Coast Guard, DHS Pt. 150, Table II

Total Page:16

File Type:pdf, Size:1020Kb

Coast Guard, DHS Pt. 150, Table II Coast Guard, DHS Pt. 150, Table II Group Foot- CHRIS Related CHRIS Chemical name No. note Code Codes Zinc bromide, Calcium bromide solution, see Drilling brine (containing Zinc ............ ............ DZB salts). 1. Because of very high reactivity or unusual conditions of carriage or potential compatibility problems, this commodity is not assigned to a specific group in the Compatibility Chart. For additional compatibility information, contact Commandant (G-MSO), U.S. Coast Guard, 2100 Second Street, SW., Washington, DC 20593–0001. Telephone (202) 372–1425. 2. See Appendix I—Exceptions to the Chart. [USCG 2000–7079, 65 FR 67162, Nov. 8, 2000, as amended by USCG–2006–25697, 71 FR 55746, Sept. 25, 2006; USCG–2008–0906, 73 FR 56510, Sept. 29, 2008; USCG–2009–0702, 74 FR 49236, Sept. 25, 2009; USCG–2010–0759, 75 FR 60003, Sept. 29, 2010] TABLE II TO PART 150—GROUPING OF Tall oil fatty acid, barium salt 2 CARGOES Urea, Ammonium mono- and di-hydrogen phosphate, Potassium chloride solution 0. UNASSIGNED CARGOES 1. NON-OXIDIZING MINERAL ACIDS Acetone cyanohydrin 1,2 Alkylbenzenesulfonic acid 1,2 Di-(2-ethylhexyl)phosphoric acid Aluminium chloride, Hydrochloric acid so- Ferric chloride solution lution 1 Fluorosilicic acid Ammonium hydrogen phosphate solution 1 Hydrochloric acid Ammonium nitrate solution 1 Phosphoric acid Ammonium thiocyanate, Ammonium Polyaluminum chloride solution thiosulfate solution 1 Benzenesulfonyl chloride 1,2 2. SULFURIC ACIDS gamma-Butyrolactone 1,2 Sulfuric acid 2 Chlorine 1 Sulfuric acid, spent Chlorosulfonic acid 1 Titanium tetrachloride Decyloxytetrahydro-thiophene dioxide 2 tert-Dodecanethiol 2 3. NITRIC ACID 2,4-Dichlorophenoxyacetic acid, Dimethyl- Ferric nitrate, Nitric acid solution amine salt solution 1,2 Dimethylamine salt of 2,4- Nitric acid (70% or less) 1,2 Dichlorophenoxyacetic acid solution 4. ORGANIC ACIDS Diphenylol propane-Epichlorohydrin res- ins 1 Acetic acid 2 Dodecylbenzenesulfonic acid 1,2 Acrylic acid 2 Dodecyl hydroxypropyl sulfide 2 Butyric acid Ethylene oxide 1 Cashew nut shell oil (untreated) Hydrogen peroxide solutions 1 Citric acid Lactic acid 2 Chloroacetic acid solution Long chain alkaryl sulfonic acid (C16–C60) 2 Chloropropionic acid Magnesium chloride solution 1,2 Decanoic acid Molasses residue 1 2,2-Dichloropropionic acid Motor fuel antiknock compounds con- 2,2-Dimethyloctanoic acid taining Lead alkyls 1 2-Ethylhexanoic acid Naphthalene sulfonic acid-formaldehyde Formic acid 2 copolymer, sodium salt solution 1 Glycolic acid NIAX POLYOL APP 240C 1,2 Glyoxylic acid Nitrating acid 1 n-Heptanoic acid Nitric acid (greater than 70%) 1 Hexanoic acid o-Nitrophenol 1,2 2-Hydroxy-4-(methylthio)butanoic acid Noxious Liquid Substance, n.o.s. (NLS’s) 1 Methacrylic acid Oleum 1,2 Naphthenic acid Phosphorus 1 Neodecanoic acid Phthalate based polyester polyol 2 Nonanoic acid SAP 7001 1 Nonanoic, Tridecanoic acid mixture Sodium chlorate solution 1,2 Octanoic acid Sodium dichromate solution 1,2 n-Pentanoic acid, 2-Methyl butryic acid Sodium hydrogen sulfide, Sodium car- mixture bonate solution 1,2 Pentanoic acid Sodium sulfide, Hydrosulfide solution 1,2 Propionic acid Sodium thiocyanate solution 1,2 Trimethylacetic acid Sulfur 1 Undecanoic acid 43 VerDate Mar<15>2010 11:26 Nov 15, 2010 