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The Fourth Paradigm
ABOUT THE FOURTH PARADIGM This book presents the first broad look at the rapidly emerging field of data- THE FOUR intensive science, with the goal of influencing the worldwide scientific and com- puting research communities and inspiring the next generation of scientists. Increasingly, scientific breakthroughs will be powered by advanced computing capabilities that help researchers manipulate and explore massive datasets. The speed at which any given scientific discipline advances will depend on how well its researchers collaborate with one another, and with technologists, in areas of eScience such as databases, workflow management, visualization, and cloud- computing technologies. This collection of essays expands on the vision of pio- T neering computer scientist Jim Gray for a new, fourth paradigm of discovery based H PARADIGM on data-intensive science and offers insights into how it can be fully realized. “The impact of Jim Gray’s thinking is continuing to get people to think in a new way about how data and software are redefining what it means to do science.” —Bill GaTES “I often tell people working in eScience that they aren’t in this field because they are visionaries or super-intelligent—it’s because they care about science The and they are alive now. It is about technology changing the world, and science taking advantage of it, to do more and do better.” —RhyS FRANCIS, AUSTRALIAN eRESEARCH INFRASTRUCTURE COUNCIL F OURTH “One of the greatest challenges for 21st-century science is how we respond to this new era of data-intensive -
School of Forestry & Environmental Studies 2015–2016
BULLETIN OF YALE UNIVERSITY BULLETIN OF YALE BULLETIN OF YALE UNIVERSITY Periodicals postage paid New Haven ct 06520-8227 New Haven, Connecticut School of Forestry & Environmental Studies 2015–2016 School of Studies & Environmental Forestry 2015–2016 BULLETIN OF YALE UNIVERSITY Series 111 Number 12 August 20, 2015 BULLETIN OF YALE UNIVERSITY Series 111 Number 12 August 20, 2015 (USPS 078-500) The University is committed to basing judgments concerning the admission, education, is published seventeen times a year (one time in May and October; three times in June and employment of individuals upon their qualifications and abilities and a∞rmatively and September; four times in July; five times in August) by Yale University, 2 Whitney seeks to attract to its faculty, sta≠, and student body qualified persons of diverse back- Avenue, New Haven CT 0651o. Periodicals postage paid at New Haven, Connecticut. grounds. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against Postmaster: Send address changes to Bulletin of Yale University, any individual on account of that individual’s sex, race, color, religion, age, disability, PO Box 208227, New Haven CT 06520-8227 status as a protected veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression. Managing Editor: Kimberly M. Go≠-Crews University policy is committed to a∞rmative action under law in employment of Editor: Lesley K. Baier women, minority group members, individuals with disabilities, and protected veterans. PO Box 208230, New Haven CT 06520-8230 Inquiries concerning these policies may be referred to Valarie Stanley, Director of the O∞ce for Equal Opportunity Programs, 221 Whitney Avenue, 3rd Floor, 203.432.0849. -
Molecular Mechanisms Regulating Complement Receptor 3-Mediated
University of Massachusetts Amherst ScholarWorks@UMass Amherst Open Access Dissertations 9-2012 Molecular mechanisms regulating Complement Receptor 3-mediated phagocytosis of Borrelia burgdorferi Kelly Lynn Hawley University of Massachusetts Amherst, [email protected] Follow this and additional works at: https://scholarworks.umass.edu/open_access_dissertations Part of the Biotechnology Commons Recommended Citation Hawley, Kelly Lynn, "Molecular mechanisms regulating Complement Receptor 3-mediated phagocytosis of Borrelia burgdorferi" (2012). Open Access Dissertations. 