USMPAKL00310919(1) AKLIEF Patient Brochure

You may pay as little as $0*†

LIGHTEN YOUR LOAD Patients† May pay as little as: Avoid wearing a backpack or sports equipment with $0 commercially unrestricted | $75 uninsured patients a chin strap or anything that rubs against your skin, Visit GaldermaCC.com/patients which can cause acne to ﬂ are. to download your savings card now.

*Certain limitations may apply. Visit Galdermacc.com/patients for program details. GUARD AGAINST THE SUN † Galderma CareConnect is only available for commercially insured or uninsured patients. You may have heard spending time in the sun can Patients who are enrolled in a government-run or government-sponsored healthcare plan with a pharmacy beneﬁ t are not eligible to use the Galderma CareConnect Patient help clear up skin but, in fact, sunlight may darken Savings Card. the appearance of acne and cause it to last longer. DON'T LET IMPORTANT SAFETY INFORMATION Be sure to ask your dermatology YOUR ACNE BE ® provider if you have any questions INDICATION: AKLIEF (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne THE FOCUS. about AKLIEF Cream. vulgaris in patients 9 years of age and older. ADVERSE EVENTS: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. WARNINGS/PRECAUTIONS: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided. You are encouraged to report negative side e ects of prescription drugs to the FDA. Visit www.fda.gov/ medwatch or call 1-800-FDA-1088. Reference: 1. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. ® J Am Acad Dermatol. 2019;80(6):1691-1699. INDICATION: AKLIEF (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. ADVERSE EVENTS: The most common adverse reactions (incidence ≥ 1%) in patients treated with ©2020 Galderma Laboratories, L.P. All Rights Reserved. All trademarks are the property of their respective owners. AKLIEF Cream were application site irritation, application site Galderma Laboratories, L.P., 14501 N. Freeway, Fort Worth, TX 76177 pruritus (itching), and sunburn. USMP/AKL/0031/0919(1) Printed in USA 1/20 Please see full Important Safety Information on the back page. Please see accompanying Brief Summary in the back pocket. VISIT AKLIEF COM TO LEARN MORE | 11 NO MORE SHYING AWAY FROM LIFE’S MOMENTS. TREATS ACNE BEYOND JUST YOUR FACE.1

If you’re feeling frustrated with your acne, you’re not alone. More than half of people with facial acne also have acne on their back, chest, or shoulders. Now, there’s something you can do about it.

Introducing AKLIEF® (trifarotene) Cream, 0.005%. Until now, no single topical acne treatment has been proven to be safe and e ective in treating acne on the face as well as on the chest, shoulders, and back.1

Take a moment to learn how AKLIEF Cream could treat your acne. And remember, speak with your dermatology provider if you have any questions.

INDICATION: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. ADVERSE EVENTS: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Please see full Important Safety Information on the back page. Please see accompanying Brief Summary in the back pocket.

VISIT AKLIEF COM TO LEARN MORE | 3 YOUR NEW APPROACH TO ACNE IS HERE. If you have been prescribed AKLIEF Cream and stay committed to it, you may be on the path to clearer skin. SEE RESULTS. Be sure to use as directed by your dermatology provider.

Actual patient from clinical study† Subject: BASELINE WEEK 12 5189-002 Age: 16 Gender: Female

THE LONG TERM STUDY: A multicenter, open-label study of 455 patients with moderate WEEK 26 WEEK 52 facial and truncal acne assessing the long-term safety (primary endpoint), e cacy, and quality of life (secondary endpoints) of AKLIEF Cream over 52 weeks.

In clinical trials, patients using AKLIEF® Cream INDICATION: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid achieved rapid results* on the face, chest, shoulders, indicated for the topical treatment of acne vulgaris in patients and back.1 But as with any treatment, results can vary 9 years of age and older. ADVERSE EVENTS: The most common from person to person. And sometimes, it can take adverse reactions (incidence ≥ 1%) in patients treated with months for your acne to clear up signiﬁ cantly. AKLIEF Cream were application site irritation, application site * Signiﬁ cant reduction in lesions as early as 2 weeks on the face and 4 weeks pruritus (itching), and sunburn. 1 on the chest, shoulders, back. Please see full Important Safety Information on the back page. † Study 18250: Open-label, single-arm, safety and e cacy 52-week trial of trifarotene cream. Please see accompanying Brief Summary in the back pocket.

VISIT AKLIEF COM TO LEARN MORE | 5 4 STEPS TO POSITIVE RESULTS follow this simple daily routine.

