ALS Therapy Development Institute 10 year Anniversary 1999 - 2009

Annual report 2009 Letter from the CEO

The ALS Therapy Development Institute is unlike any other research center in the world. As you will see from the following pages, the Institute that you have helped to build has overcome many challenges throughout the years. It wasn’t a gift from the government or major corporations that formed ALS TDI; it was the accumulated generosity and sense of urgency shared by hundreds of families from all over the world that laid the foundation, fueling research year after year. This dedication has provided nearly $60 million to ALS TDI and created a center of excellence solely dedicated to responding to the ALS crisis. Just as we were driven and inspirited by ALS patients ten years ago, so are we today.

The face of the Institute has changed dramatically over the years as well. New families have joined those whom have been here since the beginning. New technology and researchers have become part of the team, allowing us to do more with every dollar we receive. Each and every ALS patient, caregiver, family member, donor, friend, employee, collaborator, consultant, and partner plays an important role in the advancement of our mission. Every new step taken toward that goal is only possible because of those that came before, and we continue to honor past contributions by never wavering in our resolve.

In order to begin to tell the story of ALS TDI we must recognize the families that have funded our research, and as such this annual report starts by first listing the Family Funds that have made our work possible. The generosity of the ALS community and our partners at the MDA and the Department of Defense, along with the dozens of academic and industry collaborations that we work with have significantly shortened the length of time and cost of drug development for ALS.

This annual report contains a brief history of ALS TDI over the past 10 years. The core values that drive us today have not changed from what they were ten years ago: courage and love, challenge and respect, hope, an adventurous spirit and patients today. We will always make decisions with those battling ALS today at the forefront of our minds. It is a privilege to report to you, that over the past year, we have made great strides, however more work is needed if we are to turn incremental advancements into treatments for patients today.

I am daily reminded of the responsibility I shoulder as I look back at ALS TDI from the beginning. What this place means to those that have been part of its creation and growth, the loss that has been incurred, and the hope we must work daily to make real. As a scientist it is my duty to look at ALS in an unbiased way and ask the tough questions about ALS. As the head of ALS TDI it is my profound responsibility to ensure our progress, for all those that supported us and for those counting on us today. This is your lab and I thank you for your support.

Sincerely,

Steve Perrin, Ph.D. CEO & Ch i e f Scientific Of f i ce r

Augie Nieto, Ch a i r m a n o f t h e Bo a r d

Bo a r d o f Di r ec t o r s Leslie Michelson, Vice Chair, Theodore Reich, Treasurer, James Allen Heywood, John Heywood, Spiros Jamas, Robert Rodin, Alexander Cappello, John Sutherland, Keith Melanson, Stan Appel ALS Therapy Development Institute Pull out 10 year Anniversary

Will Hubben, pALS, First annual established the ALS/MND Sean Forrester Scott Belly Dance Research Mail List (later, after joins ALS TDF as FoRUm An volunteer following James Allen Heywood starts Extravaganza ALS Therapy Development Institute his death, it is renamed in the ALS Therapy Development takes place his honor as the Hubben anonymous his mother’s Foundation three months at Karoun in The virtual, web-based bulletin Digest). Within its first year, donor makes diagnosis. ALS runs board, “The ALS Forum,” is in his family and after his brother Stephen is Newton, MA. the mailing list grows to over ALS TDF opens ALS TDF’s Founder and CEO, James Allen $1 million diagnosed with amyotrophic launched. grant to Sean himself has The Foundation applies for 1,000 email addresses. first lab inside New Heywood, begins to hold “ALS 101” sessions for lateral sclerosis (ALS, Lou ALS TDF. a 50/50 chance of Phase I Stem Cell Transplant “Neurobase” developed England Medical ALS patients. The goal is to provide information 1999 Gehrig’s disease). A nonprofit developing it. trial. If approved, it would to track leads and Center in Boston. and encourage discussion among stakeholders biotech, ALS TDF is dedicated to First therapy concept www.als-tdf.org launched. 2000 Alex & Brit be the first of its kind for gather information to regarding drug development. drug development for patients developed: replace d’Arbeloff ALS in the world. support research and make $300,000 2001 today. Stephen is the first donor, EAAT2 protein using development. writing a check for $10,000 and gene therapy. donation to telling his brother to “get going.” ALS TDF. “ALS In-Vivo Screening Program” The Uptake Therapy launched in the Fall. Alex & Brit ALS TDF raises ALS TDF’s “Friends & Family Project kicked off Scaled up to become d’Arbeloff $434,761 in its first Community” goes live. Web ALS Hope/Hobler Foundation in partnership with largest in the world. Heywood brothers ALS TDF receives approval www.als-tdf.org gets facelift; make $100,000 year of existence. based fundraising community 27 drugs tested in SOD1 makes $500,000 gift to ALS TDF. The Dr. Jeffrey Rothstein and ALS TDF featured to conduct the world’s designed to include results from donation to launched as one of the first in mouse; 2 hits. Foundation renames its main drug- at John Hopkins in New Yorker ALS TDF raised first stem cell trial for ALS. research trials and better connect ALS TDF. the non-profit world. screen program the “ALS Hope Drug University. 1st annual “Night at Fenway” event held. magazine exposé $1,562,126 in 2000. Stephen Heywood and 2 patients and researchers together. 2001 Discovery Center”. “Curing the Incurable.” others participate.

ALS TDF screens Dapsone, Established 4 external research collaborations WHI-P131, Celebrex, with academics and more than 25 partnerships Chlorpromazine, Copasone, 58 drugs with biotechs and pharmaceutical companies. Gusperimus, Quinacrine, evaluated Riluzole, Thalidomide, CVF, throughout DDC IIG, Indomethacin, 2003, including The Friends & Family Leflunomide, Memantine 8 advanced Community, the Foundation’s and others. efficacy screens. 2002 main fundraising arm, doubles Ten ALS 101 sessions held 2003 2001 throughout the year. New funding allows the lab its income to $1.8 million. ALS TDF executes a combination ALS TDF moves across the to move to a larger space at drug trial of Ritonavir and Charles River into a larger 28 drugs evaluated and the Massachusetts College of Hydroxyurea at the University of Ronya Kozmetsky ALS TDF raised research facility located in the 3 preliminary hits in the Pharmacy by the end of the year. San Francisco in Partnership with makes $1 million SOD1 mouse model. $4,018,069 in 2001. Harvard Partners building. Alex & Brit d’Arbeloff the Larry L. Hillblom Foundation. pledge to ALS TDF An anonymous donor provides a $300,000 make $1,000,000 ALS TDF raised after the passing of her grant funding the development of a new donation to ALS TDF. $4,335,417 in 2002. husband, George, to 2003 bioinformatics system at ALS TDF. ALS a year earlier.