645. https://doi.org/10.7275/sa1d-j556 https://scholarworks.umass.edu/open_access_dissertations/645 This Open Access Dissertation is brought to you for free and open access by ScholarWorks@UMass Amherst. It has been accepted for inclusion in Open Access Dissertations by an authorized administrator of ScholarWorks@UMass Amherst. For more information, please contact [email protected]. MOLECULAR MECHANISMS REGULATING COMPLEMENT RECEPTOR 3- MEDIATED PHAGOCYTOSIS OF BORRELIA BURGDORFERI A Dissertation Presented by KELLY L. HAWLEY Submitted to the Graduate School of the University of Massachusetts Amherst in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY September 2012 Department of Animal Biotechnology and Biomedical Sciences © Copyright by Kelly L. Hawley 2012 All rights Reserved MOLECULAR MECHANISMS REGULATING COMPLEMENT RECEPTOR 3- MEDIATED PHAGOCYTOSIS OF BORRELIA BURGDORFERI A Dissertation Presented by KELLY L. HAWLEY Approved -
Profile on Environmental and Social Considerations in Philippines
Profile on Environmental and Social Considerations in Philippines ANNEX September 2011 Japan International Cooperation Agency (JICA) CRE CR(5) 11-014 Table of Contents IUCN Red List of the Philippines (2007) Red List of the Philippine Red Data Book,1997 Threatened Species by the National Laws Philippine Fauna and Flora under CITES APPENDIX, 2011 Protected Areas under the NIPAS Act in the Philippines (as of June, 2011) Environmental Standards CDM Projects in the Philippines (as of March 31, 2011) Project Grouping Matrix for Determination of EIA Report Type EIA Coverage & Requirements Screening Checklists Outlines of Required Documents by PEISS IUCN Red List of the Philippines ,2007 IUCN Red List of the Philippines (2007) # Scientific Name Common Name Category Mammals 1 Acerodon jubatus GOLDEN-CAPPED FRUIT BAT EN 2 Acerodon leucotis PALAWAN FRUIT BAT VU 3 Alionycteris paucidentata MINDANAO PYGMY FRUIT BAT VU 4 Anonymomys mindorensis MINDORO CLIMBING RAT VU 5 Apomys sacobianus LONG-NOSED LUZON FOREST MOUSE VU 6 Apomys gracilirostris LARGE MINDORO FOREST MOUSE VU 7 Archboldomys luzonensis MT ISAROG SHREW-MOUSE EN 8 Axis calamianensis CALAMANIAN DEER EN 9 Bubalus mindorensis MINDORO DWARF BUFFALO CR 10 Cervus alfredi PHILLIPINE SPOTTED DEER EN 11 Chrotomys gonzalesi ISAROG STRIPED SHREW-RAT, CR 12 Chrotomys whiteheadi LUZON STRIPED RAT VU 13 Crateromys australis DINAGAT BUSHY-TAILED CLOUD RAT EN 14 Crateromys schadenbergi GIANT BUSHY-TAILED CLOUD RAT VU 15 Crateromys paulus OILIN BUSHY-TAILED CLOUD RAT CR 16 Crateromys heaneyi PANAY BUSHY-TAILED -
Biodiversity Baseline Assessment in the REDD-Plus Pilot and Key Biodiversity Area in Mt
Biodiversity baseline assessment in the REDD-Plus pilot and key biodiversity area in Mt. Nacolod, Southern Leyte Final technical report in collaboration with Imprint This publication is by the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH through the Climate-relevant Modernization of the National Forest Policy and Piloting of Reducing Emissions from Deforestation and Forest Degradation (REDD) Measures Project in the Philippines, funded by the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) under its International Climate Initiative. The BMU supports this Initiative based on a decision of the German Parliament. For more information, see http://www.international-climate-initiative.com. As a federally owned enterprise, GIZ supports the German Government in achieving its objectives in the field of international cooperation for sustainable development. This study was undertaken by Fauna & Flora International commissioned by GIZ, with co-financing by the United Nations Development Programme (UNDP)- Global Environmental Facility (GEF)-DENR Biodiversity Management Bureau (BMB) New Conservation Areas in the Philippines Project (NewCAPP) and the Foundation for the Philippine Environment (FPE). Statements from named contributors do not necessarily reflect the views of the publisher. Data and information generated from the study are within the possession of the Philippine Government through the DENR as mandated by law. Published by Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH Registered offices Bonn and Eschborn, Germany T +49 228 44 60-0 (Bonn) T +49 61 96 79-0 (Eschborn) Responsible For. Ricardo L. Calderon Director Department of Environment and Natural Resources-Forest Management Bureau Forest Management Bureau Building Visayas Avenue, Quezon City 1101 Philippines T: 63 2 928 9313 / 927 4788 F: 63 2 920 0374 Dr. -
