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What Are Good Ways to Address the Shortage of Face Masks by Anesthesiologists?

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What Are Good Ways to Address the Shortage of Face Masks by Anesthesiologists? COVID-19 Evidence Service | Addressing COVID-19 Face Mask Shortages [v1.1] Updated March 22, 2020 Please note: We do not advocate or advise specific treatments or approaches. The COVID-19 Evidence Service aims to share the best available evidence to address questions for clinical anesthesiologists and the anesthesiology community. We recommend that hospital policy and procedures be respected and adhered to. What are good ways to address the shortage of face masks by anesthesiologists? Stanford Learnly Anesthesiologist Amy Price, DPhil (Oxon) and Larry Chu, MD On behalf of the Stanford AIM Lab and Learnly COVID-19 Evidence Service Stanford Anesthesia Informatics and Media Lab Learnly Anesthesia Learning Ecosystem Correspondence to [email protected] KEY TAKEAWAYS • Frontline health care workers across the United States report shortages of PPE ranging from gloves, protective gowns, eye wear and face masks. • It is unknown how wearing the same mask multiple times effects the fit of N95 masks [NIOSH] • NIOSH states “there is no way of determining the maximum possible number of safe reuses for an N95 respirator as a generic number to be applied in all cases” and advise to “discard N95 respirators following use during aerosol generating procedures.” • Some methods of N95 mask disinfection can maintain filtration efficiency. Their effect on mask fit is unknown, and these methods are not approved by NIOSH. Learnly Anesthesia | Stanford AIM Lab COVID-19 Evidence Service Report RATIONALE The current COVID-19 pandemic has highlighted global supply chain shortcomings in the US hospital delivery system, most notably personal protective equipment (PPE). Frontline health care workers across the United States report shortages of PPE ranging from gloves, protective gowns, eye wear and face masks. The transmission of COVID-19 is thought to occur through respiratory droplets, and current CDC guidelines recommend the use of N95 masks for health care providers managing the care of patients infected with SARS-CoV-2 or persons under investigation (PUI) for COVID-19. The global shortage of PPE in the setting of a viral pandemic has created potentially dangerous conditions for frontline healthcare workers lacking appropriate protection and their patients. My hospital only provides N95 masks for PUI and COVID-19 positive patients. What is the chance that an asymptomatic person who has a negative COVID-19 history screening carries the SARS-CoV-2 virus? Based on that chance, is wearing an N95 mask for all patients undergoing endotracheal intubation warranted? In COVID-19, "50-75% of 3000 positive cases in Vo, Italy were asymptomatic according to Professor Sergio Romagnani. Risk of exposure grows exponentially as noted through actual exposures (charted internationally) N95 masks are warranted and remain the standard of care. While CDC has relaxed standards of care, their evidence cites risks of self-inoculation, cross contamination and pathogen spreading through direct and indirect transmission. CDC recommends Standard Precautions should be followed when caring for any patient, regardless of suspected or confirmed COVID-19. Doctors without borders report COVID-19 infected healthcare workers surge to 8% in Italy with 1700 healthcare workers infected and recent report suggest this is climbing to 8.3% where PPE shortages are widespread. Page 2 of 8 | What are good ways to address the shortage of face masks? Learnly Anesthesia | Stanford AIM Lab COVID-19 Evidence Service Report My hospital ran out of N95 and surgical masks. We want to make our own face masks from supplies we can purchase at local stores. What appropriate replacement materials are suitable for face masks when no PPE is available? UNKNOWN: Nurses and other health care providers can “use homemade masks (e.g., bandana, scarf) for care of patients with COVID-19,” according to CDC but in the next sentence admits protection capability is unknown. Alternatives are being fashioned from existing materials. Comparison study and graph where authors measured homemade mask ability to filter virus size particles. Table 1: *The mask effectiveness is offset by difficulty to breathe through the filter, vacuum bags were rated highly but the effort to breathe made it less secure. **Using inner filters such as feminine hygiene products for N95 masks is not recommended as N95 mask once contaminated retain 99.8% of pathogens ***Other materials such as teabags which are antimicrobial might be used or layered with other materials Page 3 of 8 | What is the best approach to address the shortage of face masks? Learnly Anesthesia | Stanford AIM Lab COVID-19 Evidence Service Report Links to consider if you have to make a mask https://www.consumer.org.hk/ws_en/news/specials/2020/mask-diy-tips.html https://time.com/5805557/homemade-medical-face-mask-shortage/ https://maidsailors.com/blog/how-to-make-a-surgical-mask/ Can N95 masks be reused multiple times and remain effective barrier protection for SARS- CoV-2? Although this process is used according to CDC when there are PPE shortages it is not safe and there is no high-level evidence to indicate this is safe. We could find no reassuring statistics released by the CDV or others during other pandemics to show this is practice is safe and the barrier protection is shown to deteriorate with use and time. Can N95 masks be autoclaved or sterilized by other means for safe reuse? To be useful a decontamination method must eliminate the viral threat, be harmless to end- users, and retain respirator integrity. N95 Mask UPDATE 4C Air confirmed all the proposed treatments have killed corona viruses. Labs have no way to test COVID-19 directly and as an accepted protocol, E. Coli is used for testing. We asked what methods can be used to decontaminate the facial mask for reuse safely and without loss to filtration efficiency. 4C Air confirms using 70 degree C hot air in an oven (typical kitchen-type of oven will do) for 30min, or hot water vapor are additional effective decontamination methods. Please see Table 2 Page 4 of 8 | What are good ways to address the shortage of face masks? Learnly Anesthesia | Stanford AIM Lab COVID-19 Evidence Service Report Can Facial Masks be Disinfected for Re-use? (Measurement results by 4C Air Inc.) Samples Meltblown fiber filtration Static-charged cotton E. Coli. media Disinfection Efficiency Filtration Pressure drop Filtration Pressure drop efficiency (%) (Pa) efficiency (%) (Pa) 70℃ hot air in oven, 96.60 8.00 70.16 4.67 >99% 30min UV light, 30min 95.50 7.00 77.72 6.00 >99% 75% alcohol, soaking 56.33 7.67 29.24 5.33 >99% and drying Chlorine-based 73.11 9.00 57.33 7.00 >99% disinfection, 5min Hot water vapor 94.74 8.00 77.65 7.00 >99% from boiling water, 10min Initial samples 96.76 8.33 78.01 5.33 before treatment Conclusions: DO NOT use alcohol and chlorine-based disinfection methods. These will remove the static charge in the microfibers in N95 facial masks, reducing filtration efficiency. In addition, chlorine also retains gas after de-contamination and these fumes may be harmful. Table 2: Data supplied courtesy of Professor Yi Cui | Materials Science and Engineering, Stanford University and Professor Steven Chu | Physics and Molecular & Cellular Physiology, Stanford University on behalf of 4C Air Incorporated. Viscusi and colleagues evaluated five decontamination methods for nine models of NIOSH- certified respirators (three models each of N95 FFRs, surgical N95 respirators, and P100 FFRs) N95 masks. They tested filtration performance and filter airflow resistance but not the viral threat. The five methods for decontamination were bleach, ethylene oxide (EtO), microwave oven irradiation, ultraviolet germicidal irradiation (UVGI), and hydrogen peroxide (vaporized and liquid forms). Filter aerosol penetration values were maintained for the five methods (less than the National Institute for Occupational Safety and Health (NIOSH) certification criteria). Authors found decontamination using an autoclave, 160C dry heat, 70% isopropyl alcohol, and soap and water (20-min soak) caused significant degradation to filtration efficiency. Airflow resistance remained constant except in the case of the masks melted by the microwave which obviously could not be tested. Lindsley et al, 2015 report material strength of N95s can degrade with UVGI. Page 5 of 8 | What is the best approach to address the shortage of face masks? Learnly Anesthesia | Stanford AIM Lab COVID-19 Evidence Service Report In summary bleach and microwaves were failures at point of care because the bleach gases (skin and respiratory irritants) remained after multiple strategies were used to remove them, the microwave melted the masks and soaking them first led to reduced filtration. EtO, UVGI, and hydrogen peroxide decontamination were safe and effective in the models tested but it is not known if they would retain filtration, material strength, and airflow integrity with repeated use. EtO, UVGI, and hydrogen peroxide limitations include time from decontamination to reuse and available space and materials to decontaminate in an OR setting. 70C /158F heating in a kitchen-type of oven for 30min, or hot water vapor from boiling water for 10 min, are additional effective decontamination methods. Can electrolyzed water kill SARS-CoV-2 and be used to treat PPE for reuse Electrolysed water EOW, ECA is produced by the electrolysis of water containing dissolved sodium chloride (salt). This electrolysis produces a slightly corrosive solution of hypochlorous acid and sodium hydroxide. The resulting water can be used as a disinfectant. It can kill some viruses in 5 seconds if used immediately and within 5 minutes if used within 48 hours of production. One challenge is that it weakens when it is in contact with proteins such as body fluids, like blood, mucous, stool or vomit. The other challenge is that at least one manufacturer will void the warranty if electrolysed water is used on their equipment due to corrosive activity.
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