DOCSLIB.ORG

British Journal of Urology International( April 2005 )

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
British Journal of Urology International( April 2005 ) British Journal of Urology International April 2005 - Vol. 95 Issue 6 Page i-927 i Editor's comment Online publication date: 24-Mar-2005 Comments 723 Robotic urology in the UK: establishing a programme and emerg Prokar Dasgupta, Ashok Hemal, Kirsten Rose, the Guy's and St. Online publication date: 24-Mar-2005 724 Laparoscopic reconstructive urology Sravanti P. Tegavarupu, Prokar Dasgupta Online publication date: 24-Mar-2005 726 Drug-eluting biomaterials in urology: the time is ripe Bodo E. Knudsen, Ben H. Chew, John D. Denstedt Online publication date: 24-Mar-2005 727 The European working-time directive: one step forward, two ste Majid Shabbir, Peter Amoroso, Roger S. Kirby Online publication date: 24-Mar-2005 Mini-reviews 729 Peyronie's disease: the epidemiology, aetiology and clinical eval Christopher J. Smith, Chelsea McMahon, Ridwan Shabsigh Online publication date: 24-Mar-2005 733 Recent advances in understanding the biology of diabetes-associ and novel therapy Naoki Yoshimura, Michael B. Chancellor, Karl-Erik Andersson Online publication date: 24-Mar-2005 739 Molecular prognostic factors in bladder cancer Maurizio Buscarini, Marcus L. Quek, Parkash Gill, Guangbin Xia, David I. Quinn, John P. Stein Online publication date: 24-Mar-2005 743 An evidence-based approach to understanding the pharmacological class effect in the management of prostatic diseases Christopher P. Evans, Neil Fleshner, John M. Fitzpatrick, Alexander R. Zlotta Online publication date: 24-Mar-2005 Urological Oncology 751 Radical prostatectomy for clinically advanced (cT3) prostate cancer since the advent of prostate-specific antigen testing: 15-year outcome John F. Ward, Jeffrey M. Slezak, Michael L. Blute, Erik J. Bergstralh, Horst Zincke Online publication date: 24-Mar-2005 757 The influence of bladder neck mucosal eversion and early urinary extravasation on patient outcome after radical retropubic prostatectomy: a prospective controlled trial Miguel Srougi, Mario Paranhos, Kátia M. Leite, Marcos Dall'oglio, Luciano Nesrallah Online publication date: 24-Mar-2005 761 Prostate-specific antigen (PSA) complexed to 1-antichymotrypsin improves prostate cancer detection using total PSA in Japanese patients with total PSA levels of 2.0 4.0 ng/mL Takashi Kobayashi, Toshiyuki Kamoto, Koji Nishizawa, Kenji Mitsumori, Keiji Ogura, Yoshihiro Ide Online publication date: 24-Mar-2005 766 A novel technique for approaching the endopelvic fascia in retropubic radical prostatectomy, based on an anatomical study of fixed and fresh cadavers Atsushi Takenaka, Ryoei Hara, Hideo Soga, Gen Murakami, Masato Fujisawa Online publication date: 24-Mar-2005 772 The incidence and treatment of lymphoceles after radical retropubic prostatectomy Ruth J. Pepper, Jhumur Pati, Amir V. Kaisary Online publication date: 24-Mar-2005 776 Testosterone recovery and changes in bone mineral density after stopping long-term luteinizing hormone-releasing hormone analogue therapy in osteoporotic patients with prostat cancer Robin Weston, Asad Hussain, Emmanuel George, Nigel J. Parr Online publication date: 24-Mar-2005 780 Sexual, psychological and dyadic qualities of the prostate cancer 'couple' Cynthia T. Soloway, Mark S. Soloway, Sandy S. Kim, Bruce R. Kava Online publication date: 24-Mar-2005 786 Correlation between clinical and pathological staging in a series of radical cystectomies for bladder carcinoma Vincenzo Ficarra, Orietta Dalpiaz, Najati Alrabi, Giacomo Novara, Antonio Galfano, Walter Artibani Online publication date: 24-Mar-2005 791 A comparison of the pathology of transitional cell carcinoma of the bladder and upper urinary tract Grant D. Stewart, Simon