Passion For Life 1st Annual Leadership Fund, inspired Summit held in Scientists at the Institute in 2000 by Cambridge at the innovate a novel device A Biosafety Level 2 Lab is pALS Mary Lou Massachusetts known as an intrathecal constructed at ALS TDF. Krauseneck, Biotechnology Council The Fran Delaney catheter, which delivers The secure lab allows reaches its followed by a lobster 2003 PGA Tour Golfers Jeff Julian and Fund hits their $1 potential therapeutics expansion of gene Mass spectromety core $1 million dinner and Awards at Tom Watson, together with Tom’s million cumulative directly to the spinal therapy and cell-based created. The goal is fundraising the Heywood’s home Watson’s caddy Bruce Edwards, start fundraising ALS TDF staff attend 2004 to monitor drug levels milestone. in Newton, where the cord of the mouse. ALS TDF hires industry treatment pipelines. “Driving 4 Life,” a fundraising effort milestone in less Society for Neuroscience in attained in any tissue type. Foundation first began ALS TDF research team trained discovery experts, based on golf. Campaign raises $1 than 3 years. San Diego. to operate. establishing a dedicated million by end of the year. attends Society for 2004 2005 Neuroscience meeting Discovery Biology Core. ALS TDF purchases a in New Orleans. powerful Zeiess X1 microscope and builds up its molecular imaging ALS TDF raises The 1st Annual “A His Brother’s capabilities thanks to an $3,509,483 - spends “Friends Cure is Coming!” walk Keeper, a book allocation from the Jeff 79% on R&D. and Family is held. Dozens of by Jonathan Nearly 100 cyclists, including Hadley Fund. This makes the Community” patients and families Weiner, many pALS, participate in the Foundation the grows to include walk from Lexington chronicles Tri-State Trek, a 270-mile bike largest funded R&D 70 separate and Battle Green to the program exclusively Stephen’s ride from Boston to NY. Jamie articulates the active funds. ALS TDF moves to its Old North Church in focused on ALS. Group surpasses illness and Apollo projects, an With a second $500,000 grant, current location, a 16,000 Gene Expression Core launched Boston to raise ALS $2 million in Jamie’s ambitious vision for the ALS Hope/Hobler Foundation square foot space in at ALS TDF with the purchase of a awareness. annual grassroots founding of ALS TDF which includes becomes the second foundation Cambridge’s bio tech hub Taqman. This high-end device is fundraising. ALS TDF. novel discovery and drug to provide $1 million in funding to Kendall Square. capable of measuing the expression development approaches ALS TDF. ALS TDF raises $3,447,963 Leadership Awards created, including: Fran Delaney Challenge & Respect Award, Mary Lou Krauseneck Continued ALS TDF raised of genes, aiding in the search for combined to move drugs in its 5th year of existence. Courage & Love Award, Steve Milne Award, and Stephen Heywood Patients Today Award. $3,990,771 in 2003. biomarkers of disease. into the clinic faster. ALS Therapy Development Institute 10 year Anniversary Annual report 2009

One-of-a-kind bioinformatics and ALS TDF becomes ALS Steve Milne laboratory management system, Therapy Development Fund reaches its “KnowledgeSphere”, is built at Institute (ALS TDI) following $1 million goal. ALS TDI allowing for seamless Augie Nieto, the annoucement of a three- Commits to data analysis and management of diagnosed with year, $18 million grant from hitting its next the world’s largest drug discovery ALS in March MDA’s Augie’s Quest. target in half ALS Therapy Development Institute 2005, commits Leadership Summit expands dramatically in effort dedicated to treating ALS. the time. to raising Steve Perrin, Ph.D., becomes its second year, moving to the Hotel @ MIT. the organization’s first chief $18 million Drs. John Lincecum, Robert Bowser and Dan ALS TDI completes scientific officer. 10 y ear A n n i v ersar y and becomes Benjamin give updates on their work. The event the first ever chairman of features talks from newly hired science team The In Vitro Validation Team is organized at ALS TDF. comprehensive the board. members, and a screening of “So Much So Fast”. Their primary charge is to validate the activity of 2007 gene expression 2006 small molecule, protein biologics and gene therapy database of the 1999 - 2009 products prior to advancing them to into full in- ALS TDI purchases a Laser “So Much SOD1 mouse in vivo (animal) testing for efficacy. partnership with Capture Microdisection (LCM) to So Fast”, a ALS TDF GeneLogic. investigate cell-specific changes documentary has a record in gene and protein expression. about the November 26th The US breaking 3rd Annual Leadership Heywood’s, – After eight fundraising Summit fills the room at After eight Department of ALS TDI launches “Yoda” and “Darth,” two and ALS TDF, years living with year - the Museum of Science years leading Defense make novel gene therapy BioMek automation robots premiers ALS, Stephen recognizing in Boston. Drs. Ray ALS TDI, Jamie a $1.8 million pipeline and partners become permanent members at the Heywood, the Sean Scott $5,181,635 in Onders, Dale Lange and steps down as grant to ALS TDF with Microbix to of the team at ALS TDI. They Sundance inspiration for is named donations. Hans Kiersted make CEO and joins for research into develop targeted are tasked with speeding up 2007 Film Festival. ALS TDF, president of presentations. the board. ALS treatments. vectors. the processing of RNA and passes away. ALS TDF. genotyping.

