Contents Sponsorship 45th Annual Meeting & ToxExpo™ 2006 Annual Meeting Sponsors ...... Inside Front Cover Program Overview ...... Front Foldout March 5–9, 2006 Sponsorship Opportunities & The Toxicologist on CD-ROM ...... Inside Back Cover
Events and Maps Career Resources and Development Event Calendar by Day & Time ...... 2 Career Resources and Development Services ...... 34 Event Calendar by Event Name ...... 7 San Diego Convention Center Map ...... 12 Social Functions San Diego Hotel Accommodations ...... 14 Social Events ...... 36 Downtown San Diego Map ...... 15 Manchester Grand Hyatt San Diego Map ...... 16 Award Winners Marriott San Diego Hotel & Marina Map ...... 18 2006 Award Winners ...... 37 San Diego Restaurants ...... 20 2005 Student Award Winners ...... 42
2006 ToxExpoTM ToxExpo™ Exhibit Hall Floorplan ...... 23 Sessions Index 2006 Exhibitors ...... 24 Scientific Sessions Index ...... 43 Registration Continuing Education Registration Information ...... 26 Continuing Education Courses ...... 49 General Information Program 45th Anniversary Raffle Contest ...... 27 Program Description ...... 57 Accessibility for Persons with Disabilities ...... 27 Author Index ...... 257 Attire ...... 27
Badges ...... 27 Business Center ...... 27
Exhibit Hall (Hours/Location) ...... 27 SOT Leadership First Aid ...... 27 2005–2006 Council ...... 280 Food Services ...... 27 Officers and Councilors ...... 282 Guest Hospitality Center and Program ...... 28 Past Presidents ...... 282 Housing Information and Reservations ...... 28 Elected Committees ...... 283 Internet Access and Electronic Devices ...... 29 Appointed Committees ...... 283 Lost and Found ...... 29 Officers—Specialty Sections ...... 287 Luggage Check ...... 29 Officers—Regional Chapters ...... 288 Media Support Services ...... 29 Memorabilia ...... 29 SOT References Message Center ...... 29 SOT Award Descriptions and History ...... 289 Photography Policy ...... 30 Toxicology Specialists ...... 298 Registration Desk Hours ...... 30 Headquarters Staff ...... 300 Safety and Security ...... 30 SOT Affiliates ...... 301 SOT Headquarters Office ...... 30 2007 Annual Meeting Session Proposal Information ...... 312 Speaker Ready Room ...... 30 Sponsorship ...... 31 Transportation ...... 31 Tour Information ...... 32 San Diego The Toxicologist/Itinerary Planner ...... 32 Weather ...... 32 CALIFORNIA
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Anniversary th
Annual Meeting Annual th icket Required) As of January 1, 2006 T Anniversary th March 5, 200 March March 4, 200 March March 3, 200 March SOT's 45 SOT's Anniverary (All Attendees Welcome) San Diego Convention Center Room 33 8:00 PM to 10:30 PM Arizona Night Marriott Hotel & Marina San Diego Ballroom A 8:00 PM to 10:00 PM IUTOX Executive Committee Dinner 8:00 PM to 9:00 PM Post-Doctoral Assembly Event (All Post-Docs Invited) San Diego Convention Center Room 32 5:15 PM to 6:30 PM San Diego Convention Center Room 6C 6:30 PM to 7:30 PM 45 San Diego Convention Center Sails Pavilion 6:45 PM to 7:15 PM San Diego Convention Center Room 14B 7:00 PM to 8:00 PM Celebrating 45 (By Invitation Only) San Diego Convention Center Room 4 7:30 PM to 9:30 PM Marriott Hotel & Marina Manchester Room 7:30 PM to 8:30 PM Student/Post-Doctoral Fellow Mixer to Attend— Awards Ceremony Celebrating 45 Awards Reception Celebrating Welcoming I Meeting Committee Advisory Student Reception Member More) (or 25–Year Employees for Reception Annual LRRI (All Attendees Welcome) (All Students and Post-Docs are Invited (All Students and Post-Docs are Top of the Market Restaurant Top Education Fellowship Interviews 6:15 PM to 9:00 PM Undergraduate Education Program Lecture & Reception San Diego Convention Center Room 16A 5:30 PM to 8:30 PM San Diego Convention Center Room 12 5:30 PM to 6:00 PM Undergraduate Education Program Orientation for Hosts, Peer Mentors, and Advisors San Diego Convention Center Room 19
Associate
Annual Annual th (Ticket Required) (Ticket Room 17B 4:00 PM to 5:15 PM San Diego Convention Center Room 3 4:45 PM to 5:15 PM Performance by San Diego University Choral Scholars (All Attendees Welcome) San Diego Convention Center Room 6C 11:00 AM to 3:00 PM Editors Meeting Marriott Hotel & Marina Cardiff Room 11:45 AM to 1:15 PM Continuing Education Luncheon for Speakers, Committee, and Students (By Invitation Only) San Diego Convention Center Room 4 12:00 NOON to 1:00 PM Marriott Hotel & Marina Encinitas Room 1:00 PM to 5:00 PM IUTOX Executive Committee Meeting I Marriott Hotel & Marina Del Mar Room 1:15 PM to 5:00 PM Continuing Education Courses San Diego Convention Center (See Signage for Room Locations) 3:00 PM to 5:00 PM Academic Program Session for Undergraduate Students San Diego Convention Center Awards Recipients Photographed Awards IUTOX Science Commission Meeting Commission Science IUTOX Toxicological Sciences Toxicological San Diego Convention Center Hall A Lobby Subject to Change) (Hours are 5:00 PM to 5:45 PM Continuing Education Committee Walk-Through San Diego Convention Center Room 5 4:00 PM to 7:00 PM SOT Office San Diego Convention Center Room 14A 4:00 PM to 7:00 PM Speaker Ready Room San Diego Convention Center Room 14A 4:00 PM to 7:00 PM Tour Desk Tour 45 2
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ADME ADME
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Set Up Explores the Genome: TM San Diego Natural History Museum Balboa Park Encinitas Room 9:00 AM to 11:30 AM Marriott Hotel & Marina Newport Beach Room 9:30 AM to 11:30 AM IUTOX Developing Countries Committee Meeting Marriott Hotel & Marina Encinitas Room 10:00 AM to 3:30 PM CRAD Job Bank Center (Registration Only) Marriott Hotel & Marina Leucadia Room 10:00 AM to 5:00 PM K–12 Committee Outreach Event— Paracelsus 8:00 AM to 5:00 PM San Diego Convention Center Exhibit Hall 8:00 AM to 5:00 PM Undergraduate Education Program Session San Diego Convention Center Room 16A 8:15 AM to 12:00 NOON Continuing Education Courses San Diego Convention Center (See Signage for Room Locations) 8:30 AM to 9:30 AM IUTOX Enhancement of the Appreciation and Image of Meeting Force Task Toxicology Marriott Hotel & Marina (Ticket Required) (Ticket Toxicology Education Foundation Education Foundation Toxicology Meeting Trustees Advances Health Toxicology (Public Invited—Free Admission for All) (Public Invited—Free ToxExpo Columbia Room Columbia HESI/SETAC HESI/SETAC Workshop Bioaccumulation 1:00 PM to 6:00 PM ABT Board of Directors Meeting Marriott Hotel & Marina Del Mar Room 2:00 PM to 5:00 PM Committee Chair Orientation San Diego Convention Center Room 14B 4:00 PM to 7:00 PM Message Center/Housing Desk San Diego Convention Center Hall B Lobby 4:00 PM to 7:00 PM Registration San Diego Convention Center Hall A Lobby 9:00 AM to 5:00 PM 5:00 to AM 9:00 Description (See page 57 in the Program for Registration Information.) Marriott Hotel & Marina & Hotel Marriott
ADME
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Sunday Saturday Friday Manchester Room CRAD Committee Meeting I Marriott Hotel & Marina Oceanside Room 8:00 AM to 4:30 PM Guest Hospitality Center Marriott Hotel & Marina 7:30 AM to 2:30 PM Concession Stands San Diego Convention Center Hall A Lobby and Ballroom 6 Lobby 8:00 AM to 10:00 AM Room 14A 7:00 AM to 5:00 PM San Diego Convention Center Hall A Lobby San Diego Convention Center Room 14A 7:00 AM to 5:30 PM Speaker Ready Room San Diego Convention Center 7:00 AM to 8:00 PM Registration San Diego Convention Center Hall A Lobby 7:00 AM to 5:30 PM SOT Office 7:00 AM to 5:00 PM Message Center/Housing Desk San Diego Convention Center Hall B Lobby San Diego Convention Center (See Signage for Room Location) 7:00 AM to 8:30 PM Luggage Check San Diego Convention Center Hall B2 Lobby Events are listed alphabetically by the event start time. 7:00 AM to 7:45 AM Continuing Education Sunrise Required) Mini-Course (Ticket Tour Desk Tour (Hours are Subject to Change) (Hours are See page 57 in the Program Description See page 57 in the Program for Registration Information. 11:30 AM to 6:00 PM Interest Group Marriott Hotel & Marina Cardiff Room Marriott Hotel & Marina Columbia Room 8:00 AM to 1:30 PM 1:30 to AM 8:00 Council Meeting Marriott Hotel & Marina Manchester Room 9:00 AM to 5:00 PM Events are listed alphabetically by the event start time. Events are listed alphabetically by the event start time. Bioaccumulation Workshop HESI/SETAC In Vitro HESI/SETAC
Johnson & Johnson Toxicology Calendar by &Time Calendar Day
EVENT CALENDAR 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Day &Time (Continued) Monday March 6, 2006
Events are listed alphabetically by 7:00 AM to 5:00 PM 9:30 AM to 12:00 NOON 4:30 PM to 6:00 PM the event start time. Speaker Ready Room Scientific Sessions Specialty Section Presidents Meeting San Diego Convention Center San Diego Convention Center San Diego Convention Center 6:15 AM to 7:30 AM Room 14A (See Program Description for Room Room 14B Locations) Comparative and Veterinary 7:00 AM to 5:00 PM 4:30 PM to 6:00 PM Specialty Section Officers Breakfast Tour Desk 9:30 AM to 4:30 PM Special Session—Using Animals San Diego Convention Center San Diego Convention Center ToxExpoTM Exhibits Open for Toxicological Research and Room 4 Hall A Lobby San Diego Convention Center Testing: Best Practices for Assuring 6:30 AM to 8:00 AM (Hours are Subject to Change) Exhibit Hall Compliance with Animal Welfare Regulations, Policies, and Guidelines Regulatory Affairs and Legislative 7:30 AM to 2:30 PM 11:30 AM to 1:00 PM Assistance Committee Meeting San Diego Convention Center Concession Stands Post-Doctoral Assembly Board Room 1A San Diego Convention Center San Diego Convention Center Meeting Room 19 Hall A Lobby and Room 6 Lobby San Diego Convention Center 5:00 PM to 7:00 PM 6:30 AM to 8:00 AM Room 12 Gulf Coast and South Central 7:30 AM to 8:30 AM Regional Chapters Joint Reception Toxicological and Exploratory Membership Committee Meeting 12:00 NOON to 1:30 PM Pathology Specialty Section Officer th Marriott Hotel & Marina San Diego Convention Center 45 Anniversary Raffle Contest Torrance Room Meeting Room 10 San Diego Convention Center
San Diego Convention Center Exhibit Hall 5:00 PM to 6:00 PM EVENT CALENDAR Room 17A 7:30 AM to 8:30 AM Special Interest Group—American Program Committee Walk-Through 12:00 NOON to 1:30 PM 7:00 AM to 8:00 AM Association of Chinese in Toxicology San Diego Convention Center Comparative and Veterinary Distinguished Chinese Toxicologist American Board of Veterinary Room 5 Specialty Section Meeting/Reception Toxicology—Business Meeting Lecture San Diego Convention Center Marriott Hotel & Marina Marriott Hotel & Marina 8:00 AM to 4:00 PM Room 4 Newport Beach Room CRAD Job Bank Center San Diego Ballroom A Marriott Hotel & Marina 12:00 NOON to 1:30 PM 7:00 AM to 8:30 AM 5:00 PM to 7:00 PM Leucadia Room Occupational and Public Health Taylor and Francis Reception Continuing Education Committee Specialty Section Meeting/Reception Meeting 8:00 AM to 4:30 PM Marriott Hotel & Marina San Diego Convention Center Marina Ballroom F San Diego Convention Center Guest Hospitality Center Room 3 Room 14B Marriott Hotel & Marina 5:30 PM to 8:00 PM Manchester Room 1:00 PM to 2:00 PM 7:00 AM to 8:30 AM Special Interest Group—Korean IUTOX Communications Toxicologists Association in America Immunotoxicology Specialty Section 8:00 AM to 2:00 PM Commission Meeting Program Committee Meeting Undergraduate Education Program Meeting/Reception Marriott Hotel & Marina Marriott Hotel & Marina Marriott Hotel & Marina San Diego Convention Center Encinitas Room Oceanside Room Room 16B Columbia Rooms 1 & 2 1:30 PM to 4:30 PM 6:00 PM to 7:30 PM 7:00 AM to 8:30 PM 8:30 AM to 9:15 AM Poster Sessions Luggage Check Plenary Lecture—Risk Carcinogenesis Specialty Section San Diego Convention Center Meeting/Reception San Diego Convention Center Communication—The Perception Exhibit Hall Hall B2 Lobby Gap, an Unrecognized Aspect of Risk San Diego Convention Center David Ropeik 1:30 PM to 4:30 PM Room 10 7:00 AM to 8:30 AM San Diego Convention Center Scientific Sessions 6:00 PM to 7:30 PM Mechanisms Specialty Section Room 6 San Diego Convention Center Officer Meeting Drug Discovery Specialty Section (See Program Description for Room Meeting/Reception San Diego Convention Center 9:00 AM to 9:30 AM Locations) Room 9 Poster Set Up San Diego Convention Center San Diego Convention Center 1:30 PM to 2:30 PM Room 3 7:00 AM to 5:00 PM TM Exhibit Hall VIP ToxExpo Exhibit Hall 6:00 PM to 7:30 PM Message Center/Housing Desk Walk-Through San Diego Convention Center 9:30 AM to 10:30 AM Immunotoxicology Specialty Section San Diego Convention Center Meeting/Reception Hall B Lobby Complimentary Coffee Exhibit Hall (See signage in Exhibit Hall) San Diego Convention Center 7:00 AM to 8:30 AM th San Diego Convention Center 4:30 PM to 6:00 PM Room 4 Past Presidents 45 Anniversary Exhibit Hall ABT Open Mixer Meeting Breakfast 6:00 PM to 8:00 PM Marriott Hotel & Marina ITR Hospitality Reception San Diego Convention Center 9:30 AM to 2:30 PM Rancho Las Palmas Room Room 12 Concession Stands Marriott Hotel & Marina (See Exhibit Hall map on page 23) 4:30 PM to 6:00 PM Cardiff Room 7:00 AM to 5:00 PM San Diego Convention Center CRAD Seminar—Life After Your Registration 6:00 PM to 7:30 PM Exhibit Hall Post-Doc: Advice on Finding Mechanisms Specialty Section San Diego Convention Center and Landing a Job Hall A Lobby 9:30 AM to 4:30 PM Meeting/Reception San Diego Convention Center San Diego Convention Center Internet Cafe Room 2 7:00 AM to 8:00 AM (See Exhibit Hall Map on page 23) Room 9 Regulatory and Safety Evaluation San Diego Convention Center 4:30 PM to 6:00 PM Specialty Section Officer Meeting 6:00 PM to 7:30 PM Exhibit Hall Environmental Health Perspectives Mixtures Specialty Section San Diego Convention Center Editorial Board Meeting Room 11A 9:30 AM to 1:00 PM Organizational Meeting/Reception Marriott Hotel & Marina (All Invited to Plan Formation of IUTOX Executive Committee Green Room 7:00 AM to 9:00 AM Meeting II Section) Reproductive and Developmental Marriott Hotel & Marina 4:30 PM to 6:00 PM San Diego Convention Center Specialty Section Officer Meeting Del Mar Room Roundtable and Sunset Room 15B San Diego Convention Center Scientific Sessions 6:00 PM to 8:00 PM Room 15B 9:30 AM to 11:15 AM San Diego Convention Center Poster Session for Visiting Students Northern California and Pacific 7:00 AM to 9:00 AM (See Program Description for Room Northwest Regional Chapters and San Diego Convention Center Locations) Risk Assessment Specialty Section Exhibit Hall UC Davis Joint Meeting/Reception Officer Meeting 4:30 PM to 7:00 PM Marriott Hotel & Marina San Diego Convention Center 9:30 AM to 12:00 NOON Roundtable of Toxicology San Diego Ballroom C Room 3 Poster Sessions Consultants Annual Meeting San Diego Convention Center Marriott Hotel & Marina 7:00 AM to 5:00 PM Exhibit Hall SOT Office Marina Ballroom G San Diego Convention Center Room 14A Continued on next page up-to-date information at www.toxicology.org 3
Toxicology Toxicology
Dinner
In Vitro Vitro In
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Systems for the Assessment Anniversary Raffle Contest th March 6, 2006 March 7, 2006 March SOT's 45 SOT's Informational Sessions—High- Informational for Assays Content Room 11A 12:15 PM to 1:15 PM Informational Session— Solutions Using Toxicogenomics BeadArray Technology Illumina’s presented by Illumina San Diego Convention Center Room 11B Continued on next page Appropriate? presented by Data Sciences International (By Invitation Only) Marriott Hotel & Marina Marina Ballroom F 11:45 AM to 1:30 PM Group Luncheon San Diego Convention Center Room 16B 12:00 NOON to 1:30 PM 45 San Diego Convention Center Exhibit Hall 12:00 NOON to 1:00 PM Marriott Hotel & Marina Marina Ballroom D 12:00 NOON to 1:30 PM Issues Session—Safety Assessment of the Major Human Metabolites San Diego Convention Center Room 6F 12:00 NOON to 1:15 PM Toxicology Student In Vitro Lecture and Luncheon San Diego Convention Center Room 33 12:00 NOON to 1:30 PM Special Interest Group—Hispanic Organization for Toxicologists Meeting/Reception Marriott Hotel & Marina Cardiff Room 12:15 PM to 1:15 PM San Diego Convention Center 11:30 AM to 1:00 PM Education Committee Meeting San Diego Convention Center Room 12 11:30 AM to 1:00 PM In Vitro Telemetry in Toxicology: When is it in Toxicology: Telemetry WWW Advisory Committee Focus Required) (Ticket of Toxicology presented by Cellnomics, Inc. Cellnomics, by presented 7:30 PM to 10:00 PM (By Invitation Only) Candelas Restaurant 9:00 PM to 11:00 PM Michigan State University Toxicology Environmental Marriott Hotel & Marina Carlsbad Room Toxicological Sciences Toxicological Reception
(Continued) NOON
Exhibits Open TM
Annual Annual th :30 AM to 4:30 PM :30 AM to 4:30 PM :15 PM to 8:30 PM San Diego Convention Center Convention Diego San (See Program Description for Room (See Program 11:00 AM to 12:00 NOON Informational Session—A Solution Analysis & Data for Toxicogenomics Management presented by Rosetta Resolver® System San Diego Convention Center Room 11B 11:00 AM to 12:00 NOON Session— Informational Pharmacological Your Understanding Normal Across Distribution Target Animal and Human Diseased and Logic Gene by presented Tissues Room 11A 8 San Diego Convention Center Exhibit Hall 9:00 AM to 12:00 Poster Sessions San Diego Convention Center Exhibit Hall 9:00 AM to 12:00 NOON Scientific Sessions San Diego Convention Center Locations) 9:30 AM to 10:30 AM (See signage in Exhibit Hall) San Diego Convention Center Exhibit Hall 9:30 AM to 2:30 PM Concession Stands (See Exhibit Hall Map on page 23) San Diego Convention Center Exhibit Hall 9:45 AM to 10:45 AM San Diego Convention Center Room 11B 9:45 AM to 10:45 AM Informational Session—The Fundamentals of Toxicogenomics presented by Gene Logic San Diego Convention Center Room 11A 10:00 AM to 11:30 AM San Diego Convention Center Room 19 8 Internet Cafe (See Exhibit Hall Map on page 23) San Diego Convention Center Exhibit Hall Complimentary Coffee by CROs presented by SFBC SFBC by presented CROs by International ToxLearn Work Group Work ToxLearn ToxExpo Informational Session—Contracting Session—Contracting Informational the and Studies Tox for Bioanalysis Process Costing the of Evolution 6:30 PM to 8:30 PM Social Marriott Hotel & Marina Balboa Room 7 Specialty Section: Great Debate— What is Human and Animal Testing: Appropriate? Room 11A Neurobehavioral Teratology Society Neurobehavioral Teratology Regulatory Evaluation and Safety San Diego Convention Center Convention Diego San 45 4
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Specialty Section Officer :00 AM to 4:00 PM Toxicology Alumni Dinner Toxicology 6:00 PM to 8:00 PM Special Interest Group—Association in of Scientists of Indian Origin America Meeting/Reception Marriott Hotel & Marina Marina Ballroom E 6:00 PM to 8:00 PM St. Johns University 4 Marriott Hotel & Marina Newport Beach Room (See Program Description for Room (See Program Animals in Research Committee Animals in Research In Vitro Specialty Dermal Toxicology Council Medical Research San Diego Convention Center Room 11A San Diego Convention Center Room 6A 8:00 AM to 4:00 PM Message Center/Housing Desk San Diego Convention Center Hall A Lobby 8:00 AM to 4:00 PM Registration San Diego Convention Center Hall A Lobby 8 San Diego Convention Center Hall A Lobby 8:30 AM to 9:30 AM Informational Session— Bioluminescent Methods for presented by Promega ADME/Tox Corporation Sunrise Scientific Session San Diego Convention Center Location) 8:00 AM to 4:00 PM CRAD Job Bank Center Marriott Hotel & Marina Leucadia Room 8:00 AM to 9:30 AM Section Officers Meeting San Diego Convention Center Room 3 8:00 AM to 4:30 PM Guest Hospitality Center Marriott Hotel & Marina Manchester Room 8:00 AM to 8:50 AM (MRC) Lecture—Cell Death and Neurodegeneration 7:15 AM to 8:30 AM Meeting San Diego Convention Center Room 19 7:30 AM to 9:30 AM Items Concession Stands (Breakfast San Diego Convention Center Hall A Lobby and Ballroom 6 Lobby 7:30 AM to 8:30 AM Meeting San Diego Convention Center Room 16A 7:30 AM to 8:50 AM Dr. Junying Yuan Dr. Tour Desk Tour (Hours are Subject to Change) (Hours are
45th Annual Meeting and ToxExpo and Meeting Annual 45th
(By Invitation Only)
Monday (Continued) Monday (Continued) Tuesday Regulatory Evaluation and Safety Marriott Hotel & Marina San Diego Ballroom A San Diego Convention Center Room 11A 6:00 PM to 8:00 PM Special Interest Group—American Association of Chinese in Meeting/Reception Toxicology 6:00 PM to 7:30 PM Specialty Section Meeting/Reception Torrance Room Torrance Women in Toxicology Specialty in Toxicology Women Student Advisory Committee Gene Logic Toxicology Consultant Gene Logic Toxicology Workshop Academy of Toxicological Sciences Academy of Toxicological 7:00 AM to 8:00 AM Section Officers Meeting San Diego Convention Center Room 10 7:00 AM to 8:30 AM Meeting II San Diego Convention Center Room 12 Room 14A 7:00 AM to 4:00 PM Speaker Ready Room San Diego Convention Center Room 14A San Diego Convention Center Room 14B 7:00 AM to 4:00 PM SOT Office San Diego Convention Center Officers Meeting San Diego Convention Center Room 9 7:00 AM to 8:30 AM Regional Chapter Presidents Meeting Officer Meeting San Diego Convention Center Room 17A 7:00 AM to 9:00 AM Neurotoxicology Specialty Section 7:00 AM to 8:00 PM Luggage Check San Diego Convention Center Hall B2 Lobby 7:00 AM to 8:00 AM Molecular Biology Specialty Section 7:00 AM to 8:00 AM Marriott Hotel & Marina 7:00 AM to 8:30 AM Food Safety Specialty Section Officers Meeting San Diego Convention Center Room 4 7:00 AM to 8:30 AM Board Meeting Marriott Hotel & Marina Carlsbad Room 6:50 AM to 8:00 AM University of Louisiana at Monroe TOX Breakfast Marriott Hotel & Marina Cardiff Room Events are listed alphabetically by the event start time. Calendar by &Time Calendar Day
EVENT CALENDAR 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Day &Time (Continued) Tuesday (Continued) March 7, 2006
1:30 PM to 2:30 PM 2:45 PM to 3:45 PM 6:00 PM to 9:00 PM 6:00 PM to 8:30 PM Informational Session—GeneChip® Informational Session—Applications GLKK Toxicogenomics Seminar Special Interest Group—African Microarrays and Their Use In of GeneChip® Technology for (By Invitation Only) Society of Toxicological Sciences Toxicogenomics: Part One presented Toxicogenomics: Part Two presented Marriott Hotel & Marina Symposium/Meeting/Reception by Affymetrix by Affymetrix Rancho Las Palmas Room Marriott Hotel & Marina San Diego Convention Center San Diego Convention Center Marina Ballroom D Room 11A Room 11A 6:00 PM to 7:30 PM In Vitro Specialty Section Meeting/ 6:00 PM to 7:30 PM 1:30 PM to 2:30 PM 2:45 PM to 3:45 PM Reception Toxicologic and Exploratory Informational Session—New and Novel Informational Session—Expert San Diego Convention Center Pathology Specialty Section Biomarkers in Nephrotoxicity Testing Services and Custom Solutions Room 9 Meeting/Reception presented by Biotrin International presented by Dow Corning San Diego Convention Center San Diego Convention Center San Diego Convention Center 6:00 PM to 7:30 PM Room 16A Room 11B Room 11B Metals Specialty Section Meeting/ Reception 6:00 PM to 7:30 PM 1:30 PM to 4:30 PM 4:30 PM to 6:00 PM San Diego Convention Center Women in Toxicology Specialty Poster Sessions SOT Annual Business Meeting Room 3 Section Meeting/Reception San Diego Convention Center 45th Anniversary San Diego Convention Center Exhibit Hall (SOT Members Only) 6:00 PM to 7:30 PM Room 10 Molecular Biology Specialty Section
San Diego Convention Center EVENT CALENDAR 1:30 PM to 4:30 PM Room 5B Meeting/Reception 6:30 PM to 7:30 PM Scientific Sessions San Diego Convention Center International Neurotoxicology San Diego Convention Center 4:45 PM to 6:00 PM Room 17A Association Business Meeting (See Program Description for Room ToxExpoTM 2007 Exhibit Space Marriott Hotel & Marina Locations) Selection Meeting 6:00 PM to 8:00 PM Green Room San Diego Convention Center Northeast Regional Chapter 2:00 PM to 3:30 PM Room 11A Reception 7:30 PM to 10:00 PM Meeting with Dr. Kenneth Olden for Marriott Hotel & Marina University of Rochester Toxicology Students/Post-Doctoral Fellows to 5:00 PM to 7:00 PM Cardiff Room Alumni Reception Discuss NIEHS Research Opportunities Southern California and Mountain Marriott Hotel & Marina (All Students Invited) West Joint Reception 6:00 PM to 7:30 PM Manchester Room San Diego Convention Center Rama Restaurant Reproductive and Developmental Room 16A Specialty Section Meeting/Reception 9:00 PM to 11:00 PM 6:00 PM to 7:30 PM San Diego Convention Center Rutgers University Joint Graduate Food Safety Specialty Section Room 15B Program in Toxicology Annual Meeting/Reception Dessert Reception San Diego Convention Center Marriott Hotel & Marina Room 4 Marina Ballroom E Wednesday March 8, 2006
Events are listed alphabetically by 7:30 AM to 9:30 AM 8:30 AM to 9:30 AM 9:30 AM to 2:30 PM the event start time. Concession Stands (Breakfast Items) Informational Session—Cardiac Concession Stands San Diego Convention Center Safety—Current Thinking When (See Exhibit Hall Map on page 23) 7:00 AM to 8:30 AM Hall A Lobby Approaching Safety Assessment San Diego Convention Center Studies presented by Covance Exhibit Hall Committee on Diversity Initiatives 7:30 AM to 8:30 AM Meeting San Diego Convention Center Special Interest Group Task Force Room 11B 9:45 AM to 10:45 AM San Diego Convention Center Meeting Informational Session—Create Room 19 San Diego Convention Center 8:30 AM to 9:30 AM Bibliographies Instantly with 7:00 AM to 8:00 PM Room 9 Informational Session—Morpholino EndNote and Discover New Luggage Check Antisense Oligos for Blocking Reference Tools presented by 8:00 AM to 4:00 PM Translation and Modifying Splicing Thomson ResearchSoft San Diego Convention Center CRAD Job Bank Center Hall B2 Lobby presented by Gene Tools San Diego Convention Center San Diego Convention Center San Diego Convention Center Room 11A 7:00 AM to 8:30 AM Leucadia Room Room 11A 9:45 AM to 10:45 AM Midwest Regional Chapter Members 8:00 AM to 4:30 PM Breakfast Meeting 8:30 AM to 4:30 PM Informational Session—Expanding Guest Hospitality Center Internet Cafe Role of Telemetry in Toxicology Marriott Hotel & Marina Marriott Hotel & Marina Rancho Las Palmas Room (See Exhibit Hall Map on page 23) presented by Data Sciences Manchester Room San Diego Convention Center International 7:00 AM to 4:00 PM 8:00 AM to 4:00 PM Exhibit Hall San Diego Convention Center SOT Office Room 11B Message Center/Housing Desk 8:30 AM to 4:30 PM San Diego Convention Center San Diego Convention Center Room 14A ToxExpoTM Exhibits Open 11:00 AM to 12:00 NOON Hall B Lobby San Diego Convention Center Informational Session—Integration 7:00 AM to 4:00 PM 8:00 AM to 4:00 PM Exhibit Hall of In-Life Parameters with Speaker Ready Room Registration Toxicogenomics presented by San Diego Convention Center 9:00 AM to 10:30 AM Gene Logic, Inc. San Diego Convention Center Complimentary Coffee Room 14A Hall A Lobby San Diego Convention Center (See signage in Exhibit Hall) Room 11A 7:00 AM to 8:30 AM 8:00 AM to 8:50 AM San Diego Convention Center Technical Committee Meeting of the SOT/EUROTOX Debate: ‘Omics’ Exhibit Hall 11:00 AM to 12:00 NOON Inhalation Specialty Section Informational Session—The Future Research Does Not Add Substantially 9:00 AM to 12:00 NOON San Diego Convention Center to the Safety Assessment of Chemicals of Hematopoietic Testing presented Room 3 Poster Sessions by StemCell Technologies, Inc. San Diego Convention Center San Diego Convention Center 7:00 AM to 8:30 AM Room 6A San Diego Convention Center Exhibit Hall Room 11B WWW Advisory Committee Meeting 8:00 AM to 4:00 PM San Diego Convention Center 9:00 AM to 12:00 NOON 11:30 AM to 1:30 PM Tour Desk Scientific Sessions Room 12 San Diego Convention Center Committee for K–12 Education San Diego Convention Center Meeting Hall A Lobby (See Program Descriptions for Room (Hours are Subject to Change) San Diego Convention Center Locations) Room 12 Continued on next page up-to-date information at www.toxicology.org 5
Annual Meeting Annual th March 8, 2006 March March 9, 2006 March SOT's 45 SOT's 6:00 PM to 7:30 PM Risk Assessment Specialty Section Meeting/Reception San Diego Convention Center Room 16A 7:00 PM to 8:30 PM (By Invitation Only) Marriott Hotel & Marina Bayside Room 6:00 PM to 7:30 PM Biological Modeling Specialty Section Meeting/Reception San Diego Convention Center Room 10 6:00 PM to 7:30 PM Section Meeting/Reception San Diego Convention Center Room 4 6:00 PM to 7:30 PM Inhalation Specialty Section Meeting/Reception San Diego Convention Center Room 3 6:00 PM to 7:30 PM Neurotoxicology Specialty Section Meeting/Reception San Diego Convention Center Room 9 President’s Reception President’s Dermal Toxicology Specialty Dermal Toxicology
(Continued)
Annual Annual th :30 PM to 5:20 PM (See Program Description for Room (See Program San Diego Convention Center Room 15B 5:15 PM to 6:00 PM Council Meeting with Executive Board of Student Advisory Committee and Post-Doctoral Assembly San Diego Convention Center Room 12 6:00 PM to 9:00 PM Dinner Marriott Hotel & Marina Columbia Room 4:30 PM to 6:00 PM Sessions Roundtable and Scientific San Diego Convention Center Locations) 4 Lecture San Diego Convention Center Room 15A 4:30 PM to 6:00 PM Meeting: Recent Changes in Participation Requirements on Government Advisory Groups/ Panels San Diego Convention Center Room 6F 4:45 PM to 5:15 PM Doctoral Fellows Academy of Toxicological Sciences Academy of Toxicological Special Session—Merit Awardee Special Session—Merit Awardee Hall Special Session—Town Students/Post- with Meeting Council 45 6
In In Meeting & ToxExpo & Meeting
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Sciences :00 AM to 11:30 AM :00 AM to 12:00 (See Program Description for Room (See Program Room 6E San Diego Convention Center Hall A Lobby 8 San Diego Convention Center Hall A Lobby 9 Poster Sessions San Diego Convention Center Room 6 9:00 AM to 12:00 NOON Scientific Sessions San Diego Convention Center Locations) 9:00 AM to 12:00 NOON Special Session—Hurricane Katrina: Interface Between Response and Research San Diego Convention Center 8:00 AM to 8:50 AM Historical Highlight Session— Organophosphates from Nerve to Gas to Insecticide San Diego Convention Center Room 7B 8:00 AM to 11:30 AM Message Center/Housing Desk San Diego Convention Center Hall B Lobby 8:00 AM to 11:30 AM Registration Tour Desk Tour (Hours are Subject to Change) (Hours are (See Program Description for Room (See Program Grantsmanship Forum: Sources for Grantsmanship Forum: Sources Vitro Informational Session—Using Session—Using Informational Enhance to Evaluation Histological and Opacity Cornea Bovine the Ocular for Assay (BCOP) Permeability for Institute by presented Irritation Room 6E San Diego Convention Center Exhibit Hall 1:30 PM to 4:30 PM Scientific Sessions San Diego Convention Center Locations) 2:00 PM to 4:00 PM Exhibit Liaison Committee Meeting San Diego Convention Center Room 12 2:30 PM to 4:30 PM Board of Publications Committee Meeting San Diego Convention Center Room 19 4:30 PM to 6:00 PM Funding Support San Diego Convention Center 1:30 PM to 2:30 PM San Diego Convention Center Room 11A 1:30 PM to 4:30 PM Poster Sessions
45th Annual Meeting and ToxExpo and Meeting Annual 45th
ADME/Tox Technologies Technologies ADME/Tox
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Anniversary Raffle Contest th :00 AM to 12:00 NOON Wednesday (Continued) (Continued) Wednesday Thursday Manchester Room Marriott Hotel & Marina Solana Room 8:00 AM to 11:30 AM Guest Hospitality Center Marriott Hotel & Marina San Diego Convention Center Room 19 8 CRAD Job Bank Center (Message Center Only) 7:30 AM to 9:30 AM CRAD Committee Meeting II Marriott Hotel & Marina Oceanside Room 7:30 AM to 8:30 AM Program Committee Meeting 7:30 AM to 12:00 NOON Concession Stands San Diego Convention Center Hall A Lobby Room 14A 7:00 AM to 11:30 AM Speaker Ready Room San Diego Convention Center Room 14A Luggage Check San Diego Convention Center Hall B2 Lobby 7:00 AM to 11:30 AM SOT Office San Diego Convention Center Events are listed alphabetically by the event start time. 7:00 AM to 1:00 PM for Metabolism and Toxicity for Metabolism and Toxicity presented by BD Biosciences San Diego Convention Center Room 11B San Diego Convention Center Room 11A 1:30 PM to 2:30 PM Informational Session—Novel BD Gentest Room 6D 12:15 PM to 1:15 PM Informational Session—Advances in Integrated Microarray Analysis presented by Agilent 12:00 NOON to 1:30 PM Directors: Special Session—Meet the Update of Activities at Government Agencies San Diego Convention Center Room 19 12:00 NOON to 1:30 PM 45 San Diego Convention Center Exhibit Hall 11:30 AM to 1:30 PM Finance Committee Meeting San Diego Convention Center Calendar by Day &Time by &Time Calendar Day
EVENT CALENDAR 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Event Name Refer to the Scientific Index on page 43 for Scientific Session details. EVENT: DATE: TIME: LOCATION: ROOM:
25-Year (or More) Member Reception Sun, March 5 7:00 PM to 8:00 PM San Diego Convention Center Room 4 Celebrating 45th Anniversary (By Invitation Only) 45th Anniversary Raffle Contest Mon, March 6 12:00 NOON to 1:30 PM San Diego Convention Center Exhibit Hall 45th Anniversary Raffle Contest Tue, March 7 12:00 NOON to 1:30 PM San Diego Convention Center Exhibit Hall 45th Anniversary Raffle Contest Wed, March 8 12:00 NOON to 1:30 PM San Diego Convention Center Exhibit Hall A Solution for Data Toxicogenenomics Analysis Tue, March 7 11:00 AM to 12:00 NOON San Diego Convention Center Room 11B & Management presented by Rosetta Resolver System (Informational Session) ABT Board of Directors Meeting Sat, March 4 1:00 PM to 6:00 PM Marriott Hotel & Marina Del Mar Room ABT Open Mixer Meeting Mon, March 6 4:30 PM to 6:00 PM Marriott Hotel & Marina Rancho Las Palmas Room Academic Program Session for Undergraduate Sun, March 5 3:00 PM to 5:00 PM San Diego Convention Center Room 17B Students Academy of Toxicological Sciences Board Tue, March 7 7:00 AM to 8:30 AM Marriott Hotel & Marina Carlsbad Room
Meeting EVENT CALENDAR Academy of Toxicological Sciences Dinner Wed, March 8 6:00 PM to 9:00 PM Marriott Hotel & Marina Columbia Room Advances in Integrated Wed, March 8 12:15 PM to 1:15 PM San Diego Convention Center Room 11A Microarray Analysis presented by Agilent (Informational Session) African Society of Toxicological Tue, March 7 6:00 PM to 8:30 PM Marriott Hotel & Marina Marina Sciences Symposium Meeting/Reception Ballroom D (Special Interest Group) American Association of Chinese in Toxicology: Mon, March 6 5:00 PM to 6:00 PM Marriott Hotel & Marina San Diego Distinguished Chinese Toxicologist Lecture Ballroom A American Association of Chinese in Toxicology Mon, March 6 6:00 PM to 8:00 PM Marriott Hotel & Marina San Diego Meeting/Reception (Special Interest Group) Ballroom A American Board of Veterinary Toxicology Mon, March 6 7:00 AM to 8:00 AM Marriott Hotel & Marina Newport Beach Business Meeting Room Animals in Research Committee Meeting Tue, March 7 7:15 AM to 8:30 AM San Diego Convention Center Room 19 Annual Business Meeting (SOT Members Only) Tue, March 7 4:30 PM to 6:00 PM San Diego Convention Center Room 5B Applications of GeneChip Technology for Tue, March 7 2:45 PM to 3:45 PM San Diego Convention Center Room 11A Toxicogenomics: Part Two presented by Affymetrix (Informational Session) Arizona Night Sun, March 5 8:00 PM to 10:30 PM Marriott Hotel & Marina San Diego Ballroom A Association of Scientists of Indian Origin in Mon, March 6 6:00 PM to 8:00 PM Marriott Hotel & Marina Marina Ballroom E America Meeting/Reception ( Special Interest Group) Awards Ceremony Celebrating 45th Anniversary Sun, March 5 5:15 PM to 6:30 PM San Diego Convention Center Room 6C Awards Recipients Photographed Sun, March 5 4:00 PM to 5:15 PM San Diego Convention Center Room 3 Biological Modeling Specialty Section Wed, March 8 6:00 PM to 7:30 PM San Diego Convention Center Room 10 Meeting/Reception Bioluminescent Methods for ADME/Tox presented Tue, March 7 8:30 AM to 9:30 AM San Diego Convention Center Room 11A by Promega Corporation (Informational Session) Board of Publications Committee Meeting Wed, March 8 2:30 PM to 4:30 PM San Diego Convention Center Room 19 Carcinogenesis Specialty Section Meeting/Reception Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 10 Cardiac Safety—Current Thinking When Wed, March 8 8:30 AM to 9:30 AM San Diego Convention Center Room 11B Approaching Safety Assessment Studies presented by Covance (Informational Session) Career Resource & Development Committee Sun, March 5 8:00 AM to 10:00 AM Marriott Hotel & Marina Oceanside Room Meeting I Career Resource and Development Committee Thu, March 9 7:30 AM to 9:30 AM Marriott Hotel & Marina Oceanside Room Meeting II Career Resource and Development Seminar— Mon, March 6 4:30 PM to 6:00 PM San Diego Convention Center Room 2 Life After Your Post-Doc: Advice on Finding and Landing a Job Continuing Education Luncheon for Speakers, Sun, March 5 11:45 AM to 1:15 PM San Diego Convention Center Room 4 Committee, and Students (By Invitation Only) Committee Chair Orientation Sat, March 4 2:00 PM to 5:00 PM San Diego Convention Center Room 14B Committee for K–12 Education Meeting Wed, March 8 11:30 AM to 1:30 PM San Diego Convention Center Room 12 Committee on Diversity Initiatives Meeting Wed, March 8 7:00 AM to 8:30 AM San Diego Convention Center Room 19 Comparative and Veterinary Specialty Section Mon, March 6 12:00 NOON to 1:30 PM San Diego Convention Center Room 4 Meeting/Reception up-to-date information at www.toxicology.org 7 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Event Name (Continued) Refer to the Scientific Index on page 43 for Scientific Session details. EVENT: DATE: TIME: LOCATION: ROOM: Comparative and Veterinary Specialty Section Mon, March 6 6:15 AM to 7:30 AM San Diego Convention Center Room 4 Officers Breakfast Continuing Education Committee Meeting Mon, March 6 7:00 AM to 8:30 AM San Diego Convention Center Room 14B
EVENT CALENDAR EVENT Continuing Education Courses AM Sun, March 5 1:15 PM to 5:00 PM San Diego Convention Center See Signage for Room (Ticket Required) Locations Continuing Education Courses PM Sun, March 5 8:15 PM to 12:00 NOON San Diego Convention Center See Signage for Room (Ticket Required) Locations Continuing Education Sunrise Mini-Course Sun, March 5 7:00 AM to 7:45 AM San Diego Convention Center See Signage for Room (Ticket Required) Locations Continuing Education Committee Walk-Through Sat, March 4 5:00 PM to 5:45 PM San Diego Convention Center Room 5 Contracting Bioanalysis for Tox Studies and the Tue, March 7 9:45 AM to 10:45 AM San Diego Convention Center Room 11B Evolution of the Costing Process by CRO’s presented by SFBC International (Informational Session) Council Meeting Sat, March 4 8:00 AM to 1:30 PM Marriott Hotel & Marina Manchester Room Council Meeting with Executive Board of Student Wed, March 8 5:15 PM to 6:00 PM San Diego Convention Center Room 12 Advisory Committee and Post-Doctoral Assembly Council Meeting with Students/Post-Doctoral Wed, March 8 4:45 PM to 5:15 PM San Diego Convention Center Room 15B Fellows Create Bibliographies Instantly with EndNote Wed, March 8 9:45 AM to 10:45 AM San Diego Convention Center Room 11A and Discover New Reference Tools presented by Thomson ResearchSoft (Informational Session) Dermal Toxicology Specialty Section Wed, March 8 6:00 PM to 7:30 PM San Diego Convention Center Room 4 Meeting/Reception Dermal Toxicology Specialty Section Tue, March 7 8:00 AM to 9:30 AM San Diego Convention Center Room 3 Officers Meeting Drug Discovery Specialty Section Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 3 Meeting/Reception Education Committee Meeting Tue, March 7 11:30 AM to 1:00 PM San Diego Convention Center Room 12 Education Fellowship Interviews Sat, March 4 5:30 PM to 8:30 PM San Diego Convention Center Room 12 Environmental Health Perspectives Editorial Mon, March 6 4:30 PM to 6:00 PM Marriott Hotel & Marina Green Room Board Meeting EUROTOX/SOT Debate—’Omics’ Research Does Wed, March 8 8:00 AM to 8:50 AM San Diego Convention Center Room 6A Not Add Substantially to the Safety Assessment of Chemicals Exhibit Liaison Committee Meeting Wed, March 8 2:00 PM to 4:00 PM San Diego Convention Center Room 12 Expanding Role of Telemetry in Toxicology Wed, March 8 9:45 AM to 10:45 AM San Diego Convention Center Room 11B presented by Data Sciences International (Informational Session) Expert Services and Custom Solutions presented Tue, March 7 2:45 PM to 3:45 PM San Diego Convention Center Room 11B by Dow Corning (Informational Session) Finance Committee Meeting Wed, March 8 11:30 AM to 1:30 PM San Diego Convention Center Room 19 Food Safety Specialty Section Meeting/Reception Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 4 Food Safety Specialty Section Officers Meeting Tue, March 7 7:00 AM to 8:30 AM San Diego Convention Center Room 4 Fundamentals of Toxicogenomics presented by Tue, March 7 9:45 AM to 10:45 AM San Diego Convention Center Room 11A Gene Logic (Informational Session) Future of Hematopoietic Testing presented Wed, March 8 11:00 AM to 12:00 NOON San Diego Convention Center Room 11B by StemCell Technologies, Inc. (Informational Session) Gene Logic Toxicology Consultant Tue, March 7 7:00 AM to 8:00 AM Marriott Hotel & Marina Torrance Room Workshop (By Invitation Only) GeneChip Microarrays and their Use in Tue, March 7 1:30 PM to 2:30 PM San Diego Convention Center Room 11A Toxicogenomics: Part One presented by Affymetrix GLKK Toxicogenomics Seminar (By Invitation Only) Tue, March 7 6:00 PM to 9:00 PM Marriott Hotel & Marina Rancho Las Palmas Room Grantsmanship Forum—Sources for Funding Wed, March 8 4:30 PM to 6:00 PM San Diego Convention Center Room 6E Support Gulf Coast and South Central Joint Reception Mon, March 6 5:00 PM to 7:00 PM Marriott Hotel & Marina Torrance Room HESI/SETAC In Vitro ADME Bioaccumulation Fri, March 3 9:00 AM to 5:00 PM Marriott Hotel & Marina Columbia Room Workshop (Registration Required) HESI/SETAC In Vitro ADME Bioaccumulation Sat, March 4 9:00 AM to 5:00 PM Marriott Hotel & Marina Columbia Room Workshop (Registration Required) 8 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Event Name (Continued) Refer to the Scientific Index on page 43 for Scientific Session details. EVENT: DATE: TIME: LOCATION: ROOM:
High Content Assays for In Vitro Toxicology Tue, March 7 12:15 PM to 1:15 PM San Diego Convention Center Room 11A presented by Cellnomics, Inc. (Informational Session) Hispanic Organization for Toxicologists Tue, March 7 12:00 NOON to 1:30 PM Marriott Hotel & Marina Cardiff Room Meeting/Reception (Special Interest Group) Hurricane Katrina: Interface Between Response Thu, March 9 9:00 AM to 12:00 NOON San Diego Convention Center Room 6E and Research Special Session Immunotoxicology Specialty Section Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 4 Meeting/Reception Immunotoxicology Specialty Section Program Mon, March 6 7:00 AM to 8:30 AM Marriott Hotel & Marina Oceanside Room Committee Meeting In Vitro Specialty Section Meeting/Reception Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 9 In Vitro Specialty Section Officers Meeting Tue, March 7 7:30 AM to 8:30 AM San Diego Convention Center Room 16A In Vitro Systems for the Assessment of Toxicology Tue, March 7 12:00 NOON to 1:00 PM Marriott Hotel & Marina Marina Ballroom D Inhalation Specialty Section Meeting/Reception Wed, March 8 6:00 PM to 7:30 PM San Diego Convention Center Room 3
Integration of In-Life Parameters with Wed, March 8 11:00 AM to 12:00 NOON San Diego Convention Center Room 11A EVENT CALENDAR Toxicogenomics presented by Gene Logic (Informational Session) International Neurotoxicology Association Tue, March 7 6:30 PM to 7:30 PM Marriott Hotel & Marina Green Room Business Meeting Issues Session—Safety Assessment of the Major Tue, March 7 12:00 NOON to 1:30 PM San Diego Convention Center Room 6F Human Metabolities ITR Hospitality Reception Mon, March 6 6:00 PM to 8:00 PM Marriott Hotel & Marina Cardiff Room IUTOX Communications Commission Meeting Mon, March 6 1:00 PM to 2:00 PM Marriott Hotel & Marina Encinitas Room IUTOX Developing Countries Committee Meeting Sun, March 5 9:30 AM to 11:30 AM Marriott Hotel & Marina Encinitas Room IUTOX Enhancement of the Appreciation and Sun, March 5 8:30 AM to 9:30 AM Marriott Hotel & Marina Encinitas Room Image of Toxicology Task Force Meeting IUTOX Executive Committee Dinner Sun, March 5 8:00 PM to 10:00 PM Top of the Market Restaurant 750 N. Harbor Drive IUTOX Executive Committee Meeting I Sun, March 5 1:00 PM to 5:00 PM Marriott Hotel & Marina Del Mar Room IUTOX Executive Committee Meeting II Mon, March 6 9:30 AM to 1:00 PM Marriott Hotel & Marina Del Mar Room IUTOX Science Commission Meeting Sun, March 5 12:00 NOON to 1:00 PM Marriott Hotel & Marina Encinitas Room Johnson & Johnson Toxicology Interest Group Sat, March 4 11:30 AM to 6:00 PM Marriott Hotel & Marina Cardiff Room K–12 Committee Outreach Event—Paracelus Sun, March 5 10:00 AM to 5:00 PM Natural History Museum Balboa Park Explores the Genome: Toxicology Advances Health (Free Admission for All) Korean Toxicologist Association in America Mon, March 6 5:30 PM to 8:00 PM Marriott Hotel & Marina Columbia Rooms Meeting/Reception (Special Interest Group) 1 & 2 LRRI Annual Reception for Employees Sun, March 5 7:30 PM to 9:30 PM Marriott Hotel & Marina Manchester Room Mechanisms Specialty Section Meeting/Reception Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 9 Mechanisms Specialty Section Officers Meeting Mon, March 6 7:00 AM to 8:30 AM San Diego Convention Center Room 9 Meet the Directors Session: Update of Activities Wed, March 8 12:00 NOON to 1:30 PM San Diego Convention Center Room 6D of Selected Government Agencies Meeting with Dr. Kenneth Olden for Students/ Tue, March 7 2:00 PM to 3:30 PM San Diego Convention Center Room 16A Post-Doctoral Fellows Membership Committee Meeting Mon, March 6 7:30 AM to 8:30 AM San Diego Convention Center Room 10 Merit Awardee Lecture Wed, March 8 4:30 PM to 5:20 PM San Diego Convention Center Room 15A Metals Specialty Section Meeting/Reception Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 3 Michigan State University Environmental Mon, March 6 9:00 PM to 11:00 PM Marriott Hotel & Marina Carlsbad Room Toxicology Reception Midwest Regional Chapter Members Breakfast Wed, March 8 7:00 AM to 8:30 AM Marriott Hotel & Marina Rancho Las Palmas Meeting Room Mixtures Specialty Section Organizational Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 15B Meeting/Reception Molecular Biology Specialty Section Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 17A Meeting/Reception Molecular Biology Specialty Section Officers Meeting Tue, March 7 7:00 AM to 8:00 AM San Diego Convention Center Room 17A Morpholino Antisense Oligos for Blocking Wed, March 8 8:30 AM to 9:30 AM San Diego Convention Center Room 11A Translation and Modifying Splicing presented by Gene Tools (Informational Session) MRC Lecture: Cell Death and Neurodegeneration Tue, March 7 8:00 AM to 8:50 AM San Diego Convention Center Room 6A Neurobehavioral Teratology Society Social Mon, March 6 6:30 PM to 8:30 PM Marriott Hotel & Marina Balboa Room up-to-date information at www.toxicology.org 9 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Event Name (Continued) Refer to the Scientific Index on page 43 for Scientific Session details. EVENT: DATE: TIME: LOCATION: ROOM:
Neurotoxicology Specialty Section Wed, March 8 6:00 PM to 7:30 PM San Diego Convention Center Room 9 Meeting/Reception Neurotoxicology Specialty Section Officers Meeting Tue, March 7 7:00 AM to 9:00 AM San Diego Convention Center Room 9
EVENT CALENDAR EVENT New and Novel Biomarkers in Nephrotoxicity Tue, March 7 1:30 PM to 2:30 PM San Diego Convention Center Room 11B Testing Presented by Biotrin International (Informational Session) Northeast Regional Chapter Reception Tue, March 7 6:00 PM to 8:00 PM Marriott Hotel & Marina Cardiff Room Northern California and Pacific Northwest Regional Mon, March 6 6:00 PM to 8:00 PM Marriott Hotel & Marina San Diego Ballroom C Chapters and UC Davis Joint Reception Novel BD Gentest ADME/Tox Technologies for Wed, March 8 1:30 PM to 2:30 PM San Diego Convention Center Room 11B Metabolism and Toxicity presented by BD Biosciences (Informational Session) Occupational and Public Health Specialty Section Mon, March 6 12:00 NOON to 1:30 PM San Diego Convention Center Room 3 Meeting/Reception Past Presidents 45th Anniversary Breakfast Mon, March 6 7:00 AM to 8:30 AM San Diego Convention Center Room 12 Performance by San Diego Choral Scholars Sun, March 5 4:45 PM to 5:15 PM San Diego Convention Center Room 6C (All Attendees Welcome) Plenary Lecture: Risk Communication— Mon, March 6 8:30 AM to 9:15 AM San Diego Convention Center Room 6 The Perception Gap, an Unrecognized Aspect of Risk Post-Doctoral Assembly Board Meeting Mon, March 6 11:30 AM to 1:00 PM San Diego Convention Center Room 12 Post-Doctoral Assembly Event Sun, March 5 8:00 PM to 9:00 PM San Diego Convention Center Room 32 Poster Session for Visiting Students Mon, March 6 9:30 AM to 11:15 AM San Diego Convention Center Exhibit Hall Poster Sessions Mon, March 6 9:30 AM to 12:00 NOON San Diego Convention Center Exhibit Hall Poster Sessions Mon, March 6 1:30 PM to 4:30 PM San Diego Convention Center Exhibit Hall Poster Sessions Tue, March 7 9:00 AM to 12:00 NOON San Diego Convention Center Exhibit Hall Poster Sessions Tue, March 7 1:30 PM to 4:30 PM San Diego Convention Center Exhibit Hall Poster Sessions Wed, March 8 9:00 AM to 12:00 NOON San Diego Convention Center Exhibit Hall Poster Sessions Wed, March 8 1:30 PM to 4:30 PM San Diego Convention Center Exhibit Hall Poster Sessions Thu, March 9 9:00 AM to 12:00 NOON San Diego Convention Center Room 6 President’s Reception (By Invitation Only) Wed, March 8 7:00 PM to 8:30 PM Marriott Hotel & Marina Bayside Room Program Committee Meeting Thu, March 9 7:30 AM to 8:30 AM San Diego Convention Center Room 19 Program Committee Walk-Through Mon, March 6 7:30 AM to 8:30 AM San Diego Convention Center Room 5 Regional Chapter Presidents Meeting Tue, March 7 7:00 AM to 8:30 AM San Diego Convention Center Room 14B Regulatory Affairs and Legislative Assistance Mon, March 6 6:30 AM to 8:00 AM San Diego Convention Center Room 19 Committee Meeting Regulatory and Safety Evaluation Specialty Mon, March 6 7:15 PM to 8:30 PM San Diego Convention Center Room 11A Section: Great Debate—Human and Animal Testing: What’s Appropriate? Regulatory and Safety Evaluation Specialty Mon, March 6 6:00 PM to 7:30 PM San Diego Convention Center Room 11A Section Meeting/Reception Regulatory and Safety Evaluation Specialty Mon, March 6 7:00 AM to 8:00 AM San Diego Convention Center Room 11A Section Officer Meeting Reproductive and Developmental Specialty Mon, March 6 7:00 AM to 9:00 AM San Diego Convention Center Room 15B Section Officer Meeting Reproductive and Developmental Specialty Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 15B Section Meeting/Reception Risk Assessment Specialty Section Wed, March 8 6:00 PM to 7:30 PM San Diego Convention Center Room 16A Meeting/Reception Risk Assessment Specialty Section Officers Meeting Mon, March 6 7:00 AM to 9:00 AM San Diego Convention Center Room 3 Roundtable of Toxicology Consultants Mon, March 6 4:30 PM to 7:00 PM Marriott Hotel & Marina Marina Ballroom G Annual Meeting Rutgers University Joint Graduate Program in Tue, March 7 9:00 PM to 11:00 PM Marriott Hotel & Marina Marina Ballroom E Toxicology Annual Dessert Reception San Diego University Choral Scholars Performance Sun, March 5 4:45 PM to 5:15 PM San Diego Convention Center Room 6C SOT/EUROTOX Debate—’Omics’ Research Does Wed, March 8 8:00 AM to 8:50 AM San Diego Convention Center Room 6A Not Add Substantially to the Safety Assessment of Chemicals Southern California and Mountain West Joint Tue, March 7 5:00 PM to 7:00 PM Marriott Hotel & Marina Columbia Room Reception Special Interest Group Task Force Meeting Wed, March 8 7:30 AM to 8:30 AM San Diego Convention Center Room 9 10 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Calendar by Event Name (Continued) Refer to the Scientific Index on page 43 for Scientific Session details. EVENT: DATE: TIME: LOCATION: ROOM:
Specialty Section Presidents Meeting Mon, March 6 4:30 PM to 6:00 PM San Diego Convention Center Room 14B St. Johns University 4th Annual Toxicology Mon, March 6 6:00 PM to 8:00 PM Marriott Hotel & Marina Newport Beach Room Alumni Dinner Student Advisory Committee Meeting I Sun, March 5 6:45 PM to 7:15 PM San Diego Convention Center Room 14B Student Advisory Committee Meeting II Tue, March 7 7:00 AM to 8:30 AM San Diego Convention Center Room 12 Student In Vitro Toxicology Lecture & Luncheon Tue, March 7 12:00 NOON to 1:15 PM San Diego Convention Center Room 33 (Ticket Required) Student/Post-Doctoral Fellow Mixer Sun, March 5 7:30 PM to 8:30 PM San Diego Convention Center Room 33 (Ticket Required) Taylor and Francis Reception Mon, March 6 5:00 PM to 7:00 PM Marriott Hotel & Marina Marina Ballroom F Technical Committee Meeting of the Inhalation Wed, March 8 7:00 AM to 8:30 AM San Diego Convention Center Room 3 Specialty Section Telemetry in Toxicology: When is it Appropriate? Tue, March 7 11:30 AM to 1:00 PM Marriott Hotel & Marina Marina Ballroom F presented by Data Sciences International
(By Invitation Only) EVENT CALENDAR Town Hall Meeting Session—Recent Changes in Wed, March 8 4:30 PM to 6:00 PM San Diego Convention Center Room 6F Participation Requirements on Government Advisory Groups/Panels ToxExpoTM 2007 Exhibit Space Selection Meeting Tue, March 7 4:45 PM to 6:00 PM San Diego Convention Center Room 11A Toxicogenomics Solutions Using Illumina’s Tue, March 7 12:15 PM to 1:15 PM San Diego Convention Center Room 11B BeadArray Technology presented by Illumina (Informational Session) Toxicologic and Exploratory Pathology Specialty Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 16A Section Meeting/Reception Toxicologic and Exploratory Pathology Specialty Mon, March 6 6:30 AM to 8:00 AM San Diego Convention Center Room 17A Section Officers Meeting Toxicological Sciences Associate Editors Meeting Sun, March 5 11:00 AM to 3:00 PM Marriott Hotel & Marina Cardiff Room Toxicological Sciences Dinner (By Invitation Only) Mon, March 6 7:30 PM to 10:00 PM Candelas Restaurant 416 3rd Avenue Toxicology Education Foundation Trustees Sun, March 5 9:00 AM to 11:30 AM Marriott Hotel & Marina Newport Beach Room Meeting ToxLearn Work Group Tue, March 7 10:00 AM to 11:30 AM San Diego Convention Center Room 19 Undergraduate Education Program— Sat, March 4 6:15 PM to 8:45 PM San Diego Convention Center Room 16A Lecture/Reception Undergraduate Education Program Sat, March 4 5:30 PM to 6:00 PM San Diego Convention Center Room 19 Orientation for Hosts, Peer Mentors and Advisors Undergraduate Education Program Sun, March 5 8:00 AM to 5:00 PM San Diego Convention Center Room 16A Undergraduate Education Program Mon, March 6 8:00 AM to 2:00 PM San Diego Convention Center Room 16B Understanding Your Pharmacological Target Tue, March 7 11:00 AM to 12:00 NOON San Diego Convention Center Room 11A Distribution Across Normal and Diseased Human and Animal Tissues presented by Gene Logic (Informational Session) University of Louisiana TOX Breakfast Tue, March 7 6:50 AM to 8:00 AM Marriott Hotel & Marina Cardiff Room University of Rochester Toxicology Alumni Tue, March 7 7:30 PM to 10:00 PM Marriott Hotel & Marina Manchester Room Reception Using Animals for Toxicological Research Mon, March 6 4:30 PM to 6:00 PM San Diego Convention Center Room 1A and Testing (Special Session) Using Histological Evaluation to Enhance Wed, March 8 1:30 PM to 2:30 PM San Diego Convention Center Room 11A the Bovine Cornea Opacity and Permeability (BCOP) Assay for Ocular Irritation presented by Institute for In Vitro Sciences (Informational Session) VIP ToxExpoTM Exhibit Hall Walk-Through Mon, March 6 1:30 PM to 2:30 PM San Diego Convention Center Exhibit Hall Welcoming Reception Sun, March 5 6:30 PM to 7:30 PM San Diego Convention Center Sails Pavilion Celebrating 45th Anniversary (All Attendees Welcome) Women in Toxicology Specialty Tue, March 7 7:00 AM to 8:00 AM San Diego Convention Center Room 10 Section Officers Meeting Women in Toxicology Specialty Section Tue, March 7 6:00 PM to 7:30 PM San Diego Convention Center Room 10 Meeting/Reception WWW Advisory Committee Focus Group Tue, March 7 11:45 AM to 1:30 PM San Diego Convention Center Room 16B Luncheon (By Invitation Only) WWW Advisory Committee Meeting Wed, March 8 7:00 AM to 8:30 AM San Diego Convention Center Room 12 up-to-date information at www.toxicology.org 11 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo
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egistration is located on the the on located is egistration
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Sails Pavilion (Ground Level) Business Center FedexKinkos 33–34 Across from Exhibit Hall D Rooms
12 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo S an Di eg o Conventi on Center M e z z a ni ne Level SOT Office/ Speaker Ready Room
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E W MAPS Security (upstairs) G r ound L e v el N More detailed map of Exhibit Hall on page 23.
