPS30 acyl-CoA:lyso-phosphatidylethanolamine fatty-acyl coenzyme aldehyde carrier protein] thymidines in DNA cholesta-8-en-3sterol-4-alpha-β-ol (R)-S-oxide -glucosyl glucogenin 4-kinase: STT4 CoA dehydrogenase -L-asparagine diadenosine and YNL320W α Man-[protein] α-1,3- bisphosphatase: acetyltransferase: a fatty acid synthase] acyltransferase: ALE1 phospholipase A2: TGL4 A oxidase: POX1 dehydrogenase: dehydrogenase: pentakisphosphate NADPH- GlcNAc-(1->4)- -D-GlcNAc-diphosphodolichol [+ 2 isozymes] VPS34 ATG14 (NAD(+)): ALD2 tRNA (guanine 9 -N1) diphosphoinositol carboxylate 3- peptide-methionine UDP-α-D-glucose FBP1 oleoyl-CoA:lysophosphatidylethanolamine aldehyde protein-tyrosine- 3-keto-steroid 3-keto-steroid isopropylmalate dependent alcohol Cu 2+ YIL121W Cu 2+ GlcNAc -PP-dolichol mannosyltransferase: GNA1 VPS15 ATG38 a (2E,5Z)-alka- FOX2 ALD4 -methyltransferase: catalase: CTT1 dolichyl-P-Man:Man 7 2 N-acetyl-D- aldehyde phosphatase: PHO8 polyphosphate dehydrogenase (R)-S-oxide α MNT2α-D-Man-(1->3)- phosphatidylinositol acyltransferase: TGL3 2,5-dienoyl-CoA dehydrogenase Udp- carbonate reductase: ERG27 reductase: ERG27 isomerase: LEU1 dehydrogenase: catalase: CTA1 -1,6-mannosyltransferase: ALG12 glucosamine a 1-phosphatidyl- a 2,3,4-saturated dehydrogenase deoxyribodipyrimidine peptide:N- [+ 10 isozymes] TRM10 phosphohydrolase: (decarboxylating) reductase: MXR2 α α α α-D-Man-(1->2)-α- F6P a (3R)-3- 3-kinase: VPS34 1-(oleoyl)-sn-glycero-3-phosphoethanolamine (NAD(+)): ALD3 Phosphopantetheine:Protein glycosyltransferase: dehydratase: aldolase: FBA1 ADH6 -D-Man-a-(1->2)- -D-Man-(1->2)- - UDP-glucose:dolichyl-phosphate 6-phosphate 1D-myo-inositol putative 3-oxoacyl-CoA photo-lyase: PHR1 glycanase: PNG1 : ERG26 α α α a glucosylated VPS15 VPS30 VPS38 3-hydroxy- (R)-2- (NAD+): ALD5 Transferase: PPT2 ATG26 NCE103 an N 1 - α α DDP1 α α D-Man-(1->3)-[ -D-Man-(1->2)- -D- glucosyltransferase: ALG5 D-Man-(1->2)- -D- hydroxyoctanoyl- 4-phosphate dodecenoyl-CoA aldehyde 4 -methyl-5 - 4 -methyl-5 - a [protein]-L- (2S)-2- YBR067C glucose-6- N-acetylglucosamine- a palmitoyl-[acp methylguanine 9 Ins(1,2,3,4,5,6)P cycloeucalenol an alcohol formaldehyde Cu 2+ YDR270W Cu 2+ Man-(1->3)-[α-D-Man-(1->6)]-α-D-Man- Man-[protein] α-1,3- glycogenin [acp] lysophospholipase: NTE1 heptanoyl-CoA hydroxyhexadecanoate dehydrogenase a [protein]-L-tyrosine cholesta-8-en-3-one 6 cholesta-8-en-3-one methionine isopropylmalate YNL279W phosphate phosphate domain within a a 1-phosphatidyl- lyso-phosphatidylethanolaminelipase: PLB2 isomerase: DCI1 3-oxoacyl CoA in tRNA (1->6)]-β-D-Man-(1->4)-β-D-GlcNAc- mannosyltransferase: UDP-glucose-starch (3R)-3- phosphatidylinositol d3,d2-Enoyl-CoA (NAD(+)): ALD3 a dolichyl β-D-glucosyl phosphate an α-D-Man-(1->3) mutase: PCM1 fatty acid synthase] 1D-myo-inositol lyso-phosphatidylethanolaminelipase: PLB1 thiolase: POT1 aldehyde α isomerase: PGI1 glucosyltransferase: hydroxyacyl-[acyl- Isomerase: ECI1 β UDP β (1->4)- -D-GlcNAc-diphosphodolichol α MNT3 N-acetyl-α-D- 4-phosphate lysophospholipase: PLB3 a sterol 3- - N-acetyl- - a [protein]- DHAP D-glyceraldehyde (mannosyl) 8 -(N-acetylglucosaminyl) 2 - - -D-Man-(1->3) 3-phosphate dehydrogenase a holo-[aryl- CO 2 H 2 O a thymidine in DNA Fe 2+ 2+ GSY2 carrier-protein] a (3E,5Z)-alka- 3’,5’-ADP D-glucoside YMR319C Fe β α D-glucopyranose glucosamine UDP-glucose-starch palmitoyl kinase: MSS4 phosphatidylinositol a 2,3,4-saturated carrier protein] glucosaminylamine L-aspartate diphosphodolichol:dolichyl -D-mannosyl - -D-Man-(1->2) dehydratase: HTD2 (NAD(+)): ALD2 Cu + Cu + 6-phosphate glucosyltransferase: 3,5-bisphosphate phoshatidylinositol-3- sn-glycero-3-phosphoethanolamine 3,5-dienoyl-CoA phosphate mannosyl transferase: ALG9 -α-D-Man-(1->2) 1-phosphate transacylase: FAS1 a 1-phosphatidyl- fatty acyl CoA YBR056W α-D-Man-(1->2)-α-D-Man-(1->2)-α-D-Man- UDP-N- a (2E)-oct- a 1-phosphatidyl- 3-hydroxypentanoyl- YNL209W -α-D-Man-3-O- GSY1 1D-myo-inositol 5-phosphatase: phosphate 5-kinase: Δ3,5-Δ2,4- pentadecanoate palmitate (1->3)-[α-D-Man-(1->2)-α-D-Man-(1->3) acetylglucosamine 2-enoyl-[acp] 1D-myo-inositol CoA (Ser/Thr)-[protein] a glucosylated 3,4-bisphosphate ATG18 VAC7 ATG18 VAC7 iron(III)-[N-(2,3- 7-(2-hydroxy- 2,5-diamino-6- -[α-D-Man-(1->2)-α-D-Man-(1->6)]-α-D- palmitoyl-CoA glycerophosphodiester dienoyl-CoA 2,3,4-saturated 2,3,4-saturated 1D-myo-inositol β pyrophosphorylase: glycogenin 4,5-bisphosphate FIG4 VAC14 FAB1 FIG4 VAC14 FAB1 a DNA containing an 1-acyl-2- Cu + YLR411W Cu + β β a dolichyl -D-glucosyl phosphate phosphodiesterase: GDE1 isomerase: DCI1 3-aci- dihydroxybenzoyl) 3-amino-3- (5-phospho-D- adenine 2142 1-diphosphate S-(hydroxymethyl) an N-terminal an aromatic Man-(1->6)]- -D-Man-(1->4)- -D-GlcNAc- QRI1 enoyl-[acyl- [+ 2 isozymes] fatty acyl-CoA fatty acyl-CoA ubiquinone-6 a reduced electron- an apurinic/ arachidonoyl- 31-norcycloartanone 2,5-hexanedione (2R)-homocitrate Cu 2+ -L-serine carboxypropyl) ribosylamino) α chitin UDP-N-acetyl- 1,4-glucan-6- carrier-protein] transfer flavoprotein nitropropanoate in 25S rRNA 2,3,4,5,6- glutathione glycyl-[protein] primary alcohol (1->4)- -D-GlcNAc-diphosphodolichol acyl-CoA 1-phosphatidyl- a (2E,4E)- phosphatidylcholine ligase: FAA2 ligase: FAA2 apyrimidinic site sn-glycerol 2,5-diamino-6- α (1,4-glucano)- [+ 3 isozymes] [+ 3 isozymes] trimer] complex -wyosine 37 pyrimidin-4(3H)-one 25S rRNA pentakisphosphatediadenosine and S-hydroxymethyl- trehalose -D-glucosamine reductase: ETR1 1D-myo-inositol ethanolamine dienoyl-CoA resynthesis via 7-(2-hydroxy-3-amino- aryl-alcohol cupric (mannosyl) 9 -(N-acetylglucosaminyl) 2 - thioesterase: TES1 in tRNA Phe (ribosylamino)- diphosphoinositol YBR053C YNL145W biosynthesis I transferase: GLC3 (adenine2142-N1)- 3-keto-steroid glutathione 2,5-hexadione N-myristoyl homoaconitate dehydrogenase: reductase: FRE2 Cu + YPR124W Cu + diphosphodolichol glucosyltransferase: ALG6 chitin synthase: 3,5-bisphosphate glycerophosphocholine pentadecanoyl-CoA palmitoyl-CoA putative 3-carboxypropyl) 4(3H)-pyrimidinone 1-phosphatidyl- putative nitronate bifunctional N- methyltransferase: reductase: ERG27 polyphosphate dehydrogenase: reductase: GRE2 cupric CHS2 UDP-α-D- 2,4-dienoyl-CoA -wyosine transferase: NMT1 hydratase: LYS4 AAD15 α-D-Glc-(1->3)-α-D-Man-(1->2)-α-D-Man- a glycogen an octanoyl-[acp] 1D-myo-inositol Changed glycosylase/AP diacylglycerol ferric-chelate 5’-phosphate phosphohydrolase: [+ 4 isozymes] D-glucopyranose [+ 3 isozymes] palmitate reductase: SPS19 monooxygenase: 2,5-diamino-6- BMT2 SFA1 reductase: FRE1 α α α galactose CDP-choline Intracellular lipase: TGL3 reductase: FRE5 7-[4-methoxy-(2-carboxycarbonylase: reductase: RIB7 (1->2)- -D-Man-(1->3)-[ -D-Man-(1->2)- -D- dolichyl glucosyl UDP-α-D-glucose 3,4,5-trisphosphate YJR149W lyase ogg2: NTG1 DDP1 an N-terminal 6-phosphate biosynthesis diacylglycerol Redox state: CIR2 [+ 4 isozymes] [+ 4 isozymes] PPM2 (5-phospho-D- N 1 -methyladenine 2142 (1R,2S)- an