STC2 Antibody Cat

STC2 Antibody Cat. No.: 57-642 STC2 Antibody STC2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Mouse HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 273-302 amino acids from the C-terminal region of human STC2. TESTED APPLICATIONS: IHC-P, WB For WB starting dilution is: 1:1000 APPLICATIONS: For IHC-P starting dilution is: 1:10~50 September 25, 2021 1 https://www.prosci-inc.com/stc2-antibody-57-642.html PREDICTED MOLECULAR 33 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: STC2 ALTERNATE NAMES: Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2 ACCESSION NO.: O76061 GENE ID: 8614 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein BACKGROUND: may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. REFERENCES: 1) Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) : 2) Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010) September 25, 2021 2 https://www.prosci-inc.com/stc2-antibody-57-642.html 3) Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009) 4) Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 25, 2021 3 https://www.prosci-inc.com/stc2-antibody-57-642.html.

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BioVendor - Laboratorní medicína a.s. Karásek 1767/1 621 00 Brno-Řečkovice a Mokrá Hora Date of issue: 05.01.2021 PRODUCT DATASHEET Stanniocalcin 2 Human HEK293 Cat. No.: RD172096100 Type: Recombinant protein Size: 0.1 mg Source: HEK293 Species: Human Description Total 289 AA. Mw: 31.9 kDa (calculated). C-Terminal Flag-tag, 12AA (highlighted). The AA sequence is identical to Swiss-Prot- O76061 (STC2, aa 25–302). Other names Stanniocalcin-related protein, STC-related protein, STCRP, STC2 Introduction to the molecule Stanniocalcin 2 (STC2) is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. STC2 may have autocrine or paracrine functions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. STC2 is also known to be involved in the regulation of unfolded protein response in the endoplasmic reticulum (ER), as well as in the regulation of cell proliferation under hypoxic conditions. In addition, a series of recent studies have shown that STC2 is also associated with cancer development. The expression of STC2 is up-regulated in several cancer types, including gastric cancer, neuroblastoma, colon cancer, prostate cancer and breast cancer.
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Bioinformatics Integrated Analysis to Investigate Candidate Biomarkers and Associated Metabolites in Osteosarcoma
Wang et al. Journal of Orthopaedic Surgery and Research (2021) 16:432 https://doi.org/10.1186/s13018-021-02578-0 RESEARCH ARTICLE Open Access Bioinformatics integrated analysis to investigate candidate biomarkers and associated metabolites in osteosarcoma Jun Wang, Mingzhi Gong, Zhenggang Xiong, Yangyang Zhao and Deguo Xing* Abstract Background: This study hoped to explore the potential biomarkers and associated metabolites during osteosarcoma (OS) progression based on bioinformatics integrated analysis. Methods: Gene expression profiles of GSE28424, including 19 human OS cell lines (OS group) and 4 human normal long bone tissue samples (control group), were downloaded. The differentially expressed genes (DEGs) in OS vs. control were investigated. The enrichment investigation was performed based on DEGs, followed by protein–protein interaction network analysis. Then, the feature genes associated with OS were explored, followed by survival analysis to reveal prognostic genes. The qRT-PCR assay was performed to test the expression of these genes. Finally, the OS- associated metabolites and disease-metabolic network were further investigated. Results: Totally, 357 DEGs were revealed between the OS vs. control groups. These DEGs, such as CXCL12, were mainly involved in functions like leukocyte migration. Then, totally, 38 feature genes were explored, of which 8 genes showed significant associations with the survival of patients. High expression of CXCL12, CEBPA, SPARCL1, CAT, TUBA1A, and ALDH1A1 was associated with longer survival time, while high expression of CFLAR and STC2 was associated with poor survival. Finally, a disease-metabolic network was constructed with 25 nodes including two disease-associated metabolites cyclophosphamide and bisphenol A (BPA). BPA showed interactions with multiple prognosis-related genes, such as CXCL12 and STC2.
