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Index 232 tet 42–3 antidiabetic drugs 219–30 antimalarials 211 AAS see atomic absorption spectroscopy AOs see atomic orbitals Ab peptide 230, 232–5 APL see acute promyelocytic leukemia absorption spectra 16–28 apoferritin 292–3 band assignments 24–8 APP see amyloid precursor protein band intensity/selection rules 19–21, 26–7 area under curve (AUC) 113–14, 157 Beer–Lambert law 17–18 arginine 51 carboplatin 110–11, 114 Arrhenius equation 34–5 cisplatin 75–6 arsenic trioxide (ATO) 290–2 crystal field theory 17–18, 20–8 ascorbic acid 155–6, 157–8 gold compounds 192, 205, 209–10 asparagine 51 group theory 22 aspartic acid 51, 53 Jahn–Teller distortions 18–19, 20 associative mechanism 35–6, 41 oxaliplatin 129 ATO see arsenic trioxide ruthenium anticancer drugs 157, 159–60 atomic absorption spectroscopy (AAS) 66–7, 114 spectroscopic/free ion terms 20–4 atomic orbitals (AOs) 11–16 splitting parameters 24–8 ATP7A/B protein mutations 84, 87, 235, 236 Tanabe–Sugano diagrams 22–6, 27 AUC see area under curve titanium III hexahydrate 17–19 auranofin 193–200, 203–5 vanadium antidiabetic drugs 220, 223–7 aurocyanide 210–11 accelerator mass spectrometry (AMS) 132 aurothioglucose 193–4 acquired immunodeficiency syndrome see HIV/AIDS aurothiosulfate 193–4 acquired resistance 118, 158 activation by reduction hypothesis 155 b-cyclodextrin 270–1 acute promyelocytic leukemia (APL) 290–2 b-sheets 51, 202, 204 adenine 58–9 BBR3464 137, 140–1 Alzheimer disease (AD) 230–5, 257–8 BCM-ESR see blood-circulation monitoring–electron AMD3100 238–42 spin resonance Ames tests 67 Beer–Lambert law 17–18 amino acid structure 50–1 BEOV 219–20, 221–5 ammonium tetrathiomolybdate (TTM) 235–6 bicyclams 238–42 AMS see accelerator mass spectrometryCOPYRIGHTEDbis(acetylaceonato)oxovanadium(IV) MATERIAL 220, 226–9 amyloid beta (Ab) peptide 230, 232–5 bis(4,7-dimethyl-1,10-phenanthroline) amyloid cascade hypothesis 230 sulfatooxovanadium(IV) 228–30 amyloid precursor protein (APP) 230 bis(ethylmaltolato)oxovanadium(IV) 219–20, 221–5 animal studies 67 bis(maltolato)oxovanadium(IV) 220, 221–5 anti-HIV/AIDS drugs 210–11, 238, 242 bis(picolinato)oxovanadium(IV) 220, 226–8 antiarthritic drugs 192–205 BL see Burkitt’s lymphoma antibodies 283, 300–2 bladder cancer 121, 132, 207 Metals in Medicine James C.