aromatic Man-(1->3)-[α-D-Man-(1->2)-α-D-Man-(1->6) phosphate hydroxy-3-amino- 31-norcycloartanol Ins(1,2,3,4,5,6)P S-formylglutathione (2S,5S)-hexanediol N-myristoyl- Cu + YIR028W β cholinephosphotransferase: ribitylamino) in 25S rRNA 6 homoisocitrate aldehyde allantoin allantoin ]-α-D-Man-(1->6)]-β-D-Man-(1->4)-β-D- biosynthesis chitin oleate - a (3E)-3-enoyl-CoA 3-carboxypropyl) glycyl-[protein] UDP-α-D-glucose CPT1 pyrimidin-4(3H)-one YAL063C YNL093W α alpha,alpha- oxidation ]-wyosine 37 GlcNAc-(1->4)- -D-GlcNAc-diphosphodolichol Secondary Metabolite Biosynthesis diacylglycerol [unspecified N-(2,3- D-glucopyranose trehalose-phosphate (thioesterase- putative an oxidized a 3’-terminal α H + ubiquinol-6 3-oxopropanoate nitrite degradation a 5’-phospho-[DNA] 2-arachidonoylglycerol a fatty acid in tRNA Phe (glucosyl)-(mannosyl) 9 -(N-acetylglucosaminyl) UDP- -D- UDP-glucose 4- cholinephosphotransferase: dihydroxybenzoyl) Fe 2+ 2+ Zn 2+ 6-phosphate dependent) dodecenoyl-CoA electron-transfer unsaturated sugar Zn YOR316C -diphosphodolichol glucosyltransferase: ALG8 phosphoglucomutase: synthase: TPS1 epimerase: GAL10 EPT1 products] 2 glucose PRPP biosynthesis flavoprotein -L-serine trimer Co 2+ Co 2+ α-D-Glc-(1->3)-α-D-Glc-(1->3)-α-D-Man- PGM1 UDP-α-D-galactose inositol phosphate biosynthesis (2E,5Z)- isomerase: DCI1 a phosphatidylcholine phosphoglucomutase: α α biosynthesis I D-myo-inositol (1,4,5)- D-myo-inositol (1,3,4) 1D-myo-inositol all-trans- d3,d2-Enoyl-CoA (1->2)-α-D-Man-(1->2)-α-D-Man-(1->3) , -trehalose phosphatidylinositol tetradecenoyl-CoAputative α PGM2 trisphosphate biosynthesis -trisphosphate hexakisphosphate biosynthesis farnesol Isomerase: ECI1 YNL033W -[α-D-Man-(1->2)-α-D-Man-(1->3)-[α-D- -D-glucopyranose 6-phosphate trehalose D-glucopyranose phosphate biosynthesis dodecenoyl-CoA phosphatidyl a dimer of non- D-ribose 5-phosphate a 1-phosphatidyl- biosynthesis I (from Ins(1,4,5)P3) biosynthesis a 1-acyl-2- Man-(1->2)-α-D-Man-(1->6)]-α-D-Man- 1-phosphate biosynthesis II 6-phosphate phospholipase a factor YKL209C a factor trehalose-6- phosphoglucomutase: phosphoribosylpyrophosphate 1D-myo-inositol isomerase: DCI1 a (2E)-2-enoyl-CoA 7,8-dihydrofolate an [eIF5A- RNase III mRNA adjacent 2’- arachidonoyl- 5-(hydroxymethyl) a [release factor]- 4-nitrophenyl a (2E,4Z)- D-myo-inositol Δ3,Δ2-enoyl-CoA hydrogen peroxide a reduced NADPH H + spermidine hν a 3-oxosteroid a uracil 17 in tRNA coniferyl alcohol zymostenol phytenoyl-CoA ferulate (1->6)]-β-D-Man-(1->4)-β-D-GlcNAc- a CDP- myo-inositol B: NTE1 monoglutamate precursor]-lysine processing substrate deoxycytidines -2-methylphenol L-glutamine dienoyl-CoA UDP-glucose phosphate PGM1 synthetase: PRS5 PRS2 4,5-bisphosphate myo-inositol isomerase: ECI1 thioredoxin phosphatidylinositol phosphate (1->4)-α-D-GlcNAc-diphosphodolichol D-glucopyranose phosphoglucomutase: ribose-phosphate (1,3,4,5)- Ins(1,4,5)P 3 IPP pyrophosphorylase: UGP1 α phosphoinositide- diacylglycerol (3E,5Z)-tetradeca- sn-glycero-3- in DNA 4-phosphate putative aryl-alcohol phosphatase: TPS2 ADP- -D-glucose tetrakisphosphate peptide chain release dolichyl-P-Glc:Glc 2 Man 9 GlcNAc 2 -PP- UTP glucose-1-phosphate 6-phosphate α-D-glucopyranosePGM2 pyrophosphokinase: PRS2 PRS1 specific 3,5-dienoyl-CoA 1-phosphatidylinositol- tRNA- coniferyl alcohol ferulate α ribose-phosphate phosphatidylinositol phosphocholine dehydrogenase: factor N 5 -glutamine 3-keto-steroid p-nitrophenyl 2,4-dienoyl-CoA 3-keto-steroid 2-enoyl thioester a 1,2-diacyl- Ups1-Mdm35 a 1,2-diacyl- dolichol -1,2-glucosyltransferase: DIE2 uridylyltransferase: α,α-trehalose 1-phosphate phospholipase IPP isomerase: IDI1 4-phosphate 5- dihydrouridine 17 acetyltransferase: decarboxylase: YMR251W-A α-D-Glc-(1->2)-α-D-Glc-(1->3)-α-D-Glc- pyrophosphokinase: PRS3 PRS1 phosphatidylinositol synthase: PIS1 inositol 1,4,5- inositol putative thioredoxin AAD15 methyltransferase: reductase: ERG27 phosphatase: PHO13 reductase: SPS19 reductase: ERG27 reductase: ETR1 sn-glycerol phosphatidate sn-glycerol YHL012W ADP-glucose trehalose- C: PLC1 inositol 1,4,5- ARGRIII inositol acyl-CoA β dihydrofolate deoxyhypusine ribonuclease deoxyribodipyrimidine kinase: MSS4 [+ 4 isozymes] synthase: DUS1 ATF1 FDC1 α α α UDP-glucose ribose-phosphate synthase: PIS1 trisphosphate 3- polyphosphate 5- glycerophosphocholine fatty acid -oxidation (peroxisome) peroxidase: SCO2 a 1-acyl-2- MTQ2 TRM112 3-phosphate transporter 3-phosphate (1->3)- -D-Man-(1->2)- -D-Man-(1->2)- - trisphosphate 3- polyphosphate glycerol thioredoxin reductase: DFR1 synthase: DYS1 III: RNT1 photo-lyase: PHR1 a [release factor]- UDP-α-D-glucose 6-phosphate synthase pyrophosphokinase: PRS4 PRS1 kinase: ARG82 DMAPP thioesterase: TES1 phosphodiesterase: GDE1 α D-Man-(1->3)-[α-D-Man-(1->2)-α-D-Man- pyrophosphorylase: UGP1 Ins(1,4,5)P a 1-phosphatidyl- phosphatase: INP53 degradation I arachidonoyl-sn- 3-hydroxy-4- a 5,6-dihydrouracil 17 5 -cholesta- UTP glucose-1-phosphate ribose phosphate 3 kinase: ARG82 multikinase: ARG82 peroxidase: DOT5 N 5 -methyl- a 3β-hydroxysteroid 4-nitrophenol a (3E)-3-enoyl-CoA coniferyl acetate phytanoyl-CoA 4-vinylguaiacol α α a 1-phosphatidyl- [+ 2 isozymes] glycero-3-phospho- methylbenzaldehyde in tRNA 8-en-3-one (1->3)-[ -D-Man-(1->2)- -D-Man-(1->6) diphosphokinase: PRS5 PRS4 1D-myo-inositol (3E,5Z)- UDP-glucose:dolichyl- uridylyltransferase: a (2E)-2-enoyl-CoA L-glutamine ]-α-D-Man-(1->6)]-β-D-Man-(1->4)-β-D- α α PRPP 1D-myo-inositol D-myo-inositol D-myo-inositol choline D-myo-inositol Na + Na + phosphate , -trehalose 6-phosphate YHL012W phosphatidylinositol Ins(1,4,5)P 3 dimethylallyltransferase: tetradecadienoate glycerol an [eIF5A- RNase III YDR040C YMR192W GlcNAc-(1->4)-α-D-GlcNAc-diphosphodolichol inositol 1,4,5- (1,3,4,5)- (1,4,5,6)- 5,6,7,8- a 2’-deoxycytidine 4,5-bisphosphate Li + Li + dolichyl-diphospho-oligosaccharide- D-myo-inositol ERG20 2,3,4-saturated fatty an oxidized NADP + glucosyltransferase: ALG5 α 4-kinase: STT4 glycerol H 2 O propane-1,3-diamine precursor]- an mRNA fragment processing UDP- -D-glucose trisphosphate 3- phosphatidylinositol tetrakisphosphate tetrakisphosphate tetrahydrofolate in DNA protein glycosyltransferase: OST1 OST2 β phosphatidylinositol [+ 2 isozymes] (1,3,4)-trisphosphate a 2,3,4-saturated fatty acidacyl-CoA ligase: FAA2 trans-2-enoyl-CoA thioredoxin deoxyhypusine product mRNA a dolichyl -D- trehalose-6-phosphate kinase: ARG82 kinase: GUT1 [+ 3 isozymes] OST4 OST5 OST6 SWP1 WBP1 STT3 3-kinase: VPS30 4-kinase: STT4 hydratase 2: FOX2 dolichyl-diphospho-oligosaccharide- glucosyl phosphate phosphatase: TPS2 [+ 2 isozymes] a 1-phosphatidyl- a 1-phosphatidyl- inositol-1,3,4,5- inositol-1,4,5,6- geranyl diphosphate D-myo-inositol VPS34 ATG14 sn-glycerol fatty-acyl coenzyme a nucleoside YAL022C a nucleoside protein glycosyltransferase: OST3 OST2 D-myo-inositol 1D-myo-inositol 1D-myo-inositol tetrakisphosphate tetrakisphosphate (1,4,5,6)- VPS15 ATG38 fatty acid β- 3-phosphate