Jkt 220195 PO 00000 Frm 00053 Fmt 8010 Sfmt 8002 Y:\SGML\220195.XXX 220195 jdjones on DSK8KYBLC1PROD with CFR Pt. 150, Table II 46 CFR Ch. I (10–1–10 Edition) 5. CAUSTICS Ethylenediamine 2 Ammonium sulfide solution 2-Ethyl hexylamine Calcium hypochlorite solutions N-Ethylmethylallylamine Caustic potash solution 2 Glyphosate solution (not containing sur- Caustic soda solution 2 factant) Cresylate spent caustic Hexamethylenediamine Cresylic acid, sodium salt solution Hexamethylenediamine solution Kraft black liquor Hexamethylenetetramine Kraft pulping liquors Hexamethylenetetramine solutions Mercaptobenzothiazol, sodium salt solu- Hexamethylenimine tion HiTec 321 Potassium hydroxide solution 2 bis-(Hydrogenated tallow alkyl)methyl Sodium acetate, Glycol, Water mixture amines (containing Sodium hydroxide) Isophorone diamine Sodium aluminate solution Long chain polyetheramine in alkyl(C2– Sodium borohydride, Sodium hydroxide so- C4)benzenes lution Metam sodium solution Sodium carbonate solutions Methylamine solutions Sodium cyanide solution Morpholine 2 Sodium hydrosulfide solution 2 Oleylamine Sodium hydrosulfide, Ammonium sulfide Pentaethylenehexamine solution 2 Sodium hydroxide solution 2 Pentaethylenehexamine, Sodium hypochlorite solution Tetraethylenepentamine mixture Sodium 2-mercaptobenzothiazol solution Phosphate esters, alkyl (C12–C14) amine Sodium naphthenate solution Polyethylene polyamines 2 Sodium nitrite solution Polyolefin amide alkeneamine (C28+) Triphenylborane, Caustic soda solution Polyisobutenamine in aliphatic (C10–C14) Trisodium phosphate solution solvent Vanillin black liquor Poly (C17+) olefin amine Polyolefin amide alkeneamine/Molyb- 6. AMMONIA denum oxysulfide mixture Ammonia, anhydrous Propanil, Mesityl oxide, Isophorone mix- Ammonia, aqueous ture Ammonium hydroxide (28% or less Ammo- Propylamine nia) iso-Propylamine solution Ammonium nitrate, Urea solution (con- Roundup taining Ammonia) Sulfohydrocarbon, long chain (C18+) Urea, Ammonium nitrate solution (con- alkylamine mixture taining Ammonia) Tetraethylenepentamine 2 Triethylamine 7. ALIPHATIC AMINES Triethylenetetramine 2 N-Aminoethylpiperazine Trimethylamine solution Butylamine Trimethylhexamethylene diamine (2,2,4- Cyclohexylamine and 2,4,4-) Dibutylamine Diethylamine 2 8. ALKANOLAMINES Diethylenetriamine 2 2-(2-Aminoethoxy)ethanol Diisobutylamine Aminoethyldiethanolamine, Diisopropylamine Aminoethylethanolamine solution Dimethylamine Aminoethylethanolamine Dimethylamine solution 2-Amino-2-methyl-1-propanol N,N-Dimethylcyclohexylamine Diethanolamine N,N-Dimethyldodecylamine Diethylaminoethanol Di-n-propylamine Diphenylamine, reaction product with Diethylethanolamine 2,2,4-Trimethylpentene Diisopropanolamine Diphenylamines, alkylated Dimethylethanolamine Dodecylamine, Tetradecylamine mixture 2 Ethanolamine Dodecyldimethylamine, Ethoxylated long chain (C16+) Tetradecyldimethylamine mixture alkyloxyalkanamine Ethylamine 2 Methyl diethanolamine Ethylamine solution Propanolamine Ethyleneamine EA 1302 2 Triethanolamine 2 N-Ethyl-n-butylamine Triisopropanolamine N-Ethyl cyclohexylamine Ucarsol CR Solvent 302 SG 44 VerDate Mar<15>2010 11:26 Nov 15, 2010 Jkt 220195 PO 00000 Frm 00054 Fmt 8010 Sfmt 8002 Y:\SGML\220195.XXX 220195 jdjones on DSK8KYBLC1PROD with CFR Coast Guard, DHS Pt. 150, Table II 9. AROMATIC AMINES Butyl methacrylate Butyl methacrylate, Decyl