For the second 4th Annual Summit ALS TDI enters year in-a-row, Leadership held at the into partnership the DOD Holiday Inn at MGH in Boston Conceived as the world’s first non-profit with Allen Institute funds ALS TDI, and features talks from Drs. for Brain Science. awarding a $1 Sharon Hesterlee, Stanley Begins massive in million grant. Appel, Michael Strong, situ hybridization 2007 Jean-Pierre Julien and Tom experiment. Friends for Faye Fund reaches $1 million in total fundraising. biotechnology company, and born out Caltagirone. For the first time RGK Foundation US Department of Defense ever, the event is broadcast live over the internet, funded 2008 ALS TDI partners makes $1 million, makes $1.1 million grant to by and at the challenge of with 6 clinics to two-year grant to ALS TDI for research. ALS TDI scientists publish Jeff Cronon, an ALS patient of a brother’s love, ALS TDI has become collect blood ALS TDI. guidelines for researchers in Atlanta. and tissue ALS TDI collaborates with using the G93A-SOD1 With $11,022,032 in samples from California Stem Cell. Work mouse model of ALS in donations in 2008, Tri-State Trek ALS TDI launches ALS patients for suggests that stem cells can the journal, Amytrophic ALS TDI begins to hold ALS TDI continued to one of the world’s foremost innovators in surpasses $1 million its Ambassador cross-referencing engraft and survive in spinal Lateral Sclerosis. The Monthly Webinars. In its first grow its capacity, and against gene in total fundraising. Program, designed cord of SOD1 mice. Groups paper’s title is “Design, Prize4Life selects ALS TDI year, several hundred pALS science team to include ALS TDI raises an astonishing expression to empower pALS extend collaboration work Power and Interpretation model standards as basis and cALS join together online more than 30 full-time $9,687,302 in 2007 - making pathways and cALS with to develop cell-based drug SFO Foundation makes of Studies in the Standard for its $1 million biomarker each month to receive updates professional researchers. the Institute one of the best organization and research and development of potential identified in delivery tools to treat ALS. Murine Model of ALS.” from the lab and ask questions $1.5 million grant. and therapeutic prize. fundraising skills. funded private research SOD1 database. about research and trials. organizaitons in the world focused on a single disease. treatments for ALS.

Board Member, Stanley 5th Annual Summit is held at the Scientists submit a paper Asklepios and ALS TDI Appel, M.D., tells a Hotel Marlowe in Cambridge and New technology and researchers have become part of the team, allowing us to do more with every dollar we regarding the discovery of ALS TDI collaborate on the Congressional hearing webcast live over the internet. 00846 to Nature Genetics entitled development of novel Applied Proteomics becomes that “ALS is not an Presentations were given by receive. Each and every ALS patient, caregiver, family member, donor, friend, employee, collaborator, consultant, “From Transcriptome Analysis to adeno-associated viral a strategic partner in ALS TDI’s incurable disease, it is Drs. John McCarty, Jude Samulski, Therapeutic Anti-CD40L Treatment vectors to be used in ALS THERA PY DEVEL OPMENT INSTITU T E and partner has played an important role in the growth of ALS TDI. effort to characterize protein an underfunded one.” Zuoshang Xu and Erika Holzbaur. 10 Y E A R ANNI VERSARY drug devleopment in the SOD1 Model of Amyotrophic expression changes associated Steve Perrin makes first public 1999 - 2009 Lateral Sclerosis.” research. with disease onset and presentation of data on ALS TDI progression. 00846 to peers and ALS community. 2009 Based on significant

progress made ANNUAL REPORT 2009 Michael Goldsmith, an ALS TDI Ambassador and ALS TDI launches a “virtual lab as chief scientific ALS Patient, helps to inspire the creation of Major tour” on its website and adds ® officer, Steve League Baseball’s 4 uALS Awareness Campaign. A Perrin, Ph.D., is ALS TDI redesigns its an “Ask a Researcher” button ALS TDI raises $9,360,831. joint effort between Major League Baseball, ALS TDI, February 6th named as the website, and launched to every web page on its site Bringing the total raised and MDA’s Augie’s Quest, the ALS Association and Project – Sean Scott, Institutes CEO. www.als.net in April. to provide direct link between spent on research to more A.L.S., culminates in a League-wide awareness president of ALS patients, families and researchers. than $56 million over the initiative on July 4th, 2009; the 70th anniversary of TDI, passes away past 10 years. Lou Gehrig’s retirement from baseball. from ALS. 2009 ALS TDI Annual Report | 1 Definition: A dedicated group of people joined together by a shared lineage or ambition to create a world where The Family Funds at ALS TDI ALS can be stopped. Usually named in honor of a person diagnosed with ALS.

There are more than 300 of these funds, each playing an important role in driving the research at ALS TDI. The following list recognizes Family Funds that have provided at least $10,000 over the past 10 years. A complete list, with links to bios and fund activities, is available on our website at www.als.net.

Cumulative Fund Totals as of 12/31/09

Year Year Started Started

$18M+ Margaret Roblin Fund 2008 MDA’s Augie’s Quest 2007 Jenny Stoddard Family Fund 2003 Stanfield Family ALS Research Fund 2003 $6M+ Stephen Heywood Family Fund 1999 $100K-$249K Jim Airey Fund 2001 $3M+ Jean Angell Fund 2002 Sean Forrester Scott Fund 2001 Pam Barshack Fund 2005 Blazeman Fund 2005 $2M+ Rick Bowling Fund 2006 Chris Hobler / Hope Happens 2001 Brooks Family Foundation 2002 Kozmetsky Family Fund 2003 Christy Sloan Fund 2005 Jeff Cronon Fund 2007 $1M+ David Dorfman Fund 2001 Fran Delaney Fund 2001 Dick Douglass Effort 2001 Friends for Faye Fund 2004 Matt Dowd Fund 2002 Mary Lou Krauseneck Fund 2002 Dunphy Sister’s Fund 2002 Stephen Milne Effort 2002 Larry Ellis Fund 2004 Corey Reich Fund 2007 Steve Fowler Fund 2001 Tri-State Trek 2005 David Green Fund 2000 Mike Justice Fund 2007 $500K-$999K Kim Family Fund 2000 Bruce Edwards/Tom Waston Fund 2003 Phil Kramer Fund 2006 DeeDee Fornengo Fund 2002 Chris Martin Fund 2005 Jeff Julian Fund 2003 Ken Melanson’s Quest for a Cure 2004 Anthony Tucker Fund 2000 Pittsburgh Families Efforts 2003 Jim Raspanti Fund 2002 $250K-$499K Dick Sanderson Fund 2005 ALS Family Charitable Fund 2001 Herb Schwartz Fund 2004 Tom Becker Fund 2004 Scott Stafne ALS Research Fund 2004 Jim Canty Fund 2000 Team Gey 2007 Pam Callahan Fund 2007 Ternet Friends Fighting ALS Fund 2003 Marie Garratt Memorial Fund/Dash for a Cure 2003 Torretta Fund 2004 Jeff Hadley Fund 2006 Michael Winston Research Fund 2008 HMS Host Fund 2004 Larry Manes Fund 2000 $50K-$99K The James and Alice McGonagle Charitable Trust 2004 A Cure is Coming Walk 2005 Jack Orchard Effort 2001 Lee Blaskovich Memorial ALS Research Fund 2005 Ride for Life Fund 2000 Rene Bourassa Fund 2005