A oxidase: POX1 a 2,3,4-saturated (3R a 6-(N-acetyl-α- SWP1 OST1 OST5 STT3 OST4 WBP1 α α phosphatidylinositol 5-phosphate 4-phosphate ω a 2,3,4-saturated fatty acyl CoA a dimer of non- YMR040W , -trehalose (1,3,4,5)- tetrakisphosphate a 1-phosphatidyl- 6-kinase: ARG82 3-kinase: ARG82 ,E,E-farnesyl oxidation III 3-hydroxyacyl-CoA)-3-hydroxyacyl-CoA α α α 3-kinase: VPS34 glycerol-3- D-glucosaminyl) a dimer of adjacent a nucleoside 4,4-dimethyl-5 - 4 -methyl-5 - 4-isopropylbenzyl (2S,3S)-2- tetrakisphosphate 1D-myo-inositol diphosphate malonyl-CoA palmitoyl-CoA H + sulfite GSSH hν hν adjacent pyrimidine uroporphyrinogen-III (S)-nicotine a uracil 54 in tRNA a uracil 16 in tRNA NADP + urea Glc 3 Man 9 GlcNAc 2 -[protein] (unsaturated, dehydrogenase: FOX2 -1-phosphatidyl- thymidines in DNA cholesta-8-en-3β-ol cholest-7-en-3-one alcohol methylcitrate VPS15 VPS30 VPS38 phosphatidylinositol- phosphatidylinositol phosphate nucleosides in DNA triphosphate inositol-1,4,5,6- 4-phosphate synthase: ERG20 odd number) phospholipids degradation 1D-myo-inositol a xenobiotic YLR266C a xenobiotic inositol-1,3,4,5- 5-phosphate 4- 4-phosphate dehydrogenase: aryl-alcohol cyanamide tetrakisphosphate phosphatidylinositol a (3Z)-alk- nucleoside triphosphate uroporphyrinogen-III N,N-dimethylaniline Transfer RNA tRNA- NADP+ a 1-phosphatidyl- kinase: MSS4 kinase: MSS4 GUT2 delta(14)-sterol 3-keto-steroid dehydrogenase: prpD Homolog: tetrakisphosphate D-myo-inositol (2E,6E)-farnesyl pyrophosphohydrolase: C-methyltransferase: monooxygenase: Methyltransferase: dihydrouridine 16 hydratase: DDI2 3-kinase: ARG82 1D-myo-inositol 4-phosphate 3-enoyl-CoA a 1-phosphatidyl- phosphatase: PHO8 cyanamide 6-kinase: ARG82 diphosphate putative DHAP thiosulfate reductase: ERG24 reductase: ERG27 AAD15 PDH1 kinase: MSS4 1,3,4,5,6- a phosphatidylcholine N-acetylglucosaminylphosphatidylinositol 3-oxooctadecanoyl- deoxyribodipyrimidine deoxyribodipyrimidine HAM1 MET1 FMO1 TRM2 synthase: DUS1 [+ 5 isozymes] [+ 4 isozymes] YMR031C 3-phosphate a 1-phosphatidyl- dodecenoyl-CoA 1D-myo-inositol a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated 3-oxoacyl-CoA sulfurtransferase: [+ 2 isozymes] hydratase: DDI3 YLR034C phoshatidylinositol-3- pentakisphosphate CoA synthase: ELO1 photo-lyase: PHR1 photo-lyase: PHR1 Fe 2+ Fe 2+ a 1-phosphatidyl- 1D-myo-inositol inositol diphosphates biosynthesis (2E,6E)-farnesyl isomerase: DCI1 4,5-bisphosphate de-N-acetylase: GPI12 RDL1 4,4-dimethyl- phosphate 5-kinase: inositol (1,3,4,5,6)- d3,d2-Enoyl-CoA a 5-methyluracil 54 a 5,6-dihydrouracil 16 cis-2- 4,5-bisphosphate a nucleoside 5’- precorrin-2 nicotine-1’-N-oxide 5-α-cholesta- lophenol NAD + p-cumic aldehyde cyanamide 1D-myo-inositol diphosphate in tRNA in tRNA methylaconitate ATG18 VAC7 phosphoinositide- pentakisphosphate Isomerase: ECI1 phospholipase phosphoinositide- monophosphate β 4,5-bisphosphate D-myo-inositol phosphatase: PHO8 α 8,14-dien-3- -ol D-myo-inositol FIG4 VAC14 FAB1 specific 2-kinase: IPK1 a (2E)-2-enoyl-CoA D: SPO14 3-oxoacyl CoA thiolase: POT1 6-( -D- phosphatidylinositol specific Fe 2+ YKR052C Fe 2+ 1,3,4,5,6- 1-phosphatidyl- 1,3,4,5,6- [+ 2 isozymes] glucosaminyl)- 3-oxooctadecanoyl- two adjacent a pyrimidine 4,5-bisphosphate 5- phospholipase phospholipase pentakisphosphate (2E,6E)-farnesol acetate glutathione thiosulfate YML006C pentakisphosphate 1D-myo-inositol C: PLC1 1-phosphatidyl- CoA thymidines in DNA nucleoside in DNA phosphatase: INP53 Ins(1,2,3,4,5,6)P 6 a 1,2-diacyl-sn- C: PLC1 3,5-bisphosphate [+ 3 isozymes] homofuraneol 1D-myo-inositol inositol (1,3,4,5,6)- phosphatidylinositol inositol (1,3,4,5,6)- glycerol 3-phosphate pKC1 a 1-phosphatidyl- Ins(1,4,5)P 3 pKC1 biosynthesis Fe 2+ YJL133W Fe 2+ pentakisphosphate 3,5-bisphosphate pentakisphosphate a dimer of Suppressor: KCS1 1D-myo-inositol Suppressor: KCS1 a dimer of adjacent N-methyl-N-[(2S)- 4α-methyl-5α- 2-kinase: IPK1 5-phosphatase: 2-kinase: IPK1 a 1,2-diacyl- non-adjacent a 1-acyl-2-lyso- S-(2-hydroxyacyl) a [histone H3]- 4α-methyl- (2R,3S)-3- D-glyceraldehyde 4-phosphate [+ 2 isozymes] hν malonyl-CoA H + myristoyl-CoA 2’-deoxycytidines hν 1-phenylpropan-2- ergosta-8,14,24(28) 2-hydroxyisobutyramide a uracil 47 in tRNA thiosulfate ethanol [+ 2 isozymes] ATG18 VAC7 sn-glycerol thymidine and phosphatidylethanolamine glutathione a polyphosphate L-lysine-36 cholesta-8,14-dienol isopropylmalate 3-phosphate YLR443W a diphospho-1D- a diphospho-1D- gly in DNA yl]hydroxylamine -trien-3β-ol FIG4 VAC14 FAB1 glutathione-mediated Detoxification 2’-deoxycytidine glyceraldehyde myo-inositol [+ 2 isozymes] myo-inositol myo-inositol D-ribose detoxification II reactive oxygen in DNA endopolyphosphatase: histone H3 lysine-36 N N,N-dimethylaniline putative tRNA- 3-isopropylmalate 3-phosphate thiosulfate tetrakisphosphate a 1-phosphatidyl- biosynthesis tetrakisphosphate delta(14)-sterol delta(14)-sterol catalase: CTT1 YKR014C Ins(1,2,3,4,5,6)P 6 Ins(1,2,3,4,5,6)P 6 species degradation PPN1 -trimethyltransferase: monooxygenase: amidase: AMD2 dihydrouridine 47 dehydrogenase: dehydrogenase: sulfurtransferase: 1D-myo-inositol lysophospholipase: PLB3 hydroxyacylglutathione polyphosphatase: reductase: ERG24 reductase: ERG24 catalase: CTA1 3-oxopalmitoyl- lysophospholipase: PLB1 deoxyribodipyrimidine SET2 FMO1 amidase: NTA1 synthase: DUS3 LEU2 TDH2 RDL1 D-glucopyranose RX deoxyribodipyrimidine hydrolase: GLO2 DDP1 [+ 2 isozymes] 3-phosphate CoA synthase: ELO1 lysophospholipase: PLB2 photo-lyase: PHR1 α photo-lyase: PHR1 glyoxylase-II: GLO4 a [histone H3] N 6 (Z)-methyl(oxido) 4 -methyl- pKC1 6-phosphate pKC1 pKC1 pKC1 superoxide lysophospholipase: NTE1 4α-methyl-5α- 2-hydroxy-2- a 5,6-dihydrouracil 47 4-methyl-2- 3-phospho- YLR373C L-myo-inositol- glutathione ,N 6 ,N 6 -trimethyl- (1-phenylpropan- 5α-ergosta- sulfite acetaldehyde Suppressor: KCS1 Suppressor: KCS1 Suppressor: KCS1 Suppressor: KCS1 an oligophosphate cholesta-8-en-3-ol methylpropanoate in tRNA oxopentanoate D-glycerate 1-phosphate transferase: GTT2 L-lysine-36 2-ylidene)azanium 8,24-dien-3β-ol norfuraneol superoxide 1D-myoinositol synthase: INO1 1D-myo-inositol 1D-myoinositol 1D-myo-inositol glutathione two adjacent 2’- a diphospho-1D- dismutase: SOD1 a 2’-deoxycytidine sn-glycero-3- a 2-hydroxy 5-diphosphate 3-diphosphate 5-diphosphate 1-diphosphate transferase: GTT1 [+ 2 isozymes] a thymidine in DNA 3-oxopalmitoyl-CoA a carboxylate deoxycytidines glutathione YKL065C myo-inositol Ins(3)P Aldehyde Degradation [+ 2 isozymes] in DNA phosphoethanolamine carboxylate 1,2,3,4,6- 1,2,4,5,6- 1,2,3,4,6- 2,3,4,5,6- in DNA pentakisphosphate YLR310C pentakisphosphate inositol pentakisphosphate pentakisphosphate pentakisphosphate a glutathione- hydrogen peroxide methylglyoxal S-conjugate monophosphate: 3-diphosphoinositol diphosphoinositol diphosphoinositol- (2E)-2-ethylidene-4- methylglyoxal methylglyoxal β a very-long-chain a [protein] C- INM2 degradation V D-threo-7,8- a -D- 3,5-bisdiphosphoinositol- α 