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CD29 Identifies IFN-Γ–Producing Human CD8+ T Cells with an Increased Cytotoxic Potential
+ CD29 identifies IFN-γ–producing human CD8 T cells with an increased cytotoxic potential Benoît P. Nicoleta,b, Aurélie Guislaina,b, Floris P. J. van Alphenc, Raquel Gomez-Eerlandd, Ton N. M. Schumacherd, Maartje van den Biggelaarc,e, and Monika C. Wolkersa,b,1 aDepartment of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands; bLandsteiner Laboratory, Oncode Institute, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; cDepartment of Research Facilities, Sanquin Research, 1066 CX Amsterdam, The Netherlands; dDivision of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; and eDepartment of Molecular and Cellular Haemostasis, Sanquin Research, 1066 CX Amsterdam, The Netherlands Edited by Anjana Rao, La Jolla Institute for Allergy and Immunology, La Jolla, CA, and approved February 12, 2020 (received for review August 12, 2019) Cytotoxic CD8+ T cells can effectively kill target cells by producing therefore developed a protocol that allowed for efficient iso- cytokines, chemokines, and granzymes. Expression of these effector lation of RNA and protein from fluorescence-activated cell molecules is however highly divergent, and tools that identify and sorting (FACS)-sorted fixed T cells after intracellular cytokine + preselect CD8 T cells with a cytotoxic expression profile are lacking. staining. With this top-down approach, we performed an un- + Human CD8 T cells can be divided into IFN-γ– and IL-2–producing biased RNA-sequencing (RNA-seq) and mass spectrometry cells. Unbiased transcriptomics and proteomics analysis on cytokine- γ– – + + (MS) analyses on IFN- and IL-2 producing primary human producing fixed CD8 T cells revealed that IL-2 cells produce helper + + + CD8 Tcells.
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Identification of NTN4, TRA1, and STC2 As Prognostic Markers in Breast Cancer in a Screen for Signal Sequence Encoding Proteins
Human Cancer Biology Identification of NTN4, TRA1,andSTC2 as Prognostic Markers in Breast Cancer in a Screen for Signal Sequence Encoding Proteins Selma Esseghir,1Alan Kennedy,1Pooja Seedhar,2 Ashutosh Nerurkar,3 Richard Poulsom,2 Jorge S. Reis-Filho,1and Clare M. Isacke1 Abstract Purpose: In a previous screen using a signal-trap library, we identified a number of secreted pro- teins up-regulated in primary tumor cells isolated from invasive breast cancers.The purpose of this study was to assess the expression of these genes in human invasive breast tumors and to deter- mine the significance of their expression for prognosis in breast cancer. Experimental Design: A tissue microarray containing 245 invasive breast tumors from women treated with curative surgery followed by anthracycline-based chemotherapy and hormone ther- apy for the estrogen receptor (ER)^ positive tumors was screened by in situ hybridization with probes against thrombospondin 3 (TSP3), insulin-like growth factor binding protein 7 (IGFBP7), tumor rejection antigen 1 (TRA1), stanniocalcin 2 (STC2),andnetrin4(NTN4). Correlations be- tween categorical variables were done using the m2 test and Fisher’s exact test. Cumulative sur- vival probabilities were calculated using the Kaplan-Meier method and multivariate survival analysis was done with Cox hazard model. A series of breast cancers were also stained with NTN4 antibodies. Results: All five genes examined were expressed in invasive breast tumor cells. NTN4 protein expression was also confirmed by immunohistochemistry.Together, these data validate the design and screening of the signal-trap library. Univariate survival analysis revealed that expressions of TRA1, STC2 ,andNTN4 are correlated with longer disease-free survival and thatTRA1 and NTN4 are associated with longer overall survival.
