DOCSLIB.ORG

E036128.Draft-Revisions.Pdf

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
E036128.Draft-Revisions.Pdf BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 26, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020. Downloaded from Sex differences in the efficacy of anti-hypertensive treatment in preventing cardiovascular outcomes and reducing blood pressure: protocol for a systematic review and meta-analysis ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2019-036128 Article Type: Protocol Date Submitted by the 01-Dec-2019 Author: Complete List of Authors: Gasbarrino, Karina; Research Institute of the McGill University Health Centre, Medicine Labos, Christopher; Queen Elizabeth Health Complex, Cardiology Mastropietro, Victoria; McGill University Health Centre, Medical Library Hales, Lindsay; McGill University Health Centre, Medical Library Khan, Nadia; The University of British Columbia, Medicine Rabi, Doreen; University of Calgary Cumming School of Medicine, Medicine Daskalopoulou, Stella; Research Institute of the McGill University Health Centre, Medicine http://bmjopen.bmj.com/ Hypertension < CARDIOLOGY, CLINICAL PHARMACOLOGY, Protocols & guidelines < HEALTH SERVICES ADMINISTRATION & MANAGEMENT, Keywords: Cardiology < INTERNAL MEDICINE, Vascular medicine < INTERNAL MEDICINE on September 26, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 18 BMJ Open 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020. Downloaded from 5 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on September 26, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 18 BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020. Downloaded from 1 2 3 1 Sex differences in the efficacy of anti-hypertensive treatment in preventing cardiovascular 4 2 outcomes and reducing blood pressure: protocol for a systematic review and meta-analysis 5 6 3 1 2 3 3 4 7 4 Karina Gasbarrino, Christopher Labos, Victoria Mastropietro, Lindsay Hales, Nadia A. 8 5 Khan, 5Doreen M. Rabi, 1Stella S. Daskalopoulou 9 6 10 7 Author Affiliations 11 8 1Vascular Health Unit, Research Institute of McGill University Health Centre, Department of 12 9 Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada 13 2 14 10 Department of Cardiology, Queen Elizabeth Health Complex, Montreal, Quebec, Canada 15 11 3Medical Library, McGill University Health Centre, Montreal, Quebec, Canada 16 12 4Department of Medicine,For Center peer for Health review Evaluation and Outcomesonly Science, University of 17 13 British Columbia, Vancouver, British Columbia, Canada 18 14 5Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, 19 15 Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, 20 21 16 Canada 22 17 23 18 Emails 24 19 Karina Gasbarrino [email protected] 25 20 Christopher Labos [email protected] 26 21 Victoria Mastropietro [email protected] 27 22 Lindsay Hales [email protected] 28 29 23 Nadia A. Khan [email protected] 30 24 Doreen M. Rabi [email protected] 31 25 Stella S. Daskalopoulou [email protected] 32 26 http://bmjopen.bmj.com/ 33 27 Corresponding Author 34 28 Stella S. Daskalopoulou, MD, PhD. Department of Medicine, Research Institute of the McGill 35 29 University Health Centre, Glen Site, 1001 Decarie Boulevard, EM1.2230, Montreal, Quebec, 36 37 30 Canada, H4A 3J1. 38 31 39 32 Word Count 40 33 2,547 words on September 26, 2021 by guest. Protected copyright. 41 34 42 35 43 44 36 45 37 46 38 47 39 48 40 49 41 50 42 51 52 43 53 44 54 45 55 46 56 57 58 59 1 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 18 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020. Downloaded from 1 2 3 47 Abstract 4 48 5 6 49 Introduction: Hypertension is a leading cause of mortality worldwide and its prevalence is 7 50 expected to rise over the next decade. Sex differences exist in the epidemiology and the 8 51 pathophysiology of hypertension. It is well-established that anti-hypertensive treatment can 9 52 significantly reduce the risk for stroke and other CVD events. However, it remains unclear 10 53 whether this effect is dependent on sex. In this protocol we outlined a systematic review and 11 54 meta-analysis to summarize the current evidence evaluating and comparing the effectiveness of 12 55 anti-hypertensive therapy in 1) reducing blood pressure and 2) preventing cardiovascular 13 14 56 morbidity and mortality outcomes specifically in men versus women. 