Research Article Vol. 6, No. 5 / May 2019 / Optica 647 Computational aberration compensation by coded- aperture-based correction of aberration obtained from optical Fourier coding and blur estimation 1, 2 2 3 1 JAEBUM CHUNG, *GLORIA W. MARTINEZ, KAREN C. LENCIONI, SRINIVAS R. SADDA, AND CHANGHUEI YANG 1Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA 2Office of Laboratory Animal Resources, California Institute of Technology, Pasadena, California 91125, USA 3Doheny Eye Institute, University of California-Los Angeles, Los Angeles, California 90033, USA *Corresponding author:
[email protected] Received 29 January 2019; revised 8 April 2019; accepted 12 April 2019 (Doc. ID 359017); published 10 May 2019 We report a novel generalized optical measurement system and computational approach to determine and correct aberrations in optical systems. The system consists of a computational imaging method capable of reconstructing an optical system’s pupil function by adapting overlapped Fourier coding to an incoherent imaging modality. It re- covers the high-resolution image latent in an aberrated image via deconvolution. The deconvolution is made robust to noise by using coded apertures to capture images. We term this method coded-aperture-based correction of aberration obtained from overlapped Fourier coding and blur estimation (CACAO-FB). It is well-suited for various imaging scenarios where aberration is present and where providing a spatially coherent illumination is very challenging or impossible. We report the demonstration of CACAO-FB with a variety of samples including an in vivo imaging experi- ment on the eye of a rhesus macaque to correct for its inherent aberration in the rendered retinal images.