38- pentakisphosphate diphosphoinositol pentakisphosphate diphosphoinositol diphosphoinositol pentakisphosphate hydroxy-5-methyl- catabolism 3-methyl-2- 5,10-methylene- 5-amino-4- an α-D-mannoside a [histone H3]- 4 -methyl ergosta- a uridine a [protein]- phosphoenol 1D-myo-inositol degradation VII glutathione glutathione glutathione PRPP fructofuranoside 1D-myo-inositol 2,3,4,6- methamphetamine a uracil 20b in tRNA 2,3,4-saturated terminal S- Fe 2+ kinase: VIP1 5-kinase: VIP1 pentakisphosphate pentakisphosphate 5-kinase: KCS1 catalase: CTT1 oxobutanoate tetrahydromethanopterin imidazolecarboxyamide dihydroneopterin L-lysine-79 8,14,25(27)-trienol 40 in tRNA L-cysteine pyruvate pentakisphosphate 3-monophosphate 3(2H)-furanone S-conjugate catalase A: CTA1 fatty acyl CoA farnesyl-L-cysteine 5-kinase: KCS1 5-kinase: KCS1 (2E)-2-ethylidene-4- S-conjugate peroxidase: GTT1 tetrakisphosphatediadenosine and bifunctional DRAP 5-kinase: KCS1 phosphatase: INM1 methylglyoxal carboxypeptidase: [+ 3 isozymes] pyruvate YJL171C hydroxy-5-methyl- methylglyoxal transport: YCF1 diphosphoinositol histone H3 lysine-79 N N,N-dimethylaniline tRNA- very-long-chain protein S- YLR219W Ins(1,2,3,4,5,6)P 6 methylglyoxal methylglyoxal glutathione delta(14)-sterol deaminase/tRNA ferroxidase: FET3 kinase: PYK2 3(2H)-furanone aldehyde PRC1 -trimethyltransferase: monooxygenase: dihydrouridine 20b enoyl-CoA acyltransferase: STErile: STE14 myo-inositol reductase: GRE3 glutathione S-conjugate 3-methyl-2-oxobutanoate adenine alpha mannosidase: polyphosphate reductase: ERG24 pseudouridine ferroxidase: FET5 pyruvate 1D-myo-inositol 1,5- NADPH-dependent O 2 hydroxyl radical FOLic acid invertase: SUC2 DOT1 FMO1 synthase: DUS4 reductase: TSC13 SHR5 ERF2 a bis(diphospho) 3,5-bisdiphosphoinositol- reductase: YNL134C glyoxalase I: GLO1 dehydrogenase: S-conjugate hydroxymethyltransferase: phosphoribosyltransferase: phosphohydrolase: synthase: RIB2 kinase: CDC19 transport: YBT1 H 2 O AMS1 a [protein] C- bis(diphosphate) methylglyoxal ALD4 ABC-type synthesis: FOL1 1D-myo-inositol 6 -1D-myo-inositol 1D-myo-inositol 2,3,4,6- carboxypeptidase: ECM31 APT2 DDP1 a [histone H3] N N-methyl-N-[(2S)- α a very-long- terminal S- 2,3,4,6- homofuraneol reductase: GRE2 (R)-S- aldehyde glutathione- a 5,6-dihydrouracil 20b 4 -methyl ergosta- a pseudouridine 38- a [protein]-S- ATG42 3-diphosphate ,N 6 ,N 6 -trimethyl- 1-phenylpropan-2- chain trans-2,3- Fe 3+ pyruvate tetrakisphosphate tetrakisphosphate (S)-lactaldehyde dehydrogenase in tRNA 40 in tRNA farnesyl-L-cysteine tetrakisphosphate lactoylglutathione S-conjugate 1,2,4,5,6- 8,25(27)-dienol palmitoyl-L-cysteine L-lysine-79 yl]hydroxylamine dehydroacyl-CoA methyl ester YLR046C (NAD+): ALD5 a [γ-glutamyl- transporter: BPT1 aldehyde aldehyde:NAD+ α a non glycosylated β a glycoside pentakisphosphate YIR019C glyoxylase-II: GLO4 -D-mannopyranose 6-(hydroxymethyl) glycolaldehyde -D-fructofuranose glyoxalase II oxidoreductase: L-cysteine]- 2-dehydropantoate THMPT AICAR sugar acceptor dehydrogenase: 8-oxo-(d)GTP -7,8-dihydropterin (cytoplasmic): GLO2 ALD3 S-conjugate a glutathione- arsenate detoxification L-histidine biosynthesis Amino Acid Biosynthesis ALD4 aldehyde:NAD+ detoxification I superpathway of phenylalanine, tyrosine and tryptophan biosynthesis diphthamide L-methionine biosynthesis III aldehyde S-conjugate sulfate YPR003C sulfate superpathway of branched L-lysine superpathway of sulfur L-asparagine oxidoreductase: biosynthesis dehydrogenase (R)-lactate glutathione chain amino acid biosynthesis biosynthesis IV amino acid biosynthesis biosynthesis I ALD2 Man 8 GlcNAc 2 - a 1-acyl-2- (NAD+): ALD5 S-conjugate arsenate (Saccharomyces cerevisiae) 5-enolpyruvoyl- 3-deoxy-D-arabino- aldehyde:NAD+ pyruvate [protein] (isomer a glycogen a cytosine 2870 an organic (indol-3-yl) YLR092W PRPP 3-(4-hydroxyphenyl) phosphoenol an L-histidine- D-lactate γ acetyl-CoA malonyl-CoA NADPH H + glutathione dehydroascorbate N 1 -acetylspermine arachidonoyl- an organic molecule a guanine 46 in tRNA a uracil 20a in tRNA formaldehyde citrate ferroheme o trans-dienelactone sulfate sulfate prephenate shikimate 3-dehydroquinate 3-dehydroshikimate shikimate -glutamate dGTP GTP in 25S rRNA hydroperoxide acetamide ATP methionine shikimate heptulosonate [translation oxidoreductase: 8A 1,2,3 B 1,3 ) 2-oxoglutarate pyruvate pyruvate 3-phosphate L-homoserine dehydrogenase hydrolase: ECM38 phosphatidylinositol YHR214W pyruvate sulfate 3-phosphate 7-phosphate 2-(3-amino-3- asp ALD3 an (L- 25S rRNA thr salvage pathway L-tyrosine:2- elongation factor 2] aldehyde:NAD+ cytoplasmic 1-phosphatidylinositol Transfer RNA tRNA- dienelactone YBR294W homocitrate prephenate 3-deoxy-D-arabine- shikimate carboxypropyl) asparagine (cytochrome):D-lactate DLD3 alkyl hydroperoxide aconitate sulfate sulfate cysteinylglycine) (mannosyl) 8 (N- putative cytochrome (cytosine 2870 -C 5 )- formaldehyde amidase: NTA1 heme a synthase: LYS21 oxoglutarate heptulosonate- 3-phosphoshikimate 1- 3-dehydroquinate shikimate synthase (glutamine- oxidoreductase: arsenate 4-kinase: PIK1 methyltransferase: dihydrouridine 20a reductase: AHP1 hydratase: ACO2 hydrolase: homocitrate sulfate chorismate dehydrogenase: 3-dehydroquinate dehydrogenase: a 2-[(3S)-3-amino-histidine synthase: homoserine O- ferricytochrome -S-conjugate fatty-acyl-CoA glutathione acetylglucosaminyl) glucan 1,4-alpha- P450: DIT2 methyltransferase: reductase: YLL056C amidase: AMD2 synthase: COX15 acetolactate L-threonine S-methyl-5’- aminotransferase: 7-phosphate carboxyvinyltransferase: dehydratase: ARO1 kinase: ARO1 ALD2 reductase: ARR2 polyamine [+ 2 isozymes] TRM82 TRM8 synthase: DUS4 [+ 5 isozymes] aconitase: ACO1 YDL086W ATP synthase: ARO2 TYR1 synthase: ARO1 ARO1 superpathway of L- 3-carboxypropyl]-KTI11 DPH2 DPH1 acetyltransferase: hydrolyzing): ASN1 c oxidoreductase: 8-oxo-dGTP 8-oxo-GTP synthase system: dehydrogenase α NOP2 synthase: ILV2 ILV6 deaminase: CHA1 synthase: LYS20 adenylyltransferase: thioadenosine ARO8 ARO1 asparagine 2 -1,2- glucosidase: SGA1 a 1-acyl-2- synthase: ARO3 oxidase: FMS1 an N 7 phosphoribosyltransferase: HIS1 threonine ammonia- (2R)-homocitrate MET3 3-deoxy-7- serine and glycine L-histidine- MET2 (S)-lactate DLD1 FAS2 FAS1 (ascorbate): GRX1 mannosidase: MNL1 - YKL092C 3-(4-hydroxyphenyl) 5-enolpyruvoyl- shikimate synthase (glutamine- arachidonoyl- a 5-methylcytosine 2870 a 5,6-dihydrouracil 20a lyase: ILV1 phosphoheptulonate 3-dehydroshikimate shikimate [translation arsenite arsenite 8-oxo-dGTP an alcohol methylguanine 46 MeOH an alcohol D-threo-isocitrate (indol-3-yl)acetate ferroheme a 2-maleylacetate 5’-methylthioadenosine chorismate tyr pyruvate 3-dehydroquinate biosynthesis I hydrolyzing): ASN2 pyruvate phosphatidylinositol in 25S rRNA in tRNA (S)-2-acetolactate shikimate 3-phosphate elongation factor 2] O-acetyl-L- diphosphatase: in tRNA β (2Z)-2-aminobut- APS synthase: ARO4 asn L-lactate Man 7 GlcNAc 2 - YHR126C 