15 57 16 58 Methods and analysis:For The followingpeer electronic review databases willonly be searched: MEDLINE, 17 59 Embase, The Cochrane Library, PubMed, CINAHL Plus, Web of Science, grey literature 18 60 (Google Scholar), and several trial registries. Search strategies will be designed to identify 19 61 human (18+) randomized (and non-randomized) controlled trials, prospective and retrospective 20 21 62 cohort studies, and case-control studies concerning ‘sex-specific differences associated with the 22 63 efficacy of anti-hypertensive treatment’. Two investigators will independently review each 23 64 article included in the final analysis. Primary outcomes investigated are cardiovascular morbidity 24 65 and mortality and systolic and diastolic blood pressure. Pooled analyses will be conducted using 25 66 fixed-effects (Mantel–Haenszel) or random-effects (DerSimonian–Laird) models. Publication 26 67 bias will be assessed by visual inspection of funnel plots and by Begg’s and Egger’s statistical 27 68 tests. Between-studies heterogeneity will be measured using the I2 test. Sources of heterogeneity 28 29 69 will be explored by sensitivity, subgroup, and meta-regression analyses. 30 70 31 71 Dissemination: This is the first meta-analysis that will directly compare the efficacy of an anti- 32 72 hypertensive treatment regimen between men and women. Findings will be shared through http://bmjopen.bmj.com/ 33 73 scientific conferences and societies, social media, and consumer advocacy groups. Results will 34 74 be used to inform the current guidelines for management of hypertension in men and women by 35 75 demonstrating the importance of implementing sex-specific recommendations. 36 76 37 77 Keywords: sex, hypertension, blood pressure, anti-hypertensive therapy, cardiovascular 38 39 78 morbidity, cardiovascular mortality 40 79 on September 26, 2021 by guest. Protected copyright. 41 80 42 81 43 82 44 83 45 84 46 47 85 48 86 49 87 50 88 51 89 52 90 53 54 91 55 92 56 93 57 58 59 2 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 18 BMJ Open: first published as 10.1136/bmjopen-2019-036128 on 12 March 2020.
Load more

Recommended publications
  • (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao Et Al
    USOO9498481 B2 (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao et al. (45) Date of Patent: *Nov. 22, 2016 (54) CYCLOPROPYL MODULATORS OF P2Y12 WO WO95/26325 10, 1995 RECEPTOR WO WO99/O5142 2, 1999 WO WOOO/34283 6, 2000 WO WO O1/92262 12/2001 (71) Applicant: Apharaceuticals. Inc., La WO WO O1/922.63 12/2001 olla, CA (US) WO WO 2011/O17108 2, 2011 (72) Inventors: Tadimeti Rao, San Diego, CA (US); Chengzhi Zhang, San Diego, CA (US) OTHER PUBLICATIONS Drugs of the Future 32(10), 845-853 (2007).* (73) Assignee: Auspex Pharmaceuticals, Inc., LaJolla, Tantry et al. in Expert Opin. Invest. Drugs (2007) 16(2):225-229.* CA (US) Wallentin et al. in the New England Journal of Medicine, 361 (11), 1045-1057 (2009).* (*) Notice: Subject to any disclaimer, the term of this Husted et al. in The European Heart Journal 27, 1038-1047 (2006).* patent is extended or adjusted under 35 Auspex in www.businesswire.com/news/home/20081023005201/ U.S.C. 154(b) by Od en/Auspex-Pharmaceuticals-Announces-Positive-Results-Clinical M YW- (b) by ayS. Study (published: Oct. 23, 2008).* This patent is Subject to a terminal dis- Concert In www.concertpharma. com/news/ claimer ConcertPresentsPreclinicalResultsNAMS.htm (published: Sep. 25. 2008).* Concert2 in Expert Rev. Anti Infect. Ther. 6(6), 782 (2008).* (21) Appl. No.: 14/977,056 Springthorpe et al. in Bioorganic & Medicinal Chemistry Letters 17. 6013-6018 (2007).* (22) Filed: Dec. 21, 2015 Leis et al. in Current Organic Chemistry 2, 131-144 (1998).* Angiolillo et al., Pharmacology of emerging novel platelet inhibi (65) Prior Publication Data tors, American Heart Journal, 2008, 156(2) Supp.
