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Relation Between Exercise Performance and Blood Storage Condition and Storage Time in Autologous Blood Doping
biology Review Relation between Exercise Performance and Blood Storage Condition and Storage Time in Autologous Blood Doping Benedikt Seeger and Marijke Grau * Molecular and Cellular Sports Medicine, German Sport University Cologne, 50677 Cologne, Germany; [email protected] * Correspondence: [email protected]; Tel.: +49-221-4982-6116 Simple Summary: Autologous blood doping (ABD) refers to sampling, storage, and re-infusion of one’s own blood to improve circulating red blood cell (RBC) mass and thus the oxygen transport and finally the performance capacity. This illegal technique employed by some athletes is still difficult to detect. Hence knowledge of the main effects of ABD is needed to develop valid detection methods. Performance enhancement related to ABD seems to be well documented in the literature, but applied study designs might affect the outcome that was analyzed herein. The majority of recent studies investigated the effect of cold blood storage at 4 ◦C, and only few studies focused on cryopreservation, although it might be suspected that cryopreservation is above all applied in sport. The storage duration—the time between blood sampling and re-infusion—varied in the reported literature. In most studies, storage duration might be too short to fully restore the RBC mass. It is thus concluded that most reported studies did not display common practice and that the reported performance outcome might be affected by these two variables. Thus, knowledge of the real effects of ABD, as applied in sport, on performance and associated parameters are needed to develop reliable detection techniques. Abstract: Professional athletes are expected to continuously improve their performance, and some might also use illegal methods—e.g., autologous blood doping (ABD)—to achieve improvements. -
A Legal Analysis of the WADA-Code Beyond the Contador Case
A legal analysis of the WADA-code beyond the Contador case Faculty: Tilburg Law School Department: Social Law and Social Politics Master: International and European Labour Law Author: Lonneke Zandberg Student number: 537776 Graduation date: March 14, 2012 Exam Committee: Prof. dr. M. Colucci Prof. dr. F.H.R. Hendrickx Table of contents: LIST OF ABBREVIATIONS ...................................................................................................................... 4 INTRODUCTION ........................................................................................................................ 5 1. HISTORY OF ANTI-DOPING .................................................................................................... 7 2. WADA .................................................................................................................................. 8 2.1 The arise of WADA .............................................................................................................. 8 2.2 World Anti Doping Code 2009 (WADA-code) ..................................................................... 8 2.3 The binding nature of the WADA-code ............................................................................. 10 2.4 Compliance and monitoring of the WADA-code .............................................................. 11 2.5 Sanctions for athletes after violating the WADA-code ..................................................... 12 3. HOW TO DEAL WITH A POSITIVE DOPING RESULT AFTER AN ATHLETE HAS EATEN CONTAMINATED -
Tdf 1996-2005.Pdf
Tour de France Top Overall Three Finishers Noting Anti-Doping Rule Violations and Allegations Year First Second Third 1996 Bjarne Riis on May 25, 2007 Riis issued a press release that he Jan Ullrich Implicated in Operación Puerto and was barred from the Richard Virenque On October 24, 2000, he admits in a also had made "mistakes" in the past, and in the following press 2006 Tour de France and fired by his T-Mobile team. He received a French court to doping knowingly but not willingly. The conference confessed to taking EPO, growth hormone and two-year suspension for Puerto involvement (8/22/11 – 8/21/13), Swiss cycling association suspended him for nine months cortisone for 5 years, from 1993 to 1998, including during his and results disqualified since 5/1/2005. victory in the 1996 Tour de France. 