DOCSLIB.ORG

Research Council (MRC)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

The Medical Research Council (MRC) The Medical Research Council (MRC) is a national organisation funded by the UK taxpayer. It promotes research into all areas of medical and related science, with the aims of maintaining and improving public health and of contributing to national wealth and quality of life.The research it supports and the scientists it trains meet the needs of the health services, the pharmaceutical and other health- related industries and the academic world. MRC has funded work, which has led to some of the most significant discoveries and achievements of 20th century medicine, for example the clinical use of penicillin – the first antibiotic –, deciphering the structure of DNA, and establishing the link between smoking and cancer. The MRC has three major MRC Institutes: the National Institute for Medical Research (NIMR, Mill Hill, London); the Laboratory of Molecular Biology; (LMB, Cambridge), and the Clinical Sciences Centre (CSC, Hammersmith Hospital, London). In addition, there are 32 smaller MRC Units, an MRC Health Services Research Collaboration and three grant-funded Centres, most of which are attached to higher education institutions and hospitals throughout the UK.The MRC also has laboratories overseas, in The Gambia and Uganda.About half of the MRC’s expenditure of £345 million in 1999/2000 was invested in MRC establishments, where it employs its own research staff.The remaining half funded grant support and training awards to individuals and teams in universities and medical schools. In 1999/2000, the three main MRC Institutes; spent a total of £52 million between them, while spending on Units amounted to £72 million. MRC Centres and Units, are established, depending on which type of organisation is most appropriate to the scientific needs and their host setting, to boost research in specific areas or give impetus to research teams beyond the scale of their host institution’s usual research activities. Many of them provide an international focus of expertise in particular areas of science. Some establishments are jointly funded with BBSRC.These are the Neuropathogenesis Unit, the Oxford Centre for Molecular Sciences and the Jenner Institute for Vaccine Research. In 2000 the MRC awarded new centre grants for: Inflammation Research (Edinburgh), Social, Genetic and Developmental Psychiatry (Institute of Psychiatry, London), and Developmental Neurobiology (King’s College, London). Interdisciplinary research collaborations have been formed with BBSRC and EPSRC in imaging, nanotechnology and tissue engineering. 37 MRC Clinical Sciences Centre (CSC) CSC forms the centrepiece of the MRC’s clinical research initiative, which is aimed at integrating basic biological science with clinical research. It is now the second largest of the MRC’s research establishments and has brought together a number of pre-existing MRC Units, together with research groups and a number of new research teams. The CSC is located at the Hammersmith Hospital in West London, the major clinical research campus of Imperial College School of Medicine (ICSM), and has formed a close partnership with both ICSM and the Hammersmith Hospitals NHS Trust (HHT).A new Clinical Research Fellowships scheme has been established jointly with ICSM to promote excellence in research training in academic medicine. The CSC has strengths in two of the most important and far-reaching approaches to studying biological mechanisms, genetics and cell biology, and in vivo imaging and spectroscopy.The CSC undertakes innovative, multidisciplinary research, which underpins and advances our understanding of human health and disease and fosters links between basic science and clinical medicine. By bridging these disciplines, CSC aims to build an integrated understanding of the molecular and cellular basis of disease, and so speed the clinical delivery of improved detection, prevention and treatment of disease. Director: Contact: Professor Chris Higgins PhD FRSE Mags Clappison MRC Clinical Sciences Centre Tel: 020 8383 8769 Imperial College School of Medicine Hammersmith Campus Website: Du Cane Road www.csc.mrc.ac.uk London W12 0NN Staff: Science and Research Project Expenditure 1999-2000: Support 174 £8 million Management, administration and policy 21 Infrastructure 4 Technical services 49 38 MRC National Institute for Medical Research (NIMR) The MRC National Institute for Medical Research is the Council’s largest research establishment.The emphasis is on fundamental non-clinical studies, although staff at the Institute collaborate in clinical research programmes in the UK and the tropics. NIMR research is grouped into four major areas: Neurosciences, which analyses the molecular basis of brain and nervous system function; Structural