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A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family
Rockefeller University Digital Commons @ RU Student Theses and Dissertations 2018 A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family Linda Molla Follow this and additional works at: https://digitalcommons.rockefeller.edu/ student_theses_and_dissertations Part of the Life Sciences Commons A HIGH-THROUGHPUT APPROACH TO UNCOVER NOVEL ROLES OF APOBEC2, A FUNCTIONAL ORPHAN OF THE AID/APOBEC FAMILY A Thesis Presented to the Faculty of The Rockefeller University in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy by Linda Molla June 2018 © Copyright by Linda Molla 2018 A HIGH-THROUGHPUT APPROACH TO UNCOVER NOVEL ROLES OF APOBEC2, A FUNCTIONAL ORPHAN OF THE AID/APOBEC FAMILY Linda Molla, Ph.D. The Rockefeller University 2018 APOBEC2 is a member of the AID/APOBEC cytidine deaminase family of proteins. Unlike most of AID/APOBEC, however, APOBEC2’s function remains elusive. Previous research has implicated APOBEC2 in diverse organisms and cellular processes such as muscle biology (in Mus musculus), regeneration (in Danio rerio), and development (in Xenopus laevis). APOBEC2 has also been implicated in cancer. However the enzymatic activity, substrate or physiological target(s) of APOBEC2 are unknown. For this thesis, I have combined Next Generation Sequencing (NGS) techniques with state-of-the-art molecular biology to determine the physiological targets of APOBEC2. Using a cell culture muscle differentiation system, and RNA sequencing (RNA-Seq) by polyA capture, I demonstrated that unlike the AID/APOBEC family member APOBEC1, APOBEC2 is not an RNA editor. Using the same system combined with enhanced Reduced Representation Bisulfite Sequencing (eRRBS) analyses I showed that, unlike the AID/APOBEC family member AID, APOBEC2 does not act as a 5-methyl-C deaminase.
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bioRxiv preprint doi: https://doi.org/10.1101/2020.08.21.261016; this version posted August 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis Matthew J Ford1, Keerthana Harwalkar1, Alain S Pacis2, Helen Maunsell1, Yu Chang Wang3,4, 5 Dunarel Badescu3,4, Katie Teng1, Nobuko Yamanaka1, Maxime Bouchard5, Jiannis Ragoussis3,4,6, Yojiro Yamanaka1* 1) Rosalind and Morris Goodman Cancer Research Centre, Department of Human Genetics, McGill University, Montreal, QC H3A 1A3, Canada. 10 2) Canadian Centre for Computational Genomics (C3G), Genome Quebec Innovation Centre, McGill University, Montreal, H3A 1A4 Quebec, Canada. 3) Department of Human Genetics, McGill University, Montreal, H3A OC7, Quebec, Canada. 15 4) McGill University and Genome Centre, Montreal, H3A 1A4, Quebec, Canada. 5) Rosalind and Morris Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, H3A 1A3 Quebec, Canada. 20 6) Department of Bioengineering, McGill University, H3A 0C3, Quebec, Canada * Corresponding author/lead contact: [email protected] 25 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.21.261016; this version posted August 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.
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Stanniocalcin 2 Improved Osteoblast Differentiation Via Phosphorylation of ERK
MOLECULAR MEDICINE REPORTS 14: 5653-5659, 2016 Stanniocalcin 2 improved osteoblast differentiation via phosphorylation of ERK JUAN ZHOU1*, YINGHUA LI1*, LINA YANG1, YOUGEN WU1, YUNJIAO ZHOU1, YUNQING CUI1, GONG YANG1-3 and YANG HONG1,4 1Central Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240; 2Cancer Institute; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032; 4Department of Osteology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China Received October 1, 2015; Accepted October 14, 2016 DOI: 10.3892/mmr.2016.5951 Abstract. Mammalian stanniocalcin 2 (STC2) is a glyco- neuroblastoma and laryngeal squamous cell cancer (3-9). protein hormone with multiple functions. The present study Conversely, STC2 has been identified to reduce the migration determined the importance of STC2 in osteoblast differentia- and invasion of breast tumor cells (10). STC2 may also affect tion. It was revealed that the expression of STC2 was increased postnatal growth and animal size (11-13). Notably, STC2 may during the differentiation of MC3T3-E1 cells to osteoblasts be stimulated by retinoic acid and vitamin D3 (14,15), two and that knockdown of STC2 reduced osteoblast differen- important triggers for osteoblast differentiation, indicating a tiation and mineralization, whereas STC2 overexpression possible function of STC2 in osteogenesis. increased differentiation and mineralization. Knockdown of Extracellular signal-regulated kinase 1/2 (ERK1/2) is STC2 downregulated the expression of osteoblast-associated important for numerous cellular responses, including cell genes, including runt-related transcription factor 2, collagen proliferation, differentiation and survival. ERK may be acti- type I α 1 chain, osterix and osteocalcin.
