Email [email protected] Description Q15583 Wed May 9 17:58:48 BST Date 2012 Unique Job 376ce548d294102d ID

Detailed template

information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

PDB header:transcription Chain: A: PDB Molecule:homeobox protein tgif1; 1 c2lk2A_ Alignment 99.9 94 PDBTitle: solution nmr structure of homeobox domain (171-248) of human homeobox2 protein tgif1, northeast structural genomics consortium target3 hr4411b

PDB header:transcription Chain: A: PDB Molecule:homeobox protein tgif2lx; 2 c2dmnA_ 99.8 62 Alignment PDBTitle: the solution structure of the homeobox domain of human2 homeobox protein tgif2lx

Fold:DNA/RNA-binding 3-helical bundle 3 d1x2na1 Alignment 99.8 49 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 4 d1lfup_ Alignment 99.8 36 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 5 d1pufb_ Alignment 99.8 36 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 6 d1mnmc_ Alignment 99.8 33 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 7 d1du6a_ Alignment 99.8 33 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:dna binding protein Chain: A: PDB Molecule:homeobox protein barh-like 1; 8 c2dmtA_ 99.7 21 Alignment PDBTitle: solution structure of the homeobox domain of homeobox2 protein barh-like 1

Fold:DNA/RNA-binding 3-helical bundle 9 d1le8b_ Alignment 99.7 25 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 10 d1yrnb_ Alignment 99.7 30 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:dna binding protein Chain: A: PDB Molecule:homeobox protein otx2; 11 c2dmsA_ 99.7 21 Alignment PDBTitle: solution structure of the homeobox domain of homeobox2 protein otx2 Fold:DNA/RNA-binding 3-helical bundle 12 d1pufa_ Alignment 99.7 19 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 13 d2r5yb1 Alignment 99.7 38 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:gene regulation/dna Chain: A: PDB Molecule:homeodomain-containing protein; 14 c3a01A_ 99.7 19 Alignment PDBTitle: crystal structure of aristaless and clawless homeodomains bound to dna

PDB header:transcription regulation Chain: A: PDB Molecule:homeobox protein nanog; 15 c2kt0A_ 99.7 23 Alignment PDBTitle: solution structure of human stem cell transcription factor nanog2 homeodomain fragment

Fold:DNA/RNA-binding 3-helical bundle 16 d1ftza_ Alignment 99.7 21 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:dna binding protein Chain: A: PDB Molecule:lim/homeobox protein lhx9; 17 c2dmqA_ 99.7 24 Alignment PDBTitle: solution structure of the homeobox domain of lim/homeobox2 protein lhx9

Fold:DNA/RNA-binding 3-helical bundle 18 d1k61a_ Alignment 99.7 33 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:dna binding protein Chain: A: PDB Molecule:homeobox protein goosecoid; 19 c2dmuA_ 99.7 28 Alignment PDBTitle: solution structure of the homeobox domain of homeobox2 protein goosecoid

PDB header:transcription regulator/dna Chain: K: PDB Molecule:pou domain, class 6, transcription factor 20 c3d1nK_ Alignment 99.7 25 1; PDBTitle: structure of human brn-5 transcription factor in complex2 with corticotrophin-releasing hormone gene promoter