1-(5-phospho- - phosphorylase: MEU1 3-phosphate homoserine hydrogen sulfide 4-phosphate 3-deoxy-D-arabino- 3-phospho-D-glycerate diphthine dehydrogenase: PCD1 β-D-mannopyranose [protein] (isomer D-glucopyranose a glycogen D-ribosyl)-ATP acetohydroxyacid 2-enoate an L-cysteine- arsenite a long-chain chorismate anthranilate heptulosonate 3-phosphoglycerate synthase: DPH5 CYB2 L-ascorbate GSSG 7A B ) 3-acetamidopropanal spermidine adenylylsulfate S-conjugate antiporter: ARR3 fatty acyl-CoA 1,2,3 3 phosphoribosyl-ATP reductoisomerase: synthase: 7-phosphate 8-oxo-dGMP 8-oxo-GMP 5-MTR-1-P mutase: ARO7 dehydrogenase: SER33 O-acetylhomoserine glycine pyrophosphatase: ILV5 cis-homoaconitate kinase: MET14 3-phosphoglycerate a diphthine methyl YKL051W TRP2 TRP3 biosynthesis pyruvate cysteine-S- dehydrogenase: SER3 ester-[translation sulfhydrylase: HIS4 (2R)-2,3-dihydroxy- hypusine conjugate β- arsenite arsenic triglutathione MethylthioRibose- 3-phosphooxypyruvate elongation factor 2] MET17 from glyoxylate a CDP-1-acyl- 1-(5-phospho-β- 3-methylbutanoate PAPS prephenate biosynthesis lyase: STR3 a (1->4)-α-D-glucan (5Z,8Z,11Z,14Z,17Z)- maltotriose a cytosine 2278 a [cytochrome a uridine 2791 a uracil 2843 a monocarboxylic 2-iminobutanoate homoaconitate 1-phosphate anthranilate arginine biosynthesis methylated putative myo-inositol 2-arachidonoyl- a phosphatidylcholine a sterol 4-nitrobenzaldehyde N,N-dimethylaniline reduced riboflavin a uridine 31 in tRNA leukotriene A 4 4-coumarate icosapentaenoyl-CoA in 25S rRNA c]-L-lysine in 21S rRNA in 25S rRNA acid amide YHL008C D-ribosyl)-AMP hydratase: LYS4 Isomerase: MRI1 diphthine glyoxylate arsenite glycerol superpathway phosphoserine cystathionine beta- 4-nitrobenzaldehyde bifunctional dihydroxy-acid L-homocysteine alanine--glyoxylate transport: YCF1 25S rRNA [cytochrome 21S rRNA 25S rRNA phosphoribosyl- phosphoadenosine S-methyl-5- anthranilate of L-cysteine spermidine transaminase: SER1 methylhydrolase: lyase: YHR112C reductase: YDL124W N,N-dimethylaniline chorismate tRNA 4-coumarate YJL170C dehydratase: ILV3 N-acetylglutamyl- cysteine-S- NADPH- (cytosine 2278 -C 5 )- c]-lysine N- (uridine2791-2’-O) (uracil 2843 -N 3 )- amidase: NTA1 leukotriene A4 (1R,2S)- thio-D-ribulose RRT2 aminotransferase: 31 AMP phosphosulfate phosphoribosyl biosynthesis (fungi) conjugate β- monooxygenase: synthase/riboflavin pseudouridine decarboxylase: homoisocitrate phosphate deoxyhypusine a diphthine- AGX1 CDP-diacylglycerol- Lecithin IsoMAltase: IMA2 IsoMAltase: IMA2 dependent alcohol methyltransferase: methyltransferase: methyltransferase: methyltransferase: amidase: AMD2 hydrolase: LAP2 cyclohydrolase: HIS4 reductase: MET16 1-phosphate transferase: TRP4 arsenic triglutathione acyl-CoA FMO1 reductase synthase: PUS6 FDC1 1-(5-phospho-β-D-ribosyl)- 3-methyl-2- synthase: DYS1 5-methyltetrahydropteroyltriglutamate--homocysteine lyase: IRC7 -inositol 3- cholesterol acyl [+ 6 isozymes] [+ 6 isozymes] dehydrogenase: RCM1 CTM1 MRM2 BMT6 N-(5- O-phospho-L-serine [translation gly thioesterase: TES1 [NAD(P)H]: ARO2 5-[(5-phosphoribosylamino) oxobutanoate homo-isocitrate Methylthioribulose- L-homoserine phosphatidyltransferase: PIS1 transferase: LRO1 ADH6 a 2’-O- an N 3 - 2-oxobutanoate phosphoribosyl) elongation factor 2] S-methyltransferase: MET6 a thiol N,N-dimethylaniline- a 5-methylcytosine 2278 a [cytochrome c]- a pseudouridine 31 dehydrogenase: 1-phosphate γ dehydrospermidine 4-nitrobenzyl alcohol riboflavin methyluridine 2791 methyluracil 2843 a monocarboxylate leukotriene B 4 4-vinylphenol methylideneamino]imidazole- L-homoserine sulfite N-acetyl- - diphthamide N-oxide in 25S rRNA N 6 -methyl-L-lysine in tRNA YGR221C LYS12 DEhydratase: MDE1 -anthranilate acetylglutamate in 21S rRNA in 25S rRNA YIL140W 4-carboxamidephosphoribosyl-5-amino- alpha- L-valine:2- N-(5’- glutamyl-phosphate synthase: RRT2 acetolactate 5-(methylsulfanyl) synthase: ARG2 phosphoserine Carboxylate Degradation a 1-acyl-2- α 1-phosphoribosyl-4- isopropylmalate oxoglutarate homoserine O- phosphoribosyl) homoserine O- L-glutamate N- reductase: ARG5,6 deoxyhypusine diphthine--ammonia met CMP a 1-acyl-sn-glycero- a (1->4)- -D-glucan D-glucopyranose (5Z,8Z,11Z,14Z,17Z) D-glucopyranose maltose 2-oxoadipate sulfite reductase: phosphatase: SER2 arachidonoyl- a steryl-ester coenzyme A imidazolecarboxiamide: synthase, minor aminotransferase: synthase: ILV2 ILV6 -2,3-dioxopentyl -anthranilate acetyltransferase: acetyltransferase: acetylglutamate synthase: DYS1 ligase: DPH6 acetyltransferase: MET10 MET5 N-acetyl-L- ammonia 3-phosphocholine -icosapentaenoate HIS6 isozyme: LEU9 BAT1 1-phosphate 1-(2-isomerase: TRP1 MET2 ARG7 N-acetyl-L-kinase: ARG5,6 a [deoxyhypusine a diphthamide- oxalate phosphatidylinositol alpha- branched-chain 2-aminoadipate MET2 glu glutamate 5- assimilation cycle I (S)-2-aceto-2- carboxyphenylamino) glutamate synthase]-N-(4- [translation degradation VI pyruvate pyruvate decarboxylation acetate phosphoribulosylformimino- isopropylmalate amino acid transaminase: acireductone acetylornithinesemialdehyde ser hydroxybutanoate -1-deoxy-D- elongation factor 2] fermentation to acetyl CoA conversion AICAR-phosphate YER152C O-acetyl-L- hydrogen sulfide aminobutylidene) YIL088C synthase: LEU4 transaminase: BAT2 2-aminoadipatee:2- synthase: UTR4 O-acetyl-L- gln aminotransferase: to acetate VIII a very-long- YGR131W ribulose 5-phosphate -lysine serine a [pyruvate to acetyl-CoA a 1,2-diacyl- isomaltose a 3-sn-phosphatidyl- a uracil 2634 an adenine 34 acetohydroxyacid oxoglutarate homoserine indole-3-glycerol homoserine ARG8 glu oxalate a phospholipid lauroyl-CoA malonyl-CoA H + a 3’-phosphopolynucleotide a guanine 37 in tRNA R’C(R)SH [histone]-L-arginine riboflavin 4-guanidinobutyramide chain (3R)-3- glycolate ethanol ammonium dehydrogenase sn-glycerol L-serine L-homocysteine in 25S rRNA in tRNA reductoisomerase: 1,2-dihydroxy-5- deoxyhypusine hydroxymethyltransferase: L-phenylalanine hydroxyacyl-CoA imidazoleglycerol- (2S)-2- aminotransferase: phosphate carbamoyl- acetylornithine pyruvate acetate S-adenosylmethionine- bifunctional ILV5 (methylsulfanyl) synthase: DYS1 SHM2 biosynthesis I oxalate--CoA E2 protein] N 6 - 25S rRNA phosphate isopropylmalate val ARO8 synthase: TRP3 hydrogen sulfide phosphate acetyltransferase: glycine pyruvate carboxy- acetyl CoA tRNA (guanine 37 -N 1 protein arginine N- chorismate very-long-chain tRNA(adenine34) alcohol O-acetylhomoserine pent-1-en-3-one an [eIF5A- ligase: PCS60 lipoyl-L-lysine homocysteine S- polynucleotide 3’- amidase: NTA1 (uracil 2634 -N 3 )- glyoxylate synthetase: ARG7 glutamine )-methyltransferase: thiol oxidase: ERO1 methyltransferase: synthase/riboflavin 3-oxoacyl-CoA deaminase: dehydrogenase synthase: HIS7 (R)-2,3-dihydroxy- (1S,2R)-1-C- hydroxymethyltransferase: lyase: PDC6 dihydrolipoamide pyruvate synthetase: ACS2 oligo-1,6- methyltransferase: SAM4 reductase: GOR1 sulfhydrylase: precursor]-N-(4- pyruvate acetyl