methacrylate, Alkyl (C8–C9) phenylamine in aromatic Cetyl-Eicosyl methacrylate mixture solvents Cetyl-Eicosyl methacrylate mixture Aniline Calcium long chain alkyl phenolic amine Decyl acrylate (C8–C40) Dodecyl methacrylate 4-Chloro-2-methylphenoxyacetic acid, Di- Dodecyl-Octadecyl methacrylate mixture methylamine salt solution Dodecyl-Pentadecyl methacrylate mixture Dialkyl (C8–C9) diphenylamines Ethyl acrylate 2,6-Diethylaniline 2-Ethylhexyl acrylate Dimethylamine salt of 4-Chloro-2- Ethyl methacrylate methylphenoxyacetic acid solution 2-Hydroxyethyl acrylate 2 2,6-Dimethylaniline Methacrylic resin in Ethylene dichloride Diphenylamine Methyl acrylate 2-Ethyl-6-methyl-N-(1′-methyl-2- Methyl methacrylate methoxyethyl)aniline Nonyl methacrylate 2-Methyl-6-ethyl aniline Polyalkyl(C18 - C22) acrylate in Xylene 2-Methyl-5-ethyl pyridine Polyalkyl (C10–C18) methacrylate/Ethylene Methyl pyridine Polyalkyl (C10–C20) methacrylate 3-Methylpyridine Propylene copolymer mixture N-Methyl-2-pyrrolidone 2 Roehm monomer 6615 Paraldehyde-Ammonia reaction product Pyridine 15. SUBSTITUTED ALLYLS Pyridine bases Acrylonitrile 2 Toluenediamine Allyl alcohol 2 p-Toluidine Allyl chloride 1,3-Dichloropropene 10. AMIDES Dichloropropene, Dichloropropane mix- Acetochlor tures Acrylamide solution Methacrylonitrile Alkenyl(C11+)amide N,N-Dimethylacetamide 16. ALKYLENE OXIDES N,N-Dimethylacetamide solution Butylene oxide Dimethylformamide Ethylene oxide, Propylene oxide mixtures Formamide Propylene oxide N,N-bis(2-Hydroxyethyl) oleamide Octadecenoamide 17. EPICHLOROHYDRIN Zinc alkenyl carboxamide Chlorohydrins 11. ORGANIC ANHYDRIDES Epichlorohydrin Acetic anhydride 18. KETONES Alkenylsuccinic anhydride Maleic anhydride Acetone 2 Phthalic anhydride Acetophenone Polyisobutenyl anhydride adduct Amyl methyl ketone Polyolefin anhydride Butyl heptyl ketone Propionic anhydride Camphor oil 1-(4-Chlorophenyl)-4,4-dimethyl pentan-3- 12. ISOCYANATES one 2 Cyclohexanone Diphenylmethane diisocyanate Cyclohexanone, Cyclohexanol mixtures 2 Hexamethylene diisocyanate Diisobutyl ketone Isophorone diisocyanate Ethyl amyl ketone Polymethylene polyphenyl isocyanate Epoxy resin Toluene diisocyanate Ketone residue Trimethylhexamethylene diisocyanate Isophorone 2 (2,2,4- and 2,4,4-) Mesityl oxide 2 13. VINYL ACETATE Methyl amyl ketone Methyl butyl ketone Vinyl acetate Methyl butyl ketone Vinyl ethyl ether Methyl ethyl ketone 2 Vinyl neodecanate Methyl heptyl ketone Vinyl toluene Methyl isoamyl ketone Methyl isobutyl ketone 2 14. ACRYLATES Methyl propyl ketone Butyl acrylate Trifluralin in Xylene 45 VerDate Mar<15>2010 11:26 Nov 15, 2010 Jkt 220195 PO 00000 Frm 00055 Fmt 8010 Sfmt 8002 Y:\SGML\220195.XXX 220195 jdjones on DSK8KYBLC1PROD with CFR Pt. 150, Table II 46 CFR Ch. I (10–1–10 Edition) 19. ALDEHYDES Methyl amyl alcohol Methyl butenol Acetaldehyde Methylbutynol Acrolein 2 2-Methyl-2-hydroxy-3-butyne Butyraldehyde Methyl isobutyl
Recommended publications
  • 36Th ITC Report