2009 ALS TDI Annual Report | 7 A Cure is Coming Walk 2005 Lee Blaskovich Memorial ALS Research Fund 2005 Rene Bourassa Fund 2005 Steve Carlin Fund 2001 The Family Funds at ALS TDI continued Paul Gerbick Fund 2002 Go To Bed Laughing Fund 2003 Michael Goldsmith Fund 2009 Steve Greenspan Fund 2006 Year Year Trude Klugman Fund 2000 Started Started Rubin Kuznitsky Fund 2004 Tom Larsen Challenge 2003 Edward Brigham Fund 2001 ALS Soccer Cup 2004 Manhattan Fund 2008 Steve Carlin Fund 2001 Ann Arbor Active Against ALS Fund 2008 Melba Moeck Fund 2005 Paul Gerbick Fund 2002 Robin Arnold Fund 2005 Roby Molnar Swiss Fund 2004 Go To Bed Laughing Fund 2003 Barretti Family Fund 2006 Jennifer Nichols Fund 2000 Michael Goldsmith Fund 2009 Big G Fund 2007 Olson Family ALS Research Foundation 2006 Steve Greenspan Fund 2006 Joan Blum Fund 2000 Orange County Fund 2008 Trude Klugman Fund 2000 Peter Catucci Fund 2009 Parkersburg Area Community Foundation 2008 Rubin Kuznitsky Fund 2004 Lynn Capria Fund 2006 Payne Family Fund 2006 Tom Larsen Challenge 2003 Peter Colichidas Fund 2009 Jeff Repetto Fund 2004 Elliot Macht Fund 2000 Dennis Coogle Fund 2009 Joe Shambo Fund 2004 Manhattan Fund 2008 Cubby Cronan Fund 2004 Chris Stoikos Fund 2005 Melba Moeck Fund 2005 Donna Dake ALS Research Fund 2004 The Dont Tap Out Fund 2009 Roby Molnar Swiss Fund 2004 Eddie Esparza Fund 2007 Westhaven Charities Fund 2007 Jennifer Nichols Fund 2000 Father/Son Fund 2009 Stephen Yates Fund 2000 Olson Family ALS Research Foundation 2006 Friends of Harry Gianneschi 2002 Orange County Fund 2008 Griffin Family 2006 $25K-$49K Parkersburg Area Community Foundation 2008 Hope for Heidi Fund 2009 5430 Sports Fund 2007 Payne Family Fund 2006 Jenny Hoff Spokane Family Fund 2007 Dean Adraktas Fund 2001 David Reinstein Fund 2003 Jack Hoffman Fund 2000 Linda Anton Fund 2005 Jeff Repetto Fund 2004 Will Hubben ALS Research Fund 2002 Neil Brourman Fund 2001 Joe Shambo Fund 2004 Nick Huber Fund 2008 Brian Byrd Fund 2007 Chris Stoikos Fund 2005 Jim Hughes Fund 2006 Caccomo Family Foundation 2005 The Dont Tap Out Fund 2009 Deane Jewell’s Team 2003 Costa Family Fund 2008 Westhaven Charities Fund 2007 Walter Knopp Fund 2003 Laughlin Family Fund 2001 Stephen Yates Fund 2000 Peggy Lanza Fund 2002 Steve Lewis Fund 2002 Elaine Leavitt Fund 2005 Maine West High School Fund 2008 $25K-$49K Cyndee Luedecking Fund 2006 Jan Monier Fund 2008 5430 Sports Fund 2007 Bernie Martinelli Fund 2010 Northport High School Fund 2007 Dean Adraktas Fund 2001 Doug McGuinnes Fund 2005 Anita Schein Hecker Fund 2007 Linda Anton Fund 2005 Scott McWhorter Fund 2008 Jim Slovick Fund 2005 Neil Brourman Fund 2001 Meadowlark Fund 2007 Ellen Sutherland Fund 2005 Brian Byrd Fund 2007 Medved Fund 2007 The Carter Family ALS Fund 2003 Caccomo Family Foundation 2005 Meridiths Fight 4 Life 2008 Tow Family Fund 2003 Costa Family Fund 2008 Michael Donnelly Fund 1999 Jeff Ureel Fund 2002 Laughlin Family Fund 2001 Richard M. Mott Effort 2001 Steve Weekes Fund 2005 Steve Lewis Fund 2002 Myrtle Beach Golf Holiday Fund 2004 Maine West High School Fund 2008 Oakland Activities Association 2009 $10K-$25K Jan Monier Fund 2008 Roger Poirier Fund 2001 Peggy Lanza Fund 2002 Northport High School Fund 2007 Ride for Roger 2009 ALS Hope San Diego Fund 2009 Anita Schein Hecker Fund 2007 Bob Rosencrans Fund 2008 Jim Slovick Fund 2005 Salzarulo Fund 2009 Ellen Sutherland Fund 2005 Paul Sundman Fund 2007 The Carter Family ALS Fund 2003 Carl Tanner Fund 2004 Tow Family Fund 2003 Teach to Fight ALS 2004 Jeff Ureel Fund 2002 Team Virden 2007 Steve Weekes Fund 2005 Team Sheila 2008 Its Just Lunch Fund 2007 $10K-$25K Matt White Fund 2008 Bryan & Mark Allain Fund 2002 Wolfmom Family Fund 2002 ALS Hope San Diego Fund 2009

8 | ALS TDI Annual Report 2009 tHE The Leadership Giving Circle includes all individual Leadership Giving donors that have provided significant financial support Accelerate Research to ALS TDI in the previous calendar year. Each member is recognized here in the 2009 Annual Report, at our annual Leadership Summit and on our website.