ToxExpoTM Show Management Office and First Aid (upstairs) Restrooms Restrooms Restrooms
A Marriott B1 Exhibit Hall Hotel & B2 ToxExpoTM Marina (adjacent) Exhibit Hall Exhibit Hall
Restrooms
Starbucks Tour Desk
Restaurant FedexKinkos Harbor Drive Information Center Business Center Restrooms Harbor Drive Message Center/Housing Desk Registration Desk Luggage Check up-to-date information at www.toxicology.org 13 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo San Diego Hotel Accommodations 1. Embassy Suites Hotel 4. Marriott Hotel & Marina* 6. Quality Inn & Suites San Diego Bay 333 West Harbor Drive (Government Rate Rooms 601 Pacific Avenue San Diego, California 92101 Only; ID required) San Diego, California 92101 Tel: (619) 234–1500 1430 Seventh Avenue Tel: (619) 239–2400 Fax: (619) 234–8678 San Diego, California 92101 Fax: (619) 696–9184 www.marriott.com/sandt Tel: (619) 696–0911 or www.embassysuites.com Rating: 4-Diamond tttt (800) 404–6835 Rating: 4-Diamond tttt Club: Marriott Fax: (619) 234–9416 Club: Hilton Adjacent to the Convention www.qualityinnsandiego.com 4 blocks from the Convention Center Rating: 3-Diamond ttt Center Club: Choice Approx. 1 mile to the Convention Center ($6 cab fare to Convention Center) 5. Omni San Diego 2. Hampton Inn by Hilton 675 L Street San Diego Downtown San Diego, California 92101 1531 Pacific Highway Tel: (619) 231–6664 San Diego, California 92101 Fax: (619) 231–8060 7. Residence Inn by Marriott Tel: (619) 233–8408 www.omnihotels.com San Diego Downtown Fax: (619) 233–8418 Rating: 4-Diamond tttt 1747 Pacific Highway MAPS www.SanDiegoHamptonInn. Club: Omni San Diego, California 92101 com 1⁄2 block from the Convention Tel: (619) 338–8200 Rating: 3-Diamond ttt Center Fax: (619) 338–8219 Club: Hilton www. SanDiegoResidenceInn. Approx. 1 mile from the com Convention Center Rating: 3-Diamond ttt Club: Marriott Approx. 1 mile from the Convention Center
3. Manchester Grand Hyatt* One Market Place San Diego, California 92101 Tel: (619) 232–1234 Fax: (619) 233–6464 www.manchestergrand.hyatt. com *Co-Headquarter Hotels Rating: 4-Diamond tttt Club: Hyatt 1 1⁄2 blocks from the Convention Center
14 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Downtown San Diego MAPS
SOT Annual Meeting
111 WEST HARBOR DRIVE, SAN DIEGO, CA 92101 PHONE (619) 525–5000 • FAX (619) 525–5005 WWW.VISITSANDIEGO.COM
up-to-date information at www.toxicology.org 15 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Manchester Grand Hyatt
Ground Level MAPS
16 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Manchester Grand Hyatt
Entrance from level one (First Floor) Second Floor
Third Floor MAPS
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up-to-date information at www.toxicology.org 17 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Marriott H otel & Marina
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SOT Guest Hospitality Center Manchester Guest Rooms Elevator Registration
Columbia Rooms Torrey Rooms West Lobby Seaview Lounge
Elevator to Exhibit Hall South Tower North Tower Chicago DW’s pub DW’s lounge Atlanta Anaheim
San Diego San Diego FoyerBallroom Marriott Escalator Elevators East Hall Drive Parking Lobby Starbucks Lounge
Escalator to Guest Convention Center Registration Bell Stand & Business Center Gift Concierge Marriott Shop Hall Gift Shop Loading Entrance Gift Hotel Entrance Shop New York Orlando San Francisco MAPS Lobby Level
Yacht Club Restrooms/Ice Machine Restaurant Restrooms/Ice Machine To Seaport Guest Coin Laundry Village Restrooms/Ice Machine & Bar
Elevator Pool Pool Marina Office LC’s Restaurant Solana Elevator to Marriott Hall Point Loma Elevators Pacific CRAD Oceanside Services Parking Leucadia (3 Levels) Elevators Laguna Molly’s Business Restaurant & Bar Center Escalator Exhibit Hall & Parking Garage Santa Rosa
Walkway to Convention Center Fir st Floor
18 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Marriott Hotel & Marina
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Third Floor up-to-date information at www.toxicology.org 19 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo San Diego Restaurants MAPS
20 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo San Diego Restaurants Restaurants within Eight Blocks of Convention Center
$=$10
(619) 238–8100 $ (619) 239–3222 $$
(619) 702–5024 $$$ (619) 237–6186 $$$
(619) 234–8000 $$ (619) 702–7101 $$$ (619) 234–5555 $$$+ (619) 230–8995 $$
(619) 232–3888 $$$ (619) 233–7391 $$ (619) 239–9994 $$ (619) 645–6545 $$$ (619) 557–0146 $$+ (619) 696–0234 $$ (619) 230–8888 $$ (619) 234–6333 $$
(619) 233–1653 $$$ (619) 233–7800 $$
(619) 230–0382 $$ (619) 238–5440 $$$+
(619) 231–9100 $+ (619) 234–1955 $$+
(619) 230–1968 $$ (619) 233–4355 $$$+ MAPS
(619) 358–6740 $$$ (619) 615–7625 $$ (619) 233–4300 $ (619) 238–0101 $$ (619) 232–1141 $$$ (619) 238–0203$–$$$ (619) 232–7581 $$ (619) 338–0008 $$ (619) 230–8424 $$
(619) 232–8226 $ (619) 235–8500 $$$
(619) 702–5595 $$ (619) 234–5554 $$$
(619) 232–9840 $+ (619) 702–8464 $$
(619) 544–9779 $$$ (619) 231–6771 $$+
(619) 235–4668 $ (619) 233–5757 $$+ (619) 232–4242 $$ (619) 231–9680 $ (619) 235-8144 $$$ (619) 595–0115 $+ (619) 233–7272 $$ (619) 232–3474 $$ (619) 239–1235 $$$ (619) 234–4867 $$$$ (619) 595–7959 $$$
(619) 232–8844 $$$ Visit the SOT 2006 Annual Meeting Web site at www.toxicology.org for a full listing of Downtown San Diego Restaurants.
up-to-date information at www.toxicology.org 21
Annual Meeting Annual th
SOT's 45 SOT's resource for the scientist, scientist, the for resource to see which companies companies which see to the educator, the student— the educator, the
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map of Concessions Exhibit Itinerary Concessions (upstairs) ToxExpoTM Show Planner Restrooms Restrooms Management Office
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Membership 45th AnnualMeetingandToxExpo Booth (1736)
TM in the Exhibit Hall inthe Exhibit Meeting & ToxExpo 23 POSTERS POSTERS POSTERS 45 th Wireless Internet Access Annual
CRAD Interview Room 200
CRAD Interview Room Additional 201 CRAD Job Bank ToxExpo Meeting Center Room Interview 202 Rooms
ToxExpo Meeting Room 203
MEN Escalator/ Message Center/Housing Desk Stairs to Upper Stairs/ Level Elevators
Restaurant Information Center Luggage Check Entrance Restrooms Registration Starbucks Tour Desk Internet Cafe
TOXEXPO 336 548 438 539 722 408 301 609 708 333 431 320 918 821 409 842 349 533 800 741 434 535 948 851 346 324 802 847 309 321 814 513 809 630 631 731 831 711 818 801 1524 1138 1213 1511 1352 1200 1023 1137 1124 1607 1101 1403 1203 1021 1449 1405 1222 1216 1210 1117 1208 1714 1706 1401 1619 1236 1312 1005 1407 1503 1047 ...... Booth Number Annual Meeting Annual th SOT's 45 SOT's
Annual Annual Substances and Disease (CDC/ATSD) ...... (CDC/ATSD) Substances and Disease th Hazardous Materials Information Review Commission (HMIRC) .. Hazardous Materials Information Review Commission (HMIRC) ...... Hemo Genix Inc...... Hilltop Lab Animals, Inc...... HistoRx, Inc...... Humana Press ...... Huntingdon Life Sciences ...... Hurley Consulting Associates Ltd...... ICT–XI ...... Illumina, Inc...... ILSI Health and Environmental Sciences Institute Colonial Medical Supply ...... Colonial Medical Supply ...... Colorado Histo-Prep ...... CombiMatrixCorp ...... Comparative Biosciences ...... CompuCyte Corporation ...... CorDynamics ...... Cosmetic Ingredient Review ...... Covance ...... Data Integrated Scientific Systems (D.I.S.S.) ...... Data Sciences International ...... Definiens AG ...... Detroit R & D, Inc...... DiLab, Inc...... Ellegaard Göttingen Minipigs ...... Elm Hill Breeding Labs, Inc...... Elsevier Science Inc...... EMKA TECHNOLOGIES ...... Environmental Health Perspectives (EHP) EPL, Inc. (Experimental Pathology Laboratories) ...... Experimur ...... Expression Analysis ...... Fraunhofer ITEM ...... Gamma Medica Ideas ...... Gene Logic, Inc...... Genedata Inc...... GeneGo, Inc...... Gentronix Limited ...... Harlan Company Name ...... Company Name ...... Inc. Carl Zeiss MicroImaging, ...... Cayman Chemical ...... Cellomics, Inc...... CellzDirect ...... Animals (CIEA) Central Institute for Experimental ...... CEREP ...... ChemRisk ...... CLEA Japan, Inc ...... Clinical Data, Inc...... CIIT Centers for Health Research ...... Ciphergen Biosystems, Inc...... CIT Gene Tools ...... Gene Tools Charles River Laboratories Pathology Services ...... Pathology ServicesCharles River Laboratories ...... Charles River Laboratories Preclinical Services ...... Charles River Laboratories Clinical Services ...... Products Inc. Covance Research Gwathmey, Inc...... Inc. Gwathmey, ...... Inc. (IVT) Technologies, In Vitro Centers for Disease Control and Prevention/Agency for Toxic and Prevention/Agency for Toxic Centers for Disease Control ...... Inc. ChanTest, .. Research Models & ServicesCharles River Laboratories ...... Dow Corning Corporation Exygen Research ...... Exygen Research ...... Inc. Genpathway, ...... GlobalTox ...... Hamilton Thorne Research ...... LLC Hamilton-Kinder, ...... Institute IIT Research ...... Inc. Ina Research CeeTox Inc...... Inc. CeeTox ...... Laboratory—Syngenta Central Toxicology ...... (USA) Inc. CH Technologies 45 24 Meeting & ToxExpo & Meeting
707 808 300 841 700 420 618 437 201 404 406 401 619 433 231 620 449 436 622 303 601 530 520 421 638 642 435 318 836 407 820 432 930 525 718
1025 1205 1125 1019 1624 1123 1300 1621 1119 1519 1234 1131 1631 1614 1223 1109 1724 1604 1152 1611 1507 1244 1505 1100 1606 TM ...... ToxExpo Booth Number ...... TM
(As of January 1, 2006) of complete sponsors on Inside Foldout. or the www.ToxExpo.com 45th Annual Meeting and ToxExpo and Meeting Annual 45th locations, and other information. for product/service descriptions, a map of booth Alphabetical Listing Alphabetical
See listing Please visit
2006 Annual Meeting sponsors are in bold. Directory Cantox Health Sciences International ...... Cantox Health Sciences International Burdock Group ...... Burdock Group ...... Cambrex BioStat Consultants Inc ...... BioStat Consultants Inc ...... Biotechnics, LLC ...... Biotrin International ...... Brady Corporation ...... Bristol-Myers Squibb Company (BMS) BIOAGRI PHARMA ...... BIOAGRI PHARMA ...... Biolog, Inc. BioLife Solutions ...... BioLife Solutions ...... Bio Medic Data Systems Inc. BBL Sciences ...... BBL Sciences ...... BD Biosciences ...... Beckman Coulter ...... Bench International ...... BioE, Inc. B.I.K. Industries ...... B.I.K. Industries ...... BASi (Bioanalytical Systems, Inc.) ...... Battelle HHS APTUIT (Allendale) Inc...... APTUIT (Allendale) Inc. Animal Identification and Marking System, Inc. (AIMS) Animal Identification and Marking System, Inc...... Antech Diagnostics ...... Applied Biosystems Americans for Medical Progress (AMP) ...... Americans for Medical Progress (AMP) ...... Amgen ...... Anilab, Inc. ALZET® Osmotic Pumps/DURECT Corp...... ALZET® Osmotic Pumps/DURECT Corp. Advinus Therapeutics Pvt Ltd ...... Advinus Therapeutics Pvt Ltd ...... Affymetrix ...... Allentown Caging Equipment CO. Inc. ACGIH ...... ACGIH ...... ADMET GROUP ...... Adriadne Genomics Company Name ...... Company Name ...... 3E Company ...... AAALAC International 2006 Exhibitors 2006 Buxco Research Systems ...... Systems Buxco Research Althea Technologies ...... Althea Technologies ...... American Association for Laboratory Animal Science (AALAS) ...... (ABT) American Board of Toxicology ...... (ACT) American College of Toxicology ...... Inc. Ani Lytics ...... Aperio Technologies ...... Biosciences Aviva ...... Bio-Serv Inc...... Ltd BioDynamics Research Access Technologies ...... Access Technologies ...... ADMET Technologies ...... Agilent Technologies ...... & Development Alabama Research BioReliance, Invitrogen Bioservices ...... Calvert Laboratories, Inc...... Cantest BioPharma Services. Applied Preclinical Services ...... Applied Preclinical Services ...... Laboratory Services AppTec ...... GmbH. ARC Seibersdorf research ...... Arcturus ...... Biomedical, Inc. AVA ...... Company BioLogix Research ...... Center Biological Test
TOXEXPO Korea InstituteofToxicology (KIT) ...... Jai Research FoundationInternational ...... AnimalResearchInstitute forLaboratory (ILAR) ...... Ricerca Biosciences ...... Research Diets,Inc...... L.L.C.(QPS) Quest PharmaceuticalServices, ...... Pharmalytica Services Scientific Perry ...... ofMedicine ...... National Library Midwest Research Institute ...... Midwest BioResearch ...... MDS PharmaServices MB Research Labs,Inc...... Marshall BioResources ...... Q-Test ...... Progenix Research SdnBhd ...... Perceptive Instruments ...... Nucro-Technics ...... NOTOX B.V...... National Toxicology Program(NTP) ...... National CenterofToxicogenomics ...... ResearchLovelace Respiratory Institute(LRRI) ...... LABCAT ...... Kforce ScientificStaffing ...... John Wiley &Sons ...... JCL Bioassay, Inc...... International UnionofToxicology (IUTOX) ...... Integrated Telemetry (ITS) Services ...... Nerviano MedicalSciencessrl Nerviano ...... up-to-date information at www.toxicology.org information up-to-date ReCathCo LLC ...... RCC Ltd...... Risk AssessmentSummerSchool(RASS) ...... Purina MillsLabDiet ...... Promega Corp ...... Product SafetyLabs ...... Primate Products,Inc.(PPI) ...... Primanova ...... PreclinOmics ...... Popper &Sons,Inc...... Physio Genix ...... Phylonix ...... Pharma Algorithms ...... Pfizer GlobalResearchandDevelopment ...... Pathology DataSolutions,Inc...... Partek Incorporated ...... Oxford UniversityPress ...... Notocord Systems ...... Northview Biosciences ...... Neuroscience Associates(NSA) ...... NIEHS/OCPL ...... MultiCASE, Inc...... MPI Research ...... Mouse Specifics,Inc...... MicaGenix ...... Metabometrix Ltd ...... Med Associates ...... Lomir Biomedical,Inc...... Loats Associates,Inc...... LHASA Limited ...... Leadscope Inc...... LDS LifeScience ...... LabCorp Preclinical ...... LabCorp ...... LAB Products,Inc...... Kent ScientificCorporation ...... Kamiya BiomedicalCompany ...... ITR LaboratoriesCanada,Inc...... ISIS BioComp ...... IPS Therapeutique,Inc...... Institute ForInVitro Instem LSS ...... Instech Solomon ...... Company Name ...... 2006 Exhibitors 45th AnnualMeetingandToxExpo Sciences(IIVS) ...... Booth Number (Continued) 1625 1001 1610 1003 1049 1118 1136 1425 1431 1718 1423 1330 1253 1102 1150 1615 1605 1720 1146 1439 1120 1106 1348 1447 1113 1148 1515 1525 1518 1520 1122 1238 1103 1202 330 337 501 743 403 522 500 737 750 217 549 547 305 810 536 425 519 307 640 400 439 538 950 537 532 649 719 322 725 331 723 430 717 335 506 747 944 648 Meeting & ToxExpo 25 45 XenoTech, LLC ...... XCELLON—The AEgisTechnologies Group,Inc...... VivoMetrics Inc...... Vitrocell Systems ...... VisualSonics ...... UTAK Laboratories,Inc...... U.S. EPA, OfficeofResearch andDevelopment ...... U.S. EnvironmentalProtectionAgency(EPA) ...... Trevigen ...... ToxServices LLC ...... Toxikon Corporation ...... Toxicology Research Laboratory ...... Toxicology ExcellenceforRiskAssessment ...... Toxicology EducationFoundation(TEF) ...... Thomson ResearchSoft ...... Talos MSDSAuthoringandDistributionSoftware ...... Taconic ...... Stillmeadow, Inc...... StemCell Technologies, Inc...... Springborn SmithersLabs/SynergyPharmaServices ...... RTC, Research Toxicology CentreS.p.A...... Vitron Inc ...... Viking Medical/UsedCaging.com ...... Veritox, Inc...... Tox Monitor/BSR,Inc...... Taylor &Francis ...... Tandem Labs ...... Southern Research Institute ...... SOT—Animals inResearch ...... SNBL USA,LTD...... Sinclair Research Center, Inc...... Equipment) SCIREQ, Inc.(ScientificRespiratory ...... Wildlife InternationalLtd...... U.S. EPA, OfficeofPollutionPrevention&Toxics ...... Toxicology Services Regulatory ...... SOT—RALA ...... SOT—Membership ...... SOT—K–12 Education ...... SoBran Inc...... Smiths MedicalMD,Inc...... Siemans MedicalSolutionsUSA ...... SFBC International ...... SeraCare LifeSciences,Inc...... Sequani Limited ...... Scantox A/S ...... San DiegoInstruments,Inc...... Sage Publications ...... Safepharm LaboratoriesLtd ...... RTI International ...... Rosetta Biosoftware ...... Company Name ...... Xybion MedicalSystems ...... Xenobiotic DetectionSystems ...... WIL ResearchLaboratories ...... TSI TSE Systems,Inc...... TNO ...... The LeydenGroup ...... Suburban SurgicalCompany ...... Strategic Applications,Inc...... SRI International ...... th ...... Annual Special requests canbebrought totheShowManager. Admittance totheExhibitHallislimited Photography isprohibited intheExhibitHall. intheExhibitHall (seemaponpage23). Children undertheageof15years TheShowManagement Officeislocated
are notallowedintheExhibitHall. attendees withfullregistration.
Booth Number
1710
1037 1218 1145 1220 1201 1501 1302 1308 1451 1031 1538 1204 1248 1231 1734 1736 1742 1740 1506 1239 1252 1053 1246 1500 1230 1419 1217 1209 701 551 709 621 819 940 524 316 550 453 212 646 812 623 523 715 308 636 840 922 724 624 423 823 422 534 531 450 704 323 650
TOXEXPO th REGISTRATION 45 Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Registration Annual Meeting Registration Annual Meeting Includes: Registration Fees: • San Diego University Choral Scholar Performance, On-Site Sunday, March 5 at 4:45 PM. SOT Member ...... $350 • Awards Ceremony Celebrating 45th Anniversary, Non-Member ...... $600 Sunday, March 5 from 5:15 PM–6:30 PM. SOT Retired Member ...... $145 • Welcoming Reception Celebrating 45th Anniversary, Post-Doctoral SOT Member ...... $160 Sunday, March 5 from 6:30 PM–7:30 PM. Post-Doctoral Non-Member ...... $240 • Plenary Lecture, Monday, March 6 from Graduate Student SOT Member ...... $140 8:30 AM–9:15 AM. Graduate Student Non-Member ...... $200 • All Scientific Sessions (see program descriptions Undergraduate Student ...... $140 beginning on page 57) 9:30 AM, Monday, March 6 SOT Affiliate ...... $ 0 through 12:00 NOON, Thursday, March 9. Press ...... $ 0 • ToxExpo™ Exhibit Hall, 9:30 AM Monday, March 6 Guest (Non-Scientist) ...... $100 through 4:30 PM Wednesday, March 8. (Guests do not have member or registrant privileges) Participants are also encouraged to register for the Con- tinuing Education Courses. These are available during three Continuing Education Course time intervals on Sunday, March 5: the Sunrise Mini-Course is from 7:00 AM–7:45 AM; morning courses are 8:15 AM–12:00 Fees: (per AM or PM course) NOON; and afternoon courses are from 1:15 PM–5:00 PM. (Only Annual Meeting Registrants may enroll in CE Courses) Registration Desk On-Site Registration Desk will be located in Hall A Lobby. SOT Member/SOT Affiliate ...... $150 Registration Desk Hours: Retired ...... $145 Saturday ...... 4:00 PM–7:00 PM Non-Member ...... $250 Sunday ...... 7:00 AM–8:00 PM Post-Doctoral (SOT Member or Non-Member) ...... $125 Monday ...... 7:00 AM–5:00 PM Graduate or Undergraduate Student Tuesday ...... 8:00 AM–4:00 PM (SOT Member or Non-Member) ...... $ 80 Wednesday ...... 8:00 AM–4:00 PM Press ...... $ 0 Thursday ...... 8:00 AM–11:30 AM
Continuing Education Sunrise Registration Materials Mini-Course Fees: Register before February 7, 2006, and your badge and (includes continental breakfast) registration materials will be sent to you three weeks On-Site prior to the Annual Meeting. Your 2006 Annual Meeting SOT Member/Affiliate ...... $ 95 Registration badge must be presented to obtain access to SOT functions. Post-Doctoral (SOT Member or Non-Member) ...... $ 95 Retired ...... $ 95 When you arrive at the San Diego Convention Center, Non-Member ...... $115 please pick up a badge holder. You do not need to wait in the registration line if you already have a badge. Your Graduate or Undergraduate Student ...... $ 65 2006 Annual Meeting registration badge must be pres- Press ...... $ 0 ented to obtain the registration materials (i.e., The Toxicologist on CD-ROM, the ToxExpoTM Directory and other supplementary materials).
26 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information th 45 Anniversary Raffle Contest Exhibit Hall (Hours/Location) GENERAL INFO SOT 45th Anniversary Raffle Contest will be held in the Exhibit hours at the Convention Center are as follows: Exhibit Hall Monday, Tuesday, and Wednesday between Monday ...... 9:30 AM–4:30 PM 12:00 NOON and 1:30 PM. As part of the 45th Anniversary Tuesday ...... 8:30 AM–4:30 PM Celebration, SOT will be giving away a total of $4500 over a three-day period! More details and contest rules are on Wednesday ...... 8:30 AM–4:30 PM the SOT Annual Meeting Web site at www.toxicology. A map of the Exhibit Hall is located on page 23. Exhibitor org and in the Exhibit Hall on-site. personnel and poster presenters may enter the Hall one hour before the Exhibit Hall opens with appropriate identification. Accessibility for Persons with Disabilities Exhibit Hall Policy Admittance to the Exhibit Hall is limited to attendees with The San Diego Convention Center and most of the SOT full registration. Guest Registrants and Children under the hotels are accessible to persons with special needs. If you age of 15 years of age are not allowed in the Exhibit Hall. require special services, please mark the appropriate box on the Housing Request Form and the Registration Form. Photography is prohibited in the Exhibit Hall. Special requests If you require more information about disabled access, can be brought to the Show Manager. The Show Management please contact Heidi Prange at SOT Headquarters: (703) Office is located in Exhibit Hall A, back right corner, upstairs. 438–3115 Ext. 1424 or E-mail: [email protected]. First Aid Attire If an emergency occurs at the San Diego Convention The official attire for the Annual Meeting is business Center, proceed to the nearest house phone in the foyer casual. No coat or tie is required! We encourage you to areas throughout the Center and dial 5911 or 5490. You bring comfortable clothing and extra shoes. will be connected to Security/Guest Services. These num- bers are accessible 24 hours a day. Badges SOT will also provide a First Aid Office that will be open during exhibit move-in, move-out, and scientific session Annual Meeting attendees who have registered before hours. The First Aid Office is located in the Show Manage- February 7, 2006 will receive badges and registration ment Office at the back right corner of Exhibit Hall A, materials in the mail. If you already have your 2006 upstairs. First aid is provided by First Aid Services of San Diego. Annual Meeting badge you do not need to wait in the registration line. Convention Center First Aid Office hours: If you have not registered for the meeting, please complete Saturday ...... 3:00 PM–8:00 PM the on-site registration form and proceed to the appro- Sunday ...... 7:00 AM–8:00 PM priate registration line. Monday ...... 7:00 AM–6:00 PM Tuesday ...... 7:00 AM–6:00 PM Business Center Wednesday ...... 7:00 AM–10:00 PM Thursday ...... 8:30 AM–11:30 AM A FedEx Kinko’s office and print center is located in Hall D Lobby of the San Diego Convention Center. Hours of operation are Monday–Friday, 8:00 AM–5:00 PM; Food Services Saturday–Sunday, 9:00 AM–5:00 PM. Contact Debbie Nunez, Convention Services Manager at (888) 215–1857 Coffee Breaks or E-mail [email protected]. The business service center offers shipping, mailing, photocopying, The Exhibiting Companies are pleased to sponsor comp- binding, computer rentals, and e-mail access. limentary coffee in the Exhibit Hall between 9:30 AM– 10:30 AM, Monday through Wednesday. See Exhibit Hall signage for locations. up-to-date information at www.toxicology.org 27 th GENERAL INFO GENERAL 45 Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information (Continued) Concessions Did you know that your choice of hotel for the SOT Annual Meeting has a direct impact on the Society’s Long-Range Concession stands are available during Exhibit Hall Plan initiatives? Although we understand that making hours. Exhibit hours are listed under Exhibit Hall in the your reservations outside of the SOT block can sometimes General Information Section. Breakfast and lunch items be more economical, it decreases the money available to are available, as well as coffee, soda, bottled water, and the Society to carry out its long-term goals and may cause snacks for purchase. the Society to have to pay attrition fees for unutilized rooms. In addition, the Society is unable to assist you Restaurants if you have any difficulties with your room reservation, such as the hotel over-booking or misplacing your reser- A Restaurant Information Center will be located in the vation. Hall B2 Lobby on the Ground Level of the San Deigo Convention Center. Restaurants located within eight SOT depends on the Annual Meeting revenue to fund blocks of the Convention Center are located on pages 20 other programs throughout the year and to keep future and 21 with a map of downtown San Diego. A full listing of registration fees low. Please assist the Society by making restaurants by cuisine and price can be viewed on the SOT your hotel reservation through the San Diego Housing Annual Meeting Web site at www.toxicology.org. Bureau.
Guest Hospitality Center Housing Desk For information regarding your hotel room reservation, and Program please visit the SOT Housing Desk located in Hall B Lobby The SOT Guest Hospitality Center provides guest parti- on the Ground Level of the Convention Center. The cipants (non-scientists) with a place to meet and socialize deadline for housing reservations is February 8, 2006. with other guests. To visit the Hospitality Center, guests Housing Desk hours: must register for the Annual Meeting using the same Registration Form as the person they are accompanying. Saturday ...... 4:00 PM–7:00 PM Guests are welcome to attend the Welcoming Reception Sunday ...... 7:00 AM–5:00 PM Celebrating the 45th Anniversary of SOT, but will not have Monday ...... 7:00 AM–5:00 PM access to the scientific sessions or the Exhibit Hall. Please Tuesday ...... 8:00 AM–4:00 PM remember to wear your badge to all SOT events. Wednesday ...... 8:00 AM–4:00 PM The Guest Hospitality Center will be located in the Thursday ...... 8:00 AM–11:30 AM Manchester Room at the Marriott Hotel & Marina.
Guest Hospitality Center hours: Methods for Making Housing Reservations Sunday ...... 8:00 AM–4:30 PM On-Line Telephone Monday ...... 8:00 AM–4:30 PM www.toxicology.org Toll-Free (USA): (800) 676–5026 Tuesday ...... 8:00 AM–4:30 PM International: (330) 405–7884 Wednesday ...... 8:00 AM–4:30 PM Fax Mail Thursday ...... 8:00 AM–11:30 AM (330) 963–0319 SOT Housing Bureau 2451 Enterprise Parkway East Twinsburg, OH 44087 Housing Information and United States Reservations E-mail [email protected] The Society of Toxicology has reserved discounted room rates at various San Diego hotels—known as the SOT hotel block for SOT Annual Meeting attendees. This block includes discounted room rates at many premier hotel chains. In order to secure these discounted room rates, you will need to make your hotel reservation through the San Diego Housing Bureau. 28 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information (Continued) Luggage Check hours: Internet Access and GENERAL INFO Sunday ...... 7:00 AM–8:30 PM Electronic Devices Monday ...... 7:00 AM–8:30 PM As technology advances, SOT realizes how important it Tuesday ...... 7:00 AM–8:00 PM is for attendees to learn the latest scientific discoveries at Wednesday ...... 7:00 AM–8:00 PM the meeting while using technology to stay connected Thursday ...... 7:00 AM–1:00 PM to daily responsibilities. SOT will have stations available in the Hall B Lobby (Message Center) and ToxExpoTM to Luggage check hours are subject to change. check your e-mail and connect to the Internet. In addi- tion, “Hot Zones” in the Exhibit Hall will offer wireless Internet access via your personal laptop computer or other Media Support Services devices. These areas will be clearly marked with bright The Society of Toxicology welcomes accredited represen- signage. Please look at the Exhibit Hall map on page 23 tatives of media organizations. Journalists may receive for designated areas. complimentary credentials for all meeting sessions, as well as a complete media kit, by contacting Lilly Instructions for Wireless Internet Access Richards at SOT Headquarters: (703) 438–3115 or E-mail: [email protected]. On-site, media kits can be picked up To access the wireless connection: at the SOT Headquarters Office, Room 14A, in the San Diego Convention Center. 1. Open your wireless software on your computer and view available wireless networks. 2. Look for a wireless network called ToxExpo2006. For Memorabilia most configurations, you will highlight ToxExpo2006 Shirts, portfolios, and other items customized for SOT and select Connect. are available for order on-line to pick up at the Annual 3. No password is required to use this wireless Internet Meeting. Visit the SOT Web site at www.toxicology.org connection. or contact SOT Headquarters to request an order form. Merchandise will also be available for sale at the Annual Meeting in the Memorabilia Booth in the Upper Level Electronic Devices Ballroom 6 Lobby of the San Diego Convention Center. As a courtesy to meeting attendees, electronic devices must be operated in silent/vibrate mode within scientific sessions; devices that beep, ring, etc., are prohibited. Message Center Silence is golden. Please do not conduct cell phone This year you will be able to send and recieve messages conversations while attending a scientific session. Your electronically. The Message Center will be located in cooperation is appreciated. Hall B Lobby on the Ground Level of the Convention Center and is designed to facilitate interaction among the attendees during the Annual Meeting. SOT members, Lost and Found CRAD Job Bank registrants, and Annual Meeting atten- Lost and found articles may be brought to the SOT Head- dees will have access to the Annual Meeting Message quarters Office, Room 14A, of the San Diego Convention Center through a direct link from the SOT Web site using Center. Any items left in the SOT Headquarters Office the computers at the Message Center or any computer after 11:30 AM, Thursday, March 9 will be deposited at with an Internet connection. The telephone number to the Security Office at the Convention Center. the Message Center is (619) 525–6250. Message Center hours: Luggage Check Saturday ...... 4:00 PM–7:00 PM Sunday–Monday ...... 7:00 AM–5:00 PM For your convenience, a luggage check area will be located in Hall B2 Lobby in the San Diego Convention Center. Tuesday–Wednesday ...... 8:00 AM–4:00 PM There will be a fee of $2.00 per item checked and laptop Thursday ...... 8:00 AM–11:30 AM computers will be accepted as long as they are in a case. up-to-date information at www.toxicology.org 29 th GENERAL INFO GENERAL 45 Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information (Continued) Photography Policy • In the unlikely event that outsiders disrupt a scientific session or other event, SOT security officials Photography of scientific presentations and poster presen- have developed a contingency plan. Please follow tations is prohibited without the specific consent of the directions from the chairperson and avoid becoming presenter(s)/author(s). Session chairs are asked to strictly involved in the situation. enforce this policy and individuals who do not comply will be asked to leave the session. In addition, cameras and Other Safety Actions Include: recording devices are prohibited in the Exhibit Hall. If you have any questions regarding this policy, please see Show • Walk “smart” when you leave the Convention Center. Manager, located in the Exhibit Hall, right back corner, • Know your destination and the best way to reach it. upstairs. • Travel along sidewalks in lighted areas at night, and don’t walk alone. Registration • Establish a “buddy” system with another delegate to Full registration details may be found on page 26. the convention. • Share schedules and check up on each other Registration Desk Hours periodically. • Build your awareness of unknown surroundings by The Annual Meeting Registration Desk is located in the reviewing local information. San Diego Convention Center Lobby A. Registration Desk hours: • Laptop computers are attractive, easy targets for thieves. Be sure your laptop is in a secure place. Saturday ...... 4:00 PM–7:00 PM Sunday ...... 7:00 AM–8:00 PM • Jackets with pockets provide a convenient alternative Monday ...... 7:00 AM–5:00 PM for women to reduce the chance for lost or stolen handbags. Tuesday ...... 8:00 AM–4:00 PM Wednesday ...... 8:00 AM–4:00 PM Our first priority is safety. The best way to stay safe is Thursday ...... 8:00 AM–11:30 AM to be aware of your surroundings and to avoid situations where you feel uncomfortable. Safety and Security SOT Headquarters Office The possibility of demonstrators is very real given the nature of our conference. Events of this kind range The SOT Headquarters Office is located in the San Diego from verbal confrontations, protests, strikes, to riots. We Convention Center, Room 14A. recommend the following procedures in the event of SOT Headquarters Office hours: demonstrations: Saturday ...... 4:00 PM–7:00 PM • Have your name badge available upon entering the Sunday ...... 7:00 AM–5:30 PM Convention Center. Wear your name badge in the Convention Center. When leaving the facility, remove Monday ...... 7:00 AM–5:00 PM it so as to blend with other people. Tuesday ...... 7:00 AM–4:00 PM Wednesday ...... 7:00 AM–4:00 PM • If you see a demonstration or protest beginning, please contact any member of the SOT Annual Thursday ...... 7:00 AM–11:30 AM Meeting staff and they will initiate SOT response. If you see actions that appear threatening, notify the Speaker Ready Room nearest security officer. The Speaker Ready Room will be located in the SOT • Do not engage, defend either side, or subdue person(s) Headquarters Office (Room 14A) and is available during in any type of disturbance. Demonstrators are usually the SOT Headquarters Office hours listed above. trying to attract media attention. Don’t help them! • SOT representatives will respond to media inquires. Do not participate in interviews or other media responses. 30 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information (Continued)
Sponsorship Taxi Service GENERAL INFO The Society would like to invite your organization to be Taxi Fares from the San Diego International Airport to a proud sponsor of the Annual Meeting. SOT appreciates downtown are approximately $8–$10 one-way. the generous contributions of sponsors that make the Five can ride for the price of one! Taxicab stands are SOT Annual Meeting possible. Sponsor names are promi- located at the airport, most hotels, attractions, and shop- TM nently displayed on the Annual Meeting and ToxExpo ping centers. Your fare will be displayed on the meter and Web sites, as well as in print materials that are distributed will include a flag drop charge plus a per-mile and/or a before and during the Annual Meeting. Sponsorship is per-hour charge. All cabs leaving the airport charge the also recognized through signage displayed around the same rate. Rates for all other cab trips may vary from Convention Center during the Annual Meeting. company to company. There are five levels of sponsorship available: Diamond (over $10,000), Platinum ($5,000–$9,999), Gold ($2,500– Car Rental $4,999), Silver ($1,000–$2,499) and Contributor ($500– $999). You will find a complete menu of sponsorships Avis is the official car rental company for the SOT Annual at www.toxicology.org. Other promotional opportuni- Meeting and special low rates have been established. ties can be reviewed at www.ToxExpo.com. Special group rates are good one week before and after the event, so you can take in the sights and explore the For detailed information about SOT sponsor and promo- surroundings at your own pace. The Avis Car Rental tional opportunities, please contact Libby Jones at SOT Group Meetings & Group Sales Desk is staffed by helpful, Headquarters: (703) 438–3115 or E-mail: libby@toxicology. friendly representatives who are specially trained experts org. at handling all your car rental needs. Call Avis directly at (800) 331–1600 to reserve your car. Be sure to mention Transportation your Avis Worldwide Discount Number (AWD) T534999. San Diego offers many modes of transportation for travel Amtrak Train to and from and around the city. Full transportation information can be found at www.toxicology.org. Amtrak provides rail travel to and from San Diego with 11 round-trips per day to Los Angeles, continuing to Airport Transportation Santa Barbara and San Luis Obispo. The Santa Fe Depot (Amtrak) is located in the heart of downtown San Diego, Shuttles and taxis are the best mode of transportation to within walking distance of the San Diego Convention and from the San Diego International Airport. Center, Maritime Museum, Contemporary Art Museum, Children’s Museum, Harbor Excursion cruises, Seaport Shuttle Service Village, Horton Plaza, and the San Diego Concourse. Whether you are traveling to San Diego by rail or taking Cloud 9 Shuttle, San Diego International Airport’s shuttle a short trip between San Diego’s three picturesque coast- service, offers on-line reservations to and from the Airport. line stations (Old Town, Downtown, and San Diego Zoo), SOT attendees will receive a discount fare of $6 one-way Amtrak offers daily service. For schedules and fares, call (shared van service) for 1 passenger from the airport (800) USA-RAIL or visit www.amtrak.com. to all official SOT hotels when they make their shuttle reservations using the Cloud 9 Shuttle on-line reserva- tion system. To make your reservation, visit the Cloud 9 Bus and Trolley Shuttle Web site at www.cloud9shuttle.com or call San Diego County provides convenient transportation to (800) 974–8885 and identify yourself as being with the and from the airport, all shopping centers, attractions, SOT Annual Meeting to receive a discount. Cloud 9 Shuttle beaches, hotels, and Mexico via the Metropolitan Transit also offers charter service including sedans, limousines, System, public transportation, MTS buses, trolleys, and and extended passenger vans. coasters.
Bus schedules differ, but most hotels and attractions have service every 15 to 20 minutes. The San Diego Trolley runs every 15 minutes throughout most of the day and up-to-date information at www.toxicology.org 31 th GENERAL INFO GENERAL 45 Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo General Information (Continued) every 30 minutes in the evening. The North County Coaster runs 43 miles along the coast with station stops in The Toxicologist/Itinerary Planner downtown San Diego, Old Town, Solana Beach, Encinitas, (Print and CD-ROM) Carlsbad, and Oceanside. You can also get a free trolley transfer that will take you to Tijuana. All MTS buses, trol- All Annual Meeting registrants receive a copy of this leys and coasters are equipped with wheelchair lifts. For Program and The Toxicologist on CD-ROM, a special issue schedule and fare information contact the Metropolitan of Toxicological Sciences that includes all meeting abstracts. Transit System at (619) 233–3004 or visit their Web site at Special software on the CD, the Itinerary Planner, allows www.sdcommute.com. the meeting attendee to search the meeting abstracts and develop a personalized schedule for the meeting. 1. SOT members in the U.S. and Canada will receive Tour Information the Program and The Toxicologist on CD-ROM (with For tour information, visit the Tour Desk located in the Itinerary Planner) prior to the meeting, as will U.S. Registration area. and Canadian non-members who pre-register by January 9, 2006. A printed version of The Toxicologist Tour Desk hours: will be available on-site in the registration area for a fee Saturday, March 4 ...... 4:00 PM–7:00 PM of $20. Registrants may reserve a copy by signing up on Sunday, March 5 ...... 7:00 AM–5:00 PM the Registration form or may purchase a copy on-site, while supplies last. Monday, March 6 ...... 7:00 AM–5:00 PM Tuesday, March 7 ...... 8:00 AM–4:00 PM 2. Non-member registrants in the U.S. who register after Wednesday, March 8 ...... 8:00 AM–4:00 PM January 9 will receive the printed Program and The Toxicologist on CD-ROM (with Itinerary Planner) at the Thursday, March 9 ...... 8:00 AM–11:30 AM registration area on-site. Tour desk hours are subject to change. 3. The Annual Meeting Itinerary Planner will be available If you are interested in signing up in advance for tours, on the SOT Web site January–March. please visit the Event Team Web site at www.eventteam. com/sottours.html. The deadline date is February 14, 4. There will be computer kiosks available in the Exhibit 2006. All cancellations must be received by Tuesday, Hall (see map on page 23) to search The Toxicologist February 14, 2006, in writing, faxed to (619) 785–5822, on CD-ROM (with Itinerary Planner) at the Annual or e-mailed to [email protected]. There will be no Meeting. cancellations on-site. 5. International members who do not attend the Annual Meeting may contact the Headquarters office to request Tour buses will be departing from the Hall A Main a copy of the printed 2006 Program and The Toxicologist Entrance Lobby of the San Diego Convention Center. on CD-ROM. The materials will be mailed following the Annual Meeting.
Tour Tickets NOTE: Please bring your copy of the Program with you to the Tickets can be picked up on-site at the Tour Desk and will meeting. not be mailed in advance. Weather San Diego’s sun-sational climate makes it the ultimate year-round destination. In March, the average daytime temperature is a pleasant 66°F. The average nighttime temperature is 52°F. The average annual rainfall is less than 10 inches. A jacket or sweater is recommended.
32 SOT's 45th Annual Meeting up-to-date information at www.toxicology.org 33 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Career Resource and Development Services The Career Resource and Development (CRAD) Services e-mail message created from within the system. You include an on-line Job Bank, special Job Bank activities at may also contact these companies or candidates directly the SOT Annual Meeting, career development seminars by phone or fax. and resources, and employer ads in SOT’s newsletter, the Communiqué, which reaches the entire SOT membership CRAD Services can facilitate interviews at the SOT Annual Meeting. Employers and candidates can schedule
CAREER SERVICES CAREER and beyond. appointments, both in the CRAD interview rooms at the TM CRAD Job Bank Services Marriott Hotel and Marina or in the ToxExpo . The Society’s on-line CRAD Job Bank makes it easy for candi- How CRAD Job Bank Works dates and employers alike to access this year-round service anytime, anyplace from the SOT Web site at www.toxicology. The CRAD Web site is accessed through the SOT Home org. This forum links job candidates with employment posi- Page at www.toxicology.org. Simply select “Career tions in toxicology and related biological sciences. Resource and Development Services” from the Homepage, then select “Career Resources” from the drop-down • Candidates can gain access to a variety of positions that menu and you will be directed to the CRAD Job Bank. will be suited to their experience, areas of expertise, and To register, you have the option of paying by credit card desired geographical location. By posting resumes in on-line or faxing in your credit card information. (See fee this readily accessible Job Bank, employers can review schedule below). resumes and determine an appropriate match for the positions available. SOT Student Members can use Once you have completed the registration and submitted this service at no charge. SOT Student Members who a payment, you may complete either the employer or register for the Job Bank before the Annual Meeting candidate profile form. will not be charged the $20 on-site registration fee. • Your job description or candidate profile is then added • Employers from corporate, academic, and nonprofit to the database and remains active for six months. organizations can attract potential candidates in a • During the six-month period, you may update your targeted and cost-effective manner through this CRAD registration information, browse the jobs listed service. By having access to detailed candidate resumes, or candidate pool, conduct searches for a job or employers can determine the right match for a specific candidate that fits a certain profile, search for a part- or position and expedite the recruitment process. SOT full-time position or terminate your registration. Affiliates are entitled to one complimentary posting. You may also enter the system anonymously and browse • Registrations are continuously processed and valid for the information within the database. Some employers six months so there is fresh information regarding can- and candidates prefer to maintain their anonymity and didates and employment positions on an ongoing basis. the system provides this option. However, employers will • Once you have located a position or candidate of interest not be able to search for candidates in this category. from the database, communication can be made via an FEE SCHEDULE: Candidate Registration Employer Registration On-Site Position On-Site Registration Registration Registration Intro** Registration *The assisted fees Fee Fee Fee Positions Fee SOT Member apply to those Assisted* 60.00 60.00 SOT Corporate Associate companies or Non-Assisted 30.00 30.00 Assisted* 225.00 50.00 400.00 individuals who request that CRAD Non-Assisted 175.00 25.00 225.00 Non-Member Representatives input Assisted* 120.00 180.00 Corporation information or perform Non-Assisted 80.00 90.00 searches. Assisted* 450.00 50.00 675.00 Student Non-Assisted 350.00 50.00 525.00 **The Introductory Assisted* 40.00 40.00 Positions Fee applies Non-Assisted No Fee 20.00 Academic/Nonprofit to each position added Assisted* 200.00 50.00 300.00 within 7 days of Non-Assisted 100.00 50.00 150.00 Registration.
34 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Career Resource and Development Services Two weeks before your six month expiration date, the opportunity for personal contact. You are not required system will send you an e-mail message notifying you that to register for the Annual Meeting in order to utilize the your information will soon be purged. At that time, you CRAD Job Bank Center. If you are a candidate attending can renew for another six months. All users are encour- the Annual Meeting, you are encouraged to bring multiple aged to complete our on-line customer satisfaction survey copies of your personal resume for interested interviewers. after using the Job Bank. Your feedback helps us under- stand how to improve this system. CRAD Job Bank Center Locations are as follows at the Marriott Hotel & Marina: 2006 Annual Meeting CRAD Job Bank Center CRAD Interview Rooms ...... Pacific All users with current registrations at the time of the CRAD Message Center ...... Solano SOT Annual Meeting can use this service. Although pre- CRAD Job Posting Room ...... Point Loma registration is encouraged, registrations for the CRAD Job CRAD Registration Office ...... Leucadia Bank will be accepted at the meeting. Through the CRAD There are additional interview facilities in the San Diego Job Bank Center and services described below: Convention Center Exhibit Hall (see map on page 23). CAREER SERVICES • You can register as an employer or candidate, Hours of operation: • You can search the Job Bank database, Sunday (Registration Only) ...... 10:00 AM–3:30 PM • You can schedule interviews, Monday–Wednesday • You can send/retrieve messages electronically, and (All Services Available) ...... 8:00 AM–4:00 PM Thursday (Message Center • You can post hard copy messages. Bulletin Board Only) ...... 8:00 AM–12:00 NOON To maximize your time and the benefits of these services, For further information, contact: job and candidate searches should be conducted before you arrive at the Annual Meeting. Employers and candidates will Tierre Miller have access to computers, but computer use will be restricted SOT Career Services to registration or to short searches for new information. Tel: (703) 438-3115 Fax: (703) 438-3113 New electronic innovations this year will allow greater E-mail: [email protected] access to the CRAD Job Bank and messaging services. www.toxicology.org • Candidates can log onto the Job Bank using one of the terminals in the SOT ToxExpoTM Internet Café, or their Employer Ads in SOT Communiqué own personal computer. The Society’s newsletter, the Communiqué, is published • Additionally SOT members, CRAD Job Bank registrants four times annually. It includes career opportunity adver- and Annual Meeting attendees will have access to the tisements for employers from corporate, academic and Annual Meeting Message Center through a direct link from nonprofit organizations wishing to reach the entire SOT the SOT Web site using computers at the Message Center, membership and beyond. For more information, contact in Hall B, or any computer with an Internet connection. [email protected]. To ensure privacy for candidates, the CRAD Job Bank Center CRAD Seminars Series is located away from the scientific sessions. It is up to the registrants of the CRAD Job Bank to exercise the confiden- The CRAD Committee provides other resources for career tiality options that are offered. SOT is not responsible for development of toxicologists, including seminars and the release of any information contained in the CRAD Job web-based resources. To help with career development, Bank database. Be advised that all career service activities at plan on attending this year’s CRAD Seminars, including the SOT Annual Meeting will be carried out via the CRAD the following. Job Bank Center. Only employers who are registered on the • “Life After Your Post-Doc: Advice on Finding and CRAD Job Bank will be allowed to advertise positions. Landing a Job,” Monday, March 6, 2006, 4:30 PM– 6:00 PM, San Diego Convention Center, Room 2. The CRAD Message Center facilitates contact between candi- dates and employers and also offers interview areas at the • “SOT Grantsmanship Forum—Sources for Funding meeting. Neither employers nor candidates need be present Support,” Wednesday, March 8, 2006, 4:30 PM–6:00 PM, at the meeting; however, both are encouraged to use this San Diego Convention Center, Room 6E. up-to-date information at www.toxicology.org 35 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Social Events Awards Specialty Section & Ceremony Special Interest Group Sunday, March 5, 5:15 PM–6:30 PM Receptions San Diego Convention Center Monday, March 6 through Room 6C Wednesday, March 8, Join us as SOT honors our prestigious 12:00 NOON–1:30 PM and award winners at the SOT Awards 6:00 PM–7:30 PM Ceremony. Please refer to pages 37–42 San Diego Convention Center to learn more about the 2006 winners Each of the SOT Specialty Sections and the SOT Web site for complete and Special Interest Groups (SIG) will details and the nominating forms for Student/Post-Doctoral hold a meeting/reception during the next year. Fellow Mixer 2006 SOT Annual Meeting. All current and prospective SOT Specialty Section Sunday, March 5, 7:30 PM–8:30 PM Welcoming and SIG members are encouraged San Diego Convention Center to attend. Please check the Event Reception Room 33 Calendar beginning on page 2 for a Sunday, March 5, 6:30 PM–7:30 PM All students and post-docs are invited listing of meeting and reception times. San Diego Convention Center
SOCIAL EVENTS SOCIAL to attend this reception. Refreshments Sails Pavilion SOCIAL EVENTS SOCIAL will be provided by SOT and sponsors. Regional Chapter Start the 45th Anniversary Celebration, A cash bar will also be available. by attending the Welcoming Reception Ticket and meeting badge are required. Receptions following the Awards Ceremony. Monday, March 6 through Wednesday, The Welcoming Reception is a great Post-Doctoral Assembly March 8, Various Times opportunity to renew old friendships Marriott Hotel & Marina and to make new acquaintances. Please Event Many of the SOT Regional Chapters join the Society in this kick off of the Sunday, March 5, 8:00 PM–9:00 PM meet during the SOT Annual Meeting. 45th Annual Meeting. San Diego Convention Center A list of Regional Chapter reception Room 32 times and locations can be found in Join your post-doctoral colleagues, the Event Calendar beginning on after a visit to the Student/Post- page 2. Doctoral Fellow Mixer, at the Post-Doctoral Assembly Event. The 45th Post-Doctoral Assembly (PDA) is the formal group for these members. Take Anniversary this opportunity to network with each Raffle Contest other, discuss issues of importance Monday, March 6 through to you, plan activities, and get to know the new PDA Board members Wednesday, March 8, for 2006–2007. The featured speaker 12:00 NOON–1:30 PM is Jose Manautou, 2006 Achievement San Diego Convention Center 25-Year Award recipient. Light appetizers and a Exhibit Hall Member cash bar will be available. SOT 45th Anniversary Raffle Contest (or More) Reception will be held in the Exhibit Hall Monday, Tuesday, and Wednesday Sunday, March 5, 7:00 PM–8:00 PM between 12:00 NOON and 1:30 San Diego Convention Center PM. As part of the 45th Anniversary Room 4 Celebration, SOT will be giving away a Have you been a member of the Society total of $4500 over a three-day period! More details and contest rules are of Toxicology for 25 years (or more)? posted on the Annual Meeting If so, please join your colleagues Web site. in celebration of the Society’s 45th Anniversary and recognition of the scientists who established the Society. Invitation required. 36 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2006 Award Winners Dr. Jose Manautou is a highly deserving candidate for the 2006 SOT Achievement Award. His outstanding research Achievement Award and professional accomplishments place him among an elite few in the field of toxicology. The Awards Committee of the Society of Toxicology is honored to have selected Dr. Jose E. Manautou as the
recipient of the 2006 Achievement Award for significant contributions to Arnold J. Lehman Award the field of toxicology. Dr. Kate Mahaffey’s contributions to Dr. Manautou completed his under- our understanding of the risk posed by graduate training in pharmacy at the metals such as lead and methylmercury Jose E. University of Puerto Rico in 1985 date back over 30 years. Her early work and went on to carry out graduate Manautou demonstrated that the toxicity of lead work at Purdue University. His Ph.D. could be modulated through its inter- research under the direction of Dr. Gary Carlson focused actions with other essential metals such on the capacity of the lung to metabolize ethanol via as iron and calcium. She extended these oxidative, non-oxidative (esterification with free fatty efforts through both clinical studies acids) and conjugative pathways, such as glucuronidation Kathryn and use of the N-HANES data sets and and sulfation. After completing his graduate studies, he Mahaffey to corresponding risk assessments for accepted a post-doctoral position in biochemical toxi- lead that played an important role in cology at the University of Connecticut in the laboratory of the evolving regulatory decisions limiting the exposures Dr. Steven Cohen; he then joined the faculty at the of children to lead in the U.S. Similarly, Dr. Mahaffey University of Connecticut in the Department of has also contributed at several levels to the regulatory Pharmaceutical Sciences. For the past 10 years as an inde- process for limiting exposure of women of childbearing pendent academic scientist, Dr. Manautou’s research efforts age and children to methylmercury exposure through fish built on early findings from his post-doctoral work on consumption. She was one of the principal authors of the acetaminophen. His research interests focus on the study EPA’s Mercury Study Report to Congress that served as of mechanisms underlying the hepatoprotective actions the background for alerting the scientific and regulatory conferred by a class of compounds known as peroxisome communities to the health risks posed by methylmercury proliferators. He has published a number of seminal and for identifying subpopulations at highest risk from articles focused on pathways involved in cytoprotection such exposures. This award is granted in recognition and is currently evaluating transcriptional regulation of of her past and continuing contributions to regulatory hepatic transport proteins during liver injury. affairs and to risk assessment of chemical agents, partic- ularly on the health risks associated with exposures Dr. Manautou’s dedication to the training of young to the toxic metals lead and methylmercury. scientists is unmatched. His students speak proudly of his continued mentorship through daily problem solving, while allowing them the autonomy and flex- ibility needed for them to guide the path of their research projects. In addition to managing his research laboratory, AWARDS Dr. Manautou participates on a number of committees including the National Research Council Committee on Human Health Risks of Trichloroethylene and the European Commission Sixth Framework Programme on Food Quality and Safety on Risk Assessment of Non-Dioxin-Like Polychlorinated Biphenyls. Also worth mentioning is Dr. Manautou’s strong commitment to the Society of Toxicology. Dr. Manautou has been active on the Placement Committee, Mechanisms Specialty Section, and Minority Program where he has held a number of appointments. Most recently, Dr. Manautou served as SOT Councilor and was active as the Council Liaison to the Specialty Sections, Education Subcommittee for Minority Programs, the NIH Funding Task Force, and the Special Interest Group Task Force. up-to-date information at www.toxicology.org 37
45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2006 Award Winners (Continued) Jodi Flaws, University of Maryland Baltimore potential partners in industry and government. Under Ms. Mackta’s leadership, the NJABR sponsors an annual Project Title: Proposal to Develop a Micro-assay for “Thank You Research” month to celebrate the achievements Culturing Mouse Ovarian Surface Epithelium and Assessing of people and programs involved in biomedical research. DNA Adduct Formation This program includes a lesson plan that encourages Courtney E.W. Sulentic, Wright State University students to write thank you letters to researchers involved in an area of biomedical research that has affected them. Project Title: Modulation of the 3’ Immunoglobulin Heavy Ms. Mackta’s efforts have been instrumental in establishing Chair Regulatory Region, a Prospective In Vitro Screening the NJABR as a credible resource for providing informa- Tool for Identifying Potential Immunotoxicants tion for schools and public organizations on the important and integral role that animals play in biomedical research Xiaozhong Yu, University of Washington including toxicology. Her dedication to fostering awareness Project Title: Validation of an ECM-Overlay-Based 3-D in the community of the importance of animals in toxi- Sertoli Cell/Gonocyte Co-Cultures System as an In Vitro cology and other areas of biomedical research make her an Model for Assessment of Male Reproductive Toxicity excellent choice for the Contributions to Public Awareness of the Importance of Animals in Toxicology Research Award.
Contributions to Public Distinguished Lifetime Awareness of Animal Welfare Toxicology Scholar Award Award Dr. Sten G. Orrenious has made The Contributions to Public Awareness important contributions to the field of the Importance of Animals in of toxicology over the last 40 years. He Toxicology Research Award is received his Ph.D. in 1965 and his M.S. presented annually to an individual in 1967 from the Karolinska Institute (or organization) in recognition of in Stockholm, Sweden. He later was the contributions made to the public appointed Professor and Chairman of understanding of the role and impor- the Department of Forensic Medicine tance of experimental animals in at the Karolinska Insitute and also toxicological science. Sten G. became its Dean of Medicine. From 1988-1999, he served as Director Jayne Orrenius The 2006 Award winner, Ms. Jayne of the Institute of Environmental Mackta Mackta, is President of the New Jersey Medicine, and subsequently became Professor Emertius Association for Biomedical Research at the Karolinska Institute in 2004. During his tenure (NJABR), an organization that is a well known and widely he has contributed over 542 publications related to heard voice of reason in conveying the importance of cytochrome P-450, mechanisms of cytotoxicity, gluta- animals in toxicological research to the public. In her role thione and other cellular defense systems, oxidative stress, as President of this organization, Ms. Mackta is an untiring calcium signaling, and, most recently, regulation and
crusader. Not only is she active in providing public aware- mechanisms of cell death. The importance of his contri- AWARDS ness of this issue, she also participates in informing local butions is indicated by that fact that he is recognized as and national legislators of the need for government a Highly Cited Researcher by Thomson ISI. Moreover, recognition and appropriate legislation regarding the use he has received numerous professional honors, such as of animals in research. Ms. Mackta accomplishes her goal membership in the Royal Swedish Academy of Sciences, of educating the public about the importance of animals the Merit Award from EUROTOX, the MRC lectureship in research through diverse mechanisms. She established at the 41st Annual Meeting of the Society of Toxicology, a speakers bureau that links speakers with schools for the and the first European Cell Death Organization (ECDO) purpose of spreading the message of the value of animals Career Award for Excellence in Cell Death Research. This in all types of research. She developed a variety of programs SOT award is granted in recognition of his extensive and including the ASK program that supports teachers who continuing contributions in both research and mentor- believe in the importance of using animals in education, ship to the field of toxicology over the past four decades. the CLOUT program that educates elective officials to the Dr. Orrenius continues to be a major contributor both to importance of using animals in research, and roundtable our understanding of oxidative stress and calcium-mediated discussions that bring together academic scientists with cytotoxicity and to promotion of the field of toxicology. up-to-date information at www.toxicology.org 39 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2006 Award Winners (Continued) to SOT each year to participate in the national meeting and you are likely to discover that personal support from Education Award Dr. Schatz played a major role. We honor Dr. Schatz with the 2006 Education Award because of this personal dedi- The recipient of the 2006 Education cation and willingness to foster the development and Award is Dr. Robert A. Schatz, Associate career interest of undergraduate and graduate students in Professor of Toxicology and Director, toxicology. Toxicology Program, Bouve � College of Health Sciences, Northeastern University. January 2006 will be Dr. Schatz’s 25th anniversary for toxi- cology teaching at Northeastern Enhancement of Animal University! While Dr. Schatz has had a Welfare Robert long-standing interest in studying the Schatz influence of solvents on the regulation Dr. William S. Stokes, Director of of drug metabolizing enzymes in the the National Toxicology Program’s respiratory tract and consequent respiratory toxicity, his Interagency Center for the Evaluation greatest achievement has been the training of both under- of Alternative Toxicological Methods at graduate and graduate students in toxicology. the National Institute of Environmental Health Sciences, is the 2006 recipient Dr. Schatz began his career by receiving his B.S. in of the Enhancement of Animal Welfare Pharmacy from the Massachusetts College of Pharmacy Award. This award was instituted in (1966) and Masters in Pharmacology from Northeastern 2000 to honor a member of the Society University (1968). He received his Ph.D. in Pharmacology/ William S. of Toxicology whose scientific accom- Toxicology from the University of Rhode Island (1971) Stokes plishments have lead to a marked after which he was appointed as an NIH post-doctoral reduction in the use of experimental fellow at the Mental Health Research Institute, University animals for research. Dr. Stokes is responsible for directing of Michigan. From 1973-1981 he rose through the ranks the scientific evaluation of new chemical and product safety and reached the level of Senior Research Associate. In 1981, assessment methodologies that support improved protec- Dr. Schatz joined the Toxicology/Pharmacology Program tion of human health and improved animal welfare. He at Northeastern University. At Northeastern University, also administers the Interagency Coordinating Committee Dr. Schatz quickly assumed leadership positions. From on the Validation of Alternative Methods (ICCVAM), 1985-1988, he served as Acting Director of the Toxicology which reviews test methods of interagency interest and Program and was then appointed Director. He also served coordinates related validation, regulatory acceptance, and as Acting Director, Biomedical Sciences (1988-1990) and national and international harmonization issues within then Director of the Pharmaceutical Sciences Graduate the Federal government. Dr. Stokes is a Captain in the
AWARDS Program (1999-present). Dr. Schatz has also held numerous Commissioned Corps of the U.S. Public Health Service positions in the Society of Toxicology including, most (USPHS) and the Chief Veterinary Officer for the USPHS. recently, a member of the Animals in Research Committee In this role, he is responsible for providing leadership and (1998-2002) and Vice President of the Northeast Regional coordination of Public Health Service veterinary profes- Chapter of the Society of Toxicology (1998-1999). sional affairs for the Office of the Surgeon General and the Northeastern University has one of the few undergrad- Department of Health and Human Services. Dr. Stokes is a uate toxicology degree programs in the United States. recipient of the NIH Director’s Award and the Russell and This program has been very successful over the years in Burch Recognition Award from the Humane Society of the producing undergraduate students, numbering in the United States. Dr. Stokes also served as a Council member 100s, who have assumed leadership positions in academia, for the Institute for Laboratory Animal Research at the government and industry. Dr. Schatz has also trained 19 National Research Council, National Academy of Sciences doctoral students and has served on the thesis commit- from 1998-2004. The Society of Toxicology is pleased and tees of many others. The training of this large number of honored to recognize Dr. Stokes’ contributions to marked students from this small toxicology program, with limited reduction in the use of experimental animals for research. resources and space, is quite an accomplishment. The success of the Northeastern Toxicology program at both the undergraduate and graduate levels has been and continues to be completely dependent on Dr. Schatz’s continuous perseverance and, often, personal financial support. Ask any Northeastern University graduate how they traveled
40 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2006 Award Winners (Continued)
Merit Award Student Awards: Dr. A. Wallace Hayes has made significant contributions to the field of toxicology through his research Colgate Palmolive—SOT accomplishments, his mentorship of Awards for Student Research young scientists, his dedication to the associated societies and his textbook Training in Alternative contributions. Through his tenure in both corporate environments and Methods academic positions, he has been a Mary Hassani, University of Montana A. Wallace contributing author to over 180 peer- Hayes reviewed scientific reports and has Project Title: NAP(P)H:Quinone Oxidoreductase 1 (NQ01)- contributed to the publication of Directed Lavendamycin Antitumor Agent Development via nine reference books, including Principles and Methods of Molecular Modeling Toxicology, which serves as an indispensable guide not
only for those involved in risk assessment but for basic Prajakta Palkar, University of Louisiana Monroe scientists, clinicians and others. He has given generously of his time to the Society of Toxicology in roles on many Project Title: Proteomic Analysis to Elucidate the Mechanism different committees (Program, Technical, Animals in involved in Resiliency of Human RBC’s and New RBC’s from Research, Membership and Education) and served on its Primed Rats to BE is Due to Over-Expression of Endogenous Council. In addition, he has served in numerous edito- Inhibitors of Hydrolytic Enzymes. rial capacities for journals, including Editor of Toxicology and Applied Pharmacology. Dr. Hayes is currently editor of Cutaneous and Ocular Toxicology and editor for the Americas of Human and Experimental Toxicology. He has served on the board of Directors, and as Vice-President and President, of Pfizer Undergraduate Student the Academy of Toxicological Scences. His dedication to Travel Award education and mentoring is exemplified by his role in the establishment of the Leon Goldberg Memorial Post- Shawntay Chaney, University of Houston Doctoral Fellowship Program for Toxicology at Duke Theresa M. Eagle, Michigan State University University. Dr. Hayes has been active as a Board Member Natalie Malek, Texas A&M University and Officer of the Toxicology Education Foundation. He has served as a delegate to International Union of Adeliada Segarra, University of Puerto Rico Cayey Toxicology (IUTOX) and on several IUTOX commissions. Ryan Vaughan, University of Connecticut Storrs Dr. Hayes currently is the Secretary-General of IUTOX. Dr. Hayes has served on committees and expert panels for the National Academy of Sciences, the National Institutions of Health, the Environmental Protection
Agency and the Department of Defense as well as on AWARDS several international expert panels. Dr. Hayes is a diplomat of the American Board of Toxicology, the American Board The 2006 Novartis Graduate of Forensic Medicine and the American Board of Forensic Fellowship Examiners. He is a Fellow of the Academy of Toxicological recipient will be announced at the Sciences, the Institute of Biology (UK) and the American Annual Meeting. College of Forensic Examiners. Dr. Hayes is a registered toxicologist in the European Union (ERT). Dr. Hayes is currently at Harvard School of Public Health. For his past and continuing contributions, Dr. A. Wallace Hayes is highly deserving of the Merit Award.
up-to-date information at www.toxicology.org 41 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2005 Student Award Winners
These scientists were selected for Fellowships at the 2005 SOT Annual Meeting. Visit their presentations at this Meeting to see their outstanding work from their 2005–2006 Fellowship year.