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Ep 2569287 B1
(19) TZZ _T (11) EP 2 569 287 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07D 413/04 (2006.01) C07D 239/46 (2006.01) 09.07.2014 Bulletin 2014/28 (86) International application number: (21) Application number: 11731562.2 PCT/US2011/036245 (22) Date of filing: 12.05.2011 (87) International publication number: WO 2011/143425 (17.11.2011 Gazette 2011/46) (54) COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE VERBINDUNGEN ALS HEMMER DER ATR-KINASE COMPOSÉS UTILISABLES EN TANT QU’INHIBITEURS DE LA KINASE ATR (84) Designated Contracting States: • VIRANI, Aniza, Nizarali AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Abingdon GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO Oxfordshire OX144RY (GB) PL PT RO RS SE SI SK SM TR • REAPER, Philip, Michael Abingdon (30) Priority: 12.05.2010 US 333869 P Oxfordshire OX144RY (GB) (43) Date of publication of application: (74) Representative: Coles, Andrea Birgit et al 20.03.2013 Bulletin 2013/12 Kilburn & Strode LLP 20 Red Lion Street (73) Proprietor: Vertex Pharmaceuticals Inc. London WC1R 4PJ (GB) Boston, MA 02210 (US) (56) References cited: (72) Inventors: WO-A1-2010/054398 WO-A1-2010/071837 • CHARRIER, Jean-Damien Abingdon • C. A. HALL-JACKSON: "ATR is a caffeine- Oxfordshire OX144RY (GB) sensitive, DNA-activated protein kinase with a • DURRANT, Steven, John substrate specificity distinct from DNA-PK", Abingdon ONCOGENE, vol. 18, 1999, pages 6707-6713, Oxfordshire OX144RY (GB) XP002665425, cited in the application • KNEGTEL, Ronald, Marcellus Alphonsus Abingdon Oxfordshire OX144RY (GB) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations.
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Modifications to the Harmonized Tariff Schedule of the United States To
U.S. International Trade Commission COMMISSIONERS Shara L. Aranoff, Chairman Daniel R. Pearson, Vice Chairman Deanna Tanner Okun Charlotte R. Lane Irving A. Williamson Dean A. Pinkert Address all communications to Secretary to the Commission United States International Trade Commission Washington, DC 20436 U.S. International Trade Commission Washington, DC 20436 www.usitc.gov Modifications to the Harmonized Tariff Schedule of the United States to Implement the Dominican Republic- Central America-United States Free Trade Agreement With Respect to Costa Rica Publication 4038 December 2008 (This page is intentionally blank) Pursuant to the letter of request from the United States Trade Representative of December 18, 2008, set forth in the Appendix hereto, and pursuant to section 1207(a) of the Omnibus Trade and Competitiveness Act, the Commission is publishing the following modifications to the Harmonized Tariff Schedule of the United States (HTS) to implement the Dominican Republic- Central America-United States Free Trade Agreement, as approved in the Dominican Republic-Central America- United States Free Trade Agreement Implementation Act, with respect to Costa Rica. (This page is intentionally blank) Annex I Effective with respect to goods that are entered, or withdrawn from warehouse for consumption, on or after January 1, 2009, the Harmonized Tariff Schedule of the United States (HTS) is modified as provided herein, with bracketed matter included to assist in the understanding of proclaimed modifications. The following supersedes matter now in the HTS. (1). General note 4 is modified as follows: (a). by deleting from subdivision (a) the following country from the enumeration of independent beneficiary developing countries: Costa Rica (b).
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Cisplatin Induced Hearing Loss in Paediatric Malignancies
CISPLATIN INDUCED HEARING LOSS IN PAEDIATRIC MALIGNANCIES 1 CISPLATIN INDUCED HEARING LOSS IN PAEDIATRIC MALIGNANCIES A DISSERTATION SUBMITTED IN PARTIAL FULFILMENT OF M.S BRANCH IV OTORHINOLARYNGOLOGY EXAMINATION OF THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY TO BE HELD IN APRIL 2016 2 DEPARTMENT OF OTORHINOLARYNGOLOGY CHRISTIAN MEDICAL COLLEGE VELLORE DECLARATION I declare that this dissertation entitled “Cisplatin induced hearing loss in Paediatric malignancies’’ submitted towards fulfilment of the requirements of the Tamil Nadu Dr. M.G.R. Medical University for the MS Branch IV, Otorhinolaryngology examination to be conducted in April 2016, is the bonafide work of Dr. Susana Mathew, postgraduate student in the Department of Otorhinolaryngology, Christian Medical College, Vellore Dr. Susana Mathew Postgraduate Student (M S Otorhinolaryngology ) Register Number: 221314355 Department of Otorhinolaryngology Christian Medical College Vellore. 3 DEPARTMENT OF OTORHINOLARYNGOLOGY CHRISTIAN MEDICAL COLLEGE VELLORE CERTIFICATE This is to certify that the dissertation entitled “Cisplatin induced hearing loss in paediatric malignancies’’ is a bonafide original work of Dr. Susana Mathew, submitted in partial fulfilment of the rules and regulations for the M S Branch IV, Otorhinolaryngology examination of The Tamil Nadu Dr. M.G.R. Medical University to be held in April 2016. Principal Head Of Department Dr. Alfred Job Daniel Dr. John Mathew Christian Medical College Professor and Head, Vellore- 632002 Department of Otorhinolaryngology, India. Christian Medical College, Vellore. 4 DEPARTMENT OF OTORHINOLARYNGOLOGY CHRISTIAN MEDICAL COLLEGE VELLORE CERTIFICATE This is to certify that the dissertation entitled “Cisplatin induced hearing loss in paediatric malignancies’’ is a bonafide original work of Dr. Susana Mathew, submitted in partial fulfilment of the rules and regulations for the M S Branch IV, Otorhinolaryngology examination of The Tamil Nadu Dr.