Technologies of Pandemic Control: Privacy and Ethics for COVID-19 Surveillance // 2
TECHNOLOGIES OF PANDEMIC CONTROL // Privacy and Ethics for COVID-19 Surveillance S.E. Freeman October 2020 Technologies of Pandemic Control // Privacy and Ethics for COVID-19 Surveillance S.E. Freeman October 2020 Contents Executive Summary 1 01 // INTRODUCTION 3 02 // TECHNOLOGICAL INTERVENTIONS 7 EXPOSURE NOTIFICATION AND DIGITAL PROXIMITY TRACING 8 How does it work? 9 Why use these interventions? 12 What concerns are raised? 13 Questionable effectiveness 13 Data could be re-identified 17 Could exacerbate existing inequalities 19 What requirements are needed to protect user privacy? 22 AGGREGATED LOCATION DATA 25 How does it work? 25 Why use this intervention? 26 What concerns are raised? 27 What requirements are needed to protect user privacy? 29 SYMPTOM-TRACKING APPLICATIONS 30 How does it work? 31 Why use this intervention? 32 What concerns are raised? 33 What requirements are needed to protect user privacy? 33 IMMUNITY PASSPORTS 34 How does it work? 34 Why use this intervention? 35 What concerns are raised? 35 What requirements are needed to protect user privacy? 38 03 // EXISTING REGULATORY FRAMEWORKS 40 APPLICABLE U.S. DATA PRIVACY REGULATIONS: A SNAPSHOT 41 FEDERAL LEGISLATION INTRODUCED FOR COVID-19 DATA 44 04 // CONCLUSIONS 47 05 // RECOMMENDATIONS 51 ACKNOWLEDGMENTS 56 ADDITIONAL RESOURCES 57 ABOUT THE CITRIS POLICY LAB & THE HUMAN RIGHTS CENTER 60 Executive Summary In response to the rapid spread of COVID-19 and its devastating effect on communities across the United States, private companies, state and local governments, nonprofits, and epidemiologists have been harnessing the powers of big data and technology in an attempt to better understand and contain the spread of the virus. -
ENVIRONMENTAL STUDIES FALL 2008 Environment YALE
THE JOURNAL OF THE SCHOOL OF FORESTRY & ENVIRONMENTAL STUDIES FALL 2008 environment YALE Chinese Cities Shaping Their Climate By Christina Larson page 12 Global Warming Focus of New Fund By Jon Luoma page 16 Wall Street’s CARBON CONVERSION By Richard Conniff letters To the Editor: These questions will force manufacturers in ufactured goods, the United States has a Since the publication of your excellent China, Indonesia and elsewhere to identify the considerable ability to improve not just the article, “Forest Destruction’s Prime Suspect” scientific name of any species used and the global wood trade but illegal practices in (environment: Yale, Spring 2008), the United country of original harvest, introducing a vital mining, fishing and other resource extraction States has become the first country in the new level of transparency to supply chains. industries as well. This could be the first in world to ban the import and sale of illegally Companies and individuals can be pros- a line of measures that uses U.S. consumer harvested wood. ecuted under the law if the government can power to improve global natural resource In response to pressure from a diverse prove that they knowingly traded in illegal management. coalition of environmental, industrial and wood or were negligent in not knowing The Environmental Investigation Agency labor groups, the Bush administration passed that their supply was illegal. Any shipment led the diverse coalition that supported this a ground-breaking law in May banning com- of wood can be seized if the government can bill’s passage, and we continue to work closely merce in illegally sourced plants and their prove that it was illegally harvested or traded, with forest industry and nongovernmental products, including timber and wood products. -
San Bernardino County Adds New Vaccination Locations; Walk-Ups Will Be Accepted | News | Fontanaheraldnews.Com