Biology, which studies the structure, function and interactions between a range of biologically active and medically important molecules; Genes & Development, which investigates the molecular signals that control development from embryo to adult; and Infections and Immunity, which aims to understand immune system development, the molecular basis of bacterial, viral and parasitic infections, and investigate how infections and vaccinations produce immunity. Although the MRC is the single largest source of research funding, the Institute also attracts support from a wide range of different agencies, including medical research charities, international sources, particularly the EU, and from industry.The World Influenza Centre based in NIMR’s Division of Virology and the Division of Mycobacterial Research are recognised as WHO Collaborating Centres for reference on influenza and M.leprae. Director: Contact: Sir John Skehel PhD FRS Mark Franklin National Institute for Medical Research Tel: 020 8959 3666 The Ridgeway Mill Hill Website: London www.nimr.mrc.ac.uk NW7 1AA Staff: Expenditure 2000-2001: 400 scientists £25 million 150 support 39 MRC Laboratory of Molecular Biology (LMB) LMB aims to understand the basic processes of life.The Laboratory has two major goals. Firstly to interpret biological phenomena at the molecular level through a wide range of studies on the structure of proteins, nucleic acids, membranes, organelles and viruses. Secondly to undertake research on the mechanisms and control of gene expression and the three-dimensional organisation of cells.A further aim is to understand pathological conditions in humans.This largely fundamental research uses a variety of biological systems, depending on which is most appropriate to the phenomena under investigation and the experimental approach being used.The analytical methods employed include X-ray crystallography, NMR, electron microscopy and computational and theoretical studies, allied to biochemical and molecular biological approaches. LMB has four research divisions, structural studies, protein and nucleic acid chemistry, cell biology and neurobiology, but scientific collaboration across these boundaries is extensive, and fluctuating associations between individual staff members are used to tackle problems of common interest.The cross-fertilisation between areas is illustrated by the importance of myelomas and leukaemias for research in molecular immunology and by the way in which recent advances in understanding neurodegenerative diseases, cancer and AIDS are revolutionising diagnosis. Director: Contact: Dr Richard Henderson PhD FRS Jennifer Cornwell Laboratory of Molecular Biology Tel: 020 7670 5478 Hills Road Cambridge Website: CB2 2QH www.mrc-lmb.cam.ac.uk Expenditure 1999-2000: Staff: £17 million 276 scientists 142 research, technical and support. 40 Medical Research Council Units and Centres Anatomical Neuropharmacology Unit The aims of this unit are to elucidate neuronal networks by analysis of the properties, synaptic connections and molecular components of identified neurones in the brain, with particular reference to behaviour and to disease. University Department of Pharmacology Mansfield Road Oxford OX1 3TH Tel:01865-271 865 Fax: 01865-271 647 http://mrcanu.pharm.ox.ac.uk Biochemical and Clinical Magnetic Resonance Unit The unit is investigating the biochemical basis of human diseases in an integrated programme ranging from cellular studies to clinical problems. Special emphasis is placed on the development and application of magnetic resonance spectroscopy for the observation of metabolic processes in cells, living tissues and man.The British Heart Foundation NMR Research Group is associated with this unit. MRC Centre, Oxford Magnetic Resonance Spectroscopy John Radcliffe Hospital Headington Oxford OX3 9DU Tel:01865-221 868 Fax: 01865-221 112 www.bioch.ox.ac.uk Biostatistics Unit The unit is concerned with the development and application of statistical methods in medicine and biology.This includes research into the epidemiology and aetiology of disease, the development of models of the natural history of disease, the design and analysis of trials of preventive measures or of therapeutic or prophylactic agents and the evaluation of medical technology, and the development of mathematical- statistical techniques. Much of the work of the unit is performed in collaboration with other Council units and other scientific workers. Institute of Public Health University Forvie Site Robinson Way Cambridge CB2 2SR Unit secretary:Tel:01223-330 366 Fax: 01223-330 388 www.mrc-bsu.cam.ac.uk 41 BBSRC and MRC Neuropathogenesis Unit The unit studies diseases of the nervous system caused by unconventional agents. The pathogenesis of these conditions will be compared with other
Recommended publications
  • Robert Patrick (Bob) Goldstein James L