CoA phosphatidylserine phosphatase: TPP1 amidase: AMD2 methyltransferase: BZZ1 isopropylmalate 3-methylpentanoate L-2-aminoadipate acireductone (indol-3-yl)glycerol CPA1 CPA2 SHM1 chorismate synthetase: GLN1 oxalyl-CoA dehydrogenase: dehydrogenase: phospholipid:diacylglycerol 3-oxomyristoyl- glucosidase: IMA4 S-Methylmethionine TRM5 HSL7 reductase reductase: IFA38 TAD2 TAD3 II: ADH2 MET17 O-acetylhomoserine aminobutylidene) decarboxylase: PDC5 sn-1 acylhydrolase: BMT5 D-erythro-1- isomerase: LEU1 dioxygenase: ADI1 N-acetyl-L-ornithine PDB1 PDA1 synthetase: ACS1 acyltransferase: LRO1 CoA synthase: ELO1 [+ 4 isozymes] Homocysteine [NAD(P)H]: ARO2 3-phosphate carbamoyl L-ornithine -lysine pyruvate carboxy- LPD1 ATG15 a generic an N 1 - an N 3 - AICAR sulfhydrylase: gly chorismate a [pyruvate a [pyruvate acetyl-CoA methylTransferase: MHT1 [histone]-N ω- a very-long-chain a hypoxanthine YaPSin (imidazol-4-yl)- dihydroxy-acid phosphate L-glutamate polynucleotide methylguanine 37 R’C(R)S-S(R)CR’ reduced riboflavin 4-guanidinobutanoate methyluracil 2634 34 glyoxylate acetaldehyde L-2-aminoadipate MET17 deoxyhypusine mutase: ARO7 oxalyl-CoA lyase: PDC1 dehydrogenase dehydrogenase methyl-arginine oxoacyl-CoA in tRNAs glycerol 3-phosphate dehydratase: ILV3 4-(methylsulfanyl) tryptophan gln acetaldehyde met substrate in tRNA in 25S rRNA 2-isopropylmaleate synthase: DYS1 2-oxoglutarate biosynthesis III decarboxylase: PXP1 E2 protein] N 6enzyme- E2 protein] N 6 -S- reductase: LYS2 -2-oxobutanoate imidazole glycerol- synthetase: TRP5 prephenate -dihydrolipoyl- α-D-glucopyranose D-glucopyranose an [eIF5A- L-proline acetaldehyde:NADP+ dihydrolipoyllysineacetyldihydrolipoyl- D-gluconate a 2-acyl-1-lyso- phosphate (S)-3-methyl-2- L-2-aminoadipyl- a lyso-phospholipid a triacyl-sn-glycerol 3-oxomyristoyl-CoA a fatty acid YGR031C-A ornithine L-lysine acetyltransferase: L-lysine phosphatidylserine isopropylmalate oxopentanoate [LYS2 L-2- precursor]- biosynthesis 2-oxoglutarate formyl-CoA oxidoreductase: ALD6 degradation dehydratase: HIS3 carbamoyltransferase: prephenate glutamate glutamate dehydrogenase 1 aldehyde LAT1 isomerase: LEU1 aminoadipyl- indole deoxyhypusine I (from L- 3-(imidazol-4- L-isoleucine:2- ser ARG3 L-homoserine synthase: GLT1 L-homocysteine L-alanine glutamate) dehydratase: PHA2 (NADP-dependent): GDH1 dehydrogenase: ALD4 yl)-2-oxopropyl oxoglutarate carrier-protein] biosynthesis Ligand of glutamate dehydrogenase 2 aldehyde dehydrogenase D-gluconate YGL045W (2R,3S)-3- L-homocysteine biosynthesis II a [histone H3] N 6 an O 6 - 2-O-(6-phospho- an [amino-group carrier a [phosphatase phosphate aminotransferase: eIF5A: LIA1 (NADP-dependent): GDH3 (NADP+): ALD5 a [protein]- β a guanosine 2922 a [histone 4-methylbenzyl a [protein]-L- L-2-aminoadipate 3-phenyl-2- gluconokinase: 6 6 a 1,3- -D-glucan α γ a phenolic donor 4-coumaryl alcohol a folate benzyl alcohol isopropylmalate BAT1 a 2-oxo carboxylate glu L-malate 2-oxoglutarate ,N ,N -trimethyl- methylguanine -D-mannosyl) protein]-C-terminal- - 2A protein] C- nitric oxide ω acetamide histidinol-phosphate reductase: LYS2 cystathionine tryptophan glu glu acetyl-CoA L-cysteine in 27S pre-rRNA H3]-L-lysine-4 alcohol proline ( = 180) YGR213C branched-chain met putative glutamate oxopropanoate acetate YDR248C L-lysine-36 in DNA -D-glycerate (L-ornithyl)-L-glutamate histone H3 lysine-4 N terminal L-leucine 3-isopropylmalate β β synthetase: TRP5 asp pyruvate degradation II 27S pre-rRNA aminotransferase: amino acid -lyase: STR3 cystathionine - L-citrulline an [eIF5A]-hypusine 5-kinase: YHR033W L-phenylalanine:2- formate D-gluconate putative thioredoxin aryl-alcohol Resistant to aryl-alcohol dehydrogenase putative cystathionine transaminase: ALT2 -trimethyltransferase: 4-coumaryl alcohol leucine carboxy putative HIS5 transaminase: BAT2 synthase: CYS4 β cystathionine β- gamma-glutamyl oxoglutarate 6-phosphate acetylornithine (guanosine2922-2’-O) peroxidase: SCO2 dehydrogenase: dihydrofolate Yeast HemogloBin- Rapamycin dehydrogenase: allysine -lyase: STR3 aspartate alanine [histone-H3]- O-6-MethylGuanine- exo-1,3-beta- SWD2 SWD3 acetyltransferase: methyltransferase: amidase: AMD2 monomer: LEU2 cystathionine beta- methionine-oxo- putative γ kinase: PRO1 transaminase: ARG8 -methyltransferase: thioredoxin AAD10 reductase: DFR1 like protein: YHB1 Deletion: RRD2 AAD15 synthase: CYS4 kinase: HOM3 aminotransferase: -L-glutamyl aminotransferase: formate (S)-malate trimethyl-L-lysine- DNA alpha mannosidase: BRE2 SWD1 SDC1 ATF1 PPM1 amidase: NTA1 L-histidinol lyase: YHR112C trp cystathionine beta- arginosuccinate glucanase: SPR1 an [amino-group SPB1 peroxidase: DOT5 [+ 4 isozymes] [+ 14 isozymes] [+ 4 isozymes] (2S)-2-isopropyl- ile saccharopine cysteine-S- acid transaminase: 5-phosphate ARO8 dehydrogenases: malate a [phosphatase ALT1 36 demethylase: methylTransferase: [+ 3 isozymes] AMS1 a 2-O- SHG1 SET16 SPP1 YFL026W phosphate dehydrogenase lyase: YHR112C synthetase: ARG1 L-aspartyl- carrier protein]-C- a [histone H3] N 2A protein] C- YGR125W 3-oxosuccinate conjugate beta- AAT2 L-threonine cysteine-S- ala FDH1 dehydrogenase: RPH1 MGT1 a phenoxyl radical a [protein]-L- gamma-glutamyl γ methylguanosine 2922 ,N 6 ,N 6 -trimethyl- coumaryl acetate 4-methylbenzaldehyde a 7,8-dihydrofolate nitrate benzaldehyde acetate (NADP+, L- lyase: IRC7 biosynthesis 4-phosphate phe MAE1 terminal- -(L-glutamate of a phenolic donor terminal L-leucine proline (ω = 0) conjugate beta- glycine biosynthesis II in 27S pre-rRNA L-lysine-4 glutamate- 4-(methylsulfanyl) aspartate β-alanine phosphate 5-semialdehyde- methyl ester histidinolphosphatase: a proteinogenic lyase: IRC7 CO 2 pyruvate -2-oxobutanoate L-arginino-succinate aspartic beta reductase: PRO2 β α HIS2 forming): LYS9 biosynthesis biosynthesis a [glycine-cleavage ethanol Alcohol Degradation 6 a 1,3- -D-glucan -D-glucopyranose D-mannopyranose 2-yl)-L-glutamate amino acid semi-aldehyde ethylene glycerophosphodiester a [histone H3] N - a [protein]-S- L-cystathionine complex H protein] degradation II formaldehyde succinate a guanine in DNA 6-phosphate D-glycerate L-homoserine degradation methyl-L-lysine-36 methyl-L-cysteine L-saccharopine argininosuccinate dehydrogenase: L-glutamate-5- dihydrolipoamide glycol 4-methyl-2- cystathionine L-cystathionine N 6 -dihydrolipoyl- YGL173C histidinol serine pyruvate HOM2 spermine degradation homoserine lyase: ARG4 semialdehyde L-lysine dehydrogenase: YEL017C-A oxopentanoate biosynthesis saccharopine gamma- cystathionine pyruvate cystathionine ethanol kinase: THR1 L-aspartate 4- LPD1 7-[4-methoxy-(2- L-leucine:2- lyase: CYS3 carboxylase: PYC1 spermine aminomethyltransferase: alcohol a glycerophosphodiester an N 3 - from glyoxylate dehydrogenase cystathionine γ- gamma- gamma- cystathionine ethylene glycol histidinol pyruvate O-phospho- semialdehyde oxidase: FMS1 glycerophosphodiesterase: a chitodextrin hydroxy-3-amino- 4-phosphooxy- an N-terminal L- a guanine 