For Aldicarb Reregistration Eligibility Decision (RED) Document for Aldicarb

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For Aldicarb Reregistration Eligibility Decision (RED) Document for Aldicarb United States Prevention, Pesticides EPA Environmental Protection and Toxic Substances September 2007 Agency (7508P) Reregistration Eligibility Decision for Aldicarb Reregistration Eligibility Decision (RED) Document for Aldicarb List A Case Number 0140 Approved by: Date: Steven Bradbury, Ph.D. Director Special Review and Reregistration Division Page 2 of 191 Table of Contents Aldicarb Reregistration Eligibility Decision Team ........................................................................ 5 Glossary of Terms and Abbreviations ............................................................................................ 6 Abstract........................................................................................................................................... 8 I. Introduction ................................................................................................................................. 9 II. Chemical Overview.................................................................................................................. 11 A. Chemical Identity..................................................................................................................11 B. Regulatory History ................................................................................................................12 C. Use and Usage Profile...........................................................................................................12 D. Tolerances .............................................................................................................................13 III. Aldicarb Human Health and Environmental Fate and Effects Risk Assessments.................. 14 A. Human Health .......................................................................................................................14 B. Environmental Fate and Effects ............................................................................................14 IV. Risk Management, Reregistration Decision, and Tolerance Reassessment Decisions .......... 18 A. Determination of Reregistration Eligibility ..........................................................................18 B. Public Comments and Responses..........................................................................................18 C. Regulatory Position...............................................................................................................19 1. Food Quality Protection Act Findings .............................................................................. 19 a. "Risk Cup" Determination ............................................................................................ 19 b. Determination of Safety to U.S. Population (Including Infants and Children) ............ 19 c. Endocrine Disruptor Effects.......................................................................................... 19 d. Cumulative Risks.......................................................................................................... 20 2. Tolerance Summary.......................................................................................................... 20 D. Regulatory Rationale.............................................................................................................22 1. Human Health Risk Management and Mitigation ............................................................ 22 a. Dietary Risk Mitigation (Food and Drinking Water).................................................... 22 b. Aggregate Risk Mitigation............................................................................................ 23 c. Occupational Risk Mitigation ....................................................................................... 23 2. Ecological Risk Management and Mitigation................................................................... 23 a. Terrestrial and Aquatic Organisms ............................................................................... 23 3. Mitigation Summary and Crop-Specific Analyses ........................................................... 24 Citrus................................................................................................................................. 25 Cotton................................................................................................................................ 27 Dry Bean ........................................................................................................................... 30 Peanut................................................................................................................................ 31 Potato ................................................................................................................................ 34 Soybean............................................................................................................................. 36 Sugar Beet......................................................................................................................... 37 Sweet Potato...................................................................................................................... 40 4. Other Labeling Requirements........................................................................................... 41 5. Threatened and Endangered Species Considerations ....................................................... 41 V. What Registrants Need to Do................................................................................................... 43 A. Manufacturing-Use Products ................................................................................................43 1. Additional Generic Data Requirements............................................................................ 43 2. Labeling for Manufacturing-Use Products ....................................................................... 43 Page 3 of 191 B. End-Use Products..................................................................................................................44 1. Additional Product-Specific Data Requirements.............................................................. 44 2. Labeling for End-Use Products......................................................................................... 44 Appendix A. Aldicarb Uses and Use-Patterns Eligible for Reregistration................................58 Appendix B. Table of Generic Data Requirements and Studies Used to Make the Reregistration Decision..............................................................................................................68 Appendix C. Technical Support Documents .............................................................................75 Appendix D. Citations Considered to be Part of the Database Supporting the Reregistration Decision (Bibliography).............................................................................................................77 Appendix E. Generic Data Call-In (GDCI) .............................................................................183 Appendix F. Product-Specific Data Call-In (PDCI)................................................................184 Appendix G. EPA’s Batching of Aldicarb Products for Meeting Data Requirements for Reregistration...........................................................................................................................185 Appendix H. List of Available Related Documents and Electronically Available Forms ......187 Page 4 of 191 Aldicarb Reregistration Eligibility Decision Team EPA Office of Pesticide Programs Special Review and Reregistration Division Sherrie Kinard Anne Overstreet Robert McNally Health Effects Division Jeff Dawson Felicia Fort Michael Metzger Linda Taylor Environmental Fate and Effects Division Jonathan Angier Tom Bailey Jeanette Martinez Dana Spatz Biological and Economic Analysis Division Derek Berwald Angel Chiri Colwell Cook Arnet Jones Monisha Kaul Timothy Kiely Istanbul Yusuf Nicole Zinn Registration Division Joanne Edwards John Hebert Page 5 of 191 Glossary of Terms and Abbreviations AGDCI Agricultural Data Call-In ai Active Ingredient aPAD Acute Population Adjusted Dose BCF Bioconcentration Factor CFR Code of Federal Regulations cPAD Chronic Population Adjusted Dose CSF Confidential Statement of Formulation CSFII USDA Continuing Surveys for Food Intake by Individuals DCI Data Call-In DEEM Dietary Exposure Evaluation Model DFR Dislodgeable Foliar Residue DNT Developmental Neurotoxicity EC Emulsifiable Concentrate Formulation EDWC Estimated Drinking Water Concentration EEC Estimated Environmental Concentration EPA Environmental Protection Agency EUP End-Use Product FDA Food and Drug Administration FIFRA Federal Insecticide, Fungicide, and Rodenticide Act FFDCA Federal Food, Drug, and Cosmetic Act FQPA Food Quality Protection Act GLN Guideline Number IR Index Reservoir LC50 Median Lethal Concentration. A statistically derived concentration of a substance that can be expected to cause death in 50% of test animals. It is usually expressed as the weight of a substance per weight or volume of water, air, or feed, e.g., mg/l, mg/kg, or ppm. LD50 Median Lethal Dose. A statistically derived single dose that can be expected to cause death in 50% of the test animals when administered by the route indicated (oral, dermal, inhalation). It is expressed as a weight of substance per unit weight of animal, e.g., mg/kg. LOC Level of Concern LOAEL Lowest Observed Adverse Effect Level MATC Maximum
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