V. Bariol, Ken M. Grigor, David A. Tolley, S. Alan McNeill Online publication date: 24-Mar-2005 794 The assessment of patient life-expectancy: how accurate are urologists and oncologists? James R.M. Wilson, Michael G. Clarke, Paul Ewings, John D. Graham, Ruaraidh MacDonagh Online publication date: 24-Mar-2005 Lower Urinary Tract 799 Towards a better understanding of involuntary detrusor activity Helen D. Bradshaw, Stephen C. Radley, Derek J. Rosario, Christopher R. Chapple Online publication date: 24-Mar-2005 804 The pharmacokinetics of 400 µg of oral desmopressin in elderly patients with nocturia, and the correlation between the absorption of desmopressin and clinical effect Gitte M. Hvistendahl, Anders Riis, Jens P. Nørgaard, Jens C. Djurhuus Online publication date: 24-Mar-2005 810 Self-assessed health, sadness and happiness in relation to the total burden of symptoms from the lower urinary tract Gabriella Engström, Lars Henningsohn, Gunnar Steineck, Jerzy Leppert Online publication date: 24-Mar-2005 816 Nocturia in relation to somatic health, mental health and pain in adult men and women Ragnar Asplund, Sven-Uno Marnetoft, John Selander, Bengt Åkerström Online publication date: 24-Mar-2005 820 Nocturia, depression and antidepressant medication Ragnar Asplund, Susanne Johansson, Svante Henriksson, Göran Isacsson Online publication date: 24-Mar-2005 824 Combined external urethral bulking and artificial urinary sphincter for urethral atrophy and stress urinary incontinence Nadeem U. Rahman, Thomas X. Minor, Donna Deng, Tom F. Lue Online publication date: 24-Mar-2005 827 Day-case sling surgery for stress urinary incontinence: feasibility and safety Subhasis K. Giri, John Drumm, Jean A. Saunders, Jane McDonald, Hugh D. Flood Online publication date: 24-Mar-2005 833 A stereological analysis of fibrosis and inflammatory reaction induced by four different synthetic slings Marcelo Thiel, Paulo C. Rodrigues Palma, Cássio L.Z. Riccetto, Miriam Dambros, Nelson R. Netto Jr Online publication date: 24-Mar-2005 838 Sacral magnetic stimulation in non-inflammatory chronic pelvic pain syndrome Thomas Leippold, Raeto T. Strebel, Mirjam Huwyler, Hubert A. John, D. Hauri, Daniel M. Schmid Online publication date: 24-Mar-2005 Sexual Medicine 843 Use of combined intracorporal injection and a phosphodiesterase-5 inhibitor therapy for men with a suboptimal response to sildenafil and/or vardenafil monotherapy after radical retropubic prostatectomy Jack H. Mydlo, Rosalia Viterbo, Paul Crispen Online publication date: 24-Mar-2005 847 The effect on erectile function of 103palladium implantation for localized prostate cancer Anton Ponholzer, Renée Oismüller, Canatay Somay, Felix Büchler, Ulrich Maier, Robert Hawliczek, Michael Rauchenwald, Stephan Madersbacher Online publication date: 24-Mar-2005 Upper Urinary Tract 851 Comparison of laparoscopic and open donor nephrectomy: a randomized controlled trial Nasser Simforoosh, Abbas Basiri, Ali Tabibi, Nasser Shakhssalim, Seyed M.M. Hosseini Moghaddam Online publication date: 24-Mar-2005 Reconstructive Urology 857 Determination of the time required for appropriate chemical de- epithelialization of an ileal segment for cystoplasty: an animal model Jalal Bakhtiari, Hamid Reza Fattahian, Mohammad Javad Gharagozlou, Abdolmohammad Kajbafzadeh, Seyed Reza Jafarzadeh Online publication date: 24-Mar-2005 Paediatric Urology 863 The laparoscopic management of intersex patients: the preferred approach Francisco T. Dénes, Marcelo A.S. Cocuzza, Edison D. Schneider- Monteiro, Frederico A.Q. Silva, Elaine M.F. Costa, Berenice B. Mendonca, Sami Arap Online publication date: 24-Mar-2005 868 Predictive factors of ultrasonographic involution of prenatally detected multicystic dysplastic kidney Eli Armando S. Rabelo, Eduardo A. Oliveira, Guilherme Souza Silva, Isabela