Molecular Organization of Mammalian Meiotic Chromosome Axis Revealed by Expansion STORM Microscopy
Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy Huizhong Xua,1, Zhisong Tonga,1, Qing Yea,b,c,1, Tengqian Suna,1, Zhenmin Honga,1, Lunfeng Zhangd, Alexandra Bortnicke, Sunglim Choe, Paolo Beuzera, Joshua Axelroda, Qiongzheng Hua, Melissa Wanga, Sylvia M. Evansd, Cornelis Murree, Li-Fan Lue, Sha Sunf, Kevin D. Corbettg,h,i, and Hu Canga,2 aWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037; bThe MOE Key Laboratory of Weak-Light Nonlinear Photonics, School of Physics and TEDA Applied Physics School, Nankai University, Tianjin 300071, China; cInterdisciplinary Research Center for Cell Responses, Nankai University, Tianjin 300071, China; dSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093; eDivision of Biological Sciences, University of California San Diego, La Jolla, CA 92093; fDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697; gDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093; hDepartment of Chemistry, University of California San Diego, La Jolla, CA 92093; and iLudwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093 Edited by Jennifer Lippincott-Schwartz, Janelia Farm Research Campus, Ashburn, VA, and approved July 23, 2019 (received for review February 12, 2019) During prophase I of meiosis, chromosomes become organized as of these proteins (10, 12). Major questions remain including how loop arrays around the proteinaceous chromosome axis. As cohesin complexes are linked to the axis core, and how the axis is homologous chromosomes physically pair and recombine, the ultimately integrated into the tripartite SC.
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