PDB header:transcription Chain: A: PDB Molecule:homeobox protein dlx-5; 21 c2djnA_ not modelled 99.7 26 Alignment PDBTitle: the solution structure of the homeobox domain of human2 homeobox protein dlx-5 Fold:DNA/RNA-binding 3-helical bundle 22 d1vnda_ Alignment not modelled 99.7 29 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:homeobox protein nkx-3.1; 23 c2l9rA_ Alignment not modelled 99.7 22 PDBTitle: solution nmr structure of homeobox domain of homeobox protein nkx-3.12 from homo sapiens, northeast structural genomics consortium target3 hr6470a Fold:DNA/RNA-binding 3-helical bundle 24 d1b8ia_ Alignment not modelled 99.7 20 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 25 d1zq3p1 Alignment not modelled 99.7 27 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 26 d1ahdp_ Alignment not modelled 99.7 20 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 27 d1ftta_ Alignment not modelled 99.7 27 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 28 d2e1oa1 Alignment not modelled 99.7 23 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 29 d1nk3p_ Alignment not modelled 99.7 30 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 3; 30 c2dn0A_ not modelled 99.7 25 Alignment PDBTitle: solution structure of the second homeobox domain of human2 zinc fingers and homeoboxes protein 3 Fold:DNA/RNA-binding 3-helical bundle 31 d1b72a_ Alignment not modelled 99.7 21 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 32 d2craa1 Alignment not modelled 99.7 26 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 33 d2cuea1 Alignment not modelled 99.7 20 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:alpha-fetoprotein enhancer binding 34 c2da3A_ Alignment not modelled 99.7 19 protein; PDBTitle: solution structure of the third homeobox domain of at-2 binding transcription factor 1 (atbf1) Fold:DNA/RNA-binding 3-helical bundle 35 d1fjla_ Alignment not modelled 99.7 27 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription/dna Chain: A: PDB Molecule:pou domain, class 5, transcription factor 36 c3l1pA_ not modelled 99.7 22 Alignment 1; PDBTitle: pou protein:dna complex Fold:DNA/RNA-binding 3-helical bundle 37 d1fjlb_ Alignment not modelled 99.7 28 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 38 d1gt0c1 Alignment not modelled 99.7 19 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:alpha-fetoprotein enhancer binding 39 c2da2A_ Alignment not modelled 99.7 33 protein; PDBTitle: solution structure of the second homeobox domain of at- 2 binding transcription factor 1 (atbf1) PDB header:dna binding protein Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 3; 40 c2da5A_ Alignment not modelled 99.6 20 PDBTitle: solution structure of the second homeobox domain of zinc2 fingers and homeoboxes protein 3 (triple homeobox 13 protein) Fold:DNA/RNA-binding 3-helical bundle 41 d1ztra1 Alignment not modelled 99.6 25 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 42 d9anta_ Alignment not modelled 99.6 20 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 43 d1ig7a_ Alignment not modelled 99.6 28 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 44 d1octc1 Alignment not modelled 99.6 19 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 45 d1ocpa_ Alignment not modelled 99.6 21 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 46 d2hddb_ Alignment not modelled 99.6 29 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:alpha-fetoprotein enhancer binding 47 c2da1A_ Alignment not modelled 99.6 23 protein; PDBTitle: solution structure of the first homeobox domain of at-2 binding transcription factor 1 (atbf1) Fold:DNA/RNA-binding 3-helical bundle 48 d1hdpa_ Alignment not modelled 99.6 22 Superfamily:Homeodomain-like Family:Homeodomain PDB header:dna binding protein Chain: A: PDB Molecule:homeobox expressed in es cells 1; 49 c2k40A_ not modelled 99.6 28 Alignment PDBTitle: nmr structure of hesx-1 homeodomain double mutant r31l/e42l Fold:DNA/RNA-binding 3-helical bundle 50 d1uhsa_ Alignment not modelled 99.6 19 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 51 d1jgga_ Alignment not modelled 99.6 23 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 52 d2ecba1 Alignment not modelled 99.6 13 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 53 d2lfba_ Alignment not modelled 99.6 24 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 54 d2ecca1 Alignment not modelled 99.6 20 Superfamily:Homeodomain-like Family:Homeodomain PDB header:dna binding protein Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 2; 55 c2dmpA_ Alignment not modelled 99.6 20 55 c2dmpA_ not modelled 99.6 20 Alignment PDBTitle: solution structure of the third homeobox domain of zinc2 fingers and homeoboxes protein 2 Fold:DNA/RNA-binding 3-helical bundle 56 d1wh5a_ Alignment not modelled 99.6 13 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 57 d2cufa1 Alignment not modelled 99.6 26 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription factor Chain: A: PDB Molecule:octamer-binding transcription factor 1; 58 c1hf0A_ not modelled 99.6 19 Alignment PDBTitle: crystal structure of the dna-binding domain of oct-1 bound2 to dna as a dimer Fold:DNA/RNA-binding 3-helical bundle 59 d1p7ia_ Alignment not modelled 99.6 32 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 60 d1yz8p1 Alignment not modelled 99.6 25 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:transcription 61 c2vi6F_ Alignment not modelled 99.6 28 Chain: F: PDB Molecule:homeobox protein nanog; PDBTitle: crystal structure of the nanog homeodomain