Leite Pezzuti, Edson Samesina Tatsuo Online publication date: 24-Mar-2005 Investigative Urology 874 The promise of gene-expression analysis in bladder cancer: a clinician's guide Steven C. Smith, Gary Oxford, Dan Theodorescu Online publication date: 24-Mar-2005 881 Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma Philippe Paparel, Laura Curiel, Sabrina Chesnais, Rene Ecochard, Jean- Yves Chapelon, Albert Gelet Online publication date: 24-Mar-2005 886 Stereotactic electrical stimulation of the pontine micturition centre in the pig Asger L. Dalmose, Carsten R. Bjarkam, Jens Christian Djurhuus Online publication date: 24-Mar-2005 890 Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat Zhou-Jun Shen, Hua Wang, Ying-Li Lu, Xie-Lai Zhou, Shan-Wen Chen, Zhao-Dian Chen Online publication date: 24-Mar-2005 895 Assessment of microheterogeneity of blood flow in the rat urinary bladder by high-resolution digital radiography Takahiro Kimura, Tokunori Yamamoto, Atsushi Sone, Atsushi Takenaka, Masato Fujisawa Online publication date: 24-Mar-2005 Pharmaceutical review 899 Back to the future for urological drug development? Michael G. Wyllie Online publication date: 24-Mar-2005 Points of Technique 901 Modified tubularized transverse preputial island flap repair for severe proximal hypospadias Rakesh P. Patel, Aseem R. Shukla, J. Christopher Austin, Douglas A. Canning Online publication date: 24-Mar-2005 905 Tubeless and stentless percutaneous nephrolithotomy Vikas Gupta, Trilok C. Sadasukhi, Krishan K. Sharma, Ram G. Yadav, Rajeev Mathur Online publication date: 24-Mar-2005 Letters 907 The molecular staging of prostate cancer George Yardy, Stephen McGregor, Walter Bodmer Online publication date: 24-Mar-2005 907 Prostate size influences the outcome after presenting with acute urinary retention Alan McNeill Online publication date: 24-Mar-2005 908 Robotically assisted surgery Christopher G. Eden Online publication date: 24-Mar-2005 09 Prostate cancers
Load more

Recommended publications
  • British Journal of Urology International July 2005 - Vol
    British Journal of Urology International July 2005 - Vol. 96 Issue 1 Page i-205 i Editor's comment Online publication date: 17-Jun-2005 Comments 1 Beyond marketing: the real value of robotic radical prostatectomy Anthony J. Costello Online publication date: 17-Jun-2005 2 Prolonging survival in prostate cancer: chemotherapy will have an important role Chris Parker, Mark Emberton Online publication date: 17-Jun-2005 3 -acylmethyl co-enzyme A racemase: a tumour marker for the 21st century? Debashis Das, Prokar Dasgupta, Asish Chandra Online publication date: 17-Jun-2005 4 The 'flare' phenomenon: should we be concerned? Ramesh Thurairaja, Rajendra Persad, John Peters, Amit Bahl Online publication date: 17-Jun-2005 Mini-reviews 7 Molecular staging of bladder cancer Anirban P. Mitra, Ram H. Datar, Richard J. Cote Online publication date: 17-Jun-2005 13 The role of hand-assisted laparoscopy in urology: a critical appraisal Abhay Rane, J. Stuart Wolf Online publication date: 17-Jun-2005 17 The role of photodynamic diagnosis in the contemporary management of superficial bladder cancer Sunjay Jain, Roger C. Kockelbergh Online publication date: 17-Jun-2005 22 Nonsurgical factors in the success of hypospadias repair Christopher R.J. Woodhouse, Deborah Christie Online publication date: 17-Jun-2005 Urological Oncology 29 Racial differences in serum prostate-specific antigen (PSA) doubling time, histopathological variables and long-term PSA recurrence between African-American and white American men undergoing radical prostatectomy for clinically localized prostate cancer Ashutosh Tewari, Wolfgang Horninger, Ketan K. Badani, Mazen Hasan, Steven Coon, E. David Crawford, Eduard J. Gamito, John Wei, David Taub, James Montie, Chris Porter, George W.