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Combined GWAS and 'Guilt by Association'-Based Prioritization Analysis Identifies Functional Candidate Genes for Body Size
Combined GWAS and ‘guilt by association’-based prioritization analysis identifies functional candidate genes for body size in sheep Antonios Kominakis, Ariadne L. Hager-Theodorides, Evangelos Zoidis, Aggeliki Saridaki, George Antonakos, George Tsiamis To cite this version: Antonios Kominakis, Ariadne L. Hager-Theodorides, Evangelos Zoidis, Aggeliki Saridaki, George An- tonakos, et al.. Combined GWAS and ‘guilt by association’-based prioritization analysis identifies functional candidate genes for body size in sheep. Genetics Selection Evolution, BioMed Central, 2017, 49 (1), pp.41. 10.1186/s12711-017-0316-3. hal-01516195 HAL Id: hal-01516195 https://hal.archives-ouvertes.fr/hal-01516195 Submitted on 28 Apr 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Kominakis et al. Genet Sel Evol (2017) 49:41 DOI 10.1186/s12711-017-0316-3 Genetics Selection Evolution RESEARCH ARTICLE Open Access Combined GWAS and ‘guilt by association’‑based prioritization analysis identifes functional candidate genes for body size in sheep Antonios Kominakis1, Ariadne L. Hager‑Theodorides1*, Evangelos Zoidis1, Aggeliki Saridaki2, George Antonakos3 and George Tsiamis2 Abstract Background: Body size in sheep is an important indicator of productivity, growth and health as well as of environmen‑ tal adaptation.
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Integration of Molecular Interactome and Targeted Interaction Analysis To
www.nature.com/scientificreports OPEN Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a Received: 2 November 2017 Accepted: 20 August 2018 COPD Disease Network Module Published: xx xx xxxx Amitabh Sharma1,3,4,5, Maksim Kitsak4, Michael H. Cho 1,2,3, Asher Ameli1,10, Xiaobo Zhou1,3, Zhiqiang Jiang1, James D. Crapo6, Terri H. Beaty 7, Jörg Menche8, Per S. Bakke9, Marc Santolini 1,4,5 & Edwin K. Silverman1,2,3 The polygenic nature of complex diseases ofers potential opportunities to utilize network-based approaches that leverage the comprehensive set of protein-protein interactions (the human interactome) to identify new genes of interest and relevant biological pathways. However, the incompleteness of the current human interactome prevents it from reaching its full potential to extract network-based knowledge from gene discovery eforts, such as genome-wide association studies, for complex diseases like chronic obstructive pulmonary disease (COPD). Here, we provide a framework that integrates the existing human interactome information with experimental protein- protein interaction data for FAM13A, one of the most highly associated genetic loci to COPD, to fnd a more comprehensive disease network module. We identifed an initial disease network neighborhood by applying a random-walk method. Next, we developed a network-based closeness approach (CAB) that revealed 9 out of 96 FAM13A interacting partners identifed by afnity purifcation assays were signifcantly close to the initial network neighborhood. Moreover, compared to a similar method (local radiality), the CAB approach predicts low-degree genes as potential candidates. The candidates identifed by the network-based closeness approach were combined with the initial network neighborhood to build a comprehensive disease network module (163 genes) that was enriched with genes diferentially expressed between controls and COPD subjects in alveolar macrophages, lung tissue, sputum, blood, and bronchial brushing datasets.