    Thursday August 17, 1995 Part V Environmental Protection Agency Thirty-Sixth Report of the TSCA Interagency Testing Committee to the Administrator; Receipt of Report, Request for Comments, Solicitation of Use and Exposure Data; Notice federal register 42981 42982 Federal Register / Vol. 60, No. 159 / Thursday, August 17, 1995 / Notices ENVIRONMENTAL PROTECTION comments and data in electronic form ``OPPTS±41043'' (including comments AGENCY must be identified by the docket number and data submitted electronically as OPPT±41043. No CBI should be described below). A public version of [OPPTS±41043; FRL±4965±6] submitted through e-mail. Electronic this record, including printed, paper Thirty-Sixth Report of the TSCA comments on this notice may be filed versions of electronic comments, which Interagency Testing Committee to the online at many Federal Depository does not include any information Administrator; Receipt of Report, Libraries. Additional information on claimed as confidential business Request for Comments, Solicitation of electronic submissions can be found in information (CBI), is available for Use and Exposure Data Unit III of this document. inspection from 12 noon to 4 p.m., FOR FURTHER INFORMATION CONTACT: Monday through Friday, excluding legal AGENCY: Environmental Protection Susan B. Hazen, Director, holidays. The public record is located in Agency (EPA). Environmental Assistance Division the TSCA Nonconfidential Information ACTION: Notice. (7408), Office of Pollution Prevention Center, Rm. NE-B607, 401 M St., SW., and Toxics, Environmental Protection Washington, DC 20460. SUMMARY: The TSCA Interagency Agency, 401 M Street, SW., Rm. E± Electronic comments can be sent Testing Committee (ITC), established 543B, Washington, DC 20460, (202) directly to EPA at: under section 4(e) of the Toxic 554±1404, TDD (202) 554±0551, [email protected] Substances Control Act (TSCA), Internet: TSCA- transmitted its Thirty-Sixth Report to [email protected].
    [Show full text]
  • Dipropylene Glycol Ethyl Ether (DPGEE) [Ethyl DIPROXITOL] Product Stewardship Summary December 2017
    DiPropylene Glycol Ethyl Ether (DPGEE) [Ethyl DIPROXITOL] Product Stewardship Summary December 2017 DiPropylene Glycol Ethyl Ether (DPGEE) [Ethyl DIPROXITOL] Product Stewardship Summary (CAS number 30025-38-8) Chemical Formula for DPGEE C8H18 O3 What is DPGEE? DPGEE is a glycol ether based on Propylene oxide and ethanol. It is a speciality solvent having a bi- functional nature (ether-alcohol). It is a clear liquid with an ethereal odour. The Shell Chemicals range of Propylene oxide-based glycol ethers are sold under the trade name PROXITOL. How is DPGEE Used? It is used as an intermediate and in formulations in industrial, professional or consumer applications, mainly in surface coatings and printing inks and paints, cleaners, agrochemical or de-icing/anti-icing formulations. Health, Safety and Environmental Considerations DPGEE is flammable liquids with a flashpoint of 180 0F/82 0C. DPGEE is an isomer mix, of which the main component is 1-Ethoxypropanol-2 (typically 98% or more). Shell PROXITOLs are not classified as carcinogens or mutagens, are not expected to cause cancer in humans, nor do they impair fertility or damage the developing foetus. DPGEE is of low toxicity towards aquatic organisms. They are completely miscible with water, biodegradable and not expected to bio-accumulate. Storing and Transporting DPGEE DPGEE is transported by tank truck, rail car and vessel, primarily in bulk quantities, but also as packed product. Due to its flammability, they are classified as hazardous for transport under transport regulations. Glycol Ethers should be stored at ambient temperatures away from sources of ignition and substances with oxidising or corrosive properties.
