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Conference Book Pharmaceutical Research: from Basic Research to Medical Applications

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Conference Book Pharmaceutical Research: from Basic Research to Medical Applications Annual Meeting of the German Pharmaceutical Society – DPhG Pharmaceutical research: From basic research to medical applications Heidelberg, Germany September 01 – 04, 2019 at Heidelberg University Conference Book Pharmaceutical research: From basic research to medical applications Annual Meeting of the German Pharmaceutical Society 2019 - DPhG Heidelberg, Germany, September 2019 ISBN 978-3-9816225-6-0 Annual Meeting of the German Pharmaceutical Society – DPhG Conference Book Pharmaceutical research: From basic research to medical applications Heidelberg, Germany September 01 – 04, 2019 at Heidelberg University www.2019.dphg.de Institutional Sponsors Förderer der DPhG-Jahrestagung 2019 TABLE OF CONTENTS CONFERENCE COMMITTEES ................................................................................................................................... ii WELCOME ADDRESS ............................................................................................................................................... iii GENERAL INFORMATION ........................................................................................................................................ iv LOCATIONS ................................................................................................................................................................. vi 1 CONFERENCE PROGRAM OVERVIEW .............................................................................................................. 1 2 PLENARY LECTURES ............................................................................................................................................ 11 3 SCIENTIFIC LECTURES ....................................................................................................................................... 17 3.1 New Research, New Researchers I ...................................................................................................... 18 3.2 Ion channels as drug targets ................................................................................................................. 22 3.3 Fachsymposium Dermatopharmakologie: “Predictivity of in vitro tests in pharmacology and toxicology” .............................................................................................................................................................. 26 3.4 Cysteine-reactive inhibitors and probes ............................................................................................. 31 3.5 Dysfunctional Cellular Signaling in Cardiovascular Diseases ....................................................... 34 3.6 Biopharmacy, Pharmaceutical Technology ....................................................................................... 37 3.7 Gold! Hunting treasures in chemistry and pharmacology ............................................................. 41 3.8 Evidence-based value added to innovative health care by pharmacists ..................................... 44 3.9 Simulation in Pharmaceutic and Formulation Development ......................................................... 47 3.10 G-Protein-coupled Receptors ................................................................................................................ 51 3.11 Radiopharmacy & Labeling ................................................................................................................... 55 3.12 Proteomics in Medicine and Pharmacy .............................................................................................. 60 3.13 Microfluidics / Cell-based assays and organoids for drug discovery .......................................... 64 3.14 New Research, New Researchers II ..................................................................................................... 67 3.15 The promise of cure - recent breakthrough innovation in cell- and gene therapy ................... 72 3.16 Natural Products – From Molecular Pharmacology to Clinical Applications ............................. 75 3.17 Bioanalytical Mass Spectrometry ........................................................................................................ 78 3.18 Challenges and opportunities in model based dose adaptation ................................................... 81 4 POSTERS ................................................................................................................................................................. 84 4.1 Medicinal Chemistry and drug design ............................................................................................... 85 4.2 Other Topics .......................................................................................................................................... 120 4.3 Analytics and toxicology ..................................................................................................................... 123 4.4 Cancer ..................................................................................................................................................... 126 4.5 Clinical Pharmacy ................................................................................................................................. 128 4.6 Natural Compounds ............................................................................................................................ 134 4.7 Inflammation ......................................................................................................................................... 136 4.8 Pharmaceutical Technology and biomaterials ............................................................................... 138 4.9 Pharmacology ....................................................................................................................................... 153 4.10 Poster Short Talks ................................................................................................................................ 158 AUTHOR INDEX ..................................................................................................................................................... 167 DPhG Annual Meeting 2019 Conference Book • i CONFERENCE COMMITTEES Scientific committee: Prof. Dr. Christian Klein Prof. Dr. Charlotte Kloft Prof. Dr. Thomas Efferth Prof. Dr. Christoph Friedrich Prof. Dr. Irmgard Merfort Prof. Dr. Peter Gmeiner Prof. Dr. Ulrike Holzgrabe Prof. Dr. Jochen Klein Prof. Dr. Michael Lämmerhofer Prof. Dr. Peter Langguth Prof. Dr. Gerhard Winter Prof. Dr. Thorsten Lehr Prof. Dr. Werner Weitschies Prof. Dr. Angelika Vollmar Prof. Dr. Dr. Peter Ruth Prof. Dr. Hermann Wätzig Prof. Dr. Dr. Achim Schmidtko Prof. Dr. Christoph Friedrich Prof. Dr. Ulrich Jaehde Organization committee: Prof. Dr. Michael Wink Prof. Dr. Christian Klein Prof. Dr. Stefan Wölfl Prof. Dr. Gert Fricker Dr. Gabriele Reich ii • DPhG Annual Meeting 2019 Conference Book WELCOME ADDRESS Dear colleagues, the President of the German Pharmaceutical Society (DPhG) and the Congress Chairman would like to welcome you to Heidelberg and Heidelberg University. Heidelberg as the city of sciences with a unique romantic flair is the ideal location for our international annual DPhG meeting 2019. The meeting is cosponsored by one of our most important partners, the Pharmaceutical Society of Japan (PSJ). The title of this year’s meeting is „Pharmaceutical research: From basic research to medical applications“. A broad range of sessions for oral and poster presentations will cover important aspects of current pharmaceutical research. We are looking forward to exciting talks, presented by many high level speakers – including Nobel Prize winner Prof. Harald zur Hausen - and stimulating discussions. A particularly important part of the meeting is the interaction of younger scientists with other attendees. A dedicated session for poster short-talks will allow selected PhD students to present their work. For excellent young postdocs and group leaders we will have special sessions to give them the opportunity of sharing their research results. Many thanks to the scientific committee headed by Prof. Ch. Klein and the local organization team, to the scientific chairs as well as to the Pharmaceutical Society of Japan (JPS) for the strong support. This abstract book provides all necessary information on the program as well as on the abstracts of the scientific contributions of plenary lectures, scientific lectures, short poster lectures and posters. We are glad to have you here for a stimulating meeting in Heidelberg and hope you will enjoy the scientific program as well as the location. Prof. Dr. Stefan Laufer, DPhG-President Prof. Dr. Michael Wink, Congress Chairman DPhG Annual Meeting 2019 Conference Book • iii GENERAL INFORMATION The Annual DPhG Meeting 2019 takes place at the Hörsaalzentrum Chemie of the Heidelberg University (Im Neuenheimer Feld (INF) 252). LANGUAGE The Conference language is English, no simultaneous translation will be provided. INSTRUCTIONS FOR USING CONFERENCE WLAN If your institution is member of the “eduroam” community, you can use the wireless network “eduroam”. The configuration of your device should be the same as instructed by your home institution. Please use your account and the domain of your home institution. If your institution is not member of the “eduroam” community, you can obtain a guest account and a password at the Conference office. CONFERENCE OFFICE The Conference office is located at the Conference building Im Neuenheimer Feld 252, 69120
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