Colgate-Palmolive Post-Doctoral Fellowship in In Vitro Toxicology Francis Tukov, Michigan State University
2006 Abstract: 1718
Title: Kupffer Cell/Hepatocyte Co-Culture as a Model to Assess Xenobiotic- Inflammation Interactions
Francis Tukov
Novartis Graduate Fellowship Andrea W. Wong, University of Toronto 2006 Abstract: 1435
Title: The Role of Oxidative DNA Damage and Repair in Methamphetamine- Initiated Neurodevelopmental Deficits
Andrea W. Wong AWARDS
Visit the SOT Web site for upcoming award details and deadlines at… www.toxicology.org
42 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index Continuing Education Courses General Scientific Sessions All courses will be held on Sunday, March 5, 2006, at the San (Listed by type, then date and time.) Diego Convention Center. Please check the signage in the registration area for room assignments. Note: Your course Monday materials will be available in the room immediately prior to the course (they will not be available at the Registration Symposia area). If you have your course ticket, go directly to the Date/Time Topic/Abstract # Room Page assigned course room. If you have not received your course Monday Lipidomics of Cell Death 6E 60 ticket or have not registered, please go to the Registration 9:30 AM #12–16 area on Saturday afternoon/evening or on Sunday Monday Regulation of Phase II 8 60 morning. If you have misplaced your ticket, please go to the 9:30 AM Xenobiotic Metabolizing Continuing Education Booth, Upper Level, at the San Diego Enzymes: Implications Convention Center on Sunday. The booth will be open from for Health and Disease #17–21
6:30 AM–5:15 PM. Course descriptions are on pages 49–55. Registration for the Annual Meeting is required for CE Monday Risk Assessment Implications 5B 61 attendees. 9:30 AM of Direct Nose–to–Brain Transport of Inhaled Xenobiotics #22–26 7:00 AM–7:45 AM, Sunrise Mini–Course: SR01. Use of Genome Databases for Toxicology Workshops 8:15 AM–12:00 NOON, Morning Courses Date/Time Topic/Abstract # Room Page AM02. Targeted Therapeutic Approach to Anti-Cancer Drug Monday Screening Methods for 5A 61 Development 9:30 AM Assessing Skin Toxicity of Nanomaterials #27–31 AM03. Reproductive Toxicity Testing: Study Designs, Evaluation, Interpretation, and Risk Assessment Monday Towards the Virtual Human: 2 62 9:30 AM Adding More Physiological AM04. Predictive Power of Novel Technologies (Cells to Detail to Biologically Based ‘Omics’): Promises, Pitfalls, and Potential Applications Models #32–36 AM05. Comparative Endocrine Toxicology Platform Sessions AM06. Essentials of Metal Toxicology Date/Time Topic/Abstract # Room Page AM07. Practical Strategies for Evaluation of Monday Alternative Models for 15A 62 Immunosuppression in Pharmaceutical Development 9:30 AM Assessment of Toxicity #37–45 1:15 PM–5:00 PM, Afternoon Courses Monday Frontiers of Neurotoxicology: 7B 63 PM08. Targeted Therapeutic Approach to Anti-Cancer Drug 9:30 AM Extrapolation and Human Development Health #46–51 Monday Gene Expression Changes in 1A 63 PM09. Reproductive Toxicity Testing: Study Designs, 9:30 AM Carcinogenesis #52–59 Evaluation, Interpretation, and Risk Assessment Monday Modulation of Carcinogenesis 7A 64 PM10. Functional Analysis of Gene and Protein Expression: 9:30 AM by Naturally Occurring From Experimental Design to Data Analysis Polyphenolic Compounds PM11. Xenobiotic Transporters #60–67
PM12. Neuropathology for the Toxicologist
PM13. Assessing Airway Injury and Remodeling Induced by Inhaled Pollutants Using Magnetic Resonance Imaging, Microscopy, and Modeling
SESSION INDEX up-to-date information at www.toxicology.org 43 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index (Continued) Poster Sessions Workshop *Attended 9:30 AM–11:00 AM; otherwise attended 10:30 AM–12:00 NOON. Date/Time Topic/Abstract # Room Page Date/Time Topic/Abstract # Room Page Monday Advances in Asbestos 15A 87 1:30 PM Toxicology and Exposure Monday * Chemical–Biological Weapons I Exhibit Hall 65 Assessment #347–352 9:30 AM #68–81 Monday Persistent Organic Pollutants Exhibit Hall 66 Platform Sessions 9:30 AM #82–108 Date/Time Topic/Abstract # Room Page Monday * Children’s Health and Juvenile Exhibit Hall 68 Monday Ah Receptor II #353–361 7A 88 9:30 AM Animal Toxicity #109–127 1:30 PM Monday Developmental Toxicity in Exhibit Hall 69 Monday Developmental Toxicity 5A 88 9:30 AM In Vivo and In Vitro Systems 1:30 PM In Vivo and In Vitro #128–156 Investigations #362–370 Monday * Biomarkers #157–193 Exhibit Hall 71 Monday Hypersensitivity #371–379 5B 89 9:30 AM 1:30 PM Monday Peroxisome Proliferators/PPAR Exhibit Hall 74 Monday Risk Assessment—Regulatory/ 1B 90 9:30 AM #194–207 1:30 PM Policy #380–388 Monday * Ah Receptor I #208–228 Exhibit Hall 75 9:30 AM Poster Sessions Monday Responses to Particulates Exhibit Hall 77 *Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM. 9:30 AM #229–244 Date/Time Topic/Abstract # Room Page Monday * Immunomodulation #245–288 Exhibit Hall 78 9:30 AM Monday * Female Reproduction Exhibit Hall 90 1:30 PM #389–406 Monday Cardiovascular System: Exhibit Hall 81 9:30 AM Valvular and Vascular Injury Monday Arsenic Toxicology #407–445 Exhibit Hall 92 #289–310 1:30 PM Monday * Kidney #446–477 Exhibit Hall 95 Symposia 1:30 PM Date/time Topic/Abstract # Room Page Monday Oxidative Injury Mechanisms Exhibit Hall 97 Monday Advancing Toxicology by 6F 83 1:30 PM #478–513 1:30 PM Improving Linkage of Monday * Genotoxicity/DNA Repair Exhibit Hall 99 Traditional Toxicity and 1:30 PM #514–560 Pathology Endpoints With Toxicogenomics #311–316 Monday Toxicokinetics/ Exhibit Hall 102 1:30 PM Pharmacokinetics #561–605 Monday The Biological Matrix of In 7B 84 1:30 PM Vitro Systems and Their Use in Monday * Safety Evaluation— Exhibit Hall 105 Toxicology #317–322 1:30 PM Pharmaceuticals 1 (Neuro, Monday Indirect Mechanisms of 6E 84 Cardiovascular, Endocrine/ 1:30 PM Toxicity: Advancing Our Metabolic) #606–634 Understanding of Monday Respiratory Tract Injury: Exhibit Hall 107 Neuroendocrine–Immune 1:30 PM Cellular Mechanisms Interactions #323–327 #635–648 Monday Mode of Action Associated 2 85 Monday * Cardiovascular System: ECG Exhibit Hall 108 1:30 PM with Induction of 1:30 PM and hERG #649–667 Endothelial Cell Tumors— Hemangiosarcoma #328–334 Monday Metabolism Toxicity and
SESSION INDEX SESSION 1:30 PM Polymorphisms #668–704 Exhibit Hall 110 Monday New Concepts in the 6B 86 1:30 PM Neurotoxicology of Lead #335–340 Monday New Insights into Mechanisms 8 86 1:30 PM of Cell Death and Survival #341–346
44 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index (Continued) Roundtable Date/Time Topic/Abstract # Room Page Date/Time Topic/Abstract # Room Page Tuesday Does the Methylation of 5A 120 9:00 AM Inorganic Arsenic Affect its Monday The Complexities of Air 7A 112 Toxicity and Mode(s) of Action: 4:30 PM Pollution Regulation: The A Critical Discussion #758–762 Need for an Integrated Research and Regulatory Perspective Tuesday New Food Ingredients Do Not 1B 120 #705–710 9:00 AM Need New Food Regulations #763–768 Sunset Sessions Tuesday Regulatory Application of the 7B 121 Date/Time Topic/Abstract # Room Page 9:00 AM Mouse LLNA: New Challenges and Opportunities #769–774 Monday Distance Learning in 6C 113 4:30 PM Toxicology: Effective Teaching Through Technology #711–716 Platform Sessions Date/Time Topic/Abstract # Room Page Monday Toxicology in the Courtroom: 6F 113 4:30 PM Establishing Causation—A Tuesday Ah Receptor III #775–783 6C 121 Roundtable Discussion 9:00 AM #717 Tuesday Biomarkers: Identification and 15A 122 9:00 AM Application #784–791 Tuesday Tuesday Genetic Polymorphisms 6F 123 9:00 AM #792–800 Roundtables Tuesday In Vitro and In Vivo Responses 7A 123 Date/Time Topic/Abstract # Room Page 9:00 AM to Smoke #801–807 Tuesday The Precautionary Principle— 2 115 7:30 AM Implications and Applications Poster Sessions #718–722 *Attended 9:00 AM–10:30 AM; otherwise attended 10:30 AM–12:00 NOON. Tuesday Research and Development of 7B 116 7:30 AM Child Specific Protection in Date/Time Topic/Abstract # Room Page California #723–729 Tuesday * Dermatotoxicity #808–847 Exhibit Hall 124 9:00 AM Symposia Tuesday Epidemiology/Exposure Exhibit Hall 127 Date/Time Topic/Abstract # Room Page 9:00 AM Assessment #848–878 Tuesday Development of Safety 2 117 Tuesday * Risk Assessment Methods— Exhibit Hall 129 9:00 AM Qualification Thresholds and 9:00 AM Regulatory/Policy #879–918 Their Use in Drug Product Evaluation #730–735 Tuesday Developmental Toxicity Exhibit Hall 131 9:00 AM Testing in Mammalian Systems Tuesday Risk Assessment and Regulatory 6E 118 #919–947 9:00 AM Implications of Convulsive Neurotoxicity #736–740 Tuesday * Carcinogenesis Mechanisms Exhibit Hall 134 9:00 AM #948–983 Tuesday Role of Mitochondria in Toxic 8 118 9:00 AM Oxidative Stress #741–745 Tuesday Bioinformatics #984–998 Exhibit Hall 136 9:00 AM Workshops Tuesday * Acetaminophen #999–1010 Exhibit Hall 137 Date/Time Topic/Abstract # Room Page 9:00 AM Tuesday Comprehensive Responses of 1A 119 Tuesday Kinase Signaling #1011–1022 Exhibit Hall 138 9:00 AM Lipids Classes to Toxicants and 9:00 AM Involvement in Diseases #746–751 Tuesday * Respiratory Tract Irritation, Exhibit Hall 139 9:00 AM Infection and Inflammatory Tuesday Discovery Toxicology: Injury #1023–1044 9:00 AM Strategies in the New 5B 119 Drug Discovery Paradigm Tuesday Inorganic Particles and Fumes Exhibit Hall 141 #752–757 9:00 AM #1045–1059 Tuesday * Ozone #1060–1070 Exhibit Hall 142 9:00 AM SESSION INDEX up-to-date information at www.toxicology.org 45 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index (Continued) Date/Time Topic/Abstract # Room Page Poster Sessions Tuesday Toxicogenomics #1071–1094 Exhibit Hall 143 *Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM. 9:00 AM Date/Time Topic/Abstract # Room Page Tuesday * Nervous System: Disease Exhibit Hall 144 9:00 AM Models #1095–1115 Tuesday * Pesticides #1202–1220 Exhibit Hall 156 1:30 PM Symposia Tuesday Hepatocarcinogenesis Exhibit Hall 158 1:30 PM #1221–1231 Date/Time Topic/Abstract # Room Page Tuesday * Multigeneration Reproductive Exhibit Hall 159 Tuesday Alternative Model Organisms 5B 148 1:30 PM Toxicity Evaluations 1:30 PM for the Analysis of #1232–1245 Developmental and Molecular Toxicology #1116–1121 Tuesday Biomonitoring #1246–1267 Exhibit Hall 160 1:30 PM Tuesday Role of the Kupffer Cell in 6C 149 1:30 PM Mediating Hepatic Toxicity Tuesday * Physiologically–Based Models: Exhibit Hall 162 and Carcinogenesis 1:30 PM Applications #1268–1280 #1122–1127 Tuesday Safety Assessment—Methods Exhibit Hall 163 Tuesday Using Structure–Based 8 149 1:30 PM and Models #1281–1320 1:30 PM Approaches for Hazard Identification and Risk Tuesday * Nuclear Receptors #1321–1341 Exhibit Hall 165 Assessment #1128–1133 1:30 PM Tuesday The War on Ozone in the 3rd 6F 150 Tuesday Gene Regulation I #1342–1360 Exhibit Hall 167 1:30 PM Millennium: Toxicology and 1:30 PM Health Effects Update Tuesday * Gene Regulation II #1361–1386 Exhibit Hall 168 #1134–1139 1:30 PM Tuesday Natural Products #1387–1424 Exhibit Hall 170 Workshops 1:30 PM Date/Time Topic/Abstract # Room Page Tuesday * Neurotoxicity: Developmental Exhibit Hall 173 Tuesday Dendritic Cells and Skin 6D 151 1:30 PM #1425–1461 1:30 PM Sensitization: Biological Roles and Uses in Hazard Tuesday Neurotoxicity: Pesticides Exhibit Hall 176 Identification #1140–1145 1:30 PM #1462–1491 Tuesday Genomics in Risk Assessment: 6B 151 1:30 PM Utility for the Characterization Wednesday of Mode of Action #1146–1150 Tuesday Potential Human Health Risk 2 152 Symposia 1:30 PM from Estrogenic Food and Date/Time Topic/Abstract # Room Page Consumer Product Additives: How Much is Real and How Wednesday Gene-Nutrient-Environment- 6B 179 Much is Hype? #1151–1156 9:00 AM Interactions as Risk Factors for Birth Defects: Fumonisin, Folate, Genetic Variation and Neural Platform Sessions Tube Defects #1492–1496 Date/Time Topic/Abstract # Room Page Wednesday Models and Mechanisms of 6F 180 Tuesday Apoptosis #1157–1165 1B 152 9:00 AM Occupational/Environmental 1:30 PM Asthma #1497–1502 Tuesday Endocrine Disruptors— 15A 153 Wednesday Obesity as a Modulator of 6C 180 1:30 PM Mechanisms #1166–1174 9:00 AM Chemical Toxicity #1503–1508
SESSION INDEX SESSION Tuesday Metals Toxicology I 7A 154 Wednesday The Role of MAP Kinases in 7B 181 1:30 PM #1175–1183 9:00 AM Metal Toxicity #1509–1514 Tuesday Oxidative Injury #1184–1192 7B 155 1:30 PM Tuesday Particulate Matter: Effects and 5A 155 1:30 PM Mechanisms #1193–1201
46 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index (Continued) Workshops Date/Time Topic/Abstract # Room Page Date/Time Topic/Abstract # Room Page Wednesday Neurotoxicity: Metals— Exhibit Hall 201 9:00 AM General #1768–1802 Wednesday Advanced Technologies and 15A 181 9:00 AM Approaches for Quantitative Wednesday * P450 Expression and Exhibit Hall 203 Biological Monitoring and 9:00 AM Regulation #1803–1835 Modeling for Chemical Exposures #1515–1520 Symposia Wednesday Thermoregulation and Its 6E 182 Date/Time Topic/Abstract # Room Page 9:00 AM Influence on Toxicity Assessment #1521–1526 Wednesday The Bases for Inter–Individual 6E 207 1:30 PM Differences in Susceptibility to Platform Sessions Allergic Disease #1836–1841 Date/Time Topic/Abstract # Room Page Wednesday Determinants of Manganese 6A 207 1:30 PM Neurotoxicity: From Worms to Wednesday Cardiovascular Safety 2 183 Man #1842–1847 9:00 AM Assessment #1527–1535 Wednesday Mechanisms of Low Solubility 1B 208 Wednesday Dioxins, PCBs and PBDEs 1B 183 1:30 PM Particle-Induced Lung Tumors 9:00 AM #1536–1544 #1848–1853 Wednesday Male and Female Reproductive 8 184 Wednesday The Path for Assessing Human 6C 208 9:00 AM System #1545–1553 1:30 PM Relevance and Advancing New Safety Biomarkers for Drug Wednesday Nanoparticle–Induced Toxicity 5A 185 Induced Vascular Injury 9:00 AM #1554–1562 #1854–1859 Wednesday Role of Epigenetics in the Fetal 5A 209 Poster Sessions 1:30 PM Basis of Adult Disease *Attended 9:00 AM–10:30 AM; otherwise attended 10:30 AM–12:00 NOON. #1860–1864 Date/Time Topic/Abstract # Room Page Workshops Wednesday * Ecotoxicology #1563–1587 Exhibit Hall 186 9:00 AM Date/Time Topic/Abstract # Room Page Wednesday Alternative Models for Exhibit Hall 188 Wednesday Hormesis: A Challenge to the 8 210 9:00 AM Assessment of Ocular and 1:30 PM Linear Dose–Response Model, Dermal Toxicity #1588–1601 and its Implications in Risk Assessment, Regulatory Policy, Wednesday * Risk Assessment I #1602–1641 Exhibit Hall 189 and Biomedical Research 9:00 AM #1865–1870 Wednesday Carcinogenesis—Modulation Exhibit Hall 191 Wednesday Integrating Biomonitoring into 7A 210 9:00 AM #1642–1657 1:30 PM Epidemiology and Toxicology Research #1871–1875 Wednesday * Disease and Toxicity Exhibit Hall 192 9:00 AM Biomarkers #1658–1671 Platform Sessions Wednesday Safety Assessment— Exhibit Hall 193 Date/Time Topic/Abstract # Room Page 9:00 AM Pharmaceuticals 2 (Oncology, Anti–Inflammatory, Wednesday Biotransformation #1876–1884 7B 211 Anti–Infectives, Excipients, 1:30 PM Natural Products) #1672–1693 Wednesday Bioinformatics and Biological 15A 211 Wednesday * Inhalation Methods and Exhibit Hall 195 1:30 PM Modeling #1885–1892 9:00 AM Dosimetry #1694–1705 Wednesday Immunotoxicity #1893–1901 5B 212 Wednesday Liver I #1706–1717 Exhibit Hall 196 1:30 PM 9:00 AM Wednesday Predicting Compound 2 213 Wednesday * In Vitro Immunotoxicity Exhibit Hall 197 1:30 PM Toxicity #1902–1909 9:00 AM #1718–1736 Wednesday Methods in Immunotoxicity Exhibit Hall 198 9:00 AM #1737–1750 Wednesday * Neurotoxicity: Metals— Exhibit Hall 199 9:00 AM Manganese #1751–1767 SESSION INDEX up-to-date information at www.toxicology.org 47 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Scientific Session Index (Continued) Poster Sessions Symposia *Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM. Date/Time Topic/Abstract # Room Page Date/Time Topic/Abstract # Room Page Thursday Air Pollution: Vanguard 2 237 9:00 AM Toxicological Approaches Wednesday * Chemical–Biological Exhibit Hall 213 Considering Atmospheric 1:30 PM Weapons II #1910–1927 Aging #2210–2215 Wednesday Endocrine Disruptors Exhibit Hall 215 Thursday Application of Genomics to 8 238 1:30 PM #1928–1954 9:00 AM Evaluating Mechanisms of Genotoxicity and Wednesday * Alternatives to Mammalian Exhibit Hall 217 Carcinogenicity #2216–2221 1:30 PM Models #1955–1976 Thursday Idiosyncratic Hepatotoxicity: 6D 239 Wednesday Food Safety and Nutrition Exhibit Hall 218 9:00 AM Non–Clinical Predictive 1:30 PM #1977–2001 Toxicology for Liver Injury Wednesday * Cell Death/Apoptosis Exhibit Hall 220 Potential #2222–2226 1:30 PM #2002–2021 Thursday Metabonomics: Moving 5B 239 Wednesday CD Toxicity, Zinc, and Exhibit Hall 222 9:00 AM Beyond the Profile 1:30 PM Metallothionein #2022–2042 #2227–2231 Wednesday * Metals Toxicology II Exhibit Hall 223 Thursday Obesity: Developmental 7B 240 1:30 PM #2043–2082 9:00 AM Origins and Environmenal Influences #2232–2237 Wednesday Carcinogenesis Bioassay Exhibit Hall 226 1:30 PM #2083–2095 Workshops Wednesday * Male Reproductive Toxicity Exhibit Hall 227 Date/Time Topic/Abstract # Room Page 1:30 PM Evaluations #2096–2114 Thursday Immunotoxicity Evaluation 5A 240 Wednesday Computational Toxicology Exhibit Hall 229 9:00 AM by Immune Function Tests 1:30 PM #2115–2128 #2238–2242 Wednesday * Liver II #2129–2150 Exhibit Hall 230 Thursday Pharmaceuticals in the 7A 241 1:30 PM 9:00 AM Environment: Leveraging Wednesday Cardiovascular System: Exhibit Hall 231 Mammalian Data in 1:30 PM Cardiotoxicity #2151–2179 Determining Human Pharmaceutical Responses in Wednesday * Risk Assessment—Metals Exhibit Hall 233 Aquatic Vertebrates #2243–2248 1:30 PM #2180–2202 Poster Sessions Roundtables *Attended 9:00 AM–10:30 AM; otherwise attended 10:30 AM–12:00 NOON. Date/Time Topic/Abstract # Room Page Date/Time Topic/Abstract # Room Page Wednesday Food Safety and Security: 5A 235 4:30 PM Regulatory and Industry Thursday * Hypersensitivity: Mechanisms 6A 242 Safeguards #2203–2207 9:00 AM and Methods #2249–2283 Wednesday U.S. EPA’s 2005 Cancer 5B 235 Thursday Risk Assessment II #2284–2320 6A 244 4:30 PM Guidelines #2208 9:00 AM Thursday * Safety Evaluation— 6A 246 9:00 AM Non-Pharmaceutical Thursday #2321–2348 Historical Highlight Thursday Biomarkers: Methods & Tools 6A 248 Date/Time Topic/Abstract # Room Page 9:00 AM #2349–2364 Thursday * Physiologically–Based Models: 6A 249 SESSION INDEX SESSION Thursday Historical Highlight: 7B 237 8:00 AM Organophosphates from Nerve 9:00 AM Development and Evaluation Gas to Insecticide #2209 #2365–2383 Thursday Analytical Toxicology 6A 251 9:00 AM #2384–2391 Thursday * Liver III #2392–2410 6A 251 9:00 AM Thursday Nervous System: Mechanisms 6A 253 9:00 AM and Effects #2411–2442 48 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Continuing Education CE The Continuing Education Program offers a wide range of courses TARGETED THERAPEUTIC APPROACH TO ANTI-CANCER that cover state-of-the-art knowledge in toxicology, as well as new DRUG DEVELOPMENT developments in toxicology and related disciplines. Courses can be applied toward certifying and licensing board requirements and may AM 02 (REPEATS AS PM 08) ADVANCED also be used for recertification with the American Board of Toxi- cology (ABT). Both basic and advanced course topics are offered. Chairperson(s): Vijayapal Reddy, Eli Lilly & Company, Greenfield, IN and The basic course is intended to provide a broad overview of an area Myrtle A. Davis, Eli Lilly & Company, Greenfield, IN. or to assist individuals in learning new techniques or approaches. The advanced course is intended to be of interest to individuals with Endorsed by: previous knowledge of the subject or already working in the field. Comparative and Veterinary SS Regulatory and Safety Evaluation SS* Please Note: Each Continuing Education Course is offered in one of three time blocks: Sunrise (7:00 AM–7:45 AM), AM (8:15 AM–12:00 Over the past decade, a range of targeted anti-cancer drugs have been NOON) or PM (1:15 PM–5:00 PM). Registration for the Annual Meeting developed that are designed to interfere with one or more of the many is required. See signage in Lobby 6 Ballroom Foyer for room locations. molecular mechanisms that drive tumor growth. The molecularly-targeted approach to the development of these new anti-cancer drugs has created a *The Primary Specialty Section (SS) or Regional Chapter (RC) Endorser false impression that these newer drugs, unlike earlier cytotoxic anti-cancer drugs, will be non-toxic. Cytotoxic drugs are typically administered in USE OF GENOME DATABASES FOR TOXICOLOGY short courses of maximal doses (MTD). This is not necessarily appro- priate for targeted therapies, which can require long-term therapy and for which it is often difficult to determine the biologically most effective SUNRISE MINI-COURSE 1 BASIC dosage (BED). This course will focus on different aspects of regulatory, Chairperson(s): William B. Mattes, Gene Logic Inc., Gaithersburg, MD. pre-clicical, and clinical targeted anti-cancer drug development. The first speaker will focus on tumor cell biology and the respective cell signaling Endorsed by: pathways that hold promise for targeted anti-cancer therapy. The second Mechanisms SS speaker will present differences in pre-clinical development philosophy National Capital Area RC between cytotoxic and targeted anti-cancer drugs. The third speaker will discuss specific examples of pre-clinical development of targeted Molecular and genomic information is increasingly an important part of all biotherapeutics. The fourth speaker will discuss biomarkers as endpoints biological research including toxicology. While toxicologists often focus of clinical efficacy and safety assessment. The final speaker will focus on on data from microarray-based expression profiles, other molecular data, regulatory considerations of pre-clinical development of targeted therapies, including the organization and function of genes in the context of the cell, highlighting differences between cytotoxic and targeted therapies. This the physical genome and sequence, and the relationships between species advanced course in drug development is targeted to government, biotech- in terms of this organization, can provide important insights. Therefore nology and pharmaceutical toxicologists as well as general toxicologists facilities with public molecular biology databases and search tools are with an interest in cancer chemotherapy. essential to all toxicologists. Moreover, the recent availability of complete genomes, including the human, mouse and rat, has made genome-wide • Identification, Pharmacologic Expectations and Toxicological queries and comparative genomics readily accessible to all researchers Considerations for Targeted Therapies, Myrtle A. Davis, Eli Lilly and has the potential to revolutionize medical research and practice. The & Company, Greenfield, IN. largest public repository of biological sequence information is maintained • The Development of Cytotoxics to MTD and Targeted Drugs by the National Center for Biotechnology Information (NCBI) at the to BEDs: Is this the Correct Paradigm? Joseph E. Tomaszewski, National Library of Medicine. This course will describe the molecular National Cancer Institute, Rockville, MD. database resources, including sequences, structures and genomes, and the tools available through the WWW interface to the NCBI. The discussion • Pre-clinical Safety Evaluation of Anti-Cancer Biotherapeutics, will then focus on using these tools and databases as well as the special- Joseph Beyer, Toxicology & Pathology, Genetech, Inc., South San ized genomic resources. The Entrez and BLAST Web services will be Francisco, CA. demonstrated and how both can be used as a biological discovery system in • Targeted Efficacy and Targeted Toxicity: Are the Biomarkers the toxicology will be illustrated. This tutorial is intended as an overview and Same? Kerry L. Blanchard, Eli Lilly & Company, Greenfield, IN. introduction of NCBI genomic and molecular databases to toxicologists, but even experienced users will find it helpful. • Regulatory Considerations for Non-Clinical Development of Anti- Cancer Drugs, John K. Leighton, U.S. FDA, Rockville, MD. • Use of Genome Databases for Toxicology, Peter S. Cooper, NCBI User Services, National Library of Medicine, Bethesda, MD.
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, Christopher , Kok Wah Hew, Hew, , Kok Wah
, Barry S. McIntyre, Schering Plough Research 45th Annual Meeting and ToxExpo and Meeting Annual 45th , Rochelle W. Tyl, RTI International, Tyl, , Rochelle W. Research Triangle
Considerations Institute, Lafayette, NJ. Assessment Park, NC. Purdue Pharma Ardsley, NY. LP, J. Bowman,J. WIL Research Laboratories, LLC, Ashland, OH. Reproductive and Developmental Toxicology SS* Toxicology and Developmental Reproductive Risk Assessment SS Risk Regulatory and Safety Evaluation SS Evaluation Regulatory and Safety This course is intended to a for provide general scientists overview respon human reproduction. • Designs and General Study Testing: Toxicity Reproductive Ashland, OH. by: Endorsed AM 03 (REPEATS AS PM 09) AS PM AM 03 (REPEATS LLC, Laboratories, WIL Research Stump, Chairperson(s): Donald G. REPRODUCTIVE TOXICITY TESTING: STUDY DESIGNS, DESIGNS, STUDY TESTING: TOXICITY REPRODUCTIVE ASSESSMENT AND RISK INTERPRETATION, EVALUATION, sion. Individual lectures will discuss the anatomy and male physiology and of female the reproductive systems as well as endocrine regulation these of systems. Evaluation of toxicity endpoints to assess male and female reproductive function will also be discussedestrous cyclicity, includingspermatogenesis, sexual mating,behavior, parturition, fertility,reproduc tive hormone analysis, nesting and nursing behavior, reproductive weights organ and histopathology, and proper courseuse willof concludestatistical with analysis.discussions The to on reproductivesome toxicitycommon testing,issues interpretationrelated results of are ultimately used results,to assess potential risks andto human reproduction. how these In summary, this course will present the key information required for the design of reproductive toxicity studies and interpretation of guidance for use of the data for risk assessment of data and provide toxicity reproductive sible for the design, conductstudies. andThe monitoringcourse ofwill reproductiveconsiderations,focus on toxicity reproductivereproductive endpoints,biology,data in risk datastudyassessment. Reproductive toxicity studies interpretationdesignare among the most and complexuse and of challenging studies in the fieldassess multipleof toxicology. Theinterrelated studies endpoints of function. In order to maleproperly design, conduct and interpret these andstudies, a female reproductive fundamental knowledge of male and female reproductive system develop ment, anatomy, physiology, and endocrinology are required. This coursewill discuss the designs of reproductive studies for regulatory submis
• Endpoints Toxicity and Biology Male Reproduction: Continuing Education Education Continuing • Endpoints Toxicity and Biology Reproduction: Female • and Risk Data Interpretation Testing: Toxicity Reproductive
CE 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Continuing Education (Continued) CE COMPARATIVE ENDOCRINE TOXICOLOGY ESSENTIALS OF METAL TOXICOLOGY
AM 05 BASIC AM 06 BASIC
Chairperson(s): Stephen B. Hooser, Purdue University, West Lafayette, IN Chairperson(s): Wei Zheng, Purdue University, West Lafayette, IN and and Charles C. Capen, The Ohio State University, Columbus, OH. Michael P. Waalkes, NIEHS, Research Triangle Park, NC.
Endorsed by: Endorsed by: Comparative and Veterinary SS* Mechanisms SS Reproductive and Developmental Toxicology SS Metals SS* Toxicologic & Exploratory Pathology SS Neurotoxicology SS Risk Assessment SS Hormones secreted by cells of the endocrine system have diverse effects throughout the body. Exposure to xenobiotic compounds can result in Metals are ubiquitously present in environment, essential to human health, profound changes to the endocrine organs and/or their target cells. Signifi- and yet toxic upon overexposure. They are neither synthesized by living cant species differences exist in the structure and function of endocrine and matter nor destroyed by human endeavour. Metals play a significant role in reproductive organs making interpretation of test results and extrapola- many human diseases. Unique physical, chemical and biological properties tion from animal models to humans more challenging. In addition to the allow metals to persist in the body, cause long-lasting effects, and yet leave numerous anatomical and physiological differences, there are also species few choices for therapeutic intervention. A fundamental question remains, variations in metabolism and response to toxicants. It is the goal of these namely what makes metals toxic in promoting carcinogenesis, neurotox- presentations to give an overview of the structure, function, regulation, and icity, reproductive, liver and kidney injuries, or generalized metabolic toxic responses of selected endocrine and reproductive organs. In addi- disease? This basic course is intended to address the essentials in metal tion, the speakers will discuss the hormonal assays and other mechanistic toxicology by providing cutting-edge knowledge on the concepts, theories, approaches necessary to make species comparisons, and to extrapolate clinical outcome, and research methodologies in metal toxicology. The the findings from animals to humans. Each presentation will briefly first lecture will highlight the clinical symptoms of metal-induced human describe important species differences with regard to anatomy, endocrine diseases, common routes of exposure, and therapeutic intervention. Two physiology, and response to different classes of xenobiotic chemicals by subsequent lectures will address metal pharmacokinetics and the general selected endocrine and reproductive organs such as the thyroid (follicular mechanisms of metal-induced cell death, specifically apoptosis. The final cells), ovary, and testis (Leydig cells). One presentation will focus on the lecture will discuss animal models, based on either symptomatic outcomes principles and pitfalls of hormonal measurements in laboratory animals or biochemical consequences, for studying metal toxicities. Speakers will considering advantages/disadvantages of different methods, species speci- address these essentials by providing details specific to “hot” metals, such ficity of certain assays, most appropriate sampling times, and other useful as arsenic, mercury, manganese, lead, and uranium. The course will serve items to consider in future protocol development. Following completion of as an introduction to those who desire an expanded knowledge on essen- this workshop, attendees should have a more complete understanding of tials of metals in human health and diseases, essentials of toxicological the comparative endocrinology and toxicology of selected endocrine and actions of metals, and essentials of research approaches in metal toxico- reproductive organs in laboratory animals. logical investigation. The course will also be of interest to others engaged in wider aspects of carcinogenesis, neurotoxicology, risk assessment, and • Comparative Endocrine Toxicology of the Thyroid Gland, Charles occupational health. C. Capen, The Ohio State University, Columbus, OH. • Metals in Human Diseases: Symptoms and Clinical Intervention, • Comparative Ovarian Toxicology, Jodi Flaws, University of Wei Zheng, Purdue University, West Lafayette, IN. Maryland, Baltimore, MD. • Distribution of Metals: Role of Metal Transporters and Selectivity • Comparative Endocrinology and Toxicology of Testicular Leydig of Disposition, Michael Aschner, Vanderbilt University, Nashville, Cells, Jon C. Cook, Pfizer, Inc., Groton, CT. TN. • Principles and Pitfalls of Hormone Measurements in Toxicology • Molecular Mechanism of Metal Toxicity: Signal Transduction and Studies, Terry M. Nett, Colorado State University, Fort Collins, CO. Oxidative Stress, Anumantha Kanthasamy, Iowa State University, Ames, IA. • Animal Models Used in Metal Toxicological Research, Janelle Crossgrove, Purdue University, West Lafayette, IN.
up-to-date information at www.toxicology.org 51
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harmacologic Expectations and Toxicological , John K. Leighton, FDA, Rockville, U.S. MD. , P
(Continued) Annual Annual Same? Kerry L. Blanchard, Eli Lilly & Company, Greenfield, IN. Cancer Drugs Considerations for Targeted Therapies, Myrtle A. Davis, Eli Lilly & Company, Greenfield, IN. Tomaszewski, Joseph E. Paradigm? Is this the Correct to BEDs: National Cancer Institute, Rockville, MD. Joseph & Pathology,Beyer, Toxicology Genetech, Inc., South San Francisco, CA. th Regulatory and Safety Evaluation SS* Evaluation Regulatory and Safety Comparative and Veterinary SS Veterinary and Comparative Over the past decade, a range developed of that targeted are anti-cancerdesigned to drugs interfere have molecular withbeen mechanisms that one drive tumor or growth. The moremolecularly-targeted of the manyapproach to the development of these new anti-cancer drugs has created a anti-cancer drugs, earlier cytotoxic falseunlike impression that these newer drugs, will be non-toxic. Cytotoxic drugsshort arecourses typicallyof administeredmaximal dosesin (MTD). This is not necessarily appro PM 08 (REPEAT OF AM 02) AM OF PM 08 (REPEAT IN and Greenfield, & Company, Eli Lilly Reddy, Vijayapal Chairperson(s): IN. Greenfield, Company, & A. Davis, Eli Lilly Myrtle by: Endorsed pre-clinical, and clinical targeted anti-cancer drug development. The first speaker will focus on tumor cell biology and the respective cell signaling pathways that hold promise for targeted anti-cancer therapy. The speaker second will present differences in pre-clinical betweendevelopment philosophycytotoxic and targetedwill discussanti-cancer specific drugs.examples ofbiotherapeutics. The The pre-clinicalfourth third speaker developmentwill speakerdiscuss biomarkersof as targetedendpoints of clinical efficacy and safety assessment. The final speaker will focus on regulatory considerations of of pre-clinical targeted therapies, development highlighting differences between cytotoxic and advanced course targetedin drug therapies. development is targeted This to government, biotech priate for targeted therapies, whichfor which canit is requireoften difficult long-termto determine the therapybiologically most dosage effective and (BED). This course will focus on different aspects of regulatory, nology and pharmaceutical toxicologists as well as generalwith an interest in cancer chemotherapy. toxicologists • Identification • Anti- of Non-Clinical Development for Regulatory Considerations • Drugs Targeted to MTD and of Cytotoxics The Development • Biotherapeutics Anti-Cancer of Safety Evaluation Pre-clinical TARGETED THERAPEUTIC APPROACH TO ANTI-CANCER ANTI-CANCER TO APPROACH THERAPEUTIC TARGETED DEVELOPMENT DRUG • the the Biomarkers Are Toxicity: Targeted Efficacy and Targeted 45 52 ------Meeting & ToxExpo & Meeting , Danuta, BASIC BASIC , Patrick J.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
, Human Risk Assessment and Clinical Immune Biomarkers, Ian
Kenneth L. Hastings, CDER Kenneth OfficeFront? New Drugs, of FDA, U.S. Rockville, MD. Approach A Pathologist’s and Immunophenotyping: AstraZeneca,Haley, Wilmington, DE. Herzyk,J. GlaxoSmithKline, King Prussia, of PA. Data Gourley, Lilly Research Laboratories, Indianapolis, IN. Regulatory and Safety Evaluation SS Evaluation Regulatory and Safety Toxicologic & Exploratory Pathology SS* Pathology & Exploratory Toxicologic Immunotoxicology SS Immunotoxicology Increased focus has been placed on evaluating immunotoxicity, particularly Increased focus has been immunotoxicity, placed on evaluating immunosuppression, in pharmaceutical development of small and molecules biologics following recent issuanceFDA and CPMP and current ICH ofdiscussions on harmonization.Toxicolo regulatory guidelines from : Brian G. Short, Allergan, Inc., Irvine, CA. Inc., Irvine, Allergan, Short, Chairperson(s): Brian G. by: Endorsed DEVELOPMENT AM 07 PRACTICAL STRATEGIES FOR EVALUATION OF FOR EVALUATION STRATEGIES PRACTICAL IN PHARMACEUTICAL IMMUNOSUPPRESSION • Studies Toxicity Signal Detection in Standard Immunosuppression • Imunosuppression of Evaluation Functional Assay: to Assay • of Non-Clinical Immunotoxicity Interpretation Viewpoint: Clinical typing or functional immune alterations. The toxicologist in is communicatingalso central the risk to clinicianspretation of and non-clinical regulatorsimmunotoxicology data followingand participatinginter in search the for clinical immune biomarkers to participants. The ensuregoal of this clinicalcourse is to safetydiscuss regulatory of guidance and trial use case examples to illustrate the pathology integrationand of toxicology, immunology in addressing both recent scientific approachesadvances inand thepractical pharmaceutical company setting edgeand impacted how thisclinical knowl trials and labeling, with a immunosuppression.focus on drug-induced Similarities immunotoxicity andguidance documents differencesand recent progress inin ICH FDA nization harmo will andbe discussed. CPMPSignal detection, including data from standard toxicity studies and the controversies among gists toxicologistsin following the and guidelines will patholo be addressed, including the recently drafted Best Practice Guideline for the Routine Pathology of the Immune System by the STP Immunotoxicology Working Group. typing Immunophenoconducted by flow cytometry or lymphoid immunohistochemistry will cover recent advances with case studies. Functionaldependent T-cell antibody assays, response, such natural as killer cell activity, host resis tance macrophage/neutrophil function, and cell-mediated be immunity discussed willwith regard to design and timing in drug development an from immunotoxicologists perspective. interpretation Finally, of non-clinical immunotoxicology data for risk assessment in will be featured. clinical immune biomarkers clinical trials and use of • on the ICH Harmonization New What’s Immunotoxicology:
gists, pathologists, immunologists and clinicians in the drug industry faced are with the challenge of addressing the intent of the documents current in a guidance scientifically valid and responsible An manner. integrated approach is necessary to provide a weight of evidence for signal detection in routine toxicity studies as well as conducting or immunotoxicityadding studiesendpoints in routine toxicity studies to assess immunopheno Continuing Education Education Continuing
CE 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Continuing Education (Continued) CE REPRODUCTIVE TOXICITY TESTING: STUDY DESIGNS, FUNCTIONAL ANALYSIS OF GENE AND PROTEIN EVALUATION, INTERPRETATION, AND RISK ASSESSMENT EXPRESSION: FROM EXPERIMENTAL DESIGN TO DATA ANALYSIS PM 09 (REPEAT OF AM 03) BASIC PM 10 ADVANCED Chairperson(s): Donald G. Stump, WIL Research Laboratories, LLC, Ashland, OH. Chairperson(s): Richard S. Pollenz, University of South Florida, Tampa, FL. Endorsed by: Regulatory and Safety Evaluation SS Endorsed by: Reproductive and Developmental Toxicology SS* Mechanisms SS* Risk Assessment SS The mechanistic analysis of cellular responses to xenobiotics requires the This course is intended to provide a general overview for scientists respon- functional characterization of changes in both gene and protein expres- sible for the design, conduct, and monitoring of reproductive toxicity sion. The ability to study changes to both genes and proteins in vitro and studies. The course will focus on reproductive biology, study design in vivo has become accessible to more laboratories with the development considerations, reproductive endpoints, data interpretation, and use of of molecular tools such as microarrays, siRNA, recombinant protein data in risk assessment. Reproductive toxicity studies are among the most expression, and viral gene delivery. However, the ability to utilize these complex and challenging studies in the field of toxicology. The studies techniques and generate reproducible results requires a detailed under- assess multiple interrelated endpoints of male and female reproductive standing of each procedure. Thus, the goal of this course is to provide function. In order to properly design, conduct and interpret these studies, a the investigator with an overview of experimental design and the use of fundamental knowledge of male and female reproductive system develop- proper controls for four cutting-edge techniques. The first talk will focus ment, anatomy, physiology, and endocrinology are required. This course on experimental design and analysis of gene expression studies utilizing will discuss the designs of reproductive studies for regulatory submis- microarrays. The second presentation will discuss recent advances in the sion. Individual lectures will discuss the anatomy and physiology of the chomatin-immunoprecipitation (ChIP) assay for the analysis of protein male and female reproductive systems as well as endocrine regulation of interactions at the level of DNA. The third presentation will discuss gene these systems. Evaluation of toxicity endpoints to assess male and female delivery into hepatocytes in vivo utilizing the adenovirus system. Finally, reproductive function will also be discussed including mating, fertility, the last presentation will discuss the advantages and disadvantages of estrous cyclicity, spermatogenesis, sexual behavior, parturition, reproduc- recombinant protein expression in cultured cells with emphasis on the tive hormone analysis, nesting and nursing behavior, reproductive organ level and functionality of the expressed protein and the use of siRNA. The weights and histopathology, and proper use of statistical analysis. The course will be of broad interest to those laboratories considering contem- course will conclude with discussions on some common issues related porary mechanistic approaches to gene and protein expression as well as to reproductive toxicity testing, interpretation of results, and how these those currently investigating these endpoints. results are ultimately used to assess potential risks to human reproduction. In summary, this course will present the key information required for the • Design and Analysis of Microarray Experiments, Thomas Sutter, design of reproductive toxicity studies and interpretation of reproductive Feinston Center for Genomic Research, University of Memphis, toxicity data and provide guidance for use of the data for risk assessment of Memphis, TN. human reproduction. • Analysis of Protein−DNA Interactions Using Chromatin−Immunop • Reproductive Toxicity Testing: Study Designs and General recipitation (ChIP), Eli Hestermann, Furman University, Greenville, Considerations, Barry S. McIntyre, Schering Plough Research SC. Institute, Lafayette, NJ. • Adenovirus−Mediated Gene Delivery to Alter Protein Expression In • Male Reproduction: Biology and Toxicity Endpoints, Kok Wah Hew, Vivo, Cornelis Elferink, UTMB, Galveston, TX. Purdue Pharma LP, Ardsley, NY. • Basics of Recombinant Protein Expression and RNA Interference • Female Reproduction: Biology and Toxicity Endpoints, Christopher in Cultured Cells, Richard S. Pollenz, University of South Florida, J. Bowman, WIL Research Laboratories, LLC, Ashland, OH. Tampa, FL. • Reproductive Toxicity Testing: Data Interpretation and Risk Assessment, Rochelle W. Tyl, RTI International, Research Triangle Park, NC.
up-to-date information at www.toxicology.org 53 -
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(Continued) Annual Annual An Introduction to the Nervous System, David C. Dorman, CIIT Centers for Health Research, Research Triangle Park, NC. Practical Methods in Rodent Neuropathology, Butt, Mark T. Pathology Associates, Frederick, MD. Oh, Aching My Head: Toxicant-Induced Neuropathology of the Central Nervous System, Brad Bolon, GEMpath Inc., Cedar City, UT. Morphologic Assessment of the Peripheral Nervous System, Quantitative Morphology in Rodent Neuropathology, Karl Jensen, Research EPA, U.S. Triangle Park, NC. William M. Valentine, Vanderbilt University, Nashville, TN. th Toxicologic & Exploratory Pathology SS* Pathology & Exploratory Toxicologic Neurotoxicology SS Neurotoxicology Comparative and Veterinary SS Veterinary and Comparative This course is designed to provide a basic overview of rodent neuropa • • • • • NEUROPATHOLOGY FOR THE TOXICOLOGIST THE FOR NEUROPATHOLOGY PM 12 Research, Health for Centers Chairperson(s): David C. Dorman, CIIT NC. Park, Triangle Research by: Endorsed thology. thology. The course will start off with and a histology of the review adult nervous system. This of will overview also discuss the normal anatomy the ways in which neuropathology and functional assays of motor activity and other behaviors relate to one another. tissue The handling second techniques lectureand basicrelates approaches to in neuropathology. This topic is critically important since the ability neuropathology to requires detect proper chemical-inducedtissue fixation and processing. the Althoughsecond lecture will largely focus on rodent tissues, the approaches and methods to be discussed can be easily adapted to other The species. course will then transition into two presentationsinduced by model focused neurotoxicants. One on presentation commonwill focus lesionson nervouscentral system effects while the neuropathies. Our final presentation latterwill discuss morphometric approaches lecture will address in neuropathology peripheral including a discussion of the use of magnetic resonance imaging methods Participants in in pathology. neurotoxicologic this course will gain a greatly improved appreciationapplications to toxicology. of basic neuropathology and 45 54 - - Meeting & ToxExpo & Meeting
BASIC 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Importance of Renal Transporters in Chemical Disposition and JohnToxicity, Pritchard, B. NIEHS, Research Triangle Park, NC. Clinical and Pharmacological Implications of Transporters in the Intestine and Blood-Brain Barrier, Jashvant Unadkat, D. University Washington,of Seattle, WA. Overview of the Families of Transporter Responsible for the Absorption, Distribution, and Excretion of Drugs, Curtis D. Klaassen, University Kansas of Medical Center, Kansas KS. City, Pharmacological and Toxicological Significance of Hepatic Transporters, Bruno Hagenbuch, University Kansas of Medical Center, Kansas KS. City, Drug Discovery Toxicology SS* Toxicology Drug Discovery • • • brain will be discussed. • PM 11 and Malvern, PA Sanofi-Aventis, A. Keller, Chairperson(s): Douglas Toxicologists have traditionally considered that chemicalsand distributed throughout the body due largely to their arelipid solubility and absorbed diffusivity through cell membranes. We also asconsider a drugprocess metabolismthat makes chemicals more it was pass readily cell membranes and be more excreted. However, waterrapidly soluble so they will less not understood how the water-soluble metabolite could exit the cell to be excreted. During the last decade a number of transportersbeen identi have XENOBIOTIC TRANSPORTERS XENOBIOTIC Curtis D. Klaassen, University of Kansas Medical Center, Kansas City, KS. Kansas City, Kansas Medical Center, of University Klaassen, Curtis D. by: Endorsed
fied that not only are responsible for the excretion of chemicals, but for the absorptionThis course, highlighting and distribution of also xenobiotics. the progress made in this research field as both timely and interest to of a significant large number of SOT members who are in academic, govern ment and industrial sectors. Thisfamilies of coursetransporters involved in willabsorption, distribution giveand excretion an ofoverview drugs of and the chemicals, as welltissues as where presentationstransporters are specificknown to to influencetransporters the in toxicity. majorThedisposition and roles toxicity of in the liver, kidney, intestine, and Continuing Education Education Continuing
CE 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Continuing Education (Continued) CE ASSESSING AIRWAY INJURY AND REMODELING INDUCED BY INHALED POLLUTANTS USING MAGNETIC RESONANCE IMAGING, MICROSCOPY, AND MODELING
PM 13 BASIC
Chairperson(s): Jack R. Harkema, Michigan State University, East Lansing, MI and Richard Corley, Pacific Northwest National Laboratories, Richland, WA.
Endorsed by: Inhalation SS*
The goal of this course is to present state-of-the-art methods of assessing injury and remodeling of the conducting airways caused by acute or chronic exposures to airborne toxicants including environmental pollut- ants (e.g., particulate matter, ozone, cigarette smoke, fungal, and bacterial toxins). The nature, severity, and distribution of airway lesions caused by these inhaled toxicants are due to an integration of several factors including the physicochemical characteristics of the inhaled toxicant (e.g., size of the particles, reactivity of the gas), the exposure regimen (e.g., short-versus long-term, continuous versus episodic), local intra-airway dosimetry (e.g., hot spots of deposition at airway bifurcations, slow clearance from sites of overload), and cellular susceptibility (e.g., sensitive versus resistant epithelial cell types). Toxicant-induced alterations to the airway structure range from oncotic or apoptotic cell death of epithelial cells lining the luminal surface with concurrent acute inflammation to marked remodeling of the airway wall due to intramural fibrosis, epithelial hyperplasia/meta- plasia, and chronic active inflammation. The strengths and limitations of a variety of state-of-the-art imaging techniques for visualizing macroscopic changes to the respiratory tract, including magnetic resonance imaging and computed tomography, will be presented along with those of more routine methods of light, electron, and confocal microscopy for assessing tissue and cellular pathology caused by inhaled pollutants. The funda- mental principles of airway stereology will also be presented and how these mathematically proven morphometric techniques may be used to quan- tify, without bias, changes to these tubular structures in order to estimate severity of complex lesions. Finally, presenters will describe the develop- ment and implementation of computational models of geometrically correct upper and lower airways used to define, site-specific, dose-response rela- tionships along the respiratory tract of laboratory animals and to estimate the risk of air pollutant exposures to human health. • An Overview of Airway Injury and Remodeling Caused by Inhaled Toxicants: From the Nose-to-the-Lung and from Gases to Particles, Jack R. Harkema, Michigan State University, East Lansing, MI. • State-of-the-Art Techniques for Imaging the Upper and Lower Respiratory Tract: Identifying Macroscopic to Microscopic Airway Alterations Caused by Airborne Toxicants, Charles Plopper, University of California-Davis, Davis, CA. • Sampling, Stereology, and Statistics: Quantifying Changes Along Tubular Structures and Without Bias, Dallas Hyde, University of California–Davis, Davis, CA. • Using Computer-Assisted Airway Reconstruction to Define Dose- Response Relationships, Julia Kimbell, CIIT Centers for Health Research, Research Triangle Park, NC.
up-to-date information at www.toxicology.org 55 Annual Meeting Annual th SOT's 45 SOT's
Annual Annual th 45 56 Meeting & ToxExpo & Meeting 45th Annual Meeting and ToxExpo and Meeting Annual 45th Notes
CE 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description All Scientific Sessions and Special Events will be held in the San Diego Convention Center unless otherwise noted. Saturday
Saturday, March 4 Friday 9:00 AM to 5:00 PM Marriott Hotel & Marina Columbia Room Friday, March 3 9:00 AM to 5:00 PM HESI/SETAC IN VITRO ADME BIOACCUMULATION Marriott Hotel & Marina WORKSHOP Columbia Room Details for this workshop can be found under the Friday, March 3 listing of HESI/SETAC IN VITRO ADME BIOACCUMULATION this event. WORKSHOP Saturday, March 4 The ILSI Health and Environmental Sciences Institute’s (HESI) Develop- 2:00 PM to 5:00 PM FRI/SAT/SUN ment of Methods for a Tiered Approach to Assess Bioaccumulation of Room 14B Chemicals Subcommittee and the Society of Environmental Toxicology and Chemistry (SETAC) are jointly hosting a workshop March 3–4, 2006 COMMITTEE CHAIR ORIENTATION to explore the range of in vitro techniques that may be applied to evaluate the bioaccumulation potential of chemicals. If you will be a Committee Chairperson in 2006–2007, please make plans to attend the Committee Chairperson Meeting scheduled for 2:00 PM– HESI is a global branch of the International Life Sciences Institute, a 5:00 PM, Saturday, March, 4. With new committee assignments taking public, non-profit scientific foundation with branches throughout the effect on May 1, 2006, the meeting is intended to provide new (and current, world. HESI provides an international forum to advance the understanding if desired) chairpersons with a basic tutorial on the SOT structure, opera- and application of scientific issues related to human health, toxicology, tion, and strategic direction. For additional information, please contact risk assessment and the environment. HESI is widely recognized among SOT Headquarters. scientists from government, industry and academia as an objective, science- based organization within which important issues of mutual concern can be discussed and resolved in the interest of improving public health. Saturday, March 4 5:30 PM to 9:00 PM The need for this workshop has come about as a result of growing concerns Room 16A regarding the persistence, bioaccumulation, and toxicity of substances (PBTs) released into the environment. New laws resulting from enactment UNDERGRADUATE EDUCATION PROGRAM of the United Nations Stockholm Convention (Persistent Organic Pollutants (POPs) Protocol) in May 2004 have led to significant new activity in the Chairperson(s): Peter Thomas, CDI Chair, Covance Laboratories, assessment of PBTs. To address the scientific challenges associated with Madison, WI and Alice Villalobos, University of Rochester, Rochester, NY. developing bioaccumulation assessments for the many chemicals that need Sponsored by: to be assessed in the coming years, there is a need to develop efficient, Committee for Diversity Initiatives scientifically-defensible alternatives to existing methods. Domestic and international reporting requirements are facilitating the development of Event for undergraduate students and advisors receiving MARC travel collaborative arrangements among industry, government, and academic funding, and the SOT program volunteers. scientists to identify additional methods for assessing thousands of chemi- cals. 5:30 PM–6:00 PM Orientation for SOT Hosts, Peer Mentors, and Advisors (Room 19) During the workshop, recommendations will be developed for using in vitro techniques for estimating bioaccumulation. In addition, the workshop 6:15 PM–7:00 PM Opening Event will seek to identify a path forward for achieving widespread acceptance of 7:15 PM–7:45 PM Dinner these techniques. Finally, a strategy will be developed for validating these techniques. The workshop proceedings will be submitted for publication in 7:45 PM–8:30 PM Opening Lecture: “What is Toxicology?” the peer-reviewed literature. Craig Marcus, University of New Mexico, Albuquerque, NM. The workshop will be held March 3–4, 2006 in the Columbia Room at the San Diego Marriott Hotel and Marina. Space for the workshop is limited, 8:30 PM–9:00 PM Dessert and Networking and participants will be accommodated on a first-come basis. To register for the workshop, contact Mr. Eric Moore, of HESI, at (202) 659–3306 or [email protected]. Registration information can also be found on the HESI website at www.hesiglobal.org.
up-to-date information at www.toxicology.org 57
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Students, Richard Peterson, University of Wisconsin, Madison, WI. Student Diversity, Mary Ann Smith, University of School PublicTexas of Health, Houston, TX. Directors and Research Sponsors Treinen-Moslen, University Medical Texas of Branch, Galveston, TX.
AWARDS CEREMONY AWARDS
Genome: The Secret of How Life (http://genome.pfizer. Works
C (Continued) Annual Annual
th Committee for K–12 Education Committee for The SOT Committee on K–12 Education has arranged for free admis 10:00 AM to 5:00 PM 10:00 Balboa Park PARACELSUS EVENT: K–12 COMMITTEE OUTREACH San Diego Natural History Museum Natural San Diego PERFOMANCE BY THE SAN DIEGO UNIVERSITY CHORAL PERFOMANCE BY 5:15 PM to 6:30 PM Room 6 : Stacie Wild, Amgen, Thousand Oaks, CA and Amgen, Wild, Chairpersons: Stacie 4:45 PM to 5:15 PM Room 6C SCHOLARS The San Diego Choral Scholars will after performthe This 2006 Ceremony. Awards world-traveling mixed priorensemble is to and immediately composed of a dozen undergraduate singers from San Diego State Univer 1:15 PM–1:55 PM PM PM–1:55 1:15 AnAdmissions Committee Perspective on 2:00 PM–2:40 PM Mentoring Diverse Undergraduates, Mary Paracelsus will guide you, your children, teachers, and everyone through the exhibit com/). Special activities and displays provided by SOT will correlate toxi Sunday, March 5 5 March Sunday, Join the Society in recognizing and honoring distinguished as toxicologists Ceremony. Awards at the SOT prestigious awards receive they Ken McMartin, Louisiana State University Health Science Center, Health Science Center, McMartin, Louisiana State University Ken museum exhibit. in a fun and informative cology Directions for public transportation site. to Web Annual Meeting 2006 Balboa description on the SOT event Park are linked from the 5 March Sunday, All attendees are welcome. sity. 5 March Sunday, sion to the San Diego Natural History Museum in Balboa is the important discipline and of genomics, toxicology cology how explain Park! to our health, and encourage exploration of toxicology careers. The main goal of the event is to enhance science education by stimulating children, teachers, and parents to learn about science and multidisciplinary toxi Shreveport, LA. Shreveport, by: Sponsored EXPLORES THE GENOME: TOXICOLOGY ADVANCES HEALTH ADVANCES TOXICOLOGY THE GENOME: EXPLORES For Advisors:For PM 12:30 PM–1:10 Tips for Advising Prospective Graduate All Participants: 3:00 PM–5:00 PM Open Time with Academic Program Toxicology 45 58
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Philbert, University Michigan, of Ann Arbor, MI. about Weapons Mass Iraq’s of Destruction, Robert Casillas, Battelle, Columbus, and OH Medical Service Corp, Army U.S. Reserve. Wildlife: Lessons from the Swamp, Louis for Discussion with Program Directors, sessions, each repeated three times WhatA) is Graduate School and What Can I Expect?, Adrian Nanez, University Louisville, of Louisville, KY and Jennifer Rayner, University of Gillette, University Florida,of Gainesville, FL. an Immunology Lab Ended up Studying Reproductive Paige B. Lawrence, Biology, Washington State University, Pullman, WA. University North of Carolina-Chapel Hill, Chapel Hill, NC. Internship Hosts, and Poster Presenters, Vicente LP, Woodlands,LP, TX, and Antonio Baines, Santa Cruz, Chevron Phillips Chemical Company North Carolina Chapel Hill, Chapel Hill, NC. B) to How Get into Graduate School: An Academic Advisor’s Perspective, Heather Kleiner and Tammy Dugas, Louisiana State University Health Science Center, Shreveport, LA. C) What Road Should Suggestions I Take? Sunday
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Committee for Diversity Initiatives Diversity Committee for The Sunday program is open to undergraduate students who registered for this event on the Annual Meeting Registration students Form, and advisors the receiving MARC undergraduateand Pfizer travel funding, and the volunteers. program SOT 8:00 AM–9:45 AM Special Lectures Toxicology AM–8:558:15 AM Nanotechnology and Martin Related Toxicology, 8:55 AM–9:30 AM in Role Search A Toxicologist’s for the Truth 9:30 AM–9:45 AM Break 9:45 AM AM–10:15 Contaminants, Endocrine Disruption, and
8:00 AM to 5:00 PM 8:00 Program Description Description Program UNDERGRADUATE EDUCATION PROGRAM EDUCATION UNDERGRADUATE Laboratories, Covance Thomas, CDI Chair, Chairperson(s): Peter Room 16A Sunday, March 5 March Sunday, Woodlands, TX. Woodlands, by: Sponsored
Madison, WI and Vicente Santa Cruz, Chevron-Phillips, The Chevron-Phillips, Santa Cruz, Vicente WI and Madison, 10:15 AM–10:30 AM10:15 Undergraduates and Research: TBA AM 10:30–11:30 Developmental Immunotoxicity Dioxin: of How 11:30 AM–12:30 PM 11:30 Lunch Students:For 12:30 PM–2:45 PM Break out Sessions, 40-minute, concurrent
FRI/SAT/SUN 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Sunday, March 5 6:30 PM to 7:30 PM Monday Morning Sails Pavilion
Monday, March 6 WELCOMING RECEPTION 8:00 AM to 2:00 PM Room 16B Join us on as SOT kicks off its 45th Anniversary Celebration. This will be a memorable evening of reminiscing with friends, good fun, and looking UNDERGRADUATE EDUCATION PROGRAM to the future of SOT. Please join the Society in this inaugural event of the Annual Meeting. Enjoy complimentary hors d’oeuvres; a cash bar will be Chairperson(s): Peter Thomas, CDI Chair, Covance Laboratories, available. Madison, WI and Javier Avalos, TopTox, Sacramento, CA. Sponsored by: Sunday, March 5 Committee for Diversity Initiatives 7:00 PM to 8:00 PM Room 4 Event for undergraduate students and advisors receiving MARC travel funding, and the SOT program volunteers. 8:00 AM–8:15 AM Meeting of Students, Advisors, Peer Mentors, 25-YEAR (OR MORE) MEMBER RECEPTION and SOT Hosts Have you been a member of the Society of Toxicology for 25 years (or 8:30 AM–9:15 AM Plenary Lecture: Risk Communication, David more)? If so, please consider joining your colleagues in this 45th Celebra- Ropeik, Harvard University, Boston, MA. tion and recognition of the scientists who established the Society. Invitation is required. 9:30 AM–11:15 AM Special Poster Session for Visiting Students 11:30 PM–2:00 PM Lunch, Career Panel, Discussion, and Closing Sunday, March 5 Session 7:30 PM to 8:30 PM Room 33 Monday, March 6 8:30 AM to 9:15 AM STUDENT/POST-DOCTORAL FELLOW MIXER Room 6 The Student Advisory Committee hosts this opportunity for students PLENARY LECTURE: RISK COMMUNICATION—THE MONDAY and post-doctoral fellows to gather, to meet new colleagues, and to PERCEPTION GAP, AN UNRECOGNIZED ASPECT OF RISK re-establish relationships in an informal atmosphere at the beginning of the meeting. If you register for this event on the Annual Meeting Registration Lecturer: David Ropeik, Harvard School of Public Health, Harvard Form, you will receive a ticket at no charge. Ticket and meeting badge are University, Boston, MA. required. Complimentary refreshments and a cash bar will be available. This talk will propose that the classic definition of Risk Sunday, March 5 = Hazard x Exposure is incomplete. A definition that 8:00 PM to 9:00 PM more fully reflects all aspects of risk is Hazard x Expo- Room 32 sure x Perception. While it is often said that people are wrong or irrational when their fears don’t match the POST-DOCTORAL ASSEMBLY EVENT facts, their fears are real, and those fears often lead to behaviors that compound the risk to themselves and Join your post-doc colleagues, after a visit to the Student/Post-doctoral to society. The scientific understanding of the roots of Fellow Mixer, at the Post-doctoral Assembly Event. The Post-doctoral risk perception will be explained. More effective risk Assembly (PDA) is the formal group for these members. Take this oppor- communication, based on a respect for the realities of risk perception, will tunity to network with each other, discuss issues of importance to you, plan be offered as a vital tool for closing ‘The Perception Gap’ and encouraging activities, and get to know the members of the 2006–2007 PDA Board. The people to make more informed and healthier choices. featured speaker is Jose Manautou, 2006 Achievement Award recipient. Light appetizers and cash bar will be available. Monday, March 6 9:30 AM to 11:15 AM Exhibit Hall
POSTER SESSION FOR VISITING STUDENTS
Chairperson(s): Javier Avalos, TopTox, Sacramento, CA.
Sponsored by: Committee for Diversity Initiatives
This poster session is part of the Undergraduate Education Program. All are welcome to view the specially selected presentations which provide an overview of research in toxicology and demonstrate the diversity within the discipline. up-to-date information at www.toxicology.org 59 -
Inst. 1 . 4 .
Center for M. Runge- 2 Bloomberg School Bloomberg 3 Annual Meeting Annual D. W. Hein W. and D. th 3 Department of Pharmacology 4 SOT's 45 SOT's T. Kensler , T. 2 Center for Pharmacogenetics and Center for Pharmacogenetics 2 . Environmental Health . Environmental Kensler W. T. , W. Xie W. , 1 Center for Pharmacogenetics, University University Center for Pharmacogenetics, 1 .
1 of Public Health, Johns Hopkins University, Health, Johns Hopkins University, of Public Morris Detroit, MI, Baltimore, MD and Xie Sciences, Johns Hopkins University, Baltimore, MD. Sciences, Johns Hopkins University, Pharmacogenetics, University of Pittsburgh, of Pittsburgh, University Pharmacogenetics, Sponsor: M. Runge-Morris PA. Pittsburgh, REGULATION OF PHASE 2 ENZYMES REGULATION THE KEAP1-NRF2 SIGNALING THROUGH PATHWAY. Department of Pharmaceutical Sciences, University Department of Pharmaceutical Sciences, University PA, Pittsburgh, of Pittsburgh, REGULATION OF PHASE II XENOBIOTIC XENOBIOTIC OF PHASE II REGULATION IMPLICATIONS ENZYMES: METABOLIZING AND DISEASE. FOR HEALTH . Inst.Envir.Health Sciences., . Inst.Envir.Health M. Runge-Morris MI. Detroit, State University, Wayne OF UDP GLUCURONOSYL REGULATION THE ORPHAN TRANSFERASES BY W. SUPERFAMILY. NUCLEAR RECEPTOR & Toxicology, University of Louisville, Louisville, University Toxicology, & KY. TRANSCRIPTION FACTOR OF ROLE OF THE CONTROL IN NETWORKS GENE EXPRESSION. SULFOTRANSFERASE Envir.Health Sciences., Wayne State University, State University, Wayne Sciences., Envir.Health of Pittsburgh, Pittsburgh, PA and PA Pittsburgh, of Pittsburgh,
(Continued) Annual Annual th Molecular Biology SS* Molecular Biology 9:30 AM to 12:00 NOON 9:30 Room 8 OF PHASE II REGULATION SYMPOSIUM SESSION: IMPLICATIONS ENZYMES: METABOLIZING XENOBIOTIC DISEASE AND FOR HEALTH Detroit, State University, Wayne Melissa Runge-Morris, Chairperson(s): MI. by: Endorsed The tight regulation of phase II xenobiotic-metabolizing enzymes such as the sulfotransferase (SULT), UDP-glucuronosyl acetyltransferases transferaseand(NAT) glutathione-S-transferases (UGT), (GST) N- multigene families, represents an essential componentpopulations, geneticof detoxication.polymorphisms Indetermine human andthe NAT2 phenotypeand togetherof NAT1 with tissue-specific cancer gene risk expression,following influenceexposure to aromaticthe environment.and heterocyclicEmerging amines insightsin demonstrated in that the hepatic theand SULT UGT enzymes nuclearare not only coor receptor field have Monday, March 6 March Monday, #20 11:00 dinately regulated by members of the nuclear receptor superfamily, but also members of the nuclear by receptor superfamily, regulated dinately species that participate in nuclear of receptor bio-active modulate the levels signaling. Superimposed on these advances, the activation of the Nrf2 Keap1/ signaling pathway by oxidative stress mediators in the environment has been recently shown to control the expression of key members of the GST multigene family, as well as other xenobiotic-metabolizing enzyme target genes. This symposium will genomic provideand transcription an factor updatedcontrols that regulate analysisUGT, NAT SULT, on and GST theemphasis enzymes. will Focused be placed on the implications of in humans. for toxicity altered phase II enzyme gene expression #17 9:30 #19 10:15 #18 9:35 45 60 - Meeting & ToxExpo & Meeting . B. and B. 3
B. S. B. Eli Lilly Eli Lilly 2 Environmental & Environmental 3 B. S. Cummings B. V. E. Kagan , V. 2 . Eli Lilly K. Monteith. Eli Lilly D. . . Environmental . Environmental E. Kagan V. Environmental Medicine, Environmental 4 D. K. Monteith , D. 1 Pharmaceutical and Biomedical Sciences, 1 . 4
University of Georgia, Athens, GA, of Georgia, University B. Cummings Sponsor: B. PHOSPHOLIPIDOSIS. Cummings Greenfield, IN. & Company, OF PHOSPHOLIPID DETERMINATION DURING CHEMOTHERAPEUTIC- PROFILES INDUCED CELL DEATH. Pharmaceutical and Biomedical Sciences, University Pharmaceutical and Biomedical Sciences, University Athens, GA. of Georgia, PHOSPHATIDYLSERINE/ AND CARDIOLIPIN AND APOPTOSIS IN SIGNALING OXIDATIVE PHAGOCYTOSIS. Fadeel Greenfield, IN, & Company, LIPIDOMICS OF CELL DEATH. & Occupational Health, University of Pittsburgh, of Pittsburgh, & Occupational Health, University PA. Pittsburgh, OF LIPID RAFTS IN CELL DEATH: ROLE AND ACTIVATION APOPTOSOME FOCUS ON Environmental Fadeel. B. CHEMORESISTANCE. Medicine, Karolinska Institute, Stockholm, Sweden. Occupational Health, University of Pittsburgh, of Pittsburgh, Occupational Health, University and PA Pittsburgh, Karolinska Institute, Stockholm, Sweden. AND CHARACTERIZATION OF DRUG-INDUCED CONSEQUENCES 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Regulatory and Safety Evaluation SS Evaluation Regulatory and Safety Molecular Biology SS Molecular Biology Lipidomics, the study of the effect of death, area is emerging of and a research rapidly new with great promise lipidsin on cellular physiology membranes organelle and and cell up make Phospholipids toxicology. molecular properties are integral of to the maintenance their physical-chemical and by cell homeostasis. In addition, these molecules are critical to cell signaling Therefore, to pathways. toxicologists this cell often-overlooked component plays interesting, and often pivotal, roles in toxicity and pathogenesis. For example, studies on the roles of phospholipids apoptosis, during phagocytosis,phospholipidosis, oxidative stress and mitochondrialall candysfunction yield new and vital processes.information In aboutaddition, the a mechanismsvariety of of advanced such techniques for the assess #14 10:20 : Brian Cummings, University of Georgia, Athens, GA. of Georgia, Chairperson(s): Brian Cummings, University by: Endorsed 9:30 AM to 12:00 NOON 9:30 Room 6E OF CELL DEATH LIPIDOMICS SYMPOSIUM SESSION: Monday, March 6 March Monday, #15 11:00
ment of phospholipids have increased our ability to including perform flow lipidomics,cytometry, electrospray ionization-mass spectrometry and high Thus, performance lipidomics thin offers chromatography. layer great cell death. promise into identifying mechanisms of toxicant-induced #12 9:30 Program Description Description Program #16 11:40 #13 9:40
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #21 11:45 REGULATION OF THE HUMAN ARYLAMINE #26 11:50 RISK ASSESSMENT ISSUES RELATED TO N-ACETYLTRANSFERASES: IMPLICATIONS OLFACTORY TRANSPORT OF INHALED FOR CANCER SUSCEPTIBILITY. D. W. Hein, MATERIALS. M. E. Andersen. Computational A. Husain, J. States and D. F. Barker. Pharmacology Biology, CIIT-Centers for Health Research, Research and Toxicology, University of Louisville, Louisville, Triangle Park, NC. KY. Monday, March 6 Monday, March 6 9:30 AM to 12:00 NOON 9:30 AM to 12:00 NOON Room 5A Room 5B WORKSHOP SESSION: SCREENING METHODS FOR SYMPOSIUM SESSION: RISK ASSESSMENT IMPLICATIONS ASSESSING SKIN TOXICITY OF NANOMATERIALS OF DIRECT NOSE-TO-BRAIN TRANSPORT OF INHALED XENOBIOTICS Chairperson(s): Mary Jane Cunningham, Houston Advanced Research Center, The Woodlands, TX and Nancy Monteiro-Riviere, North Carolina Chairperson(s): David C. Dorman, CIIT Centers for Health Research, State University, Raleigh, NC. Research Triangle Park, NC and Jack R. Harkema, Michigan State University, East Lansing, MI. Endorsed by: Dermal Toxicology SS* Endorsed by: In Vitro SS Inhalation SS Metals SS Nanoscale materials (whether engineered or anthropogenic) are structures Neurotoxicology SS with characteristic dimensions between 1 and 100nm and are present at Toxicologic and Exploratory Pathology SS* ever increasing concentrations in the environment. Engineered nanomate- rials include the prototype C60 molecules, otherwise known as fullerenes The olfactory system is unique in that it forms a direct interface between or “Bucky balls”, nanowires, nanofibers, nanoscissors, and nanotubes. The the air and the central nervous system (CNS). There is growing evidence manufacture of these nanomaterials is scaling up to commercial levels. that metals and other xenobiotics deposited within the nose can be absorbed Their smaller size attributes additional physical properties, like conduc- at this site and then undergo transport along either the olfactory or trigem- tivity and reactivity, which allows them to be used in telecommunications, inal nerve, thus bypassing the blood-brain-barrier. One metal of special alternative energy sources, and medical applications. These engineered concern to be discussed in this symposium is manganese, a neurotoxic materials vary in their structures and physicochemical compositions. metal shown to be able to cross synapses in the olfactory bulb and migrate Currently, efforts are being made to standardize the manufacturing prac- via secondary olfactory neurons to more distant nuclei of the brain. In tices, analytical and detection methods and nomenclature. However, little is MONDAY some cases, direct olfactory transport is a major pathway by which an known about their toxicity and recent reports are conflicting. Dermal, inha- inhaled metal reaches the CNS. This symposium will present new discov- lation and oral exposure are all major probable routes of exposure. Since eries concerning direct nose-to-brain transport of metals in the olfactory the skin is the largest organ of the body, it may be the utmost concern in pathway. This symposium will also discuss likely mechanisms by which terms of human health. The presentations in this symposium will address transport occurs and inter-species differences in nasal anatomy that may the background of these nanomaterials and will focus on new screening play a role in metal olfactory uptake and transport. methodologies for assessing their cytotoxicity utilizing several types of #22 9:30 RISK ASSESSMENT IMPLICATIONS OF skin model systems. Methodologies will include assays for skin viability, DIRECT NOSE-TO-BRAIN TRANSPORT OF absorption, transport and gene expression and protein expression profiling. INHALED XENOBIOTICS. J. Harkema2, D. These presentations will provide a base line for interpretation of the toxico- C. Dorman1, G. Oberdorster3 and M. Andersen1. logical implications for occupational or potential environmental exposure 1CIIT Centers for Health Research, Research that could possibly be used in risk assessment. Triangle Park, NC, NC, 2Department of Food Safety #27 9:30 SCREENING METHODS FOR ASSESSING and Toxicology, Michigan State University, East SKIN TOXICITY OF NANOMATERIALS. N. Lansing, MI and 3Department of Environmental Monteiro-Riviere2 and M. Cunningham1. 1Houston Medicine, Rochester University, Rochester, NY. Advanced Research Center, The Woodlands, TX and 2North Carolina State University, Raleigh, NC. #23 9:50 COMPARATIVE NASAL STRUCTURE, FUNCTION AND TOXICOLOGY: #28 9:35 ASSESSING NANOMATERIAL IMPLICATIONS FOR THE RISK OF DIRECT INTERACTIONS IN SKIN. N. A. Monteiro- TRANSPORT OF INHALED XENOBIOTICS Riviere. Center for Chemical Toxicology Research TO THE BRAIN. J. R. Harkema. Pathobiology, and Pharmacokinetics, North Carolina State Michigan State University, East Lansing, MI. University, Raleigh, NC. #24 10:30 AN OVERVIEW OF NOSE-TO-BRAIN #29 10:10 GEL-BASED PROTEOMIC SCREENING TRANSPORT OF INHALED METALS. D. OF NANOTUBE TOXICITY IN HUMAN C. Dorman. CIIT Centers for Health Research, KERATINOCYTES. F. Witzmann1 and N. Research Triangle Park, NC. Monteiro-Riviere2. 1Cellular & Integrative Physiology, Indiana University School of Medicine, #25 11:10 NEURONAL TRANSLOCATION OF INHALED Indianapolis, IN and 2Center for Chemical NANO-SIZED PARTICLES: CAUSE FOR Toxicology Research and Pharmacokinetics, College CONCERN? G. Oberdorster. Environmental of Veterinary Medicine, North Carolina State Medicine, University of Rochester, Rochester, NY. University, Raleigh, NC. up-to-date information at www.toxicology.org 61
, 1 , J. , J. 2 , 3 and P. and P. 1 J. J. J. , J. U.S. U.S. 2 1 , K. R. , M. 1 . 6 1 R.