5/3/2021 San Bernardino County adds new vaccination locations; walk-ups will be accepted | News | fontanaheraldnews.com https://www.fontanaheraldnews.com/news/san-bernardino-county-adds-new-vaccination-locations-walk- ups-will-be-accepted/article_b08222c4-ab93-11eb-abe4-db0c2de613.html FEATURED San Bernardino County adds new vaccination locations; walk-ups will be accepted May 2, 2021 San Bernardino County In an effort to get as many people as possible vaccinated for the coronavirus, San Bernardino County continues to add new locations that can be accessed easily. Beginning May 4, “Operation Flip” is converting ve existing testing sites into new vaccination locations in the county. https://www.fontanaheraldnews.com/news/san-bernardino-county-adds-new-vaccination-locations-walk-ups-will-be-accepted/article_b08222c4-ab93-1… 1/3 5/3/2021 San Bernardino County adds new vaccination locations; walk-ups will be accepted | News | fontanaheraldnews.com The converted testing sites in Montclair, Rancho Cucamonga, and San Bernardino will allow residents to access ongoing sites in everyday locations where they may already be shopping, attending school or running errands. Two additional sites in Adelanto and Rialto are open only for a limited time. And while appointments are always encouraged, walk-ups to county-operated sites are now welcome too. The Operation Flip sites begin on Tuesday, May 4 at the following locations and times. The Pzer vaccine will be offered at ongoing sites, while the one-day Rialto and one-week Adelanto events will be offering the “one and done” Johnson & Johnson vaccine: ----- Montclair Place (5060 E North Montclair Plaza Lane, Montclair) -- Register or walk-up anytime, Tuesday through Saturday, 10 a.m. -
Detailed Species Accounts from The
Threatened Birds of Asia: The BirdLife International Red Data Book Editors N. J. COLLAR (Editor-in-chief), A. V. ANDREEV, S. CHAN, M. J. CROSBY, S. SUBRAMANYA and J. A. TOBIAS Maps by RUDYANTO and M. J. CROSBY Principal compilers and data contributors ■ BANGLADESH P. Thompson ■ BHUTAN R. Pradhan; C. Inskipp, T. Inskipp ■ CAMBODIA Sun Hean; C. M. Poole ■ CHINA ■ MAINLAND CHINA Zheng Guangmei; Ding Changqing, Gao Wei, Gao Yuren, Li Fulai, Liu Naifa, Ma Zhijun, the late Tan Yaokuang, Wang Qishan, Xu Weishu, Yang Lan, Yu Zhiwei, Zhang Zhengwang. ■ HONG KONG Hong Kong Bird Watching Society (BirdLife Affiliate); H. F. Cheung; F. N. Y. Lock, C. K. W. Ma, Y. T. Yu. ■ TAIWAN Wild Bird Federation of Taiwan (BirdLife Partner); L. Liu Severinghaus; Chang Chin-lung, Chiang Ming-liang, Fang Woei-horng, Ho Yi-hsian, Hwang Kwang-yin, Lin Wei-yuan, Lin Wen-horn, Lo Hung-ren, Sha Chian-chung, Yau Cheng-teh. ■ INDIA Bombay Natural History Society (BirdLife Partner Designate) and Sálim Ali Centre for Ornithology and Natural History; L. Vijayan and V. S. Vijayan; S. Balachandran, R. Bhargava, P. C. Bhattacharjee, S. Bhupathy, A. Chaudhury, P. Gole, S. A. Hussain, R. Kaul, U. Lachungpa, R. Naroji, S. Pandey, A. Pittie, V. Prakash, A. Rahmani, P. Saikia, R. Sankaran, P. Singh, R. Sugathan, Zafar-ul Islam ■ INDONESIA BirdLife International Indonesia Country Programme; Ria Saryanthi; D. Agista, S. van Balen, Y. Cahyadin, R. F. A. Grimmett, F. R. Lambert, M. Poulsen, Rudyanto, I. Setiawan, C. Trainor ■ JAPAN Wild Bird Society of Japan (BirdLife Partner); Y. Fujimaki; Y. Kanai, H. -
List of Taxa for Which MIL Has Images
LIST OF 27 ORDERS, 163 FAMILIES, 887 GENERA, AND 2064 SPECIES IN MAMMAL IMAGES LIBRARY 31 JULY 2021 AFROSORICIDA (9 genera, 12 species) CHRYSOCHLORIDAE - golden moles 1. Amblysomus hottentotus - Hottentot Golden Mole 2. Chrysospalax villosus - Rough-haired Golden Mole 3. Eremitalpa granti - Grant’s Golden Mole TENRECIDAE - tenrecs 1. Echinops telfairi - Lesser Hedgehog Tenrec 2. Hemicentetes semispinosus - Lowland Streaked Tenrec 3. Microgale cf. longicaudata - Lesser Long-tailed Shrew Tenrec 4. Microgale cowani - Cowan’s Shrew Tenrec 5. Microgale mergulus - Web-footed Tenrec 6. Nesogale cf. talazaci - Talazac’s Shrew Tenrec 7. Nesogale dobsoni - Dobson’s Shrew Tenrec 8. Setifer setosus - Greater Hedgehog Tenrec 9. Tenrec ecaudatus - Tailless Tenrec ARTIODACTYLA (127 genera, 308 species) ANTILOCAPRIDAE - pronghorns Antilocapra americana - Pronghorn BALAENIDAE - bowheads and right whales 1. Balaena mysticetus – Bowhead Whale 2. Eubalaena australis - Southern Right Whale 3. Eubalaena glacialis – North Atlantic Right Whale 4. Eubalaena japonica - North Pacific Right Whale BALAENOPTERIDAE -rorqual whales 1. Balaenoptera acutorostrata – Common Minke Whale 2. Balaenoptera borealis - Sei Whale 3. Balaenoptera brydei – Bryde’s Whale 4. Balaenoptera musculus - Blue Whale 5. Balaenoptera physalus - Fin Whale 6. Balaenoptera ricei - Rice’s Whale 7. Eschrichtius robustus - Gray Whale 8. Megaptera novaeangliae - Humpback Whale BOVIDAE (54 genera) - cattle, sheep, goats, and antelopes 1. Addax nasomaculatus - Addax 2. Aepyceros melampus - Common Impala 3. Aepyceros petersi - Black-faced Impala 4. Alcelaphus caama - Red Hartebeest 5. Alcelaphus cokii - Kongoni (Coke’s Hartebeest) 6. Alcelaphus lelwel - Lelwel Hartebeest 7. Alcelaphus swaynei - Swayne’s Hartebeest 8. Ammelaphus australis - Southern Lesser Kudu 9. Ammelaphus imberbis - Northern Lesser Kudu 10. Ammodorcas clarkei - Dibatag 11. Ammotragus lervia - Aoudad (Barbary Sheep) 12. -