1575 3-methylbenzyl an organic sn-glycerol oxoglutarate (NAD+, L-lysine- lyase: CYS3 lyase: CYS3 GCV1 dehydrogenase protoheme A NADPH H + methyladenine a DNA segment NaMN wound RNA glyoxylate acrylamide dehydrogenase: HIS4 synthase: STR2 glycine carboxylase: PYC2 L-homoserine cystathionine γ- gamma- arg GDE1 3-carboxypropyl) L-threonine glutaminyl-[protein] in 18S tRNA alcohol hydroperoxide 3-phosphate aminotransferase: forming): LYS1 [+ 2 isozymes] L-alanine a [glycine-cleavage a [glycine- IV: ADH4 glycolaldehyde phosphatidylglycerol in DNA gly biosynthesis oxaloacetate synthase: STR2 lyase: CYS3 homoserine 3-aminopropanal ethanol ]-wyosine 37 protein N-terminal 18S rRNA BAT1 complex H protein] Nglycine6 -cleavage complex reductase: YLL056C aryl-alcohol 3-ethylmalate branched-chain serine cys biosynthesis III [+ 2 isozymes] dehydrogenase: dehydrogenase: phospholipase C: PGC1 (R,R)- in tRNA7-(2-hydroxy-3-amino-Phe glycerol-1- RNA-dependent YFR029W from threonine (S)-1-pyrroline- phosphoserine IMP 5’- glutamine (guanine 1575 -N 7 )- alkyl hydroperoxide amidase: NTA1 D-sorbitol D-sorbitol lys aspartate 3-aminopropanal:NAD(P) aminomethyldihydrolipoyl-dehydrogenaseH protein] N 6 -[(R sn-glycerol 3-phosphate recombinase: DMC1 dehydrogenase: synthase: MLS1 histidinal amino acid hydroxymethyltransferase: threonine HOM6 ADH2 glycolaldehyde butanediol NADPH 3-methylcarboxypropyl) phosphatase: GPP1 ATPase: RRP3 3-ethylmalate YNR072W cys 5-carboxylate L-lysine )-lipoyl]-L-lysine endochitinase: CTS1 DNA-3- transaminase: SER1 [+ 2 isozymes] nucleotidase: ISN1 amidohydrolase: methyltransferase: AAD10 reductase: AHP1 glycerol-1- amidase: AMD2 D-mannitol D-mannitol SHM2 aminotransferase: synthase: THR4 + oxidoreductase: ALD2 (decarboxylating) acetaldehyde degradation heme oxygenases: [+ 4 isozymes] [+ 10 isozymes] transaminase: BAT2 3-aminopropanal:NAD(P) aldehyde dehydrogenase: OYE3 ChiTinaSe: CTS2 methyladenine -wyosine NTA1 BUD23 TRM112 phosphatase: GPP2 synthase: DAL7 glycine thr cys AAT2 pyrroline-5- : GCV2 HMX1 NADPH histidinol aspartate methyltransferase: PPM2 an N 7 - hydroxymethyltransferase: L-homoserine + oxidoreductase: ALD3 C1 Compound Utilization and Assimilation aldehyde dehydrogenase: ALD4 glycerol-3-phosphate dehydrogenase: OYE2 glycosylase: MAG1 2-hydroxy- (3R)-3-hydroxy-2-oxo- a DNA segment in an N-terminal L- carboxylate (R,R)-2,3-butanediol β 1575 an alcohol glycerol acrylate dehydrogenase: HIS4 leu L-threonine L-cysteine aminotransferase: dehydrogenase: aldehyde dehydrogenase -D-ribosylnicotinate methylguanine 3-methylbenzaldehyde an unwound RNA 3-ethylmalate D-sorbitol D-sorbitol SHM1 thr reductase: PRO3 dehydrogenase: GUT2 (R,R)-butanediol wybutosine 37 4 phosphooxybutanoate reverse orientation glutamyl-[protein] YJR158W ser aldolase: GLY1 desulfurase: AAT1 β-alanine ALD4 (NAD+): ALD5 in 18S rRNA D-mannitol D-mannitol YFL040W formaldehyde aldehyde aldehyde:NAD+ dehydrogenase: N,N’- N,N’,N’’- in tRNA Phe NFS1 ISD11 CO 2 formaldehyde formate oxidation II formate assimilation into 5,10- an apurinic dehydrogenase oxidoreductase: ALD3 DHAP BDH1 (Z,Z)-biliverdin-IX α 2+ NADP + diacetylchitobiose triacetylchitotriose 3-methyladenine his gly ala asp pro gly oxidation II oxidation aldehyde:NAD+ CO Fe A(H2) (glutathione- methylenetetrahydrofolate (NAD+): ALD5 (R)-acetoin site within DNA (glutathione- to CO miltefosine miltefosine dependent) 2 oxidoreductase: ALD2 D-sorbitol YEL069C dependent) acetate D-sorbitol formate D-mannitol D-mannitol formaldehyde formate glycolate 6 -L- YER185W formate--tetrahydrofolate formaldehyde 1,2-dihydroxy-5- an N uridine 2’3’-cyclic formate acetyl CoA a double a [protein]- sn-glycerol (methylsulfanyl) N 8 -acetylspermidine threonylcarbamoyladenine 37 a uracil in DNA cycloartenol nicotinamide oxaloacetate glycerol L-glyceraldehyde acetaldehyde D-mannitol cis-dienelactone ligase: MIS1 stranded DNA monophosphate L-histidine formate--tetrahydrofolate dehydrogenases: synthetase: ACS2 pent-1-en-3-one in tRNAtRNA D glyceraldehyde L glyceraldehyde 1-phosphate mannitol 2- D-sorbitol D-sorbitol acetyl CoA 2’,3’-cyclic- YDL245C ligase: ADE3 FDH1 reductase: YPR1 reductase: YPR1 NADPH- dehydrogenase: D-mannitol D-mannitol S-(hydroxymethyl) an N 10 - synthetase: ACS1 threonylcarbamoyladenosine sterol 24-C- Nicotinamide N- nucleotide 3’- NADPH- glycerol-1- dienelactone CO exodeoxyribonuclease phosphoenolpyruvate Synthetic Lethal of NADPH- dependent alcohol glutathione formyltetrahydrofolate S-(hydroxymethyl) 2 dehydratase: TCD1 methyltransferase: methylTransferase: phosphodiesterase: phosphatase: GPP1 MAN2 hydrolase: acireductone tRNA V: EXO5 carboxykinase: PCK1 N-end rule: SLN1 dependent alcohol dependent alcohol glycerol-1- dehydrogenase: mannitol 2- S-hydroxymethyl- trifunctional formate- glutathione acetyl-CoA N8-acetylspermidine Uracil DNA N- ERG6 NNT1 CPD1 YDL086W YER060W dioxygenase (Ni2+- threonylcarbamoyladenosine dehydrogenase: dehydrogenase: phosphatase: GPP2 ADH6 dehydrogenase: glutathione tetrahydrofolate ligase/ S-hydroxymethyl- oxidase: FMS1 Glycosylase: UNG1 requiring): ADI1 a cyclic Ndehydratase:6 -L- TCD2 2’-UMP ADH6 ADH6 DSF1 dehydrogenase: methenyltetrahydrofolate glutathione phosphoenol a [protein]-N- glycerol threonylcarbamoyladenosine a 5’-phosphooligonucleotide 24-methylenecycloartanol 1-methylnicotinamide D-glyceraldehyde glycerol ethanol keto-D-fructose 2-maleylacetate YDR349C SFA1 cyclohydrolase/ dehydrogenase: pyruvate phospho-L-histidine 37 in tRNA methylenetetrahydrofolate SFA1 S-formylglutathione 3-(methylsulfanyl) an apyrimidinic uracil methenyltetrahydrofolatedehydrogenase: ADE3 S-formylglutathione CO formate 4-acetamidobutanal propane-1,3-diamine YDR461W propanoate site in DNA cyclohydrolase: MIS1 S-formylglutathione a 5,10- hydrolase: YJL068C S-formylglutathione a carboxylate YPL058C a carboxylate methenyltetrahydrofolate hydrolase: YJL068C a [histone H3] N 6 α cytidine 2’,3’-cyclic 5-chloro-trans sucrose 6 G 2-deoxy- -D- D-sedoheptulose α methylenetetrahydrofolate 2-oxoglutarate 6 6 a homogalacturonan trans-aconitate uroporphyrinogen-I a (1->4)- -D-glucan dihydroxyacetone D-ribofuranose L-iditol ,N ,N -trimethyl- -phosphate a 3-dehydrosphinganine ribose 1-phosphate monophosphate 1,7-bisphosphate NMN a nitrile YDR348C formate dehydrogenase -dienelactone formate Inorganic Nutrient Metabolism L-lysine-4 2’,3’-cyclic- IMP 5’- (NADP + ): ADE3 1,4-alpha-glucan dihydroxyacetone Unknown: SOR2 methylenetetrahydrofolate trans-aconitate 3- nucleotide 3’- uroporphyrinogen SedoHeptulose 1,7- nucleotidase: ISN1 sorbitol formate carboxymethylenebutenolidase: 3-dehydrosphinganine phosphoribomutase: β-nicotinamide branching kinase: DAK1 ribokinase: RBK1 nitrilase: NIT3 YDR090C dehydrogenase endo- methyltransferase: phosphodiesterase: decarboxylase: Bisphosphatase: dihydroxyacetone dehydrogenase: dehydrogenases: urea cycle [histone H3]- YDL086W reductase: TSC10 PRM15 enzyme: GLC3 [+ 2 isozymes] (NADP + TMT1 CPD1 