    [Show full text]
  • Pagina 1 Di 304 SBBL - SPRINGER E-BOOKS : TITOLI CORRENTI 2014 N
    SBBL - SPRINGER E-BOOKS : TITOLI CORRENTI 2014 N. Book Title Author Year Editore n. 1 (Endo)symbiotic Methanogenic Archaea Johannes H.P. Hackstein 2010 Springer Berlin Heidelberg n. 2 20 Years of Computational Neuroscience Tim R. New 2011 Springer Netherlands n. 3 25 Years of p53 Research James M Bower 2013 Springer New York n. 4 34th Hemophilia Symposium Pierre Hainaut, Klas G. Wiman 2005 Springer Netherlands n. 5 35th Hemophilia Symposium I. Scharrer, W. Schramm 2005 Springer Berlin Heidelberg n. 6 36th Hemophilia Symposium Hamburg 2005 Inge Scharrer, Wolfgang Schramm 2006 Springer Berlin Heidelberg n. 7 37th Hemophilia Symposium Inge Scharrer, Wolfgang Schramm 2007 Springer Berlin Heidelberg n. 8 3D Histology Evaluation of Dermatologic Surgery Inge Scharrer, Wolfgang Schramm 2008 Springer Berlin Heidelberg n. 9 41es Journées nationales de la Société Française de Médecine Périnatale (Grenoble 12–14 octobre 2011) Helmut Breuninger, Patrick Adam 2013 Springer London n. 10 42es Journées nationales de la Société Française de Médecine Périnatale (Montpellier 17–19 octobre 2012) Société Française de Médecine Périnatale 2011 Springer Paris n. 11 50 Years of Phytochemistry Research Société Française de Médecine Périnatale 2013 Springer Paris n. 12 55 Years German Society of Anaesthesiology and Intensive Care Medicine David R. Gang 2013 Springer International Publishing n. 13 5-HT2C Receptors in the Pathophysiology of CNS Disease J. Schüttler 2012 Springer Berlin Heidelberg n. 14 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo 2011 Humana Press n. 15 7.0 Tesla MRI Brain Atlas M.
    [Show full text]
  • Final1-223234-1128453-Finalreport-03.Pdf
    O PROJECT FINAL REPORT Grant Agreement number: 223234 Project acronym: INCOMB Project title: Combating Incontinence, from basic science to clinical practice Funding Scheme: FP7-CP-FP Period covered: from 2008-12-01 to 2012-05-31 1 Name of the scientific representative of the project's co-ordinatorPF F,P Prof. Anders Arner Department of Physiology and Pharmacology Karolinska Institutet SE 171 77 Stockholm Sweden Tel: +46 8 524 87221 E-mail: [email protected] Project website address: www.INComb.eu 1 TP PT Usually the contact person of the coordinator as specified in Art. 8.1. of the Grant Agreement. 4.1 Final publishable summary report 4.1.1 Executive summary Urinary incontinence and the problems of urgency and frequency of micturition are conditions affecting a large number of European citizens. An “over active bladder” (OAB) due to involuntary bladder muscle contractions is the major cause of urgency incontinence. Although this and other lower urinary tract symptoms do not constitute life threatening disorders, they do have serious negative impact on the quality of life and major effects on health economy. Several therapies are used to treat urgency incontinence. However, currently, these treatments are imperfect or are associated with adverse side effects which reduce patient compliance. The INComb project, “Combating incontinence” (www.INComb.eu), was initiated, with the aims of establishing a better understanding of the pathogenesis of bladder overactivity, improving diagnostic tests and developing novel intervention strategies. The urinary bladder is a complex organ where different cell types and tissues influence the filling and emptying of urine. The project has addressed objectives related to the communication between the different cell types and has developed novel techniques to measure signalling components in urinary bladder tissue.