Calendar Year 2009 Research ChampionO ($25,000+) Research Steward ($5000+) continued Name Fund Name Fund Department of the Army Stephen and Bernadette Cooper Mary Lou Krauseneck Insource Services, Inc. CT Friends for ALS Research Javier Burillo Corey Reich Fund Dalio Family Foundation INC Maine Township High School Salvi and Karen Dellabarca Corey Reich Fund Major League Baseball Charities Inc Carolyn Dietz Corey Reich Fund Muscular Dystrophy Association MDA’s Augie’s Quest Charles and Robin Ebert Charles Ebert Fund Theodore and Wendy Reich Corey Reich Fund Amy Goldberg Regina Schreiber Fund RGK Foundation Peter John Garratt Marie Garratt Memorial Fund Ron Russ Karen Gordon Michael Winston Research Fund Sierra Pacific Foundation Corey Reich Fund Mr and Mrs Wynne Gulden Jr Chris Stoikos Memorial Chris Stoikos Fund Kally and Jody Hearron Tim Shellenberger Memorial Fund Taylor Farms Pacific Inc Corey Reich Fund James Hebert Corey Reich Fund The James and Alice McGonagle Charitable Fund Help America Foundation Total Tec Systems, Inc. Fran Delaney Fund Jennifer Huntington Stephen Heywood Fund Westphal Family Foundation Corey Reich Fund Johnson & Johnson Ben Joyce Corey Reich Fund Jamie and Gail Keatin Corey Reich Fund Beth Kemph Friends for Faye Fund Research Visionary ($10,000+) Mickey Kieffer Michael Winston Research Fund Name Fund Life Threatening Illness Charity of America Mark Magliocchetti 4uALS Major League Baseball Ann Arbor Active Against ALS New England Fund ALS Family Charitable Foundation Inc ALS Family Charitable Fund Markstein Foundation Corey Reich Fund Caccomo Family Foundation Keith and Jill Melanson Ken Melanson Fund Core Network LLC Rick Bowling Fund Oakland Activities Association Frank and Judy Creamer Greg and Hanna Ostoff Pam Callahan Fund Brit d’Arbeloff Stephen Heywood Fund Lauren Pariseau HMS Host Fund Fran Delaney Foundation Fran Delaney Fund Pepin Distributing Compagny HMS Host Fund Carol Ann Garratt Marie Garratt Memorial Fund Pfizer Foundation Matching Gift Program In Re Erie Family Life Settlement Fund Michael Pierce Michael Winston Research Fund Adelard A. and Valeda Lea Roy Foundation Proteus Design Don and Toni Loback Friends for Faye Fund Ken Rawlings Corey Reich Fund Herbert and Suzanne Lynskey Stanfield Family ALS Research Fund Raynier Institute & Foundation Nokia Inc Phil Kramer Fund Reynolds Smith and Hills Inc. HMS Host Fund Olson ALS Foundation INC John and Mary Ricksen Corey Reich Fund Melanie Pasias Larry and Susan Ricksen Corey Reich Fund Doug and Ellen Reich Corey Reich Fund Richard and Nancy Robinson Corey Reich Fund Dawn Sanderson Dick Sanderson Rosy S. Golf Outing JoEllen Shea David and Mitzi Sabato Friends for Faye Fund The Jeff Julian ALS Foundation ALS TDI Golf John and Iola Sobeck Mary Lou Krauseneck The Overaa Family Group Corey Reich Fund Taylor Family Investments LLC. Corey Reich Fund The Tinsley Group Inc HMS Host Fund Jay Tenenbaum Stephen Heywood Fund The Thorson Foundation The MBK Foundation Corey Reich Fund Westhaven Charities Inc ALS TDI Golf The Stella Matutina O’Connor Foundation Mary Lou Krauseneck Woodbine Bend Golf Course Jenny Stoddard Fund Daniel and Theresa Walner Corey Reich Fund

Research Steward ($5000+) Research Advocate ($2500+) Name Fund Name Fund

A Midwinter Night Dream Alpha Baking Company ALS Benefit Account Anthony Tucker Fund ALSSO Jenny Hoff Fund David A. Antal D-B-A The Big G Foundation Benjamin Ahles ASD Foundation Darin De Angeli Corey Reich Fund Atlanta Circulation HMS Host Fund Aquesta Bank Dennis Coogle Fund Steven Bauersachs Linda Bauersachs Fund Mark Bello Oakland Activities Association David and Janie Berg Michael Winston Research Fund Ruthann Brazill Corey Reich Fund Dennis and Patricia-Ann Bourassa Bourassa Fund Frederic and Marie Carter Corey Reich Fund Bronx-Lebanon Hospital Center Corey Reich Fund Charitable Gift Fund ALS TDI Edward Bucciarelli Corey Reich Fund Darryl Christner Stanfield Family ALS Research Fund Robert and Alice Butler Family Charitable Founda Jennifer Nichols Mary Cirafice HMS Host Fund Peter Colichidas Peter Colichidas Fund