    [Show full text]
  • Oxidation of Amines at Absorber Conditions for CO2 Capture from Flue Gas
    Energy Procedia Energy Procedia 4 (2011) 171–178 Energy Procedia 00 (2010) 000–000 www.elsevier.com/locate/procedia www.elsevier.com/locate/XXX GHGT-10 Oxidation of amines at absorber conditions for CO2 capture from flue gas Alexander K. Voice, Gary T. Rochelle* Department of Chemical Engineering, Luminant Carbon Management Program, University of Texas, 1 University Station C0400, Austin, TX 78712, USA Elsevier use only: Received date here; revised date here; accepted date here Abstract Eleven amines that are suitable for CO2 capture by an amine scrubbing system have been evaluated for their stability in the presence of oxygen. Six amines produced measureable quantities of ammonia in the order: 1,2-diamino-propane (DAP) > monoethanolamine (MEA) > ethylene diamine (EDA) > 3-methylamino-1-propylamine (MAPA) > potassium glycinate (GLY) > potassium taurinate (TAU). Five other amines produced no detectable ammonia (<0.2mmol/kg/hr): piperazine (PZ), 1-methyl-piperazine (1-MPZ), diglycolamine (DGA®), 2-amino-2-methyl-propanol (AMP), and 1- methyl-diethanolamine (MDEA). The effect of temperature on ammonia production from aqueous MEA in the presence of Inh. A was also measured. The activation energy of ammonia production varied from 86 kJ/mol with no inhibitor to 133 kJ/mol with 200 mM Inh. A. At 55°C, ammonia production was reduced by 74-99% with 50-200 mM Inh. A. ⃝©c 20102011 Elsevier Published Ltd. by ElsevierAll rights Ltd. reserved Keywords: Oxidative degradation; amine screening; ammonia rates; activation energy. 1.0 Introduction Aqueous monoethanolamine (MEA) is the baseline solvent for carbon dioxide capture from flue gas by absorption- stripping. MEA is an attractive solvent, because it is relatively cheap, has a fast reaction rate with CO2, and has a high heat of absorption.
    [Show full text]
  • Toxicological Profile for 2-Butanone Released for Public Comment in May 2019
    Toxicological Profile for 2-Butanone October 2020 2-BUTANONE ii DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. 2-BUTANONE iii FOREWORD This toxicological profile is prepared in accordance with guidelines* developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. The adequacy of information to determine a substance's
    [Show full text]
  • R Graphics Output
    Dexamethasone sodium phosphate ( 0.339 ) Melengestrol acetate ( 0.282 ) 17beta−Trenbolone ( 0.252 ) 17alpha−Estradiol ( 0.24 ) 17alpha−Hydroxyprogesterone ( 0.238 ) Triamcinolone ( 0.233 ) Zearalenone ( 0.216 ) CP−634384 ( 0.21 ) 17alpha−Ethinylestradiol ( 0.203 ) Raloxifene hydrochloride ( 0.203 ) Volinanserin ( 0.2 ) Tiratricol ( 0.197 ) trans−Retinoic acid ( 0.192 ) Chlorpromazine hydrochloride ( 0.191 ) PharmaGSID_47315 ( 0.185 ) Apigenin ( 0.183 ) Diethylstilbestrol ( 0.178 ) 4−Dodecylphenol ( 0.161 ) 2,2',6,6'−Tetrachlorobisphenol A ( 0.156 ) o,p'−DDD ( 0.155 ) Progesterone ( 0.152 ) 4−Hydroxytamoxifen ( 0.151 ) SSR150106 ( 0.149 ) Equilin ( 0.3 ) 3,5,3'−Triiodothyronine ( 0.256 ) 17−Methyltestosterone ( 0.242 ) 17beta−Estradiol ( 0.24 ) 5alpha−Dihydrotestosterone ( 0.235 ) Mifepristone ( 0.218 ) Norethindrone ( 0.214 ) Spironolactone ( 0.204 ) Farglitazar ( 0.203 ) Testosterone propionate ( 0.202 ) meso−Hexestrol ( 0.199 ) Mestranol ( 0.196 ) Estriol ( 0.191 ) 2,2',4,4'−Tetrahydroxybenzophenone ( 0.185 ) 3,3,5,5−Tetraiodothyroacetic acid ( 0.183 ) Norgestrel ( 0.181 ) Cyproterone acetate ( 0.164 ) GSK232420A ( 0.161 ) N−Dodecanoyl−N−methylglycine ( 0.155 ) Pentachloroanisole ( 0.154 ) HPTE ( 0.151 ) Biochanin A ( 0.15 ) Dehydroepiandrosterone ( 0.149 ) PharmaCode_333941 ( 0.148 ) Prednisone ( 0.146 ) Nordihydroguaiaretic acid ( 0.145 ) p,p'−DDD ( 0.144 ) Diphenhydramine hydrochloride ( 0.142 ) Forskolin ( 0.141 ) Perfluorooctanoic acid ( 0.14 ) Oleyl sarcosine ( 0.139 ) Cyclohexylphenylketone ( 0.138 ) Pirinixic acid ( 0.137 )