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Comprehensive Analysis Reveals Novel Gene Signature in Head and Neck Squamous Cell Carcinoma: Predicting Is Associated with Poor Prognosis in Patients
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Identification of the IFITM Family As a New Molecular Marker in Human Colorectal Tumors
Research Article Identification of the IFITM Family as a New Molecular Marker in Human Colorectal Tumors Pauline Andreu,1 Sabine Colnot,1 Cećile Godard,1 Pierre Laurent-Puig,2 Dominique Lamarque,3 Axel Kahn,1 Christine Perret,1 and Beátrice Romagnolo1 1Institut Cochin, INSERM U567, Centre National de la Recherche Scientifique UMR8104, Universite´Paris V; 2Universite´Paris-Descartes, INSERM, AP-HP, UFR des Sts Pe`resUMR-S490 Laboratoire de Toxicologie Molećulaire; and 3Unite´d’He´pato-Gastroente´rologie,Hotel-Dieu, Notre Dame, Paris, France Abstract diagnosis. It is well established that one of the initiating steps in We analyzed the expression profiles of intestinal adenomas colorectal carcinogenesis is a mutation in the APC tumor from a new murine familial adenomatous polyposis model suppressor gene. APC mutations, which generally lead to a # f (Apc 14/+) using suppression subtractive hybridization to truncated protein, have been detected in 80% of sporadic cancers and cause familial adenomatous polyposis (FAP; ref. 8). identify novel diagnostic markers of colorectal carcinogenesis. h We identified 18 candidate genes having increased expression APC binds to -catenin and regulates the activation of the Wnt/ h-catenin pathway. Activation of the Wnt pathway leads to the levels in the adenoma. Subsequent Northern blotting, real- h time reverse transcription-PCR, and in situ hybridization association of -catenin with the Tcf/lef transcription factors (9). analysis confirmed their induction in B-catenin-activated This complex can activate the transcription of a variety of target genes. Loss of Apc function leads to an abnormal accumulation of epithelial cells of murine adenomas.
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Involvement of Stanniocalcins in the Deregulation of Glycaemia in Obese Mice and Type 2 Diabetic Patients
J. Cell. Mol. Med. Vol 22, No 1, 2018 pp. 684-694 Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients Jose Javier Lopez a, #, Isaac Jardın a, #, Carlos Cantonero Chamorro a, Manuel Luis Duran b, Marıa Jose Tarancon Rubio b, Maria Reyes Panadero b, Francisca Jimenez c, Rocio Montero c, Marıa Jose Gonzalez c, Manuel Martınez c, Marıa Jose Hernandez c, Jose Marıa Brull d, Antonio Jesus Corbacho d, Elena Delgado d, Marıa Purificacion Granados e, Luis Gomez-Gordo f, Juan Antonio Rosado a, Pedro Cosme Redondo a, * a Department of Physiology (Phycell), Veterinary Faculty, University of Extremadura, Caceres, Spain b Animal House of University of Extremadura, University of Extremadura, Caceres, Spain c Manuel Encinas’s medical center, Extremadura Health Service, Caceres, Spain d Extremadura County blood bank, Merida, Spain e Aldea Moret’s medical center, Extremadura Health Service, Caceres, Spain f Department of Animal Medicine, Veterinary Faculty, University of Extremadura, Caceres, Spain Received: January 24, 2017; Accepted: July 19, 2017 Abstract Stanniocalcins are expressed in the pancreas tissue, and it was suggested a direct correlation between circulating insulin and STC2 concentra- tions in human. Here, we show a significant correlation between STC1 and both glycaemia and glycosylated haemoglobin among DM2 patients, while DM2 patients who present the greatest glycosylated haemoglobin values exhibited the lowest STC2 expression. However, treatment of patients with antiglycaemic drugs does not significantly modify the expression of both STCs. On the other hand, STC2-/- mice that exhibited neonatal and adult overweight further presented deregulated glycaemia when they were feed with a hypercaloric diet (breeding pellet, BP).
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