Fold:DNA/RNA-binding 3-helical bundle 62 d1le8a_ Alignment not modelled 99.6 25 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 63 d1bw5a_ Alignment not modelled 99.6 27 Superfamily:Homeodomain-like Family:Homeodomain

PDB header:gene regulation 64 c3a03A_ Alignment not modelled 99.6 23 Chain: A: PDB Molecule:t-cell leukemia homeobox protein 2; PDBTitle: crystal structure of hox11l1 homeodomain

Fold:DNA/RNA-binding 3-helical bundle 65 d1sana_ Alignment not modelled 99.6 18 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 66 d1du0a_ Alignment not modelled 99.6 27 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 67 d1au7a1 Alignment not modelled 99.6 25 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 68 d1f43a_ Alignment not modelled 99.6 22 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 69 d1mh3a1 Alignment not modelled 99.6 24 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 70 d1e3oc1 Alignment not modelled 99.6 18 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 71 d1p7jb_ Alignment not modelled 99.6 28 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription activator/dna Chain: A: PDB Molecule:hepatocyte nuclear factor 1-beta; 72 c2h8rA_ not modelled 99.6 31 Alignment PDBTitle: hepatocyte nuclear factor 1b bound to dna: mody5 gene2 product Fold:DNA/RNA-binding 3-helical bundle 73 d2hi3a1 Alignment not modelled 99.6 17 Superfamily:Homeodomain-like Family:Homeodomain PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein dkfzp686k21156; 74 c2da4A_ not modelled 99.6 16 Alignment PDBTitle: solution structure of the homeobox domain of the2 hypothetical protein, dkfzp686k21156 PDB header:transcription Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 1; 75 c3narA_ not modelled 99.5 19 Alignment PDBTitle: crystal structure of zhx1 hd4 (zinc-fingers and homeoboxes protein 1,2 homeodomain 4) PDB header:dna binding protein Chain: A: PDB Molecule:zinc finger homeobox protein 1b; 76 c2da7A_ not modelled 99.5 23 Alignment PDBTitle: solution structure of the homeobox domain of zinc finger2 homeobox protein 1b (smad interacting protein 1) PDB header:transcription/dna Chain: B: PDB Molecule:hepatocyte nuclear factor 1-alpha; 77 c1ic8B_ not modelled 99.5 28 Alignment PDBTitle: hepatocyte nuclear factor 1a bound to dna : mody3 gene2 product PDB header:transcription Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 2; 78 c3nauA_ not modelled 99.5 23 Alignment PDBTitle: crystal structure of zhx2 hd2 (zinc-fingers and homeoboxes protein 2,2 homeodomain 2) PDB header:transcription/dna 79 c1au7B_ Alignment not modelled 99.5 24 Chain: B: PDB Molecule:protein pit-1; PDBTitle: pit-1 mutant/dna complex

PDB header:transcription 80 c1s7eA_ Alignment 99.5 21 Chain: A: PDB Molecule:hepatocyte nuclear factor 6; PDBTitle: solution structure of hnf-6