    [Show full text]
  • 162 Part 175—Indirect Food Addi
    § 174.6 21 CFR Ch. I (4–1–19 Edition) (c) The existence in this subchapter B Subpart B—Substances for Use Only as of a regulation prescribing safe condi- Components of Adhesives tions for the use of a substance as an Sec. article or component of articles that 175.105 Adhesives. contact food shall not be construed as 175.125 Pressure-sensitive adhesives. implying that such substance may be safely used as a direct additive in food. Subpart C—Substances for Use as (d) Substances that under conditions Components of Coatings of good manufacturing practice may be 175.210 Acrylate ester copolymer coating. safely used as components of articles 175.230 Hot-melt strippable food coatings. that contact food include the fol- 175.250 Paraffin (synthetic). lowing, subject to any prescribed limi- 175.260 Partial phosphoric acid esters of pol- yester resins. tations: 175.270 Poly(vinyl fluoride) resins. (1) Substances generally recognized 175.300 Resinous and polymeric coatings. as safe in or on food. 175.320 Resinous and polymeric coatings for (2) Substances generally recognized polyolefin films. as safe for their intended use in food 175.350 Vinyl acetate/crotonic acid copoly- mer. packaging. 175.360 Vinylidene chloride copolymer coat- (3) Substances used in accordance ings for nylon film. with a prior sanction or approval. 175.365 Vinylidene chloride copolymer coat- (4) Substances permitted for use by ings for polycarbonate film. 175.380 Xylene-formaldehyde resins con- regulations in this part and parts 175, densed with 4,4′-isopropylidenediphenol- 176, 177, 178 and § 179.45 of this chapter.
    [Show full text]
  • Pesticides and Toxic Substances
    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES CERTIFIED MAIL Dear Registrant: This is to inform you that the Environmental Protection Agency (hereafter referred to as EPA or the Agency) has completed its review of the available data for the antimicrobials propylene glycol and dipropylene glycol. The Reregistration Eligibility Decision (RED) was approved in the form of a decision memorandum which summarized the regulatory decision for propylene glycol and dipropylene glycol on September 30, 2004. Based on its review, EPA is now publishing its Reregistration Eligibility Decision (RED) for propylene glycol and dipropylene glycol and its associated human health and environmental risks. A Notice of Availability will be published in the Federal Register announcing the publication of the RED. The RED and supporting documents for propylene glycol and dipropylene glycol will be available to the public in EPA’s Pesticide Docket EPA-HQ-OPP-2006-0831 at: www.regulations.gov. Please note that the attached RED document pertains only to propylene glycol and dipropylene glycol. This RED presents the Agency’s conclusions on the dietary, drinking water, occupational and ecological risks posed by exposure to propylene glycol or dipropylene glycol alone. This document also contains product-specific data that the Agency intends to require in Data Call-Ins (DCIs). Note that DCIs, with all pertinent instructions, will be sent to registrants at a later date. Currently, there are no generic data requirements. Additionally, for product- specific DCIs, the first set of required responses will be due 90 days from the receipt of the DCI letter.
