Optimizing Breast Reconstruction After Mastectomy University of Antwerp Faculty of Medicine and Health Sciences
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Optimizing breast reconstruction after mastectomy mastectomy after reconstruction Optimizing breast Filip Thiessen University of Antwerp Faculty of Medicine and Health Sciences Optimizing breast reconstruction after mastectomy The use of dynamic infrared thermography Filip THIESSEN 2020 Antwerp, 2020 Thesis submitted in fulfilment of Promoters: Prof. dr. Wiebren Tjalma the requirements for the degree of Prof. dr. Gunther Steenackers Doctor in Medical Sciences at the Prof. dr. Guy Hubens University of Antwerp Co-promoter: Prof. dr. Veronique Verhoeven University of Antwerp Faculty of Medicine and Health Sciences Optimizing breast reconstruction after mastectomy: The use of dynamic infrared thermography Optimaliseren van borstreconstructies na mastectomie: Het gebruik van dynamic infrared thermography Thesis submitted in fulfilment of the requirements for the degree of Doctor in Medical Sciences at the University of Antwerp to be defended by Filip THIESSEN Proefschrift voorgelegd tot het behalen van de graad van doctor in de Medische Wetenschappen aan de Universiteit Antwerpen te verdedigen door Antwerpen, 2020 Promotoren: Prof. dr. Wiebren Tjalma Prof. dr. Gunther Steenackers Prof. dr. Guy Hubens Begeleider: Prof. dr. Veronique Verhoeven Promotoren Prof. dr. Wiebren Tjalma Prof. dr. Gunther Steenackers Prof. dr. Guy Hubens Begeleider Prof. dr. Veronique Verhoeven Members of the jury Internal Prof. dr. Jeroen Hendriks Prof. dr. Manon Huizing Prof. dr. Wiebren Tjalma Prof. dr. Gunther Steenackers Prof. dr. Guy Hubens External Prof. dr. Emiel Rutgers Prof. dr. Assaf Zeltzer © Filip Thiessen Optimizing breast reconstruction after mastectomy: The use of dynamic infrared thermography / Filip Thiessen Faculteit Geneeskunde, Universiteit Antwerpen, Antwerpen 2020 Thesis Universiteit Antwerpen – with summary in Dutch Lay-out and cover : Dirk De Weerdt (www.ddwdesign.be) Cover figure: Cold challenge to bilateral DIEP in skin sparing mastectomy (top), rapid and overall rewarming of the skin islands of the DIEP flap (bottom). Table of contents List of abbreviations 5 General introduction 7 Aims and outline 17 Chapter 1. Breast reconstruction 21 Part A: Breast reconstruction after breast conservation therapy for breast cancer 23 Part B: Breast reconstruction after mastectomy 37 Chapter 2. The evolution of breast reconstructions with free flaps: a historical overview 51 Chapter 3. Dynamic infrared thermography (DIRT) in DIEP flap breast reconstruction: a review of the literature 71 Chapter 4. Dynamic infrared thermography (DIRT) in DIEP flap breast reconstruction: standardization of the measurement set-up 91 Chapter 5. Dynamic infrared thermography (DIRT): clinical studies 105 Part A: DIEP flap breast reconstructions: thermographic assistance as a possibility for perforator mapping and improvement of DIEP flap quality 107 Part B: Dynamic infrared thermography (DIRT) in DIEP flap breast reconstruction: a clinical study with a standardized measurement setup 131 General discussion 149 Summary 161 Samenvatting 165 Curriculum vitae 169 Dankwoord 181 A detailed table of contents is given at the start of each chapter List of abbreviations ADM: Acellular Dermal Matrix ALT: Antero Lateral Thigh flap BCT: Breast Conserving/Conservation Therapy CDU: Colour Doppler Ultrasound CTA: Computed Tomography Angiography DCIA: Deep Circumflex Iliac Artery flap DCIS: Ductal carcinoma in situ DIEaP/DIEP: Deep Inferior Epigastric artery Perforator flap DIRT: Dynamic Infrared Thermography DUG: Diagonal Upper Gracilis flap FCI: Fasciocutaneous Infragluteal flap HP: High Profile ICG: Indo-Cyanine Green IGAP: Inferior Gluteal Artery Perforator flap IR: InfraRed IV: Intravenous LAP: Lumbar Artery Perforator flap LD: Latissimus Dorsi flap LICAP: Lateral Intercostal Artery Perforator flap LTP: Lateral Thigh Perforator flap MP: Moderate Profile MRA: Magnetic Resonance Angiography MRI: Magnetic Resonance Imaging MS-TRAM: Muscle Sparing Transverse Rectus Abdominis Myocutaneous flap NSM: Nipple Sparing Mastectomy NNSM: Non Nipple Sparing Mastectomy PAP: Profunda Artery Perforator flap PFAP: Profunda Femoris Artery Perforator flap PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analysis QOL: Quality of Life SGAP: Superior Gluteal Artery Perforator flap SIEA: Superficial Inferior Epigastric Artery flap TDAP: Thoracodorsal Artery Perforator flap (Sc-)TFL: (Septocutaneous) Tensor Fascia Lata flap TMG: Transverse Myocutaneous Gracilis flap TRAM: Transverse Rectus Abdominis Myocutaneous flap TUG: Transverse Upper Gracilis flap VUG: Vertical Upper Gracilis flap 5 General introduction Contents Breast cancer 9 Breast cancer reconstruction 9 Dynamic infrared thermography 11 