1. CLEANSE 3. MOISTURIZE Gently cleanse the area After applying AKLIEF to be treated with a mild Cream, moisturize your or soap-free cleanser skin with a product (such (such as Cetaphil® Gentle as Cetaphil® Moisturizing Skin Cleanser). Lotion) as often as needed to help minimize skin Avoid using skin products dryness and irritation. that may dry or irritate your skin.

2. APPLY 4. AVOID SUN Once skin is dry, apply Minimize your exposure a thin layer of AKLIEF® to sunlight. Use a sunscreen Cream to the a ected with SPF 15 or higher (such areas of the face or as Cetaphil® DermaControl chest, shoulders, and Oil Absorbing Moisturizer back once a day, with SPF 30), wear in the evening. Use protective clothing, and 1 pump for the face and a wide-brimmed hat to 2 pumps to cover back, cover treated areas. shoulders, and chest. Avoid using sunlamps, You can use an tanning beds, and ultra- additional pump to violet light during treatment cover middle or lower with AKLIEF Cream. back if needed.

VISIT AKLIEF COM TO LEARN MORE | 7 TARGET ACNE WITH YOUR NEW SECRET WEAPON: AKLIEF® Cream: TRIFAROTENE. A FEW THINGS TO KNOW.

PRECISE & SELECTIVE ■ Tell your HCP about all your medical conditions, The active ingredient in AKLIEF® Cream is including whether you’re pregnant or planning trifarotene, an innovative retinoid that speciﬁ cally on becoming pregnant targets the skin, to treat acne on the face, chest, ■ Avoid using AKLIEF Cream where you have cuts, 1 shoulders, and back. scrapes, eczema, or sunburned skin ■ You should avoid too much exposure to sunlight TREATING FROM ALL ANGLES and sunlamps. Use sunscreen or wear protective AKLIEF Cream starts to work quickly and is proven clothes including a wide-brimmed hat that to be e ective in treating acne on the face as well shades your face as on the chest, shoulders, and back.1 ■ You shouldn’t use AKLIEF Cream at the same time as products that irritate or dry your skin such as exfoliators, strong cleansers, and products containing high concentrations of alcohol

INDICATION: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid ■ You should avoid waxing the areas treated with indicated for the topical treatment of acne vulgaris in patients AKLIEF Cream 9 years of age and older. ADVERSE EVENTS: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Please see full Important Safety Information on the back page. Please see accompanying Brief Summary in the back pocket.

VISIT AKLIEF COM TO LEARN MORE | 9 GET CLOSER WITH CLEARER SKIN. You may pay some HELPFUL TIPS. as little as $0*†

about AKLIEF Cream. vulgaris in patients 9 years of age and older. ADVERSE EVENTS: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. WARNINGS/PRECAUTIONS: Patients using AKLIEF Cream may experience STAY FRESH erythema, scaling, dryness, and stinging/burning. Use When building up a sweat, avoid wearing tight a moisturizer from the initiation of treatment, and, if clothing, then try to shower and change clothes appropriate, depending upon the severity of these as soon as you can. adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or BE GENTLE eczematous or sunburned skin. Use of “waxing” as a Scrubbing skin clean may seem best, but it can depilatory method should be avoided on skin treated actually worsen acne-prone skin. Use a gentle with AKLIEF Cream. Minimize exposure to sunlight and cleanser and don’t scrub your skin. sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided. You are encouraged to report negative side e ects of prescription drugs to the FDA. Visit www.fda.gov/ INDICATION: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid medwatch or call 1-800-FDA-1088. indicated for the topical treatment of acne vulgaris in patients Reference: 1. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. ® 9 years of age and older. ADVERSE EVENTS: The most common J Am Acad Dermatol. 2019;80(6):1691-1699. INDICATION: AKLIEF (trifarotene) Cream, 0.005% is a retinoid adverse reactions (incidence ≥ 1%) in patients treated with indicated for the topical treatment of acne vulgaris in patients AKLIEF Cream were application site irritation, application site 9 years of age and older. ADVERSE EVENTS: The most common pruritus (itching), and sunburn. adverse reactions (incidence ≥ 1%) in patients treated with ©2020 Galderma Laboratories, L.P. All Rights Reserved. Please see full Important Safety Information on the back page. All trademarks are the property of their respective owners. AKLIEF Cream were application site irritation, application site Galderma Laboratories, L.P., 14501 N. Freeway, Fort Worth, TX 76177 pruritus (itching), and sunburn. Please see accompanying Brief Summary in the back pocket. USMP/AKL/0031/0919(1) Printed in USA 1/20 Please see full Important Safety Information on the back page. Please see accompanying Brief Summary in the back pocket. VISIT AKLIEF COM TO LEARN MORE | 11 You may pay as little as $0*†