2009 ALS TDI Annual Report | 9 Research Advocate ($2500+) continued Research Sponsor ($1000+) Name Fund Name Fund Citrus World Inc HMS Host Fund A Small Miracle Inc Don Koenig Fund Neil Clark Paul and Janet Abramson Lee Abramson-Ace Noface Fund R Conner Corey Reich Fund ACN Inc Dennis Coogle Fund Guy DeRosa Stuart Adelman Michael Winston Research Fund Randy Craft Corey Reich Fund Edward Ahrens Corey Reich Fund Diageo North America Inc. LS TDI Golf Denise Allen Corey Reich Fund Jack and Sheila Doyle Dick Douglass Effort Alexander Aronson Finning & CO Kirk Dulany Bob Beshara Fund Amboy David and Anna Elefant Corey Reich Fund American Beverage Marketers HMS Host Fund M.D. and Marisa Emerson Corey Reich Fund Amparo Garcia-Capelo First Baptist Church of Mayodan NC Devona Sands Fund Memorial Michael and Jean Artin Stephen Heywood Fund Joe Florenzano Michael Winston Research Fund Association Management Inc Marie Garratt Memorial Fund Carol Foy Marie Garratt Memorial Fund Thomas and Mary Austin ALS TDI Golf Todd & Judy Freeman Michael Winston Research Fund Alissa Bachner Corey Reich Fund Sbarro Franchise HMS Host Fund Bailey Law Group HMS Host Fund Garner Environmental Services Stanfield Family ALS Research Fund Patricia Bailey Northeast Fund Julie Graves Balasa Dinverno and Foltz LLC Friends for Faye Fund Jim Heeter David Deitch Fund Steve and Wendy Baldinger Michael Winston Research Fund HMS Host Bank of America Matching Gifts Program Jeff Cronon Fund Jean Inman Phil Kramer Fund Bank Of America Merril Lynch John R. Lyman Company Anthony Tucker Fund Brett and Patricia Barakett Foundation Ride for Roger Phil and Lisa Johnstone Hope for Heidi John and Michelle Barrie Corey Reich Fund Sonia Kashuk Michael Winston Research Fund Barretti Family Barretti Family Fund Kevin Keane Dallas ALS Fund Paul Benenson Michael Winston Research Fund Kents Hill School Steven Berger and Paula Hughmanick Corey Reich Fund Jody Kevett HMS Host Fund Russell Berndt Phil Kramer Fund Anthony & Randee Killeen Michael Winston Research Fund Terry Blete Corey Reich Fund Konica Minolta Business Solutions U.S.A. Inc Rick Bowling Fund Christine and Sim Bohar Corey Reich Fund Dave Lafferty HMS Host Fund James and Debra Bomberg Michael Winston Research Fund Patricia Laus Pam Callahan Fund Bomberg, Roach and Hanson Michael Winston Research Fund Steven Lear Michael Winston Research Fund Bonita Bay Club ALS TDI Golf James Lee Dallas ALS Fund Boston Valley Terra Cotta Patricia Lee Corey Reich Fund Ross Bowen Lipsitz Green Scime Cambria Margaret Roblin Fund John and Amy Bowles Lawrence Foundation Little Dog Publications Raymond Bowman Marie Garratt Memorial Fund Jo Anne Lopatin Friends for Faye Fund Karl Brand Pam Callahan Fund Paulette Mariano Corey Reich Fund Brightpoint North America Phil Kramer Fund Travis McKibbin Dallas ALS Fund Richard Brodkin and Lois Buerkle Brodkin Team Gey Morgan Stanley Foundation Misc. FFC Events Alexander Bromley Motts Llp HMS Host Fund Brookfield Kiwanis Club Steve Carpenter Fund Kevin Mullen Michael Winston Research Fund Christopher Brown Jeff Hadley Fund McCain Foods USA Inc HMS Host Fund Burkhart Advertising Inc Friends for Faye Fund Nicks Tomatoe Pie HMS Host Fund Steve Byrd Brian Byrd Fund Paul Nugent Corey Reich Fund Kevin and Cindi Callahan Corey Reich Fund George Oconnell HMS Host Fund Thomas Callahan Odwalla Martin and Esther Capp of The Saint Paul Foundation Michael Winston Research Fund John Onstott HMS Host Fund Ana Casals Stanfield Family ALS Research Fund Margaret Paroski Margaret Roblin Fund Ryan Choi Corey Reich Fund PatientsLikeMe Inc. Dean and Suzanne Christensen Richard Portewig Corey Reich Fund Carol Christensen Margaret Roblin Fund Susan Powell HMS Host Fund Kabir Chuttani Marie Garratt Memorial Fund Garret Reed HMS Host Fund Clark County Association of Health Underwriters David Deitch Fund Radiology INC Foundation Friends for Faye Fund Robert Clausen Friends for Faye Fund Rudolph and Laurie Reich Corey Reich Fund John Clippinger Tom and Brigitte Reich Corey Reich Fund Barabara Cohen Corey Reich Fund Pernod Ricard HMS Host Fund Drs Coleman & Muldoon Dennis Coogle Fund Sarah Romanow Corey Reich Fund William Collier III Mike and Kristen Rone Michael Winston Research Fund Copeland Construction Meridiths Fight 4 Life Fund Samuel & Rachel Rosen Michael Winston Research Fund Robert Cox Roura and Melamed Attorney’s at Law David Coye David Green Fund Ronald Sacco ALS TDI Golf Raymond M and Jane E Cracchiolo Foundation Mary Lou Krauseneck Fund Chelsea Shaw HMS Host Fund Sand Creek Rubin Kuznitsky Fund Brian and Janine Stanfield Stanfield Family ALS Research Fund Crown Imports Michael Stern Michael Winston Research Fund CSJM Architects Incorporated HMS Host Fund Alain Sunier Corey Reich Fund Daniel Dalye The Delta Interests LLC Christy Sloan Fund Dan Berry Insurance Agency Inc. Friends for Faye Fund Bratten Thomason Christy Sloan Fund George Danko Michael Winston Research Fund Try It Distributing Co. Margaret Roblin Fund Kathleen Davis ALS TDI Golf University of Pittsburgh Medical Center Robert Dejoy Corey Reich Fund Us Foodservice Dell Direct Giving Campaign USA Roofing Dallas ALS Fund Kevin and Cathy DiLorenzo Michael Winston Research Fund Warner Bros. Entertainment Inc Steve Greenspan Fund Liliana Dimitri ALS TDI Golf Frederick and Elizabeth Weaver Marie Garratt Memorial Fund Disney Worlwide Outreach Peter Catucci Fund Westin Hotels And Resorts Ralph and Barbara Dobson Friends for Faye Fund Jeffrey and Mona Winston Michael Winston Research Fund Stephen and Pam Douglass Dick Douglass Effort Valero Energy Foundation Robert and Vivian Donato Jeff Vernier Dallas ALS Fund Nancy Dowd Matt Dowd Fund Michael Zinovoy HMS Host Fund Rock Doyle Margaret Roblin Fund

10 | ALS TDI Annual Report 2009 Research Sponsor ($1000+) continued Research Sponsor ($1000+) continued Name Fund Name Fund