Biological Biological 2 Laboratory of 1 , S. Kabilan University University 1 2 . . University University CIIT Centers 4 5 , S. McBride 1, 2 1 S. Hussain , 1 Biology, University University Biology, Annual Meeting Annual , E. Postlethwait R. A. Corley R. 1 Air Force Research Air Force 2 Pacific Northwest 2 . th 1 1 L. Costa . J. R. Harkema , J. 1 5 and V. Benignus V. and University of Alabama of University , R. E. Jacob 2 3 1 . J. Freedman and J. SOT's 45 SOT's 1 GSK, Ware, United Kingdom. Ware, GSK, NSOEES, Duke University, Durham, University, NSOEES, Duke Gentronix Ltd., Manchester, United Gentronix Ltd., Manchester, 2 2 1 . Environmental and . Environmental M. Baird and W. . , E. A. Hoffman , E. 2 1 J. S. Kimbell , J. 4 . S. Dean and M. Hofmann C. Timchalk and C. 2 7 , D. R. Einstein R. , D. 1 Michigan State University, Lansing, MI and University, State Michigan , D. Snyder , D. 6 1
University of Washington, Seattle, WA. Seattle, Washington, of University of Dayton, Dayton, OH and Dayton, of Dayton, National Laboratory, Richland, WA, WA, Richland, National Laboratory, L. L. Trease L. L. COUPLING THE QCP INTEGRATIVE THE QCP INTEGRATIVE COUPLING THE AND HUMAN PHYSIOLOGY MODEL SIMULATE TO PBPK MODEL TOLUENE IN COMPLEX EXPOSURE SCENARIOS Rice NC. THROUGHPUT HIGH A HIGH SPECIFICITY, SCREENING GENOTOXICITY VITRO IN Walmsley CELLS. R. IN HUMAN ASSAY Kingdom and Sponsor: EFFECT OF SILVER NANOPARTICLES ON NANOPARTICLES EFFECT OF SILVER IN MALE GERM-LINE STEM ACTIVITY SRC CELLS. L. K. Braydich-Stolle Cambridge, MA. Sponsor: SCREENING TOXICOLOGICAL WORMTOX: THE NEMATODE USING TOOLS Boyd W. Caenorhabditis elegans. ADVANCEMENTS IN MODELING THE IN MODELING ADVANCEMENTS SYSTEM. RESPIRATORY Minard C. Plopper Hlastala CA, Davis, of California at Davis, NC, 7 Coleman T. HUMANS. Simulators, Inc., Jackson, MS. Sponsor: , E. Brooks, J. Atkin, M. J. Reimers, Atkin, M. J. , E. Brooks, J. Mahadevan B. Tanguay R. L. DeWoskin C. Willett, N. Roy, Y. Lin, C. Ton, C. Parng and Ton, Lin, C. Y. Roy, N. Willett, C. Pharmaceuticals, Inc., McGrath. Phylonix P. EPA, Research Triangle Park, NC and NC Park, Triangle Research EPA, W. Hastwell W. Laboratory, Wright Patterson Air Force Base, Air Force Wright Patterson Laboratory, OH. Dayton, ENZYME XPA ADDUCT REPAIR DNA BULKY DEVELOPMENT OF ZEBRAFISH. IN EARLY for Health Research, Research Triangle Park, Park, Triangle for Health Research, Research Molecular Toxicology, Oregon State University, State University, Oregon Toxicology, Molecular OR. Corvallis, ASSESSMENT OF DEVELOPMENTAL AFTER IN ZEBRAFISH NEUROTOXICITY TOXINS. ENVIRONMENTAL TO EXPOSURE of Iowa, Iowa City, IA, IA, City, Iowa of Iowa, Molecular Toxicology, NIEHS, Research Triangle Triangle NIEHS, Research Toxicology, Molecular NC and Park, at Birmingham, Birmingham, AL, AL, at Birmingham, Birmingham, Schlager
(Continued) Annual Annual th #36 11:15 #41 10:34 9:30 AM to 12:00 NOON 9:30 Room 15A MODELS FOR ALTERNATIVE SESSION: PLATFORM TOXICITY ASSESSMENT OF Air Force Wright Patterson Air Force, U.S. Schlager, Chairperson(s): John Corvallis, OR. State University, Oregon Mahadevan, OH and Brinda Base, #37 9:30 #40 10:18 #35 10:40 Monday, March 6 March Monday, #38 9:46 #39 10:02 45 62
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Meeting & ToxExpo & Meeting . in vivo R. S. and T. S. and T. 1
and 2 . S. M. Roberts in vitro
T. S. Poet T. R. S. DeWoskin U.S. EPA, Research Triangle Park, Park, Triangle Research EPA, U.S. 1 . 1 Pacific Northwest National Laboratory, Pacific National Laboratory, Northwest 2 U.S. EPA, Research Triangle Park, NC and Park, Triangle Research EPA, U.S. 1
. 2
PNNL, Richland, WA. PNNL, Richland, Ctr. Environment Human Toxicology, Univeristy of Univeristy Toxicology, Human Environment Ctr. NC and THE USE OF PHYSIOLOGY MODELS IN ASSESSMENT. RISK 2 THE PHYSIOME IN PHARMACOKINETICS, TOXICOLOGY. AND PHARMACODYNAMICS Florida, Gainesville, FL. GENE EXPRESSION PROFILING AND A AND PROFILING GENE EXPRESSION THE TO APPROACH SYSTEMS BIOLOGY MATERIALS. SCREENING OF NANOSCALE Research Advanced M. Cunningham. Houston TX. Woodlands, The Center, PENETRATION ASSESSING DERMAL AND BY LIGHT OF NANOMATERIALS MICROSCOPY. ELECTRON Poet J. B. Bassingthwaighte, A. Matuszkiewicz, M. A. Matuszkiewicz, Bassingthwaighte, B. J. E. Butterworth, G. M. Raymond, S. Park, J. Krueger, Washington, of M. Neal and M. Hlastala. University Sponsor: R. DeWoskin WA. Seattle, TOWARDS THE VIRTUAL HUMAN: ADDING HUMAN: VIRTUAL THE TOWARDS TO MORE PHYSIOLOGICAL DETAIL MODELS USED BASED BIOLOGICALLY ASSESSMENT. IN RISK DeWoskin Richland, WA. Richland, IN AND CHALLENGES CURRENT STATUS 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Risk Assessment SS Risk Mechanisms SS Biological Modeling SS* Modeling Biological Biologically based models have proven applications drugin development,risk andassessment, health care primarily based predict outcomes uponand extend the usefulness of their limited data sets. Biological ability to models also help integrate diverse sets of data from #34 10:05 studies (and the many “omics” technologies) into framework of a a coherent mode chemical’s of theoretical action. The most common biological models currently used in risk assessments are physiologically based phar : Robert DeWoskin, U.S. EPA, Research Triangle Park, NC Park, Triangle Research EPA, U.S. Chairperson(s): Robert DeWoskin, WA. Richland, National Laboratory, Northwest Pacific Poet, Torka and by: Endorsed Monday, March 6 March Monday, Room 2 HUMAN: VIRTUAL THE TOWARDS SESSION: WORKSHOP BIOLOGICALLY- TO ADDING MORE PHYSIOLOGICAL DETAIL MODELS BASED #31 11:20 AM to 12:00 NOON 9:30 #30 10:45
macokinetic (PBPK) models, which simulate the toxin, pharmacokinetics generally at the of whole body a and organ level. A natural outcome of the increased use of biological models in risk assessment is an interest in ever increasing levels of physiological detail, with the ultimate goal being a highly predictive whole body or virtual human model. Progress has been in slow; however, part because of a lack of interaction between the physi ology modeling community with its focus on medical applications and the PBPK modeling community with its focus on risk assessment. This work shop begins to bridge some of this gap by presenting an state of overview of physiology modeling, some the examples of systems level physiology models, a case study of a hybrid physiology/PBPK model with improved predictive capability, and a discussion of the challenges to using existing models in risk assessment. physiology #32 9:30 Program Description Description Program #33 9:35
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #42 10:50 IN VITRO ANALYSIS OF THE SENSITIZING #48 10:20 COST-EFFECTIVE OPTIMIZATION OF PROPERTIES OF OXIDATION A NEUROPATHOLOGY PROTOCOL FOR AND METABOLIC PRODUCTS OF USE IN REGULATORY DEVELOPMENTAL P-PHENYLENEDIAMINE AND P- NEUROTOXICITY STUDIES. D. De Groot1, TOLUYLENEDIAMINE. P. Aeby1, O. Goettel1, M. Otto1, M. Moerkens1, M. Waanders1, L. vd H. Beck1, L. Chassot1, F. Protopapa1, S. Rossier1 Horst1, S. Hartgring1, M. Pelgrim1, D. Waalkens1, and C. Goebel2. 1Toxicology, Cosmital SA, Marly, J. Lammers1, M. Bos1, W. Kaufmann2, J. Switzerland and 2Product Safety, Wella AG, O’Callaghan3, H. Gundersen4, M. Lundberg4, S. Darmstadt, Germany. Sponsor: F. Gerberick. Sorensen5 and B. Pakkenberg5. 1TNO Quality of Life, Zeist, Netherlands, 2NIOSH, Morgantown, #43 11:06 IN VITRO IDENTIFICATION OF CONTACT WV, 3BASF, Ludwigshafen, Germany, 4University, ALLERGENS TEST BASED ON THE Aarhus, Denmark and 5Res.Lab.Sterol.&Neurosc., 1, 3 ACTIVATION OF U937 CELLS. F. Python , Copenhagen, Denmark. Sponsor: V. Feron. C. Goebel2 and P. Aeby1. 1Toxicology, Cosmital SA, Marly, Switzerland, 2Product Safety, Wella #49 10:45 A FUNCTIONAL OBSERVATIONAL AG, Darmstadt, Germany and 3Supported by BATTERY (FOB) COMPARISON STUDY OF The European Cosmetic Toiletry and Perfumery 12 PYRETHROIDS IN RATS. L. P. Sheets1, D. Association, COLIPA, Brussels, Belgium. Sponsor: E. Sargent1, M. Nemec2, C. Breckenridge1, M. R. F. Gerberick. Creek1, L. S. Mullin1, J. Sharp1 and M. L. Weiner1. 1Toxicology Committee, Pyrethroid Working Group, #44 11:22 XENOBIOTIC METABOLIZING Research Triangle Park, NC and 2WIL Research ENZYME (XME) EXPRESSION IN THE Laboratories, LLC, Ashland, OH. EPIDERM IN VITRO HUMAN SKIN EQUIVALENT: UTILITY FOR ASSESSING #50 11:10 PRINCIPAL COMPONENTS AND FACTOR DERMAL BIOTRANSFORMATION OF ANALYSIS OF THE FUNCTIONAL PHARMACEUTICALS, COSMETICS AND OBSERVATIONAL BATTERY OF 12 ENVIRONMENTAL CHEMICALS. G. Stolper1, PYRETHRIODS. C. Breckenridge1, L. Holden2, D. J. Bolmarcich1, M. Aardema2, T. Hu2, R. D. Curren3, E. Sargent1, L. Sheets1, M. R. Creek1, L. S. Mullin1, M. Klausner1, J. Kubilus1 and P. J. Hayden1. 1MatTek J. Sharp1 and M. L. Weiner1. 1Toxicology Committee, Corp., Ashland, MA, 2Procter & Gamble Company, Pyrethroid Working Group, Research Triangle Park, Cincinnati, OH and 3The Institute for In Vitro NC and 2Sielkin Associates, College Station, TX. Sciences, Gaithersburg, MD. #51 11:35 NEIGHBORHOOD ENVIRONMENTAL
#45 11:38 COMPARATIVE EVALUATION OF STRESS MODIFIES THE EFFECT OF MONDAY BENZALKONIUM CHLORIDE ON IN LEAD ON COGNITION: THE BALTIMORE VITRO RABBIT AND HUMAN CORNEAS. MEMORY STUDY. T. A. Glass1, K. Bandeen- D. Ghate1, G. Holley1, D. Bagley2, M. Blazka2 Roche3, M. McAtee1 and B. S. Schwartz2. and H. F. Edelhauser1. 1Ophthalmology, Emory 1Epidemiology, Johns Hopkins Bloomberg School University Eye Center, Atlanta, GA and 2Research of Public Health, Baltimore, MD, 2Environmental and Development, Colgate-Palmolive company, Health Sciences, Johns Hopkins Bloomberg School Piscataway, NJ. of Public Health, Baltimore, MD and 3Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Monday, March 6 9:30 AM to 12:00 NOON Room 7B Monday, March 6 9:30 AM to 12:00 NOON PLATFORM SESSION: FRONTIERS OF NEUROTOXICOLOGY: Room 1A EXTRAPOLATION AND HUMAN HEALTH PLATFORM SESSION: GENE EXPRESSION CHANGES IN Chairperson(s): Stephanie Padilla, U.S. EPA, Research Triangle Park, NC CARCINOGENESIS and Larry Sheets, Bayer CropScience, Stilwell, KS. #46 9:30 A DOSE-RESPONSE STUDY OF THE Chairperson(s): Jay Goodman, Michigan State University, East Lansing, TOXICITY OF A MIXTURE OF 7 N-METHYL MI and Robert Smart, North Carolina State University, Raleigh, NC. CARBAMATE PESTICIDES IN ADULT, MALE #52 9:30 ALTERED METHYLATION IN GENE- RATS. S. Padilla1, W. Setzer2, R. S. Marshall1, D. L. SPECIFIC AND GC-RICH REGIONS IS Hunter1, P. Phillips1, K. McDaniel1, V. C. Moser1 and PROGRESSIVE AND NON-RANDOM DURING A. Lowit3. 1NTD, U.S. EPA, Research Triangle Park, PROMOTION OF SKIN TUMORIGENESIS. NC, 2NCCT, U.S. EPA, Research Triangle Park, NC A. N. Bachman1, G. M. Curtin2, D. J. Doolittle2 and and 3OPP, U.S. EPA, Washington, DC. J. I. Goodman1. 1Pharmacology and Toxicology, Michigan State University, East Lansing, MI and #47 9:55 EXPLORING THE USE OF 2Research and Development, R. J. Reynolds Tobacco CAENORHABDITIS ELEGANS AS A MODEL Company, Winston-Salem, NC. FOR MAMMALIAN NEUROTOXICITY USING CARBAMATE PESTICIDES. P. C. Melstrom and P. L. Williams. Environmental Health Science, University of Georgia - Athens, Athens, GA. up-to-date information at www.toxicology.org 63
, , 1 1 , 1 Cell 2
2 . 1 , K. 1 Food Food 1 . 2
, J. Hernandez- , J. 1 Radioisotope , K. Sato 3 3 Toxicology, Toxicology, A. M. Chaudhary 1
, M. J. Le Nedelec , M. J. , D. M. Owens M. , D. . 1 1 2 Pharmacology, Pharmacology, Annual Meeting Annual 1 New Zealand Institute New 2 . th 1 , T. Mori T. , 2 Direccion de Tecnologia Tecnologia Direccion de R. J. Rosengren and R. J. J. E. Trosko E. and J. 3 2 2 Environmental and Molecular Environmental Departments of Dermatology 1 , A. Sierra-Santoyo 2 SOT's 45 SOT's 2 . 1 , A. R. Menzies , 1 , C. Chang 1 K. L. Willett and K. L. , N. B. Perry B. , N. and S. Villa-Trevino and S. 2 2 3 B. L. Upham , B. 1 - BREAST TUMORS IN MICE: ROLE ROLE TUMORS IN MICE: α- BREAST R. C. Smart
LSBI, Mississippi State University, Mississippi LSBI, Mississippi State University, Pharmacology & Toxicology, Univeristy of Otago, of Univeristy Toxicology, & Pharmacology Michigan and Human Development, Pediatrics for Crop and Food Reserach Ltd., Dunedin, New Reserach Ltd., Dunedin, New for Crop and Food and Pathology, Columbia University, College of College University, Columbia and Pathology, York. New and Surgeons, Physicians Martinez Mexico, D.F., City, Mexico CINVESTAV-IPN, Dunedin, New Zealand and Dunedin, New Lansing, MI and State University Y. Nakamura Y. University of Mississippi, University, MS and of Mississippi, University, University 2 State, MS. OF ER L. Larsen 1 Zealand. OF DIFFERENTIATION AUGMENTATION AND GAP JUNCTION FUNCTION IN PARTIALLY BY KAEMPFEROL CELLS. COLON CANCER DIFFERENTIATED Ohtsuki 2 Japan. POSSIBLE MECHANISM OF ACID OF CAFFEIC CHEMOPROTECTION IN PHENETYL ESTER ON INICIATION O. ASSAY. A HEPATOCARCINOGENESIS Beltran-Ramirez E. A. Thompson A. RESPONSE. E. and Raleigh, NC and AND OF EGCG THE COMBINATION GROWTH THE SUPPRESSES TAMOXIFEN Japan, Kyoto, Pref. University Science, Kyoto Research Center, Nara Medical University Nara, Nara Medical University Research Center, OF TAMOXIFEN-MEDIATED CHANGES IN TAMOXIFEN-MEDIATED OF OF EGCG. E. C. Stuart THE METABOLISM THE INDUCTION OF CCAAT/ ENHANCER CCAAT/ THE INDUCTION OF ALPHA IN HUMAN BINDING PROTEIN UVB EXPOSURE EPIDERMIS FOLLOWING THIS ARSENIC ON EFFECT OF THE AND Toxicology, North Carolina State University, North Carolina State University, Toxicology, de Alimentos de Origen Animal, CIAD, AC, AC, Animal, CIAD, Alimentos de Origen de Hermosillo, Sonora, Mexico. IN MECHANISTIC 2D GEL PROTEOMICS OF CHEMOPREVENTATIVE ANALYSIS AND BENZO(A)PYRENE IN FLAVONOIDS CANCER CELL. PROSTATE M. J. Scandlyn M. J. Biology Department, CINVESTAV-IPN, Mexico Mexico Department, CINVESTAV-IPN, Biology and Mexico D.F., City, Pechan T.
(Continued) Annual Annual th Monday, March 6 March Monday, #61 9:48 #62 10:06 9:30 AM to 12:00 NOON 9:30 Room 7A OF CARCINOGENESIS MODULATION SESSION: PLATFORM COMPOUNDS POLYPHENOLIC OCCURING BY NATURALLY East Lansing, State University, Michigan Trosko, James Chairperson(s): MI. #60 9:30 #59 11:36 #63 10:24 45 64 Meeting & ToxExpo & Meeting , , . 3 1 U.S. U.S. 1
2 A. . 1 CIIT , , 2 1 1 LCC, 1 School , M. M. Ema . 3 1 1 Y. Chen , Y. University University Division Division , G. Woo , G. , H. 1 4 1 1 4 . 1 B. A. , B. B. , B. 1 , A. Weston A. , ODC Mouse 1, 2 3 3 , G. Knapp 1 St. Marianna 5 D. Delker and D. D. Delker D. , W. Fahl W. , 1 J. Pi J. D. Geter , D. 2 , K. Inoue 1 U.S. EPA, Durham, Durham, EPA, U.S. 1 1 . 1 , T. Musafia-Jeknic T. , 2 , W. Ward W. , , R. Bildfell , Y. Bai Y. , 1 and M. Hirose M. P. Waalkes and M. P. 1 L. A. Courter L. 1 2 2 , R. Owen 2 , B. Roop , B. 2 Environmental and Molecular Environmental 1 . 1 J. Liu , J. CIIT Centers for Health Research, CIIT Centers for Health 1 2 , C. Keshava S. Collins , J. Kanno , J. 1 and K. Kitchin Division Mol. Toxicol., National Institute Toxicol., Mol. Division SAIC, NCI, Frederick, MD, MD, SAIC, NCI, Frederick, 2 , E. Brooks 3 , J. Rubis , J. , 2 3 3 1 5 and S. Plummer. CXR C. Elcombe and S. Plummer.
, W. Welsh W. , 2 W. Qu , W. 3 UMDNJ, Piscataway, NJ and Piscataway, UMDNJ, National Institute for Occupational Safety 2 2 K. Fischer Group, Drexel Hill, PA. Group, Drexel GENE BETWEEN CORRELATION AND EXPRESSION IN HUMAN CELLS MICE IN SENCAR TUMOR INITIATION A STANDARDIZED TO ON EXPOSURE COMPLEX MIXTURE DERIVED FROM DIESEL EXHAUST. K. Igarashi Toxicology, Oregon State University, Corvallis, Corvallis, State University, Oregon Toxicology, DeAngelo SKIN CARCINOGENESIS. Japan and (APFO). Biosciences Ltd., Dundee, United Kingdom. SPECIFIC GENE EXPRESSION PROFILING PROCESS TUMOR PROMOTION THE TO CARCINOGENESIS THYROID OF RAT OR INDUCED BY SULFADIMETHOXINE M. Shibutani ACID. KOJIC W. M. Baird and W. OR, Ouyang NC, KIDNEY TOXICOGENOMICS OF CHRONIC OF CHRONIC TOXICOGENOMICS KIDNEY EXPOSURE IN F344 BROMATE POTASSIUM Geter D. MALE RAT. SEQUENTIAL PHOSPHORYLATION BY PHOSPHORYLATION SEQUENTIAL CK2 REGULATES KINASE PROTEIN AND DEGRADATION: ACTIVATION NRF2 ARSENIC-INDUCED IN ROLE POTENTIAL Diwan Yamauchi Pathol., National Institute Health Sciences., Tokyo, Tokyo, National Institute Health Sciences., Pathol., NCI at NIEHS, Research Triangle Park, NC, Park, Triangle NCI at NIEHS, Research Health Sciences., Tokyo, Japan. Sponsor: Tokyo, Health Sciences., and Health, CDC, Morgantown, WV and and Health, CDC, Morgantown, T. O’Brien T. Centers for Health Research, Research Triangle Triangle Centers for Health Research, Research NC, Park, Environmental Protection Agency, Research Triangle Triangle Research Agency, Protection Environmental NC and Park, Research Triangle Park, NC. Park, Triangle Research OF PROFILING GENE EXPRESSION AND PAPILLOMAS MOUSE SKIN TO EXPOSURE CHRONIC FOLLOWING IN K6/ ACID MONOMETHYLARSONOUS MICE. TRANSGENIC ODC University School of Medicine, Kawasaki, Japan. School of Medicine, Kawasaki, University of Veterinary Medicine, Oregon State University, State University, Oregon Medicine, Veterinary of OR. Corvallis, OF GENE EXPRESSION COMPARISON OF RATS CHANGES IN PANCREAS WYETH 14, FED DIETS CONTAINING OR DIETHYLHEXYLPHTHALATE 643, AMMONIUM PERFLUOROOCTANOATE Mahadevan of Wisconsin, Madison, WI and Madison, Wisconsin, of 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#55 10:24 #57 11:00 #53 9:48
#58 11:18 Program Description Description Program #54 10:06 #56 10:42
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #64 10:42 BIFUNCTIONAL EFFECT OF #69 PHYSIOLOGICALLY BASED RESVERATROL ON THE EXPRESSION OF PHARMACOKINETIC/ ERBB2 IN HUMAN BREAST CANCER CELL. PHARMACODYNAMIC (PBPK/PD) J. Yang and K. Kang. College of Pharmacy, Chosun SIMULATION OF LOW LEVEL GB University, Gwangju, South Korea. Sponsor: H. EXPOSURE ACROSS MULTIPLE SPECIES. Jeong. J. Gearhart1, 5, P. Robinson1, 5, E. Jakubowski2, R. Mioduszewski2, S. Thomson2, R. Genovese3, #65 11:00 MECHANISM OF TEA CATECHIN AND C. Willmore3, A. Saxena3 and G. Rockwood4. CAFFEINE IN INHIBITION OF LUNG 1Alion Science and Technology, Dayton, OH, 2US TUMOR PROGRESSION INDUCED BY Army ECBC, APG-EA, Aberdeen Proving Grd., 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)- MD, 3WRAIR, Silver Spring, MD, 4USAMRICD, 1-BUTANONE (NNK) IN A/J MOUSE. G. Lu and Aberdeen Proving Grd., MD and 5AFRL/HEPB, C. S. Yang. Rutgers University, Piscataway, NJ. Wright-Patterson AFB, OH. #66 11:18 INHIBITION OF GAP JUNCTIONAL #70 A COMPARISON OF THE CYCLOSARIN AND INTERCELLULAR COMMUNICATION SARIN FLUORIDE ION REGENERATION BY PHOSPHOLIPID METABOLITES RESULTS FROM MINIPIG BLOOD AND AND PROTECTION BY THE RED WINE TISSUE FOLLOWING WHOLE BODY VAPOR, ANTIOXIDANT, RESVERATROL. B. L. Upham, INTRAVENOUS, OR SUBCUTANEOUS J. E. Trosko and L. Blaha. Pediatrics/Human EXPOSURES. E. M. Jakubowski1, J. M. McGuire1, Development, Michigan State University, East R. A. Evans2, S. W. Hulet1, J. A. Renner2, A. L. Lansing, MI. Totura2, T. T. Belski2, W. T. Muse1, D. B. Miller1, R. 1 1 1 #67 11:36 INDUCTION OF DIFFERENTIATION BY J. Mioduszewski and S. A. Thomson . Toxicology KAEMPFEROL IN COLON CANCER CELLS Team, Edgewood Chemical Biological Center, APG- 2 WITH DIFFERENT DIFFERENTIATION Edgewood, MD and Geo-Centers, Edgewood, MD. 1 1 1 PROFILES. Y. Nakayama , Y. Nakamura , K. Sato , #71 A COMPARATIVE STUDY OF THE BINDING 2 2 2 1 C. Chang , B. L. Upham and J. E. Trosko . Food CHARACTERISTICS OF SARIN IN BLOOD Science, Kyoto Pref. University Kyoto, Japan and ACROSS VARIOUS ANIMAL MODELS. J. 2 Pediatrics and Human Development, Michigan McGuire1, E. M. Jakubowski1, R. A. Evans2, R. State University Lansing, MI. J. Mioduszewski1 and S. A. Thomson1. 1US Army ECBC, Aberdeen Proving Ground, MD and 2Geo- Monday, March 6 Centers, Inc., Aberdeen Proving Ground, MD. MONDAY 9:30 AM to 12:00 NOON #72 MEDIAN EFFECTIVE DOSAGES FOR Exhibit Hall MIOSIS (ECT50) AND LETHALITY (LCT50) IN GOTTINGEN MINIPIGS FOLLOWING POSTER SESSION: CHEMICAL-BIOLOGICAL WEAPONS I 10, 60 AND 180-MINUTE WHOLE-BODY Chairperson(s): Jeff Gearhart, Alion Science and Technology, Dayton, EXPOSURES TO CYCLOSARIN (GF) VAPOR. 1 1 1 OH and Madhusoodana Nambiar, Walter Reed Army Institute of Research, S. W. Hulet , D. R. Sommerville , R. B. Crosier , P. 1 2 1 Silver Spring, MD. A. Dabisch , C. L. Krauthauser , J. A. Scotto , D. B. Miller2, W. T. Muse1, B. J. Benton1, J. R. Jarvis2, R. J. Displayed: 9:30 AM–12:00 NOON Mioduszewski1 and S. A. Thomson1. 1Toxicology, US Army -SBCCOM, Aberdeen Proving Grounds, MD Attended: 9:30 AM–11:00 AM and 2Geo-Centers, Inc., Abingdon, MD. #68 TOXICOKINETICS OF INHALED AND #73 DIFFERENTIAL EFFECTS OF SARIN PARENTERAL SARIN (GB) FOLLOWING VAPOR EXPOSURE ON THE OCULAR AND SINGLE AND MULTIPLE SUB-LETHAL CARDIOVASCULAR SYSTEMS. P. A. Dabisch1, EXPOSURES IN THE GUINEA PIG (GP). C. E. Davis1, M. Horsmon2, D. Miller2, J. Scotto1, 1 2 1 E. Whalley , L. A. Lumley , J. M. McGuire , E. R. Mioduszewski1 and S. Thomson1. 1Toxicology, 1 3 2 M. Jakubowski , D. B. Miller , J. H. McDonough , U.S. Army Edgewood Chemical Biological Center, 1 1 R. J. Mioduszewski , S. A. Thomson and T. A. Aberdeen Proving Ground, MD and 2Geo-Centers, 2 1 Shih . ECBC, Aberdeen Proving Ground, MD, Inc., Gunpowder, MD. 2USAMRICD, Aberdeen Proving Ground, MD and 3Geo-Centers, Inc., Aberdeen Proving Ground, MD. #74 EFFECT OF PYRIDOSTIGMINE PRETREATMENT ON SARIN VAPOR- INDUCED MIOSIS. M. Horsmon1, P. Dabisch2, E. Davis2, R. Mioduszewski2 and S. Thomson2. 1Geo-Centers, Gunpowder, MD and 2Toxicology, Universtiy of.S Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD.
up-to-date information at www.toxicology.org 65
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H. Soo Jin Department 1 Pharmacy, Pharmacy, C. Tohyama , C. 1 . 2 1 . Gene Logic Inc., Gene Logic 2 1, 2 M. Niittynen , K. Shiizaki , S. S. Lundback 1 Department of 1 3, 2 Annual Meeting Annual . th Department of , I. D. Moffat , I. D. 2 Department of Food and Department of Food 4 3 Facility of Pharmaceutical Facility 1, 3, 5 2 , K. Takeda , K. 4 Department of Pharmacology, Department of Pharmacology, and H. Jeong Division of Environment Health, of Environment Division 4 1 1, 2 SOT's 45 SOT's . L. D. Burgoon , L. D. 1 3, 1 T. R. Zacharewski and T. . 2 , P. C. Boutros , P. Shin Nippon Biomedical Laboratory, Shin Nippon Biomedical Laboratory, , T. Takahara T. , 3 4 3 , J. Kim , J. Environment Health Sciences. Division, Health Sciences. Division, Environment 3 1, 2 and R. Pohjanvirta 4
Research Center for Proteineous Materials, Chosun , J. Linden , J. and Veterinary National Department of Kuopio, D. R. Boverhof D. of Biochemistry & Molecular Biology and of Biochemistry & Molecular Biology State Michigan Toxicology, Center for Integrative East Lansing, MI and University, Environmental Health, National Public Health Health, National Public Environmental Finland, Institute, Kuopio, University, Kwangju, South Korea. Kwangju, University, Food Research Institute, Kuopio, Finland. Sponsor: Finland. Research Institute, Kuopio, Food Viluksela M. and South Korea Kwangju, Chosun University, 2 Murakami Japan, Japan and Kainan, Japan. HOUSEKEEPING VARIOUS OF EVALUATION APPLICABILITY FOR THEIR GENES FOR EXPRESSION OF mRNA NORMALIZATION RATS. IN DIOXIN-TREATED 2 of Helsinki, Hygiene, University Environmental Helsinki, Finland, 5 EXPRESSION BY CAPSAICIN IN MOUSE CELLS. HEPA-1C1C7 HEPATOMA E. Han COMPARATIVE TOXICOGENOMIC TOXICOGENOMIC COMPARATIVE EFFECTS THE HEPATOTOXIC OF ANALYSIS A. S. Harney AND MICE. TCDD IN RATS OF L. Mendrick The University of Tokyo, Graduate School of Tokyo, of The University Japan, Tokyo, Medicine, Okey TCDD-INDUCED CYP1A1 SUPPRESSION OF Gaithersburg, MD. Gaithersburg, TOXICITIES TCDD STRAIN DIFFERENCE IN HANNOVER WISTAR AND IN LONG-EVANS Kawakami T. GALAS RATS. Sciences., Tokyo University of Sciences., Tokyo, Tokyo, of Sciences., University Tokyo Sciences., National Institute for Environment Studies, Tsukuba, Studies, National Institute for Environment Pharmacology and Toxicology, University of of University Toxicology, and Pharmacology Finland, Kuopio, Kuopio, Canada and ON, Toronto, Toronto, of University and S. Ohsako
(Continued) Annual Annual th #84 Monday, March 6 March Monday, AM to 12:00 NOON 9:30 Exhibit Hall POLLUTANTS PERSISTENT ORGANIC POSTER SESSION: and NC Park, Triangle NIEHS, Research Walker, Chairperson(s): Nigel TX. Health, Dallas, of Public School Texas of University Arnold Schecter, NOON AM–12:00 9:30 Displayed: AM–12:00 NOON Attended: 10:30 #82 #85 #83 45 66
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, 1 , J. , J. , 1 1 1 , , , 2 , R. 1 1 1 S. and M. 3 , J. Forster , J. 1 , J. J. Valdes J. , J. 1 , D. Miller , D. 1 Gene Array Facility, Facility, Array Gene , B. Gaviola , B. Biochemical 3 1 , M. Nau J. W. Sekowski W. J. 1 , R. K. Gordon 2 1 Medical/Analytical Medical/Analytical . 2 2 , S. Martino-Catt 1 Virginia Bioinformatics Virginia 2 , J. Scotto , J. 1 , W. Muse W. , 1 , O. Crasta , O. , M. Horsmon , D. Burnett , D. 2 1 1 A. M. Sciuto , J. R. Graham , J. S. Thomson , S. 1 1, 3 , S. Razani-Boroujerdi, S. Lucas, , S. Razani-Boroujerdi, S. , K. Matson 1 and , B. Benton , B. 2 1 , R. Way , R. 1 Edgewood Chemical Biological Center, Center, Chemical Biological Edgewood 1 , M. Orehek , S. Cammer 1 . 2 3 Medicine, USUHS, Bethesda, MD. U.S. Army, APG-EA, MD, APG-EA, MD, Army, U.S. C. Whalley C. Vahey . Medical Toxicology, U.S. Army Institute Army U.S. Toxicology, I. Baskin. Medical Grounds, Aberdeen Proving for Chemical Defense, MD. Bucher C. L. Crouse K. Lee 3 TO EXPOSURE INHALATION LOW-LEVEL OF KEY ALTERATIONS INDUCES VAPOR VX AND THE BRAIN IN AND PROTEINS GENES BLOOD PLASMA OF RATS. P. E. Rezk FUNCTION IN GUINEA PIGS. P. . Operational Toxicology, ECBC, Toxicology, . Operational Thomson A. and S. MD. Ground, Aberdeen Proving AND TEMPERATURE REDUCED BODY COORDINATION MOTOR IMPAIRED AND ACUTE TO EXPOSED IN RATS VX. OF SUB-LETHAL DOSES REPEATED DEVELOPMENT OF AN HPLC-ESI-MS AN HPLC-ESI-MS DEVELOPMENT OF THE DETERMINATION METHOD FOR PLASMA. IN RAT OF PYRIDOSTIGMINE Army U.S. Toxicology, Analytical Thomson. Abderdeen Center, Chemical Biological Edgewood MD. Ground, Proving OF SARIN DIFFERENTIAL EFFECTS AIRWAY ON GAS EXPOSURE REGIMEN EXPRESSION. CYTOKINE AND REACTIVITY Campen M. J. and M. Sopori. Lovelace Pena-Philippides J. NM. Albuquerque, Respiratory Research Institute, VAPOR VX WHOLE-BODY EFFECTS OF J. B. EXPOSURE ON LETHALITY IN RATS. A. R. Sommerville, P. M. McGuire, D. Benton, J. Mioduszewski R. J. Dabisch, E. M. Jakubowski, Walter Reed Army Institute of Research, Rockville, Army Reed Walter MD. VX: AND GD TO EXPOSURE CUTANEOUS Clarkson, S. M. E. D. ANTIDOTES. TIMING OF and Logan P. T. A. Mendy, S. Railer, Schulz, R. F. M. P. Nambiar M. P. Manthei J. E. Davis, P. Dabisch, R. Mioduszewski and Dabisch, R. Mioduszewski P. E. Davis, Mioduszewski A. Lumley, C. L. Robison, A. R. Kohli, A. Capili, A. R. Kohli, C. L. Robison, A. Lumley, Shih. Pharmacology, and T. Somsamayvong B. MD. Ground, Aberdeen Proving USAMRICD, THE CHEMICAL EFFECTS OF TOXIC VX ON AGENT NERVE WARFARE AND PHYSIOLOGY RESPIRATORY Institute and Polytechnic Virginia Institute, and VA Blacksburg, University, Toxicology, USAMRICD, Edgewood, MD and Edgewood, USAMRICD, Toxicology, T. E. Moran T. Pharmacology, Walter Reed Army Institute of Army Reed Walter Pharmacology, Spring, MD, Research, Silver 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#80 #78 #76 #77 #75
#81 Program Description Description Program #79
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #86 2, 3, 7, 8-TETRACHLORODIBENZO-p- #94 AROCLOR 1254 MAY INDUCE LONG-TERM DIOXIN INCREASES THE EXPRESSION ALTERATIONS IN CENTRAL VASOPRESSIN AND ACTIVATION OF MATRIX RELEASE BY INHIBITING NITRIC OXIDE METALLOPROTEINASE-2 IN HUMAN SYNTHESIS WITHIN THE SUPRAOPTIC FIBROSARCOMA HT1080 CELLS. J. H. Choi1, NUCLEUS. C. G. Coburn1, B. Hou2, L. Lin2, C. 2, J. Y. Kim1, H. G. Kim1, 2, E. H. Han1, 2, Y. P. Cheetham2, E. R. Gillard2, O. Loson2, D. Prodon2 Hwang1, 2, K. N. Oh1, 2 and H. Jeong1, 2. 1Pharmacy, and M. C. Curras-Collazo2, 1. 1Environmental Chosun University, Kwangju, South Korea and Toxicology, UC Riverside, Riverside, CA and 2Cell 2Research Center for Proteineous Materials, Chosun Biology and Neuroscience, UC Riverside, Riverside, University, Kwangju, South Korea. CA. #87 THYROID HORMONE RECEPTOR-α IS #95 HEPATIC GENE EXPRESSION PROFILING NOT RESPONSIBLE FOR TCDD-MEDIATED OF FEMALE RATS CHRONICALLY IMMUNOTOXICITY AND WASTING EXPOSED TO PCB 126, PCB 153, OR A SYNDROME. C. P. Curran, T. P. Dalton, M. BINARY MIXTURE OF PCB 126 AND PCB 153. L. Miller, G. D. Leikauf and D. W. Nebert. K. M. Kransler1, B. J. Ovando1, R. J. Foxenberg1, Environmental Health, University of Cincinnati, C. M. Vezina2 and J. R. Olson1. 1Pharmacology & Cincinnati, OH. Toxicology, SUNY at Buffalo, Buffalo, NY and 2Pharmacy, University of Wisconsin, Madison, WI. #88 EFFECTS ON BONE TISSUE IN MALE AND FEMALE TRANSGENIC MICE EXPRESSING #96 STRUCTURE ACTIVITY ANALYSIS OF A CONSTITUTIVELY ACTIVE ARYL THE INHIBITION OF ALKOXYRESORUFIN HYDROCARBON RECEPTOR. C. I. Wejheden1, O-DEALKYLATION ACTIVITIES BY S. Brunnberg1, A. Hanberg1, C. Ohlsson2 and M. TETRACHLOROBIPHENYLS. P. Edwards and P. Lind1. 1Institute of Environmental Medicine, S. Bandiera. Faculty of Pharmaceutical Sciences, Karolinska Institutet, Stockholm, Sweden and University of British Columbia, Vancouver, BC, 2Department of Internal Medicine, Gothenburg Canada. University, Gothenburg, Sweden. #97 REGULATION OF CYCLOOXYGENASE-2 #89 SHORT-TIME EXPOSURE TO DIOXIN IN GRANULOCYTIC HL-60 CELLS BY 2, 2´, IMPAIRS TRABECULAR BONE TISSUE 4, 4´-TETRACHLOROBIPHENYL INVOLVES IN MALE SPRAGUE/DAWLEY RATS. R. TRANSCRIPTIONAL CHANGES AND Lundberg1, C. Wejheden1, F. Moncek2, A. Rannug2 CHANGES IN mRNA STABILITY. S. Bezdecny1,
and M. Lind1. 1Division of Biochemical Toxicology, 2, 3, R. A. Roth1, 2, 3 and P. E. Ganey1, 2, 3. 1Department MONDAY Institute of Environmental Medicine, Karolinska of Pharmacology and Toxicology, Michigan Institutet, Stockholm, Sweden and 2Division of Work State University, East Lansing, MI, 2Center for Environment Toxicology, Institute of Environmental Integrative Toxicology, Michigan State University, Medicine, Karolinska Institutet, Stockholm, Sweden. East Lansing, MI and 3National Food Safety and Toxicology Center, Michigan State University, East #90 DIOXIN LEVELS IN VIETNAMESE Lansing, MI. POTENTIALLY EXPOSED TO AGENT ORANGE: UPDATE 2006. O. Paepke3, A. J. #98 2, 3, 7, 8-TETRACHLOROPHENOTHIAZ Schecter1, H. T. Quynh2, J. D. Constable4 and K. INE: A POTENT ARYL HYDROCARBON Tung1. 1Environmental Sciences, University of Texas RECEPTOR LIGAND. K. W. Fried1, R. M. Bazzi2, School of Public Health, Dallas, TX, 2Institute for D. R. Bell2 and K. K. Rozman1, 3. 1Department Sustainable Agriculture, Hanoi, Viet Nam, 3Eurofin of Pharmacology, Toxicology & Therapeutics, ERGO Research, Hamburg, Germany and 4Harvard University of Kansas Med. Ctr., Kansas City, Medical School, Boston, MA. KS, 2Molecular Toxicology, School of Biology, University of Nottingham, Nottingham, United #91 CAVEOLIN-1 PLAYS A ROLE IN PCB- Kingdom and 3Section of Environmental Toxicology, INDUCED VASCULAR ENDOTHELIAL CELL Institute for Toxicology, GSF-National Research INFLAMMATION. Z. Majkova, X. Arzuaga, Center for Environment and Health, Neuherberg, E. Lim, E. Smart, M. Toborek and B. Hennig. Germany. University of Kentucky, Lexington, KY. #99 DO THE EPIDERMAL TISSUES OF #92 INDUCTION OF OXIDATIVE STRESS, HUMANS PROVIDE A SUBSTANTIAL DNA DAMAGE, AND CELL TOXICITY BY SINK AND EXCRETION PATHWAY FOR POLYCHLORINATED BIPHENOLS (PCBs) MORE PERSISTENT POLYCHLORINATED IN HUMAN BREAST CANCER CELLS. P. Lin, BIPHENYLS AND DIOXINS? B. D. Kerger1 C. Huang and C. Lin. Environmental Engineering, and R. C. James2. 1HSRI, Inc., Tallahassee, FL and National Chung Hsing University, Taichung, Taiwan. 2TERRA, Tallahassee, FL. #93 POLYCHLORINATED BIPHENYLS (PCBs) #100 DISPOSITION OF A MIXTURE OF MODULATE THE INDUCTION OF CELL POLYBROMINATED DIPHENYL ETHERS TOXICITY, ROS FORMATION, AND DNA (PBDES) IN MALE F344 RATS. E. H. Lebetkin, J. DAMAGE BY 17β-ESTRADIOL IN HUMAN M. Sanders, L. Chen, A. C. Creech and L. T. Burka. BREAST CARCINOMA CELLS. C. Lin, Y. Chou LPC, NIEHS, Research Triangle Park, NC. and P. Lin. Environmental Engineering, National Chung Hsing University, Taichung, Taiwan. up-to-date information at www.toxicology.org 67 , J. , J. 4 , , 5 1 , M. 3 Shimizu . 4 M. C. , K. Office 1
1 , S. Camacho . Facultad de Facultad 1 , M. Guerrero- 1 1 . 1 , S. Uehara 4 Health and 1 , A. Torres-Vega A. , Annual Meeting Annual 4 . S. Knadle 1 , K. Harada th 1 , R. A. , R. Aposhian V. H. Tohoku Kosai Hospital, Kosai Tohoku 5 and R. Schlag 2 , T. Shimizu T. , 3 , E. Zermeno-Gonzalez , C. D. Sherman, M. S. Sandy, C. D. ISSSTE, Torreon, Coahuila, Coahuila, Torreon, ISSSTE, 2
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2 SOT's 45 SOT's . Office of Environmental L. Zeise. Office of Environmental , M. Rubio-Andrade 2 Programa Metales, SSA, Torreon, Torreon, Metales, SSA, Programa and A. Koizumi 4 6 , V. Lujan-Galvan V. , and , J. Garcha , J. 3 2 , M. Kono Facultad de Medicina, UAC, Torreon, Torreon, de Medicina, UAC, Facultad 2 G. G. Garcia-Vargas G. and G. 2 1 Takayama Red Cross Hospital, Takayama, Takayama, Red Cross Hospital, Takayama Japan, Hospital, Hokkaido, Kono 2 3
Coahuila, Mexico. VARIABILITY CHEMICAL-DEPENDENT TO LIFE SENSITIVITY IN EARLY Takenaka Medicina, Investigacion, Universidad Juarez del Universidad Medicina, Investigacion, Durango, Estado de Durango, Gómez Palacio, Mexico, Tomar R. S. of Environmental Health Hazard Assessment, Health Hazard of Environmental Agency, Protection California Environmental CA and Oakland, and M. D. of. K. Chowdhury Zakharyan, Universtiy Department, Molecular and Cellular Biology Avram. AZ. Tucson, Arizona, of University Hernandez-Serrano Coahuila, Mexico, Coahuila, Mexico, CARCINOGENS. IDENTIFICATION OF CHEMICALS OF CHEMICALS IDENTIFICATION SURFACES RELEASED BY PLAYGROUND Vidair TIRES. C. MADE OF RECYCLED Chan, SCHOOL SITES. D. USING DIFFERENTIAL IN-GEL ELECTROPHORESIS. LEAD EXPOSURE IN NEWBORN CHILDREN COMMUNITY A SMELTER LIVING IN MEXICO. IN REGION LAGUNERA, De la Rosa Garcia-Salcedo Almeida OCTANOL-WATER PARTITION PARTITION OCTANOL-WATER THE PREDICT COEFFICIENTS CAN TO SERUM OF POPS FROM PARTITION BREAST MILK. Japan, Japan, Sendai, Japan and Health Hazard Assessment, Oakland, CA. Assessment, Oakland, Health Hazard Environmental Sciences, Kyoto University, Kyoto, Kyoto, University, Sciences, Kyoto Environmental T. Takasuga T. and D. Siegel. Cal/EPA, OEHHA, Sacramento, CA. Cal/EPA, Siegel. and D. SEARCH FOR PLASMA PROTEIN AUTISM BIOMARKER FOR Research, Inc., Kyoto, Japan. Research, Inc., Kyoto, CHILD-SPECIFIC REFERENCE VALUES TO TO VALUES CHILD-SPECIFIC REFERENCE CALIFORNIA AT RISK ASSESS HEALTH Hospital, Hyogo, Japan, Hospital, Hyogo, Protection Control, California Environmental CA. Sponsor: R. Howd Berkeley, Agency, Mexico and Mexico M. Petreas
(Continued) Annual Annual th #113 #112 9:30 AM–11:00 AM AM–11:00 Attended: 9:30 #109 #108 AM to 12:00 NOON 9:30 Exhibit Hall AND JUVENILE CHILDREN’S HEALTH POSTER SESSION: TOXICITY ANIMAL OH and Columbus, Children, Smith, Columbus Charles Chairperson(s): Japan. Sapporo, of Medicine, Mingyue School Ma, Hokkaido University AM–12:00 NOON 9:30 Displayed: #111 Monday, March 6 March Monday, #110 45 68
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2 , , , 3 3 , . 2, 3 3 1 G. S. S. G. and M. 3 , T. Nakahari T. , 1 E. Matsubara, , I. Hirosawa , K. Harada , H. Nakatsuka 4, 3 , K. Takenaka , K. 2, 3 3 3 National Institute for 4 , T. Watanabe T. , 3 J. Olivero-Verbel and J. , K. Inoue , M. Kinboshi 2, 1 1 , K. Murata 2, 3 3 , S. Shimbo , N. Hachiya , N. 3 3 Department of Health and 1 . Master’s Degree in Program Master’s 1 Sample Banking Project for POPs 2 3 , H. Todoriki , H. 3 Department of Physiology, Osaka Department of Physiology, 2 , S. Fujii , N. Saito , N. 3 , Y. Kusaka Y. , 2, 3 Environmental and Preventive Medicine, and Preventive Environmental 3 , A. Koizumi 1 E. Matsubara . 1, 3 3 Kyoto University Graduate School of Medicine, University Kyoto Environmental and Computational Chemistry Environmental Environmental Sciences, Kyoto University, Kyoto, Kyoto, University, Sciences, Kyoto Environmental Minamata Disease, Minamata, Japan. S. Inoue K. Omae 2 Japan, Kyoto, Japan and Monitoring, Kyoto, PARAMECIUM CAUDATUM. IN PARAMECIUM . Department K. Harada, K. Inoue and A. Koizumi Sciences, Kyoto of Health and Environmental Japan. Kyoto, University, OF METHYL THE INTAKE ASSESSMENT OF AMONG DIETS THROUGH MERCURY Y. IN JAPAN. GENERAL POPULATION Wada . Department of Health and K. Inoue and A. Koizumi Kyoto, University, Sciences, Kyoto Environmental Japan. RELATIONSHIP ACTIVITY STRUCTURE OF EFFECTS OF PERFLUORINATED SWIMMING AMPHIPHILES ON BACKWARD MICE. and A. Koizumi Japan and 1 of Cartagena, Cartagena, Group, University Colombia and Colombia. SULFONATE PERFLUOROOCTANE ANGLE OF CILIARY THE INCREASES CELLS IN TRACHEAL OF MOVEMENT M. Moreno-Contreras IMMUNOMODULATION BY IMMUNOMODULATION (PFOS) PERFLUOROOCTANESULFONATE FEEDING STUDY. RAT A 28-DAY IN Armstrong, M. C. Bondy, I. Curran, L. Coady, Shenton. and J. Liston, L. Hierlihy V. Parenteau, Directorate, Food Research Division, Toxicology Canada. ON, Health Canada, Ottawa, (PFOS) PERFLUOROOCTANESULFONATE FEEDING A 28-DAY RAT: THE IN TOXICITY Liston, L. Hierlihy, V. I. Curran, Bondy, G. STUDY. Research Toxicology L. Coady and S. Gurofsky. Directorate, Health Canada, Ottawa, Food Division, Canada. ON, ACID SULFONIC PERFLUOROOCTANE FUNCTION. HUMAN NEUTROPHIL ALTERS T. Takeshita T. S. Koda Hyogo College of Medicine, Nishinomiya, Japan, College Hyogo Medical College, Takatsuki, Japan. Takatsuki, Medical College, ADMINISTERED CENTRALLY (PFOS) SULFONATE PERFLUOROOCTANE A. IN MICE. DECREASES FOOD INTAKE M. Kinboshi, K. Harada, E. Matsubara, Asakawa, Microbiology, University of Cartagena, Cartagena, University Microbiology, Ikeda 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #114 AGE RELATED DIFFERENCES IN #122 META-ANALYSIS ON CANCER SENSITIVITY SECONDARY MALIGNANCIES IN DUE TO AGE AT EXPOSURE TO DIRECT CHILDREN: LESSONS LEARNED FROM ACTING ETHYLNITROSOUREA. R. S. Tomar, THE PEDIATRIC CLINICAL EXPERIENCE. M. S. Sandy, C. D. Sherman and L. Zeise. OEHHA, D. Pyatt1, 2 and S. Hays1. 1Summit Toxicology, California EPA, Oakland, CA. Lafayette, CO and 2MTEHS, University of Colorado, Denver, CO. #123 OXIDANT RESPONSES IN LPS-INDUCED PRETERM BIRTH IN MICE. C. V. Smith, K. #115 ANALYSIS OF THE SPATIAL PROXIMITY M. Heyob, F. A. Jenniskens, S. E. Welty and L. K. OF CHILDHOOD LEUKEMIA TO HIGH Rogers. Pediatrics, Columbus Children’s Research DENSITY ROADS IN UTAH. S. LeFevre and W. Institute, Columbus, OH. Ball. Environmental Epidemiology Program, Utah Department of Health, Salt Lake City, UT. #124 EVALUATION OF THE AGE-DEPENDENT NEPHROTOXICITY OF GENTAMICIN #116 IMPLICATIONS OF CHILDHOOD ACUTE USING GENE EXPRESSION BIOMARKERS. LYMPHOCYTIC LEUKEMIA STUDIES FOR B. A. Rosenzweig, K. Thompson, J. Hanig and P. CHILDREN’S HEALTH RISK ASSESSMENT. Espandiari. DAPR, CDER, USFDA, Silver Spring, A. S. Kim. U.S. EPA, Washington, DC. Sponsor: S. MD. Barone. #125 CHARACTERIZATION OF A RODENT #117 PHYSIOLOGICAL DAILY INHALATION PEDIATRIC NEPHROTOXICITY MODEL. RATES FOR FREE-LIVING INDIVIDUALS P. Espandiari1, T. Miller1, J. Zhang1, A. Knapton1, AGED 1 MONTH TO 96 YEARS. P. Brochu1, 2, P. Goering2, R. Brown2, V. Vaidya3, A. Johnson3, J. Ducre-Robitaille1 and J. Brodeur2. 1Ministry of J. Bonventre3, B. Rosenzweig1, K. Thompson1, P. Sustainable Development, Environment and Parks, Pine1, L. Schnackenberg4, R. Beger4, E. Herman1, Quebec Government, Quebec, Canada and 2Faculty J. Weaver1 and J. Hanig1. 1CDER, USFDA, Silver of medicine, University of Montréal, Montréal, QC, Spring, MD, 2CDRH, USFDA, Silver Spring, MD, Canada. 3Renal Division, Harvard Medical School, Boston, MA and 4Division of Systems Toxicology, NCTR, #118 HEAVY METALS IN HUMAN COLOSTRAL Jefferson, AR. BREAST MILK AND MATERNAL SMOKING EFFECTS IN ISTANBUL –TURKEY. H. Gul1, #126 POTENTIAL MODEST PROTECTIVE A. Onen2, G. Gungor1, A. Ozden3, S. Ozel4 and EFFECT OF MIDAZOLAM ON KETAMINE- 5 1
L. Ibrahimoglu . Department of Public Health, INDUCED APOPTOSIS IN RAT FOREBRAIN MONDAY Istanbul Medical Faculty, Istanbul, Turkey, 2Turk CULTURE. N. Sadovova2, X. Zou1, A. Scallet1, Henkel, Reseach&Development, Istanbul, Turkey, T. Patterson1, J. Hanig3, M. Paule1, W. Slikker1 and 3Institute of Child Health, Trace Element Laboratory, C. Wang1. 1Division of Neurotoxicology, NCTR/ Istanbul, Turkey, 4Department of Biostatistics, U.S. FDA, Jeferson, AR, 2Toxicologic Pathology Istanbul Faculty of Medicine, Istanbul, Turkey and Associates, Jefferson, AR and 3CDER/U.S. FDA, 5Department of Obstetrics and Gynecology, Istanbul Rockville, MD. Faculty of Medicine, Istanbul, Turkey. #127 CYTOTOXCITY AND MUTAGENICITY #119 THE EFFECTS OF INHALATION EXPOSURE IN HUMAN TK6 LYMPHOBLASTOID OF DI-2-ETHYLHEXYLPHATHALATE CELLS EXPOSED IN VITRO TO (DEHP) ON THE ONSET OF PUBERTY METHYLPHENIDATE. M. M. Carter, V. E. AND POSTPUBERTAL REPRODUCTIVE Walker, C. L. McCash and D. M. Walker. Cancer, FUNCTIONS IN PREPUBERTAL FEMALE LRRI, Albuquerque, NM. RATS. M. Ma, T. Kondo, T. Umemura, N. Kurahashi and R. Kishi. Department of Public Health, Monday, March 6 HokkaidoUniversity School of Medicine, Sapporo, 9:30 AM to 12:00 NOON Japan. Sponsor: W. Zheng. Exhibit Hall #120 EFFECT OF PHENOBARBITAL ON SERUM TESTOSTERONE CONCENTRATION IN POSTER SESSION: DEVELOPMENTAL TOXICITY IN IN VIVO JUVENILE RATS. R. Itamura, Y. Asaoka, M. AND IN VITRO SYSTEMS Horimoto and I. Horii. Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Chairperson(s): Janice Lansita, Biogen Idec, Cambridge, MA and Stacey Laboratories, Pfizer Inc., Aichi, Japan. Sponsor: M. Harper, Oregon State University, Corvallis, OR. Kurata. Displayed: 9:30 AM–12:00 NOON #121 THE EFFECT OF ENVIRONMENTAL TOBACCO SMOKE ON LYMPHOCYTE Attended: 10:30 AM–12:00 NOON INFILTRATION IN THE LUNG. A. Ross and #128 HUMAN DIETARY ALKALOIDS INHIBIT J. Peake. Center for Health & the Environment, HEDGEHOG SIGNALING. R. J. Lipinski, E. University of California, Davis, Davis, CA. Sponsor: K. Dengler, W. Heideman, R. E. Peterson and W. K. Pinkerton. Bushman. Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI. up-to-date information at www.toxicology.org 69 , 3 , M. 1 . , A. , 2 K. 2 . , T. T. , , T. A. T. , 1 , and 1 1, 2 2 , 1, 4 3 . , A. , 3 2 and K. K. 3, 4 , L. C. Pinn Curriculum in , S. Bongiovanni 2 , K. Becker and A. Seiler and 4 1, 2 2 2 Nicholas School of M. Chisato Virginia Tech, Tech, Virginia 3 D. Hinton , D. 2 E. A. Myers E. Curr. in Toxicol., Toxicol., in Curr. , A. E. Tanner A. E. , NTD, U.S. EPA, EPA, U.S. NTD, Annual Meeting Annual 2, 1 2 2 Safely ProfilingSafely 1 M. F. DeCristofaro M. F. 4 th . and , E. Genschow 2 F. Staedtler and F. 1, 2 1, 2 2 , S. E. Parnell , A. Cordier , 3, 4 3 M. R. Prater Safely ProfilingAssessment, Safely and 2 , K. Schlechter , H. Spielmann Graduate School of Medicine, Virginia College of Osteopathic of Osteopathic College Virginia 2 1 2 1 SOT's 45 SOT's . , R. Buesen National Center for Documentation 2 1 Bowles Center for Alcohol Studies, Alcohol Studies, Center for Bowles 2 4 , D. Beckman , D. M. Yoshiharu , M. and S. Padilla 3 Department of Cell and Developmental Department of Cell and Developmental 1 3 Curriculum in Toxicology, University of University Toxicology, Curriculum in , C. L. Laudermilch 1, 2 1 2 , M. Letzkus , D. B. Dehart B. , D. 2 . . , B. Slawik , B. 2 2, 4 3, 4 Experimental Toxicology, Schering AG, Berlin, AG, Schering Toxicology, Experimental Graduate School of Medicine, Chiba University, Graduate School of Medicine, Chiba University, Pharmaceuticals, Novartis Development, Biomarker Pharma Novartis Development, Biomarker Steger-Hartmann North Carolina, Chapel Hill, NC, and Germany Department of Bioenvironmental Medicine, CHIBA- Medicine, DepartmentBioenvironmental of Japan and KEN, NJ, East Hanover, Basel, Switzerland and AG, Kaltenhaeuser 1 Sulik Hill, NC, Hill, NC and 1 O’Hara S. Chibout 1 NJ, Pharmaceuticals, East Hanover, Novartis 3 Switzerland. PREDICTIVE MOLECULAR ESTABLISHING AS MARKERS OF DIFFERENTIATION THE ENDPOINTS IN TOXICOLOGICAL TEST (EST). J. STEM CELL EMBRYONIC MOUSE MODEL. E. Flood Holladay S. D. OF HEIGHTENED ASSESSING PERIODS S. Oxendine SENSITIVITY. UNC-CH, Chapel Hill, NC and Durham, NC. University, Duke the Environment, EFFECTS OF ETHANOL TERATOGENIC HEM. THE CORTICAL ON Riecke CHARACTERIZING THE ROLE OF THE ROLE CHARACTERIZING IN ANTIOXIDANTS DIETARY MATERNAL AND PLACENTAL IMMUNE REGULATION THE DEVELOPMENT IN LIMB AND DISTAL VA. Blacksburg, A MODEL FOR AS FISH MEDAKA TOXICITY: ETHANOL DEVELOPMENTAL NC, Park, Triangle Research Visan Neurobiology, University of North of Carolina, Chapel University Neurobiology, Science Health Environmental Chiba University, Japan. Project for Future Generations, CHIBA-KEN, ACID VALPROIC OF INVESTIGATION 9 DAY THE GESTATION IN TOXICITY AN INTEGRATED MOUSE FETUS USING APPROACH. GENOMICS J. Cowden J. and Evaluation of Alternative Methods to Animal Methods to Alternative of and Evaluation Institute for Risk Experiments (ZEBET), Federal Sponsor: Assessment (BfR), Berlin, Germany. University of North Carolina, Chapel Hill, NC. University BEING BORN EFFECT ON F1 GENERATION WITH RETINOIC TREATED MICE FROM Makoto N. DURING GESTATION. ACID Basel, AG, Pharma Assessment, Novartis and Medicine, Blacksburg, VA and and VA Medicine, Blacksburg, F. Hideki F. Biology, University of North Carolina, Chapel University Biology, Wills
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1 M. 4 J. A. J. . 2 Covance Covance 4 , O. Laskin , O. and 2 , A. Arima A. , 1 Shin Nippon , D. Hutto , D. 1 2 Covance Covance 2 ORD/NHEERL/ , A. Vu A. , 3 2 3 C. Gasper and K. Meyer , D. P. Sponenberg P. , D. 1 1 , K. Fukunishi Toxicology, UNC Toxicology, 1 Virginia College College Virginia via 1 . Celgene Corporation, S. Teo , S. and M. R. Prater 2 2 1 AN VERSUS L. Latriano 1
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, J. Tibbitts , J. J. Rutkowski , J. 1 , I. Osterburg 1 1 Sanofi-Aventis, Malvern, PA. Sanofi-Aventis, 2 Charles River Laboratories Charles River 3 S. D. Holladay , S. D. , D. L. Ward L. , D. Biogen Idec, Cambridge, MA, Idec, Cambridge, MA, Biogen 1 M. Christian 1 1
. 1 , A. Hirose , 1 , D. Stirling , D. ExxonMobil Biomedical Sciences, Inc., ExxonMobil Biomedical Risk Assessment, National Institute of Assessment, National Risk 3 , C. Graff , R. Hawks 1 and R. Smialowicz 1 1 2 2 Discovery and Development Services, and Development Discovery . . 2 , C. Tenhoor , C. 2 2 1 DBSP, Virginia-Maryland Regional College College Regional Virginia-Maryland DBSP, 1 Biomedical Sciences, Edward Biomedical Sciences, Edward . Preclinical Research, XOMA (US) LLC, Berkeley, Preclinical Research, XOMA (US) LLC, Berkeley, Preclinical Pharmacology and Toxicology, Predix Toxicology, and Preclinical Pharmacology of Veterinary Medicine, Blacksburg, VA and VA Medicine, Blacksburg, Veterinary of V. Sharper V. C. Laudermilch Health Sciences, Tokyo, Japan and Tokyo, Health Sciences, T. Ihara T. Williams G. K. Saunders 1 2 Chapel Hill, Chapel Hill, NC and 1 CA and EXPOSURE MORE SENSITIVE? K. Goff International, Horsham, PA, International, Horsham, PA, IN RABBITS. Summit, NJ and Lansita Clarke and J. 2 Pharmaceuticals, MA, Lexington, Matsumoto Ltd., Kagoshima, Japan. Biomedical Laboratories, THE MINIPIG IN DEVELOPMENTAL A. Kledal and T. A. Makin, STUDIES. TOXICITY Scantox and Pharmacology, Toxicology Christensen. Denmark. Sponsor: R. Harling A/S, Lille Skensved, DEVELOPMENTAL TOXICITY OF TOXICITY DEVELOPMENTAL APPLIED ESTERS PENTAERYTHRITOL IN RATS. DERMALLY GIVEN DURING CYNOMOLGUS MONKEYS ORGANOGENESIS. REPRODUCTION DEVELOPMENTAL ALEFACEPT. OF STUDY TOXICITY of Osteopathic Medicine, Blacksburg, VA. of Osteopathic Medicine, Blacksburg, Thorsrud Feuston IN OF DIBUTYLTIN STUDY TERATOLOGY ETD/ITB, University of S. EPA, Research Triangle Triangle Research of S. EPA, University ETD/ITB, NC. Park, DEFECT OF BIRTH COMPARISON NON-SPECIFIC TO REDUCTION DUE WITH IFN- IMMUNE STIMULATION AND CD-1 GAMMA IN C57BL/6N MICE. METHYLNITROSOUREA-EXPOSED ADULT EXPOSURE: IS DEVELOPMENTAL IS DEVELOPMENTAL EXPOSURE: ADULT Charles River Laboratories, Spencerville, OH. Charles River IN IMMUNOTOXICITY COMPARING AFTER IN UTERO RATS Laboratories, Chantilly, VA. Laboratories, Chantilly, THE DEVELOPMENTAL OF EVALUATION OF LENALIDOMIDE POTENTIAL TOXICITY V. Palmer V. Preclinical Services, Horsham, PA. ANTIMICROBIAL A NOVEL XMP.629, TREATMENT THE PEPTIDOMIMETIC FOR ACNE MODERATE TO OF MILD OF POTENTIAL EVALUATION VULGARIS: EFFECTS OF XMP.629 DEVELOPMENTAL AND NEW RATS IN SPRAGUE-DAWLEY WHITE RABBITS. ZEALAND Laboratories, Muenster, Germany and Germany Laboratories, Muenster, Paulsboro, NJ and Paulsboro, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#130 Program Description Description Program #136 #135 #133 #134