    [Show full text]
  • Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations
    molecules Review Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations Deepak Gupta 1, Deepak Bhatia 2 ID , Vivek Dave 3 ID , Vijaykumar Sutariya 4 and Sheeba Varghese Gupta 4,* 1 Department of Pharmaceutical Sciences, School of Pharmacy, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA; [email protected] 2 ICPH Fairfax Bernard J. Dunn School of Pharmacy, Shenandoah University, Fairfax, VA 22031, USA; [email protected] 3 Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY 14618, USA; [email protected] 4 Department of Pharmaceutical Sciences, USF College of Pharmacy, Tampa, FL 33612, USA; [email protected] * Correspondence: [email protected]; Tel.: +01-813-974-2635 Academic Editor: Peter Wipf Received: 7 June 2018; Accepted: 13 July 2018; Published: 14 July 2018 Abstract: The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes. Keywords: chemistry; salt; water solubility; routes of administration; physicochemical; stability; degradation 1.
    [Show full text]
  • SALTS of FATTY ACIDS
    SALTS of FATTY ACIDS Prepared at the 33rd JECFA (1988), published in FNP 38 (1988) and in FNP 52 (1992). Metals and arsenic specifications revised at the 55th JECFA (2000). An ADI 'not specified' was established at the 33rd JECFA (1988) SYNONYMS INS No. 470 DEFINITION These products consist of calcium, potassium or sodium salts of commercial myristic, oleic, palmitic, stearic, acids or mixtures of these acids from edible fats and oils. The article of commerce can be further specified by: - saponification value, - solidification point for the fatty acids obtained from the salts, - iodine value, - residue on ignition including assay of the cation, and - moisture content Assay Not less than 95% total fatty acid salts, dry weight basis DESCRIPTION Hard, white or faintly yellowish, somewhat glossy and crystalline solids or semi-solids or white or yellowish-white powder FUNCTIONAL USES Anticaking agent, emulsifier CHARACTERISTICS IDENTIFICATION Solubility (Vol. 4) Potassium and sodium salts are soluble in water and ethanol; calcium salts are insoluble in water, ethanol and ether Test for cations Heat 1 g of the sample with a mixture of 25 ml of water and 5 ml of hydrochloric acid. Fatty acids are liberated, floating as a solid or oil layer on the surface which is soluble in hexane. After cooling, aqueous layer is decanted and evaporated to dryness. Dissolve the residue in water and test for the appropriate cation. Fatty acid composition Using the Method of Assay, identify the individual fatty sample. The fatty acid(s) in primary abundance should conform to those declared on the label of the product PURITY Free fatty acids Not more than 3% Measure free fatty acids as directed in the method Free Fatty Acids.
    [Show full text]
  • The Mechanism and Kinetics of Methyl Isobutyl Ketone Synthesis from Acetone Over Ion- Exchanged Hydroxyapatite
    Lawrence Berkeley National Laboratory Recent Work Title The mechanism and kinetics of methyl isobutyl ketone synthesis from acetone over ion- exchanged hydroxyapatite Permalink https://escholarship.org/uc/item/4hq4p42d Authors Ho, CR Zheng, S Shylesh, S et al. Publication Date 2018-09-01 DOI 10.1016/j.jcat.2018.07.005 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Journal of Catalysis 365 (2018) 174–183 Contents lists available at ScienceDirect Journal of Catalysis journal homepage: www.elsevier.com/locate/jcat The mechanism and kinetics of methyl isobutyl ketone synthesis from acetone over ion-exchanged hydroxyapatite ⇑ Christopher R. Ho a,b, Steven Zheng a, Sankaranarayanapillai Shylesh a,b, Alexis T. Bell a,b, a Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720-1462, United States b Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States article info abstract Article history: The synthesis of methyl isobutyl ketone (MIBK) can be carried out by the condensation of acetone in the Received 9 May 2018 presence of hydrogen over a supported metal catalyst. Previous studies have shown that hydroxyapatite Revised 26 June 2018 is an excellent catalyst for condensation reactions. The present investigation was undertaken in order to Accepted 2 July 2018 elucidate the reaction mechanism and site requirements for acetone coupling to MIBK over a physical Available online 18 July 2018 mixture of hydroxyapatite and Pd/SiO2. The reaction is found to proceed by consecutive aldol addition to form diacetone alcohol (DAA), dehydration of DAA to mesityl oxide (MO), and hydrogenation of MO Keywords: to MIBK.