    Robert Patrick (Bob) Goldstein James L

    Robert Patrick (Bob) Goldstein James L. Peacock III Distinguished Professor Biology Department University of North Carolina at Chapel Hill Chapel Hill, NC 27599-3280 USA email bobg @ unc.edu, phone 919 843-8575 http://www.bio.unc.edu/faculty/goldstein/ PROFESSIONAL EXPERIENCE 1999-current Faculty, UNC Chapel Hill Biology Department and Member, Lineberger Comprehensive Cancer Center EDUCATION PhD: University of Texas at Austin, 1992, Zoology BS: Union College, Schenectady, New York, 1988, Biology RESEARCH TRAINING 1996-1999 Miller Institute Postdoctoral Research Fellow, University of California, Berkeley, Department of Molecular and Cell Biology, Laboratory of Dr. David Weisblat. 1992-1996 Postdoctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge, England. Laboratory of Dr. John White 1992-1993. Independent 1993-1996. 1988-1992 PhD student, University of Texas at Austin. Laboratory of Dr. Gary Freeman. AWARDS 2018 Chapman Family Teaching Award, UNC Chapel Hill 2016 James L. Peacock III Distinguished Professor 2008 Elected Life Member of Clare Hall, Cambridge University 2007 Guggenheim Fellow 2007 Visiting Fellow, Clare Hall, Cambridge University 2005 Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement by Young Faculty at UNC Chapel Hill 2000-2004 Pew Scholar 2000-2002 March of Dimes Basil O'Connor Scholar 1996-1998 Miller Institute Research Fellow, University of California, Berkeley 1996 Medical Research Council Postdoctoral Fellow, Cambridge, England 1995 Development Traveling Fellow 1994-1996 Human Frontiers
  • Tick Saliva and Its Role in Pathogen Transmission

    Tick Saliva and Its Role in Pathogen Transmission

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by NERC Open Research Archive lyme borreliosis Wien Klin Wochenschr https://doi.org/10.1007/s00508-019-1500-y Tick saliva and its role in pathogen transmission Patricia A. Nuttall Received: 22 February 2019 / Accepted: 9 April 2019 © The Author(s) 2019 Summary Tick saliva is a complex mixture of peptidic cle of egg, larva, nymph, and adult (female or male). and non-peptidic molecules that aid engorgement. Each postembryonic stage generally requires a blood The composition of tick saliva changes as feeding meal before moulting to the next stage [2]. During progresses and the tick counters the dynamic host blood-feeding, ticks acquire infections they may sub- response. Ixodid ticks such as Ixodes ricinus,the sequently transmit when feeding again. When this most important tick species in Europe, transmit nu- occurs, ticks act as vectors of potential pathogens of merous pathogens that cause debilitating diseases, humans and other animals [3]. In fact, ticks are be- e.g. Lyme borreliosis and tick-borne encephalitis. lieved to transmit the greatest variety of infectious Tick-borne pathogens are transmitted in tick saliva agents of any blood-feeding vector. Notable diseases during blood feeding; however, saliva is not simply of humans caused by tick-borne pathogens include a medium enabling pathogen transfer. Instead, tick- Lyme borreliosis, tick-borne encephalitis (TBE), tu- borne pathogens exploit saliva-induced modulation laremia, babesiosis, rickettsiosis, and human granu- of host responses to promote their transmission and locytic anaplasmosis; however, tick-borne infectious infection, so-called saliva-assisted transmission (SAT).
  • 80 Stephen Paget Memorial Lecture and Openness Awards Ceremony 5