1997 Jan Ullrich Implicated in Operación Puerto and was barred from Richard Virenque On October 24, 2000, he admits in a French court Marco Pantani In the 1999 Giro d'Italia, he was expelled the 2006 Tour de France and fired by his T-Mobile team. He to doping knowingly but not willingly. The Swiss cycling association due to his irregular blood values. Although he was received a two-year suspension for Puerto involvement (8/22/11 suspended him for nine months disqualified for "health reasons", it was implied that – 8/21/13), and results disqualified since 5/1/2005. Pantani's high hematocrit was the product of EPO use. Later, it was revealed he had a hematocrit level of 60 per cent after his crash in 1995, above the later limit of 50. -
EL MUNDO Biografía No Autorizada De Alberto Contador (Solomillo
EL MUNDO Biografía no autorizada de Alberto Contador (solomillo incluido) 7/08/2017 Luis Fernando López Podría ocurrir: Alberto Contador, en su última carrera y en su último día, el próximo 10 de septiembre, sube al podio final de la Vuelta a España y el público le abuchea. Podría ocurrir, pero no va a ocurrir; no veremos a Contador sufrir una escena como las vividas estos días en el Mundial de atletismo, donde el público ha despreciado a Gatlin por su pasado de dopaje con recurrentes pitadas (el silencio a veces es más sonoro). No es el público español más respetuoso que el inglés, no, pues también aquí gusta mucho silbar; basta repasar las finales de Copa del Rey, el cariño que una parte de la grada le dispensa a Piqué cuando acude con la selección o algunas sinfonías antes de partidos de La Roja (oé, oé). Pero a Contador no se le pitará. Madrid/España no es Londres. Y bien está. Pero, ¿le aplaudimos como si nada? Más preguntas: ¿Tiene derecho al perdón quien se ha dopado? Si somos capaces de 'olvidar' crímenes u ofensas mayores, ¿por qué no íbamos a hacerlo con un deportista que se equivocó/nos engañó una vez? Pero, claro, depende. ¿Cuántas veces se equivocó y nos engañó Contador? Una noche de julio de 2006, apenas un mes después de ser detenido en la 'operación Puerto' como cabecilla de una trama de dopaje, Eufemiano Fuentes, un 'teórico' de las autotransfusiones con EPO, acudió a 'El Larguero' para explicarse, al fin. De lo que dijo, a quien esto escribe, que es periodista pero no de los especializados en ciclismo, le sorprendió algo. -
Blood Doping - a Literature Review*
Br. J. Sp. Med; Vol 23 Review Br J Sports Med: first published as 10.1136/bjsm.23.2.84 on 1 June 1989. Downloaded from Blood doping - a literature review* Mark Jones' MB, BS, Dip Sports Med and Dan S Tunstall Pedoe2 DPhil, FRCP There is increasing evidence that the technique of reinfus- Heterologous blood doping involves the infusion of blood ing an athlete's stored blood prior to competition to im- from one or more cross-matched donors. prove performance has been used on many occasions. Although early experimental results were controversial and the precise mechanism by which the technique improves Techniques of blood doping performance is still debated, there is now strong evidence that if the blood doping produces a sufficient rise in total red cell mass there are significant improvements in Heterologous blood doping physiological variables such as maximum oxygen uptake, Use of a matched blood donor has the advantage that lactate buffering and thermoregulation. These physiologi- the athlete does not have to suffer the detraining ef- cal changes are matched by improvements in endurance fects of venesection. The blood can be used im- performance. These may persist in diminishing degree for mediately and, if so, has not suffered any deleterious several weeks, but have to be weighed against the detrain- ing effect produced by the repeated venesection required to effects from storage. The disadvantages are the poten- obtain an adequate amount of stored blood for autologous tial transfer of infection, such as hepatitis and AIDS, reinfusion. and possibilities of transfusion reactions. Heterolog- Experimental evidence suggests that the transient in- ous blood transfusion or packing is also easier to detect crease in blood volume and cardiac output following rein- with an appropriate blood sample. -