    [Show full text]
  • 779 Part 770—Interpretations
    Pt. 770 15 CFR Ch. VII (1–1–21 Edition) in the item that qualitatively affect the per- roller bearings and parts). This applies formance of the U.S. and foreign items; to separate shipments of anti-friction (vi) Evidence of the interchangeability of bearings or bearing systems and anti- U.S. and foreign items; friction bearings or bearing systems (vii) Patent descriptions for the U.S. and foreign items; shipped with machinery or equipment (viii) Evidence that the U.S. and foreign for which they are intended to be used items meet a published industry, national, or as spares or replacement parts. international standard; (2) An anti-friction bearing or bear- (ix) A report or eyewitness account, by ing system physically incorporated in a deposition or otherwise, of the foreign item’s segment of a machine or in a complete operation; machine prior to shipment loses its (x) Evidence concerning the foreign manu- identity as a bearing. In this scenario, facturers’ corporate reputation; (xi) Comparison of the U.S. and foreign end the machine or segment of machinery item(s) made from a specific commodity, containing the bearing is the item sub- tool(s), device(s), or technical data; or ject to export control requirements. (xii) Evidence of the reputation of the for- (3) An anti-friction bearing or bear- eign item including, if possible, information ing system not incorporated in a seg- on maintenance, repair, performance, and ment of a machine prior to shipment, other pertinent factors. but shipped as a component of a com- plete unassembled (knocked-down) ma- SUPPLEMENT NO.
    [Show full text]
  • Methyl Isobutyl Ketone
    Issued: Data Sheet 19-Sep-2005 Product Name Methyl isobutyl ketone Product Code S1215 Asia Pacific Product Category Ketones CAS Registry 108-10-1 Number EINECS Number 203-550-1 Alternate Name 2-methyl-2-pentanone, hexanone, MIBK Description Methyl isobutyl ketone, MIBK, a medium boiling ketone is a stable water-white liquid. Like acetone and MEK, it displays strong solvent power for cellulose esters vinyl polymers and copolymers, and most natural and synthetic resins. MIBK is a medium evaporating solvent with excellent solvency characteristics and with a high tolerance for hydrocarbon diluents. Sales Property Unit Min Max Method Specification Purity % m/m 99.5 ASTM D3329 Water % m/m 0.05 ASTM D1364 Methyl isobutyl carbinol mg/kg 1000 ASTM D3329 Mesityloxide + mg/kg 1000 ASTM D3329 Isomesityloxide Dimethylketone mg/kg 1000 ASTM D3329 Appearance Cl & FFSM ASTM D4176 Color Pt-Co 10 ASTM D1209 Density @20°C g/mL 0.799 0.802 ASTM D4052 (4) Refractive Index @20°C 1.395 1.397 ASTM D1218 (4) Acidity as Acetic acid % m/m 0.005 ASTM D1613 Non Volatile Matter g/100mL 0.002 ASTM D1353 Distillation, IBP °C 114.0 ASTM D1078 (4) Distillation, DP °C 117.0 ASTM D1078 (4) (1) Guaranteed, (2) Typical, (3) Report Only, (4) Guaranteed spec with typical result Product as produced complies with DIN 53247, ASTM D 1153 and ACS 9th edition. Typical Properties Property Unit Method Value Density @20°C kg/L ASTM D4052 0.800 Cubic Expansion Coefficient @20°C (10^-4)/°C - 12 Refractive Index @20°C - ASTM D1218 1.396 Distillation, IBP °C ASTM D1078 114.0 Distillation,
    [Show full text]