References 15 Aims 18 Outline 19 References 20 General introduction Breast cancer reast cancer is the most common cancer in women worldwide with more than two million new cases in 2018 [1]. The country with the highest incidence rates of breast cancer in the world is Belgium with age-standardized cancer index of 113.2 per B100.000 females, which totals to around 11,000 women each year [2]. Breast cancer reconstruction The treatment of breast cancer often involves a mastectomy as part of the therapy. One out of 7 patients undergoes a breast reconstruction after mastectomy. Half of which are performed with autologous tissue. Thirty- two percent of the autologous tissue flaps are Deep Inferior Epigastric Perforator (DIEP)-flaps [3]. Reconstruction following mastectomy offers women an opportunity to soften some of the emotional and aesthetic ef- fects of this disease. Autologous tissue breast reconstruction remains the technique associated with the highest patient satisfaction and represents preferred technique for recreation of the breast [4, 5]. Breast reconstruc- tions with perforator flaps from the lower abdomen, Deep Inferior Epigas- tric artery Perforator flap (DIEP-flap), have become the gold standard for autologous breast reconstruction after breast amputation. The abdominal donor site remains unmatched in breast reconstruction for its volume, color and texture resemblance with native breast tissue and for its potency to match a ptotic opposite breast that tends to age in a natural fashion [6, 7]. The skin and subcutaneous tissue from the patient’s lower abdomen are transplanted as a free flap to the thorax to reconstruct the patient’s breast. The flap is perfused from the deep inferior epigastric artery and one or two concomitant veins through a perforator. In DIEP-flap breast recon- struction, the blood supply to the flap is re-established by anastomosing the deep inferior epigastric artery and vein to the internal mammary artery and vein. (Figure 0.1) 9 General introduction The selected perforator is the only source of blood supply to the flap. Selection of the best perforators is of uttermost importance in this proce- dure. This will reduce operative time, lower complication rates and ensure an overall better result. There are a number of methods of locating per- forating vessels in the flap, such as Computer Tomography Angiography (CTA), Color Doppler ultrasound (CDU), Magnetic resonance Angiography (MRA) or Dynamic Infrared Thermography (DIRT) [8, 9]. The current gold standard for perforator selection is CTA. on which the location and hemo- dynamic properties of the flap can be reviewed [8, 10]. In order to be considered ideal in clinical conditions, a method should meet the following conditions: non-invasive, simple, repeatable, intra-op- erative assessment and low cost. DIRT can be an alternative. DIRT uses an Infrared (IR) camera to measure the skin temperature based on heat emit- ted by tissues. This generates a color-coded map, which is a translation for the skin perfusion. Figure 0.1. Schematic drawing of DIEP flap (credits KS). 10 General introduction Dynamic infrared thermography The human body tries to maintain a constant temperature that is dif- ferent from the surroundings. This is possible thanks to an equilibrium of all systems within the human body, which leads to dynamic changes in heat emission. The heat is transported through the body by the circulat- ing blood. Heat loss from the skin to the environment is possible by con- duction, convection, evaporation and radiation (Figure 0.2). The principal mechanism under stable conditions (18°C to 25°C) to achieve an equilib- rium is radiative heat loss from the skin to the environment. This radiative heat loss takes places in the form of infrared (IR) radiation [11, 12]. In medical IR thermography the body surface temperature is measured with the use of an IR camera. Colour-coded maps are created that visual- ize the vascular perfusion of the skin (Figure 0.3). In most cases, a rainbow Figure 0.2. Heat loss adapted from De Weerd et al.[11]. 11 General introduction palette is used for infrared-thermography [11]. Despite its popularity these colored maps have not shown to be superior to the grayscale map due to the fact that the human visual system is more sensitive to changes in lumi- nance [13]. Studies have shown a good correlation between skin tempera- ture and skin perfusion. Measurement of skin temperature can therefore provide information of skin perfusion [11, 14]. Already in the 1950’s IR thermography was used as medical diagnostic tool in breast cancer [15]. Due to the low sensitivity of the early cameras Figure 0.3. In medical IR thermography the body surface temperature is measured with the use of an IR camera. Colour-coded maps are created that visualize the vascular perfusion of the skin. Before microsurgi-