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Carditis: Inside and Out

Derek Brown, MD SAUSHEC Military EMS & Disaster Medicine Fellow

Bruce Blaus https://commons.wikimedia.org/wiki/File:Pericarditis.png Pericarditis

0.1% of Hospitalized Patients 5% of ED Patients with non-ACS CP

80-90% Viral

Complications: 21% Patients 18% recurrence 3-5% tamponade 2% constrictive pericarditis Pericarditis

Not ACS

Not Tamponade

Not Pericarditis ECG

James Heilman, MD https://commons.wikimedia.org/wiki/File:PericarditisMyocarditis.jpg Pericarditis STEMI Tamponade Pericarditis vs Myocarditis

Pericarditis – 70% cases – 25% cases Perimyocarditis – 5% cases

Troponin Elevation: Ventricular Failure Reduced LVEF High Risk Features >38°C (100.4° F) Subacute Course (several days – weeks) Large (end- Echo-free space >20mm) Immunosuppression / Immunocompromised Anticoagulation Use Trauma Failure of NSAID and/or Elevated Myocarditis

Variable Presentation: Viral Illness Cardiogenic Shock

41 – 89% Viral Prodrome

Enterovirus, Adenovirus, Parvo B19, HHV 6

Severe Myocarditis 5yr Survival: 56% Pediatric: 90% with 80% requiring ICU care Myocarditis Presentation

Pediatric Series: Key Features: 45% - EKG Changes of Myocardial 28% Resp. Distress 27% GI Sx - Rise in Troponin 16% Poor Perfusion - 41% Viral Prodrome - New/Unexplained Cardiac Dysfxn

- Out-Of-Proportion Emergency Management

Pediatric Series: 45% Significant Arrhythmia

Frank Gaillard https://commons.wikimedia.org/wiki/File:AP_portable_CXR_of_a_patient_in_acu te_pulmonary_oedema.jpg Cardiogenic Shock

Broad Differential Inotropes Mechanis Effect Adverse m Trial of IV Fluid Dobutamine Inodilator ↑Contract ↓SVR Milrinone Inodilator ↑Contract ↓SVR Hypotension Inotropes Dopamine Mixed ↑Contract ↑↓SVR Arrhythmia, ↑ Mortality Norepinephrine Inopressor ↑Contract ↑SVR Positive Pressure Epinephrine Inopressor ↑Contract ↑SVR Tachycardia, Arrhythmia & Invasive Ventilation

Mechanical Circulatory Support Regional Care System References:

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Kytö, V., Sipilä, J., & Rautava, P. (2014). Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis CLINICAL PERSPECTIVE. Circulation, 130(18), 1601-1606. - 5% hosp pts

Levy, B., Perez, P., Perny, J., Thivilier, C., & Gerard, A. (2011). Comparison of norepinephrine-dobutamine to epinephrine for , lactate , and organ function variables in cardiogenic shock. A prospective, randomized pilot study. Critical care medicine, 39(3), 450-455.

Mason JW, O'Connell JB, Herskowitz A, et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N Engl J Med 1995; 333:269.

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Rossello, X., et al. (2014). New electrocardiographic criteria to differentiate acute pericarditis and . The American journal of medicine, 127(3), 233-239. van Diepen, S., Katz, J. N., Albert, N. M., Henry, T. D., Jacobs, A. K., Kapur, N. K., ... & Thiele, H. (2017). Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation, 136(16), e232-e268.