Ranking the Greatest Cyclists of All Time
The Outer Line The External Perspective On Pro Cycling Rankinghttps://www.theouterline.com The Greatest Cyclists Of All Time Who are the greatest male cyclists of all time? That would make a good trivia question at the cycling club’s annual dinner, and it’s sure to provide fodder for unending debate. Think about it: How many of us in America know enough cycling history to even come up with five good names? Sure, you could list the men who have won five Tours de France: Anquetil, Merckx, Hinault, and Induráin. (I’m omitting Armstrong, whose seven victories were officially annulled.) But that’s only four names. And Le Tour, of course, is only one race. Most of us don’t know our cycling like we know our baseball. Any baseball fan past infancy knows the names Ruth and Gehrig, Mantle and Mays, Clemens and Bonds. But American cycling fans would be hard- pressed, I think, to remember — let alone spell — the names Joop Zoetemelk and Roger de Vlaeminck. Both of those men, as it turns out, probably belong on any list of all-time greats. Zoetemelk was a Dutch ironman who started and finished the Tour 16 times (and won it once). De Vlaeminck was a Belgian steam engine who won the brutal Paris-Roubaix four times, the marathon Milano-Sanremo three times, and Tirreno-Adriatico, the Race of the Two Seas, six times. I know all of this thanks to CyclingRanking.com, a well-researched and well-documented site that attempts to list, in order, the greatest professional men’s cyclists of all time.The site is a labor of love by a Dutch family that started out as a kitchen-table exercise in the 1970s, and it will humble even the most studious cycling fans. -
Dimeo and Henning Final.Pdf
This is an Accepted Manuscript of a chapter published by Taylor & Francis Group in Fincoeur B, Gleaves J & Ohl F (eds.) Doping in Cycling: Interdisciplinary Perspectives. Ethics and Sport. Doping in Cycling: Interdisciplinary Perspectives: Routledge, pp. 177-188. https://www.routledge.com/Doping-in-Cycling-Interdisciplinary-Perspectives-1st- Edition/Fincoeur-Gleaves-Ohl/p/book/9781138477902 The Decline of Trust in British Sport since the London Olympics: Team Sky’s Fall from Grace Paul Dimeo and April Henning Abstract The success of Team Sky has been over-shadowed by a range of allegations and controversies, leaving significant doubts around their much-vaunted pro anti-doping stance. This chapter aims to contextualise these doubts within the wider frame of British sport, and more specifically the decline of trust. We trace the emergence of Team Sky from the National Lottery funded track team, arguing that the London Olympics was a pinnacle of medal-winning and public admiration. The turn towards professional road cycling was accompanied by new approaches to medicalisation. The Fancy Bears hack of WADA’s database, whistle-blower insights, Government inquiries, and media scrutiny have presented the public with sufficient evidence and critique to undermine the reputation of Team Sky’s management and riders. Other factors have contributed to the decline of trust, not least evidence of doping from the Russia investigations, the leaked IAAF blood files, the role of the IAAF senior managers, the conflict between WADA and the IOC over banning Russian athletes, and other related debates. We argue that the high-profile debate over the use of drugs in British professional cycling can be understood as symptomatic of a wider malaise affecting British sport, which in turn can be contextualised, explained, and seen as part of a broader shift in scepticism regarding political leaders and media organisations. -
A Fool's Game: Blood Doping in Sport