    80 Stephen Paget Memorial Lecture and Openness Awards Ceremony 5

    80th Stephen Paget Memorial Lecture and Openness Awards Ceremony 5th December 2016 Royal College of Physicians, London #ConcordatOpenness Programme 18:00 Arrival and Refreshments 18:30 Welcome Address 18:40 Openness Awards Internal or sector engagement activity Public engagement activity Media engagement or media stories Website or use of new media Individual award 19:00 80th Paget Lecture by Professor Sir Mark Walport Animal Research – Then and Now 20:00 Drinks Reception 21:30 End The Stephen Paget Memorial Lecture The Stephen Paget Memorial Lecture is a scientific lecture to commemorate the life of Dr Stephen Paget. Stephen Paget (1855 – 1926) was the founder of the Research Defence Society, a forerunner of Understanding Animal Research. He believed passionately that better science and understanding of physiology would lead to better medical treatments. After his death in 1926, he was greatly missed by his medical colleagues and the scientific community. The first Stephen Paget memorial lecture was given in 1927 to commemorate his life and allow leading bio-medical scientists of the day to talk about their research. The Openness Awards The Concordat on Openness launched in May 2014 and has to date brought together 109 organisations in a pledge to be more open and transparent about the use of animals in research. This year the Openness Awards celebrate five recipients that have met the Concordat commitments and encouraged the widespread sharing of best practice. Professor Sir Mark Walport, FRS, FMedSci Sir Mark is the Chief Scientific Adviser to HM Government and Head of the Government Office for Science. Previously, Sir Mark was Director of the Wellcome Trust.
  • Tick-Borne Pathogens and Diseases in Greece

    Tick-Borne Pathogens and Diseases in Greece

    microorganisms Review Tick-Borne Pathogens and Diseases in Greece Artemis Efstratiou 1,†, Gabriele Karanis 2 and Panagiotis Karanis 3,4,* 1 National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan; [email protected] 2 Orthopädische Rehabilitationsklinik, Eisenmoorbad Bad Schmiedeberg Kur GmbH, 06905 Bad Schmiedeberg, Germany; [email protected] 3 Medical Faculty and University Hospital, The University of Cologne, 50923 Cologne, Germany 4 Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi. P.O. Box 24005, Nicosia CY-1700, Cyprus * Correspondence: [email protected] † Current address: Max-Planck Institute for Evolutionary Biology, 24306 Plön, Germany. Abstract: Tick-borne diseases (TBDs) are recognized as a serious and growing public health epidemic in Europe, and are a cause of major losses in livestock production worldwide. This review is an attempt to present a summary of results from studies conducted over the last century until the end of the year 2020 regarding ticks, tick-borne pathogens, and tick-borne diseases in Greece. We provide an overview of the tick species found in Greece, as well as the most important tick-borne pathogens (viruses, bacteria, protozoa) and corresponding diseases in circulation. We also consider prevalence data, as well as geographic and climatic conditions. Knowledge of past and current situations of TBDs, as well as an awareness of (risk) factors affecting future developments will help to find approaches to integrated tick management as part of the ‘One Health Concept’; it will assist in avoiding the possibility of hotspot disease emergencies and intra- and intercontinental transmission.
  • Molecular Microbiology. a New Journal. Edited by Higgins Chris and Schoolnik Gary. Published Bimonthly by Blackwell Scientific P

    Molecular Microbiology. a New Journal. Edited by Higgins Chris and Schoolnik Gary. Published Bimonthly by Blackwell Scientific P

    Book reviews 76 Molecular Microbiology. A new journal. Edited by Erwinia carotovora carotovora, Clostridium perfrin- CHRIS HIGGINS and GARY SCHOOLNIK. Published gens, Acinetobacter calcoaceticus, Streptococcus mu- bimonthly by Blackwell Scientific Publications Ltd, tans, S. pneumoniae, Bacillus circulans, B. sphaericus, Oxford. Vol. 1: three issues in 1987, subsequent B. thuringiensis, Histoplasma capsulatum, a halophilic volumes six issues. Price 1987 £40.00 in UK, £48.00 Archaebacterium, Aspergillus nidulans, Dictyostelium Overseas; 1988 £88.00 and £105.00. ISSN 0950- discoideum and a cyanobacterium (Calothrix). There 382X. are a number of papers from major research groups, This is a handsome new journal, in the now popular and it is obvious that the new journal has got off to a large format (1 Of x 8| inches), which will catch the eye very good start. All those interested in this wide range of the reader scanning the library display shelves, by of microbiological topics will have to keep a close eye its colourful front cover. The paper inside is of good on its current and future numbers. enough quality to give clear half-tone prints and the It is a remarkable fact that we now have the main choice of size of print and type face makes for easy editorial offices of three journals publishing essentially reading. Tables of DNA and amino-acid sequences genetic research located in Scotland - Genetical Re- vary from large and easily read (e.g. vol. 1, page 205) search from Edinburgh, Genes and Development from to very small print (page 175 in the same issue) which the AFRC Institute at Roslin, near Edinburgh, and would give a selective advantage to the short-sighted now Molecular Microbiology edited from the Uni- and those young enough to be able to sex Drosophila versity of Dundee, only 57 miles from Edinburgh.
  • The Production of New Potato Varieties: Technological Advances