Pat and Jenny Dwyer Facebook West Kirkland & Ellis Foundation Charles Hackney Fund ECF Employee Christmas Fund Stuart and Anne Knowles Corey Reich Fund Endo Pharmaceuticals Gary Kokin Margaret Roblin Fund Eric Engdahl Team Shelia Michael Krikoian Pam Callahan Fund Erie County Medical Center Margaret Roblin Fund Rubin Kuznitsky Ruben Kuznitsky Fund Edith Fenton Stephen Heywood Fund Edgard and Florence Leslie Charitable Trust Anthony Tucker Fund William Faradie Leighton Oare Foundation Friends for Faye Fund Stephen Ferretti McDaid Fund Bob and Mary Leisure Mary Lou Krauseneck Edouard De La Tour D’Auvergne Herb Schwartz Fund Rosa Lee de Leuze Michael Farrell Dino Leva Corey Reich Fund Robert Fink Corey Reich Fund Edward Levy Friends for Faye Fund FJMCD LLC Friends for Faye Fund Liberty KiA Bob Flinn Corey Reich Fund Mary Liebman Jenny Stoddard Fund David Fonvielle Team Gey James Lilly Corey Reich Fund Robert and Dorothy Frassetto Corey Reich Fund Mark Lilly Anthony Tucker Fund Alex Freda Lippes Mathias Wexler Margaret Roblin Fund Roger and Beverly Freeman Corey Reich Fund Gerald Lippes Margaret Roblin Fund Teak and Karen Freshour Mary Lou Krauseneck Lower Falls Wine Company Minervino Family Fund Glen and Robin Funjinaka Corey Reich Fund Sue Lund Michael Winston Research Fund Richard Garratt and Laurel Buccola Garratt Marie Garratt Memorial Fund Steve and Cynde Lundgren Corey Reich Fund GE Foundation Theodore Lustin Sean Forrester Scott Fund Steve and Lisa Gerber Friends for Faye Fund Lyndon Haviland Company Richard Giffith Corey Reich Fund M Medved Co Inc Cheryl Gilbert HMS Host Fund Cathy Magill Steve Carpenter Fund Esther Gillman Michael Winston Research Fund Sharon Makowsky Michael Winston Research Fund Steve Gilmour Corey Reich Fund Natalie Mallinckrodt Corey Reich Fund Joseph Gimilaro Peter Catucci Fund Mark Mandeville Stanfield Family ALS Research Fund Wayne Gimlin Dallas ALS Fund Marcus Realty Friends for Faye Fund Lou and Celia Star Gody Wolfmom Family Fund Peter Mark and Lynn Goldsmith Michael Goldsmith Fund Jane Gomprecht Corey Reich Fund Markstein Beverage Co Corey Reich Fund Kathleen Gomprecht Corey Reich Fund Dan and Cristin Marposon Salzarulo Fund Goodrich Foundation Martin Family Trust ALS TDI Golf Grace Episcopal Church Newton Stephen Heywood Fund Scott Matula Margaret Cullen Fund Alison Greenspan Steve Greenspan Fund Memorial Home Care Friends for Faye Fund Ann Greenspan Steve Greenspan Fund Merrill Lynch Trust Company Groupe le Duff Amerique Societe en Commandite HMS Host Fund Meuse Family Foundation Frank Hable Unsolicited Meyers Printing Michael Winston Research Fun Bruce Hain Stephen Heywood Fund J.N and C.A. McConell Marie Garratt Memorial Fund Seung Sook Han Sandra McCoy Marie Garratt Memorial Fund Eryn Harrison Corey Reich Fund James McKibbin Dallas ALS Fund Scott Harshman Corey Reich Fund Barbara McMillan Michael Winston Research Fund Christopher and Anja Hart Corey Reich Fund Roderick McRae ALS TDI Golf Terri Hathaway Stanfield Family ALS Research Fund Michiana Hermotology Oncology Medved Fund Brad Heckenkemper Stanfield Family ALS Research Fund Mile High United Way James Hettrick Margaret Roblin Fund Arthur Miller Marie Garratt Memorial Fund Benjamin Heywood Stephen Heywood Fund Robins Kaplan Miller & Ciresi Michael Winston Research Fund James Allen Heywood Stephen Heywood Fund John and Kathryn Milligan John and Peggy Heywood Stephen Heywood Fund Minervino Limited Partnership Marguerite Heywood Stephen Heywood Fund Chris and Deborah Minervino ALS TDI Golf Donald Hilburn Francisco and Karin Montoya Cynthia Hill Unsolicited Christopher Moore John Wake Fund Kent Hill Dick Sanderson Edward and Barbara Morgan HMS Host Invitational ALS TDI Golf Joshua Morgan Corey Reich Fund Hodgson Russ LLP Margaret Roblin Fund Murad Auctions Dallas ALS Fund David Holl Dallas ALS Fund Pamela Murphy Gordon Holmes Jack and Zelie Myers Corey Reich Fund Jo-Ann Hornyak Catherine Nathan Mark Howerton Ron Warren Fund Nephrology Inc Friends for Faye Fund HP Company Foundation New Jersey State Troopers HSBC Philanthropic Programs New York Breeders’ Sales Co Inc Imiagency HMS Host Fund Lenny & Terry Newman Michael Winston Research Fund Indiana State Seniors Golf Assoc ALS TDI Golf JuAnne Ng Innovative Concept Group Inc HMS Host Fund Gregory Norwood Dennis Coogle Fund Spiros Jamas Stephen Heywood Fund Michael Nugent Corey Reich Fund Jennie O Turkey Store Inc HMS Host Fund Martin O’Connor Mary Lou Krauseneck Bill Jennings Phil Kramer Fund Ogletree, Deakins, Nash, Smoak & Stewart, PC Herb Schwartz Fund Mark and Patricia Jennings Phil Kramer Fund Jonathan Orloff Walt Jennings Phil Kramer Fund Reed Oslan Charles Hackney Fund Violet Jones-Medusky 4uALS Major League Baseball West Aldo and Sandra Papone Mark Judd Margaret Roblin Fund Hugo Paredes Herb Schwartz Fund Ronald and Judy Kaecker Jan Monier Fund Scott Parkenson Christy Sloan Fund Kaleida Health Margaret Roblin Fund Betty A Payne Payne Family Fund Marybeth Kavanagh Marie Garratt Memorial Fund Michael Pennington Phil Kramer Fund Thomas Keating Corey Reich Fund Phoenix Rehabilitation & Health Ken S Foods Inc John Perry Meridiths Fight 4 Life Fund James King HMS Host Fund Piedmont High School Boosters Corey Reich Fund Tom King The 2130 New York Scott Plank and Dana DiCarlo Plank