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The Personalized Medicine Report
THE PERSONALIZED MEDICINE REPORT 2017 · Opportunity, Challenges, and the Future The Personalized Medicine Coalition gratefully acknowledges graduate students at Manchester University in North Manchester, Indiana, and at the University of Florida, who updated the appendix of this report under the guidance of David Kisor, Pharm.D., Director, Pharmacogenomics Education, Manchester University, and Stephan Schmidt, Ph.D., Associate Director, Pharmaceutics, University of Florida. The Coalition also acknowledges the contributions of its many members who offered insights and suggestions for the content in the report. CONTENTS INTRODUCTION 5 THE OPPORTUNITY 7 Benefits 9 Scientific Advancement 17 THE CHALLENGES 27 Regulatory Policy 29 Coverage and Payment Policy 35 Clinical Adoption 39 Health Information Technology 45 THE FUTURE 49 Conclusion 51 REFERENCES 53 APPENDIX 57 Selected Personalized Medicine Drugs and Relevant Biomarkers 57 HISTORICAL PRECEDENT For more than two millennia, medicine has maintained its aspiration of being personalized. In ancient times, Hippocrates combined an assessment of the four humors — blood, phlegm, yellow bile, and black bile — to determine the best course of treatment for each patient. Today, the sequence of the four chemical building blocks that comprise DNA, coupled with telltale proteins in the blood, enable more accurate medical predictions. The Personalized Medicine Report 5 INTRODUCTION When it comes to medicine, one size does not fit all. Treatments that help some patients are ineffective for others (Figure 1),1 and the same medicine may cause side effects in only certain patients. Yet, bound by the constructs of traditional disease, and, at the same time, increase the care delivery models, many of today’s doctors still efficiency of the health care system by improving prescribe therapies based on population averages.
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Synthesis of Platinum(II) Complexes with Some 1-Methylnitropyrazoles and in Vitro Research on Their Cytotoxic Activity
pharmaceuticals Article Synthesis of Platinum(II) Complexes with Some 1-Methylnitropyrazoles and In Vitro Research on Their Cytotoxic Activity Henryk Mastalarz 1,*, Agnieszka Mastalarz 2, Joanna Wietrzyk 3 , Magdalena Milczarek 3 , Andrzej Kochel 2 and Andrzej Regiec 1 1 Department of Organic Chemistry, Faculty of Pharmacy, Wrocław Medical University, 211A Borowska Street, 50-556 Wrocław, Poland; [email protected] 2 Faculty of Chemistry, The University of Wrocław, 14F Joliot-Curie Street, 50-383 Wrocław, Poland; [email protected] (A.M.); [email protected] (A.K.) 3 Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolf Weigl Street, 53-114 Wrocław, Poland; [email protected] (J.W.); [email protected] (M.M.) * Correspondence: [email protected]; Tel.: +48-717840347; Fax: +48-717840341 Received: 6 October 2020; Accepted: 25 November 2020; Published: 28 November 2020 Abstract: A series of eight novel platinum(II) complexes were synthesized by the reaction of the appropriate 1-methylnitropyrazole derivatives with K2PtCl4 and characterized by elemental analysis, ESI MS spectrometry, 1H NMR, 195Pt NMR, IR and far IR spectroscopy. Thermal isomerization of cis-dichloridobis(1-methyl-4-nitropyrazole)platinum(II) 1 to trans-dichloridobis(1-methyl-4-nitropyrazole)platinum(II) 2 has been presented, and the structure of the compound 2 has been confirmed by X-ray diffraction method. Cytotoxicity of the investigated compounds was examined in vitro on three human cancer cell lines (MCF-7 breast, ES-2 ovarian and A-549 lung adenocarcinomas) and their logP was measured using a shake-flask method.