Performance Enhancement & Health 3 (2014) 54–58 Contents lists available at ScienceDirect Performance Enhancement & Health j ournal homepage: www.elsevier.com/locate/peh A fool’s game: Blood doping in sport a,b,∗ c Cindy R. Towns , David F. Gerrard a Dunedin Hospital, 201 Great King St, Dunedin 9016, New Zealand b University of Otago Bioethics Centre, Dunedin, New Zealand c Dunedin School of Medicine, University of Otago, New Zealand a r t i c l e i n f o a b s t r a c t Article history: ‘Blood doping’ involves the transfusion of blood into an athlete’s circulation to boost their oxygen carrying Received 27 March 2014 capacity. The procedure has been used in endurance events such as cycling and skiing but is prohibited by Received in revised form 7 November 2014 the World Anti-Doping Agency. The validity of restrictions on performance enhancement including ‘blood Accepted 10 November 2014 doping’ has been challenged. However, the argument for legalisation fails to recognise the significant risks Available online 4 December 2014 inherent to the use of blood products that include: immune reaction, bacterial contamination and the transmission of viral disease. The argument also fails to recognise the disparities in health resources that Keywords: would render athletes from less wealthy nations at much greater risk. There are significant, health risks Doping in sports associated with blood doping; this seriously compromises claims for legalisation. Blood doping Ethics © 2014 Elsevier Ltd. All rights reserved. 1. Introduction received a suspended jail sentence for providing transfusions to athletes in 2013 (Staunton, 2013). -
Fuentes Rodriguez (“Fuentes”) in Spanish Investigation*
OVERVIEW OF EVIDENCE OF RIDERS CONNECTED TO EUFEMIANO FUENTES RODRIGUEZ (“FUENTES”) IN SPANISH INVESTIGATION* Rider Team Notes Source Roberto Heras Liberty Seguros-Würth Doping schedule for EPO, GH, IGF-1, anabolics, June 27, 2006 Official Letter from Spanish Ministry of the Interior’s Environment and blood transfusions Consumption Civil Guard (“Civil Guard”) to the Magistrate of the Madrid Local Handwritten notes with dates of EPO, Epocrin, IGF- Criminal Court (“Investigation Memorandum”), at pp. 12, 14, 28,29,30, 31, 32 1, GH, and transfusions March 26, 2002 note referencing payment and EPO info September 9, 2005 delivery package note referencing Heras’ and Fuentes’ address Marcos Serrano- Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, at pp. 18, 28, 30 (formerly with Blood transfusion records Comunidad 2005 Payment records Valenciana-Kelme) Angel Vicioso- Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, pp. 18, 28, 30 (formerly with Blood transfusion records Comunidad 2005 Payment records Valenciana-Kelme) Dariuz Baranowsky Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, p. 30 Joseba Beloki Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, pp. 18, 30 2005 Payment records David Etxebarria Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, pp. 18, 30 2005 Payment records Nuno Ribeiro Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, p. 30 *This chart is not exhaustive as other riders were implicated in the investigation. See Civil Investigation Memo attached at Appendix M. 1 OVERVIEW OF EVIDENCE OF RIDERS CONNECTED TO EUFEMIANO FUENTES RODRIGUEZ (“FUENTES”) IN SPANISH INVESTIGATION* Luis Leon Sanchez Liberty Seguros-Würth 2005 Liberty team calendars Investigation Memorandum, p. -
Blood Doping, Erythropoietin and Altitude
© 1997 Elsevier Science B. V. AU rights reserved. The Clinical Pharmacology of Sport and Exercise 199 T. Keilly and M. Orme, editors Blood Doping, Erythropoietin and Altitude Bjorn Ekblom Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden Key words: Doping, erythropoietin, exercise, haemoglobin, physical performance. 1. INTRODUCTION Physical performance in sport is determined by biomechanical, physiological, psychological and other factors. Maximal aerobic power, anaerobic capacity, aerobic/anaerobic metabolic efficiency, muscle strength and co-ordination are the most important ones. Their relative importance depends on the individual demands within different sports. Nowadays the differences in these parameters between world class athletes in a specific sport are fairly small. Minor changes in any of these physiological factors, due to internal or external influences, can help explain and cause important changes in physical performance and, thus, success in sport. In this context the energy turn-over during exercise is without doubt'of utmost interest. It is fairly well-known that changes in energy expenditure can have a great influence on competitive results. Over the years athletes have searched for both legal and illegal methods and substances to help increase maximal aerobic power, anaerobic capacity, or metabolic efficiency during severe exercise, thus improving their physical performance. The following discussion concerns some of the factors that influence energy yield during exercise. 2. EFFECT OF HYPOXIA Reduction of arterial oxygen content, whether it is a consequence of or through anaemia or different types of hypoxia, causes a reduction in physical performance and can induce many different physiological reactions. It is evident that a stay at altitude (hypobaric hypoxia) causes a reduction in maximal aerobic power and physical performance. -