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #143 ENVIRONMENTALLY-RELEVANT #151 MATRIX METALLOPROTEINASE TRICHLOROETHYLENE EXPOSURE EXPRESSION AND FUNCTION DURING ALTERS CARDIAC HEMODYNAMICS ZEBRAFISH EMBRYOGENESIS: DURING AviaN DEVELOPMENT. V. J. Drake1, ANALYSIS OF MMP-2, MMP-9, AND J. Lough2, N. Hu3, 4 and S. M. Smith1. 1Department MMP-13 FOLLOWING EXPOSURE TO of Nutritional Sciences, University of Wisconsin- DEXAMETHASONE OR HYDROCORTISONE. Madison, Madison, WI, 2Department of Cell J. M. Hillegass, C. M. Villano, L. A. White and K. Biology, Anatomy and Neurobiology, Medical R. Cooper. Joint Graduate Program in Toxicology, College of Wisconsin, Milwaukee, WI, 3Department Rutgers, The State University of New Jersey, of Pediatrics, University of Utah, Salt Lake City, UT Piscataway, NJ. and 4Primary Childrens Medical Center, Salt Lake City, UT. Sponsor: R. Hines. #152 DISCORDANT PHENOTYPES OF GENETICALLY DIVERGENT #144 EXAMINATION OF THE CRITICAL WINDOW ZEBRAFISH EXPOSED TO 3, 3’, 4, 4’, 5- FOR LOW DOSE TRICHLOROETHYLENE PENTACHLOROBIPHENYL (PCB126). E. EXPOSURE TO CHICK EMBRYOS. E. S. Waits. U.S. EPA, Cincinnati, OH. Sponsor: T. Reddy. Rufer1, V. Drake1, J. Lough2 and S. M. Smith1. 1Nutritional Sciences, University of Wisconsin #153 COMPARISON OF THE EFFECTS OF 3 - Madison, Madison, WI and 2Medical College of PLANT ALKALOIDS ON THE DEVELOPING Wisconsin, Milwaukee, WI. Sponsor: C. Jefcoate. CHICK EMBRYO AND FRUIT FLY LARVAE. K. Lustofin and B. Francis. Entomology, University #145 ASSESSING THE TOXIC POTENTIAL OF of Illinois at Urbana-Champaign, Urbana, IL. ACUTE EXPOSURE TO ENGINEERED NANOMATERIALS. S. L. Harper and R. L. #154 CATALASE SIGNIFICANTLY PROTECTS Tanguay. Environmental and Molecular Toxicology, AGAINST VALPROIC ACID INDUCED Oregon State University, Corvallis, OR. NEURAL TUBE DEFECTS IN CD-1 MOUSE EMBRYOS IN CULTURE. E. W. Tung1 and L. M. #146 EFFECT OF 8-MOP ON DEVELOPMENT OF Winn1, 2. 1Pharmacology and Toxicology, Queen’s FROG EMBRYO. C. L. Osborne, J. Cozzetta and University, Kingston, ON, Canada and 2School M. M. Diawara. Biology, Colorado State University- of Environmental Studies, Queen’s University, Pueblo, Pueblo, CO. Kingston, ON, Canada. #147 CELL DEATH AND HSP70/EGFP #155 EFFECTS OF TCDD ON MOUSE
EXPRESSION IN THE DEVELOPING EMBRYONIC STEM CELLS IN CULTURE. MONDAY OLFACTORY SYSTEM OF ZEBRAFISH A. TAKAGI and J. KANNO. Cellular & Molecular LARVAE FOLLOWING CADMIUM Toxicology, National Institute Health Sciences, EXPOSURE. C. J. Matz and P. H. Krone. Anatomy Tokyo, Japan. Sponsor: A. Takagi. and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada. Sponsor: P. Devine. #156 INHIBITION OF MOUSE KIDNEY DEVELOPMENT BY BENZO(A)PYRENE: #148 TOXIC EFFECTS OF LOW LEVELS INVOLVEMENT OF ARYL HYDROCARBON OF DIMETHYL SULFOXIDE DURING RECEPTOR AND WILMS’ TUMOR EMBRYONIC DEVELOPMENT IN MEDAKA SUPPRESSOR GENE. A. Nanez and K. S. Ramos. (ORYZIAS LATIPES). J. Cowden1, S. Oxendine2, Biochemistry and Molecular Biology, University of 1, D. Hinton3 and S. Padilla1, 2. 1Neurotoxicology Louisville, Louisville, KY. Division, U.S. EPA, Research Triangle Park, NC, 2Curriculum in Toxicology, University of Monday, March 6 North Carolina - Chapel Hill, Chapel Hill, NC 9:30 AM to 12:00 NOON and 3Nicholas School of the Environment, Duke Exhibit Hall University, Durham, NC. #149 EXPRESSION OF THE HELIX-LOOP- POSTER SESSION: BIOMARKERS HELIX INHIBITOR OF DNA BINDING-6 (ID-6) GENE IS INDUCED BY ALL-TRANS Chairperson(s): Timothy Fennell, RTI, Research Triangle Park, NC and M. RETINOIC ACID IN ZEBRAFISH EMBRYOS. Firoze Khan, University of Texas Medical Branch, Galveston, TX. 1, 2 1, 2 2, 1 1 C. Villano , J. Hillegass and L. White . Joint Displayed: 9:30 AM–12:00 NOON Graduate Program in Toxicology, Rutgers, The State University of New Jersey, Piscataway, NJ and Attended: 9:30 AM–11:00 AM 2Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, NJ. #157 GENE EXPRESSION ALTERATIONS OBSERVED IN PRIMARY CULTURED RAT #150 ETHANOL PERTURBS ALCOHOL HEPATOCYTES AFTER TREATMENT WITH DEHYDROGENASE ENZYME EXPRESSION CHLORINATED OR CHLORINATED AND IN JAPANESE MEDAKA EMBRYO. A. K. OZONATED DRINKING WATER. L. M. Crosby1, Dasmahapatra1, 2, X. Wang2, 1 and M. L. Haasch1, T. M. Moore2, J. Simmons2 and A. B. DeAngelo2. 2. 1National Center for Natural Product Research, 1U.S. EPA/UNC Coop. Training Progr., Chapel University of Mississippi, University, MS and Hill, NC and 2NHEERL, ORD, U.S. EPA, Research 2Department of Pharmacology, University of Triangle Pk, NC. Mississippi, University, MS. up-to-date information at www.toxicology.org 71
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. M. 2 N. V. V. N. A. , RTI RTI 1 1 and N. and N. Iconix, Mt . 2 , S. 2 2 1 S. C. , 1 Roche, Palo Roche, Palo 4 K. Yu , K. C. A. Afshari A. , C. 2 2 D. G. Robertson G. , D. 1 Annual Meeting Annual G. Dietsch , G. Drug Research Safety 1 th 1 and M. R. Fielden 4 . , A. Soto , 1 2, 3 , R. W. Snyder W. , R. Comparative Biology and Biology Comparative 1 1 , M. Damore 1 Metabonomics Evaluation Metabonomics Evaluation . Charles River Laboratories, Charles River M. A. Friedman and M. 1 R. Eyre 1 2 1 . Chiba University, Chiba, Japan. Chiba University, L. C. Robosky 2 3 , SOT's 45 SOT's 1 , K. L. Kolaja 3 T. Fennell T. Merck, Seattle, WA and WA Merck, Seattle, M. Todd , M. Alion Science & Technology, Dayton, Dayton, Technology, Alion Science & T. Satoh and T. 3 1 1 1 . AFRL, Wright-Patterson AFB, OH. AFB, Wright-Patterson AFRL, 2 , A. R. Stapleton , 2 , J. Burgess , J. 1 HAB Research Laboratories, Ichikawa, HAB Research Laboratories, Ichikawa, 1 2 Medical Sciences, Amgen Inc., Thousand Oaks, Amgen Inc., Medical Sciences, H. K. Hamadeh 2 Preclinical Studies, ICOS, Bothell, WA, WA, Preclinical Studies, ICOS, Bothell, UMDNJ, Newark, NJ. Newark, UMDNJ, PLACENTAL GENE EXPRESSION PLACENTAL HIGH LEVELS OF TO IN RESPONSE IN PLACENTA GENISTEIN UNCONJUGATED ADMINISTERED GENISTEIN. OF RATS ASSOCIATED CHANGES EXPRESSION GENE IN RATS TOXICITY ADRENAL WITH INHIBITORS. VEGFR2 WITH TREATED EXTREMELY SENSITIVE BIOMARKER EXTREMELY ORGANOPHOSPHORUS ACUTE OF International, Research Triangle Park, NC and Park, Triangle International, Research CA. . Division . Division Borghoff and S. J. Parkinson Soucy, H. D. Centers for Health Sciences, CIIT of Biological NC. Park, Triangle Research, Research TRANSCRIPTOME HEPATIC A SELECTIVE PDE4 DIFFERENTIATES A POSSIBLE AND IDENTIFIES INHIBITOR PHASE RESPONSE ACUTE MECHANISM OF LOSS OF INTESTINAL TO (APR) DUE PERMEABILITY. 1 Alto, CA. EXPRESSION OF GENE IDENTIFICATION CHANGES IN PERIPHERAL BLOOD MONONUCLEAR CELLS INDICATIVE WITH CHEMICALS TO OF EXPOSURE TOXICITY. ORGAN TARGET DIFFERENT Chan V. DelRaso OH and A. Higgins and and HUMANS. Sumner 2 Fujikawa Y. INSECTICIDE EXPOSURE. Japan, Chiba, Japan and Wilmington, MA. Wilmington, OF URINARY KINETICS OF ELIMINATION IN ACRYLAMIDE OF METABOLITES Tugendreich METABONOMIC EVALUATION OF EVALUATION METABONOMIC MICROFLORA ALTERED SCHAEDLER Wells D. RATS. Safety Sciences, Amgen Inc., Thousand Oaks, CA Amgen Inc., Safety Sciences, View, CA, View, Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Laboratories, Eisai Co., Ltd., Group, Pfizer Global Research & Development, MI and Arbor, Ann Suganuma and C. C. Clifford
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Icoria, , R. 1 2 Discovery Discovery Systems 2 . 1 , H. Yamada , H. 1 L. D. , L. D. and J. and J. University of University 2 2 . 1 2 , X. Liao 2 , M. Viant , M. 3 1 Environmental Environmental , P. S. Pine , P. , D. Kim , D. R. D. Beger R. D. 1 2 , M. Sanders 2 2 . α 1 , J. T. Pearce T. , J. 1 Graduate School of CDER, USFDA, Silver Silver CDER, USFDA, C. Lin 1 2 , J. Megyesi , J. Systems Toxicology, Toxicology, Systems 1 . , B. Sadri , B. 1 3 , S. Sakemi 2 . 1 2 , J. C. Lindon , J. J. Hanig and J. G. H. Cantor , G. 1 , A. Maki , Analytical Research and Analytical 1 and A. Higgins and 2 1 3 2 M. Coen , V. Roongta V. , . 2 Internal Medicine, University of Internal Medicine, University , P. Espandiari , P. , M. Ford 2 1 1 Biological Chemistry, Imperial Chemistry, Biological , J. Cai , J. 1 2 Worldwide Safety Sciences, PGRD Safety Sciences, Worldwide . 1 and A. Deese and 1 R. Tjeerdema and R. Worldwide Safety Sciences, Pfizer Worldwide 2 , H. Zhang 1 . , E. Holmes 2 2 1 , T. Fukushima T. , , W. W. Collette W. W. , 1 Discovery Technologies, PGRD Nagoya PGRD Nagoya Technologies, Discovery 1 2 and D. Portilla and D. R. D. Beger , R. D. , F. T. Crews T. , F. 2 2 1 1, 2 School of Biosciences, University of School of Biosciences, University 2 I. Rusyn , 1 L. Schnackenberg Development, PfizerDevelopment, Inc., La Jolla, CA. OF CHINOOK ANALYSES METABOLOMIC CRUDE TO EXPOSED SALMON SMOLTS METABOLOMICS STUDY OF CISPLATIN- STUDY METABOLOMICS OF PPAR ROLE FED MICE: Nagoya Laboratories, Pfizer Inc., Taketoyo, Aichi, Laboratories, PfizerTaketoyo, Nagoya Inc., Toxicology, National Center for Toxicological Toxicological National Center for Toxicology, AR and Research, Jefferson, National Center for Toxicological Research, Toxicological National Center for AR and Jefferson, B. Anderson B. Safirstein Sponsor: M. Kurata and I. Horii Japan and Shah TECHNOLOGIES. K. Nicholson OIL OR DISPERSED OIL. Davis, of California, Davis, University Toxicology, CA and Okamoto Inc., La Jolla, CA and METABONOMICS OF A RODENT A RODENT OF METABONOMICS MODEL. NEPHROTOXICITY PEDIATRIC Anderson Public Health, San Diego State University, San University, State Diego Health, San Public CA, Diego, Arkansas for Medical Sciences, Central Arkansas Arkansas for Medical Sciences, Central AR. Healthcare System, Little Rock, Veterans Toxicology, Bristol-Myers Squibb, Lawrenceville, Squibb, Lawrenceville, Bristol-Myers Toxicology, NJ. ALCOHOL OF ANALYSIS METABOLOMIC AND LIVER. BRAIN IN RAT TOXICITY North Carolina, Chapel Hill, NC. OF INVESTIGATION A METABONOMICS INDUCED TOXICITY TESTICULAR THE T. TOXICANTS. BY MALE REPRODUCTIVE Yamamoto Inc., Research Triangle Park, NC and Park, Triangle Inc., Research College, London, United Kingdom and College, Aichi, Japan. Laboratories, PfizerTaketoyo, Inc., Spring, MD. OF INVESTIGATION METABONOMICS IN SPRAGUE- TOXICITY CISPLATIN AND B6C3F1 MOUSE. RAT DAWLEY J. Corbell J. K. Schnackenberg Birmingham, Birmingham, United Kingdom. OF EVALUATION METABONOMIC NECROSIS-INDUCED PAPILLARY RENAL IN BIOFLUIDS ALTERATIONS METABOLIC AND UPLC-MS TISSUES USING NMR AND N. Aranibar N. G. J. Stevens J. G. LehmanMcKeeman H. C. Keun 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#160 #164 #158 #162 #163
#159 Program Description Description Program #161
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #172 QUANTITATIVE ANALYSIS OF DRUG- #179 GENE EXPRESSION PROFILES FOR THE INDUCED PHOSPHOLIPIDOSIS IN ZUCKER FATTY RAT VERSUS ZUCKER PRIMARY HEPATOCYTE AND PERIPHERAL DIABETIC FATTY RAT ARE HIGHLY BLOOD MONONUCLEAR CELL CULTURES CONSISTENT WITH THOSE OBSERVED IN USING A PHOSPHOLIPID-CONJUGATED HUMAN PATIENTS. D. Patel1, R. Rooney1 and S. FLUOROPROBE. R. Morgan1, R. Manoukian2, Groom2. 1Genome Explorations, Memphis, TN and S. Kaufman1, G. Elliot2, C. A. Afshari1 and H. 2Toxicology, Charles River Laboratories Preclinical K. Hamadeh1. 1Comparative Biology and Safety Montréal, Senneville, QC, Canada. Sponsor: M. Assessment, Amgen Inc., Thousand Oaks, CA and Vezina. 2Medical Sciences, Amgen Inc., Thousand Oaks, CA. #180 GENE EXPRESSION PROFILING OF RAT SKIN EXPOSED TO CUMENE #173 CASEIN-BASED DIETS ALTER SPRAGUE- HYDROPEROXIDE. A. Brys, L. Giannunzio, R. DAWLEY RAT PHENOTYPES. C. M. Rohde1, Jones, M. Hejtmancik, D. Gerken and L. Fomby. L. C. Robosky1, M. L. Manning2, D. F. Wells1, M. Battelle, Columbus, OH. D. Reily1 and D. G. Robertson1. 1Metabonomics Evaluation Group, Pfizer, Inc., Ann Arbor, MI and #181 PHENOBARBITAL-MEDIATED GENE 2Manpower, Ann Arbor, MI. EXPRESSION PROFILES IN MOUSE LIVER. L. Zheng1, A. Williams2, A. Yagminas1, C. Parfett1, #174 IMMUNOHISTOCHEMICAL AND G. Zhou1, G. Douglas1 and C. Yauk1. 1Health MALDI-TOF BASED TISSUE IMAGING Canada, Environment and Occupational Toxicology REVEAL CHANGES IN THE EXPRESSION, Division, HECSB, Ottawa, ON, Canada and 2Health LOCALIZATION, AND PHOSPHORYLATION Canada, Biostatistics and Epidemiology Division, OF ANNEXIN I AND II DURING CHEMICAL- HECSB, Ottawa, ON, Canada. Sponsor: R. Moody. INDUCED NEPHROCARCINOGENICITY. B. Leinweber1, N. Ma2, M. S. Chacko2, J. I. Everitt3, #182 BLOOD AS A TOXICOGENOMIC TISSUE. T. J. Monks1 and S. S. Lau1. 1Center for Toxicology, C. Pearson, S. Fujimoto, M. Judo, M. Sampson, L. University of Arizona, Tucson, AZ, 2Division of Brady, G. Napolitano, M. Fielden, K. Kolaja and Pharmacology/Toxicology, Uof Texas, Austin, TX D. Halbert. Iconix Pharmaceuticals, Inc., Mountain and 3GlaxoSmithKline, Research Triangle Park, NC. View, CA. #175 ELEVATIONS OF PRO-INFLAMMATORY #183 GLOBAL PROTEOMIC CHANGES IN MOUSE CYTOKINES AND DECREASES IN LUNG AFTER INHALATION EXPOSURE
CARDIOVASCULAR HEMODYNAMICS TO LIPOPOLYSACCHARIDE (LPS) AND/OR MONDAY 1 FOLLOWING INTRAVENOUS CIGARETTE SMOKE. D. L. Springer , R. E. 2 1 1 ADMINISTRATION OF RECOMBINANT Johnson , E. F. Strittmatter , R. J. Moore , J. G. 1 2 3 1 HUMAN ACID SPHINGOMYELINASE Pounds , K. M. Lee and J. H. Miller . Pacific (RHASM) TO ACID SPHINGOMYELINASE Northwest National Laboratory, Richland, WA, 2 KNOCK-OUT (ASMKO) MICE. J. M. Murray, Battelle Toxicology Northwest, Richland, WA and 3 A. D’Angona, C. Nickerson, A. Vitsky, M. Hawes, Washington State University-TriCities, Richland, S. Ryan, P. Ewing, B. Thurberg and L. Andrews. WA. Pharmacology/Toxicology, Genzyme Corporation, #184 EXPRESSION OF OSTEOPONTIN BY RAT Framingham, MA. ALVEOLAR MACROPHAGES IN VITRO. E. #176 MOLECULAR TARGETS AND TOXIC Bermudez and O. R. Moss. CIIT Centers for Health EFFECTS OF MICROCYSTIN-LR IN F344 Research, Research Triangle Park, NC. RATS. M. Billam, Q. Cai, S. Mukhi, L. Tang, R. J. #185 ANTIBODIES AGAINST FORMALDEHYDE- Kendall and J. Wang. Environmental Toxicology and ALBUMIN CONJUGATES IN RATS TREATED The Institute of Environmental and Human Health, WITH FORMALDEHYDE: POTENTIAL Texas Tech University, Lubbock, TX. BIOMARKER OF EXPOSURE. M. Khan, H. #177 EFFECT OF LOW LEVEL PROLONGED Li, J. Wang and G. Ansari. Pathology, University of EXPOSURES OF JP-8 ON THE BIOMARKER Texas Medical Branch, Galveston, TX. EXPRESSIONS IN THE SKIN OF WISTAR #186 IDENTIFICATION OF GLUTATHIONE 1 2 2 RATS. R. Babu , A. Chatterjee , S. Fulzele , N. DEPLETION-RESPONSIVE GENES IN 2 2 1 Verma and M. Singh . Auburn University, Auburn, RAT LIVER USING THE LARGE-SCALE 2 AL and College of Pharmacy, Florida A&M TOXICOGENOMIC DATABASE. N. Kiyosawa, University, Tallahassee, FL. A. Ono, T. Miyagishima, T. Urushidani and T. #178 DETECTION OF ANEUGENIC AND Nagao. Toxicogenoimcs Project, National Institute CLASTOGENIC AGENTS USING P53 AS A of Biomedical Innovation, Ibaraki, Osaka, Japan. MARKER OF GENOTOXICITY. H. Camacho, Sponsor: T. Inoue. S. K. Roy and D. A. Eastmond. Environmental #187 ANALYSIS OF HYDROXYBUTENYL- Toxicology Graduate Program, University of VALINE ADDUCTS IN RATS EXPOSED TO California, Riverside, Riverside, CA. BUTADIENE. N. I. Georgieva, G. Boysen, K. Jayaraj, A. Gold and J. A. Swenberg. ESE, University of North Carolina, Chapel Hill, NC. up-to-date information at www.toxicology.org 73
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B. D. D. and B. , H. Jordan 1 D. Hoivik , D. 1 and C. G. Woods C. G. 2 Drug Metabolism 2 , W. Casey W. , 1 . Center for Molecular Annual Meeting Annual th M. L. Takacs M. L. B. Faiola B. , B. Berridge, B. 1 , T. Borts T. , 2 B. Universtiy of. Bradford of. Universtiy , B. 1 SOT's 45 SOT's M. L. Cunningham IS REGULATED BY GSK3. α IS REGULATED , Nat’l Cntr. for Toxicogenomics Toxicogenomics for Cntr. Nat’l 1 2 , R. Peterson , C. Poole 1 1 , A. Maki , 1 J. D. D. J. δ) BY 4-HYDROXYNONENAL. Safety Assessment, GlaxoSmithKline, Safety / 1 β . 1 J. P. Vanden Heuvel Vanden P. and J.
University of North Carolina - Chapel Hill, Chapel University B. Romach B. ASSAY FOR EVALUATING THE BINDING OF FOR EVALUATING ASSAY THE TO (PFAAS) ACIDS PERFLUOROALKYL PROLIFERATOR-ACTIVATED PEROXISOME (PPARS). RECEPTORS (PPAR Y. Guo, R. Y. SPECIES SPECIFIC RESPONSES. A. G. Searfoss, H. Gao, Stutz, M. Huffman, J. Jolly, & Ryan. Eli Lilly T. and Stevens J. Baker, T. Irizarry, Thomas Sponsor: C. Greenfield, IN. company, . U.S. EPA, NHEERL, Research Triangle Triangle NHEERL, Research EPA, Abbott. U.S. NC. Park, AN OLD DOG: TRICKS FROM NEW OF PEROXISOME ACTIVATION RECEPTOR PROLIFERATOR-ACTIVATED Burns Miller VARIATION IN BIOLOGICAL RESPONSES VARIATION PROLIFERATORS PEROXISOME TO BETWEEN MOUSE STRAINS. M. Burns 1 Hill, NC and J. P. P. Thompson and J. T. Coleman, S. K. Prabhu, J. Sciences, and Biomedical Veterinary Heuvel. Vanden PA. State College, University, State Pennsylvania PROLIFERATOR-ACTIVATED PEROXISOME RECEPTOR M. Keener Toxicology and Carcinogenesis, The Pennsylvania The Pennsylvania and Carcinogenesis, Toxicology PA. Park, University State University, OF PPAR- CHARACTERIZATION AND IN DIABETIC INDUCED MYOPATHY NONDIABETIC RATS. W. Threadgill W. and Nat’l Toxicology Program, NIEHS, Research NIEHS, Program, Toxicology and Nat’l NC. Park, Triangle VITRO AN IN THE DEVELOPMENT OF Research Triangle Park, NC and Park, Triangle Research and Pharmacokinetics, GlaxoSmithKline, Research NC. Park, Triangle OF PPAR ANALYSIS A COMPARATIVE AND CANINE IN RODENT AGONISTS INTO AN INVESTIGATION HEPATOCYTES:
(Continued) Annual Annual th #196 9:30 AM to 12:00 NOON 9:30 Exhibit Hall PROLIFERATORS/PPAR PEROXISOME POSTER SESSION: Chapel Hill, of North Carolina Ivan Rusyn, University Chairperson(s): Agency, Protection Abbott, Environmental Chapel Hill, NC and Barbara NC. Park, Triangle Research NOON AM–12:00 9:30 Displayed: AM–12:00 NOON Attended: 10:30 #194 #197 #198 Monday, March 6 March Monday, #195 #199 45 74 , 2 Meeting & ToxExpo & Meeting
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4 , H. 2 1 5, 1 , C. 1 . , Y. Jiang Y. , 1 , Y. Jiang Y. , Genedata, Basel, 1 3 Department of X. Mo 2 W. Zheng and W. R. Gwiazda 4
, R. Lucchini 4 . H. Gmuender , S. Su 3 Genedata, Basel, Switzerland, Genedata, Basel, Switzerland, 1 Purdue University, West West Purdue University, School of Health Sciences, . 5 3 NIOSH, Cincinnati, OH, NIOSH, Cincinnati, OH, 1 3 , X. Li , R. Bowler 1 3 Department Occ Health & Hospital, Worker’s Guangxi Universite Catholique de Louvain, de Louvain, Catholique Universite 2 4 2 First Affiliated Hospital, Guangxi First 1 . 3 University of California, of Santa Cruz, University 1 , R. Park . , W. Zhao W. , 2 1 3 and A. Hohn and 1 Department Neurol, Guangxi Med. University Department Neurol, Guangxi Med. University Guangxi Med. University Department Radiology, Genedata, Basel, Switzerland and University of Brescia, Brescia, Italy. of University Santa Cruz, CA, H. Ahr Switzerland. Sponsor: H. Nanning, China, Nanning, China and 2 AS EXPOSURE ADDUCT HEMOGLOBIN MARKERS OF CHEMICAL SUBSTANCES. L. Long 1 Nanning, China, 3 W. Zheng and W. Nanning, China and BIOMARKERS OF MANGANESE EXPOSURE BIOMARKERS OF MANGANESE WELDERS. BRIDGE IN BAY A. Roels 5 (PB) IN SALIVA, DISPOSITION OF LEAD TISSUES AND BLOOD COMPONENTS, IN ORAL EXPOSURE REPEAT FOLLOWING and Wu H. A. Gies, R. Yantasee, W. THE RAT. , T. Isse, T. Murakami, T. Isse, T. Oyama , T. M. Ogawa, Kawamoto and T. Kinaga T. Yamaguchi, T. Pallez Francisco State University, San Francisco, CA and San Francisco, State University, Francisco . Pacific Northwest National Laboratory, . Pacific National Laboratory, Northwest Timchalk WA. Richland, A USEFUL AS ERYTHROCYTES ASSESSMENT FOR BIOLOGICAL MATRIX AMONG OF MANGANESE EXPOSURE Yang L. WORKERS. SMELTING Department of Environmental Health, University Health, University Department of Environmental Health, Japan, of Occupational and Environmental Japan. Kitakyushu, Toxicol, Guangxi Med. University Nanning, China, Guangxi Med. University Toxicol, Occup Health & Toxicol, Guangxi Med. University Med. University Guangxi Toxicol, Occup Health & Lafayette, IN. Lafayette, AND BIOMARKER TOXICOGENOMICS THE PREDICTION OF FOR DISCOVERY TOXICITY. TERM LONG Purdue University, West Lafayette, IN. Lafayette, West Purdue University, IMAGING RESONANCE BRAIN MAGNETIC TRACE AND BLOOD LEVELS OF AMONG MANGANESE- ELEMENTS WORKERS. EXPOSED STEEL Brussels, Belgium, D. Smith D. Nanning, China, Med. University 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#193 #189 #188
#190 Program Description Description Program #192 #191
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #200 DIFFERENTIAL GENE EXPRESSION #206 MICROARRAY ANALYSIS OF CLOFIBRIC IN LIVER ASSOCIATED WITH THE ACID-EXPOSED HUMAN AND RAT HEPATOPROTECTIVE EFFECT OF PRIMARY CULTURED HEPATOCYTES PEROXISOME PROLIFERATORS. J. S. Moffit1, AND CLOFIBRATE-TREATED RAT LIVER; P. H. Koza-Taylor2, R. D. Holland3, R. D. Beger3, EXTRAPOLATION OF CLOFIBRATE- M. P. Lawton2 and J. E. Manautou1. 1Department of INDUCED RNA EXPRESSION TO HUMAN? Pharmacology Sciences., University of Connecticut, S. Ogata1, Y. Suzuki1, T. Kitazima1, K. Ito1, N. Storrs, CT, 2Groton Laboratories, Molecular and Kiyosawa1, K. Watanabe1, N. Niino1, M. Kanbori1, T. Investigative Toxicology, Pfizer, Inc., Groton, CT Yamoto1, S. Manabe1, T. Fischer2, J. Mueller2 and M. and 3Division of Chemistry, National Center for Teranishi1. 1Medicinal Safety Research Laboratories, Toxicological Research, Jefferson, AR. Sankyo Co., Ltd., Fukuroi, Shizuoka, Japan and 2Drug Metabolism Department, Sankyo Pharma #201 MICE WITH PPARα KNOCKDOWN BY GmbH, Munich, Germany. siRNA ARE TRANSCRIPTIONALLY AND PHENOTYPICALLY COMPARABLE TO #207 PPARβ MODULATION OF GENE PPARα KNOCKOUT MICE. A. T. De Souza1, EXPRESSION IN A DIETARY MODEL OF X. Dai1, A. G. Spencer2, T. Reppen2, A. Menzie2, P. NONALCOHOLIC STEATOHEPATITIS. M. A. L. Roesch2, Y. He1, M. J. Caguyong1, S. Bloomer1, Peraza, M. J. Kennett and J. M. Peters. Department H. Herweijer2, J. A. Wolff2, J. E. Hagstrom2, D. L. of Veterinary and Biomedical Sciences, Center for Lewis2, P. S. Linsley1 and R. G. Ulrich1. 1Rosetta Molecular Toxicology and Carcinogenesis, The Inpharmatics, Merck & Co. Inc., Seattle, WA and Pennsylvania State University, University Park, PA. 2Mirus Bio Corporation, Madison, WI. #202 INDUCTION OF HEPATIC TRANSPORTERS Monday, March 6 MRP3 AND MRP4 BY CLOFIBRATE IS 9:30 AM to 12:00 NOON REGULATED BY PPARα J. E. Manautou1, J. Exhibit Hall S. Moffit1, L. M. Aleksunes1, J. M. Maher2, G. L. Scheffer3 and C. D. Klaassen2. 1Department of POSTER SESSION: AH RECEPTOR I Pharmacology Sciences., University of Connecticut, Storrs, CT, 2Department of Pharmacology, Chairperson(s): Sakina Eltom, Meharry Medical College, Nashville, TN Toxicology, and Therapeutics, University of Kansas and Rushang Patel, Penn State University, University Park, PA. 3 Medical Center, Kansas City, KS and Department Displayed: 9:30 AM–12:00 NOON of Pathology, VU Medical Center, Amsterdam, MONDAY Netherlands. Attended: 9:30 AM–11:00 AM #203 MECHANISTIC INVESTIGATIONS ON #208 β-NAPHTHOFLAVONE INDUCES MOUSE SPECIFIC TOXICITY WITH A TRANSCRIPTION OF CONSTITUTIVE PPARα/γ CO-AGONIST. F. Boess, L. Suter, E. ANDROSTANE RECEPTOR IN C57BL6/J A. Atzpodien, G. Hoffmann and M. Bopst. Non- MICE. R. D. Patel, B. D. Hollingshead and G. Clinical Development, F. Hoffmann - La Roche Ltd., H. Perdew. Center for Molecular Toxicology and Basel, Switzerland. Carcinogenesis, The Pennsylvania State University, University Park, PA. #204 IDENTIFICATION OF AUTOANTIBODIES TO ALDOLASE B IN SERA FROM PATIENTS #209 MECHANISMS OF INHIBITORY ARYL WITH TROGLITAZONE-INDUCED LIVER HYDROCARBON RECEPTOR-ESTROGEN DYSFUNCTION. T. Yokoi1, R. Maniratanachote1, RECEPTOR A/SP1 CROSSTALK IN BREAST A. Shibata1, S. Kaneko2, I. Yamamori3, T. Wakasugi4, CANCER CELLS. S. Liu1, S. Khan2, R. T. Sawazaki5, K. Katoh6, S. Tokudome7 and M. Barhoumi3, R. Burghardt3, K. Kim2 and S. Safe1, Nakajima1. 1Drug Metabolism and Toxicology, 2. 1Institute of Biosciences and Technology, Texas Faculty of Pharmaceutical Sciences, Kanazawa A&M University Health Science Center, Houston, University, Kanazawa, Japan, 2Graduate School of TX, 2Department of Veterinary Physiology & Medicine, Kanazawa University, Kanazawa, Japan, Pharmacology, Texas A&M University, College 3Nagoya First Red-Cross Hospital, Nagoya, Japan, Station, TX and 3Department of Veterinary 4Fukui Prefectural Hospital, Fukui, Japan, 5Hitachi Integrated Biology, Texas A&M University, College Chemical Co. Ltd., Hitachi, Japan, 6Institute of Station, TX. Developmental Research, Aichi Human Service Center, Aichi, Japan and 7Dokkyo University School #210 THE EFFECT OF CIGARETTE SMOKE of Medicine, Tochigi, Japan. Sponsor: T. Yoshida. CONSTITUENTS ON AHR SIGNALING AND SENESCENCE IN NORMAL HUMAN ORAL #205 DIFFERENTIAL GENE EXPRESSION IN KERATINOCYTES. L. Zhang1, J. Valentino2, R. PRIMARY HEPATOCYTES EXPOSED TO Dingle1, P. Xu1, D. Vongrises2 and H. I. Swanson1. THE PEROXISOME PROLIFERATORS 1Molecular and Biomedical Pharmacology, ACTIVATED RECEPTOR-α AGONISTS. L. University of Kentucky, Lexington, KY and Guo1, H. Fang1, S. Dial1, E. Blann1, J. Collins2 and Y. 2Surgery, University of Kentucky, Lexington, KY. Dragan1. 1Division of Systems Toxicology, National Center for Toxicological Research, Food and #211 RELEVANCE OF THE AHR GENE BATTERY Drug Administration, Jefferson, AR and 2Agilent FOR THE METABOLISM OF FRAGRANCES. Technologies, Inc., Palo Alto, CA. B. Bloemeke, M. Kalmes and S. Hahn-Quintes. Ecotoxicology, University Trier, Trier, Germany. up-to-date information at www.toxicology.org 75 . ,
1,
and 1 R. L. L. D. , L. D. Department 1 . 1, 2, 3 and J. C. Kwekel , J. National 2 1, 2, 3 Center for 1, 2, 3 N. Gharavi N. 3 E. A. Andreasen A. , E. Annual Meeting Annual T. R. Zacharewski and T. th Environmental and Environmental 1, 2, 3 1 . D. R. Boverhof , D. D. R. Boverhof D. 1, 2, 3 1, 2 , L. K. Mathew SOT's 45 SOT's 1, 2, 3 The Environmental Health Sciences The Environmental The Environmental Health Sciences The Environmental 2 2 Department of Environmental and Department of Environmental 1 T. R. Zacharewski and T. L. K. Mathew . E. Dere Fraunhofer Institut of Toxicology and Toxicology Institut of Fraunhofer 1 . 1 1, 2, 3 1, 2, 3 Fraunhofer Institute of Toxicology and Toxicology Institute of Fraunhofer 2 R. L. Tanguay and R. L. The Marine and Freshwater Biomedical Sciences The Marine and Freshwater The Marine and Freshwater Biomedical Sciences The Marine and Freshwater J. Borlak J. Experimental Medicine, Hannover, Germany Germany Experimental Medicine, Hannover, Tanguay Center, Oregon State University, Corvallis, OR. Corvallis, State University, Oregon Center, A HISTONE THE INFLUENCE OF THE GENE ON INHIBITOR DEACETYLASE INDUCED BY EXPRESSION PROFILES TCB. S. Reymann AND 1254 AROCLOR Center, Oregon State University, Corvallis, OR. Corvallis, State University, Oregon Center, GENE TCDD ON GLOBAL EFFECTS OF TISSUE. EXPRESSION IN REGENERATING L. D. Burgoon G. Humes, L. D. D. Department of Biochemistry & Molecular Biology, Department of Biochemistry & Molecular Biology, and Center, Toxicology Safety & National Food State Michigan Toxicology, Center for Integrative East Lansing, MI. University, E. A. Andreasen A. E. Burgoon 3 and Department, Furman Hestermann. Biology V. and E. SC. Greenville, University, IN OF NITRIC OXIDE THE ROLE ARYL OF THE DOWN-REGULATION RECEPTOR-REGULATED HYDROCARBON GENES BY INFLAMMATION. of Pharmacy and El-Kadi. Faculty and A. O. Alberta, of Pharmaceutical Sciences, University Canada. AB, Edmonton, AN ESTROGEN INDUCES DIOXIN DEPENDENT ESTROGEN-LIKE RECEPTOR THE GENE EXPRESSION RESPONSE IN MURINE UTERUS. IN VIVO AND IN VITRO OF IN COMPARISON East Lansing, MI. AND GENE EXPRESSION AHR SIGNALING CHANGES DURING REGENERATIVE GROWTH. 2, 3 3 GENE EXPRESSION RESPONSES MEDIATED MEDIATED RESPONSES EXPRESSION GENE TCDD. BY Integrative Toxicology, Michigan State University, State University, Michigan Toxicology, Integrative Experimental Medicine, Hannover, Germany. Experimental Medicine, Hannover, GENE REGULATION COMBINATORIAL ARYL AND THE ESTROGEN BY C. Bobowski RECEPTORS. HYDROCARBON Molecular Toxicology, Oregon State University, State University, Oregon Toxicology, Molecular OR, Corvallis, Food Safety & Toxicology Center, Michigan State Michigan Center, Toxicology Safety & Food MI and East Lansing, University, Molecular Toxicology, Oregon State University, State University, Oregon Toxicology, Molecular OR, Corvallis, OR and Corvallis, State University, Oregon Center, Center, Oregon State University, Corvallis, OR and Corvallis, State University, Oregon Center, of Biochemistry and Molecular Biology, Michigan Michigan of Biochemistry Biology, and Molecular MI, East Lansing, State University,
(Continued) Annual Annual th #224 #223 #226 #227 #221 #222 #225 45 76 .
Meeting & ToxExpo & Meeting Y. Y. , 1 . . , L. 1 . 1 1 ASTL, 1 . . 1 and A. Puga D. R. , D. 1 . Center T. A. and T. Department of 2 , N. M. Brown M. , N. 1, 2 S. Dahlin and R. S. Pollenz J. Reiners Jr. Reiners and J. Y. Xia and Y. 2 and E. Cooke 2 1 J. L. Marlowe J. E. C. Henry , W. H. Hanneman and W. , A. Puga , L. Peng and A. Puga X. Chang, L. Peng , A. Banerjee , , M. Sullivan
2 2 J. C. Bemis J. T. Zacharewski , T. R. Billings 2
X. Chang , Biochemistry and Molecular Biology, Michigan Michigan Biochemistry and Molecular Biology, 2 Institute of Environmental Health Sciences, Wayne Wayne Health Sciences, Institute of Environmental Safery Assessment, AstraZeneca, Loughborough, Assessment, Safery FL Tampa, Florida, of South University Biology, Z. Tan Z. Environmental Health, University of Cincinnati, Health, University Environmental 1 Detroit, MI. Cincinnati, OH. ANALYSIS CHIP-ON-CHIP MICROARRAY BINDING SITES IN AHR PROMOTER OF CELLS. HEPA-1C1C7 Cincinnati, OH. ENHANCEMENT OF DIOXIN-MEDIATED THE UBIQUITIN CYP1A1 INDUCTION BY A. Elliott A. 05RB. LIGASE INHIBITOR Detroit, MI and State University, CELLS. LIGANDS. State University, Wayne Pharmaceutical Sciences, . Pharmacology, Meharry Medical College, R. Dale. Pharmacology, TN. Nashville, OF SWITCH-LIKE ANALYSIS SINGLE CELL INDUCTION OF CYP1A1 BY HALOGENATED HEPATOMA IN RAT HYDROCARBONS Health, Colorado State University, Environmental Collins, CO. Fort RECEPTOR HYDROCARBON ARYL THE CELL CYCLE PROGRESSION REGULATES ABSENCE OF XENOBIOTIC THE IN United Kingdom. PROTEIN AH RECEPTOR OF ANALYSIS AND LUNG IN LIVER CONCENTRATION A SINGLE TO OF C57BL/6 MICE EXPOSED TCDD. ORAL DOSE OF 1 and AstraZeneca, Loughborough, United Kingdom and AstraZeneca, Loughborough, United Kingdom and 2 APPLICATION OF FUNCTIONAL TOXICITY TOXICITY OF FUNCTIONAL APPLICATION THE EFFECTS OF COMPARE TO ASSAYS ENDOGENOUS A POTENTIAL WITH TCDD RECEPTOR HYDROCARBON ARYL LIGAND. M. Graham Boverhof Padmavathi Environmental Health, University of Cincinnati, Health, University Environmental State University, East Lansing, MI. State University, (JNK)- KINASE THE C-JUN N-TERMINAL THYMUS. IN TOXICITY TCDD DEPENDENT for Environmental Genetics and Department of for Environmental of Cincinnati Health, University Environmental Cincinnati, OH. Medical Center, THE DIOXIN-INDUCED MEDIATES CALPAIN OF AND DOWN-REGULATION ACTIVATION RECEPTOR. HYDROCARBON ARYL THE . Environmental Medicine, University of Medicine, University . Environmental Gasiewicz NY. Rochester, Rochester, ASSAY AN IMAGING-BASED ARYL THE OF ACTIVATION FOR A RECEPTOR: HYDROCARBON HIGH MECHANISM-DEPENDENT, DRUG FOR ASSAY TOXICITY THROUGHPUT Garside H. J. DISCOVERY. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#212 Program Description Description Program #215 #216 #213
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #228 TCDD-INDUCED DIFFERENTIAL #234 DIFFERENTIAL GENE EXPRESSION IN COACTIVATOR RECRUITMENT TO CYP1A1 GCLM-NULL AND WILD-TYPE MICE AND CYP1B1. R. T. Taylor1, F. Wang2, R. Zhang2 EXPOSED TO DIESEL EXHAUST. E. C. Peck, and O. Hankinson2, 1. 1Molecular Toxicology IDP, L. A. McConnachie, R. P. Beyer, T. K. Bammler, University of California, Los Angeles, Los Angeles, C. Baker, D. Ceballos, P. A. Vliet, J. A. Stewart, CA and 2Department of Pathology and Laboratory D. L. Luchtel, J. D. Kaufman and T. J. Kavanagh. Medicine, Molecular Biology Institute, and Jonsson Environmental and Occupational Health Sciences, Comprehensive Cancer Center, David Geffen School University of Washington, Seattle, WA. of Medicine, University of California, Los Angeles, Los Angeles, CA. #235 VALIDATION OF THE PRO-INFLAMMATORY EFFECTS OF A DIESEL PM EXTRACT IN BEAS-2B CELLS AFTER AN EXPERIMENTAL Monday, March 6 SOLVENT EXCHANGE METHOD. K. J. 9:30 AM to 12:00 NOON Swanson1, M. C. Madden2, 1 and A. J. Ghio2. Exhibit Hall 1Environmental Sciences & Engineering, University of North Carolina - Chapel Hill, Chapel Hill, NC POSTER SESSION: RESPONSES TO PARTICULATES and 2HSD, NHEERL, U.S. EPA, Chapel Hill, NC. Chairperson(s): Steve Gavett, U.S. EPA, Research Triangle Park, NC and #236 ROLE OF TOLL LIKE RECEPTORS ON John Veranth, University of Utah, Salt Lake City, UT. PULMONARY INFLAMMATORY RESPONSES TO SIZE FRACTIONATED COMBUSTION Displayed: 9:30 AM–12:00 NOON AND AMBIENT AIR PARTICLES. I. Gilmour, M. Daniels, E. Boykin, W. Linak and R. Devlin. U.S. Attended: 10:30 AM–12:00 NOON EPA, Research Triangle Park, NC. #229 ACIDIC EXTRACTS OF WOOD SMOKE PARTICULATE MATTER CAUSE CASPASE #237 EFFECTS OF PM2.5 COLLECTED FROM INDEPENDENT APOPTOSIS IN MOUSE RAW CACHE VALLEY UTAH IN HUMAN AND MLE CELLS. K. A. Fay, C. D. Simpson, BRONCHIAL EPITHELIAL CELLS. T. L. 1 1 2 R. L. Dills, M. H. Paulsen and T. J. Kavanagh. Watterson , J. Sorenson , R. S. Martin and R. A. 1 1 Environmental and Occupational Health, University Coulombe . Graduate Toxicology Program and of WA, Seattle, WA. Department of Veterinary Sciences, Utah State University, Logan, UT and 2Department of Civil and #230 COMPARISON OF CIGARETTE SMOKE Environmental Engineering, Utah State University,
TOXICITY WITH VARIOUS INHALATION Logan, UT. MONDAY EXPOSURE REGIMENS. H. Yoshimura1, K. Yoshino1, G. Lulham2, K. M. Lee3 and R. A. Renne3. #238 INFLAMMATION AND TISSUE DAMAGE 1Japan Tobacco, Tokyo, Japan, 2JTI-Macdonald IN THE MOUSE LUNG CAUSED BY SIZE Corp., Toronto, ON, Canada and 3Battelle SEGREGATED PARTICULATE SAMPLES Toxicology Northwest, Richland, WA. COLLECTED IN DIFFERENT SEASONS IN HELSINKI. M. S. Happo1, 2, R. O. Salonen1, A. I. #231 CARBON MONOXIDE AND NITROGEN Halinen1, P. Jalava1, 2 and M. Hirvonen1. 1Department OXIDES ANALYSIS IN MAINSTREAM of Environmental Health, National Public Health SMOKE OF POTENTIALLY REDUCED Institute, Kuopio, Finland and 2University of EXPOSURE PRODUCTS(PREPS - QUEST1), Kuopio, Kuopio, Finland. Sponsor: M. Viluksela. MARLBORO MEDIUM, AND 2R4F CIGARETTES UNDER DIFFERENT PUFFING #239 CYTOTOXIC AND INFLAMMATORY REGIMENS. N. Gowadia1, M. Oldham1 and D. RESPONSES TO WATERSOLUBLE AND Dunn-Rankin2. 1Community and Environmental INSOLUBLE COMPONENTS OF SIZE- Medicine, University of California, Irvine, Irvine, SEGREGATED URBAN AIR PARTICULATE 1, 2 1 CA and 2Mechanical and Aerospace Engineering, MATTER IN VITRO. P. Jalava , R. O. Salonen , 1 1, 2 1 University of California, Irvine, Irvine, CA. A. I. Halinen , M. Happo , A. S. Pennanen , M. Sillanpaa3, R. Hillamo3 and M. Hirvonen1. #232 REAL TIME RT-PCR ASSESSMENT 1Department of Environmental Health, National OF CLEARANCE OF RESPIRATORY Public Health Institute (KTL), Kuopio, Finland, SYNCYTIAL VIRUS ALTERED BY 2University of Kuopio, Kuopio, Finland and 3Finnish EXPOSURE TO DIESEL EXHAUST AND Meteorological Institute, Helsinki, Finland. Sponsor: HARDWOOD SMOKE. M. D. Reed and J. A. M. Viluksela. Berger. Toxicology, Lovelace Respiratory Research Institute, Albuquerque, NM. #240 PULMONARY AND SYSTEMIC EFFECTS OF INHALED COAL FLY ASH PARTICLES #233 NEUROTROPHINS OPERATE AT DIFFERENT IN RATS. K. R. Smith1, J. M. Veranth2, Universtiy LEVELS OF THE RESPIRATORY TRACT of. P. Kodavanti3, M. C. Schladweiler3, I. Espiritu1, IN RESPONSES OF ALLERGIC MICE J. J. Recendez1, A. E. Aust4 and K. E. Pinkerton1. TO DIESEL EXHAUST PARTICLES 1Center for Health and the Environment, University (DEPARTMENT). S. H. Gavett, A. K. Farraj, N. of California, Davis, CA, 2Pharmacology and Haykal-Coates, A. D. Ledbetter and P. A. Evansky. Toxicology, University of Utah, Salt Lake City, UT, NHEERL U.S. EPA, Research Triangle Park, NC. 3NHEERL, U.S. EPA, Research Triangle Park, NC and 4Department of Chemistry and Biochemistry, Utah State University, Logan, UT. up-to-date information at www.toxicology.org 77 . , 1 , , 1 1 A. L. , . . 1 1 , , E. 1 2 . , 1 and , T. J. J. T. , Drug C. Nancy C. 3 2 College College , H. K. 2 1 , C. Jin 1 U.S. EPA, EPA, U.S. 1 , M. Daniels 2 . 1 , R. W. Diters W. , R. , H. Jeong Elan, South San C. Hurst 1 1 2 J. Clarke and J. Curriculum in 2 2 A. A. Levin and A. , S. Lee B. J. Meade J. , B. , D. G. Gonchoroff , D. 1 1 H. G. Haggerty H. G. , N. Catricks , N. Annual Meeting Annual 3 T. Stevens T. th Immunotoxicology, Immunotoxicology, 1 I. Gilmour . 2 , A. Basnet , KWS BioTest, Bristol, KWS BioTest, 1 , T. Bigwarfe T. , 1 Hunter Fleming Limited, Hunter Fleming Limited, 1 2 and . , R. Fey, , R. Fey, , K. Kramer-Stickland , N. Wehner , N. R. York , R. 1 2 1 2 S. P. Henry , S. P. College of Pharmacy, Yeungnam Yeungnam of Pharmacy, College 1 Currently Global Preclinical . 4 1 S. E. Anderson S. E. SOT's 45 SOT's Charles River Laboratories, Charles River , M. A. Abbott A. , M. 3 1 , D. Lee , D. 1 L. J. Shen L. J. , W. Linak W. , , H. Dong and E. Lochry , D. DeVona , D. 1 2 , V. Palmer V. , 1 1 1 , I. Jun 1 , J. Jones , J. and J. Murphy and J. 1 1, 4 T. Jeong and T. 1 Biogen Idec, Cambridge, MA and Idec, Cambridge, MA Biogen Francisco, CA. Francisco, THE ON ABATACEPT EFFECT OF R. Weiner R. B6C3F1 MICE. WV. E. Munson. NIOSH, Morgantown, Hill, Chapel Hill, NC. EFFECTS OF PROINFLAMMATORY (MOE) NON-CPG 2’METHOXYETHYL (ASO) IN ANTISENSE OLIGONUCLEOTIDES THE RAT. Hung G. E. Hatcher, IN CYNOMOLGUS MONKEYS. 1 DEVELOPING IMMUNE SYSTEM IN AND POSTNATAL OF PRE- A STUDY DEVELOPMENT IN RATS. Iciek L. Phelps and Horsham, PA G. Kim Lee Bone United Kingdom and Bristol, United Kingdom. Sponsor: R. Harling Orleans, France. Assessment, Servier, Drug Safety ON PRIMARY EFFECT OF NATALIZUMAB HUMORAL RESPONSES AND SECONDARY Bristol-Myers Squibb, East Syracuse, NY, Squibb, East Syracuse, NY, Bristol-Myers Davidson E. Boykin NC and Park, Triangle Research University, Gyeongsan, South Korea and South Korea Gyeongsan, University, CA. ISIS Pharmaceuticals, Inc., Carlsbad, IN THROBOCYTOPENIA DRUG-INDUCED G. Olivier, W. A CASE STUDY. DOGS: BEAGLE and Guy V. Helene, B. Anne, B. Francoise, of Pharmacy, Chosun University, Gwangju, South Gwangju, Chosun University, of Pharmacy, Korea. B- ENTEROTOXIN COLI HEAT-LABILE E. IMMUNE A POTENT (HF1020) IS SUBUNIT OF INHIBITING CAPABLE MODULATOR A MURINE IN INFLAMMATION AIRWAY Williams A. ASTHMA. N. MODEL OF Safety Evaluation, Bristol-Myers Squibb, New Squibb, New Bristol-Myers Safety Evaluation, Brunswick, NJ, TOXICOLOGIC INVESTIGATIONS OF 1- INVESTIGATIONS TOXICOLOGIC FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE SUBACUTE MICE: IN FEMALE BALB/C Jeon T. IMMUNOTOXICITY. EXPOSURE EFFECT OF DIESEL EXHAUST TO ON MUCOSAL SENSITIZATION ANTIGEN. OVALBUMIN S. Parker Safety, Abbott Laboratories, Abbott Park, IL. Abbott Park, Abbott Laboratories, Safety, WELDING FUMES THE EFFECT OF MMA-SS THE HUMORAL IMMUNE RESPONSE IN ON Toxicology, University of North Carolina - Chapel University Toxicology,
(Continued) Annual Annual th #253 #250 #252 #251 #248 #247 #249 #254 45 78 Meeting & ToxExpo & Meeting , 1 , J. , J. 1 S. , , M. 1 A. , E. Baja, IN
, M. Abbott , M. 1 J. McDonald J. Drug Safety , C. Comereski 1 2 . J. D. Frantz D. , J. J. M. Veranth M. J. 1 1 L. B. Mendez , L. B. T. P. Reilly P. T. , L. Case 1 , T. R. Webb and Webb R. T. , Warheit B. D. . Comm. & Env. M. Kleinman. Comm. & Env. , W. Freebern W. , 1 A. Campbell G. and G. Veranth , M. M. A. Reilly , C.
, J. Proctor , J. 2 H. G. Haggerty and H. G. 1 . Environmental Medicine, NYU L. Chen. Environmental . Toxicology, Lovelace Lovelace Toxicology, . L. Mauderly and J. , S. Wells , S. , H. Li and 1 The Jackson Laboratory, Bar Harbor, ME. Bar Harbor, The Jackson Laboratory, 2
Evaluation, Bristol-Myers Squibb, Syracuse, NY Bristol-Myers Evaluation, H. Fang School of Medicine, Tuxedo, NY. Tuxedo, School of Medicine, Seagrave Becaria K. Durham and ROLE OF IMMUNOMODULATION BY OF IMMUNOMODULATION ROLE THE SELECTIVE COSTIMULATION IN MOUSE ABATACEPT, MODULATOR, (MMTV)- VIRUS TUMOR MAMMARY TUMORS. INITIATED X. Jin and CHARACTERIZATION OF COARSE OF COARSE CHARACTERIZATION AND FINE (<PM2.5) (PM10-PM2.5) THE DUST IN RESUSPENDED ROADWAY SOUTHWEST SOUTHEAST, NORTHEAST, of.S. WESTERN Universtiy AND NM. Albuquerque, Respiratory Research Institute, INTERFERES MATTER PARTICULATE ASSAYS VITRO USED IN WITH COMMONLY OF AND CONFOUNDS INTERPRETATION RESULTS. EXPERIMENTAL ASSESS PULMONARY TO METHODS VITRO AND NANO- OF INHALED FINE TOXICITY SIZED PARTICLES. N. Cutler N. Koch, Medicine, University of CA, Irvine, Irvine,Medicine, University CA. ENHANCEMENT OF INNATE IMMUNE IMMUNE ENHANCEMENT OF INNATE EVENTS AND OXIDATIVE RESPONSES PARTICULATE TO AFTER EXPOSURE AIR PRESENT IN URBAN MATTER POLLUTION. . Pharmacology and Toxicology, University of University Toxicology, and . Pharmacology Yost S. UT. City, Utah, Salt Lake ALTERNATIVE DEVELOPMENT OF T. Golovkina T. K. L. Reed. DuPont Haskell Laboratory Haskell for Health K. L. Reed. DuPont DE. Sciences, Newark, and Environmental SAMPLING OF DAILY THE IMPORTANCE AMBIENT PARTICLES IN CONCENTRATED AND CELLULAR RESPONSE STUDY. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Monday, March 6 March Monday, : 9:30 AM–11:00 AM AM–11:00 Attended: 9:30 #245 Exhibit Hall IMMUNOMODULATION POSTER SESSION: Pullman, State Univerisity, Washington Lawrence, Paige Chairperson(s): NM. Albuquerque, Mexico, of New University and Scott Burchiel, WA AM–12:00 NOON 9:30 Displayed: 9:30 AM to 12:00 NOON 9:30 #242 #241 Program Description Description Program #246 #243 #244
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #255 EVALUATION OF PERFLUOROOCTANOIC #263 DUAL, INDEPENDENT MECHANISMS ACID IMMUNOTOXICITY IN ADULT MICE. OF ACTION OF ETHANOL IN THE B. Luebke1, C. B. Copeland1 and J. C. DeWitt2. MODULATION OF CYTOKINE 1Immunotoxicology Branch, U.S. EPA, ORD, PRODUCTION. M. Glover, Q. Zheng, R. Fan and NHEERL, ETD, Research Triangle Park, NC and S. B. Pruett. Cellular BIology & Anatomy, LSU 2Curriculum in Toxicology, University of North Health Sciences Center, Shreveport, LA. Carolina, Chapel Hill, NC. #264 THE ROLE OF P450 CYP1B1 AND EPHX1 IN #256 ORAL EXPOSURE TO PERFLUOROOCTANE 7, 12-DIMETHYLBENZ(A)-ANTHRACENE SULFONATE (PFOS) FOR 28 DAYS AND BENZO(A)PYRENE INDUCED SUPPRESSES IMMUNOLOGICAL IMMUNOTOXICITY IN C57BL/6N MICE. S. W. FUNCTION IN B6C3F1 MICE. M. Peden- Burchiel, J. Gao, L. Mitchell and F. T. Lauer. College Adams1, J. Stuckey2, J. EuDaly1 and D. Keil3. of Pharmacy Toxicology Program, The University of 1MUSC, Charleston, SC, 2College of Charleston, New Mexico, Albuquerque, NM. Charleston, SC and 3UNLV, Las Vegas, NV. #265 METALLOTHIONEIN GENE DOSE EFFECTS #257 AHR ACTIVATION PROTECTS MICE CADMIUM EFFECTS ON IMMUNE FROM LETHAL CHALLENGE WITH CAPACITY. M. Lynes, X. Yin, D. Unfricht, G. STREPTOCOCCUS PNEUMONIAE, BUT THE Jin and K. Zaffuto. Molecular and Cell Biology, IMPROVED SURVIVAL DOES NOT RESULT University of Connecticut, Storrs, CT. FROM AN ENHANCED INFLAMMATORY RESPONSE. B. A. Vorderstrasse and B. Lawrence. #266 CB1/CB2 DEPENDENT AND INDEPENDENT Pharmaceutical Sciences, Washington State IMMUNE MODULATION BY ∆9- University, Pullman, WA. TETRAHYDROCANNABINOL. A. E. Springs and N. E. Kaminski. Department of Pharmacology #258 DEFINING THE CONTRIBUTION OF ARYL and Toxicology and the Center for Integrative HYDROCARBON RECEPTOR (AHR)- Toxicology, Michigan State University, East MEDIATED DEFECTS IN DENDRITIC CELL Lansing, MI. AND T CELL FUNCTION RESULTING IN A DIMINISHED CYTOTOXIC T LYMPHOCYTE #267 DEVELOPMENT OF TOLERANCE TO (CTL) RESPONSE. J. J. Neumiller1, 2, J. A. Cundiff1 THE IMMUNOSUPPRESSIVE EFFECTS 9 and B. Lawrence1. 1Pharmaceutical Sciences, OF ∆ -TETRAHYDROCANNABINOL (THC) Washington State University, Pullman, WA and IN B6C3F1 MICE. C. M. Sheth and K. L.
2NIH Post-Doctoral Immunology Training Program, White. Pharmacology and Toxicology, Virginia MONDAY Pullman, WA. Commonwealth University, Richmond, VA. #259 REDUCED PARASITE BURDENS ARE NOT #268 ENHANCED CYTOTOXIC T CELL ACTIVITY CORRELATED WITH ELEVATED TNF FOLLOWING EXPOSURE TO COMMERCIAL 1 LEVELS IN LEISHMANIA MAJOR-INFECTED ECHINACEA PURPUREA. K. L. White , D. 2 1 1 TCDD-TREATED MICE. K. Sommersted and G. R. Germolec , W. Auttachoat , R. Brown , D. L. 1 1 1 DeKrey. School of Biological Sciences, University Musgrove and T. L. Guo . Pharmacology and of Northern Colorado, Greeley, CO. Toxicology, Virginia Commonwealth Univeristy, Richmond, VA and 2NIEHS, Research Triangle Park, #260 INVESTIGATING THE ROLE OF THE NC. NEUROIMMUNE AXIS IN PCB-INDUCED IMMUNOTOXICITY USING A FISH #269 SUNSCREENS PREVENT ULTRAVIOLET MODEL. J. Duffy and J. T. Zelikoff. Department RADIATION-INDUCED IMMUNE of Environmental Medicine, New York University SUPPRESSION OF CONTACT School of Medicine, Tuxedo, NY. HYPERSENSITIVITY IN HAIRLESS MICE. H. Kim, J. Lee, J. Sin, J. Gil, J. Kim, J. Kim, Y. Jo #261 T-2 TOXIN DIMINISHES HOST RESISTANCE and K. Park. Immunotoxicology, National Institute TO RESPIRATORY REOVIRUS INFECTION. of Toxicological Research, Seoul, South Korea. M. Li1, 2, 3, J. R. Harkema3, Z. Islam1, 2, 3, C. F. Cuff4 Sponsor: Y. Heo. and J. Pestka1, 2, 3. 1Department of Microbiology and Molecular Denetics, Michigan State University, #270 PERSISTENT SUPPRESSION OF THE East Laning, MI, 2Food Science and Human PRIMARY HUMORAL IMMUNE RESPONSE Nutrition, Michigan State University, East Laning, TO SHEEP RED BLOOD CELLS IN MI, 3Pathobiology and Diagnostic Investigation, RATS POST-NATALLY EXPOSED TO 1 2 Michigan State University, East Laning, MI and CYCLOSPORINE. G. Ravel , J. Descotes , F. 1 1 1 4Department of Microbilogy and Immunology, West Horand and P. C. Barrow . MDS Pharma Services, 2 Virginia University, Morgantown, WV. St Germain s/L’Arbresle, France and Poison Center, Lyon, France. #262 AN ANIMAL MODEL FOR DETRIMENTAL AND BENEFICIAL EFFECTS OF ETHANOL WITH REGARD TO THE ACUTE PHASE RESPONSE. B. S. Pruett and S. B. Pruett. Cellular BIology & Anatomy, LSU Health Sciences Center, Shreveport, LA. up-to-date information at www.toxicology.org 79 , , T. T. 2 , 2 2 , , 2 M. 1 E. . 2 , M. 1 and and 1 R. M.