    The Production of New Potato Varieties: Technological Advances

    Book reviews 76 Molecular Microbiology. A new journal. Edited by Erwinia carotovora carotovora, Clostridium perfrin- CHRIS HIGGINS and GARY SCHOOLNIK. Published gens, Acinetobacter calcoaceticus, Streptococcus mu- bimonthly by Blackwell Scientific Publications Ltd, tans, S. pneumoniae, Bacillus circulans, B. sphaericus, Oxford. Vol. 1: three issues in 1987, subsequent B. thuringiensis, Histoplasma capsulatum, a halophilic volumes six issues. Price 1987 £40.00 in UK, £48.00 Archaebacterium, Aspergillus nidulans, Dictyostelium Overseas; 1988 £88.00 and £105.00. ISSN 0950- discoideum and a cyanobacterium (Calothrix). There 382X. are a number of papers from major research groups, This is a handsome new journal, in the now popular and it is obvious that the new journal has got off to a large format (1 Of x 8| inches), which will catch the eye very good start. All those interested in this wide range of the reader scanning the library display shelves, by of microbiological topics will have to keep a close eye its colourful front cover. The paper inside is of good on its current and future numbers. enough quality to give clear half-tone prints and the It is a remarkable fact that we now have the main choice of size of print and type face makes for easy editorial offices of three journals publishing essentially reading. Tables of DNA and amino-acid sequences genetic research located in Scotland - Genetical Re- vary from large and easily read (e.g. vol. 1, page 205) search from Edinburgh, Genes and Development from to very small print (page 175 in the same issue) which the AFRC Institute at Roslin, near Edinburgh, and would give a selective advantage to the short-sighted now Molecular Microbiology edited from the Uni- and those young enough to be able to sex Drosophila versity of Dundee, only 57 miles from Edinburgh.
  • Directory 2016/17 the Royal Society of Edinburgh

    Directory 2016/17 the Royal Society of Edinburgh

    cover_cover2013 19/04/2016 16:52 Page 1 The Royal Society of Edinburgh T h e R o Directory 2016/17 y a l S o c i e t y o f E d i n b u r g h D i r e c t o r y 2 0 1 6 / 1 7 Printed in Great Britain by Henry Ling Limited, Dorchester, DT1 1HD ISSN 1476-4334 THE ROYAL SOCIETY OF EDINBURGH DIRECTORY 2016/2017 PUBLISHED BY THE RSE SCOTLAND FOUNDATION ISSN 1476-4334 The Royal Society of Edinburgh 22-26 George Street Edinburgh EH2 2PQ Telephone : 0131 240 5000 Fax : 0131 240 5024 email: [email protected] web: www.royalsoced.org.uk Scottish Charity No. SC 000470 Printed in Great Britain by Henry Ling Limited CONTENTS THE ORIGINS AND DEVELOPMENT OF THE ROYAL SOCIETY OF EDINBURGH .....................................................3 COUNCIL OF THE SOCIETY ..............................................................5 EXECUTIVE COMMITTEE ..................................................................6 THE RSE SCOTLAND FOUNDATION ..................................................7 THE RSE SCOTLAND SCIO ................................................................8 RSE STAFF ........................................................................................9 LAWS OF THE SOCIETY (revised October 2014) ..............................13 STANDING COMMITTEES OF COUNCIL ..........................................27 SECTIONAL COMMITTEES AND THE ELECTORAL PROCESS ............37 DEATHS REPORTED 26 March 2014 - 06 April 2016 .....................................................43 FELLOWS ELECTED March 2015 ...................................................................................45
  • (Soft) Ticks (Acari: Parasitiformes: Argasidae) in Relation to Transmission of Human Pathogens

    (Soft) Ticks (Acari: Parasitiformes: Argasidae) in Relation to Transmission of Human Pathogens

