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Appendix 1: Search strategy for meta-analysis of association between use of - converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers and the risk of cancer (as supplied by the authors)

MEDLINE

1. ACEi[ALL]

2. "ACE inhibitors"[ALL]

3. "ACE inhibitor"[ALL]

4. "Angiotensin converting enzyme inhibitor"[ALL]

5. "Angiotensin converting enzyme inhibitors"[ALL]

6. 1 or 2 or 3 or 4 or 5

7. ""[NM] OR "alacepril"[ALL]

8. ""[NM] OR "benazepril"[ALL]

9. ""[MH] OR "captopril"[ALL]

10. "ceranapril"[NM] OR "ceranapril"[ALL] OR ""[ALL]

11. ""[MH] OR "cilazapril"[ALL]

12. ""[NM] OR "delapril"[ALL]

13. ""[MH] OR "enalapril"[ALL]

14. ""[MH] OR "fosinopril"[ALL]

15. ""[NM] OR "imidapril"[ALL]

16. ""[MH] OR "lisinopril"[ALL]

17. ""[NM] OR "moexipril"[ALL]

18. Moveltipril[ALL]

19. "CGS 13945"[NM] OR "CGS 13945"[ALL] OR "pentopril"[ALL]

20. ""[MH] OR "perindopril"[ALL]

21. ""[NM] OR "quinapril"[ALL]

22. ""[MH] OR "ramipril"[ALL]

23. ""[NM] OR "spirapril"[ALL]

24. " hydrochloride"[NM] OR "temocapril hydrochloride"[ALL] OR "temocapril"[ALL]

25. ""[NM] OR "trandolapril"[ALL]

26. ""[NM] OR "zofenopril"[ALL]

27. 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26

28. ARB[ALL]

29. "Angiotensin receptor blocker"[ALL]

30. "Angiotensin receptor blockers"[ALL]

31. "Angiotensin receptor antagonist"[ALL]

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors

2

32. "Angiotensin receptor antagonists"[ALL]

33. "Angiotensin II receptor antagonist"[ALL]

34. "Angiotensin II receptor blocker"[ALL]

35. 28 or 29 or 30 or 31 or 32 or 33 or 34

36. ""[NM] OR "candesartan"[ALL]

37. ""[NM] OR "eprosartan"[ALL]

38. ""[NM] OR "irbesartan"[ALL]

39. ""[MH] OR "losartan"[ALL]

40. ""[NM] OR "olmesartan"[ALL]

41. ""[NM] OR "tasosartan"[ALL]

42. ""[NM] OR "telmisartan"[ALL]

43. ""[NM] OR "valsartan"[ALL]

44. 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43

45. 6 or 27 or 35 or 44

46. "neoplasms"[MH] OR "neoplasms"[ALL] OR "cancer"[ALL]

47. "neoplasm"[ALL]

48. "neoplasia"[ALL]

49. "malignancy"[ALL]

50. Malignant[ALL]

51. "carcinoma"[MH] OR "carcinoma"[ALL]

52. "glioma"[MH] OR "glioma"[ALL]

53. "leukaemia"[ALL] OR "leukemia"[MH] OR "leukemia"[ALL]

54. "lymphoma"[MH] OR "lymphoma"[ALL]

55. "melanoma"[MH] OR "melanoma"[ALL]

56. "meningioma"[MH] OR "meningioma"[ALL]

57. "sarcoma"[MH] OR "sarcoma"[ALL]

58. 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 or 55 or 56 or 57

59. 45 and 58

60. "humans"[MH]

61. 59 and 60

ALL = All Fields, MH = MeSH Terms, NM = Substance Name

Limitation : Humans

Date of Search : Jan.13.2011 (1974-Jan.2011)

Result : 1031 articles found

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors 3 EMBASE

1. acei

2. 'ace inhibitors'