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Immunoglobulin G Mediates Chemoresistance to Oxaliplatin in Colon Cancer Cells By
Universitätsmedizin Rostock Abteilung für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie, Universitätsmedizin AG Molekulare Onkologie und Immuntherapie Supervisor: PD. Dr. Michael Linnebacher Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway Inauguraldissertation thesis to obtain the academic degree Doctor of medicine (Dr. med.) of the University of Rostock Submitted by Yuru Shang Born on 04/03/1988, Zibo, China Rostock, September, 2019 I https://doi.org/10.18453/rosdok_id00003037 Reviewers Reviewer#1 PD. Dr. rer. nat. Dietmar Zechner, Universitätsmedizin Rostock, Rudolf-Zenker-Institut für Experimentelle Chirurgie Reviewer#2 PD. Dr. med. Armin Wiegering, Universitätsklinikum Würzburg, Klinik für Allgemein-, Viszeral- , Transplantations-, Gefäß- und Kinder-chirurgie Reviewer#3 PD Dr. rer. nat. Michael Linnebacher, Universitätsmedizin Rostock, Abteilung für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie Year of submission: 2019 Year of oral defense: 2021 II Content Abbreviations .............................................................................................................................. VI Abstract ....................................................................................................................................... VII 1. Introduction ........................................................................................................................ 1 1.1 Colon cancer ...........................................................................................................
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Ep 3067054 A1
(19) TZZ¥ZZ_T (11) EP 3 067 054 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 14.09.2016 Bulletin 2016/37 A61K 31/505 (2006.01) A61K 31/55 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) (21) Application number: 16156278.0 (22) Date of filing: 10.09.2008 (84) Designated Contracting States: • MIKULE, Keith AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Cambridge, MA Massachusetts 02139 (US) HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT • LI, Youzhi RO SE SI SK TR Westwood, MA 02090 (US) (30) Priority: 10.09.2007 US 971144 P (74) Representative: Finnie, Isobel Lara 13.12.2007 US 13372 Haseltine Lake LLP Lincoln House, 5th Floor (62) Document number(s) of the earlier application(s) in 300 High Holborn accordance with Art. 76 EPC: London WC1V 7JH (GB) 08830633.7 / 2 200 431 Remarks: (71) Applicant: Boston Biomedical, Inc. This application was filed on 18-02-2016 as a Cambridge, MA 02139 (US) divisional application to the application mentioned under INID code 62. (72) Inventors: • LI, Chiang, Jia Cambridge, MA Massachusetts 02141 (US) (54) NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT (57) The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer. EP 3 067 054 A1 Printed by Jouve, 75001 PARIS (FR) EP 3 067 054 A1 Description REFERENCE TO RELATED APPLICATIONS 5 [0001] This application claims priority to and the benefit of U.S.