Secretaria de 3 S. D. and S. D. 3 , M. Maroni 4 , M. Guerrero , S. Birindelli 1 1 , S. Birindelli ICPS, Hospital G. Garcia- and G. 1 2 , S. J. Duarte , S. J. 3 1 Annual Meeting Annual D. G. Farrer G. D. and C. Colosio EXPOSURE IS 1 th S. Maugeri Foundation, S. Maugeri Foundation, 3 , L. Campo , D. E. Jones , D. 4 E. Corsini 2 Medical Research Council, , M. Marinovich ICPS, Hospital L. Sacco, C. L. Galli 2 2 2
, M. Hernandez-Serrano College of Veterinary Veterinary of College 1 3 , M. Rosales-Gonzalez 1 C. L. Galli SOT's 45 SOT's , G. Garcia-Arenas , , V. Lujan-Galvan V. , 1 5 3 Mario Negri Institute, Milan, Italy, Mario Negri Milan, Italy, Institute, 3 Biomedical Sciences, EVVCOM, Va Va Biomedical Sciences, EVVCOM, 1 , C. Colosio , S. Fustinoni STUDIES. Department Sciences, Pharmacological 3 . 3 Centro de Investigaciones Biomedicas, Centro de Investigaciones Facultad de Medicina, Universidad Juarez de Medicina, Universidad Facultad 1 , J. Candelas , J. 3 2 1 1 , O. N. Ofordile N. , O. . . 1 1 1, 3 via, Italy. Department Pharmacological Sciences, University Department Sciences, University Pharmacological Department of occupational and Environmental Netherlands. RIVM, Bilthoven, Pa University of Milan, Milan, Italy, of Milan, Milan, Italy, University H. Van Loveren Van H. . Environmental Medicine, University of Medicine, University . Environmental McCabe J. NY. Rochester, Rochester, ACID SUCCINIC DIMERCAPTO T INCREASE TREATMENT (DMSA) RESPONSE IN CD4 LYMPHOCYTES CASES LEAD POISONED CHILDREN. R. C. Goytia PRESENTATION. of Milan, Milan, Italy, and of Milan, Milan, Italy Health, University EFFECTS OF IMMUNOMODULATORY ON HUMAN THE HERBICIDE PROPANIL AND VIVO IN PRODUCTION: CYTOKINE VITRO IN L. Sacco, Milan, Italy and L. Sacco, Milan, Italy Holladay Almeida and Coahuila, Mexico Torreon, UAC, C. Bosetti 1 4 5 C. Minoia , W. Auttachoat, D. M. Hernandez and R. P. M. Hernandez and R. P. D. Auttachoat, W. L. Guo, Richmond, University, Commonwealth Virginia Chi. VA. OXIDE LEAD INHIBITS NITRIC IN MYELOID SUPPRESSOR PRODUCTION T IN UNREGULATED CELLS RESULTING CELL PROLIFERATION. Rubio-Andrade Salud, Torreon, Coahuila, Mexico. Torreon, Salud, THE EFFECTS OF OF EVALUATION THE IMMUNE MANCOZEB EXPOSURE ON WORKERS: AGRICULTURE SYSTEM OF STUDY. AN ITALIAN LINK BETWEEN PERINATAL A POTENTIAL ADULT AND PESTICIDE EXPOSURE AFRICA. IN RURAL MORTALITY GENISTEIN MODULATION OF IGE GENISTEIN MODULATION MICE B6C3F1 ADULT BY PRODUCTION IN UTERO FOLLOWING Medicine, VA Tech, Blacksburg, VA. Blacksburg, Tech, VA Medicine, Milan, Italy, Milan, Italy, AFFECTED BY SEX AND LITTER ORDER. AND LITTER AFFECTED BY SEX A. Torres-Vega A. Keneba, Gambia and Keneba, Gogal Vargas Durango, del Estado de Durango, Gómez Palacio, Mexico, VA, Blacksburg, Tech, R. Meza-Velazquez Corsini
(Continued) Annual Annual th #280 #282 #279 #281 #283 #278 45 80 Meeting & ToxExpo & Meeting . and 3 . 2 2, 1 , F. , F. and M. 1 , K. 2 , J. Cunnick , J. Department 2 2 Health and Human and Health S. P. Ng , S. P. INDUCTION 2 and T. Takita T. and 3 , G. Ravel Department of 1 MDS Pharma 3 1 VIA . 2 , C. Yashiro , C. 1 P. B. Lawrence B. and P. 2 , M. Kohut 1 J. T. Zelikoff T. J. M. Tsunoda , M. Department of Pharmaceutical 2 2 Food Science and Human Nutrition, Science and Human Nutrition, Food 1 . J. Descotes and J. 1 , J. A. Cundiff , J. 1 1 . Pharmacology and White. Pharmacology and K. L. Y. Sugita-Konishi Y. C. A. Landgren C. School of Molecular Biosciences, Biotechnology School of Molecular Biosciences, Biotechnology Division of Microbiology, National Institute of Microbiology, Division Animal Science, Iowa State University, Ames, IA. State University, Animal Science, Iowa Poison Center, Lyon, France. Lyon, Center, Poison Kobayashi-Hattori Condevaux IA, Ames, University, State Iowa S. Hendrich Toxicology, Virginia Commonwealth University, University, Commonwealth Virginia Toxicology, VA. Richmond, 1 State University, Washington Program, Training and WA Pullman, THE OFFSPRING. 1 Japan, Tokyo, of Health Sciences, OF APOPTOSIS AND CYTOKINES IN B6C3F1 AND CYTOKINES APOPTOSIS OF Auttachoat, W. M. Hernandez, B6C3F1 MICE. D. L. Guo T. IMMUNOSUPPRESSIVE EFFECT ON MICE FOLLOWING F1 GENERATION TO EXPOSURE GESTATIONAL T-2 MYCOTOXIN, TRICHOTHECENES TOXIN. DEOXYNIVALENOL INDUCES DEOXYNIVALENOL IMMUNOSUPPRESSION H. Kang and , H. Ku, Cho, S. Jeong MICE. J. Anyang, NVRQS, Division, Toxicology H. Pyo. South Korea. Kyunggi, THE IMMUNE OF ALTERATIONS OF SYSTEM DURING CRITICAL STAGES EXPOSURE DEVELOPMENT FOLLOWING IN (DBA) 6 DIBENZANTHRACENE 2:5, 1, TO MICE. 3 HUMORAL RESPONSE TO KLH AND KLH TO HUMORAL RESPONSE ANALYSIS SUBSET LYMPHOCYTE WITH TREATED IN MONKEYS Horand CYCLOSPORINE. F. 2 EFFECTS OF IMMUNOMODULATORY DEOXYNIVALENOL DIETARY LOW-DOSE IN BALB/C EXERCISE STRESS ACUTE AND Sciences, Washington State University, Pullman, State University, Washington Sciences, WA. Performance, Iowa State University, Ames, IA and State University, Iowa Performance, Services, St Germain s/L’Arbresle, France and France Services, St Germain s/L’Arbresle, of Nutritional Sciences, Tokyo University of University Tokyo of Nutritional Sciences, Japan and Tokyo, Agriculture, Medicine, Kitasato University, Kanagawa, Japan. Kanagawa, Medicine, Kitasato University, CIGARETTE TO EXPOSURE PRENATAL ATROPHY THYMIC SMOKE PRODUCES T-LYMPHOCYTE-MEDIATED ALTERS AND MECHANISMS IN TUMOR SURVEILLANCE C. Bosland. Environmental Medicine, New York York Medicine, New C. Bosland. Environmental NY. Tuxedo, School of Medicine, University THE DEVELOPMENTAL IDENTIFYING ACTIVATION AHR WHICH IN WINDOW IN IMMUNE ALTERATIONS TO LEADS P. ON IN LIFE. J. FUNCTION LATER Hogaboam 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#276 Program Description Description Program #277
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #284 MERCURY EXPOSURE INCREASES #290 PATHOBIOLOGY OF A VALVULOPATHY BIOMARKERS OF AUTOIMMUNE IN FISCHER 344 RATS GIVEN A DYSFUNCTION IN AN EXPOSED GOLD TRANSFORMING GROWTH FACTOR-β MINING POPULATION COMPARED TO RI KINASE INHIBITOR. A. J. Stauber, J. L. OCCUPATIONAL REFERENCE GROUPS. Zimmermann and B. Berridge. Toxicology Division, R. M. Gardner, J. Nyland and E. K. Silbergeld. Eli Lilly and Company, Greenfield, IN. Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. #291 QUANTITATIVE MORPHOLOGIC ASSESSMENT ON EXTRACELLULAR #285 PROTECTION OF NON-OBESE DIABETIC MATRIX IN CHEMICAL-INDUCED (NOD) MICE FROM AUTOIMMUNE DEVELOPMENTAL DISSECTING AORTIC DIABETES BY ESCHERICHIA COLI ANEURYSM USING MULTIPHOTON HEAT-LABILE ENTEROTOXIN B SUBUNIT FLORESCENCE AND SECOND HARMONIC (HF1020). J. Murphy1, N. A. Williams2 and T. Ola2. GENERATION MICROSCOPY. B. gong1, 1Hunter-Fleming Limited, Bristol, United Kingdom L. Wang1, 3, J. Sun2, G. Vargas2 and P. Boor1. and 2KWS BioTest, Bristol, United Kingdom. 1Cardiovascular Toxicology, Pathology, UTMB, Sponsor: R. Harling. Galveston, TX, 2Center of Biomedical Engineering, UTMB, Galveston, TX and 3Division of #286 ESCHERICHIA COLI HEAT-LABILE Cardiovascular Medicine, Medical School of ENTEROTOXIN B-SUBUNIT (HF1020) University of Nanjing, Nanjing, Jiangsu, China. PREVENTS AUTOIMMUNE ARTHRITIS THROUGH THE INDUCTION OF #292 SCREENING OF RELATIVE TOXICITY AND REGULATORY CD4+ T CELLS. J. Luross1, N. A. ACTIVITY OF SEVERAL CRP ANTISENSE Williams1 and J. Murphy2. 1KWS BioTest, Bristol, INHIBITORS IN CYNOMOLGUS MONKEYS. United Kingdom and 2Hunter-Fleming Limited, S. Henry1, T. A. Zanardi1, M. J. Graham1, M. Bristol, United Kingdom. Sponsor: R. Harling. Mazzone2, R. Early2, R. M. Crooke1 and A. A. Levin1. 1ISIS Pharmaceuticals, Inc., Carlsbad, CA and #287 IMMUNO- AND HEPATOTOXICITY OF 2Charles River Laboratories, Sparks, NV. DICHOLOROACETIC ACID IN MRL +/+ AND B6C3F1 MICE. P. Cai, B. S. Kaphalia and G. #293 THE PREVENTION OF RESTENOSIS BY Ansari. Pathology, UTMB, Galveston, TX. SIROLIMUS:A PHARMACOGENOMICS APPROACH. E. Koo1, R. Thyagarajan3, D. #288 LIFETIME EXPOSURE TO Argentieri3, J. Siekerka3, R. Falotico3, D. Jack1,
TRICHLOROETHYLENE (TCE) DOES NOT Q. Liu1, C. Alveres1, S. Weyer1, P. Miller1, S. MONDAY ACCELERATE AUTOIMMUNE DISEASE IN Godin1 and T. Parry2. 1Toxicology, Gene Logic 1 2 2 MRL +/+ MICE. D. Keil , J. EuDaly , J. Miller , G. Inc., Gaithersburg, MD, 2Johnson & Johnson 2 2 1 Gilkeson and M. Peden-Adams . UNLV, Las Vegas, Pharmaceutical, Spring House, PA and 3Cordis 2 NV and MUSC, Charleston, SC. Corporation, Warren, NJ. #294 USING GENE EXPRESSION PROFILING Monday, March 6 AND MOLECULAR PATHWAY ANALYSIS TO 9:30 AM to 12:00 NOON EXAMINE THE PATHOGENESIS OF DRUG Exhibit Hall INDUCED VASCULAR INJURY IN CANINE CORONARY ARTERIES. B. E. Enerson1, A. Lin1, POSTER SESSION: CARDIOVASCULAR SYSTEM: VALVULAR B. Lu2, L. F. Nelms2, P. Koza-Taylor2, H. Zhao1, AND VASCULAR INJURY M. P. Lawton2, J. R. Bender1 and E. Floyd2. 1Yale 2 Chairperson(s): Cheste Ni, Pfizer Global Research & Development, Ann University, New Haven, CT and Safety Sciences, Arbor, MI and Kazim Husain, Ponce School of Medicine, Ponce, Puerto Pfizer, Groton, CT. Rico. #295 A PROINFLAMMATORY ROLE OF MAST Displayed: 9:30 AM–12:00 NOON CELL DEGRANULATION (MCD) IN DRUG-INDUCED VASCULAR INJURY IN Attended: 10:30 AM–12:00 NOON SPRAGUE-DAWLEY RATS. J. Zhang1, A. Knapton1, T. J. Miller1, P. Espandiari1, R. Anderson1, #289 EXPLORATION OF VALVULAR HEART E. H. Herman1, R. Snyder2, J. Hanig1 and J. L. DISEASE IN NEONATAL RATS CO- Weaver1. 1CDER, USFDA, Silver Spring, MD and ADMINISTERED FENFLURAMINE AND 2Schering-Plough Research Institute, Lafayette, NJ. PHENTERMINE. T. K. Baker1, L. M. Munsie1, A. V. Wilke3, J. L. Stevens1, J. L. Hanes4, K. B. Donnelly2 #296 IN-SITU PERFUSION OF RAT MESENTERY and M. A. Davis1. 1Investigative Toxicology, Eli Lilly WITH DRUGS TO EVALUATE ROLE OF and Company, Greenfield, IN, 2Endocrine/Cancer MAST CELL DEGRANUALTION IN EARLY Pathology, Eli Lilly, Greenfield, IN, 3Cardiovascular MESENTERIC VASCULAR INFLAMMATION. Safety Assessment, Eli Lilly, Greenfield, IN and A. D. Knapton1, J. Zhang1, J. L. Weaver1, F. D. 4Animal Studies, Eli Lilly and Company, Greenfield, Sistare2 and J. Hanig1. 1CDER, USFDA, Silver IN. Spring, MD and 2Merck, West Point, PA.
up-to-date information at www.toxicology.org 81 . , , S. 2 1 . 1 , 1 , S. 2 ISIS 1 Charles . 2 B. B. 1 T. Kim T. P. B. Lappin B. , P. 1 M. J. Graham , M. J. 1 Annual Meeting Annual , A. S. Adeagbo A. S. , th D. J. Conklin J. and D. 2 1 , M. V. Ortiz V. K. Husain, M.
S. P. Henry and S. P. . 1 , R. M. Crooke 1 SOT's 45 SOT's and www.toxicology.org in the Exhibit , A. Bhatnagar , A. A. Levin , A. 2 2 H. Haussmann Physiology and Biophysics, University of University and Biophysics, Physiology , K. Kramer-Stickland 2 2
Cardiology, University of Louisville, Louisville, University Cardiology, Louisville, Louisville, KY. ALCOHOL-INDUCED CHRONIC REACTIVITY AORTIC AND HYPERTENSION RESPONSES IN RATS. TREATMENT WITH TREATMENT VIVO IN INDUCES ANTIRETROVIRALS AND DYSFUNCITON ENDOTHELIAL ATHEROGENESIS. EXACERBATES and J. L. Ortiz. Pharmacology and Toxicology, Ponce Ponce Toxicology, Ortiz. L. and Pharmacology and J. Puerto Rico. School of Medicine, Ponce, ANTISENSE AN ISIS 326358 APOB TO TARGETED OLIGONUCLEOTIDE A MONKEY REDUCES PLASMA LDL-C IN S. Lebrun, W. Stinn, H. Weiler, P. Kuhl, K. Kuhl, P. Weiler, Stinn, H. W. DIETS. S. Lebrun, and R. Schleef. Philip Morris Wallerath T. Holt, von Germany. Research Laboratories GmbH, Cologne, Sponsor: R. Dugas and T. H. Zavecz Hebert, J. Y. V. Jiang, ACROLEIN-INDUCED ENDOTHELIUM- ACROLEIN-INDUCED IN RODENT VASODILATATION DEPENDENT AN NO-INDEPENDENT MESENTERIC BED: Awe MECHANISM. S. O. E. D’Souza 1 KY and MODEL OF HYPERLIPIDEMIA. H. Rose LSU Health Sciences Center, Pharmacology, LA. Shreveport, G. S. Elliot G. K. Subramaniam Pharmaceuticals, Inc., Carlsbad, CA and CA Pharmaceuticals, Inc., Carlsbad, River Laboratories, Sparks, NV. River CIGARETTE MAINSTREAM CHRONIC SMOKE EXPOSURE INCREASES PLAQUE ARTERY THE BRACHIOCEPHALIC SIZE IN E-DEFICIENT MICE APOLIPOPROTEIN IN AND MILK-FAT-ENRICHED ON CHOW
Anniversary Celebration, SOT will be giving away a total th Monday Afternoon Anniversary Raffle Contest will be held in the Exhibit Hall th (Continued) ANNIVERSARY RAFFLE CONTEST ANNIVERSARY Annual Annual TH th #307 SOT 45 of $4500 over of a $4500 period! three-day over More details and contest rules are on the SOT Annual Meeting Web site at #310 #308 Hall on-site. Monday, March 6 March Monday, 12:00 NOON to 1:30 PM Exhibit Hall 45 #306 Monday, Tuesday, and Wednesday between 12:00 NOON and Wednesday and 1:30 As PM. Tuesday, Monday, part of the 45 #309 45 82
Meeting & ToxExpo & Meeting . IN 3 . , , E. 1 1 P. S. , P. 1 Safety 3 . B. K. Philip , B. M. J. , M. J. 1 Cardiology, Cardiology, F. Clemo and F. 1 2 . 1 D. J. Conklin J. , D. 2 H. Haussmann H. M. Mehendale and A. E. and Felty Q.
G. M. Williams M. and G. P. S. Palkar P. 2 S. Duddy , 2 . -ADRENERGIC AGONIST- α-ADRENERGIC S. E. D’Souza and S. Srivastava 1 G. L. Fisher , G. 1 J. Paulauskis , J. T. Wallerath, K. von Holt and R. Schleef. K. von Holt and R. Schleef. Wallerath, T. . 1 . Department of Toxicology, Toxicology, K. Philip. Department of and B. ACTIVATION DISRUPTS PCB- DISRUPTS ACTIVATION α Research, Wyeth, Collegeville, PA. Collegeville, Wyeth, Research, 2 . Department of Toxicology, Toxicology, H. M. Mehendale. Department of Pathology, New York Medical College, Valhalla, NY Valhalla, Medical College, York New Pathology, Chemical Technologies, Pfizer, Ann Arbor, MI, Arbor, Ann Pfizer, Technologies, Chemical MI and Arbor, Ann Safety Sciences, Pfizer, Physiology & Biophysics, University of Louisville, University & Biophysics, Physiology Gifford INDUCED PROINFLAMMATORY INDUCED PROINFLAMMATORY VASCULAR IN PATHWAYS SIGNALING G. Reiterer, Arzuaga, CELLS. X. ENDOTHELIAL and B. Toborek Kilgore, M. W. M. Z. Majkova, University of Louisiana at Monroe, Monroe, LA. of Louisiana at Monroe, Monroe, University OF EXTRACTS AQUEOUS EFFECTS OF University of Louisville, Louisville, KY and of University Sciences, Pfizer, Groton, CT. Leisy. Florida International University, Miami, FL. International Florida University, Leisy. PPAR EFFECT OF AMINOREX IN A HYPOXIA- AMINOREX IN EFFECT OF HYPERTENSION INDUCED PULMONARY VITRO . University of Kentucky, Lexington, KY, KY. KY, Lexington, Kentucky, of University Hennig. and CAUSED CONSTRICTION OF RAT AORTA AORTA CONSTRICTION OF RAT CAUSED of Zhao. College and B. Wang T. Wang, RINGS. D. of South Carolina, Columbia, University Pharmacy, Su SC. Sponsor: W. MODEL IN MICE. C. E. Perrone 1 ACID-LEACHABLE COMPONENTS OF COMPONENTS ACID-LEACHABLE DISRUPT MATTER PARTICULATE AMBIENT INTEGRITY MONOLAYER ENDOTHELIAL AND ENHANCE and CIGARETTE MAINSTREAM SMOKE THE NOREPINEPHRINE-INDUCED ON RINGS AORTIC OF RAT CONTRACTION PRIMING DOSE OF PHENYLHYDRAZINE PRIMING DOSE OF PHENYLHYDRAZINE LETHAL EFFECTS AGAINST PROTECTS OF BUTOXYETHANOL. 1 2 ACROLEIN MEDIATES PLATELET PLATELET MEDIATES ACROLEIN ACTIVATION. 2 Louisville, KY. STRUCTURE-TOXICITY-RELATIONSHIP MODELING FOR DRUG-ASSOCIATED POSITIVE IN HUMANS: VASCULITIS A BENZENE- WITH ASSOCIATION A POSSIBLE AND MOTIF SULFONAMIDE Ni T. C. MYELOPEROXIDASE. TO LINK Palkar Philip Morris Research Laboratories GmbH, Laboratories Philip Morris Research Sponsor: Germany. Cologne, MECHANISM OF ADVERSE EFFECTS OF EFFECTS ADVERSE MECHANISM OF REPLACEMENT UNOPPOSED ESTROGEN OF THE GROWTH THERAPY ON CELLS. ENDOTHELIAL Iatropoulos University of Louisiana, Monroe, LA. University PROTEINS OF DEATH INVOLVEMENT THEIR ENDOGENOUS INHIBITORS AND AND REGRESSION OF IN PROGRESSION INJURY. HEMOLYTIC A. Bhatnagar 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#301 #299 #305 #303 #302 #298 #297 Program Description Description Program #304 #300
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Monday, March 6 #312 1:35 TEMPORAL CORRELATION OF 12:00 NOON to 1:30 PM PATHOLOGY AND MARKERS OF Room 4 OXIDATIVE STRESS WITH GENE EXPRESSION IN RAT LIVER SPECIALTY SECTION MEETING/RECEPTION: COMPARATIVE CARCINOGENESIS. I. Rusyn and C. Powell. AND VETERINARY University of North Carolina at Chapel Hill, Chapel Hill, NC. Monday, March 6 #313 2:10 EXPLOITING PHENOTYPIC ANCHORING 12:00 NOON to 1:30 PM TO REVEAL GENE EXPRESSION Room 3 INDICATORS OF INCIPIENT TOXICITY. R. S. Paules and N. Members of the NCT ToxPath SPECIALTY SECTION MEETING/RECEPTION: OCCUPATIONAL Team. National Center for Toxicogenomics, AND PUBLIC HEALTH National Institute of Environmental Health Sciences, Research Triangle Park, NC. Monday, March 6 1:30 PM to 4:30 PM #314 2:45 GASTROINTESTINAL TOXICITY AS A Room 6F CONTRIBUTOR TO HEPATOTOXICITY ASSOCIATED WITH A P38 ALPHA KINASE SYMPOSIUM SESSION: ADVANCING TOXICOLOGY BY INHIBITOR. H. Hamadeh. Toxicology, Amgen IMPROVING LINKAGE OF TRADITIONAL TOXICITY AND Inc., Thousand Oaks, CA. PATHOLOGY ENDPOINTS WITH TOXICOGENOMICS #315 3:20 COMPARATIVE ANALYSIS OF THE Chairperson(s): Ivan Rusyn, University of North Carolina Chapel Hill, RODENT UTEROTROPIC RESPONSE: Chapel Hill, NC and Richard Paules, NIEHS, Research Triangle Park, NC. IDENTIFICATION OF CONSERVED RESPONSES AND MECHANISMS OF Endorsed by: ACTION. T. Zacharewski. Biochemistry, Michigan Carcinogenesis SS State University, East Lansing, MI. Mechanisms SS #316 3:55 GENETIC VARIATION AS A NEW Toxicologic and Exploratory Pathology SS* DIMENSION IN TOXICOLOGY. D. Threadgill1, 2, 4 3, 2, 4 4 4 Toxicogenomics has recently emerged as an extremely promising sub- , I. Rusyn , A. Hege , A. Bissahoyo and M. La 4 1 discipline of environmental health sciences. It has received an enormous Merrrill . Genetics, University of North Carolina, 2 amount of attention at a large number of international toxicology meetings Chapel Hill, NC, Center for Environmental Health MONDAY as a powerful, new tool for toxicologists that may considerably accelerate and Susceptibility, University of North Carolina, 3 discovery of the mechanisms of environment-associated diseases, reveal Chapel Hill, NC, Environmental Sciences and novel biomarkers or surrogate biomarkers of both exposure and effect, Engineering, University of North Carolina, Chapel 4 improve scientists’ ability to characterize hazard, and serve as a foundation Hill, NC and Curriculum in Toxicology, University for advancing risk assessment. Careful assessment of linkages between of North Carolina, Chapel Hill, NC. the omics data and conventional parameters of toxicity is very important for both validation and evaluation of toxicogenomics data. Phenotypic anchoring of gene expression data to toxicological and pathological indices removes the subjectivity of novel molecular analyses and is important to distinguish the toxicological effect from changes that may be unrelated to toxicity. Importantly, several recent studies demonstrated the utility of this approach and showed how a careful examination of different types of the data available to the toxicologists today helps to understand organ-specific toxic events, identify conserved responses across species, and bring other disciplines, such as genetics, into the toxicology research. Collectively, the linkage of toxicogenomic data to specific sites within tissues and specific cellular populations in affected tissues should result in better selection of appropriate animal models, reduction in the number of animals used, and enhanced insight into pathways of toxicity and disease processes that have been heretofore unattainable, ultimately enhancing risk assessment. #311 1:30 ADVANCING TOXICOLOGY BY IMPROVING LINKAGE OF TRADITIONAL TOXICITY AND PATHOLOGY ENDPOINTS WITH TOXICOGENOMICS. I. Rusyn1 and R. Paules2. 1University of North Carolina at Chapel Hill, Chapel Hill, NC and 2National Center for Toxicogenomics, NIEHS, Research Triangle Park, NC.
up-to-date information at www.toxicology.org 83
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, C. Schwab V. M. and V. 1 SCREENING Annual Meeting Annual th S. B. Pruett S. B. . L. Burns Naas
SOT's 45 SOT's Worldwide Safety Sciences, Pfizer Safety Sciences, Worldwide 1 . 2 Molecular Virology, Immunology & Medical Immunology Virology, Molecular 2
Sanders ASSAYS TO PREDICT HUMAN SENSITIVITY. PREDICT HUMAN TO ASSAYS Global Research & Development, San Diego, CA San Diego, Global Research & Development, . Molecular Virology and Immunology, and Immunology, Virology . Molecular M. Sanders V. Columbus, OH. The Ohio State University THE AND PREDICTING MODELING IMMUNOLOGICAL EFFECTS OF INDUCED STRESS AND DRUG CHEMICAL RESPONSES IN MICE. LA. and NON-IMMUNE MECHANISMS FOR THE LEVEL OF IMMUNITY. REGULATING and Diagnosis, National Cancer Institute, Bethesda, and Diagnosis, National S. Green Sponsor: MD. IN VITRO AN IN THE USE OF INDIRECT MECHANISMS OF TOXICITY: TOXICITY: INDIRECT MECHANISMS OF OUR UNDERSTANDING ADVANCING – IMMUNE OF NEUROENDOCRINE INTERACTIONS. and Q. Zheng. Cell. Biol. & and Q. Myers P. R. Fan, Shreveport, LSU Health Sciences Center, Anatomy, J. E. Tomaszewski. Division of Cancer Treatment Treatment of Cancer Division Tomaszewski. E. J. Medical Center, The Ohio State University Genetics, Columbus, OH.
(Continued) Annual Annual th Neurotoxicology SS Neurotoxicology Women in Toxicology SS Toxicology in Women Immunotoxicology SS Immunotoxicology There is overwhelming There evidence that is cytokines, overwhelming neuropeptides, neurotrans #325 2:30 1:30 PM to 4:30 PM Room 6E MECHANISMS OF INDIRECT SYMPOSIUM SESSION: OF OUR UNDERSTANDING ADVANCING TOXICITY: INTERACTIONS NEUROENDOCRINE-IMMUNE & Ann Burns-Naas, Pfizer Global Research Chairperson(s): Leigh Ohio State University, Sanders, Virginia CA and San Diego, Development, OH. Columbus, by: Endorsed Monday, March 6 March Monday, #322 3:55 mitters, and hormones, as wellinter-regulated part as of theirthe central receptors,nervous system, the are andendocrine an system, the integralimmune andsystem. Immune hormonescells synthesizeand neurotransmitters,and secrete system) peptide which and paracrinecan have(endocrine autocrine tionally, and nervenervous (immune terminals systems) containingeffects. neurotransmittersAddi in lymphoidhave beentissues found in close neurotransmitter is released associationwhen an antigen insult is Also, present. recep with lymphoid cells,tors for and neuropeptides,the neurotransmitters, and lymphoid hormonescells. These are findingspresent make on it reasonable chemicalsto suspectmay exertthat some their immunomodulatoryimmune effects system,indirectly by on actingthe to endocrine systems. It modulateis now critical that we begin to the address the probable activity of role played by the neuroendocrine-immune interactions in nervousa chemical-induced or immune toxicity that multiple may involve organ The systems. goal of this symposium is to describe advances in our understanding of the role of the and human health. neuroendocrine-immune axis in chemical toxicity #323 1:30 #324 1:50 45 84
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Environmental Health Environmental 1 . 2 . . Biomedical Sciences and . MatTek Corp., M. Klausner. MatTek
and S. Green
1 M. Ehrich . Office of the Director, A. Casciano. Office of the Director, D. Pharmacology, Howard University, Washington, Washington, University, Howard Pharmacology, 2 SYSTEMS AND THEIR USE IN TOXICOLOGY. IN USE THEIR AND SYSTEMS TOXICITY TESTING USING STEM CELL TESTING USING STEM CELL TOXICITY ASSYAS. and DC. VITRO USE OF HUMAN CELL LINES FOR IN STUDIES. A. Goldberg Kaluzhny, Y. Ayehunie, S. Kubilus, Hayden, J. J. P. E. Sheasgreen and J. NCTR, Jefferson, AR. NCTR, Jefferson, Sciences, John Hopkins University, Baltimore, MD Sciences, John Hopkins University, IN VITRO OF IN THE BIOLOGICAL MATRIX Ashland, MA. Ashland, TOWARDS “ANIMAL-ON-A-CHIP”: M. L. Shuler. TOXICOLOGY. PREDICTIVE Ithaca, Biomedical Engineering, Cornell University, Sponsor: S. Green NY. Pathobiology, Virginia Tech, Blacksburg, VA. Blacksburg, Tech, Virginia Pathobiology, 3-D OF RECONSTRUCTED APPLICATIONS TOXICOLOGY. IN MODELS TISSUE VITRO IN
45th Annual Meeting and ToxExpo and Meeting Annual 45th
SS*
Risk Assessment SS Risk National Capital Area Chapter Area National Capital SS Evaluation Regulatory and Safety In Vitro In The basic biological unit of toxicology, years,as ithas evolved been over thethe laboratorylast 100 introduced rodent. by McCollum E.V. for Thenutritional studies laboratorythe early part rodentof the last was century. For some 50 first years, the animal was not standardized, and was the largest variable in any animal based wasresearch Athe significantstandardization advance of thethe formationlaboratory of Charlesrodent River byLaboratories Henryto the provide Fostersame animals from andthat order are to order. By standardizing became possible for laboratories thein Europe, the United States, and laboratoryJapan to rodent, it actually be able to reproduce studies and know that the potentially largest the variable, animal, The was controlled. now advances made with animals has significantly the improved health of both animals and humans popula #321 3:20 #318 1:35 : Alan Goldberg, Johns Hopkins University, Baltimore, MD Baltimore, Hopkins University, Johns Goldberg, Alan Chairperson(s): DC. Washington, University, Howard Green, and Sydney by: Endorsed Room 7B OF THE BIOLOGICAL MATRIX SYMPOSIUM SESSION: Monday, March 6 March Monday, 1:30 PM to 4:30 PM tions, resulting in an life expanded span As and an enhanced quality of life. science and advanced more specific questions could be asked- experiments to understand mechanisms and mode of action and studies aimed at subcel lular and molecular components of cells- it became necessary to culture learn cells to (both human and animal) to further understandthe effects of drugs biology and many chemicals new and and on their Today, function. exciting approaches are for available the scientist - from using monolayers of cells to three-dimensional reconstituted tissues, to allowing multiple the cell understanding types of the interaction between complex These systems.newer systems and different biological matrixes offer the opportu nity to advance science and our understanding of the by underlying yet biology another step. This symposium presents some of these systems studies. and focuses on their use in toxicological #317 1:30
SYSTEMS AND THEIR USE IN TOXICOLOGY THEIR USE IN AND SYSTEMS VITRO Program Description Description Program #320 2:45 #319 2:10
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #326 3:10 IMPACT OF PSYCHOLOGICAL AND #329 1:35 COMPARATIVE PATHOLOGY OF ENVIRONMENTAL FACTORS ON ASTHMA: HEMANGIOSARCOMA. D. E. Malarkey. FROM ENVIRONMENT TO BENCH TO National Institute of Environmental Health Sciences, BEDSIDE. G. D. Marshall. Medicine, University of Research Triangle Park, NC. Sponsor: D. Pegg. Mississippi Medical Center, Jackson, MS. Sponsor: L. Burns-Naas. #330 2:05 INDUCTION OF HEPATIC HEMANGIOSARCOMA BY VINYL #327 3:50 CHILDREN’S HEALTH RISK - CAN CHLORIDE: DOSE-RESPONSE AND MODE ECONOMIC INEQUALITIES IMPACT THE OF ACTION. J. A. Swenberg. Environmental NEUROIMMUNE INTERFACE AND HEALTH? Sciences and Engineering, University of North D. A. Lawrence, N. Pabello and J. Kasten-Jolly. Carolina, Chapel Hill, NC. Wadsworth Center, Albany, NY. #331 2:35 EPIGENETIC MECHANISMS OF HEMANGIOSARCOMA INDUCTION. J. E. Monday, March 6 Klaunig. Pharmacology and Toxicology, Indiana 1:30 PM to 4:30 PM University, Indianapolis, IN. Room 2 #332 3:05 INVESTIGATIVE APPROACHES TO SYMPOSIUM SESSION: MODE OF ACTION ASSOCIATED UNDERSTANDING THE MODE OF ACTION WITH INDUCTION OF ENDOTHELIAL CELL TUMORS— AND HUMAN RELEVANCE OF PPARγ HEMANGIOSARCOMA AGONIST INDUCED HEMANGIOSARCOMAS IN MICE. R. D. Storer. Safety Assessment, Merck Chairperson(s): David Pegg, Pfizer Global Research & Development, Ann Research Laboratories, West Point, PA. Arbor, MI and Brian Short, Allergan, Inc., Irvine, CA. #333 3:35 REGULATORY PERSPECTIVE ON Endorsed by: PEROXISOME PROLIFERATOR-ACTIVATED Carcinogenesis SS* RECEPTOR (PPAR) INDUCED TUMORS Mechanisms SS INCLUDING HEMANGIOSARCOMA. J. D. Regulatory and Safety Evaluation SS ElHage. Division of Metabolic and Endocrine Drug Toxicologic and Exploratory Pathology SS Products, Food and Drug Administration, Rockville, MD. Hemangiosarcoma is an aggressive, malignant tumor of endothelial cells that is rare in humans. In the 12 regions of the US National Cancer #334 4:05 EPIGENETIC MODE OF ACTION ASSOCIATED WITH INDUCTION OF
Institutes Surveillance, Epidemiology, and End Results (SEER) data- MONDAY base, the incidence rate of hemangiosarcoma between 1996 and 2000 HEMANGIOSARCOMA IN MICE. D. G. was 0.21 new cases per 100,000 people (0.00021%). Hemangiosarcoma Pegg, Z. Wojcinski, K. Criswell, J. Herman and T. in humans commonly occurs on head and neck and is associated with Anderson. World Wide Safety Sciences, Pfizer, Ann skin structures. Liver hemangiosarcoma is associated with exposure to Arbor, MI. genotoxic compounds such as Thorotrast or vinyl chloride. In contrast, hemangiosarcoma occurs spontaneously in liver, spleen, bone marrow, lymph nodes and skin at a high incidence in rodents. The background incidence in B6C3F1 mice reported from the National Toxicology Program database is 5.4% in males and 2.7% in females with a range from 0% to 12%. The incidence in Wistar rats ranges from 0 to 3.4 %. These data suggest that mice are more susceptible to development of spontaneous hemangiosarcoma than rats and much more susceptible than humans. Hemangiosarcoma in rodents, primarily mice, has been reported in the labeling of a number of marketed drug products and in the literature with several chemicals. Some of these compounds dem- onstrated genotoxic potential in nonclinical testing and thus a plausible mechanism for tumor induction involving DNA adduct formation. Oth- ers, however, are clearly nongenotoxic and a mode of action is more difficult to establish. Regardless, findings of hemangiosarcoma have significant impact on decisions made regarding further development of these agents and future usage. Recent research has provided a great deal of information on epigenetic processes of tumorigenesis involving oxidative stress, altered gene expression and species differences related to endothelial homeostasis that provide a basis for risk assessment. #328 1:30 MODE OF ACTION ASSOCIATED WITH INDUCTION OF ENDOTHELIAL CELL TUMORS - HEMANGIOSARCOMA. D. G. Pegg1 and B. Short2. 1World Wide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, MI and 2Drug Safety Evaluation, Allergan, Inc., Irvine, CA. up-to-date information at www.toxicology.org 85 - -
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N. H. N. Annual Meeting Annual and S. M. Lasley . Biomedical and 1 th D. Cory-Slechta D. E. Tiffany-Castiglioni E. SOT's 45 SOT's M. E. Gilbert
. Environmental . Environmental Cory-Slechta D. MODELS OF NEURAL RESPONSES Biomed Therap Sciences, University of Sciences, University Therap Biomed 2 R. B. Mahammad and R. B. Neurotoxicology, U.S. EPA, Research Triangle Park, Park, Triangle Research EPA, U.S. Neurotoxicology, NC and Zawia 1 TO LEAD (PB). TO COMBINED PB EXPOSURE AND AND COMBINED PB EXPOSURE STRESS: ENVIRONMENTAL THE AND THE CNS FOR CONSEQUENCES AXIS. HPA Environmental and Occupational Medicine, Environmental and Occupational Health Sciences Environmental Jersey, Med. Dent New Institute, University NJ. Piscataway, EXPOSURE DEVELOPMENTAL CHRONIC HIPPOCAMPAL LEAD (PB) IMPAIRS TO FUNCTION. of Rhode Pharmaceutical Sciences, University Kingston, RI. Island, and Occupational Medicine, Environmental and Environmental and Occupational Medicine, Institute, University Occupational Health Sciences NJ. Piscataway, Jersey, Med. Dent New ADULT IN CNS EFFECTS OF LEAD NEW EVIDENCE FROM HUMANS: STUDIES OF LONGITUDINAL AND FUNCTION NEUROBEHAVIORAL MRI. STRUCTURAL and Y. Zheng. Integrative Biosciences, Texas A&M Texas Biosciences, Zheng. Integrative Y. and TX. Station, College University, ALZHEIMER’S DISEASE. AND PB Illinois, Peoria, IL. Illinois, Peoria, VITRO IN
(Continued) Annual Annual th Mechanisms SS* Tight Tight regulation of cell death and survival is and the development maintenance Tissue of or tissue homeostasis. turnover key for normal embryonic homeostasis occurs when a andbalance cell isdeath soachieved that betweenno net at least in part,apoptosis. Conse by homeostatic cell celldeletion is controlled, change in renewal cell number is present. Normal 1:30 PM to 4:30 PM Room 8 MECHANISMS NEW INSIGHTS INTO SYMPOSIUM SESSION: AND SURVIVAL OF CELL DEATH of Kansas Medical Center, Robertson, University Chairperson(s): John Austin, Austin, at Texas of University KS and Shawn Bratton, Kansas City, TX. by: Endorsed #336 1:45 #338 2:55 6 March Monday, quently, dysregulation of apoptotic cell death has been implicatedonset of numerous in pathologies, including the liver and autoimmune disorders, cardiovascular disease, and cancer. Further,contribute to an increased risk environmentalof these diseases appear to do so, at factorsleast in that part, by disrupting the balance between cell death and survival. Likewise, preventive and therapeutic measures to control designed to these block aberrantdiseases cell death are or survival. oftenWhether a cell survives or dies in the presence of a toxic stimulus is often determined by prolifera tive status, repair enzyme and/or capacity, the ability to induce or activate proteins that either promote or inhibit apoptotic cell death. underlying Althoughmolecular and the biochemical mechanisms, in some cases, are at least partially understood, in many other instancesThis they symposiumremain willunclear. present important regulating cell death or in survival response a to diverse With stimuli. toxic new insights into mechanisms #337 2:15 #340 3:55 #339 3:25 45 86 - - - - - Meeting & ToxExpo & Meeting , D. , D. 4 1 . 5 Veterinary Veterinary 3
L. White L. University University 5 M. E. Gilbert , Occupational and 6 6 N. H. Zawia and N. 3 B. S. Schwartz , B. 2 Neurotoxicology Division, U.S. U.S. Division, Neurotoxicology 4
NCEA, U.S. EPA, Research Triangle Park, NC, Park, Triangle Research EPA, NCEA, U.S. and Occupational Health Sciences Environmental A. Cory-Slechta 1 2 of Medicine and Dentistry of Institute, University NJ, and Rutgers, Piscataway, Jersey New Environmental Health, Johns Hopkins University, Health, Johns Hopkins University, Environmental Baltimore, MD. Rhode Island, Kingston, RI and Rhode Island, EPA, Research Triangle Park, NC, Park, Triangle Research EPA, NEW CONCEPTS IN THE NEW CONCEPTS IN OF LEAD. NEUROTOXICOLOGY Anatomy and Public Health, Texas A&M, College A&M, College Texas Health, and Public Anatomy TX, Station, E. C. Tiffany-Castiglioni E. C.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Neurotoxicology SS* Neurotoxicology Metals SS Risk Assessment SS Risk Lead is a xenobiotic metal with no historically known function in cellular growth, proliferation, or signaling. Decades of research characterizing the toxicology of lead have shown it to be a potent neurotoxicant, during nervous especially system development. New concepts in the neurotoxicology of lead include advances in understanding specificitythe mechanisms of and lead.cellular Environmental factors such as stress and socioeco : Lori White, U.S. EPA, Research Triangle Park, NC and Park, Triangle Research EPA, U.S. White, Chairperson(s): Lori of Medicine and Dentistry of New University Cory-Slechta, Deborah NJ. Piscataway, Jersey, by: Endorsed Room 6B THE IN NEW CONCEPTS SYMPOSIUM SESSION: OF LEAD NEUROTOXICOLOGY Monday, March 6 March Monday, 1:30 PM to 4:30 PM esis in hippocampus is also impacted by Pb exposure. The action of on lead glutamate release, NMDA receptor function, or growth factor sionexpres may underlie perturbations in synaptic learning impairments. Evidence plasticityis also mounting that lead andcan accumulate contribute to in astroglial cells by utilizing the cellular transport systems normally used for essential minerals such as calcium. Additionally, glial glucose cells regulated may proteinuse (GRP78), a molecular chaperoneplasmic reticulum, in to temporarily the bind endo lead during the lead accumulation process. this However, binding may contribute to increased susceptibility of the brain to stress, as GRP78 is also a stress protein and a chaperone for interleukine-6. Lead exposure in early life has been implicated quent in progression subse of Alzheimers Disease (AD) in rodents. This exposure caused upregulation of mRNA coding for beta-amyloid precursor protein, which is cleaved into beta-amyloid peptides associated causally with AD. This new body of research presents compelling low evidence exposuresthat even of very lead have adverse effects and genetic factors increase environmental nervous system susceptibility to on the nervous system, that in later life. life cause neurodegeration in early and that exposures lead, #335 1:30
nomic status have been shown to potentiate elevated the glucocorticoideffects of levels lead actingthrough on New structural theMRI studies shown relationships have of lead mesocorticolimbicto alterations system. in CNS and of volumes and matter to white severity lesions. the prevalence Cellular models of learning and memory have been utilized to investigate the potential mechanisms of Pb-induced deficits.cognitive Examination of long-term potentiation in the rodent hippocampus has revealed Pb-induced increases in threshold, decreases in magnitude, and shorter retention times of synaptic plasticity. Structural plasticity in the form of adult neurogen Program Description Description Program
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) combination of perspectives, this session will appeal broadly to those who hypotheses on the mechanisms of action of asbestos toxicity. In the area are interested in studies of the molecular and biochemical mechanisms of of asbestos exposure assessment, improvements in analytical and counting cell death and survival. methodologies will be discussed. This presentation will also provide some #341 1:30 NEW INSIGHTS INTO MECHANISMS OF preliminary results of a sensitivity analysis being conducted by EPA on a CELL DEATH AND SURVIVAL. J. D. Robertson1 quantitative cancer model that divides asbestos fibers into four bins (diam- and S. B. Bratton2. 1Pharmacology, Toxicology & eter < .4um), as a function of mineral type (chrysotile versus amphiboles), Therapeutics, University of Kansas Medical Center, and length (5-10um, > 10 um). EPA has been working to establish quantita- Kansas City, KS and 2Division of Pharmacology tive uncertainty bounds around the fitted model parameter estimates and and Toxicology, The University of Texas at Austin, performing sensitivity analyses to help characterize confidence in these Austin, TX. values. The preliminary results for lung cancer indicate that confidence in the fitted parameters shows that the best results are obtained for the #342 1:35 TOPOISOMERASE II INHIBITORS AND potency values for the long fibers, as compared to the potency values for CELL DEATH. J. D. Robertson, P. Bu and E. E. shorter fibers. Franklin. Pharmacology, Toxicology & Therapeutics, #347 1:30 ADVANCES IN ASBESTOS TOXICOLOGY University of Kansas Medical Center, Kansas City, AND EXPOSURE ASSESSMENT. E. L. KS. Hofmann1, A. Koppikar2, M. Maddaloni3, A. 2 1 1 #343 2:10 MITOCHONDRIAL AND POST- Koppikar , E. L. Hofmann , E. Kuempel , T. 4 5 3 1 MITOCHONDRIAL PROSURVIVAL Hei , J. Verkouteren and M. Maddaloni . Office MECHANISMS IN SRTESSED CELLS. of Solid Waste and Emergency Response, U.S. 2 D. G. Tang, J. Liu, G. Choy and D. Chandra. EPA, Washington, DC, Office of Research and 3 Carcinogenesis, The University of Texas MD Development, U.S. EPA, Washington, DC, Region 4 Anderson Cancer Center, Smithville, TX, TX. 2, U.S. EPA, New York, Columbia University, 5 Sponsor: S. Bratton. New York and National Institute of Standards and Technology, Rockville, MD. #344 2:45 NOVEL MECHANISMS OF HEAT SHOCK- INDUCED APOPTOSIS. S. B. Bratton and R. S. #348 2:00 ASBESTOS NONCANCER EFFECTS Milleron. Division of Pharmacology and Toxicology, - INTEGRATED RISK INFORMATION The University of Texas at Austin, Austin, TX. SYSTEM (IRIS)UPDATE. A. Koppikar. ORD/ NCEA-W, U.S. EPA, Washington, DC. Sponsor: E. #345 3:20 BOTH BID-DEPENDENT AND BID- Hofmann. INDEPENDENT APOPTOTIC PATHWAYS ARE INVOLVED IN TNFα-INDUCED #349 2:30 FIBER SIZE-SPECIFIC EXPOSURE HEPATOCYTE APOPTOSIS. X. Yin, W. Ding, H. ESTIMATES AND UPDATED MORTALITY MONDAY Ni and X. Chen. Pathology, University of Pittsburgh ANALYSIS OF CHRYSOTILE ASBESTOS 1 Shool of Medicine, Pittsburgh, PA. Sponsor: J. TEXTILE WORKERS. E. D. Kuempel , L. T. 2, 1 3 1 Robertson. Stayner , J. D. Dement , S. J. Gilbert and M. J. Hein1. 1National Institute for Occupational Safety #346 3:55 STEROID HORMONE INDUCED and Health, Cincinnati, OH, 2University of Illinois, CELL SURVIVAL RESPONSE IN Chicago, IL and 3Duke University Medical Center, CARDIOMYOCYTES. Q. M. Chen, H. Sun, Durham, NC. Sponsor: L. Hofmann. S. Morrissy, L. Xie, Y. Lin and D. Alexander. Pharmacology, University of Arizona, Tucson, AZ. #350 3:00 MECHANISMS OF FIBER CARCINOGENESIS: FROM MITOCHONDRIAL DAMAGE TO SILENCING Monday, March 6 OF THE BIGH3 GENE. T. K. Hei1, 2. 1Center for 1:30 PM to 4:30 PM Radiological Research, Columbia University, New Room 15A York, NY, NY and 2Environmental Health Sciences, Columbia University, New York. Sponsor: E. WORKSHOP SESSION: ADVANCES IN ASBESTOS TOXICOLOGY Hofmann. AND EXPOSURE ASSESSMENT #351 3:30 AN OVERVIEW OF ASBESTOS COUNTING Chairperson(s): Elizabeth Lee Hofmann, U.S. EPA, Washington, DC and TECHNOLOGIES. J. Verkouteren. NIST, Mark Maddaloni, U.S. EPA, New York, NY. Gaithersburg, MD. Sponsor: E. Hofmann. Endorsed by: #352 4:00 ASSESSING ASBESTOS HAZARDS IN THE Risk Assessment SS INDOOR ENVIRONMENT. M. A. Maddaloni. U.S. EPA, New York. Occurrences of asbestos-related contamination, such as the vermiculite mine in Libby, Montana, and the World Trade Center, have highlighted the need to update the state of science with regard to asbestos toxicity and exposure assessment. The purpose of this workshop is not only to provide an overview for toxicologists, but also to highlight the advances in a number of important areas. Recent work by U.S. EPA in examining the carcinogenic and non-carcinogenic effects of asbestos will be presented. The technical issues of assessing asbestos hazard in an indoor environ- ment are presented. New data from NIOSH will update the dose-response analysis of the mortality of textile workers. Research into cellular and molecular mechanisms of lung and pleural diseases is opening up new up-to-date information at www.toxicology.org 87 ,
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1 , L. Haldosen , C. Gaul 1 3 , B. Wihlen , B. 1 , L. Haldosen 1 Department of Biosciences, Wildlife Ecology, University of University Ecology, Wildlife 1 1 . SOT's 45 SOT's . 1 Department of Biosciences, 4 1 MRPath Inc., Durham, NC and MRPath 3 . , L. K. Prahl 1 2 , L. Helguro , B. Johnson , B. 1 and G. T. Knipp. Department of T. Xu and G. , Y. 3 J. Matthews J. , L. Helguro 1 TO CYP1A1 BY BNF, ICZ, AND DIM AND AND DIM ICZ, BNF, CYP1A1 BY TO α Laboratory of Experimental Pathology, NIEHS/ Laboratory of Experimental Pathology, Medical Nutrition, Karolinska Institutet, Huddinge, Medical Nutrition, Karolinska Medical Nutrition, Karolinska Institutet, Huddinge, J. Gustafsson J. Wisconsin - Madison, Madison, WI, - Madison, Madison, Wisconsin NIH/DHHS, Research Triangle Park, NC. Park, Triangle NIH/DHHS, Research MESENCHYMAL STEM PB REGULATES WAY A CELL GENE EXPRESSION IN EXPLAIN ITS EFFECTS ON MAY THAT GROWTH. SKELETAL Sweden. PCB104 INDUCES NOT BUT PCB126, OF ER RECRUITMENT Sweden. P. T. Johnson T. P. 4 DI-(2-ETHYLHEXYL)-PHTHALATE DI-(2-ETHYLHEXYL)-PHTHALATE THE FETAL IN AFFECTS LIPID PROFILING BRAIN UPON IN UTERO RAT M. Brooks, D. Greenwell, Coffin, R. J. MICE. J. Beall L. G. Calderon and H. D. COMBINED EFFECTS OF CADMIUM INFECTION ON PARASITE AND (CD) AMPHIBIAN MALFORMATIONS. Guenther and K. Johnson THE DIFFERENTIAL RECRUITMENT OF RECRUITMENT THE DIFFERENTIAL ER Matthews and J. 2 GENES. Treuter E. 2 J. Zuscik, E. M. Schwarz, R. N. Rosier and R. J. Rosier and R. J. R. N. Zuscik, E. M. Schwarz, J. Department of of Orthopaedics,O’Keefe. University NY. Rochester School of Medicine, Rochester, Enviromental Health Sciences, University of Health Sciences, University Enviromental Montana, Missoula, MT. IMAGING RESONANCE MAGNETIC IN TOOL INVASIVE A NON- AS TOXICOLOGY: DEVELOPMENTAL THE IMPORTANT ROLE OF ER ROLE THE IMPORTANT and Karolinska Institute, Huddinge, Sweden of The State University Pharmaceutics, Rutgers, NJ. Piscataway, Jersey, New CAUSES DYSMORPHOGENESIS VASCULAR AND INSUFFICIENCY PLACENTAL ARSENIC EXPOSED MISCARRAIGE IN B. Wihlen B. TRANSCRIPTION. T. J. Cook J. T. Limnology, University of Wisconsin - Madison, Wisconsin of University Limnology, WI, Madison, Treuter and Sweden Karolinska Institute, Huddinge,
(Continued) Annual Annual th #365 2:30 #361 4:10 6 March Monday, Room 5A VIVO IN TOXICITY DEVELOPMENTAL SESSION: PLATFORM INVESTIGATIONS VITRO AND IN of School of Rochester Puzas, University Edward Chairperson(s): Protection Environmental Abbott, NY and Barbara Rochester, Medicine, NC. Park, Triangle Research Agency, #362 1:30 #360 3:50 1:30 PM to 4:30 PM #364 2:10 #363 1:50 45 88 , , Meeting & ToxExpo & Meeting 1 S. , L. 2
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D. Michael and D. 1 2 , A. Pandini , 1 di Scienze e del Territoria, Universita degli Studi di degli Universita Territoria, di Scienze e del . Biology, University of University . Biology, and R. S. Pollenz Wilson FL. Tampa, South Florida, AND OTHER 3-METHYLCHOLANTHRENE RECEPTOR HYDROCARBON ARYL ACTIVATE DIRECTLY AGONISTS ALPHA. RECEPTOR ESTROGEN Toxicology, University of California, Davis, CA and of California, Davis, University Toxicology, . Biomedical Sciences, Division of Cancer E. Eltom. Biomedical Sciences, Division TN. Meharry Nashville, Medical College, Biology, Barhoumi Bonati CA and Davis, UCDavis, MICE. University of Pharmacy, . College Walker and M. K. NM. Albuquerque, Mexico, of New HSP90-BINDING OF CHARACTERIZATION OF ROLE CENTRAL RECEPTOR, AH THE TO A. Soshilov DOMAIN. THE PASB Song and L. Bonati 2 Milano-Bicocca, Milano, Italy. INCREASE IN ENDOTHELIN-1-MEDIATED AND NAD(P)H SPECIES OXYGEN REACTIVE ARYL OF IN HEARTS ACTIVITY OXIDASE (AHR) NULL RECEPTOR HYDROCARBON DIFFERENTIAL RESPONSIVENESS OF THE OF DIFFERENTIAL RESPONSIVENESS PAHS. AND HAHS TO AH RECEPTOR Cancer Center, Philadelphia, PA. Cancer Center, OF TRANSFORMATION MALIGNANT EPITHELIAL CELLS BY MAMMARY ARYL THE OF OVER-EXPRESSION RECEPTOR. HYDROCARBON e del Territoria, Universita degli Studi di Milano- degli Universita Territoria, e del Bicocca, Milano, Italy. OF ENDOGENOUS XAP2 IN THE ROLE AND THE SUBCELLULAR LOCATION SHUTTLING OF NUCLEOCYTOPLASMIC AH THE ENDOGENOUS D. Hill D. Environmental Toxicology, University of California, University Toxicology, Environmental CA. Davis, AND HOMOLOGY MODELING AHR MOUSE THE OF MUTAGENESIS LIGAND BINDING DOMAIN. Abdelrahim A&M University, Houston, TX and Houston, A&M University, J. E. Bohonowych J.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
#358 3:10 #356 2:30 #355 2:10 1:30 PM to 4:30 PM Room 7A II AH RECEPTOR SESSION: PLATFORM Davis, Davis, of California Denison, University Michael Chairperson(s): NM. Albuquerque, Mexico, of New University Walker, CA and Mary #353 1:30 Monday, March 6 March Monday, #359 3:30 #357 2:50
#354 1:50 Program Description Description Program
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #366 2:50 DEVELOPMENT OF CATARACT #372 1:50 MODULATION OF ALLERGIC ASTHMA PHENOTYPE IN ALDH1A1-/-/ALDH3A1- BY OAK DUST EXPOSURE IN MICE. K. /- DOUBLE KNOCKOUT MICE. N. Lassen1, Savolainen1, J. Maatta1, M. Lehto1, M. Leino1, W. Black1, J. Kuszak2, B. Bateman3, D. Nees4, S. Tillander1, R. Haapakoski1, H. Wolff2 and H. J. Piatigorsky4, G. Duester5 and V. Vasiliou1. Alenius1. 1Industrial Hygiene and Toxicology, 1Pharmaceutical Sciences, UCHSC, Denver, Finnish Institute of Occupational Health, Helsinki, CO., 2Ophthalmology and Pathology, Rush- Finland and 2Occupational Medicine, Finnish Presbyterian-St. Luke’s Medical Center, Chicago, Institute of Occupational Health, Helsinki, Finland. IL, 3Ophthalmology and Pediatrics, Rocky Mountain Lions Eye Institute, Denver, CO., 4Molecular and #373 2:10 EXPOSURE IS THE PROOF OF THE Developmental Biology, NIH, Bethesda, MD and PUDDING: OXAZOLONE IS A POTENTIAL 5OncoDevelopmental Biology Program, Burnham RESPIRATORY ALLERGEN. C. Mommers, J. Institute, La Jolla, CA. Arts, M. Schijf and F. Kuper. TNO Quality of Life, Zeist, Netherlands. Sponsor: V. Feron. #367 3:10 REDUCED INCIDENCE OF VALPROIC ACID INDUCED NEURAL TUBE DEFECTS WITH #374 2:30 CYTOKINE RESPONSES TO DERMAL MATERNAL IMMUNE STIMULATION. ISOCYANATE EXPOSURE IN DRAINING T. C. Hrubec1, 2, K. A. Toops2, M. Yang3, K. Ye3 LYMPH NODES ARE NOT PREDICTIVE and S. D. Holladay2. 1Department of Biomedical OF AIRWAY RESPONSES AFTER AIRWAY Sciences, VA College of Osteopathic Medicine, CHALLENGE. A. K. Farraj, E. H. Boykin, N. Blacksburg, VA, 2Department of Biomedical Haykal-Coates, S. H. Gavett and M. K. Selgrade. Sciences and Pathobiology, VA-MD Regional Experimental Toxicology Division, U.S. EPA, College of Veterianry Medicine, Blacksburg, VA and Research Triangle Park, NC. 3 Department of Statistics, VA Tech, Blacksburg, VA. #375 2:50 INITIAL INTERACTIONS OF ALLERGENS #368 3:30 TOWARD DEVELOPMENTAL TOXICOLOGY WITH AIRWAY EPITHELIAL CELLS: ANY IN VITRO: IMPLICATIONS OF GENE ROLE IN THE INDUCTION OF TYPE I 1 2 2 EXPRESSION RESPONSES TO VALPROIC ALLERGY? M. Baccam , N. Soni , L. Fridthjof , 2 1 2 1 ACID IN EMBRYOS AND IN VITRO MODELS. N. Berg , K. Sarlo and E. Roggen . Miami M. Stigson1, K. Kultima1, M. Jergil1, B. Scholz1, Valley Laboratories, Procter & Gamble Company, 2 H. Alm1, A. Gustafson2 and L. Dencker1. Cincinnati, OH and Novozymes, Bagsvaerd, 1Pharmaceutical Biosciences, Uppsala University, Denmark. Uppsala, Sweden and 2Safety Assessment,
#376 3:10 IN VITRO CHARACTERIZATION OF MONDAY AstraZeneca R&D, Sodertalje, Sweden. Sponsor: K. DENDRITIC CELL (DC) RESPONSES TO Ramos. A CHEMICAL ALLERGEN AND A SKIN 1 1 #369 3:50 EFFECTS OF PERFLUOROOCTANOIC ACID IRRITANT. C. Portsmouth , M. Cumberbatch , 1 1 2 (PFOA) ON MICE EXPOSED IN UTERO AT C. Schramm , R. J. Dearman , G. Maxwell , C. 2 2 1 SPECIFIC GESTATIONAL STAGES. B. D. Westmoreland , D. A. Basketter and I. Kimber . 1 Abbott, C. J. Wolf, K. P. Das and C. S. Lau. RTD Immunology, Syngenta CTL, Macclesfield, United 2 (MD67), U.S. EPA/ORD/NHEERL, Research Kingdom and SEAC, Unilever, Bedford, United Triangle Park, NC. Kingdom. #370 4:10 CROSS-FOSTER STUDY OF THE #377 3:30 THE REDUCED LLNA AS A HAZARD DEVELOPMENTAL EFFECTS OF PFOA. C. IDENTIFICATION SCREEN FOR SKIN 1 2 J. Wolf, J. R. Thibodeaux, C. Lau and B. D. Abbott. SENSITISATION. D. A. Basketter , G. Patlewicz , 3 3 4 5 Reproductive Toxicology Division, U.S. EPA/ F. Gerberick , C. Ryan , P. Kern , R. Dearman and 5 1 NHEERL/ORD, Research Triangle Park, NC. I. Kimber . SEAC, Unilever, Sharnbrook, United Kingdom, 2European Chemicals Bureau, Ispra, Italy, 3P&G, Cincinnati, OH, 4P&G, Brussels, Belgium Monday, March 6 and 5Syngenta CTL, Macclesfield, United Kingdom. 1:30 PM to 4:30 PM Room 5B #378 3:50 EVALUATION OF THE PERFORMANCE OF CANDIDATE GENES FOR PREDICTING PLATFORM SESSION: HYPERSENSITIVITY SKIN SENSITIZATION POTENTIAL. L. Gildea1, C. A. Ryan1, L. Foertsch1, J. Kennedy1, R. Chairperson(s): Katherine Sarlo, Procter & Gamble Company, Cincinnati, Dearman2, I. Kimber2 and G. Gerberick1. 1Procter OH and David Basketer, Unilever, Bedford, United Kingdom. & Gamble Company, Cincinnati, OH and 2Syngenta #371 1:30 CATALASE FROM A FUNGAL MICROBIAL Central Toxicology Laboratory, Macclesfield, United PESTICIDE INDUCES A UNIQUE IGE Kingdom. RESPONSE. M. D. Ward1, L. B. Copeland1, M. J. Donohue2, Y. Chung1, J. A. Shoemaker2 and S. J. Vesper2. 1NHEERL, U.S. EPA, Research Triangle Park, NC and 2NERL, U.S. EPA, Cincinnati, OH.