    [Show full text]
  • Book Title Author Copyright Year Editore N.1 (Endo)Symbiotic Methanogenic Archaea Johannes H.P
    SBBL - SPRINGER E-BOOKS : TITOLI CORRENTI 2013 Book Title Author Copyright Year Editore n.1 (Endo)symbiotic Methanogenic Archaea Johannes H.P. Hackstein 2010 Springer n.2 ‘In Considerable Variety’: Introducing the Diversity of Australia’s Insects Tim R. New 2011 Springer n.3 25 Years of p53 Research Pierre Hainaut, Klas G. Wiman 2005 Springer n.4 34th Hemophilia Symposium I. Scharrer, W. Schramm 2005 Springer n.5 35th Hemophilia Symposium Inge Scharrer, Wolfgang Schramm 2006 Springer n.6 36th Hemophilia Symposium Hamburg 2005 Inge Scharrer, Wolfgang Schramm 2007 Springer n.7 37th Hemophilia Symposium Inge Scharrer, Wolfgang Schramm 2008 Springer n.8 41es Journées nationales de la Société Française de Médecine Périnatale (Grenoble 12–14 octobre 2011) Société Française de Médecine Périnatale 2011 Springer n.9 42es Journées nationales de la Société Française de Médecine Périnatale (Montpellier 17–19 octobre 2012) Société Française de Médecine Périnatale 2013 Springer n.10 55 Years German Society of Anaesthesiology and Intensive Care Medicine J. Schüttler 2012 Springer n.11 5-HT2C Receptors in the Pathophysiology of CNS Disease Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo 2011 Springer n.12 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center M. Alma Rodriguez, Ronald S. Walters, Thomas W. Burke 2013 Springer n.13 7.0 Tesla MRI Brain Atlas Zang-Hee Cho 2010 Springer n.14 99mTc-Sestamibi Jan Bucerius, Hojjat Ahmadzadehfar, Hans-Jürgen Biersack 2012 Springer n.15 A Blueprint for Promoting Academic and Social Competence in After-School Programs Thomas P. Gullotta, Martin Bloom, Christianne F.
    [Show full text]
  • Helping Patients Counter Obesity by Achieving Enduring Lifestyle Change
    Place comment_Layout 1 16/11/2011 09:36 Page 1 COMMENT 39 Getting to a better ‘PLACE’: helping patients counter obesity by achieving enduring lifestyle change ROGER KIRBY, MICHAEL KIRBY, PETER AMOROSO, BEN CHALLACOMBE, PROKAR DASGUPTA, CULLEY CARSON III AND JOHN M. FITZPATRICK In the domain of public health, common sense is not always common practice. How best then to enable patients to act on the advice that they have constantly heard, but find hard to actually carry out? besity, especially male-pattern modifications that can help to Oabdominal obesity, is strongly achieve, and maintain, significant correlated with hypertension, diabetes, weight reduction. dyslipidaemia and consequent cardiovascular risk.1 It is also linked with We advise our patients to ‘get to erectile dysfunction (ED) and increased risk a better PLACE’ and achieve the of benign prostatic hyperplasia (BPH), as balance between energy intake well as greater morbidity after treatment and calorie use that provides for prostate cancer.2 Although diets the key to weight reduction. low in carbohydrates and energy-rich A mnemonic of five simple rules fats are often successful in achieving acts as an aide mémoire for both clinician weight reduction, their impact is often and patient (Figure 1): Figure 1. Getting to a better PLACE disappointingly short-lived, so that their (patient handout available from long-term efficacy is limited. A urologist is ortion control. Generally speaking, the www.trendsinurology.com/patientinformation) frequently the first clinician that a patient, Pportions of energy-rich foods, eaten especially a middle-aged male patient, both at and away from home, are much comes into contact with.