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Com(2006)616/F1
DE DE DE ANHANG I LISTE DER INTERNATIONALEN FREINAMEN (INN), DIE DER LISTE DER PHARMAZEUTISCHEN STOFFE, FÜR DIE ZOLLFREIHEIT GILT, IN ANHANG 3 DER VERORDNUNG (EG) Nr. 1719/2005 DER KOMMISSION HINZUZUFÜGEN SIND [Hinweis: 1719/2005 wird im Oktober durch ****/2006 ersetzt] Kenn- KN-Code CAS RN Bezeichnung nr. 696 2842 90 80 12539-23-0 “vangatalcit” 572 2843 90 90 129580-63-8 “satraplatin” 413 2843 90 90 141977-79-9 “miriplatin” 223 2843 90 90 146665-77-2 “eptaplatin” 682 2843 90 90 172903-00-3 “triplatin tetranitrate” 504 2843 90 90 181630-15-9 “picoplatin” 807 2843 90 90 274679-00-4 “padoporfin” 629 2844 40 30 131608-78-1 “technetium (99mTc) nitridocade” 628 2844 40 30 225239-31-6 “technetium (99mTc) fanolesomab” “yttrium (90Y) tacatuzumab tetraxetan” 711 2844 40 30 476413-07-7 “(yttrium (90Y) tacatuzumab”) 738 2845 90 10 474641-19-5 “deutolperisone” 283 2846 90 00 193901-90-5 Gadofosveset 284 2846 90 00 227622-74-4 “gadomelitol” 281 2846 90 00 280776-87-6 “gadocoletic acid” 282 2846 90 00 544697-52-1 “gadodenterate” 761 2903 39 90 354-92-7 “perflisobutane” 497 2903 39 90 355-25-9 “perflubutane” 495 2903 39 90 355-42-0 “perflexane” 498 2903 39 90 76-19-7 “perflutren” DE 1 DE 496 2903 47 00 307-43-7 “perflubrodec” 328 2906 19 00 163217-09-2 “inecalcitol” 727 2906 19 00 524067-21-8 “becocalcidiol” 21 2907 29 00 57-91-0 Alfatradiol 464 2909 49 90 128607-22-7 “ospemifene” 66 2909 49 90 302904-82-1 “atocalcitol” 270 2909 49 90 341524-89-8 “fispemifene” 592 2909 50 90 3380-30-1 “soneclosan” 335 2914 40 90 158440-71-2 “irofulven” 803 2914 70 00
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Stembook 2018.Pdf
The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
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Metal-Peptide Bioconjugates for Targeted Anti-Cancer Therapy
METAL-PEPTIDE BIOCONJUGATES FOR TARGETED ANTI-CANCER THERAPY Dissertation submitted to the Faculty of Chemistry and Biochemistry at the Ruhr-University Bochum, Germany to obtain the degree Doctor of Natural Sciences presented by Dariusz Śmiłowicz, M. Sc. Bochum, January 2020 This work has been carried out between December 2015 and January 2020 under the supervision of Prof. Dr. Nils Metzler-Nolte at the Chair of Inorganic Chemistry I – Bioinorganic Chemistry at the Faculty of Chemistry and Biochemistry, Ruhr-Universität Bochum. Date of oral examination: 08.05.2020 1st Referee: Prof. Dr. Nils Metzler-Nolte 2nd Referee: Prof. Dr. Gilles Gasser 2 Acknowledgements First of all, I would like to express my sincere gratitude to Prof. Dr. Nils Metzler-Nolte for giving me the opportunity to carry out my Ph.D. thesis under his supervision. In my opinion the most important is to work and learn from intimidating person and outstanding scientist. I was lucky to have both. Nils is a lively, enthusiastic, and energetic person, and is always in a good mood, eager to discuss any issue. This is particularly amazing. Moreover, I am also very grateful to Nils for his scientific advices, knowledge, many insightful discussions and suggestions, and for giving me the freedom to pursue various projects. I would like to gratefully acknowledge Prof. Dr. Gilles Gasser for being the second referee of my thesis. In particular I‘d like to thank Dr. Reece Miller for many scientific and life-related discussions. He belongs to the group of interesting people, which you may be lucky to encounter on your way.