    International Journal of Vaccines and Vaccination Status of Argasid (Soft) Ticks (Acari: Parasitiformes: Argasidae) In Relation To Transmission of Human Pathogens Abstract Review Article Ticks transmit a greater variety of infectious agents than any other arthropod group, Volume 4 Issue 4 - 2017 in fact, these are second only to mosquitoes as carriers of human pathogens. This article concerns to the different ticks as vectors of parasites and their control methods having a major focus on vaccines against pathogens. Typically, argasids do not possess Department of Entomology, Nuclear Institute for Food & a dorsal shield or scutum, their capitulum is less prominent and ventrally instead Agriculture (NIFA), Pakistan anteriorly located, coxae are unarmed (without spurs), and spiracular plates small. A number of genera and species of ticks in the families Argasidae (soft ticks) are of public *Corresponding author: Muhammad Sarwar, Department health importance. Certain species of argasid ticks of the genera Argas, Ornithodoros, of Entomology, Nuclear Institute for Food & Agriculture Carios and Otobius are important in the transmission of many human’s pathogens. (NIFA), Pakistan, Email: Moreover, argasids have multi-host life cycles and two or more nymphal stages each requiring a blood meal from a host. Unlike the ixodid (hard) ticks, which stay attached Received: December 11, 2016 | Published: September 21, to their hosts for up to several days while feeding, most argasids are adapted to feed 2017 rapidly (for about an hour) and then dropping off the host. They transmit a variety of pathogens of medical and veterinary interest, including viruses, bacteria, rickettsiae, helminthes, and protozoans, all of which are able to cause damage to livestock production and human health.
  • Top of the Profs Imperial’S New Professors Centre Pages

    Top of the Profs Imperial’S New Professors Centre Pages

    reporter www.imperial.ac.uk Issue 168 • 11 October 2006 Top of the Profs Imperial’s new professors centre pages BENCH TO BEDSIDE TOP TEN SUCCESS NHS Trusts set to merge Imperial climbs four with Imperial in UK’s places in THES World first Academic Health University Rankings. Sciences Centre. PAGE 3 PAGE 3 Historian gets fired up on the Queen’s Lawn in brief New head for Population Biology Georgina Mace, FRS, has been appointed Professor of Conservation Science and Director of the Natural Environment Research Council’s (NERC) Centre for Population Biology. Professor Mace joins Impe- rial from the Zoological Society of London, where she has been Director of Science since 2000. Her new role will see her leading a large team at Silwood Park Campus working on diverse research projects including biodiversity patterns, ecology and evolution. MRC selects Kennard Deputy Principal of the Faculty of Medicine, Professor Chris Kennard, has been selected for the Council of the Medical Research Council (MRC) by the Science and Innovation Minister, Lord Sainsbury, and will also chair the MRC’s Neuro- science and Mental Health Board. The MRC, which A flaming kettle lit up the Queen’s Lawn this summer when TV science historian Adam Hart-Davis dropped into the College for an afternoon’s filming for his new show,How London Was Built. The renowned science broadcaster watched as Dr Jon Gibbins is publicly funded, aims to improve human health from Mechanical Engineering gave an impressive demonstration of the combustion of coal gas, in the shadow of the Queen’s by supporting research and training scientists to Tower.
  • Tick-Borne Transmission of Murine Gammaherpesvirus 68