HEM12 SHB17 D-ribonucleotide kinase: DAK2 ): MIS1 thiosulfate phosphate polygalacturonase: invertase: SUC2 SOR1 FDH1 lysine-4 1-(β-Dphosphatase: PHO8 a (1,6)-α-D- a 5,10- disproportionation acquisition PGU1 (E)-2- 2-deoxy-D-ribose D-ribofuranose demethylase: JHD2 2’CMP D-sedoheptulose ribofuranosyl) glucosyl-(1,4) DHAP keto-L-sorbose YDR104C methylenetetrahydrofolate III (rhodanese) 5-chloromaleylacetate a sphinganine (methoxycarbonylmethyl) coproporphyrinogen I a carboxylate CO 2 5-phosphate 7-phosphate α 5-phosphate arg nicotinamide - -glucan a phosphate butenedioate thiosulfate monoester a homogalacturonan a homogalacturonan β β-D-glucose acid phosphatase: a [histone -D-fructofuranose formaldehyde succinate 6-phosphate YDL199C ammonium DET1 H3]-L-lysine-4 YDL229W bifunctional RhoDanese-Like [+ 5 isozymes] arginase: CAR1 carbamoylphosphate protein: RDL1 phosphate thiosulfate UDP-N-acetyl- CTP dTTP argininosuccinate synthetase/aspartate α a 1-phosphatidyl- 2-chloro-cis- 2-deoxy-D-glucose 3-chloro-1-phenyl- sulfurtransferase: -D-glucosamine seleno-L- 3-dehydrosphinganine a guanine 26 in tRNA galactitol chitin 5-methylcytosine maltose a chitodextrin cinnamate lyase: ARG4 transcarbamylase: dienelactone a protein 1-propanone TUM1 1D-myo-inositol homocysteine 6-phosphate D-galactose dTTP URA2 proteasome endopeptidase CTP diphosphatase: L-arginino-succinate L-ornithinecarbamoyl- reductase: GRE3 diphosphatase: complex: SEM1 RPN12 RPN11 tRNA (guanine 26 -N 2 ) 2-deoxyglucose-6- NPP1 3-chloro-1-phenyl- trans cinamate YDL012C YDL035C phosphate thiosulfate carboxymethylenebutenolidase: 3-dehydrosphinganine NADPH- ChiTinaSe: CTS2 5-methylcytosine IsoMAltase: IMA2 putative 5-methyltetrahydropteroyltriglutamate- RPN9 RPN8 RPN7 RPN6 RPN5 -dimethyltransferase: phosphatase: DOG2 [+ 2 isozymes] 1-propanone NPP1 decarboxylase: thiocyanate sulfite disproportionation GlycosylPhosphatidylInositol YDL086W dependent alcohol endochitinase: CTS1 [+ 6 isozymes] chitinase: CTS2 [+ 2 isozymes] synthetase: homocysteine S- RPN3 RPN10 RPT1 RPT2 RPT3 reductase: TSC10 2-deoxyglucose-6- deaminase: FCY1 arginosuccinate I (thiol-dependent) anchoring biosynthesis: GPI1 TRM1 reductase: GRE2 dehydrogenase: FDC1 CPA1 CPA2 methyltransferase: MET6 RPT4 RPT5 RPT6 RPN13 RPN2 phosphatase: DOG1 CMP dTMP synthetase: ARG1 GPI2 SPT14 GPI15 GPI19 ERI1 an N 2 ADH6 N,N’- carbamoyl RPN1 PRE5 PRE8 PRE2 PRE6 (S)-3-chloro-1- a chitodextrin thymine D-glucopyranose thiosulfate 2-chloromaleylacetate L-threo-sphinganine dimethylguanine 26 2-deoxy-D-glucose D-galactopyranose diacetylchitobiose styrene ornithine phosphate α PRE1 PRE3 PRE7 PRE4 PUP2 phenyl-1-propanol thiosulfate--thiol a 6-(N-acetyl- - SeMet in tRNA YCR021C carbamoyltransferase: D-glucosaminyl) UDP PRE9 PUP3 PUP1 SCL1 PRE10 ARG3 sulfurtransferase: a peptide YCR011C RDL2 -1-phosphatidyl- 1D-myo-inositol L-citrulline sulfite

α-D-galacturonosyl- a β-D-glucan an unbranched α- UTP 2’-deoxycytidine dCTP YCL027W phosphatidylglycerolphosphate 2,5-dichloro-trans 2-chloro-trans a 1,3-β-D-glucan 3-(hydroxymethyl) (1->4)-α-D- a (1->4)-α-D-glucan with a C3- L-arabinitol glycerol D-ribulose (1,6)-D-mannan 5-fluorocytosine (1-oleoyl, 2-palmitoyl) -dienelactone -dienelactone -5-methylphenol galacturonate substituted glucose dCTP putative mannan UTP diphosphatase: YBL091C-A putative aryl-alcohol endo- 1,4-glucan-6- 2’-deoxycytidine L-arabinose glycerol 2- diphosphatase: endo-1,6-alpha- NPP1 Daughter Specific D-ribulokinase: carboxymethylenebutenolidase: carboxymethylenebutenolidase: putative glucan dehydrogenase: polygalacturonase: [+ 2 isozymes] (1,4-glucano)- deaminase: CDD1 5-fluorocytosine reductase: YPR1 dehydrogenase: NPP1 phosphatidylglycerophosphatase: GEP4 mannosidase: DFG5 Expression: DSE4 [+ 2 isozymes] YDR109C YDL086W YDL086W endo-1,3-beta- Defective Cell AAD15 PGU1 transferase: GLC3 deaminase: FCY1 [+ 2 isozymes] GCY1 YBR140C D-glucosidase: Wall: DCW1 [+ 4 isozymes] α UMP 2’-deoxyuridine dCMP a 1,6- -D- 5-fluorouracil D-ribulose 1-oleoyl-2-palmitoyl- SCW11 3-hydroxy-5- D-galactopyranuronate a glycogen a β-D glucan L-arabinopyranose dihydroxyacetone 2,5-dichloromaleylacetate 2-chloromaleylacetate mannosyloligosaccharide 5-phosphate phosphatidylglycerol methylbenzaldehyde YBR086C a 1,3-β-D-glucan D-glucopyranose

ATP ferrichrome taurine α α ferrichrome A UDP-N- lys lys isethionate a phospholipid methyl -D-glucoside methyl -D-glucoside gly gly ketoconazole crystal violet sn-glycero-3-phospho-1-inositol borate arg arg acetate phosphate phosphate phosphate phosphate phosphate borate spermine spermine spermine spermine myo-inositol myo-inositol a phosphatidylinositol triacetylfusarinine C dityrosine choline glycerol glycerol glycerol glycerol arg arg ammonium ammonium phosphate sulfite acetate acetate arsenate maltose maltotriose maltotriose fluconazole glucosyl-oleandomycin ferrirubin acetyl-D- 10-N-nonyl acridine orange sn-glycero-3-phosphocholine antimonite glycerol acetate ammonium L-cysteate acetate an oligomycin H 2 O H 2 O maltose maltose cefoperazone triacetylfusarinine C glucosamine arsenite [+ 4 more]

DNF3-CRF1 YBR069C YCR088W YDL137W YDR055W YDR164C YDR508C YER060W-A YGL053W YGR143W YHL044W YIL118W YJR151C STErile YLL007C YLR120C YLR229C YLR332W YLR413W YLR452C YOR273C YLL028W YPR156C YGR138C YBL029C-A SUR7 YMR034C YMR177W YPR058W YDL119C YOL103W YDR497C YCL058C YMR244C-A YNL019C YNL090W YNL173C YNL243W YNL283C YNL322C YOL030W YOR046C YOR122C YOR348C YPL224C YNL231C YGR224W YLR266C YHL040C YHL047C YGR281W YEL004W YBR180W YPR198W YPR149W YPL004C RAX1 YOR089C YOL132W YNR074C YCR098C YGL077C YPR201W YDR536W YGL084C YPL189W YFL054C YLL043W YMR279C YJL059W YEL063C YNL270C YOL092W YOR378W YPR138C YDR384C YER053C YML123C YNR013C YIL166C YPL092W YCR098C YNL083W YJR077C YML116W YKL217W YCR010C YPR192W YLL052C P4-ATPase YML123C YJL156C YHR155W phoS YGR023W YFL014W YER103W YDR373W YBR220C YBR298C YJR160C YDL247W YBR129C complex ferrichrome UDP-N- taurine methyl α-D-glucoside methyl α-D-glucoside ketoconazole ferrichrome A acetyl-D- crystal violet sn-glycero-3-phospho-1-inositol glycerol glycerol glycerol glycerol glycerol borate acetate isethionate borate maltose maltotriose maltotriose spermine spermine spermine spermine myo-inositol myo-inositol a phosphatidylinositol triacetylfusarinine C dityrosine choline lys lys ammonium ammonium phosphate phosphate phosphate sulfite phosphate phosphate acetate acetate arsenate gly gly fluconazole glucosyl-oleandomycin ferrirubin glucosamine 10-N-nonyl acridine orange sn-glycero-3-phosphocholine antimonite acetate arg arg ammonium L-cysteate acetate maltose maltose an oligomycin arg arg H 2 O H 2 O a phospholipid cefoperazone triacetylfusarinine C arsenite [+ 4 more] phosphate ATP Copyright 1997-2013 The Board of Trustees of Leland Stanford Junior University, 2013-2020 SRI International. This diagram was automatically generated by SRI International Pathway Tools version 24.0, authors S. Paley and P.D. Karp.