The Pandemic Information Solution: Overcoming the Brutal Economics of Covid-19
THE PANDEMIC INFORMATION SOLUTION INFORMATION THE PANDEMIC THE PANDEMIC INFORMATION SOLUTION Overcoming the Brutal Economics of Covid-19 THE Joshua Gans Covid-19 is a global pandemic inflicting large health and economic costs. PANDEMIC In The Pandemic Information Gap: The Brutal Economics of COVID-19 (MIT Press, 2020), economist Joshua Gans explains that those costs have been so large because governments and others have lacked the information to control the pandemic. Unless we know who is infectious, we can’t break the chains of INFORMATION transmission, and that results in the escalation of our problems. Pandemics, he writes, are information problems. Now, in this follow-up book, Gans outlines the solution to the information SOLUTION gap. By engaging in rapid, frequent screening, we can control the pandemic OVERCOMING THE BRUTAL ECONOMICS OF COVID-19 OVERCOMING THE BRUTAL and restore normality. We can lower the number of cases, break chains of transmission, and make it safe for people to interact again. This will require changing our mindset about testing, gathering the right information, and matching that information to the right decisions. We have the ingredients to do all these things. We just need to put them together in a scalable and sustainable system. This book is a guide to the issues and trade-offs that policymakers and other key decision-makers need to grapple with and follow. OVERCOMING Joshua Gans is a professor of strategic management Praise for Economics in the Age of COVID-19 and the Jeffrey S. Skoll Chair in Technical Innovation and Entrepreneurship at the University of Toronto’s “It’s a shame that policymakers did not Rotman School of Management. -
Genomics and Conservation Genetics
Review TRENDS in Ecology and Evolution Vol.21 No.11 Genomics and conservation genetics Michael H. Kohn1, William J. Murphy2, Elaine A. Ostrander3 and Robert K. Wayne4 1 Department of Ecology & Evolutionary Biology, Rice University, MS 170, 6100 Main Street, Houston, TX 77005, USA 2 Department of Veterinary Integrative Biosciences, Texas A&M University, MS 4458, College Station, TX 77843-4458, USA 3 National Human Genome Research Institute, National Institute of Health, Comparative Cancer Section, 50 South Drive, MSC 8000, Bethesda, MD 20892-8000, USA 4 Department of Ecology & Evolutionary Biology, University of California, Los Angeles, CA 90095-1606, USA In large part, the relevance of genetics to conservation have often aided the management of rare and endangered rests on the premise that neutral marker variation in species. Consequently, given limited resources, there might populations reflects levels of detrimental and adaptive be little incentive to move from conservation genetics to genetic variation. Despite its prominence, this tenet has ‘conservation genomics’, particularly when traditional con- been difficult to evaluate, until now. As we discuss here, servation genetic issues in vertebrate animals and vascular genome sequence information and new technological plants are considered (Box 1). and bioinformatics platforms now enable comprehen- So which of the more traditional conservation genetics sive surveys of neutral variation and more direct infer- applications, if any, are in need of genomic tools and ences of detrimental and adaptive variation in species information? Clearly, many applications of molecular mar- with sequenced genomes and in ‘genome-enabled’ kers in conservation could be transformed by genomic endangered taxa. Moreover, conservation schemes approaches [12–15], and approaches such as metage- could begin to consider specific pathological genetic nomics could give rise to entirely novel conservation variants.