    Tick-Borne Transmission of Murine Gammaherpesvirus 68

    ORIGINAL RESEARCH published: 31 October 2017 doi: 10.3389/fcimb.2017.00458 Tick-Borne Transmission of Murine Gammaherpesvirus 68 Valeria Hajnická 1, Marcela Kúdelová 1, Iveta Štibrániová 1, Mirko Slovák 2, Pavlína Bartíková 1, Zuzana Halásová 1, Peter Pancíkˇ 1, Petra Belvoncíkovᡠ1, Michaela Vrbová 3, Viera Holíková 1, Rosemary S. Hails 4 and Patricia A. Nuttall 4, 5* 1 Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia, 2 Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia, 3 Department of Microbiology and Virology, Comenius University, Bratislava, Slovakia, 4 Centre for Ecology and Hydrology, Wallingford, United Kingdom, 5 Department of Zoology, University of Oxford, Oxford, United Kingdom Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. This rodent virus appears to be geographically widespread; however, its natural transmission cycle is unknown. Following detection of MHV68 in field-collected ticks, including isolation of the virus from tick salivary glands and ovaries, we investigated whether MHV68 is a tick-borne virus. Uninfected Ixodes ricinus ticks were shown to acquire the virus by feeding on experimentally infected laboratory mice. The virus survived tick molting, and the molted ticks transmitted the virus to uninfected laboratory mice on which they subsequently fed. MHV68 was isolated from the tick salivary glands, consistent with transmission via tick saliva. The virus survived in ticks without loss of infectivity for at least 120 days, and subsequently was transmitted Edited by: vertically from one tick generation to the next, surviving more than 500 days.
  • What If the Earth Stopped Spinning? 3 Maser to Predict Milky Way's Fate 8

    What If the Earth Stopped Spinning? 3 Maser to Predict Milky Way's Fate 8

    What if the Earth stopped spinning? 3 Maser to predict Milky Way's fate 8 Will we ever glimpse the universe's first stars? 10 When is a group of stars not a galaxy? 12 Telltale chemistry could betray ET 14 Online games reveal players' personalities – to who? 16 Compact 'eyeball' camera stretches to zoom 18 PirateBox lets you share files with anyone close by 20 Spinning seeds inspire single-bladed helicopters 21 VW's diesel hybrid: most efficient car on the planet? 23 Parallel parking is better for pedestrians' health 25 Soft-centred fossils reveal dinosaurs' true colours 27 How the seahorse gained its shapely body 31 Mad cow disease is almost extinct globally 32 Transsexual differences caught on brain scan 35 Kids with low self-control are less successful adults 37 Royal rumpus over King Tutankhamun's ancestry 38 Stretchy DNA shows off its elastic qualities 40 Remember the lessons of past clinical trials abuses 42 Quantum reality: The many meanings of life 44 Ancient puzzle gets new lease of 'geomagical' life 49 Deep meaning in Ramanujan's 'simple' pattern 52 Cancer Drug Aids Regeneration of Spinal Cord After Injuries 54 Dinosaurs Survived Mass Extinction by 700,000 Years, Fossil Find Suggests 56 A Mix of Tiny Gold and Viral Particles, and the DNA Ties That Bind Them 58 How Bacteria Keep Ahead of Vaccines and Antibiotics 60 Warming North Atlantic Water Tied to Heating Arctic 63 Brain 'GPS' Illuminated in Migratory Monarch Butterflies 66 Mass Extinction Linked to Ancient Climate Change, New Details Reveal 68 Modern Humans Reached Arabia
  • Books Catalogue 2021

    Books Catalogue 2021

    CABI new books 2021 www.cabi.org KNOWLEDGE FOR LIFE CABI is not like other publishers CABI is an international not-for-profit organisation that improves people’s lives worldwide by providing information and applying scientific expertise to solve problems in agriculture and the environment. CABI is also a global publisher producing key scientific publications, including world renowned databases, as well as compendia, books, eBooks and full text electronic resources. The profits from CABI’s publishing activities enable us to work with farming communities around the world, supporting them as they battle with poor soil, invasive species and pests and diseases, to improve their livelihoods and help provide food for an ever growing population. CABI is an international intergovernmental organisation and we gratefully acknowledge the core financial support from our member countries (and lead agencies) including the United Kingdom (Department for International Development), China (Chinese Ministry of Agriculture), Australia (Australian Centre for International Agricultural Research), Canada (Agriculture and Agri-Food Canada), The Netherlands (Directorate-General for International Cooperation) and Switzerland (Swiss Agency for Development and Cooperation). To find out more about our development work, visit www.cabi.org/projects Stay in touch! Contact us @CABI_Knowledge Editorial @CABI_News For more information on submitting a proposal or discussing a project, please visit: www.cabi.org/bookshop/authors www.facebook.com/CABI.development Marketing If you have any marketing queries, please email: blog.cabi.org [email protected] Welcome to the CABI Books Catalogue 2021 This catalogue contains our recent and forthcoming monographs, textbooks and practitioner titles across our full range of publishing areas.