Fold:DNA/RNA-binding 3-helical bundle 81 d1s7ea1 Alignment not modelled 99.5 31 Superfamily:Homeodomain-like Alignment Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 82 d1akha_ Alignment not modelled 99.5 27 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 83 d2cqxa1 Alignment not modelled 99.5 22 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription/dna Chain: C: PDB Molecule:pou domain, class 3, transcription factor 84 c2xsdC_ Alignment not modelled 99.5 19 1; PDBTitle: crystal structure of the dimeric oct-6 (pou3f1) pou domain2 bound to palindromic more dna Fold:DNA/RNA-binding 3-helical bundle 85 d1o4xa1 Alignment not modelled 99.5 17 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 86 d1x2ma1 Alignment not modelled 99.5 22 Superfamily:Homeodomain-like Family:Homeodomain PDB header:transcription Chain: A: PDB Molecule:transcription factor 8; 87 c2e19A_ not modelled 99.5 18 Alignment PDBTitle: solution structure of the homeobox domain from human nil-2-2 a zinc finger protein, transcription factor 8 Fold:DNA/RNA-binding 3-helical bundle 88 d1lfba_ Alignment not modelled 99.4 28 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 89 d2p81a1 Alignment not modelled 99.4 29 Superfamily:Homeodomain-like Family:Homeodomain PDB header:membrane protein Chain: A: PDB Molecule:penetratin conjugated gas (374-394) 90 c2nzzA_ Alignment not modelled 97.1 31 peptide; PDBTitle: nmr structure analysis of the penetratin conjugated gas2 (374-394) peptide PDB header:sugar binding, dna binding protein Chain: A: PDB Molecule:maltose binding-a1 homeodomain protein 91 c1mh3A_ Alignment not modelled 97.1 29 chimera; PDBTitle: maltose binding-a1 homeodomain protein chimera, crystal2 form i Fold:DNA/RNA-binding 3-helical bundle 92 d1wi3a_ Alignment not modelled 95.2 29 Superfamily:Homeodomain-like Family:Homeodomain

Fold:DNA/RNA-binding 3-helical bundle 93 d1wh7a_ Alignment not modelled 94.9 17 Superfamily:Homeodomain-like Family:Homeodomain PDB header:rna binding protein Chain: A: PDB Molecule:rna polymerase sigma-h factor; 94 c3mzyA_ not modelled 86.0 6 Alignment PDBTitle: the crystal structure of the rna polymerase sigma-h factor from2 fusobacterium nucleatum to 2.5a PDB header:dna binding protein Chain: A: PDB Molecule:cg11849-pa; 95 c2elhA_ not modelled 84.3 16 Alignment PDBTitle: solution structure of the cenp-b n-terminal dna-binding2 domain of fruit fly distal antenna cg11849-pa PDB header:transcription Chain: A: PDB Molecule:rna polymerase sigma-e factor; 96 c1or7A_ not modelled 83.3 10 Alignment PDBTitle: crystal structure of escherichia coli sigmae with the cytoplasmic2 domain of its anti-sigma rsea PDB header:transcription Chain: A: PDB Molecule:homeobox and leucine zipper protein 97 c2ys9A_ Alignment not modelled 82.0 30 homez; PDBTitle: structure of the third homeodomain from the human homeobox2 and leucine zipper protein, homez Fold:DNA/RNA-binding 3-helical bundle Superfamily:Sigma3 and sigma4 domains of RNA polymerase 98 d1rp3a2 not modelled 76.5 17 Alignment sigma factors Family:Sigma4 domain PDB header:transcription/dna 99 c3bdnB_ Alignment not modelled 74.9 14 Chain: B: PDB Molecule:lambda repressor; PDBTitle: crystal structure of the lambda repressor Fold:DNA/RNA-binding 3-helical bundle Superfamily:Sigma3 and sigma4 domains of RNA polymerase 100 d1or7a1 not modelled 74.5 9 Alignment sigma factors Family:Sigma4 domain Fold:DNA/RNA-binding 3-helical bundle Superfamily:Sigma3 and sigma4 domains of RNA polymerase 101 d1smyf2 not modelled 74.1 13 Alignment sigma factors Family:Sigma4 domain Fold:DNA/RNA-binding 3-helical bundle 102 d1bw6a_ Alignment not modelled 72.3 18 Superfamily:Homeodomain-like Family:Centromere-binding PDB header:signaling protein Chain: A: PDB Molecule:phyr sigma-like domain; 103 c2lfwA_ not modelled 71.1 11 Alignment PDBTitle: nmr structure of the phyrsl-nepr complex from sphingomonas sp. fr1 Fold:lambda repressor-like DNA-binding domains 104 d1rioa_ Alignment not modelled 71.1 10 Superfamily:lambda repressor-like DNA-binding domains Family:Phage repressors PDB header:ca-binding protein Chain: A: PDB Molecule:calmodulin, putative; 105 c2ktgA_ Alignment not modelled 69.9 8 PDBTitle: calmodulin like protein from entamoeba histolytica: solution structure2 and calcium binding properties of a partially folded protein PDB header:transcription Chain: A: PDB Molecule:probable rna polymerase sigma-c factor; 106 c2o8xA_ not modelled 68.8 19 Alignment PDBTitle: crystal structure of the "-35 element" promoter recognition domain of2 mycobacterium tuberculosis sigc PDB header:transcription/dna Chain: D: PDB Molecule:transcriptional activator protein trar; 107 c1h0mD_ not modelled 66.3 12 Alignment PDBTitle: three-dimensional structure of the quorum sensing protein2 trar bound to its autoinducer and to its target dna PDB header:transcription Chain: G: PDB Molecule:rna polymerase sigma factor sigma-28 108 c1rp3G_ Alignment not modelled 65.3 16 (flia); PDBTitle: cocrystal structure of the flagellar sigma/anti-sigma2 complex, sigma-28/flgm Fold:lambda repressor-like DNA-binding domains 109 d1llib_ Alignment not modelled 64.7 9 Superfamily:lambda repressor-like DNA-binding domains Family:Phage repressors