2009 ALS TDI Annual Report | 11 Research Sponsor ($1000+) continued Research Sponsor ($1000+) continued Name Fund Name Fund Jeanette Pollion Stephen Heywood Fund The ADCO Group Corey Reich Fund Lee Poquette HMS Host Fund The Bean Counter William and Sandra Porter Stanfield Family ALS Research Fund The Great American Bagel Enterprises Inc Jacquelin Portewig Corey Reich Fund The Law Offices of Fischer Garon Hoyumpa & Rancilio Mary Lou Krauseneck Fund Colby and Julia Powell The Lobster Shack at Two Light Premier Breaverage Compagny LLC HMS Host Fund The Wanderers Club Aric Press Michael Goldsmith Fund The Wasserstrom Company HMS Host Fund Pulmonary & Critical Care Assoc., PC Friends for Faye Fund The Wigand Family Natalie Ramier Michael Winston Research Fund Chris and Anne Thorsen Corey Reich Fund Rampart Casino David Deitch Fund David Thysen and Beverly Rees Ryan Randall Russell and Christine Tippett Jenny Stoddard Fund Rhonda Real Dallas ALS Fund Trump National Golf Club Regina Rear Connor Dunphy Sisters’ Fund UBS Financial Services R.E.E. Consulting, LLC University at Buffalo Neurosurgery Margaret Roblin Fund Red Letter Holdings Dennis Coogle Fund Fyllis Unowsky Michael Winston Research Fund John Redden Memorial Utah Society for Respiratory Care Stephen Reich Corey Reich Fund Vanguard Charitable Endowment Program Reichert Foundation ALS TDI Golf John Vazzana Manhattan Fund Jean Relyea Salzarulo Fund Rene Vergez ALS TDI Golf Kenneth Renko HMS Host Fund Christine Virden Team Virden Daniel Richenthal James Voyles ALS TDI Golf Sandra Riffe Dallas ALS Fund Michael Wachtell Marcia Wachtell Fund Risser Endodontics PC Friends for Faye Fund Michael Wallace Phil Kramer Fund Tom Ritchie Stanfield Family ALS Research Fund Robert and Joan Wallace Gerald Robbins Bryan Walsh Phil Kramer Fund Paul Rockar Rick Bowling Fund Wellesley College Robert Rodin Sean Forrester Scott Fund Mike Weston The 2130 New York Neil Rothenberg Corey Reich Fund Tim Whelan HMS Host Fund Richard Rosenfeld Eric and Amy Whipple Mary Lou Krauseneck Matthew and Cathy Rosing Marie Garratt Memorial Fund Dorothy Wiekamp Friends for Faye Fund Jim Rossi Team Gey Fund Bethany Williams Ann Rouse Peter and Ellen Wilson Corey Reich Fund Ruth Anne Rubenstein Robert and Loretta Wolf ALS TDI Golf Challenge Mike and Geri Rubenstein Frank J. Wood Rudder Restaurant Attaya-Boland Samuel Woodworth ALS TDI Golf Robert Sadlemire and Mary Kay Boudewyns Jeff Hadley Fund Brian Wruble Stephen Heywood Fund Santa Fe Community Foundation Linda Yahner Carmine Sarno Corey Reich Fund Yogurt Ventures USA Inc HMS Host Fund Thomas Seiffert and Faye Magneson Friends for Faye Fund ZD Wines Corey Reich Fund Sca Tissue North America HMS Host Fund Michael Zibby Lee Blaskovich Fund Steven & Nancy Schachtman Michael Winston Research Fund Bob and Cynthia Schuneman Stephen Heywood Schwab Charitable Fund Michael Sedlak Corey Reich Fund John Shutack Silver Shield Association Ride for Roger Alvin Siteman Friends for Faye Fund Sitzmann, Morris and Lavis Corey Reich Fund Alicia Skodol Lee Blaskovich Fund Jacklyn Smith Michael Winston Research Fund Michael & Shelli Smith Michael Winston Research Fund Molly Smith Steve Greenspan Fund Paul Smith HMS Host Fund Irene Snow Margaret Roblin Fund Steve and Anne Sommer Corey Reich Fund South Bend Warehouse and Distribution Corporation Friends for Faye Fund Micheal Spieth Marie Garratt Memorial Fund Joe Spoo Scott Stafne ALS Research Fund Sports Auctions For Charity Richard and Janet Srague Stephen Heywood Fund ALS TDI has become one of the St Philip The Apostle Catholic Church David Staley Corey Reich Fund world foremost innovators in Shane Stark Dan Dowson Dobber Up Startifacts Michael Winston Research Fund research and development of Robert and Sonya Stevanovki Craig Steward potential treatments for ALS. Lorrie Stonacek 4uALS Awareness Christian Storm Corey Reich Fund We still believe that a treatment Beth Strackell Dallas ALS Fund John Sullivan for ALS is not only possible, but Sun’n Fun Fly-in Inc. Marie Garratt Memorial Fund Suntrust Foundation Peter Catucci Fund inevitable. T.A.S. Environmental Services Linda Tatu Margaret Roblin Fund Michael and Judith Tavill Pam Callahan Fund Tracy Taylor Phil Kramer Fund

12 | ALS TDI Annual Report 2009 2009: ALS TDI 00846 IDENTIFIED, INSTITUTE BEGINS PARTNERING PROCESS

For the fiscal year ending December 31, 2009, ALS TDI recognized more than $9.3 million in public support and unrestricted revenue. OVER THE PAST TEN YEARS, ALS TDI HAS RAISED MORE THAN $60 MILLION FOR RESEARCH, 1/3 OF WHICH HAS BEEN DONATED IN THE LAST TWO YEARS ALONE. In 2009, nearly two hundred fundraising events took place in support of our research, buoyed by nearly one hundred July 4th BBQ events held in partnership with Major League Baseball 4uALS Awareness Program. A full-break down of our assets, liabilities, revenue and expenses is below.

Assets Expenses Cash 3,829,175 Program Accounts and Pledges 115 R&D Prepaid Exp. 73,944 Science 2,613,109 Investments 2,107 Lab 2,291,975 Fixed 607,790 Informatics 291,657 Other 41,167 Patient Services 441,290 Clinical 23,035 Total $4,554,298 Communications 892,480

BD 234,000 Total Program $6,787,546 Liabilities & Net

Total L 661,641 Support Total NA 3,892,657 General 795,525 Total Unrestricted $4,554,298 Fundraising 685,821 Total Support $1,481,346

Public Support Total Expenses $8,268,892 Grants 7,377,500 Special 1,411,263 General 249,949 Donated 273,518 Interest 48,591

Net Public $9,360,821

2009 ALS TDI Annual Report | 13 20,000 DONATIONS, 300 FAMILY FUNDS, 200 GRASSROOTS EVENTS – 1 GOAL

While 2009 may have been one of the most challenging fundraising years for many organizations, ALS TDI held strong thanks to the commitment and determination of the ALS community to fund their own brick-and-mortar research institute. MORE THAN 300 FAMILY FUNDS FUEL OUR RESEARCH. THEIR COMBINED EFFORTS LED TO NEARLY 20,000 INDIVIDUAL DONATIONS IN 2009.

The graph below depicts the total spending and percentage of total expenses for the various categories reported on each year. The Institute’s finances are in a strong position with reserves at their highest point since the foundation was created, allowing for long-term and strategic investments and planning to advance more potential therapeutics from the lab bench to the bedside quicker than ever before. THIS KEY ADDITIONAL FUNDING WILL ENABLE MORE NOVEL THERAPEUTIC CANDIDATES TO MOVE FROM THE PRECLINICAL PIPELINE INTO THE PARTNERING AND CLINICAL TRIAL PHASES OF DEVELOPMENT.

Expenses 2009 Program Amount Ratio

R&D Science 2,613,109 31.60% Lab 2,291,975 27.72% Informatics 291,657 3.53% Patient Services 441,290 5.34% Clinical 23,035 0.28% Communications 892,480 10.79% BD 234,000 2.83% Total Program $6,787,546 82.09%

Support

General 795,525 9.62% Fundraising 685,821 8.29%

Total Support $1,481,346 17.91%

Total Expenses $8,268,892 100.00%

14 | ALS TDI Annual Report 2009

215 First Street, Cambridge, Massachusetts 02142 TEL: 617.441.7200 FAX: 617.441.7299 EMAIL: [email protected] WEB: www.als.net