    [Show full text]
  • 2D6 Substrates 2D6 Inhibitors 2D6 Inducers
    Physician Guidelines: Drugs Metabolized by Cytochrome P450’s 1 2D6 Substrates Acetaminophen Captopril Dextroamphetamine Fluphenazine Methoxyphenamine Paroxetine Tacrine Ajmaline Carteolol Dextromethorphan Fluvoxamine Metoclopramide Perhexiline Tamoxifen Alprenolol Carvedilol Diazinon Galantamine Metoprolol Perphenazine Tamsulosin Amiflamine Cevimeline Dihydrocodeine Guanoxan Mexiletine Phenacetin Thioridazine Amitriptyline Chloropromazine Diltiazem Haloperidol Mianserin Phenformin Timolol Amphetamine Chlorpheniramine Diprafenone Hydrocodone Minaprine Procainamide Tolterodine Amprenavir Chlorpyrifos Dolasetron Ibogaine Mirtazapine Promethazine Tradodone Aprindine Cinnarizine Donepezil Iloperidone Nefazodone Propafenone Tramadol Aripiprazole Citalopram Doxepin Imipramine Nifedipine Propranolol Trimipramine Atomoxetine Clomipramine Encainide Indoramin Nisoldipine Quanoxan Tropisetron Benztropine Clozapine Ethylmorphine Lidocaine Norcodeine Quetiapine Venlafaxine Bisoprolol Codeine Ezlopitant Loratidine Nortriptyline Ranitidine Verapamil Brofaramine Debrisoquine Flecainide Maprotline olanzapine Remoxipride Zotepine Bufuralol Delavirdine Flunarizine Mequitazine Ondansetron Risperidone Zuclopenthixol Bunitrolol Desipramine Fluoxetine Methadone Oxycodone Sertraline Butylamphetamine Dexfenfluramine Fluperlapine Methamphetamine Parathion Sparteine 2D6 Inhibitors Ajmaline Chlorpromazine Diphenhydramine Indinavir Mibefradil Pimozide Terfenadine Amiodarone Cimetidine Doxorubicin Lasoprazole Moclobemide Quinidine Thioridazine Amitriptyline Cisapride
    [Show full text]
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • C:Hofmann\1Lithof.Doc 27.02.2010
    1 C:Hofmann\1Lithof.doc 27.02.2010 List of Publications Dissertation Hofmann, F. (1968) "Die Wirkung einiger Colchizinderivate auf den Mäuse-Ascites-Tumor" Medizinische Fakultät der Universität Heidelberg Habilitation Hofmann, F. (1977) "Characterisierung der cAMP-abhängigen Protein-kinasen" Fakultät für Theoretische Medizin, Universität Heidelberg I Referierte Arbeiten Hofmann, F., Sold, G. (1972) "A protein kinase activity from rat cerebellum stimulated by guanosine-3`:5`- monophosphate" Biochem. Biophys.Res.Comm. 49, 1100-1107 Sold, G., Hofmann, F. (1974) "Evidence for a guanosine-3`:5`-monophosphate-binding protein from rat cerebellum" Eur.J.Biochem. 44, 143-149 Shizuta, Y., Beavo, J.A., Bechtel, P.J., Hofmann, F., Krebs, E.G. (1975) "Reversibility of the adenosine-3`:5`- monophosphate-dependent protein kinase reaction" J.Biol.Chem. 250, 6891-6896 Hofmann, F., Beavo, J.A., Bechtel, P.J., Krebs E.G. (1975) "Comparison of adenosine-3`:5`-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle" J.Biol.Chem. 250, 7795-7801 Hofmann, F., Bechtel, P.J., Krebs, E.G. (1977) "Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues" J.Biol.Chem. 252, 1441-1447 Schwechheimer, K., Hofmann, F. (1977) "Properties of regulatory subunit of cyclic AMP-dependent protein kinase (peak I) from rabbit skeletal muscle prepared by urea treatment of the holoenzyme" J. Biol. Chem. 252, 7690-7696 Flockerzi, V., Speichermann, N., Hofmann, F. (1978) "A guanosine-3`:5`monophosphate-dependent protein kinase from bovine heart muscle" J.Biol.Chem. 253, 3395-3399 Schmidt-Gayk, H., Löhrke, H., Fischkal, A., Goerttler, K., Hofmann F. (1979) "Urinary cyclic AMP and bone histology in Walker Carcinosarcoma: Evidence of parathyroid hormone-like activity" Eur.J.