    [Show full text]
  • Huntprg2 1..4
    HUNTERIAN SOCIETY Programme of 187th Session 2012±2013 President: Professor Prokar Dasgupta Programme of 187th Session 2012 Monday 24th September ± Inaugural Meeting 6.30±8.30pm The Hunterian Museum: Professor Harold Ellis CBE, FRCS Cutting of the Stone ± History of the Bladder Stone Royal College of Surgeons of England Lincolns Inn Fields WC2A 3PE Presentation of the Hunterian Scholarships Thursday 4th October ± 4.45pm Westminster Abbey Commemoration of the Anniversary of the Death of John Hunter on October 16th 1793 Evensong followed by a supper at The Cinnamon Club 30±32 Great Smith Street SW1P 3BU Monday 29th October ± Scientific Dinner Meeting Council Meeting 6.00pm Medical Society of London 11 Chandos Street W1G 9EB Dr Nicholas Cambridge, MD, MRCS From the Slaughter House of Blood to Mr Pickwick: Charles Dickens and Medicine Monday 19th November ± Presidential Address Medical Society of London 11 Chandos Street W1G 9EB Professor Prokar Dasgupta, MSc, DLS, MD, FRCS, FRCS(Urol), FEBU Botulinum Toxin ± from Deadly Poison to Urology * Timetable for meetings unless otherwise stated 7.00pm Reception and Dinner 8.15pm Scientific Meeting { 9.30pm End { Fellows may attend the Scientific Meeting only. Programme of 187th Session 2013 Monday 21st January ± Hunterian Prize Papers & Award Council Meeting 6.00pm Medical Society of London 11 Chandos Street W1G 9EB Tuesday 5th February ± Guest Lecture and Anniversary Dinner The Athenaeum 107 Pall Mall SW1 5ER Professor Clare Fowler, CBE, MSc, FRCP The Bladder and its Nerve Supply Monday 18th March ± Hunterian Oration Medical Society of London 11 Chandos Street W1G 9EB Professor Roger Kirby, MA, MD, FRCS, FEBU The Prostate ± Hunter and Beyond Monday 15th April ± Hunterian Lecture Council Meeting 6.00pm Medical Society of London 11 Chandos Street W1G 9EB Mr Andy Leather, MS, FRCS Applying Hunterian Principles to the Challenges of Global Health Monday 20th May ± Annual General Meeting and Scientific Dinner Meeting Medical Society of London 11 Chandos Street W1G 9EB Dr Stuart McDonald BSc, MB.ChB., PhD.
    [Show full text]
  • Prostate Cancer: a Comprehensive Perspective Ash Tewari, MD Ronald P
    Prostate Cancer: A Comprehensive Perspective Ash Tewari, MD Ronald P. Lynch Professor of Urologic-Oncology Director Weill Cornell Medical College and New York Presbyterian Hospital Center for Prostate Cancer Research and Clinical Care (CPCR&CC) Director Lefrak Center of Robotic Surgery, NYPH Ashutosh Tewari Editor Prostate Cancer: A Comprehensive Perspective Editor Ashutosh Tewari New York Presbyterian Hospital Brady Urologic Health Center Weill Cornell Medical Center New York New York USA ISBN 978-1-4471-2863-2 ISBN 978-1-4471-2864-9 (eBook) DOI 10.1007/978-1-4471-2864-9 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013931841 © Springer-Verlag London 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center.
    [Show full text]
  • M Eeting Program
    2019 MAY 3–6 chicago MEETING PROGRAM METS? NO METS? START XTANDI. Regardless of metastatic status, XTANDI offers your patients with castration-resistant prostate cancer (CRPC) the confi dence of proven effi cacy when PSA is rising* during LHRH therapy.†1 *PSA level ≥ 2 ng/mL with at least 2 consecutive rises despite castrate testosterone levels (≤ 50 ng/dL).2-4 Indication and Important Safety Information Indication Advise patients who experience any symptoms of hypersensitivity to temporarily discontinue XTANDI and promptly seek medical care. XTANDI (enzalutamide) is indicated for the treatment of patients with Permanently discontinue XTANDI for serious hypersensitivity reactions. castration-resistant prostate cancer (CRPC). Ischemic Heart Disease In the placebo-controlled clinical studies, Important Safety Information ischemic heart disease occurred more commonly in patients on the XTANDI arm compared to patients on the placebo arm (2.7% vs 1.2%). Warnings and Precautions Grade 3-4 ischemic events occurred in 1.2% of patients on XTANDI versus Seizure occurred in 0.4% of patients receiving XTANDI in clinical studies. 0.5% on placebo. Ischemic events led to death in 0.4% of patients on In a study of patients with predisposing factors for seizure, 2.2% of XTANDI compared to 0.1% on placebo. Monitor for signs and symptoms XTANDI-treated patients experienced a seizure. Patients in the study had of ischemic heart disease. Optimize management of cardiovascular risk one or more of the following pre-disposing factors: use of medications factors, such as hypertension, diabetes, or dyslipidemia. Discontinue that may lower the seizure threshold; history of traumatic brain or head XTANDI for Grade 3-4 ischemic heart disease.
    [Show full text]