Blood Doping As an Ergogenic Aid SUMMARY
American College of Sports Medicine Position Stand on Blood Doping as an Ergogenic Aid SUMMARY While reports of blood doping for scientific purposes appeared as early as 1947 (23), it was not until the 1976 Blood doping is an ergogenic* procedure wherein Olympic Games in Montreal that it was suggested the nomtovolemic erythrocythemia is induced via autolo- procedure had been used as an ergogenic aid for endur- gous (i.e., re-infusion of athlete's own blood) or homol- ance events (11, 34). Since that time, both athletes and ogous (Le., transfusion of type matched donor's blood) sports officials have publicly admitted having employed red blood cell (RBC) infusion (11, 27, 28, 34). The homologous RBC infusion as an ergogenic aid during resultant hemoconcentration increases arterial oxygen international competition. These actions prompted a concentration (CaO ) (9, 23). During peak exercise, 2 call for an unequivocal statement regarding the ergo- oxygen delivery [cardiac output (Q)xCaO2] to skeletal genie, physiological, medical, and ethical implications muscle is enhanced, improving maximal oxygen uptake underlying the use of blood doping as an ergogenic aid. (VOzma) and endurance capacity (9, 28,29, 31). Such This position statement was prepared by the Ameri- terms as blood boosting, blood packing, and induced can College of Sports Medicine in response to these erythrocythemia are also variously used to describe this concerns. ergogenic procedure (11, 34). It is the position of the American College of Sports Medicine that the use of blood doping as an ergogenic ERGOGENIC EFFECT i aid for athletic competition is unethical and unjustifi- able, but that autologous RBC infusion is an acceptable The ergogenic properties of normovolemic erythro- procedure to induce erythrocythemia in clinically con- cythemia have, in part, been inferred from the increase trolled conditions for the purpose of legitimate scientific in oxygen transport capacity that attends prolonged inquiry. -
BIOCHEMISTRY, PHYSIOLOGY, and COMPLICATIONS of BLOOD DOPING: Facts and Speculation
BIOCHEMISTRY, PHYSIOLOGY, AND COMPLICATIONS OF BLOOD DOPING: Facts and Speculation QUERY SHEET Q1: Au: Ok to key reference in text. Q2: Au: Must perflubron be capped (see three paragraph down)? Q3: Au: Line style for perflubron does not match key. Q4: Au: Ref. 50 should “s” precede page nos. Q5: Au: Ref. 18 should “s” precede page nos. Q6: Au: Ref. 75. Check style for page nos. Q7: Au: Pls. varify page nos. Q8: Au: Check page range. Q9: Au: Should a supplement number be given. Q10: Au: Supplement number? Q11: Au: Supplement number? Q12: Au: Supplement number? Q13: Au: Supplement number? Q14: Au: Check page range. Critical Reviews in Clinical Laboratory Sciences, 43(4):349–391 (2006) Copyright C 2006 Taylor & Francis Group, LLC ISSN: 1040-8363 print / 1549-781X online DOI: 10.1080/10408360600755313 1 BIOCHEMISTRY, PHYSIOLOGY, AND COMPLICATIONS OF BLOOD 2 DOPING: Facts and Speculation 3 Giuseppe Lippi 2 Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze 4 Morfologico-Biomediche, Universita` degli Studi di Verona, Verona, Italy 5 Massimo Franchini 2 Servizio di Immunoematologia e Trasfusione, Azienda 6 Ospedaliera di Verona, Verona, Italy 7 Gian Luca Salvagno and Gian Cesare Guidi 2 Istituto di Chimica e Microscopia 8 Clinica, Dipartimento di Scienze Morfologico-Biomediche, Universita` degli Studi di Verona, 9 Verona, Italy 10 Referee Dr. S.G. Sandler, Georgetown University Medical Center, Washington, DC, 11 USA 12 2 Competition is a natural part of human nature. Techniques and substances employed to enhance 13 athletic performance and to achieve unfair success in sport have a long history, and there has been 14 little knowledge or acceptance of potential harmful effects.