    [Show full text]
  • Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning
    Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy using Machine Learning Kate Wang et al. Supplemental Table S1. Drugs selected by Pharmacophore-based, ML-based and DL- based search in the FDA-approved drugs database Pharmacophore WEKA TF 1-Palmitoyl-2-oleoyl-sn-glycero-3- 5-O-phosphono-alpha-D- (phospho-rac-(1-glycerol)) ribofuranosyl diphosphate Acarbose Amikacin Acetylcarnitine Acetarsol Arbutamine Acetylcholine Adenosine Aldehydo-N-Acetyl-D- Benserazide Acyclovir Glucosamine Bisoprolol Adefovir dipivoxil Alendronic acid Brivudine Alfentanil Alginic acid Cefamandole Alitretinoin alpha-Arbutin Cefdinir Azithromycin Amikacin Cefixime Balsalazide Amiloride Cefonicid Bethanechol Arbutin Ceforanide Bicalutamide Ascorbic acid calcium salt Cefotetan Calcium glubionate Auranofin Ceftibuten Cangrelor Azacitidine Ceftolozane Capecitabine Benserazide Cerivastatin Carbamoylcholine Besifloxacin Chlortetracycline Carisoprodol beta-L-fructofuranose Cilastatin Chlorobutanol Bictegravir Citicoline Cidofovir Bismuth subgallate Cladribine Clodronic acid Bleomycin Clarithromycin Colistimethate Bortezomib Clindamycin Cyclandelate Bromotheophylline Clofarabine Dexpanthenol Calcium threonate Cromoglicic acid Edoxudine Capecitabine Demeclocycline Elbasvir Capreomycin Diaminopropanol tetraacetic acid Erdosteine Carbidopa Diazolidinylurea Ethchlorvynol Carbocisteine Dibekacin Ethinamate Carboplatin Dinoprostone Famotidine Cefotetan Dipyridamole Fidaxomicin Chlormerodrin Doripenem Flavin adenine dinucleotide
    [Show full text]
  • Customs Tariff - Schedule
    CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2020 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT, CPTPT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Treatment of Pulmonary Hypertension with Carbonic Anhydrase Inhibitors in Combination with a Sympathomimetic Amine
    (19) TZZ _Z9B_T (11) EP 2 167 099 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/7048 (2006.01) A61K 31/137 (2006.01) 17.10.2012 Bulletin 2012/42 A61K 31/423 (2006.01) A61K 31/433 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01) (2006.01) (21) Application number: 08767969.2 A61P 11/00 (22) Date of filing: 30.05.2008 (86) International application number: PCT/US2008/006850 (87) International publication number: WO 2008/156550 (24.12.2008 Gazette 2008/52) (54) TREATMENT OF PULMONARY HYPERTENSION WITH CARBONIC ANHYDRASE INHIBITORS IN COMBINATION WITH A SYMPATHOMIMETIC AMINE BEHANLDUNG VON PULMONALER HYPERTONIE MIT CARBONSÄUREANHYDRASE- INHIBITOREN IN KOMBINATION MIT EINEM SYMPATHOMIMETISCHEN AMIN TRAITEMENT DE L’HYPERTENSION PULMONAIRE AVEC DES INHIBITEURS DE L’ANHYDRASE CARBONIQUE (84) Designated Contracting States: •TAM,Peter AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Redwood City, CA 94061 (US) HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT • WILSON, Leland RO SE SI SK TR Menlo Park, CA 94025 (US) • PETERSON, Craig (30) Priority: 13.06.2007 US 818306 Mountain View, CA 94040 (US) (43) Date of publication of application: (74) Representative: Finnie, Isobel Lara et al 31.03.2010 Bulletin 2010/13 Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP (60) Divisional application: Alder Castle 12172276.3 / 2 500 024 10 Noble Street London (73) Proprietor: Vivus, Inc. EC2V 7JX (GB) Mountain View, CA 94040 (US) (56) References cited: (72) Inventors: WO-A-00/76493 WO-A-2006/063078 • NAJARIAN, Thomas WO-A-2007/084290 WO-A-2008/060963 Los Osos, CA 93402 (US) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations.
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
    [Show full text]
  • Ovid MEDLINE(R)
    Supplementary material BMJ Open Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily <1946 to September 16, 2019> # Searches Results 1 exp Hypertension/ 247434 2 hypertens*.tw,kf. 420857 3 ((high* or elevat* or greater* or control*) adj4 (blood or systolic or diastolic) adj4 68657 pressure*).tw,kf. 4 1 or 2 or 3 501365 5 Sex Characteristics/ 52287 6 Sex/ 7632 7 Sex ratio/ 9049 8 Sex Factors/ 254781 9 ((sex* or gender* or man or men or male* or woman or women or female*) adj3 336361 (difference* or different or characteristic* or ratio* or factor* or imbalanc* or issue* or specific* or disparit* or dependen* or dimorphism* or gap or gaps or influenc* or discrepan* or distribut* or composition*)).tw,kf. 10 or/5-9 559186 11 4 and 10 24653 12 exp Antihypertensive Agents/ 254343 13 (antihypertensiv* or anti-hypertensiv* or ((anti?hyperten* or anti-hyperten*) adj5 52111 (therap* or treat* or effective*))).tw,kf. 14 Calcium Channel Blockers/ 36287 15 (calcium adj2 (channel* or exogenous*) adj2 (block* or inhibitor* or 20534 antagonist*)).tw,kf. 16 (agatoxin or amlodipine or anipamil or aranidipine or atagabalin or azelnidipine or 86627 azidodiltiazem or azidopamil or azidopine or belfosdil or benidipine or bepridil or brinazarone or calciseptine or caroverine or cilnidipine or clentiazem or clevidipine or columbianadin or conotoxin or cronidipine or darodipine or deacetyl n nordiltiazem or deacetyl n o dinordiltiazem or deacetyl o nordiltiazem or deacetyldiltiazem or dealkylnorverapamil or dealkylverapamil
    [Show full text]