up-to-date information at www.toxicology.org 89
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1 Vrije 1 Stockholm 2 Lund . 4 1 N. Berdasco N. , P. Sauer , P. 5 BGFA, Klinische Klinische BGFA, 3 Annual Meeting Annual , A. Gutleb , State University State University th National University National University 2 . 6 5 , C. Regan 4 . and A. Brouwer 1 SOT's 45 SOT's , A. Bergman 1 , L. Hagmar 3 , J. Legler , J. 7 University, Uppsala, Sweden. University, THE NEW IARC MONOGRAPHS: EFFECTS OF 3 WEEK EXPOSURES TO TO WEEK EXPOSURES EFFECTS OF 3 SODIUM ON REPRODUCTIVE METAM A. S. Murr, THE FEMALE RAT. FUNCTION IN . College of Law, Arizona State University, Arizona State University, of Law, . College Marchant AZ. Tempe, TRIPROPYL TRIETHYL PHOSPHATE, PHOSPHATE: TRIBUTYL AND PHOSPHATE, AND CLASS ASSESSMENT ORAL RISK LEVEL. EVALUATION BASED and D. I. McCready. Toxicology and Environmental and Environmental Toxicology I. McCready. and D. Chemical The Dow Research and Consulting, MI. Midland, Company, CHILDREN’S PESTICIDE EXPOSURE WE GO FROM WHERE DO STUDIES: Environmmental A. Fenske. “CHEERS”? R. WA. Seattle, Washington, of Health, University Kavanagh Sponsor: T. M. Goldman. Endocrinol. Br., R. L. Cooper and J. Triangle Research EPA, U.S. NHEERL, ORD, RTD, NC. Park, C. Buitenhuis Lilienthal I. Brandt Netherlands, Amsterdam, University, and Groningen, Groningen, Netherlands R. Baan, K. Straif, Cogliano, J. V. PREAMBLE. El Ghissassi. Secretan and F. Grosse, B. Y. Lyon, for Research on Cancer, Agency International Sponsor: C. Portier France. of Ireland, Dublin, Ireland, Ireland, Dublin, of Ireland, University, Stockholm, Sweden, Stockholm, Sweden, University, University, Lund, Sweden, Sweden, Lund, University, RISK ASSESSMENT OF HALOGENATED ASSESSMENT OF HALOGENATED RISK SOME AND PHENOLIC COMPOUNDS FLAME RETARDANTS. BROMINATED INCORPORATING GENETIC GENETIC INCORPORATING IN STANDARD- SUSCEPTIBILITY DATA AIR POLLUTANTS. SETTING FOR Arbeitsmedizin, Bochum, Germany, Germany, Arbeitsmedizin, Bochum,
1:30 PM–4:30 PM 1:30 PM–3:00 PM (Continued) Annual Annual th #385 3:10 #389 #387 3:50 #388 4:10 1:30 PM to 4:30 PM Exhibit Hall FEMALE REPRODUCTION POSTER SESSION: A & M, Baton Southern University Naragoni, Chairperson(s): Srivatcha LA. Rouge, Displayed: Attended: Monday, March 6 March Monday, #384 2:50 #386 3:30 45 90 , Meeting & ToxExpo & Meeting 1
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M. Chu George Perkins Perkins George , A. Fedorowicz , 1 1 , 1 . , C. Keshava 1 2 Amvac Chemical Amvac Syracuse Research 5 1 Toxicology Consulting Toxicology B. J. Meade J. , B. J. A. MacGregor , J. 4 . 1 3 P. McClure and P. 2 J. Benedict , J. 1 1 , B. F. Law F. , B. 1 , M. Gelhaus 1 and R. Goble 1 P. D. Siegel D. , P. National Institute for Occupational National Institute for Occupational 2 , C. Keshava 1 1 Integrative Biostrategies LLC, Houston, Biostrategies Integrative . 1 1 and L. Flowers , S. H. Youngren , S. H. 1 . 2 5 L. P. Myers L. P. TBS Associates, Raleigh, NC, TBS National Center for Environmental Assessment, National Center for Environmental 2 2 Department of Medicine, University of Toronto, Toronto, of Department of Medicine, University Marsh Institute, Clark University, Arlington, MA Arlington, Marsh Institute, Clark University, Manley Stickney Corporation, Syracuse, NY and N. Rahmioglu N. TX, DC. THE MAGNITUDE OF DETERMINATION OF INTRASPECIES DIFFERENCES IN RED BLOOD CELL CHOLINESTERASE TO INHIBITION IN RESPONSE EXPOSURE. DICHLORVOS and MODE OF ACTION AND THE INHALATION THE INHALATION AND ACTION MODE OF CARCINOGENICITY OF NAPHTHALENE. USE OF A MULTIDISCIPLINARY APPROACH APPROACH A MULTIDISCIPLINARY USE OF PHENOLIC DERMAL IDENTIFIED THAT CLOSURE WOUND A SENSITIZERS IN TAPE. G. Sussman Beezhold 2 Canada. ON, Toronto, Services, Arnold, MD and Arnold, Services, L. Flowers Safety and Health, Morgantown, WV and Safety and Health, Morgantown, U.S. EPA, Washington, DC, DC and Washington, EPA, U.S. U.S. EPA, Washington, DC. Washington, EPA, U.S. RELATIVE FOR DERIVING APPROACHES FOR FACTORS CARCINOGENIC POTENCY HYDROCARBONS AROMATIC POLYCYCLIC R. McClure P. (PAHS). Science Center, Syracuse Research Corporation, Science Center, Syracuse, NY. IN DIFFERENCES RELATED AGE CARCINOGENESIS—A TO SUSCEPTIBILITY OF CLASSIFICATION PRELIMINARY TO ACTION MODES OF NON-MUTAGENIC OF ANALYSIS QUANTITATIVE STRUCTURE Hattis D. DATA. BIOASSAY Group, Washington, DC, Washington, Group, Corporation, Beach, CA. Newport B. Starr B. Carlson-Lynch Washington, EPA, Assessment, U.S. Environmental
45th Annual Meeting and ToxExpo and Meeting Annual 45th
#383 2:30 POLICY MD and Inc., Gaithersburg, Mattes, Gene Logic William Chairperson(s): WA. Exponent, Bellevue, Yost, Lisa #380 1:30 1:30 PM to 4:30 PM Room 1B ASSESSMENT—REGULATORY/ RISK SESSION: PLATFORM Monday, March 6 March Monday, #379 4:10 Program Description Description Program #382 2:10 #381 1:50
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #390 THE REPORTED ACTIVE METABOLITE #397 ANALYSIS OF GENE EXPRESSION IN RAT OF THE PESTICIDE METHOXYCHLOR OVARIAN FOLLICLES: A COMPARISON (MC), 2, 2-BIS(P-HYDROXYPHENYL)-1, 1, PRIOR TO IN VIVO VS. IN VITRO EXPOSURE 1-TRICHLOROETHANE (HPTE), INHIBITS TO 4-VINYLCYCLOHEXENE DIEPOXIDE. ANDROGEN PRODUCTION BY RAT S. M. Fernandez1, J. B. Hoying2, 1 and P. B. Hoyer1. OVARIAN THECA INTERSTITIAL (TI) 1Physiology, University of Arizona, Tucson, AZ and CELLS. Y. Akgul2, 1, R. C. Derk1 and E. P. Murono1, 2Biomedical Engineering, University of Arizona, 2. 1Pathology and Physiology Research Branch, Tucson, AZ. NIOSH, Morgantown, WV and 2Department of Physiology and Pharmacology, West Virginia #398 COMPARATIVE TRANSCRIPTIONAL, University School of Medicine, Morgantown, WV. MORPHOMETRIC AND UTEROTROPHIC Sponsor: V. Castranova. ASSESSMENT OF ESTROGEN SIGNALLING IN THE RODENT UTERUS. J. C. Kwekel, L. #391 METHOXYCHLOR AND ITS METABOLITES D. Burgoon, J. W. Burt, J. R. Harkema and T. R. INHIBIT GROWTH AND INDUCE ATRESIA Zacharewski. Biochemistry and Molecular Biology, OF ANTRAL FOLLICLES IN BABOON Michigan State University, East Lansing, MI. OVARIES. R. Gupta1, G. Aberdeen2, J. Babus1, E. Albrecht2 and J. Flaws1. 1Toxicology, University #399 GESTATIONAL PFOA EXPOSURE OF of Maryland, Baltimore, MD and 2Obstetrics, MICE IS ASSOCIATED WITH ALTERED Gynecology and Reproductive Sciences, University MAMMARY GLAND DEVELOPMENT IN of Maryland, Baltimore, MD. DAMS AND FEMALE OFFSPRING. S. S. White1, J. L. Rayner2, E. P. Hines3, J. R. Thibodeaux3 #392 METHOXYCHLOR INDUCES ATRESIA and S. E. Fenton3. 1Toxicology, UNC, Chapel Hill, OF ANTRAL FOLLICLES IN ER ALPHA NC, 2ESE, UNC, Chapel Hill, NC and 3Reproductive OVEREXPRESSING MICE. D. Tomic1, J. K. Toxicology Division, NHEERL, ORD, U.S. EPA, Babus1, S. M. Frech2, R. Gupta1, P. A. Furth2, R. Research Triangle Park, NC. D. Koos3 and J. A. Flaws1. 1Program in Toxicology, University of Maryland, Baltimore, MD, #400 FERTILIZATION RATE AND OOCYTE 2Department of Oncology, Lombardi Comprehensive QUALITY IS ADVERSELY AFFECTED Cancer Center, Georgetown University, Washington, FOLLOWING NEONATAL EXPOSURE TO DC and 3Department of Physiology, University of THE PHYTOESTROGEN GENISTEIN. W. N. 1, 3 1 2 Maryland, Baltimore, MD. Jefferson , E. Padilla-Banks , E. H. Goulding , E. M. Eddy2 and R. R. Newbold1. 1Laboratory
#393 ANTI-MULLERIAN HORMONE of Molecular Toxicology, NIEHS, Research MONDAY CORRELATES WITH OVARIAN FOLLICLE Triangle Park, NC, 2Laboratory of Reproductive POPULATIONS IN MICE. P. J. Devine1 and L. and Developmental Toxicology, NIEHS, Research P. Mayer2. 1Institut Armand-Frappier, INRS, Pointe Triangle Park, NC and 3Department of Molecular Claire, QC, Canada and 2Biological Sciences, and Environmental Toxicology, North Carolina State Northern Arizona University, Flagstaff, AZ. University, Raleigh, NC. #394 TCDD ALTERS FOLLICULAR #401 EFFECTS OF GESTATIONAL AND DEVELOPMENT AND STEROIDOGENESIS: NEONATAL EXPOSURE TO GENISTEIN USING THE ZEBRAFISH TO IDENTIFY ON THE DEVELOPMENTS OF OVARY THE MOLECULAR TARGETS OF TCDD’S AND UTERUS IN PREPUBERTAL RATS. S. REPRODUCTIVE TOXICITY. T. King Heiden1, Kim1, R. Lee1, G. Rhee1, S. Kwack1, J. Seok1, K. 2, C. Struble3, M. Hessner4, R. J. Hutz2, 1 and M. Lim1, J. Kang1, J. Chung2, J. Kim2 and D. Cho1. J. Carvan1. 1Great Lakes Water Institute, UW- 1Reproductive & Developmental Toxicology, Milwaukee, Milwaukee, WI, 2Department of National Institute of Toxicological Research, Korea Biological Sciences, UW-Milwaukee, Milwaukee, FDA, Seoul, South Korea and 2Department of WI, 3Department of Mathematics, Marquette Anatomy and Cell Biology, Dong-A University, University, Milwaukee, WI and 4Department Busan, South Korea. Sponsor: J. Hong. of Pediatrics, Medical College of Wisconsin, Milwaukee, WI. #402 VALIDATING A GENE EXPRESSION PROFILE FOR ESTROGENS IN FETAL #395 INVESTIGATION OF THE CELL DEATH OF UTERUS AND OVARIES: TOWARDS AN SMALL PREANTRAL FOLLICLES INDUCED ALTERNATIVE METHOD FOR ENDOCRINE BY DNA-DAMAGING AGENTS IN CULTURED ASSESSMENT. G. Daston, L. Foertsch, G. MOUSE OVARIES. P. Desmeules and P. J. Devine. Overmann, S. Torontali, J. Tiesman, G. Carr, T. INRS-Institut Armand-Frappier, Montréal, QC, Leazer and J. Naciff. Miami Valley Labs, Procter & Canada. Gamble, Cincinnati, OH. #396 IRRITATION TESTING OF CONTRACEPTIVE #403 COMPARATIVE ANALYSIS OF TEMPORAL AND FEMININE-CARE PRODUCTS USING GENE EXPRESSION, MORPHOMETRY EPIVAGINALTM, AN IN VITRO HUMAN AND UTEROTROPHY IN TAMOXIFEN AND VAGINAL-ECTOCERVICAL TISSUE MODEL. ETHYNYLESTRADIOL TREATED RATS. H. S. Ayehunie, J. Kubilus, P. Hayden, C. Cannon, A. Dalgleish, J. C. Kwekel, L. D. Burgoon and T. R. S. Lamore and M. Klausner. R & D, MatTek Zacharewski. Biochemistry and Molecular Biology, Corporation, Ashland, MA. Michigan State University, East Lansing, MI. up-to-date information at www.toxicology.org 91 , 1 , , 1 1 M. . . 2
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, T. Wade T. , 2 1, 4 U.S. EPA, EPA, U.S. 1 , K. Wu , K. . 2 5 , K. M. Crofton Environmental Environmental , R. Barbee 1 1 3 S. Naragoni . , A. Valcour A. , , Y. Xia Y. , 4 ORD/NHEERL, 1 Inner Mongolia Center ORD/NHEERL, 1, 2 1 2 2 M. Madden U.S. EPA, Research EPA, U.S. . . , Y. Xia Y. , 3 1 1 Molecular Biosciences, 2 University of North University 3 , EXPRESSION ERCC1, and Z. Yang and Z. 4 J. L. Rayner , J. 1 National Research Council, Inner Mongolia Center for 1 2 M. Madden Department of Chemistry, Southern Department of Chemistry, . 2 3 Reproductive Toxicology, U.S. EPA, EPA, U.S. Toxicology, Reproductive Zoology, North Carolina State Zoology, 4 W. G. Gray G. and W. , J. G. Vandenbergh G. , J. 1 , R. A. Moreland , R. 1 2 . 4 2, 4 , R. Kwok 3 and S. E. Fenton 2 E. P. Hines E. P. DESE, UNC-Chapel Hill, Chapel Hill, NC and 3 LabCorp, Inc., Burlington, NC. Neurotoxicology, U.S. EPA, Research Triangle Triangle Research EPA, U.S. Neurotoxicology, Washington, DC, Washington, DNA REPAIR GENE, GENE, REPAIR DNA and J. Mumford and J. Inner Mongolia, China, Carolina Medical School, Chapel Hill, NC, China. Sponsor: Inner Mongolia, China and Mumford MONGOLIA. J. E. Sanders for Endemic Disease Control and Research, Huhhot, NC and Park, Triangle International, Research J. Mo INNER MONGOLIA. J. Endemic Disease Control and Research, Huhhot, Howdeshell Heidenfelder Gallagher NC, 4 3 NC and Park, ENDOGENOUS COMPONENTS OF HUMAN MILK. and L. Gray SCREENING OF PUTATIVE SCREENING OF PUTATIVE RESPONSIVE GENES PHYTOESTROGEN ACTIVITY. FOR ESTROGEN R. Solipuram Rouge, LA and A & M, Baton Rouge, LA. University THE EFFECTS ASSESSMENT OF AN LACTATIONAL AND OF GESTATIONAL ETHINYL ESTRADIOL TO EXPOSURE ON A (BPA) AND BISPHENOL (EE) AND MORPHOLOGY REPRODUCTIVE MALE LONG AND IN FEMALE BEHAVIOR C. Ryan B. RAT. HOODED EVANS Triangle Park, NC. Sponsor: Park, Triangle AND PROLONGATION ECG QT INTERVAL IN INNER ARSENIC EXPOSURE CHRONIC North Carolina State University, Raleigh, NC, North Carolina State University, University, Raleigh, NC, University, Human Studies Division, U.S. EPA, Chapel Hill, EPA, U.S. Human Studies Division, Research Triangle Park, NC. Park, Triangle Research FOR DETERMINING ASSAYS RELIABLE Research Triangle Park, NC, Park, Triangle Research AND CHRONIC ARSENIC EXPOSURE IN ARSENIC AND CHRONIC Toxicology, Southern University A & M, Baton Southern University Toxicology, Men Anti-epidemic Station, Lin He, Inner Mongolia, Inner He, Lin Station, Anti-epidemic Men Reproductive Toxicology Division, U.S. EPA, EPA, U.S. Division, Toxicology Reproductive NC, Park, Triangle Research
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#407 Attended: Monday, March 6 March Monday, Exhibit Hall TOXICOLOGY ARSENIC POSTER SESSION: of Maryland, Baltimore, Chairperson(s): Katherine Squibb, University Sweden. Institutet, Stockholm, Karolinska MD and Monica Nordberg, Displayed: 1:30 PM to 4:30 PM #405 #404
#408 Program Description Description Program #406
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #417 P53 SUPPRESSION OF ARSENITE-INDUCED #425 ARSENITE AND MONOMETHYLARSONOUS MITOTIC CATASTROPHE IS MEDIATED ACID GENERATE OXIDATIVE STRESS BY P21WAF1/CIP1. B. F. Taylor1, S. C. McNeely1, H. L. RESPONSE IN HUMAN BLADDER CELL Miller1, M. J. McCabe2 and J. States1. 1Pharmacology CULTURE. K. E. Eblin1, D. Cromey2, M. E. & Toxicology, University of Louisville, Louisville, Bowen1, T. G. Bredfeldt1, E. A. Mash3 and A. KY and 2Environmental Medicine, University of J. Gandolfi1. 1Pharmacology and Toxicology, Rochester, Rochester, NY. University of AZ, Tucson, AZ, 2Cell Biology and Anatomy, University of AZ, Tucson, AZ and #418 ARSENIC: A POTENTIAL 3Chemistry, University of AZ, Tucson, AZ. CHEMOTHERAPEUTIC FOR MELANOMA. S. C. McNeely, B. F. Taylor and J. States. Pharmacology #426 EXPRESSION OF AS3MT ALTERS & Toxicology, University of Louisville, Louisville, TRANSCRIPTIONAL PROFILES IN HUMAN KY. UROTHELIAL CELLS EXPOSED TO ARSENITE. S. Hester1, Z. Drobna2, D. Ducharme3, #419 THE ROLE OF LXR/RXR HETERODIMERS M. Waalkes4, D. J. Thomas1 and M. Styblo2. IN ARSENIC-INDUCED ATHEROSCLEROSIS. 1Department of Nutrition, University of North K. K. Mann, A. S. Padovani, Q. Guo and W. H. Carolina, Chapel Hill, NC, 2U.S. EPA, Research Miller. Lady Davis Institute for Medical Research, Triangle Park, NC, 3NIEHS, Research Triangle Park, McGill University, Montréal, QC, Canada. NC and 4NCI at NIEHS, Research Triangle Park, #420 ARSENITE INDUCES S PHASE DELAY IN NC. U937 CELLS VIA DOWNREGULATION OF #427 ACUTE AND CHRONIC EXPOSURE OF CDC25A PHOSPHATASE. G. M. Lehmann and M. MONOMETHYLARSONOUS ACID TO J. McCabe. Department of Environmental Medicine, HUMAN BLADDER CELLS INDUCES University of Rochester, Rochester, NY. CYCLOOXYGENASE-2. A. J. Gandolfi1, T. G. 2 1 1 1 #421 CHRONIC LOW DOSE AS(III) TOGETHER Bredfeldt , S. E. Salt , X. H. Zheng , N. L. Lane , 3, 1 2 1 WITH CONTINUOUS HIGH GLUCOSE G. S. Watts and E. A. Mash . Pharmacology and RESULTS IN A ROS-MEDIATED Toxicology, University of Arizona, Tucson, AZ, 2 STIMULATION OF HYPERGLYCEMIC Chemistry, University of Arizona, Tucson, AZ and 3 STRESS MARKERS IN ISOLATED Arizona Cancer Center, University of Arizona, ENDOTHELIAL CELLS. M. A. Ihnat1, S. Shakir1, Tucson, AZ. 1 1 2 J. E. Thorpe , L. A. Warnke , A. Andrew and J. W. #428 EFFECT OF ARSENITE ON CELL CYCLE 2 1 Hamilton . Cell Biology, University Oklahoma PROGRESSION AND P53 FUNCTIONALITY MONDAY Health Sciences Center, Oklahoma City, OK and IN HUMAN BLADDER CELL LINE, HT1197. 2 Pharmacology/Toxicology, Dartmouth Medical A. Hernandez-Zavala1, 2, E. Cordova3, L. M. Del School, Hanover, NH. Razo1, M. E. Cebrián1 and E. Garrido1. 1Cinvestav, 2 #422 INTERACTION OF ARSENIC WITH WNT/ - Mexico D.F., Mexico, INSP, Cuernavaca, Mexico Β 3 CATENIN PATHWAYS IN HUMAN COLON and UNAM, Mexico D.F., Mexico. 1 CANCER CELLS LINES. R. C. Goytia Acevedo , #429 INTERACTIONS OF ARSENIC WITH HUMAN 2 2 1 E. R. Abril and R. Lantz . Facultad de Medicina, PROSTATE PROGENITOR CELLS. E. J. Tokar1, 2 Gómez Palacio, Durango, Mexico and Cell Biology W. Qu1, M. M. Webber2 and M. P. Waalkes1. 1LCC, and Anatomy, University of Arizona, Tucson, AZ. NCI at NIEHS, Research Triangle Park, NC and 2 #423 INITIATION AND PROGRESSION OF Michigan State University, East Lansing, MI. ATHEROSCLEROSIS IN APOE-/- /LDLR-/- #430 ALTERED S-ADENOSYLMETHIONINE MICE EXPOSED TO ARSENIC IN DRINKING METABOLISM AND GLUTATHIONE WATER. F. E. Pereira, M. C. Schneider, J. D. Coffin PRODUCTION IN THE EARLY STAGES and H. D. Beall. Biomedical and Pharmaceutical OF CHRONIC ARSENIC EXPOSURE IN Sciences and Center for Environmental Health HUMAN PROSTATE EPITHELIAL CELLS: Sciences, The University of Montana, Missoula, IMPLICATIONS IN ARSENIC ADAPTATION. Missoula, MT. J. Coppin1, L. Benbrahim-Tallaa1, M. M. Webber2 1 1 #424 MONOMETHYLARSONOUS ACID and M. P. Waalkes . LCC, NCI at NIEHS, Research 2 TRANSFORMS HUMAN BLADDER CELLS. Triangle Park, NC and Michigan State University, T. G. Bredfeldt1, X. H. Zheng1, G. S. Watts1, E. A. East Lansing, MI. 2 1 1 Mash and A. J. Gandolfi . Pharmacology and #431 UROGENITAL CARCINOGENESIS IN Toxicology, University of Arizona, Tucson, AZ and FEMALE CD1 MICE INDUCED BY IN UTERO 2 Chemistry, University of Arizona, Tucson, AZ. ARSENIC EXPOSURE IS ENHANCED BY POSTNATAL DIETHYLSTILBESTROL TREATMENT. M. P. Waalkes1, J. Liu1, J. M. Ward2, D. A. Powell3 and B. A. Diwan4. 1LCC, NCI at NIEHS, Research Triangle Park, NC, 2NIAID, Bethesda, MD, 3NCI at Frederick, Frederick, MD and 4SAIC at Frederick, NCI at Frederick, Frederick, MD. up-to-date information at www.toxicology.org 93 X. 1, , and , 1 M. , Z. 1 and D. J. J. , D. 2 1 U.S. EPA, EPA, U.S. 2 , L. R. Klei L. J. Bain and L. J. ETD, NHEERL, NHEERL, ETD, 1 J. F. Robinson F. J. Environmental Environmental 2 A. J. McNally A. J. CEMLB, Chapel CEMLB, 1 3 2, 1 . 1 Annual Meeting Annual th Nutrition, University Nutrition, University Z. Drobna 1 . D. J. Thomas J. , D. 1 Environmental Science and Environmental 1, 3 2 , D. B. Stolz B. , D. 1 Chemical Institute of Industrial H. Gonzalez 2 SOT's 45 SOT's and A. Barchowsky 2 Department of Nutrition, University of Department of Nutrition, University 1 and M. Styblo A. C. Straub . , A. W. Harmon W. A. , 2 1 1, 3 Biological Sciences, University of Texas at El Texas of Sciences, University Biological , S. Hong, E. Kim, J. S. Sidhu and , S. Hong, E. Kim, J. Gribble , E. J. 1 . CEMALB, University of North Chapel Carolina, University CEMALB, Paso, El Paso, TX and El Paso, Paso, N. V. Soucy V. N. and Occupational Health, University of Pittsburgh, of Pittsburgh, and Occupational Health, University and PA Pittsburgh, . Center for Environmental and Human and Human S. Barber. Center for Environmental D. of Florida, Gainesville, FL. University Toxicology, AS3MT SILENCING OF SHRNA-MEDIATED THE CAPACITY EXPRESSION MODULATES METHYLATE TO OF HEPG2 CELLS ARSENIC. INORGANIC Yu Thomas Hill, NC. ALTERS ARSENIC EXPOSURE PARENTAL THE OFFSPRING OF GENE EXPRESSION IN MUMMICHOGS. 2 TX. ARSENIC-INDUCED OF EXAMINATION IN CELL CYCLE ALTERATIONS GENE AND GLOBAL PROGRESSION TRANSGENIC MOUSE EXPRESSION IN P53 FIBROBLASTS. EMBRYONIC METABOLISM OF ARSENITE IN CULTURED IN CULTURED ARSENITE OF METABOLISM SIX FROM HEPATOCYTES PRIMARY Walton S. F. MAMMALIAN SPECIES. Drobna 3 Hill, NC. PRO-ANGIOGENIC ARSENIC STIMULATES IN AND CHANGES GENE EXPRESSION THE IN ARCHITECTURE VASCULAR LIVER. Engineering, University of Texas at El Paso, El Paso, El Paso, at El Paso, Texas of Engineering, University Styblo North Carolina, Chapel Hill, NC, of North Carolina, Chapel Hill, NC, U.S. EPA, Research Triangle Park, NC and Park, Triangle Research EPA, U.S. Research Triangle Park, NC and Park, Triangle Research . Environmental and Occupational . Environmental E. M. Faustman Seattle, Washington, of Health Sciences, University WA. Toxicology, Research Triangle Park, NC. Park, Triangle Research Toxicology, ALTERNATIVELY AN OF IDENTIFICATION THE HUMAN CYT19 SPLICED ISOFORM OF AN S-ADENOSYL-L-METHIONINE: GENE, AS-METHYLTRANSFERASE.
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Arizona Respiratory P. Lin and P. 1 3 . , J. Nakamura , J. S. Boitano 3 1 . , S. Bredow 1 R. Lantz , T. Cheng T. , 2 Lung Cancer Program, Lovelace Lovelace Lung Cancer Program, 1 . 1 and V. E. Walker E. , V. 1 1 Environmental Sciences and Engineering, Environmental National Taiwan University, Taipei, Taiwan, Taiwan, Taipei, University, Taiwan National 2 , H. Yu , H. 2 1 . Chung Shan Medical University, Taichung, Taichung, Chung Shan Medical University, 4 Kaohsoung Medical University, Kaohsiung, Taiwan Taiwan Kaohsiung, Kaohsoung Medical University, AZ and Tucson, Arizona, of University Physiology, Arizona, of University Anatomy, and Cell Biology Respiratory Research Institute, Albuquerque, NM, Albuquerque, Respiratory Research Institute, A. Belinsky Walker CENTROSOME ABNORMALITY AND ABNORMALITY CENTROSOME (CELL CELL COLONY FORMATION LUNG IN HUMAN TRANSFORMATION) ARSENIC. CELLS INDUCED BY , B. Nemeti and I. Csanaky. Department of Nemeti and I. Csanaky. , B. Gregus of University and Pharmacotherapy, Pharmacology Hungary. Pecs, Pecs, NM and 2 3 CELLS. K. Divine and EPITHELIAL CELLS. A. Liguori AZ. Tucson, LEVEL LOW EFFECTS OF CHRONIC ARSENIC EXPOSURE ON IMMORTALIZED EPITHELIAL HUMAN LUNG BRONCHIAL 3 M. Walker M. . Pharmacology and Toxicology, University of University Toxicology, and Rice. Pharmacology CA. Davis, California - Davis, AND IRRADIATION ULTRAVIOLET ARSENITE INDUCE MITOGEN-ACTIVATED TARGET AND SIGNALING KINASE PROTEIN ALTERATIONS. PROTEIN GENE EXPRESSION IN NORMAL HUMAN GENE EXPRESSION BY MODULATED KERATINOCYTES R. D. A. Bailey, K. ARSENICALS. TRIVALENT Park, Triangle Research Thai. EPA, and S. Owen Wolf NC. Sponsor: D. Center, University of Arizona, Tucson, AZ, Tucson, Arizona, of University Center, L. G. Hudson. College of Pharmacy, UNMHSC, of Pharmacy, L. G. Hudson. College NM. Albuquerque, INCREASES ARSENITE SYNERGISTICALLY IN DAMAGE DNA OXIDATIVE UV-INDUCED INHIBITING BY HUMAN KERATINOCYTE Ding, L. G. W. OF PARP-1. ACTIVITY THE University Pharmacy, of College Liu. K. and Hudson NM. Sponsor: Albuquerque, Mexico, of New Taiwan. ARSENIC ENVIRONMENTAL CALCIUM ALTER CONCENTRATIONS IN LUNG REPAIR WOUND AND SIGNALING DIVERGENT EFFECTS OF VARIOUS VARIOUS OF DIVERGENT EFFECTS KERATINOCYTE ON HUMAN METALS and Reznikova V. T. HOMEOSTASIS. Environmental Health & Occupational Medicine, Health & Occupational Environmental National Health Research Institute, Miaoli County, Taiwan, University of NorthNC. Carolina, Chapel Hill, University OF AN INACTIVATOR EFFECT OF GLYCERALDEHYDE-3-PHOSPHATE A (GAPDH), DEHYDROGENASE ON REDUCTASE, ARSENATE FORTUITOUS IN RATS. ARSENATE DISPOSITION OF W. Liao W. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Monday, March 6 #452 MECHANISM OF INCREASED CELL 1:30 PM to 4:30 PM DIVISION AND PROTECTION OF MICE Exhibit Hall AGAINST S-1, 2-DICHLOROVINYL-L- CYSTEINE-INDUCED ACUTE RENAL 1 POSTER SESSION: KIDNEY FAILURE AND DEATH. M. C. korrapati , J. Chilakapati1, E. A. Lock2, J. R. Latendresse3, A. Chairperson(s): Brian Cummings, University of Georgia, Athens, GA and Warbritton3 and H. M. Mehendale1. 1Toxicology, Sue Ford, Saint Johns University, Jamaica, NY. ULM, Monroe, LA, 2BMS, LJMU, Liverpool, United Kingdom and 3NCTR, Jefferson, AR. Displayed: 1:30 PM–4:30 PM #453 EVALUATION OF OXIDATIVE DAMAGE AND Attended: 1:30 PM–3:00 PM RENAL DISTAL TUBULAR ANTIOXIDANT ENZYME RESPONSE FOLLOWING #446 EVALUATION OF THE 5/6 EXPOSURE TO LINDANE. A. L. Piskac and M. NEPHRECTOMIZED RAT MODEL OF A. Smith. Environmental Science, University of RENAL FAILURE AS A MODEL OF Texas-Houston School of Public Health, Houston, SECONDARY HYPERPARATHYROIDISM. TX. M. Boyer, D. Farrell, F. Vlasseros, E. Jacquinet, J. Jolette, C. Banks and S. Y. Smith. Toxicology, #454 COMPARISON OF ZUCKER OBESE AND Charles River Laboratories Preclinical Montréal, LEAN RATS SUSCEPTIBILITY TO RENAL Senneville, QC, Canada. TOXICANTS IN VITRO. M. Valentovic, W. McCumbee and R. G. Morrison. Pharmacology, #447 EXPRESSION PROFILES INDUCED BY Marshall University School of Medicine, RENAL CARCINOGENS IN EKER RATS Huntington, WV. COMPARED TO WILDTYP RATS. K. Stemmer1, H. Ellinger2, T. Lampertsdoerfer1, K. Lotz2, H. Ahr2 #455 PROTEIN BINDING OF 2’-METHOXYETHYL and D. R. Dietrich1. 1Environmental and Human (MOE) ANTISENSE OLIGONUCLEOTIDES Toxicology, University of Konstanz, Konstanz, (ASO) AND RENAL ACCUMULATION. T. A. Germany and 2Molecular and Genetic Toxicology, Watanabe, G. Riley, R. S. Geary and A. A. Levin. Bayer Healthcare AG, Wuppertal, Germany. ISIS Pharmaceuticals, Inc., Carlsbad, CA. #448 COMPARATIVE EARLY MOLECULAR #456 UPTAKE AND EFFECTS OF ANTISENSE RESPONSES TO CISPLATIN IN HUMAN AND OLIGONUCLEOTIDES ISIS 141923 AND RAT KIDNEY TUBULE CELLS IN VITRO. 107772 IN RENAL PROXIMAL TUBULAR MONDAY B. A. Fowler1, J. K. Babus2, M. M. Lipsky3 and J. CELLS. G. R. Kinsey1, S. P. Henry2 and R. G. A. Flaws2. 1ATSDR, Atlanta, GA, 2Epidemiology Schnellmann1. 1Pharmaceutical Sciences, Medical and Preventive Medicine, University of Maryland, University of South Carolina, Charleston, SC and Baltimore, MD and 3Pathology, University of 2ISIS Pharmaceuticals, Carlsbad, CA. Maryland, Baltimore, MD. #457 IDENTIFICATION OF RENAL PAPILLARY #449 A NOVEL METHOD FOR THE IN SITU NECROSIS USING AN EIA FOR URINARY EVALUATION OF PROXIMAL TUBULAR RENAL PAPILLARY ANTIGEN-1 (RPA-1): EPITHELIAL CELL viaBILITY USING A BIOMARKER OF COLLECTING DUCT ETHIDIUM HOMODIMER. E. Diamantakos, PATHOLOGY. A. Roche1, G. Elliott1, C. Kilty1, J. Edwards, J. D. Peuler, A. R. Carnes, P. C. Lamar M. Shaw1 and F. Falkenberg2. 1Biotrin International, and W. C. Prozialeck. Pharmacology, Midwestern Dublin, Ireland and 2CIRES GmbH, Dortmund, University, Downers Grove, IL. Germany. Sponsor: J. McKim III. #450 TOXICOPROTEOMICS STUDY ON 3-MCPD- #458 PATHOPHYSIOLOGICAL STUDIES ON INDUCED NEPHROTOXICITY IN RATS. CANINE RENAL PAPILLARY NECROSIS Y. Yum, S. Kim, D. Jang, S. Kim, M. Hwang and INDUCED BY NEFIRACEATM. Y. Tsuchiya1, D. Cho. Department of Toxicological Research, Y. Tominaga2, S. Takada1, K. Yabe1, T. Jindo1, National Institute of Toxicological Research, Seoul, K. Furuhama1 and K. T. Suzuki3. 1Drug Safety South Korea. Sponsor: J. Chung. Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan, 2Research Technology Center, #451 COMPARISON OF RESPONSE TO CISPLATIN Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan TREATMENT IN RAT AND PRIMATE and 3Department of Toxicology and Environmental PRECISION CUT RENAL CORTICAL SLICE Health, Graduate School of Pharmaceutical CULTURES. A. G. Aslamkhan. Safety Assessment, Sciences, Chiba University, Chiba, Japan. Merck & Co., Inc., West Point, PA. Sponsor: N. Bhandari. #459 DIETARY EFFECTS ON CELL PROLIFERATION AND APOPTOSIS IN P-NONYLPHENOL (NP) INDUCED POLYCYSTIC KIDNEY DISEASE (PKD) IN MALE SPRAGUE-DAWLEY RATS. S. M. Cooper1, X. Fu1, L. Muskhelishvili2, J. R. Latendresse2 and K. B. Delclos1. 1National Center for Toxicological Research, Jefferson, AR and 2Toxicologic Pathology Associates, Jefferson, AR. up-to-date information at www.toxicology.org 95
, 3 , 1 1 , 3 , 3 , H. 1 , L. 1 D. and D. IPMC- 2 3 , P. Wolf , P. V. S. V. 1 University of University University of University 4 4 Biochemistry , E. O’Brien 2 , A. H. , 1 and J. V. V. and J. , S. K. Rumpf 4 , M. Runkel 2 4 3 APOGEPHA, Environmental Environmental Environmental Environmental S. Huljic 4 1 1
TANDEM TANDEM VIA . . . 1 1 , B. Bruene , B. 1 Annual Meeting Annual -INDEPENDENT , E. O’Brien 1 2+ th , B. D. Humphreys D. , B. 2 , M. Runkel IN RENAL CELL IN RENAL 4 2 , T. Gramatte T. , , M. A. Moses , M. 1 3 Environmental Toxicology, Toxicology, Environmental 1 . , E. OBrien 1 Center for Matrix Biology, Beth Center for Matrix Biology, 2 3 SOT's 45 SOT's Environmental Toxicology, University University Toxicology, Environmental D. R. Dietrich and D. D. R. Dietrich and D. 1 Medicine-Renal, Brigham and Women’s Women’s and Brigham Medicine-Renal, 2 2 1 . WESTERN BLOT AND BLOT WESTERN VIA , A. H. Heussner , 1 IPMC-TMC, Neuwilen, Switzerland, IPMC-TMC, Neuwilen, Switzerland, IPMC-TMC, Neuwilen, Switzerland, IPMC-TMC, Neuwilen, Switzerland, . , T. Gramatte T. , 3 , R. Kalluri 2 2 1 2 , E. O’Brien 3 1 , R. Koehl , C. A. Fernandez , C. 2 1 APOGEPHA, Dresden, Germany and and APOGEPHA, Dresden, Germany University of Pittsburgh, Pittsburgh, PA, PA, Pittsburgh, of Pittsburgh, University and APOGEPHA, Dresden, Germany Vascular Biology Program, Children’s Hospital, Children’s Program, Biology Vascular PHOSPHOLIPASE A PHOSPHOLIPASE University of Konstanz, Konstanz, Germany, Germany, Konstanz, of Konstanz, University PA. Pittsburgh, Pittsburgh, PROTEIN PROPIVERINE-INDUCED SITE- IN F344 RATS. ACCUMULATION AND SUBSEQUENT SPECIFIC EXCISION IDENTITY CONFIRMATION PA. Pittsburgh, Pittsburgh, Hospital, Harvard Medical School, Boston, MA, Hospital, Harvard MASS SPECTROMETRY OF D-AMINO MASS SPECTROMETRY IN RENAL ACCUMULATED OXIDASE ACID Day W. B. TUBULES. PROXIMAL R. Dietrich M. Runkel Heussner S. K. Rumpf 3 IN VITRO THE CELL CYCLE IN Helbig R. Dietrich and D. 2 TMC, Neuwilen, Switzerland and S. K. Rumpf 3 Sugimoto 2 Boston, MA and GA. THE NEPHROTOXIC EFFECT OF (AA), ACID ARISTOLOCHIC COMPOUNDS ACETATE METHYAZOXYMETHANOL ON A (OTA) AND OCHRATOXIN (MAMAC) Gramatte T. IMMUNOHISTOCHEMISTRY. POTENTIAL ROLE OF KIDNEY INJURY INJURY OF KIDNEY ROLE POTENTIAL CELL MOLECULE-1 IN ENDOTHELIAL ANGIOGENESIS. AND MIGRATION Toxicology, University of Konstanz, Konstanz, Konstanz, of Konstanz, University Toxicology, Germany, I - Pathobiochemistry, University of Frankfurt, University I - Pathobiochemistry, Frankfurt, Germany. PROTEIN PROPIVERINE-INDUCED PROTEIN RATS: IN F344 ACCUMULATION A. H. Heussner IDENTIFICATION. Konstanz, of Konstanz, University Toxicology, Germany, Vaidya Bonventre Dresden, Germany. PROTEIN PROPIVERINE-INDUCED RATS. IN F344 ACCUMULATION OF DOSE-DEPENDENCY DEMONSTRATION LOCALIZATION AND INTRARENAL ACID D-AMINO ACCUMULATED OF OXIDASE of Konstanz, Konstanz, Germany and Germany Konstanz, of Konstanz, Israel Deaconess Medical Center, Boston, MA. Center, Israel Deaconess Medical FOR CA ROLES NOVEL G. Saavedra, AND PROLIFERATION. GROWTH and Cummings S. . Pharmacology and B. Zhang W. Athens, of Georgia, Biomed. Sciences, University B. W. Day W. B.
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-(1, S-(1, , 2 E. A. , E. 1 Battelle 3 G. C. , G. 1 C. R. Kirman K. McMartin H. Z. Qui and , Biomolecular 3 , R. Paules 2 1 S. P. Sawant , S. P. H. M. Mehendale Toxicology and Safety Toxicology 1 1 . 1 The Sapphire Group, and 4 3 , B. Knight , B. Dow Chemical, Midland, Chemical, Midland, Dow W. M. Snellings , W. 2 1 1 R. A. Corley , R. 1 . 1 A. V. Dnyanmote V. A. and S. Jayadev T. Auman , T. 1 , D. Orlicky, N. Lassen, T. Estey, Estey, T. Lassen, N. Orlicky, , D. Vasiliou V. 1 , D. Anestis, L. Waugh and S. Waugh Anestis, L. Rankin, D. O. G. D. M. Wilson M. D. , M. J. Bartels , M. J. J. R. Latendresse , J. 2 Pathologist, Tairua, New Zealand, Zealand, New Tairua, Pathologist, NIEHS, Research Triangle Park, NC. Park, Triangle NIEHS, Research 2 2 2 Toxicology, ULM, Monroe, LA, Toxicology, AR. NCTR, Jefferson, Pathology, Toxicologic Sciences, LJMU, Liverpool, United Kingdom and Liverpool, Sciences, LJMU, Lock NW, Richland, WA and WA Richland, NW, 2-DICHLOROVINYL)-L-CYSTEINE (DCVC)- 2-DICHLOROVINYL)-L-CYSTEINE IN AND NECROSIS APOPTOSIS INDUCED CELLS. TUBULAR HUMAN PROXIMAL Pharmacology, Toxicology & Neuroscience, LSU Toxicology Pharmacology, LA. Shreveport, Health Sciences Center, BY LLC-PK1 ACYCLOVIR OF TRANSPORT ON FILTERS. CELLS GROWN Brown. Pharmacology, Physiology & Toxicology, Toxicology, & Physiology Pharmacology, Brown. WV. Huntington, Marshall University, IS OSTEOPONTIN UPREGULATION WITH ENHANCED COMMENSURATE OF AND PROTECTION TISSUE REPAIR RENAL ACUTE AGAINST DIABETIC KIDNEY INDUCED AND DEATH (ARF) FAILURE BY DCVC. 1 3 7A1 DEHYDROGENASE ALDEHYDE HUMAN OSMOTIC AGAINST (ALDH7A1) PROTECTS STRESS. CELLS. MI, Garcia and CELLS. C. Guo, M. D. and and K. E. Stebbins D. Arrington Schnellmann and R. G. (ORP150). D. Assessment, Boehringer Ingelheim, Ridgefield, CT MITOCHONDRIAL DYSFUNCTION IN DYSFUNCTION MITOCHONDRIAL Xu. A. Putt and F. D. L. H. Lash, I. Papanayotou, Sch. Med., State University Wayne Pharmacology, Detroit, MI. OF LOCALIZATION MITOCHONDRIAL 150 PROTEIN OXYGEN-REGULATED A. Pappa, M. Gu and R. Agarwal. Pharmaceutical Agarwal. M. Gu and R. A. Pappa, CO. Sciences, UCHSC, Denver, Q. Huang Q. . Toxicology Program, St. John’s University, University, St. John’s Program, Toxicology . M. Ford Jamaica, NY. INDUCED NEPHROTOXICITY DICLOFENAC CORTICAL RENAL ISOLATED IN RAT Pharmaceutical Charleston, SC. Sciences, MUSC, THE NEPHROTOXICITY OF COMPARISON IN RATS DRUGS OF IMMUNOSUPPRESSIVE ANALYSES. USING GENE EXPRESSION Blanchard 12-MONTH DIETARY ETHYLENE GLYCOL ETHYLENE GLYCOL 12-MONTH DIETARY AND CLEARANCE TOXICITY, RENAL WISTAR IN MALE STUDY METABOLISM RATS. Hard OH. Beachwood, TOXICITY BLOCKS ALUMINUM CITRATE BY INHIBITING CRYSTALS OF OXALATE TUBULE PROXIMAL TO THEIR BINDING 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #475 PROPIVERINE-INDUCED PROTEIN #480 GLUCURONIDATION AS A METABOLIC ACCUMULATION IN F344 RATS. PATHWAY TERMINATING REDOX CHARACTERIZATION OF RENAL α2U- CYCLING OF 9, 10-PHENANTHRAQUINONE GLOBULIN INDUCTION. D. R. Dietrich1, A. H. ASSOCIATED WITH OXIDATIVE STRESS. Heussner1, E. O’Brien1, T. Gramatte3, M. Runkel3 K. Taguchi and Y. Kumagai. Doctoral Program and S. K. Rumpf2. 1Environmental Toxicology, in Social and Environmental Medicine, Graduate University of Konstanz, Konstanz, Germany, 2IPMC- School of Comprehensive Human Sciences, TMC, Neuwilen, Switzerland, 3APOGEPHA, University of Tsukuba, Tsukuba, Japan. Sponsor: A. Dresden, Germany and 4University of Pittsburgh, Naganuma. Pittsburgh, PA. #481 HYPOXIA-INDUCED OXIDATIVE STRESS #476 PROPIVERINE-INDUCED PROTEIN RESPONSES IN MACROPHAGES AND ACCUMULATION IN F344 RATS. EPITHELIAL CELLS. A. Connor, N. Pierre, J. D. REVERSIBILITY OF PATHOLOGICAL Laskin, J. P. Gray and D. L. Laskin. Joint Graduate CHANGES AND PROTEIN ACCUMULATION. Program in Toxicology, Rutgers University and M. Runkel3, S. K. Rumpf2, A. H. Heussner1, UMDNJ-Robert Wood Johnson Medical School, E. O’Brien1, T. Gramatte3 and D. R. Dietrich1. Piscataway, NJ. 1Environmental Toxicology, University of Konstanz, Konstanz, Germany, 2IPMC-TMC, Neuwilen, #482 THE OXIDATIVE EFFECTS OF CIGARETTE Switzerland and 3APOGEPHA, Dresden, Germany. SMOKE ELECTROPHILIC CONSTITUENTS ON THE MEMBRANE OF A HUMAN LUNG #477 PROPIVERINE-INDUCED PROTEIN EPITHELIAL CELL LINE. M. R. Robles1 and J. ACCUMULATION IN F344 RATS. Avalos2. 1Soka University of America, Aliso Viejo, ASSESSMENT OF CELL PROLIFERATION, CA and 2TopTox Consulting, Sacramento, CA. CONCLUSIONS AND HUMAN RISK ASSESSMENT. E. O’Brien1, M. Runkel3, S. K. #483 CHEMICAL DEPENDENT Rumpf2, A. H. Heussner1, T. Gramatte3, B. W. Day4 PHOSPHORYLATION OF HEAT SHOCK 1 1 2 and D. R. Dietrich1. 1Environmental Toxicology, PROTEIN 27. J. L. Lord , Z. Jia , M. D. Person , J. 3 1 1 1 University of Konstanz, Konstanz, Germany, 2IPMC- Shen , T. J. Monks and S. S. Lau . Department of TMC, Neuwilen, Switzerland, 3APOGEPHA, Pharmacology & Toxicology, College of Pharmacy, 2 Dresden, Germany and 4University of Pittsburgh, University of Arizona, Tucson, AZ, Division of Pittsburgh, PA. Pharmacology & Toxicology, College of Pharmacy, University of Texas, Austin, Austin, TX and
3UTMDACC, Science Park - Research Division, MONDAY Monday, March 6 Smithville, TX. 1:30 PM to 4:30 PM Exhibit Hall #484 HYPERGLYCEMIA DECREASES MITOCHONDRIAL FUNCTION: THE POSTER SESSION: OXIDATIVE INJURY MECHANISMS REGULATORY ROLE OF MITOCHONDRIAL BIOGENESIS. C. M. Palmeira1, A. P. Rolo1, J. Chairperson(s): Joan Tarloff, University of the Sciences, Philadelphia, PA Berthiaume2, J. A. Bjork2 and K. B. Wallace2. 1Center and Louis Trombetta, Saint Johns University, Jamaica, NY. for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal Displayed: 1:30 PM–4:30 PM and 2Department of Biochemistry & Molecular Biology, University of Minnesota Medical School, Attended: 3:00 PM–4:30 PM Duluth, MN. #478 INDICES OF ANTIOXIDANT STATUS IN SHEEP AFTER EXPOSURE TO CHLORINE #485 CORRELATION OF REACTIVE OXYGEN GAS. M. A. Dubick, D. G. Cameron, A. I. SPECIES AND MENADIONE- OR PARA- Batchinsky and L. C. Cancio. U.S. Army Institute AMINOPHENOL-INDUCED CYTOTOXICITY. of Surgical Research, San Antonio, TX. Sponsor: S. B. D. Foreman and J. B. Tarloff. Pharmaceutical Omaye. Sciences, University of the Sciences in Philadelphia, Philadelphia, PA. #479 INDUCTION OF OXIDATIVE LUNG INJURY AND CELLULAR RESPONSES BY DIESEL #486 NITROXYL (HNO) INHIBITS CATALASE EXHAUST PARTICLES IN WILD TYPE AND AND GLUTATHIONE PEROXIDASE, INDUCIBLE NITRIC OXIDE SYNTHASE- BOTH PURIFIED AND IN MACROPHAGE DEFICIENT MICE. J. Y. Ma1, M. Barger1, J. CELLS, SLOWING THE CATABOLISM OF K. Ma2 and V. Castranova1. 1HELD, NIOSH, HYDROGEN PEROXIDE. M. I. Jackson and J. Morgantown, WV and 2School of Pharmacy, WVU, M. Fukuto. Molecular Toxicology, University of Morgantown, WV. California, Los Angeles, Los Angeles, CA. Sponsor: R. Schiestl. #487 INSTABILITY OF LACTATE DEHYDROGENASE ACTIVITY IN THE PRESENCE OF CHEMICALS. D. M. Kendig and J. B. Tarloff. Pharmaceutical Sciences, University of the Sciences in Philadelphia, Philadelphia, PA. up-to-date information at www.toxicology.org 97 , 2 M. , , M. 1 . 2
and D. and D. 2 1 , S. B. and B. T. R. and T. 1 and T. J. J. T. and 1 Preventative Preventative , W. Dettbarn W. , 2 1 - 2+ H. G. Shertzer , H. G. Annual Meeting Annual B. Peterson B. th , D. S. DeWitt S. , D. 2 D. Milatovic and D. D. Milatovic D. T. W. Kensler W. , T. 2 M. Aschner , M. 1 R. C. Gupta
Y. Chen Y. SOT's 45 SOT's Anesthesiology, University of Texas Texas of University Anesthesiology, T. P. Dalton. Department of P. and T. N. C. Burton N. , S. Milatovic 1 2 Vanderbilt University, Nashville, TN and Nashville, University, Vanderbilt , V. Ramanujam V. , . 1 1 , R. M. Breyer 1 1 . Vanderbilt University, Nashville, TN. Nashville, University, Vanderbilt 2 2 KNOCKOUT MICE Gclm(-/-) KNOCKOUT . University of Washington, Seattle, WA. Seattle, Washington, of University Toxicology, Murray State University, Hopkinsville, State University, Murray Toxicology, SILYMARIN PRE-EXPOSURE MODULATES PRE-EXPOSURE MODULATES SILYMARIN AND BCL-XL STRESS OXIDATIVE AND THE LIVER EXPRESSION IN PREVENTS DOXORUBICIN-INDUCED CELL AND NECROTIC APOPTOTIC Toxicology Ray. Mol. S. D. and Patel N. DEATHS. of Pharma. Scs., Long Island Division Prog., NY. Brooklyn, University, IN ALTERATIONS AGE-RELATED NEURONAL INFLAMMATION-INDUCED DAMAGE. OXIDATIVE Medical Branch, Galveston, TX and Medical Branch, Galveston, IDENTIFICATION OF PHOSPHOLIPIDS OF PHOSPHOLIPIDS IDENTIFICATION BY SPECIFIC CA TARGETED D. W. Nebert W. D. . Environmental Health Sciences, Johns Guilarte. Environmental Health, School of Public Hopkins Bloomberg Baltimore, MD. Montine 2 Biomed Sciences, S. Cummings. Pharmacology Athens, GA. of Georgia, University INDUCED TISSUE-SPECIFIC DYSFUNCTION VESSELS: IN BLOOD BY MENADIONE of-SHAPE MECHANISMS FOR Universtiy Han, K. Bae, J. O. DOSE-RESPONSE CURVE. of Pharmacy, Chung. College Lim, S. Chung and J. Seoul, South Korea. Seoul National University, DERIVED FIBROBLASTS MOUSE FETAL FROM RELEASE OF ZINC BY REACTIVE OXYGEN OXYGEN REACTIVE RELEASE OF ZINC BY BRAIN INJURY TRAUMATIC AND SPECIES MEASURED USING HIPPOCAMPAL AND GRAPHITE MICRODIALYSIS ABSORPTION ATOMIC FURNACE E. Hawkins B. SPECTROPHOTOMETRY. S. Prough Moslen OF BY MEMANTINE PROTECTION OXIDATIVE CARBOFURAN-INDUCED IN BRAIN. DAMAGE 1 KY and Environmental Health, University of Cincinnati Health, University Environmental Cincinnati, OH. Medical Center, THE OF ATTENUATION VIVO IN BY PHENOTYPE PARKINSONIAN THE KEAP1-NRF2 INDUCTION OF PATHWAY. A. Parsley SENESCENCE UNDERGO PREMATURE IN CELL CULTURE. ISOFORMS DURING OXIDANT-INDUCED ISOFORMS DURING OXIDANT-INDUCED NEURAL CELL DEATH. Medicine & Community Health, University of Health, University Medicine & Community TX. Sponsor: Medical Branch, Galveston, Texas INDEPENDENT PHOSPHOLIPASE A INDEPENDENT PHOSPHOLIPASE M. Aschner M. Milatovic
(Continued) Annual Annual th #497 #498 #499 #500 #501 #495 #496 #502 45 98 Meeting & ToxExpo & Meeting . 1 and A. D. , D. 1 . . E. A. Hassoun E. D. Petersen and D. 1 , D. Morin, B. Morin, B. Spiess, D. P. , Z. Kiebler 3 H. Fujimura, I. Nakamura, E. T. J. J. and T. L. McConnachie, I. Mohar . J. Doorn , J. 2 Pharmaceutical Sciences, University of Pharmaceutical Sciences, University Health Sciences, and Radiological Environmental of Medicinal and Natural Products, University MEASURING OXIDATIVE STRESS AND DNA AND DNA STRESS MEASURING OXIDATIVE IN CELLS USING HIGH CONTENT DAMAGE Barchowsky Dekura, Y. Ishizuka, C. Aruga and W. Toriumi. Toriumi. W. Aruga and Ishizuka, C. Y. Dekura, & DMPK Research Toxicology Exploratory Toda, Seiyaku Co., Ltd., Tanabe Laboratories, S. Dey. Pharmacology, University of Toledo, Toledo, Toledo, Toledo, of University Pharmacology, S. Dey. CHARACTERIZATION OF THE EFFECTS OF CHARACTERIZATION ALDEHYDE MODIFICATION OF LIPID Roede 6. J. OF PEROXIREDOXIN Colorado Health Sciences Center, Denver, CO., CO., Denver, Colorado Health Sciences Center, Collins, CO and Fort Colorado State University, 3 IA. City, Iowa Iowa, Carbone 1 2 T. Inoue Saitama, Japan. Sponsor: T. R. Haskins. and J. Vasudevan SCREENING. C. Sponsor: PA. Cellomics, Inc., Pittsburgh, OH. A-INDUCED OXIDATIVE CYCLOSPORINE STRESS DETECTED BY FLUORESCENCE AND DIFFERENTIAL GENE PROBES PRIMARY EXPRESSIONS IN RAT HEPATOCYTES. . Department of Molecular Boland and A. Buckpitt of Med., University Vet. Biosciences, School of CA. Davis, California - Davis, AND DICHLOROACETATE- TRICHLOROACETATE-INDUCED AND ACTIVATION PHAGOCYTIC THE IN STRESS INDUCTION OF OXIDATIVE TISSUES OF MICE. HEPATIC C. C. Franklin and C. and C. C. Franklin MAMMALIAN CELLS. Department of Pharmaceutical Sciences, Brocker. Colorado Health Sciences Center, of University Kavanagh Sponsor: T. CO. Denver, GENDER DIFFERENCES IN GENDER DIFFERENCES ACETAMINOPHEN-INDUCED AND GCLM- WILD-TYPE IN HEPATOXICITY NULL MICE. and Occupational Health . Environmental Kavanagh WA. Seattle, Washington., of Sciences, University TRANSDUCTION PROTEIN TAT-MEDIATED CYSTEINE LIGASE INTO OF GLUTAMATE FLUORESCENT METHODS MULTIPLEXED FOR MEASURING PROTEIN/NONPROTEIN TO APPLICATION THE LUNG: THIOLS IN AROMATIC OF CYTOTOXIC THE STUDY HYDROCARBONS. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #503 IRON OVERLOAD DAMAGES #511 AUTOMATED ANALYSIS OF OXIDATIVE MITOCHONDRIAL DNA AND INHIBITS INJURY IN AN ANIMAL MODEL OF RESPIRATION IN VIVO AND IN VITRO. X. PARKINSON’S DISEASE. M. E. Cuda1, J. Callio2, Gao, M. Qian, J. Campian and J. Eaton. Brown C. Chu2, L. Reuter1, O. Lapets1 and J. R. Haskins1. Cancer center, University of Louisville, Louisville, 1Cellomics, Inc., Pittsburgh, PA and 2Department KY. of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA. Sponsor: A. Barchowsky. #504 Gclm(-/-) GENE-TARGETED MICE ARE RESISTANT TO OZONE-INDUCED ACUTE #512 WITHDRAWN LUNG INJURY. E. Johansson, Y. Chen, S. C. Wesselkamper, G. D. Leikauf and T. P. Dalton. #513 METAL OXIDE NANOPARTICLES PRODUCE Department of Environmental Health, University of OXIDATIVE STRESS IN CNS MICROGLIA 1 2 2 Cincinnati Medical Center, Cincinnati, OH. AND NEURONS. T. Long , N. Saleh , T. Phenrat , C. Swartz1, J. Parker3, G. V. Lowry2 and B. Veronesi4. #505 TRANSFECTION WITH HUMAN GSTA4-4 1Department of Environmental Sciences and ENHANCES RESISTANCE TO OXIDATIVE Engineering, UNC, Chapel Hill, NC, 2Civil and STRESS AND ACTIVATION OF GROWTH Environmental Engineering, CMU, Pittsburgh, FACTORS IN VASCULAR SMOOTH MUSCLE PA, 3Bioinformatics, Constella Health Sciences, CELLS VIA BAD PATHWAY. S. Dwivedi1, Y. Research Triangle Park, NC and 4NHEERL, NTD, Yang1, Y. C. Awasthi2 and P. J. Boor1. 1Pathology, U.S. EPA, Research Triangle Park, NC. University of Texas Medical Branch, Galveston, TX and 2Human Biological Chemistry and Genetics, Monday, March 6 University of Texas Medical Branch, Galveston, TX. 1:30 PM to 4:30 PM #506 HEPATIC OXIDATIVE STRESS RESPONSE Exhibit Hall TO CCL4. T. Sicilia1, R. Alvarez Sanchez2, R. Haas2, A. Goetschi2, F. Boess2, A. Mally1, A. POSTER SESSION: GENOTOXICITY/DNA REPAIR Paehler2, W. Dekant1 and W. Voelkel1. 1toxicology, university of wuerzburg, Wüerzburg, Germany Chairperson(s): J. Christopher States, University of Louisville, Louisville, and 2Pharmaceuticals, F. Hoffmann-La Roche Ltd., KY. Basel, Switzerland. Displayed: 1:30 PM–4:30 PM #507 A MODEL SYSTEM TO ASSESS THE Attended: 1:30 PM–3:00 PM
ROLE OF MODULATED GLUTAMATE- MONDAY CYSTEINE LIGASE IN TOXICANT #514 MLH1-DEPENDENT RESPONSES TO 2- INDUCED OXIDATIVE STRESS. D. Botta, AMINO-1-METHYL-6-PHENYLIMIDAZO L. A. McConnachie, C. Fernandez, P. A. Vliet, [4, 5-B] PYRIDINE (PHIP), A FOOD-BORNE C. C. White and T. J. Kavanagh. Environmental CARCINOGEN. S. L. Smith-Roe and A. B. and Occupational Health Sciences, University of Buermeyer. Environmental and Molecular Washington, Seattle, WA. Toxicology, Oregon State University, Corvallis, OR. #508 PROSTAGLANDINS STIMULATE GSH #515 MUTAGENIC AND CARCINOGENIC EFFLUX IN HUMAN EPITHELIAL CELLS. POTENTIAL OF MENADIONE. C. Cojocel1, B. J. Day1, 2, 3, C. T. Kariya1 and E. Min3. 1Molecular L. Novotny2 and A. Vachalkova3. 1Pharmacology Toxicology, UCHSC, Denver, CO., 2Medicine & and Toxicology, Kuwait University, Safat, Kuwait, Immunology, UCHSC, Denver, CO and 3Medicine & 2Pharmaceutical Chemistry, Kuwait University, Immunology, NJMRC, Denver, CO. Safat, Kuwait and 3Cancer Research Institute, Slovak Academy of Science, Bratislava, Slovakia. #509 ADDUCTION KINETICS OF 4-HYDROXY-2- NONENAL ON HUMAN SERUM ALBUMIN. #516 STUDIES OF CYTOTOXICITY, M. E. Szapacs, J. N. Riggins, L. J. Zimmerman and GENOTOXICITY AND APOPTOSIS CAUSED D. C. Liebler. Biochemistry, Mass Spectrometry BY C6-C9-ALDEHYDES IN A549 CELLS. Research Center, Vanderbilt University, Nashville, V. H. Mersch-Sundermann, E. Hepfner and T. TN. Stahl. Department of Indoor and Environmental Toxicology, University of Giessen, Giessen, #510 ABSENCE OF GST-Π INCREASES Germany. Sponsor: J. Pauluhn. SENSITIVITY OF MALE MICE TO THE ENVIRONMENTAL ALDEHYDE ACROLEIN. #517 IN VIVO GENOTOXIC EFFECT OF D. J. Conklin1, A. Bhatnagar1 and R. Prough2. HEXAVALENT CHROMIUM IN RAT 1Cardiology, University of Louisville, Louisville, LEUKOCYTES USING COMET ASSAY. KY and 2Biochemistry & Molecular Biology, A. K. Patlolla1 and P. B. Tchounwou2. 1Biology/ University of Louisville, Louisville, KY. Environmental Science, Jackson State University, Jackson State University, MS and 2Biology/ Environmental Science, Jackson State University, Jackson, MS.
up-to-date information at www.toxicology.org 99 , 1 . 2 M. , M. , 3 1, , 2 A. R. H. R. D. R. D. and , M. Shaw GENE 1 , R. and Research 4 , S. Yin , S. 2 4 R. Reliene Department M. Kim
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1 SUPF Biomarkers, Biomarkers, 1 , G. Li and N. Rothman and N. M. Gulumian K. Furuhama. Drug . 2 1 3 Institute of Clinical Toxicology, NIOH, Toxicology, 3 Haematology and Haematology Annual Meeting Annual 1 2 C. G. Kilty . . th 3 . M. F. Reynolds M. F. N. Galvan N. , A. J. Grosovsky A. J. , 1 R. Dixit , S. Chanock M. T. Smith T. , M. 1 2 , C. Gowdy, S. Millett, H. E. Minton, C. Gowdy,
SOT's 45 SOT's Division of Cancer Epidemiology of Cancer Epidemiology Division and T. M. Benn T. and 2 2 and M. Tikly and M. 1 Medicine, Wits, Johannesburg, South Johannesburg, Wits, Medicine, , W. Guo W. , 3 2 , L. Zhang , R. Welch , R. 2 2 , X. Masoka School of Public Health, University of California, University Health, School of Public and Chinese CDC, Beijing, China of Cell Biology and Neuroscience, University of and Neuroscience, University of Cell Biology CA. California, Riverside, TWELVE INDUCED BY MUTAGENESIS IN AGENTS ANTIBACTERIAL QUINOLONE Y. WP2UVRA/PKM101. ESCHERICHIA COLI S. Itoh, M. Kato and Hayasaki, Yeager . Department of Pathology and Laboratory. Department of Pathology Zhitkovich RI. Providence, University, Medicine, Brown IN AND REPAIR DAMAGE DNA OXIDATIVE AND SYSTEMIC PMNC OF SCLERODERMA LUPUS ERYTHEMATOSUS. S. M. Thomas S. M. Berkeley, CA, Berkeley, and S. F. Yee. Yee. Hamm and S. F. T. Bennett, J. , M. B. Leverette Greensboro, NC. Company, Tobacco Lorillard AND NON- OF OXIDATIVE ROLE TOXICITY LESIONS IN DNA OXIDATIVE OF CHROMIUM(VI). , E. Labashinsky-Heinrich and , E. Labashinsky-Heinrich Yamamoto L. Africa. Sponsor: M. Karol Bristol, United Kingdom and Kingdom. Sponsor: CONDITIONS. MA. THE ON THE EFFECT OF NITRIC OXIDE OF AND CYTOTOXICITY MUTAGENICITY CIGARETTE SMOKE CONDENSATE. 2 Africa, South Johannesburg, Africa and POLYMORPHISMS IN BRCA2 AND WRN, WRN, AND IN BRCA2 POLYMORPHISMS BENZENE AND GENOMIC INSTABILITY HEMATOTOXICITY. 1 3 Angeles, CA. . UCLA, Los Schiestl OF CIGARETTE GENOTOXICITY VARIOUS SMOKE COLLECTED UNDER DETECTION OF OXIDATIVE DAMAGE DAMAGE DETECTION OF OXIDATIVE IN CELLS CULTURES IN NEURONAL FORMAT. MICROTITER and Enterprise Development, University of Bristol, University and Enterprise Development, safety research laboratory, Daiichi Pharmaceutical safety research laboratory, Japan. Tokyo, Co., Ltd., TOBACCO EFFECTS OF SIDE STREAM DELETIONS. SMOKE ON DNA . Biological Engineering Division, Engineering Division, . Biological Wogan N. G. Cambridge, Technology, Massachusetts Institute of IN AD293 CELLS CO-CULTIVATED WITH AD293 CELLS CO-CULTIVATED IN MACROPHAGES. ACTIVATED and Genetics, NCI, NIH, DHHS, Bethesda, MD, DHHS, Bethesda, MD, and Genetics, NCI, NIH, Q. Lan Q. Neurosciences, University of Bristol, Bristol, United Neurosciences, University and G. Holloway. Arista Laboratories, and G. Holloway. Sheabar F. VA. Inc., Richmond, OXYGEN AND REACTIVE NITRIC OXIDE OF SPECIES MUTAGENESIS Vermeulen Molecular Medicine, Wits, Johannesburg, South Johannesburg, Wits, Molecular Medicine, Biotrin International, Dublin, Ireland, Biotrin International, Ireland, Dublin,
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S. S. 2 , , J. Morin , J. 1, 2 3 . J. P. P. and J. 3 Laboratory CIT, Evreux, CIT, 2 Department of 3 4 , E. Peterson-Roth , C. Goebel INSERM U644, 1 . 1 . 4 A. L. Holmes
, H. Haddouk , W. L. Lingle W. , Product Safety, Wella AG, AG, Wella Product Safety, 1, 2 2 The Tumor Biology Program, Program, Biology Tumor The 1, 2 3 , L. Richoz 1 A. Zhitkovich M. Gonsebatt TOXICOLOGY, Cosmital SA, Cosmital TOXICOLOGY, 1 H. M. Lantum Maine Center for Toxicology and Toxicology Maine Center for . 2 2 African Society for Toxicological Toxicological African Society for 4 and Wise Laboratory of Environmental and Laboratory Environmental of Wise 3 1 . , S. J. Sandwick , S. J. . Pharmacology & Toxicology, Toxicology, & States. Pharmacology and J. 1, 2 1, 2, 4 Applied Medical Sciences, University of Southern Applied Medical Sciences, University ME. Maine, Portland, P53- ARSENITE CO-EXPOSURE DISRUPTS BPDE INDUCED TO RESPONSES MEDIATED IN HUMAN LUNG CELLS. DAMAGE DNA Wise Faculte de Medecine, Rouen, France, de Medecine, Rouen, France, Faculte University of Louisville, Louisville, KY. University DNA- OF CHARACTERIZATION ADUCTS INDUCED BY CYTOKERATIN Marly, Switzerland and Switzerland Marly, LEAD TO EXPOSURE CHRONIC CENTROSOME CAUSES CHROMATE IN ANEUPLOIDY AND AMPLIFICATION MUTAGENICITY OF BENZYL CHLORIDE IN MUTAGENICITY TEST DEPENDS ON EXPOSURE AMES THE . Texas A&M University, College College A&M University, Texas . and K. C. Donnelly TX. Station, . Brown University, Providence, RI. Providence, University, . Brown and M. Reynolds ADDUCT OF DNA COMPARISON INFANT IN LIVER FROM FORMATION WITH TREATED B6C3F1 MALE MICE A RECONSTITUTED AND BENZO(A)PYRENE M. R. Smith, R. Phillips, D. T. MIXTURE. PAH A. M. C. Naspinski, L. Cizmas, A. Lingenfelter, McDonald J. T. Gillespie, Z. S. Naufal, G. Zhou, CONDITIONS. M. Fall P. Ramirez, M. Hernandez, N. Ramirez, M. Hernandez, N. ARSENIC. P. de Facultad Vargas. and G. Vera Gonzalez, R. Cuatitlan, Estudios Superiores Cuatitlan, UNAM, Sponsor: Mexico. Division of Experimental Pathology, Mayo Clinic Mayo of Experimental Pathology, Division MN and Rochester, and Foundation, Jiang HUMAN LUNG CELLS. EFFECTS OF SKIN METABOLISM ON THE ON EFFECTS OF SKIN METABOLISM AROMATIC OF POTENTIAL GENOTOXIC A. Zeller AMINES. and S. Pfuhler INFLUENCE OF SOLVENTS ON AMES II ON INFLUENCE OF SOLVENTS OF DIFFERENT CARBOXYLIC RESULTS K. Braun, H. Amberg, A. HALIDES. ACID A. and H. Spirkl, I. Stammberger Kauffmann, Sanofi-Aventis, Czich. Drug Safety Evaluation, Sponsor: M. Bonnefoi Hattersheim, Germany. Sciences (ASTS), Rochester, NY. Sciences (ASTS), Rochester, OF CHROMIUM- ABNORMAL PROCESSING REPAIR ADDUCTS BY MISMATCH DNA OF GENOTOXICITY ACTIVATES PROTEINS CHROMIUM(VI). Environmental Health, University of Southern Health, University Environmental ME, Maine, Portland, Wise R. Forster Darmstadt, Germany. Sponsor: R. Fautz Sponsor: Darmstadt, Germany. France and France of Toxicology and hydrology, Faculte de Medecine, Faculte and hydrology, Toxicology of Senegal, Dakar, of Dakar, University Genetic Toxicology, University of Southern of Maine, University Toxicology, Genetic ME, Portland, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #535 9, 10-PHENANTHRENEQUINONE (9, 10-PQ) #542 REPAIR OF 4-(METHYLNITROSAMINO)-1- INDUCES DNA DELETIONS VIA OXIDATIVE (3-PYRIDYL)-1-BUTANONE(NNK)–INDUCED AND NON-OXIDATIVE MECHANISMS IN PYRIDYLOXOBUTYLATION BY THE YEAST S. CEREVISIAE. C. Rodriguez1, NUCLEOTIDE EXICISION REPAIR(NER). Z. Sobol2, A. Cho1, J. Fukuto1 and R. Schiestl2. P. J. Brown, L. L. Bedard and T. E. Massey. 1Pharmacology, David Geffen School of Medicine Pharmacology and Toxicology, Queen, Kingston, at UCLA, Los Angeles, CA and 2Pathology, David ON, Canada. Geffen School of Medicine at UCLA, Los Angeles, CA. #543 VARIATION IN BIOLOGICAL EFFECTS OF EXPOSURE TO DIFFERENT #536 THE MOUSE LYMPHOMA ASSAY DETECTS NANOPARTICLES. M. R. Gwinn, S. S. Leonard RECOMBINATION, DELETION AND and V. Vallyathan. Pathology and Physiology ANEUPLOIDY. J. Wang1, 2, J. R. Sawyer3, M. Research Branch, Health Effects Laboratory Honma4 and M. M. Moore1. 1DGRT, NCTR, Division, National Institute for Occupational Safety Jefferson, AR, 2Department of Pharmacology and & Health, Morgantown, WV. Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 3Department of #544 ATM AND MRE11 ARE INVOLVED IN THE Pathology, University of Arkansas for Medical REPAIR OF PARTICULATE CHROMIUM (VI) Sciences, Little Rock, AR and 4Division of Genetics –INDUCED DNA DOUBLE STRAND BREAKS. 1, 2 3 1, 2 3 and Mutagenesis, National Institute of Health H. Xie , S. Dako , S. S. Wise , S. P. Katsifis and 1, 2 1 Sciences, Tokyo, Japan. J. P. Wise . Wise Laboratory of Environmental and Genetic Toxicology, University of Southern #537 HNO INDUCES DNA DELETIONS IN THE Maine, Portland, ME, 2Maine Center for Toxicology YEAST S. CEREVISIAE. N. Cook1, Z. Sobol2, and Environmental Health, University of Southern J. Fukuto1 and R. H. Schiestl2. 1Pathology, David Maine, Portland, ME and 3Department of Biology, Geffen School of Medicine at UCLA, Los Angles, University of Bridgeport, Bridgeport, CT. CA and 2Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA. #545 PARTICULATE CHROMIUM INDUCED DNA-DNA CROSSLINKS LEAD TO #538 IONIZING RADIATION AND RESTRICTION CHROMOSOME DAMAGE. L. C. Savery1, 2, S. ENZYMES INDUCE MICROHOMOLOGY- S. Wise1, 2 and J. P. Wise1, 2, 3. 1Wise Laboratory of MEDIATED ILLEGITIMATE Environmental and Genetic Toxicology, University RECOMBINATION IN TRANS IN YEAST. C. of Southern Maine, Portland, ME, 2Maine Center for
Y. Chan, M. Kiechle, P. Manivasakam and R. H. Toxicology and Environmental Health, University of MONDAY Schiestl. Pathology, UCLA, Los Angeles, CA. Southern Maine, Portland, ME and 3Department of Applied Medical Sciences, University of Southern #539 RESEARCH ON CHROMOSOMAL Maine, Portland, ME. ABERRATIONS IN HUMAN SPERM AND LYMPHOCYTES EXPOSED TO LARGE-DOSE #546 DOSE-RESPONSE COMPARISON OF IRRADIATION. Y. Lu, B. Fu, Y. Chen and L. MICRONUCLEATED RETICULOCYTE Han. Toxicology, Henan Institute of Occupational FREQUENCIES IN RODENT PERIPHERAL Medicine, Zhengzhou, Henan, China. Sponsor: Y. BLOOD WITH FOUR GENOTOXIC AGENTS Wu. BY FLOW CYTOMETRY AND SLIDE-BASED ENUMERATION. L. Recio1, W. Caspary2, D. #540 THE ANTIRETROVIRAL ZIDOVUDINE Tourous4, E. Livanos1, G. Kissling3 and K. Witt2. ALTERS THE CELL CYCLE AND INDUCES 1Genetic Toxicology, ILS, Research Triangle Park, METABOLIC RESISTANCE IN HUMAN NC, 2Environmental Toxicology Program, NIEHS, LYMPHOBLASTOID CELLS EXPOSED Research Triangle Park, NC, 3Biostatistics Branch, LONG-TERM IN VITRO. O. Olivero, J. M. Ming, NIEHS, Research Triangle Park, NC and 4Litron I. L. Vazquez, E. J. Robinson and M. C. Poirier. Laboratories, Rochester, NY. National Cancer Institute, Bethesda, MD. #547 EFFECTS OF FEEDER CELLS ON THE #541 A LOW DNA REPAIR CAPACITY IS COLONY GROWTH AND MORPHOLOGICAL ASSOCIATED WITH NON-MELANOMA SKIN TRANSFORMATION IN THE SHE CELL CANCER TUMORS IN SUN-PROTECTED TRANSFORMATION ASSAY. Y. Xu, N. Gibson, 1 AREAS OF THE BODY. J. L. Matta , J. F. Luo, G. Borneo and T. E. Lawlor. Genetic & 1 1 2 3 Ramos , A. Ruiz , J. Villa and R. Armstrong . Molecular Toxicology, Covance Laboratories, 1 Pharmacology, Physiology & Toxicology, Ponce Vienna, VA. School of Medicine, Ponce, USA, Puerto Rico, 2Parras Building, Damas Hospital, Ponce, USA, #548 IDENTIFICATION OF GENE EXPRESSION Puerto Rico and 3Marine Sciences, University of SIGNATURE AND A NOVEL MARKER, Puerto Rico, Mayaguez Campus, Mayaguez, USA, DOG1, FOR GENOTOXICITY BY GENE Puerto Rico. EXPRESSION PROFILING. J. Hu, D. Aud, K. Chakravarty, S. Fu, J. Wang, J. Allard, G. Liao, J. Usuka, K. Dolim, Z. Zhang and G. Peltz. Genentics & Genomics, Roche Palo Alto, Palo Alto, CA. up-to-date information at www.toxicology.org 101 .