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Association of Sodium Thiosulfate with Risk of Ototoxic Effects from Platinum-Based Chemotherapy a Systematic Review and Meta-Analysis
Original Investigation | Oncology Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy A Systematic Review and Meta-analysis Chih-Hao Chen, MD; Chii-Yuan Huang, MD, PhD; Heng-Yu Haley Lin, MD, MPH; Mao-Che Wang, MD, PhD; Chun-Yu Chang, MD; Yen-Fu Cheng, MD, PhD Abstract Key Points Question Is the use of sodium IMPORTANCE Platinum-induced ototoxic effects are a significant issue because platinum-based thiosulfate associated with decreased chemotherapy is one of the most commonly used therapeutic medications. Sodium thiosulfate (STS) risk of ototoxic effects among patients is considered a potential otoprotectant for the prevention of platinum-induced ototoxic effects that treated with platinum-induced functions by binding the platinum-based agent, but its administration raises concerns regarding the chemotherapy? substantial attenuation of the antineoplastic outcome associated with platinum. Findings In this meta-analysis of 4 OBJECTIVE To evaluate the association between concurrent STS and reduced risk of ototoxic clinical trials, including 3 randomized effects among patients undergoing platinum-based chemotherapy and to evaluate outcomes, clinical trials and 278 patients, sodium including event-free survival, overall survival, and adverse outcomes. thiosulfate (STS) was associated with a decreased risk of ototoxic effects when DATA SOURCES From inception through November 7, 2020, databases, including the Cochrane administered during the course of Library, PubMed, Embase, Web of Science, and Scopus, were searched. platinum-based chemotherapy. Meaning This finding suggests that the STUDY SELECTION Studies enrolling patients with cancer who were undergoing platinum-based prophylactic use of STS should be chemotherapy that compared ototoxic effects development between patients who received STS and considered when platinum-based patients who did not and provided adequate information for meta-analysis were regarded as eligible.
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Complexes As Anticancer Agents and Their Use in Drug Delivery Systems
TECHNISCHE UNIVERSITÄT MÜNCHEN FAKULTÄT FÜR CHEMIE PROFESSUR FÜR MOLEKULARE KATALYSE Beyond Cisplatin: N-Heterocyclic Carbene Gold(I) Complexes as Anticancer Agents and their Use in Drug Delivery Systems JENS OBERKOFLER Vollständiger Abdruck der von der Fakultät für Chemie der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften (Dr. rer. nat.) genehmigten Dissertation. Vorsitzender: Prof. Dr. Tom Nilges Prüfer der Dissertation: 1. Prof. Dr. Fritz E. Kühn 2. apl. Prof. Dr. Wolfgang Eisenreich Die Dissertation wurde am 29.07.2020 bei der Technischen Universität München eingereicht und durch die Fakultät für Chemie am 29.09.2020 angenommen. Die vorliegende Arbeit wurde am Arbeitskreis für Molekulare Katalyse der Technischen Universität München im Zeitraum von August 2017 bis Juli 2020 angefertigt. Mein ganz besonderer Dank gilt meinem Doktorvater Herrn Prof. Dr. Fritz E. Kühn für die unkomplizierte Aufnahme in seine Arbeitsgruppe, für die finanziell sorgenfreie Arbeit in einem äußerst angenehmen Arbeitsumfeld und für die Möglichkeit, mein Forschungsthema frei gestalten und meine Ziele uneingeschränkt verfolgen zu können. Des Weiteren gilt mein besonderer Dank meiner Zweitbetreuerin Frau Prof. Dr. Angela Casini für ihren fachlichen Rat, die vielen guten Ideen und die schöne und fruchtbare Zeit an der Cardiff University. Vielen Dank für die Förderung meiner Interessen und die finanzielle und thematische Unterstützung auf internationalen Konferenzen. I Acknowledgements Ein ganz besonderer Dank geht an Ulla Hifinger. Vielen Dank für Ihre freundliche Art und dass Sie sich immer um alle bürokratischen Angelegenheiten kümmern. Ohne Sie würde die gesamte Arbeitsgruppe im Chaos versinken. Größter Dank gebührt Dr. Robert Reich. Danke, dass du unsere Gruppe zusammenhältst und immer ein offenes Ohr für persönliche und fachliche Probleme hast.
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