3. ''/de

4. 'angiotensin converting enzyme inhibitor'/de

5. 'angiotensin converting enzyme inhibitors'/de

6. 1 or 2 or 3 or 4 or 5

7. 'alacepril'/de

8. 'benazepril'/de

9. 'captopril'/de

10. 'ceronapril'/de

11. 'cilazapril'/de

12. 'delapril'/de

13. 'enalapril'/de

14. 'fosinopril'/de

15. 'imidapril'/de

16. 'lisinopril'/de

17. 'moexipril'/de

18. moveltipril

19. 'pentopril'/de

20. 'perindopril'/de

21. 'quinapril'/de

22. 'ramipril'/de

23. 'spirapril'/de

24. 'temocapril'/de

25. 'trandolapril'/de

26. 'zofenopril'/de

27. 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26

28. arb

29. 'angiotensin receptor blocker'/de

30. 'angiotensin receptor blockers'

31. 'angiotensin receptor antagonist'/de

32. 'angiotensin receptor antagonists'

33. ' antagonist'/de

34. 'angiotensin ii receptor blocker'/de

35. 28 or 29 or 30 or 31 or 32 or 33 or 34

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors 4 36. 'candesartan'/de

37. 'eprosartan'/de

38. 'irbesartan'/de

39. 'losartan'/de

40. 'olmesartan'/de

41. 'tasosartan'/de

42. 'telmisartan'/de

43. 'valsartan'/de

44. 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43

45. 6 or 27 or 35 or 44

46. 'cancer'/de

47. 'neoplasm'/de

48. 'neoplasia'/de

49. malignancy

50. malignant

51. 'carcinoma'/de

52. 'glioma'/de

53. 'leukemia'/de

54. 'lymphoma'/de

55. 'melanoma'/de

56. 'meningioma'/de

57. 'sarcoma'/de

58. 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 or 55 or 56 or 57

59. 45 and 58

60. [humans]/lim

61. [embase]/lim OR [embase classic]/lim

62. 59 and 60 and 61

/de = Mapped terms, /lim = Limitation

Limitation : Humans,

Date of Search : Jan.13.2011 (1979-Jan.2011)

Result : 2835 articles found

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors 5 CENTRAL database (The Cochrane Library)

1. acei [ALL]

2. 'ace inhibitors’ [ALL]

3. 'ace inhibitor' [ALL]

4. 'angiotensin converting enzyme inhibitor' [ALL]

5. 'angiotensin converting enzyme inhibitors' [ALL]

6. 1 or 2 or 3 or 4 or 5

7. alacepril [ALL]

8. benazepril [ALL]

9. captopril [ALL]

10. ceronapril [ALL]

11. cilazapril [ALL]

12. delapril [ALL]

13. enalapril [ALL]

14. fosinopril [ALL]

15. imidapril [ALL]

16. lisinopril [ALL]

17. moexipril [ALL]

18. moveltipril [ALL]

19. pentopril [ALL]

20. perindopril [ALL]

21. quinapril [ALL]

22. ramipril [ALL]

23. spirapril [ALL]

24. temocapril [ALL]

25. trandolapril [ALL]

26. zofenopril [ALL]

27. 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26

28. arb [ALL]

29. 'angiotensin receptor blocker' [ALL]

30. 'angiotensin receptor blockers' [ALL]

31. 'angiotensin receptor antagonist' [ALL]

32. 'angiotensin receptor antagonists' [ALL]

33. 'angiotensin ii receptor antagonist' [ALL]

34. 'angiotensin ii receptor blocker' [ALL]

35. 28 or 29 or 30 or 31 or 32 or 33 or 34

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors 6 36. candesartan [ALL]

37. eprosartan [ALL]

38. irbesartan [ALL]

39. losartan [ALL]

40. olmesartan [ALL]

41. tasosartan [ALL]

42. telmisartan [ALL]

43. valsartan [ALL]

44. 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43

45. 6 or 27 or 35 or 44

46. cancer [ALL]

47. neoplasm [ALL]

48. neoplasia [ALL]

49. malignancy [ALL]

50. malignant [ALL]

51. carcinoma [ALL]

52. glioma [ALL]

53. leukemia [ALL]

54. lymphoma [ALL]

55. melanoma [ALL]

56. meningioma [ALL]

57. sarcoma [ALL]

58. 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 or 55 or 56 or 57

59. 45 and 58

[ALL] = in All Text

Limitation : none

Date of Search : Jan.13.2011 (1979-Jan.2011)

Result : 104 articles found

Appendix to: Yoon C, Yang HS, Jeon I, et al. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ 2011. DOI:10.1503/cmaj.101497. Copyright © 2011 Canadian Medical Association or its licensors