Fold:DNA/RNA-binding 3-helical bundle 110 d1hlva1 Alignment not modelled 64.5 15 Superfamily:Homeodomain-like Family:Centromere-binding PDB header:transcription Chain: A: PDB Molecule:rpoe, ecf sige; 111 c2q1zA_ not modelled 63.9 25 Alignment PDBTitle: crystal structure of rhodobacter sphaeroides sige in complex with the2 anti-sigma chrr PDB header:transcription/membrane protein Chain: A: PDB Molecule:rna polymerase sigma factor; 112 c3hugA_ Alignment not modelled 63.7 12 PDBTitle: crystal structure of mycobacterium tuberculosis anti- sigma factor rsla2 in complex with -35 promoter binding domain of sigl Fold:EF Hand-like 113 d1g8ia_ Alignment not modelled 63.5 18 Superfamily:EF-hand Family:Calmodulin-like

Fold:EF Hand-like 114 d1avsa_ Alignment not modelled 63.2 10 Superfamily:EF-hand Family:Calmodulin-like PDB header:transcription regulator/protein binding Chain: A: PDB Molecule:response regulator; 115 c3t0yA_ not modelled 63.1 11 Alignment PDBTitle: structure of the phyr anti-anti-sigma domain bound to the anti-sigma2 factor, nepr PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ras and ef-hand domain-containing 116 c2pmyB_ not modelled 62.9 16 Alignment protein; PDBTitle: ef-hand domain of human rasef Fold:DNA/RNA-binding 3-helical bundle Superfamily:Sigma3 and sigma4 domains of RNA polymerase 117 d1xsva_ not modelled 61.2 7 Alignment sigma factors Family:YlxM/p13-like PDB header:transcription Chain: B: PDB Molecule:quorum-sensing control repressor; 118 c3sztB_ not modelled 57.6 20 Alignment PDBTitle: quorum sensing control repressor, qscr, bound to n-3- oxo-dodecanoyl-l-2 homoserine lactone Fold:EF Hand-like 119 d1sw8a_ Alignment not modelled 54.8 6 Superfamily:EF-hand Family:Calmodulin-like PDB header:transcription Chain: C: PDB Molecule:cvir transcriptional regulator; 120 c3qp5C_ not modelled 53.3 20 Alignment PDBTitle: crystal structure of cvir bound to antagonist chlorolactone (cl)