Wall Street View
Top 10 Pipelines
Category Company Products Indications Stages
Best CNS • Dimethyl fumarate • Relapsing-remitting MS • Phase III Pipeline • PEGylated • Relapsing forms of MS • Phase III Interferon beta-1a • Daclizumab • Relapsing-remitting MS • Phase III n Best Infectious • Elvitegravir • HIV infection io• Phase III © ut Disease Pipeline • Cobicistat • Boosting Agent ib • Phase III t tr ad, h for antireitsroviralns lo ig l D dow • GS-7y340r i•aHIV infeacnti on se • Phase III p c rs c al u o• Sofosbuvir er u• sHeCV infescotnion • Phase III m ed per C ris for m tho py Best Late Stage • Doloutegr. aAvuir co • HIV infection • Phase III C ed gle Pipeline or• Alibiigtlutidesin • Type 2 diabetes • Phase III roh t a le e p • Migrailnast HC1 • Fabry disease • Phase III a us d p S ed a•n Sirukumab • Moderately to • Phase III or oris iew f uth y, v severely active ot na pla N U dis rheumatoid arthritis
Best Respiratory • Vilanterol • Chronic obstructive • Phase III Pipeline pulmonary disease • Fluticasone • Monotherapy for • Phase III treating asthma • Anoro • Once-daily bronchodilator • Phase III treatment of COPD • Mepolizumab • Severe uncontrolled • Phase III refractory asthma
Best Vaccine • MAGE-A3 • Melanoma and non-small • Phase III Pipeline cell lung cancer • H5N1 adjuvanted • Influenza A virus • Phase III influenza vaccine • Mosquirix • Malaria • Phase III • Recombinant • Herpes Zoster • Phase III vaccine
4 Canadian Pharmaceutical Marketing l April/May 2013 Wall Street View
Category Company Products Indications Stage
Most Innovative • Serelaxin • Heart failure — Pipeline • LCZ696 • Heart failure — • AIN457 • Psoriasis and MS • Phase III • BKM120 • Various tumours — • LDK378 • Lung cancer — • BKM120 • Breast cancer
Best Diabetes • Tresiba • Once-daily new • Approval Pipeline generation basal insulin 2013 • Ryzodeg • Combo product • Approval insulin degludec/ 2013 insulin aspart • IDegLira • Fixed-ratio combination • Phase IIIa of Tresiba and Victoza • FIAsp • Faster acting version of • Phase I NovoRapid
Best Mid Stage/ • PD-0332991 • CDK4-amplified • Phase II Early Stage Pipeline liposarcoma and possibly advanced breast cancer • PF-04449913 • Hematologic cancers • Phase I • PF-04856884 • Solid tumours • Phase II
Best Biotechnology • Aleglitazar • Major CV events and • Phase III Pipeline type 2 diabetes • Ocrelizumab • Progressive and relapsing MS • Phase III • Lebrikizumab • Severe asthma • Regulatory submission expected after 2016 • Bitopertin • Schizophrenia • Phase III
Best Oncology • Trastuzumab-DM1 • HER2 positive breast cancer • Phase III Pipeline • Onartuzumab • Non-squamous, non-small • Phase II & III cell lung cancer • Obinutuzumab • chronic lymphocytic • Phase III leukemia and non-Hodgkin’s lymphoma
CPM *Source: Adapted from Andrew Humphrey’s article Top 10 Pipelines in MedAdNews , January 2013, Volume 32, Number 1.
Canadian Pharmaceutical Marketing l April/May 2013 5