2 IN . and 1 2 and B. B. 3 P. J. J. , P. 2
, G. Jun and P. Scott , P. 1 J. Aubrecht , J. and D. Gibson and D. 1 . MB Research 1 L. S. Birnbaum Annual Meeting Annual and , M. Aardema , M. th 2 1 ChemRisk, Pittsburgh, ChemRisk, Pittsburgh, 3 , N. Wilt , N. 2 B. D. Kerger D. , B. Pfizer Worldwide Safety PfizerWorldwide R. D. Leverette , R. D. 2 2 HSRI, Inc., Tallahassee, FL, Tallahassee, HSRI, Inc., 1 . , T. Hu T. , 4 1 SOT's 45 SOT's R. D. Curren R. D. , D. F. Staskal F. , D. ASSAY DETECTS CHEMICALS ASSAY 1 H. Leung TM TM
Pfizer and Development, Global Research J. M. Grundy M. and J. Spencer, J. J. , P. 1 Curriculum in Toxicology, University of University Toxicology, Curriculum in , G. Mun ChemRisk, San Francisco, CA. ChemRisk, San Francisco, . 2 S. V. Vulimiri V. S. 3 4 1 . Procter & Gamble Co., Cincinnati, OH and Procter & Gamble 2 NHEERL ORD, U.S. EPA, Research Triangle Park, Park, Triangle Research EPA, U.S. NHEERL ORD, Institute for In Vitro Sciences, Inc., Gaithersburg, Sciences, Inc., Gaithersburg, Vitro Institute for In MA. Ashland, Corporation, MatTek CT, Consultant, Danbury, PA and PA D. J. Paustenbach J. D. Diliberto J. J. . Toxicology & Environmental Research & Environmental Toxicology . Waechter Chemical Company, The Dow and Consulting, MI. Midland, PAPER THE EFFECT OF CIGARETTE ON CIGARETTE SMOKE POROSITY MICRONUCLEI CONDENSATE-INDUCED Lorillard Spears Research Center, A.W. Yee. S. F. Greensboro, NC. Company, Tobacco A NON-RADIOACTIVE OF VALIDATION UNSCHEDULED CYTOMETRY-BASED FLOW A. Kirk, C. ASSAY. (FL-UDS) SYNTHESIS DNA AN INTEGRATED TOXICOKINETIC MODEL TOXICOKINETIC AN INTEGRATED CHILDHOOD BODY FOR ESTIMATING VARIOUS ON BASED OF DIOXINS BURDENS Labs, Spinnerstown, PA. Labs, Spinnerstown, MICRONUCLEUS NOVEL A OF EVALUATION A HUMAN 3-D SKIN MODEL, USING ASSAY MD, VITOTOX VITRO TISSUE DISPOSITION OF BDE 47 IN MICE. 1 NC and EPIDERM Hayden 1 3 WIDE RANGE OF GENOTOXIC A WITH A. Hendricks MECHANISMS. C. K. Lam Cambridge, MA and STUDIES. 2 INFLUENCE OF NON-CHEMICALLY INFLUENCE OF NON-CHEMICALLY ON INDUCED HYPOTHERMIA DOSES OF PHENOL SUBHYPOTHERMIC OF MICRONUCLEI FORMATION THE IN THE MOUSE BONE MARROW. (MN) IN Gollapudi L. DeGeorge M. K. Reeder and G. Sciences, Groton, CT. North Carolina, Chapel Hill, NC. DEVELOPMENTAL AGE EFFECTS ON AGE DEVELOPMENTAL
1:30 PM–4:30 PM 3:00 PM–4:30 PM (Continued) Annual Annual th #557 #558 #561 #559 #560 1:30 PM to 4:30 PM Exhibit Hall TOXICOKINETICS/PHARMACOKINETICS POSTER SESSION: MD. Ground, Proving Aberdeen Army, U.S. Chairperson(s): Gunda Reddy, Displayed: Attended: #556 Monday, March 6 March Monday, #562 45 102 . , , 2 , R. 1 Meeting & ToxExpo & Meeting C. , 1 , 3 , 1 2 . 1
1 R. N. W. W. , N. , 2 1 Center 2 General 2 , P. Pezzoli , P. 1 Pathology, Pathology, 1 . S. G. Sawant G. S. Pharmacology Pharmacology 1
, V. O. Wagner O. V. , 1 2 , Z. Medverec Chemistry, Chemistry, A. J. Bourdelais , A. J. . 2 3 , S. Young , S. M. Cosenza 1 4, 1 , 1, 4 1 and J. Monforte and J. 2 State University of New of New State University 1 Toxikon Corporation, Toxikon 1 M. L. Yamamoto M. L. . 1 . , N. Leko , N. 2 3 , L. Desai Covance Inc., Vienna, VA and VA Vienna, Inc., Covance Environmental and Molecular Environmental 1 2 4 Toxicology, Amgen Inc., Toxicology, and R. Schiestl G. L. Erexson , G. 1 2 , G. Fogel OXiGENE, Waltham, MA. Waltham, OXiGENE, 2 1 2 . 1 C. A. Afshari A. , C. Evolutionary Computation, Natural 1 2 J. E. Gibson and J. 2, 3 , B. Jelakovic , B. 1 , J. Bibay , J. Pathology, University of Washington, Washington, of University Pathology, , H. Murli , T. Day T. , 1 2 , J. Oshima , J. 1 and S. Shibutani 1 1 1 J. C. Randall and J. 2 School of Medicine, University of Zagreb, School of Medicine, University 3 BioReliance Corp., Rockville, MD. eXpress Profiling, Althea Technologies, Inc., San Technologies, eXpress Profiling,Althea and Toxicology, The Brody School of Medicine, Toxicology, and NC, Greenville, East Carolina University, Bedford, MA and Bedford, University of California, Los Angeles, Los Angeles, Angeles, Los California, of Los University Hurst York at Stony Brook, Stony Brook, NY, Brook, NY, Brook, Stony at Stony York K. Nam Marque D. and T. Thousand Oaks, CA, 3 R. Iden and INFLUENCE OF IMPURITIES ON A DRUG FINDINGS OF GENOTOXICITY STUDY. CASE A – CANDIDATE G. Vansant NON-CARCINOGENIC? G. A. Birch 1 Diego, CA and Diego, Raleigh, NC. TOXICOLOGICAL EARLY AND CHARACTERIZATION OF CANDIDATE CLASSIFICATION THROUGHPUT A HIGH COMPOUNDS IN USING NEURAL NETWORKS, FORMAT AN AND ANALYSIS, GENE EXPRESSION SESSION: CELL PLATFORM VITRO IN OR NON-GENOTOXIC?, GENOTOXIC?, STUDIES ON THE CHEMOPREVENTIVE STUDIES ON INDUCED BY BREVETOXIN DAMAGE DNA FIVE FROM 2 IN HUMAN LYMPHOCYTES Murrell R. N. VOLUNTEERS. (RUCOLA) AND (RUCOLA) SATIVA EFFECT OF ERUCA IN HUMAN CELL ITS ISOTHIOCYANATES Voelkel Y. Schroeder, F. J. E. Lamy, CULTURES. H. Mersch-Sundermann. Department of V. and of University Toxicology, Indoor and Environmental (?) Pauluhn Sponsor: J. Giessen, Giessen, Germany. EFFECTS OF HUMAN MUTANT WERNER MUTANT EFFECTS OF HUMAN ON DNA EXPRESSION PROTEIN DELETIONS IN MICE. Reliene CA and Selection Inc., San Diego, CA. Selection Inc., San Diego, OF ENDEMIC TOXICOGENOMICS Grollman A. P. IN CROATIA. NEPHROPATHY University of North Carolina at Wilmington, Wilmington, of North Carolina at University NC and Wilmington, T. Dunn T. D. G. Baden G. D. Hospital Dr.Josip Bencevic, Slavonski Brod, Croatia Brod, Slavonski Bencevic, Hospital Dr.Josip Zagreb, Croatia. for Marine Science, University of North Carolina for Marine Science, University NC, Wilmington, Wilmington, at Chen J. J. Seattle, WA. Seattle, AND CLASTOGENIC OF MUTAGENIC LACK A-4 OF COMBRETASTATIN ACTIVITY DESTABILIZING (CA4)–A MICROTUBULE Sadhu N. D. AGENT. Toxicology, North Carolina State University, North Carolina State University, Toxicology, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #563 CHANGES IN MOUSE RENAL #572 AGE- AND DOSE-DEPENDENT TISSUE TRANSPORTER EXPRESSION IN RESPONSE DISTRIBUTION OF DELTAMETHRIN (DLM) TO ACETAMINOPHEN. M. E. Blake-Kinnin1, IN MALE SPRAGUE-DAWLEY (S-D) RATS. K. L. M. Aleksunes1, L. Augustine2, N. J. Cherrington2 Kim1, 2, J. V. Bruckner1 and H. Kim1. 1Department of and J. E. Manautou1. 1Department of Pharmacology Pharmaceutical and Biomedical Sciences, University Sciences., University of Connecticut, Storrs, CT of Georgia, Athens, GA and 2Pharmacology and 2Department of Pharmacology and Toxicology, Department, National Institute of Toxicological University of Arizona, Tucson, AZ. Research, Korea Food and Drug Administration, Seoul, South Korea. #564 ENDOCRINE REGULATION OF GENDER DIVERGENT EXPRESSION OF MOUSE #573 EFFECTS OF ORGANIC ANION TRANSPORTING PERFLUOROOCTANESULFONATE ON 125I POLYPEPTIDES (OATPS). X. Cheng, J. Maher, ELIMINATION IN RATS AFTER A SINGLE H. Lu and C. D. Klaassen. Pharmacology & INTRAVENOUS DOSE OF 125I-LABELED Toxicology, KUMC, Kansas City, KS. THYROXINE. S. Tanaka1, M. Eastvold2, E. Foshay1, J. Hart1 and J. Butenhoff1. 13M Company, #565 TOXICOKINETICS OF P-OCTYLPHENOL St. Paul, MN and 2Mayo Medical Laboratories, IN MALE AND FEMALE SPRAGUE-DAWLEY Rochester, MN. RATS. G. Hamelin, K. Krishnan and R. Tardif. Occupational and Environmental Health, University #574 ACCUMULATION OF NEUROTOXIC of Montréal, Montréal, QC, Canada. METABOLITES OF 3, 4-(±) METHYLENEDI OXYMETHAMPHETAMINE IN RAT BRAIN #566 DISPOSITION AND ELIMINATION FOLLOWING MULTIPLE DOSING. G. V. OF TUNGSTEN AFTER ORAL AND Erives, S. S. Lau and T. J. Monks. Pharmacology and 1 INTRAVENOUS EXPOSURES. R. Marr , R. Toxicology, University of Arizona Health Science 2 1 1 Arimoto and J. McDonald . Toxicology, Lovelace Center, Tucson, AZ. Respiratory Research Institute, Albuquerque, NM and 2Chemistry, CEMRC, Carlsbad, NM. #575 BRAIN METABOLISM OF ACRYLONITRILE TO CYANIDE: IN VITRO STUDIES. O. S. #567 COMPARATIVE DISPOSITION OF N, N- El-Tawil1, A. M. Mohamadin2, A. B. Abdel- DIMETHYL-p-TOLUIDINE (DMPT) IN MALE Naim3 and A. H. Abou-Hadeed4. 1Department of AND FEMALE FISCHER 344 RATS AND Toxicology and Forensic Medicine, Faculty of B6C3F1 MICE. K. J. Dix, K. Ghanbari and B. Veterinary Medicine, Cairo University, Cairo,
M. Hedtke-Weber. Lovelace Respiratory Research Egypt, 2Tumor Marker Oncology Research Unit, MONDAY Institute, Albuquerque, NM. Department of Biochemistry, Faculty of Pharmacy, 3 #568 DETERMINATION OF ACESULFAME-K Al-Azhar University, Cairo, Egypt, Department CONCENTRATIONS AND PRELIMINARY of Pharmacology and Toxicology, Faculty of PHARMACOKINETICS IN C57BL MOUSE Pharmacy, Ain Shams University, Cairo, Egypt and 4 PLASMA AND URINE. J. Lodge1, B. Fletcher1, Department of Forensic Medicine and Toxicology, D. Brine1, J. Pittmen1, C. Harris1, S. Cooper1, Faculty of Veterinary Medicine, Zagazig University, S. Anderson1, B. Collins2 and C. Garner1. 1RTI Zagazig, Egypt. International, Research Triangle Park, NC and #576 EVALUATION OF PERFLUOROOCTANE 2 National Institute of Environmental Health SULFONATE IN THE RAT BRAIN. C. Lau1, J. R. Sciences, Research Triangle Park, NC. Thibodeaux1, K. Das1, D. J. Ehresman2, S. Tanaka2, 3 2 1 #569 OXIDATIVE AND HYDROLYTIC J. Froehlich and J. L. Butenhoff . Reproductive METABOLISM OF TYPE I PYRETHROIDS Toxicology Division, NHEERL, ORD, U.S. EPA, 2 IN RAT LIVER MICROSOMES. E. J. Scollon1, Research Triangle Park, NC, Medical Department, 3 J. M. Starr2, M. F. Hughes1 and M. J. Devito1. 1ORD/ 3M Company, St. Paul, MN and Department of NHEERL/ETD, U.S. EPA, Research Triangle Park, Chemistry, University of California, Davis, CA. 2 NC and ORD/NERL/ETD, U.S. EPA, Research #577 AHR MEDIATED HEMATOTOXICITY IS Triangle Park, NC. INDUCED AT THE SITE OF BONE MARROW #570 IMPLICATIONS OF AGE-DEPENDENT HALF WHERE CONSEQUENT CYP2E1-DERIVED LIVES OF DIOXINS ON ASSESSMENT OF BENZENE METABOLITES LOCALLY 1 BREAST MILK DOSE AND BODY BURDEN. INDUCE THEIR TOXICITY. Y. Hirabayashi , 1 1 2 1 R. O. Richter2, B. D. Kerger1, H. Leung4 and D. B. Yoon , G. Li , Y. Fujii-Kuriyama , T. Kaneko , 1 3 1 J. Paustenbach3. 1HSRI, Inc., Tallahassee, FL, J. Kanno and T. Inoue . Cell & Mol Toxicology 2 2Exponent, Irvine, CA, 3ChemRisk, San Francisco, Division, NIHS, Tokyo, Japan, TARA, University of 3 CA and 4Consultant, Danbury, CT. Tsukuba, Tukuba, Japan and CBSR, NIHS, Tokyo, Japan. #571 THE PHARMACOKINETICS OF DEET IN THE MOUSE. W. McGuinn1, M. Peden-Adams2, #578 TOXICOKINETIC - TOXICODYNAMIC J. EuDaly2, G. Gilkeson2 and D. Keil3. 1U.S. FDA, RELATIONSHIPS IN CASES OF FIPRONIL Silver Spring, MD, 2MUSC, Charleston, SC and EXPOSITION. A. Anadon, M. R. Martinez- 3UNLV, Las Vegas, NV. Larranaga, M. A. Martinez, V. Caballero, M. J. Diaz, M. Martinez and R. Pita. Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain. up-to-date information at www.toxicology.org 103 . L. , R. K. , R. 1 . 1 , and M. F. and M. F. , A. , E. Zahalka 2 1 L. Jia and C. S. , 1 A. M. Solyom , R. L. Mathias 1 Annual Meeting Annual th A. Sierra-Santoyo A. B. Astroff , A. B. H. A. Barton , H. 1 Life Sciences Division, Life Sciences Division, 2 1 PKB, U.S. EPA, ORD, ORD, EPA, U.S. PKB, . 2 , J. W. Algaier W. , J. 2 1 . SOT's 45 SOT's . Health and Enviromental K. Plotzke. Health and Enviromental , D. C. Messer , D. 1 Toxicology, CINVESTAV-IPN, Mexico Mexico CINVESTAV-IPN, Toxicology, 1 , B. C. Edwards , B. 2 , R. K. Harris . 1 2 B. Jayaram and B. 2 Environmental Toxicology Program, NIEHS, Program, Toxicology Environmental 2 City, D.F., Mexico and Mexico D.F., City, Midwest Research Institute, Kansas City, MO Research Institute, Kansas City, Midwest National Cancer DTP/DCTD, Tomaszewski. E. J. Sponsor: Institute/NIH, Rockville, MD. Sciences, Dow Corning Corporation, Midland, MI. Corning Corporation,Sciences, Dow Midland, OF AND DOSIMETRY METABOLISM VINCLOZOLIN IN RAT. Smith and Hughes The of Medicine, College I. Sipes. Pharmacology, AZ. Tucson, Arizona, of University DISPOSITION OF IN A (TBBPA) TETRABROMOBISPHENOL MALE FISCHER-344 RATS. The of Medicine, College I. Sipes. Pharmacology, AZ. Tucson, Arizona, of University TOXICOKINETIC PRELIMINARY METHOD ANALYTICAL AND STUDY IN DEVELOPMENT FOR BETA-MYRCENE Schebler J. PLASMA. P. RAT Sponsor: R. Harling Shaikh, K. C. Hornbuckle, N. MICE. I. Korwel, of Iowa, University Robertson and H. Lehmler. W. IA. City, Iowa DISPOSITION OF 14C- (14C-HMDS) HEXAMETHYLDISILOXANE FOLLOWING IN MALE FISCHER 344 RATS INHALATION AND REPEATED SINGLE S. Tobin, McNett, J. Durham, D. EXPOSURE. J. Crofoot and INFLUENCE OF THE ROUTE OF THE ROUTE INFLUENCE OF ENANTIOMERIC THE OF ADMINISTRATION 136 IN MALE C57BL/6 OF PCB FRACTION Y. A. Shan Y. Harrison Pacific Monitoring and Modeling, Biological WA. Richland, National Laboratory, Northwest AND EXCRETION OF DISPOSITION 3- A BIS[2, TETRABROMOBISPHENOL ETHER] (TBBPA-DBPE) DIBROMOPROPYL A. Knudsen, G. IN MALE FISCHER-344 RATS. Rodriguez, A. M. Solyom P. V. , R. K. Kuester , V. P. Rodriguez, L. Jacobs, C. J. Sweet and Sweet Rodriguez, L. Jacobs, C. J. P. V. , Kuester NC. Park, Triangle Research OF PROFILE TOXICOKINETIC DOGS. IN BEAGLE BATRACYLIN DISTRIBUTION OF ANTICANCER DRUGS ANTICANCER DRUGS OF DISTRIBUTION ASSESSMENT AN TUMOURS INTO WHOLE-BODY USING QUANTITATIVE H. A. Lathall, C. Henson, AUTORADIOGRAPHY. BioDynamics Wood. and S. G. McEwen A. B. Bird, Rushden, United Kingdom. Research Limited, NHEERL and NCCT, Research Triangle Park, NC. Park, Triangle Research NHEERL and NCCT, OF DERMAL UPTAKE COMPARISON MODEL FOR PHARMACOKINETIC DATA M. P. A. Gies, R. DEVELOPMENT IN RATS. Thrall and K. D. Woodstock A. D. , Hinderliter P. Clark P.
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1 1 2 .
1 , 1 - , E. . K. D. , K. D. 1 1 β College College , J. , J. 2 Florida 1 University University 4 IN 3 Battelle, , S. Sager 1 2 and E. Seo . 1 1 , F. Chaurand , F. Toxicology Toxicology , H. Wu , H. 1, 2 C. Banks , R. J. Clarkson , R. J. 2 1 and A. and 2 , G. Statom 3 1 E. Jeong , J. Ha , J. , A. D. Woodstock A. D. , 1 1 . Arcadis G&M of Veterinary Services, Veterinary 2 1 . 2 , R. Clarkson 2 , J. Lee , J. T. S. Poet and T. D. Baden , D. 2 1 2 B. van Ravenzwaay and B. B. J. Locey J. , B. , A. Gómez , 2 1 1 CDC, Atlanta, GA, CDC, 2 Battelle, Pacific Northwest 1 , C. M. Carosino 1 . . 1 , W. Kang W. , B. J. Locey J. , B. , L. Kendall, D. Schnell, C. D. , L. Kendall, M. Grant D. 1 1 and E. Troncy and E. , L. Backer 1 J. Benson J. 1 C. Hastings I. Dean R. A. Corley , R. Lovelace Respiratory Research Institute, Lovelace , 2 1 1 , J. J. Soelberg J. , J. . 1 4 , Q. Jin , Q. Biomedicine, Faculty of Veterinary Medicine, Veterinary of Biomedicine, Faculty 1 2 Experimental Toxicology and Ecology, BASF BASF and Ecology, Toxicology Experimental Arcadis G&M of Michigan, LLC, Southfield, MI. Arcadis G&M of Michigan, Pharmacokinetics & Toxicokinetics, Korea Institute Korea Toxicokinetics, Pharmacokinetics & Albuquerque, NM, Albuquerque, LAB. Preclinical Research, Laval, QC, Canada Preclinical Research, Laval, LAB. ENDOSCOPY FOR INTRADUODENAL ENDOSCOPY FOR INTRADUODENAL COMPARISON ADMINISTRATION: DRUG IN ANESTHETIC PROTOCOLS THREE OF AND DOGS BEAGLE MINIPIGS, GOTTIGEN METABOLISM OF 1, 4-DIOXANE. OF 1, METABOLISM VITRO and WA Pacific Richland, Division, Northwest B. Tibbetts B. and WA Richland, Division, HYDROXYETHOXYACETIC ACID, IN MALE ACID, HYDROXYETHOXYACETIC MINIMALIST SAMPLING STRATEGIES FOR STRATEGIES MINIMALIST SAMPLING A RETROSPECTIVE TOXICOKINETICS: ANALYSIS. Leibold 1 J. J. Soelberg J. B6C3F1 MICE. J. Thrall and K. D. and Ludwigshafen, Germany AG, Reich A. D. Woodstock A. D. S. Sager 2 OF BREVETOXIN TRANSPORT PLACENTAL IN MICE. S. Authier RHESUS MONKEYS. S. and Sponsor: 1 and South Korea Daejeon, Toxicology, of S. Fournier Kim PREVENTING THE CONTAMINATION THE CONTAMINATION PREVENTING TEST SAMPLES BY OF CONTROL TOXICOKINETIC DURING ARTICLE Toxicology, H. Devine. INVESTIGATIONS. Laboratories Preclinical Montréal, Charles River QC, Canada. Sponsor: Senneville, Michigan, LLC, Southfield, MI. Michigan, A EXCRETION OF OF RENAL SATURATION HERBICIDE ACID BENZOIC CHLORINATED A DETERMINE TO AN EXAMPLE AS E. Fabian MTD. BASED KINETICALLY COMPARATIVE RAT AND MOUSE AND RAT COMPARATIVE Langer and K. Lee. Pfizer, Groton, CT. Inc., A SELECTIVE METHOD OF VALIDATION OF DOXIFLURIDINE FOR DETERMINATION PLASMA IN DOG AND 5-FLUOROURACIL THE TO APPLICATION BY LC-MS/MS: STUDY. BIOEQUIVALENCE University of Montréal, St-Hyacinthe, QC, Canada. of Montréal, St-Hyacinthe, University and Ecotoxicology, BASF Corporation, Research BASF and Ecotoxicology, NC. Park, Triangle Department of Health, Tallahassee, FL. Tallahassee, Department of Health, OF 1, THE PHARMACOKINETICS AND ITS METABOLITE, 4-DIOXANE of North Carolina, Wilmington, NC and Wilmington, of North Carolina, A. Corley R. of Pharmacy, Catholic University of Daegu, Daegu, Daegu, of Daegu, Catholic University of Pharmacy, Koh Sponsor: W. South Korea. Thrall 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #596 EFFECT OF AGE ON TISSUE DISTRIBUTION #603 THE PHARMACOKINETICS OF PERFL OF BDE 47 IN MICE. D. Staskal1, J. J. Diliberto2 UOROOBUTANESULFONATE (PFBS) IN and L. S. Birnbaum2. 1Curriculum in Toxicology, MONKEYS AND HUMANS. G. Olsen1, P. Lieder1, UNC- Chapel Hill, Research Triangle Park, NC and P. Noker2, G. Gorman2 and J. Butenhoff1. 13M 2ORD, NHEERL, ETD, U.S. EPA, Research Triangle Company, St. Paul, MN and 2Southern Research Park, NC. Institute, Birmingham, AL. #597 ESTIMATING CONSTANTS FOR #604 PHARMACOKINETICS OF 3-(4-METHY METABOLISM OF ATRAZINE IN PRIMARY LBENZYLIDENE)CAMPHOR IN HUMAN RAT HEPATOCYTES BY KINETIC SUBJECTS. Universtiy of. M. Schauer1, T. MODELING. T. S. McMullin1, 3, W. H. Hanneman1, H. Broschard2 and W. Dekant1. 1Department of B. Cranmer1, J. D. Tessari1 and M. E. Andersen2. Toxicology, University of Wüerzburg, Wüerzburg, 1Environmental and Radiological Health Sciences, Germany and 2Department of Toxicology, Merck Colorado State University, Fort Collins, CO., 2CIIT, KGaA, Darmstadt, Germany. Centers for Health Research, Research Triangle Park, NC and 3Toxicology and Environmental #605 TOXICOKINETICS OF CKD-501 AFTER 13- Research and Consulting, The Dow Chemical WEEK ORAL ADMINISTRATION IN RATS. 1 1 1 1 1 2 Company, Midland, MI. J. Lee , J. Ha , J. Hong , H. Lim , Q. Jin , J. Shin , I. Hwang2, H. Lee2, S. Ahn2, C. Kim1 and E. Jeong1. #598 METABOLISM AND KINETICS OF 3-(4- 1Pharmacokinetics and Toxicokinetics, Korea METHYLBENZYLIDENE)CAMPHOR IN Institute of Toxicology, Daejeon, South Korea and THE RAT: IMPACT OF THE ROUTE OF 2Chong Kun Dang Pharmacology, Seoul, South EXPOSURE. T. H. Broschard1, Universtiy of. Korea. Sponsor: W. Koh. Schauer2, A. Heusener1, G. Ziegler1, W. Dekant2, F. von Landenberg1 and P. Kramer1. 1Institute of Monday, March 6 Toxicology, Merck KGaA, Darmstadt, Germany and 1:30 PM to 4:30 PM 2Institut fuer Toxikologie, Universitaet Wüerzburg, Exhibit Hall Wüerzburg, Germany. #599 PHARMACOKINETICS AND POSTER SESSION: SAFETY EVALUATION— BIODISTRIBUTION OF A PHARMACEUTICALS 1 (NEURO, CARDIOVASCULAR, PHOSPHORODIAMIDATE MORPHOLINO ENDOCRINE/METABOLIC) OLIGOMER CONJUGATED TO AN
ARGININE-RICH PEPTIDE. A. Amantana, H. Chairperson(s): Courtney Sulentic, Wright State University, Dayton, OH MONDAY M. Moulton, M. L. Cate, M. T. Reddy, T. Whitehead, and Chudy Nduaka, Pfizer Inc., Groton, CT. J. N. Hassinger, D. D. Weller and P. L. Iversen. Displayed: 1:30 PM–4:30 PM Toxicology, AVIBioPharma, Inc., Corvallis, OR. #600 METABOLITE PROFILING OF 14C-RDX IN Attended: 1:30 PM–3:00 PM MINIATURE PIGS. G. Reddy. Health Effects #606 SAFETY OF INTRATHECAL GABAPENTIN Research Program, U.S. Army Center for Health FOR INJECTION IN RATS AND SHEEP. Promotion and Preventive Medicine, Aberdeen J. Allen1, L. Page1, G. Stewart1, T. Gradert2, S. Proving Ground, MD. Hassenbusch2, B. Satterfield2, W. Baze2 and K. Hildebrand1. 1Neurological, Medtronic, Minneapolis, #601 A TWO-PARADIGM STUDY OF MN and 2MD Anderson Cancer Center, University ORAL GAVAGE VS. DIET DOSING of Texas, Houston, TX. ON PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF A NON- #607 NEUROTOXICITY OF SOME STEROIDAL ANTI-INFLAMMATORY DRUG, ANTICONVULSANT N, N’-SUBSTITUTED SULINDAC. R. Krishnaraj1, A. Lyubimov1, SPIROHYDANTOINS. R. A. Stephani, H. J. Patel T. Martin-Jimenez2 and I. M. Kapetanovic3. and J. D. Sarra. Pharmaceutical Sciences, St. John’s 1Toxicology Research Laboratory, Department of University, Jamaica, NY. Pharmacology, University of Illinois at Chicago, Chicago, IL, 2Toxicology Research Laboratory, #608 A TWO-WEEK REPEAT DOSE TOXICOLOGY University of Illinois at Chiacgo, Chicago, IL, STUDY IN RATS WITH A ONE WEEK 3Department of Veterinary Biosciences, University RECOVERY PERIOD WITH RECOMBINANT 1 3 of Illinois urbana-Champaign, Urbana, IL and RAT NEUBLASTIN. D. R. Demady , D. Hutto , A. 2 1 1 1 4Division of Cancer Prevention, National Cancer Rossomando , K. Zokowski , C. Hurst , J. Clarke 4 1 Institute, Bethesda, MD. and K. Rao . Pharmacotoxicology, Biogen Idec Inc., Cambridge, MA, 2Protein chemistry, Biogen Idec #602 IN VIVO PHARMACOKINETIC/ Inc., Cambridge, MA, 3Veterinary and Comparative PHARMACODYNAMICS OF BACKBONE Pathology, Biogen Idec Inc., Cambridge, MA and MODIFIED 2’-MOE ANTISENSE 4Toxicology, Quintiles Inc., Kansas City, MO. OLIGONUCLEOTIDES (ASO) IN RODENTS. R. S. Geary, A. Siwkowski, J. Matson, T. Watanabe, S. P. Henry and A. A. Levin. ISIS Pharmaceuticals, Inc., Carlsbad, CA. up-to-date information at www.toxicology.org 105 , ,
1 , 1 1
T. T. 2 , J. , J. , J. , J. 1 2 . , C. 2 1 D. F. F. , D. , C. 1 . New New 1 2, 1 . 1, 2 Battelle, 3 G. Finch , G. 2 1 M. Aleo , M. , M. Shaw Orentreich 1 2 2 RECEPTOR RECEPTOR , J. W. Stocker W. , J. , C. Crean, 1 12 , C. V. Okerberg V. , C. 1 Safety Sciences, , C. E. Perrone 1 1 , B. Ballinger , B. . 1 , M. P. Smith , M. P. 2 , D. Baltrukonis , D. Annual Meeting Annual 1 2, 1 th McNeil Cons. & Spec. M. M. Yuschak and M. M. , R. Barnes 2 1 1 , R. Moutvic Elucida Research LLC, 1 , M. Reily 2 W. R. McConnell W. 1 and H. B. Haimes and H. B. Safety Sciences, PfizerSciences, Safety Global 1 M. S. Cowlen 1 , C. Liu D. G. Robertson G. and D. , G. C. Rigdon the sanofi-aventis Group, 1 Safety Sciences, Pfizer PGRD, . 1 1 3 2 3 , J. Render , J. 1 J. Singh J. SOT's 45 SOT's and R. Mason 2 J. M. DeBoef J. M. J. Iatropoulos , M. J. 1 , D. Gage , D. , T. Kawabata T. , 1 1 , C. Somps 1 , J. Fortner , J. 1 , L. C. Robosky T. B. Grizzle B. T. G. M. Williams M. , G. 1 1, 2 , R. Jacob 2 Metabonomics Evaluation Group, Pfizer Metabonomics Evaluation PGRD, Icagen, Durham, NC and Alteon Inc., Parsippany, NJ. Alteon Inc., Parsippany, Wells Columbus, and OH M. Elwell Pharmaceuticals, Fort Washington, PA. Washington, Pharmaceuticals, Fort ON INVESTIGATIONS TOXICOLOGICAL INHALED INSULIN. ANTAGONIST WITH ANTI-PLATELET ANTI-PLATELET WITH ANTAGONIST ADMINISTERED ACTIVITY, AGGREGATION INFUSION BY CONTINUOUS INTRAVENOUS DOGS. IN BEAGLE Day G. A. McNaughton-Smith G. Ann Arbor, MI and Arbor, Ann STUDY OF POTENTIAL GENOTOXIC AND GENOTOXIC OF POTENTIAL STUDY AND SAFETY CARDIOPULMONARY OF EVALUATION TOXICOLOGICAL A REVERSIBLE P2Y INS50589, and I. Stammberger I. and , N. Huang, K. Cassidy, R. Moulton and Huang, K. Cassidy, , N. Williams and Research Laboratories, Eli Lilly Hui. Lilly Y. Indianapolis, IN. Company, AND METABOLISM PHARMACOKINETICS 5-HT2C RECEPTOR A SELECTIVE OF THE OF MODIFICATION AGONIST: Y. ACTIVITY. LIMIT 5-HT2B TO STRUCTURE K. M. Reinhard, Fayer, J. Huang, K. Cassidy, Hui, N. . Lilly Research Laborotories, . Lilly Williams Briner and T. Indianapolis, IN. and Company, Eli Lilly OF EVALUATION METABONOMIC REDUCTASE AN HMG-COA CERVISTATIN, INHIBITOR. L. Egnash 1 (SCD). 1 Lapointe Doshna EPIGENETIC LIVER CANCER-INDUCING EPIGENETIC LIVER CHLORIDE ALAGEBRIUM EFFECTS OF (SD) RATS. IN SPRAGUE-DAWLEY (ALT-711) Duan NY and Cold Spring-on-Hudson, Foundation, 3 and J. Watson P. L. Richards, R. Krishnamoorthy, Durham, NC. Inspire, Boyer. OF ICA- NONCLINICAL EVALUATIONS FOR DRUG AN INVESTIGATIONAL 17043: DISEASE OF SICKLE CELL TREATMENT Ann Arbor, MI. Arbor, Ann Pfizer, Groton, CT and Research and Development, Groton, CT, CT, Groton, Research and Development, A. M. Jeffrey York Medical College, Valhalla, NY, NY, Valhalla, Medical College, York Frankfurt, Germany. OCULAR EFFECTS OF SORBITOL INHIBITOR (SDH) DEHYDROGENASE SDI-PFE. (SDI), MA. Beverly, SELECTIVE A AND KINETICS OF TOXICITY AND AGONIST 5-HT2C RECEPTOR WITH 5-HT2B- ASSOCIATED THE RISK DISEASE. HEART VALVULAR MEDIATED
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and J. C. , J. 2 2 L. and Y. Y. and , T. T. , 1 1 , D. M. , D. 2 , B. Wu , B. Toxicology, Toxicology, 1 1 SNBL, Seattle, 3 J. C. Tigner C. , J. . 1 2 , A. Keyhani , Biomarker Biomarker 2 1 , Universtiy of. , Universtiy . , A. Keyhani , 1 2 2 Purdue Pharma, , K. Howell 2 , S. Ren 1 Purdue Pharma, Ardsley, Ardsley, Purdue Pharma, 3 1 T. M. Nelson , T. . 1 2 S. M. McPherson K. W. Hew W. K. and D. WU and D. 2 , B. N. Thompson N. , B. 1 , J. Jolette , J. J. C. Tigner C. , J. 1 2 Department of Chemistry, Department of Chemistry, , X. Hao, C. Perraut , X. Hao, C. Perraut C. Roegge 2 Purdue Pharma, Ardsley, NY and Ardsley, Purdue Pharma, Genentech, South San Francisco, CA, Genentech, South San Francisco, 1 C. E. Gavin. Pfizer & Global Research 1 , K. R. Moore . 3 . 2 1 , J. M. Marcek, A. M. Marcek, , J. A. Pettersen B. , X. P. Fang , X. P. and W. E. Trommer E. W. and , D. M. Danilenko , D. , I. Grewal 1 1 2 Toxicology, Charles River Laboratories Charles River Toxicology, 1 2 and K. Robinson Hew W. , K. , L. Ndountse-Tchapda T. R. Gelzleichter T. , H. Ibrahim 2 1 1 1 Biogen Idec, Cambridge, MA and Biogen Toxicology, Charles River Laboratories Preclinical Laboratories Preclinical Charles River Toxicology, Preclinical Montréal, Senneville, QC, Canada. Preclinical Montréal, Senneville, DEVELOPMENT STUDY EMBRYO-FETAL WITH RATS IN SPRAGUE-DAWLEY HYDROCHLORIDE. NALTREXONE Pouliot F. Martin F. Vugmeyster WA. Jacobitz, K. Borg, D. J. Brees, R. B. Nelson, E. Nelson, Brees, R. B. J. D. Jacobitz, K. Borg, and Callegari Development, Novartis Pharma AG, Basel, AG, Pharma Novartis Development, Ehrenfels 2 Switzerland and MICE. Kamenosono Schramm Robinson Tigner QC, Canada. Montréal, Senneville, EMBRYONIC AND EARLY FERTILITY IN SPRAGUE- DEVELOPMENT STUDY WITH NALTREXONE RATS DAWLEY HYDROCHLORIDE. NY and R. Bouchard 2 HISTAMINERGIC H1 BLOCKADE AS A A AS BLOCKADE H1 HISTAMINERGIC THERAPEUTIC SOURCE OF POTENTIAL THE OF EFFECTS ADVERSE OR CLOZAPINE: DRUG ANTIPSYCHOTIC ANTAGONIST THE H1 WITH STUDIES PYRILAMINE. . Department Levin of Psychiatry and and E. D. Medical University Sciences, Duke Behavioral NC. Durham, Center, OF STUDY TOXICITY WEEK ORAL A 13 THE IN HYDROCHLORIDE NALTREXONE 4-WEEK A WITH CYNOMOLGUS MONKEY PERIOD. RECOVERY Development, Groton, CT. Development, EFFECT OF HMG- ANTIOXIDANT STREAM DOWN REDUCTASE COA ON STATIN-INDUCED METABOLITES IN FORMATION OXYGEN REACTIVE MUSCLE CELLS. HUMAN SKELETAL Charles River Laboratories Preclinical Montréal, Laboratories Preclinical Charles River QC, Canada and Senneville, Pouliot Wolf A. University of Kaiserslautern, Kaiserslautern,University Germany. DECOY A BAFF OF SAFETY EVALUATION AND (BR3-Fc) IN MONKEYS RECEPTOR Ardsley, NY. Ardsley, OF THE NONCLINICAL SAFETY PROFILE SYNTHASE OXIDE NITRIC THE NEURONAL SUPPORTED 516, CP-695, (nNOS) INHIBITOR, ACUTE CLINICAL DEVELOPMENT FOR STROKE. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#614 Program Description Description Program #615 #613
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #624 CJC-1134-PC, A LONG-ACTING EXENDIN-4 #633 ORAL AND ESOPHAGEAL PATHOLOGY IN ANALOGUE, IS WELL TOLERATED IN RATS MICE FOLLOWING CHRONIC TREATMENT AND MONKEYS FOR UP TO 7 DAYS. S. Wen, WITH A TRANSFORMING GROWTH T. Najarian, K. Thibaudeau, J. Woo and J. Castaigne. FACTOR–BETA ANTAGONIST. R. Pawliuk1, E. ConjuChem, Inc., Montréal, QC, Canada. Lacasse1, J. Delcarpini1, A. Vitsky1, C. Rogers1, M. McCourt2, J. Powell2, S. Lonning1 and L. Andrews1. #625 RENAL TOLERABILITY OF A 1Genzyme Corporation, Framingham, MA and SECOND-GENERATION ANTISENSE 2Cambridge Antibody Technology, Cambridge, OLIGONUCLEOTIDE (ISIS 113715) IN United Kingdom. MONKEY. T. A. Zanardi1, S. P. Henry1, R. Fey1, M. Johnson2 and P. B. Lappin3. 1ISIS Pharmaceuticals, #634 PRE-CLINICAL DEVELOPMENT OF A Inc., Carlsbad, CA, 2MPI Research, Mattawan, MI MONOCLONAL ANTIBODY TO THE αVβ6 and 3Charles River Laboratories, Sparks, NV. INTEGREN. K. J. Olivier1, M. D. Reed2, A. Gigliotti2, D. Hutto1 and J. B. Clarke1. 1Biogen Idec #626 A NINE-MONTH CHRONIC TOXICITY Inc., Cambridge, MA and 2Lovelace Respiratory STUDY OF CJC-1131, A LONG-ACTING GLP-1 Research Institute, Albequerque, NM. ANALOGUE. Y. Fukushima1, C. N. Papagiannis2, J. Castaigne1 and S. Wen1. 1ConjuChem Inc., Montréal, QC, Canada and 2MPI Research, Inc., Mattawan, Monday, March 6 MI. 1:30 PM to 4:30 PM Exhibit Hall #627 CHARACTERIZING ANIMAL MODELS OF PPAR-G AGONIST INDUCED EDEMA. H. S. POSTER SESSION: RESPIRATORY TRACT INJURY: CELLULAR Younis1, K. Palacio1, B. Simmons2, K. Ogilvie2, J. MECHANISMS Fraser2 and G. J. Stevens1. 1Safety Sciences, Pfizer Inc., San Diego, CA and 2Research Pharmacology, Chairperson(s): Michael Madden, U.S. EPA, Chapel Hill, NC and Adrian Pfizer Inc., San Diego, CA. Nicolescu, Queens University, Kingston, ON, Canada. #628 A TOXICITY STUDY IN RATS TREATED Displayed: 1:30 PM–4:30 PM FOR 1 MONTH WITH LY465608, A PPARα, γ DUAL AGONIST. V. L. Reynolds1, L. I. Boone1, D. Attended: 3:00 PM–4:30 PM 1 1 1 A. Buenger , M. A. Carfagna , K. B. Donnelly , M. #635 ALDEHYDE DEHYDROGENASES 2 1 1 Fitzsimmons , J. M. Sullivan and G. D. Williams . EXPRESSION DURING POSTNATAL 1 Lilly Research Laboratories, Greenfield, IN and DEVELOPMENT: LIVER VS. LUNG. M. Yoon1, MONDAY 2 Covance Laboratories, Madison, WI. M. C. Madden2 and H. A. Barton3. 1NRC Research #629 A TOXICITY STUDY IN BEAGLE DOGS Associateship Program, U.S. EPA, Research Triangle 2 TREATED FOR 1 MONTH WITH LY465608, Park, NC, NHEERL, U.S. EPA, Research Triangle 3 A PPAR ALPHA, GAMMA DUAL AGONIST. Park, NC and NCCT, U.S. EPA, Research Triangle M. A. Carfagna1, L. I. Boone1, D. A. Buenger1, K. Park, NC. 1 2 1 B. Donnelly , M. Fitzsimmons , V. L. Reynolds , J. #636 RECEPTOR-ACTIVATED SMAD AND 1 1 1 M. Sullivan and G. D. Williams . Lilly Research CONNECTIVE TISSUE GROWTH FACTOR 2 Laboratories, Greenfield, IN and Covance Labs, LOCALIZATION IN THE PULMONARY Madison, WI. FIBROSIS. S. Asano, H. Higashiyama, D. #630 THE PPARα AGONIST FENOFIBRATE Yoshimoto, Y. Okamoto, H. Kikkawa and CAUSES INCREASED β-OXIDATION M. Kinoshita. Pharmacology Department, LEADING TO OXIDATIVE INJURY IN GlaxoSmithKline, Tsukuba Research laboratories, SKELETAL AND CARDIAC MUSCLE IN THE Ibaraki, Japan. RAT. J. C. Pettersen, I. Pruimboom-Brees, D. E. #637 EFFECT OF PROSTAGLANDINS ON MRP Amacher, O. L. Francone, S. E. Boldt, R. L. Kerlin EXPRESSION IN PRIMARY HUMAN LUNG and W. E. Ballinger. Pfizer Global Research & CELLS. H. Foth, A. Raemisch, A. W. Torky and E. Development, Groton, CT. Stehfest. Environmental Toxicology, University of #631 SAFETY ASSESSMENT OF 11B- Halle, Halle / Saale, Germany. HYDROXYSTEROID DEHYDROGENASE #638 ROLE OF CFTR IN THE LUNG’S TYPE 1 KNOCKDOWN USING ANTISENCE GLUTATHIONE ADAPTIVE RESPONSE TO OLIGONUCLEOTIDES IN MICE. K. A. Palacio, CIGARETTE SMOKE AND INHIBITION T. McDermott, B. Jessen, G. J. Stevens and H. WITH MYCOPLASMA PNEUMONIAE Younis. Safety Sciences, Pfizer, San Diego, CA. INFECTION. C. T. Kariya1, B. J. Day1, 2, R. Martin2 2 1 #632 LIPOIC ACID INHIBITS SUPEROXIDE and H. Chu . Toxicology, UCHSC, Denver, CO and 2 RELEASE IN HUMAN NEUTROPHILS. H. Medicine, NJMRC, Denver, CO. 1 2, 1 1 C. O’Neill and C. W. White . Department of #639 ZINC INDUCES TRANSCRIPTIONAL Pharmaceutical Sciences, Program in Toxicology, ACTIVITY THROUGH A NON-CANONICAL 2 UCHSC, Denver, CO and Department of Pediatrics, NF-κB ACTIVATION PATHWAY. D. Cao2, Y. National Jewish Medical Research Center, Denver, Kim1, W. Reed1, W. Wu1, I. Jaspers1, R. Silbajoris2 CO. and J. M. Samet2. 1UNC, Chapel Hill, NC and 2HSD, NHEERL, U.S. EPA, Chapel Hill, NC. up-to-date information at www.toxicology.org 107 , 2 . 2 , 2 M. C. , 1 , D. Salvail , D.
1 Toxicology, Toxicology, Safety 1 1 . Toxicology, Toxicology, . 2 1 and S. Groom . , J. Bultman , J. 1, 2 1 2 1, 2 , S. Mason 1 Annual Meeting Annual IPS Therapeutique Therapeutique IPS Therapeutique IPS 2 2 th , D. Patel , D. 1 , N. Caya , N. and D. Salvail and D. and J. Layer and J. 1, 2 2 1 SOT's 45 SOT's and R. D. Sarazan and R. D. 1, 2 C. Banks , 1 J. S. Lafferty J. , D. Guergues , D. . 1 Toxicology, Covance Laboratories, Madison, Covance Toxicology, 2 Genome Explorations, Memphis, TN and Genome Explorations, Memphis, Laboratories Preclinical Charles River Toxicology, CARDIOVASCULAR AND RESPIRATORY AND RESPIRATORY CARDIOVASCULAR TELEMETERIZED IN STUDY VALIDATION AND BEAGLE CYNOMOLGUS MONKEYS Pharmacology, Covance Laboratories, Madison, WI Laboratories, Madison, Covance Pharmacology, Montréal, Senneville, QC, Canada. Sponsor: Montréal, Senneville, J. K. Herman J. Laboratories Preclinical Montréal, Charles River QC, Canada and Senneville, and J. Valentin. Safety Pharmacology, Safety Pharmacology, Valentin. Hammond and J. Macclesfield, R&D, AstraZeneca Assessment, Safety United Kingdom. DOGS. and WI. CARDIOVASCULAR AN INTEGRATED ASSESSMENT FOR SAFETY RISK AND IN- IN-VIVO PHARMACOLOGY: AND EFFECTS OF DL-SOTATOL VITRO HALOPERIDOL. K. Norton Banks S. Mason EVALUATION OF TWO MOUSE STRAINS TWO OF EVALUATION MODEL SYSTEMS FOR AS POTENTIAL PULMONARY OBSTRUCTIVE CHRONIC OF UTILIZATION DISEASE (COPD): GENE EXPRESSION MICROARRAY R. Rooney ANALYSIS. 1 2 Charles River Laboratories Preclinical Montréal, Laboratories Preclinical Charles River QC, Canada and Senneville, Vezina Inc., Sherbrooke, QC, Canada. QC, Inc., Sherbrooke, QT-SCREEN TIME-EFFECTIVE AND A COST- MEASUREMENTS COMBINES IN-VIVO HERG WITH IN-VITRO IN GUINEA-PIGS Hebert N. CURRENT INHIBITION. QC, Canada. Inc., Sherbrooke, A NON-INVASIVE OF OPTIMATISON SYSTEM FOR TELEMETRY ASSESSMENT IN ELECTROCARDIOGRAM McMahon, N. A 3-YEARS REVIEW. DOGS: Simpson, T. Hamre, D. D. Schofield, H. Prior, J.
1:30 PM–4:30 PM 1:30 PM–3:00 PM (Continued) Annual Annual th #649 Attended: #650 #648 1:30 PM to 4:30 PM Exhibit Hall AND ECG SYSTEM: CARDIOVASCULAR POSTER SESSION: HERG Ashok OH and Inc., Cleveland, ChanTest, Brown, Authur Chairperson(s): Princeton, NJ. Squibb Company, Gupta, Bristol-Myers Displayed: Monday, March 6 March Monday, #651 #652 45 108 . Meeting & ToxExpo & Meeting ,
1 and W. J. J. , W. W. W. , L. M. 1 Y. and Y. 2 UNC, Chapel 1 W. and W. 1 . 2 Department J. F. Brien F. , J. 2 Microbiology, Boston Boston Microbiology, , A. M. Soucy, V. , N. 2 , P. Stone , P. 1 , P. A. Bromberg , P. . CIIT Centers for Health 1 W. M. Pierce , W. 2 and J. M. Samet and J. A. C. Nicolescu 1
, W. Wu W. , J. Cai , J. 1 , P. Toselli , P. 2 2 E. S. Roberts
HSD, NHEERL, U.S. EPA, Chapel EPA, U.S. NHEERL, HSD, 2 Department of Medicine, University Department of Medicine, University W. J. Racz J. W. Brien, F. A. C. Nicolescu, J. 1 I. Chou , W. Reed W. , , I. Jaspers . , 1 1 1 F. W. Benz W. , F. 1, 2 -INDUCED IL-8 EXPRESSION -INDUCED IL-8 EXPRESSION 1 . Pharmacology & Toxicology, Toxicology, & . Pharmacology E. Massey and T. Biochemistry, Boston University School of Boston University Biochemistry, 1 2+ . 1 NHEERL/HSD/CRB, U.S. EPA, Research Triangle Triangle Research EPA, U.S. NHEERL/HSD/CRB, NC. Park, CA. D. C. Dorman Bonner and D. NORMAL GENE EXPRESSION IN MALE RAT AND FEMALE SPRAGUE-DAWLEY AND OLFACTORY RESPIRATORY NASAL EPITHELIA. Racz Canada. Kingston, ON, University, Queen’s OF PM- ANALYSIS MICROARRAY INDUCED GENE EXPRESSION IN HUMAN T. EPITHELIAL CELLS. M. BRONCHIAL Devlin and R. B. Graff W. D. A. Dailey, Schmitt, L. ; INVESTIGATION ; INVESTIGATION VITRO LUNG CELLS IN L. J. BY NITRONES. OF CYTOPROTECTION Comeau, Kang of Louisville, Louisville, KY and S. Gao Li Medicine, Boston, MA and ZN Hill, NC and Hill, NC. THE BY COPPER OF REGULATION AND OXIDASE EXPRESSION OF LYSYL IN CADMIUM-RESISTANT COLLAGEN Zhao Y. LUNG FIBROBLASTS. FETAL RAT Research, Research Triangle Park, NC. Park, Triangle Research, Research THE MOUSE IN PROTEOMICS AIRWAY TWO OF A COMPARISON LUNG: TO ABILITY THEIR AND APPROACHES AIRWAY DETECT SEX DIFFERENCES IN and A. Isbell M. K. M. Sutherland, PROTEINS. Davis, VM:APC/CHE, UC Davis, . Winkle Van L. S. . Pharmacology & Toxicology, Queen’s Queen’s Toxicology, & . Pharmacology E. Massey T. Canada. Kingston, ON, University, IN FREE RADICAL PRODUCTION TO EXPOSED MITOCHONDRIA AMIODARONE. Y. Kim Y. Feng University School of Medicine, Boston, MA. School of Medicine, Boston, University ARE DISULFIDES METALLOTHIONEIN PRESENT IN METALLOTHIONEIN- TRANSGENIC OVEREXPRESSING INCREASE UNDER AND MOUSE HEART STRESS. CONDITIONS OF OXIDATIVE of Pharmacology and Toxicology, University of University Toxicology, and of Pharmacology Louisville, Louisville, KY. AND AMIODARONE OF TOXICITY IN HUMAN DESETHYLAMIODARONE Graves INVOLVES AP-1, ERK, AND JNK ACTIVITIES ACTIVITIES AND JNK ERK, AP-1, INVOLVES EPITHELIAL CELLS. AIRWAY IN HUMAN 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#644 Program Description Description Program #642 #643
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #653 CARDIOVASCULAR ASSESSMENT #661 A COMPARISON OF HEART RATE AND OF BICIFADINE HCL IN CONSCIOUS, ECG DATA COLLECTED USING THE RADIOTELEMTRY-IMPLANTED VIVOMETRICS LIFESHIRTâ AND A CYNOMOLGUS MONKEYS. M. V. Soloviev1, STANDARD DSI TELEMETRY DEVICE. H. J. P. Tizzano4, L. Freshwater2 and J. Buelke-Sam3. Penton1, S. Mason1, K. Norton1, C. Banks1 and 1WIL Research Laboratories, LLC, Ashland, OH, A. Derchak2. 1Toxicology, Charles River Labs, 2BioSTAT Consultants, Portage, MI, 3Toxicology Senneville, QC, Canada and 2VivoMetrics, Ventura, Services, Greenfield, IN and 4DOV Pharmaceutical, CA. Inc., Hackensack, NJ. Sponsor: C. Chengelis. #662 INTEGRATED NONCLINICAL #654 RELATIONSHIP AMONG DRUG-INDUCED CARDIOVASCULAR SAFETY EVALUATION PROLONGATION OF CORRECTED QT, OF OF A MIXED ION CHANNEL INHIBITOR. R. CORRECTED JT, AND DURATION FROM Peri, A. K. Gupta, S. R. Arthur, S. V. Mandlekar, G. PEAK TO END OF T-WAVE IN A TELEMETRY Cornelius, J. Zhu, E. Burnett, L. Sun, D. Li, P. C. GUINEA PIG MODEL. M. Shiotani, T. Harada, Levesque, B. D. Car and B. Gemzik. Bristol-Myers J. Abe, Y. Hamada and I. Horii. Worldwide Safety Squibb, Princeton, NJ. Sciences, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Inc., Aichi, Japan. #663 CARDIAC ION CHANNEL APPLICATIONS Sponsor: M. Kurata. OF PATCHXPRESS® AUTOMATED ELECTROPHYSIOLOGY. Y. A. Kuryshev1, J. #655 TORSADOGENIC DRUGS INCREASE Brimecombe1, G. E. Kirsch1 and A. M. Brown1, ELECTRICAL ALTERNANS MEASURED 2. 1ChanTest Inc., Cleveland, OH and 2Physiology IN LANGENDORFF PERFUSED RABBIT & Biophysics, Case Western Reserve University, HEARTS. J. Kramer1, A. Brown1, 2, G. Kirsch1 Cleveland, OH. and T. Yang1. 1ChanTest Inc., Cleveland, OH and 2Physiology & Biophysics, Case Western Reserve #664 SAFETY PHARMACOLOGY: IN VITRO University, Cleveland, OH. AND EX VIVO EFFECTS OF URIDINE TRIPHOSPHATE ON CARDIAC #656 COMPARISON OF COMMON METHODS ELECTROPHYSIOLOGY AND FOR QT INTERVAL DATA CORRECTION AT HEMODYNAMICS. D. Salvail2, M. R. Gralinski1, HIGH HEART RATES. J. R. May, M. P. Benson, T. E. Tanhehco1 and G. Page2. 1Cordynamics J. Baird and P. E. Newton. MPI Research, Mattawan, Inc., Chicago, IL and 2IPS Therapeutique Inc., MI. Sherbrooke, QC, Canada. MONDAY #657 EFFECTS OF INHALATION DOSING #665 EFFECTS OF BICIFADINE HCL ON PROCEDURES ON BASELINE CLONED HERG CHANNELS EXPRESSED CARDIOVASCULAR PARAMETERS IN MAMMALIAN CELLS. J. Brimecombe3, AND RESPONSE TO D, L-SOTALOL IN G. E. Kirsch3, H. Erickson3, G. J. Schaefer1 and CONSCIOUS TELEMETERED DOGS. K. G. J. P. Tizzano2. 1WIL Research Laboratories, Meecham, D. J. Beard, S. A. Moore, P. H. Davies LLC, Ashland, OH, 2DOV Pharmaceutical, Inc., and C. J. Hardy. Huntingdon Life Sciences Ltd., Hackensack, NJ and 3ChanTest, Inc., Cleveland, OH. Huntingdon, United Kingdom. #666 INHIBITION OF HERG TRAFFICKING #658 EFFECTS OF VERAPAMIL AND SOTALOL BY CARDIAC GLYCOSIDES. B. Wible1, Y. ON ECG INTERVALS IN THE CONSCIOUS Kuryshev1, P. Hawryluk1 and A. M. Brown1, 2. TELEMETERED MINIPIG. D. J. Beard, P. 1ChanTest Inc., Cleveland, OH and 2Physiology H. Davies, K. G. Meecham and C. J. Hardy. & Biophysics, Case Western Reserve University, Huntingdon Life Sciences Ltd., Huntingdon, United Cleveland, OH. Kingdom. #667 INHIBITORY EFFECTS OF PDE INHIBITORS #659 ALFUZOSIN TESTS POSITIVE IN ON HERG CURRENTS; DOES PKA NONCLINICAL ASSAYS. A. E. Lacerda1, Y. A. REGULATE HERG CHANNEL ACTIVITY? K. Kuryshev1, M. Renganathan1, H. Eng1, L. Dewey1, S. Yunomae, S. Ichisaki, J. Matsuo, M. Haruyama, S. J. Danthi1, J. W. Kramer1, T. Yang1 and A. M. Brown1, Nagayama, T. Susumu, K. Fukuzaki, R. Nagata and 2. 1ChanTest Inc., Cleveland, OH and 2Physiology G. Kito. SNBL DSR, Kagoshima, Japan. & Biophysics, Case Western Reserve University, Cleveland, OH. #660 RESPIRATORY SAFETY PHARMACOLOGY STUDIES USING SNOUT-ONLY PLETHYSMOGRAPHS AND TELEMETRY FOR RECORDING INTRAPLEURAL PRESSURE DURING IN CONSCIOUS CD RATS: A VALIDATION STUDY USING AN AEROSOL OF METHACHOLINE. R. M. Huckle, G. A. Graham, K. G. Meecham and C. J. Hardy. Huntingdon Life Sciences Ltd., Huntingdon, United Kingdom. up-to-date information at www.toxicology.org 109 ,
1 1, E. A. , T. T. , H. , 1 . . 1 , S. and A. and and 2 3 , E. Han . . Safety 1 1 T. Oyama T. , T. Yamaguchi T. , 1 , E. Lee 3 , S. I. Hoehle 1 Food Chemistry and Food S. A. Meyer and S. Annual Meeting Annual S. J. Schomaker S. J. 1 W. G. Kirlin G. , W. College of Pharmacy, of Pharmacy, College . 1 th 3 J. V. Bruckner V. and J. 1 T. Jeong , T. Chemistry, Spelman College, Spelman College, Chemistry, , A. Riess , 1 1 1, 2 T. Kawamoto and T. . 2 , T. Murakami T. , 2 1 V. M. Kale V. Pharmacology/Toxicology, Pharmacology/Toxicology, 2 SOT's 45 SOT's M. Metzler Pharmacology and Toxicology, Toxicology, and Pharmacology College of Pharmacy, Research Center Research Pharmacy, of College 2 . Vet. Med.: Vet. . Fanucchi V. and M. 2 , K. M. Jackson 1 and 2 , Y. Hwang Y. , Pharmacy, Chosun University, Kwangju, Kwangju, Chosun University, Pharmacy, 1 , S. G. Walch , S. G. . 1, 2 , M. Ogawa , L. M. Davison, B. N. DeLong, N. B. K. C. Day, L. M. Davison, 1 1 N. Kunugita , N.
1 1, 2 Department of Health Information Science, School , K. Oh Department of Environmental Health, School Department of Environmental Kinaga for Proteineous Materials, Chosun University, for Proteineous Materials, Chosun University, and South Korea Kwangju, D. E. Amacher E. and D. E. Boldt, M. Mirsky Anatomy, Physiology and Cell Biology, University University and Cell Biology, Physiology Anatomy, CA. Davis, of California, Davis, AMONG THE RELATIONSHIP ENZYME INDUCTION, MICROSOMAL AND HISTOLOGICAL WEIGHT, LIVER of Health Science, University of Occupational and of Occupational of Health Science, University Japan. Health, Kitakyushu, Environmental of Medecine, University of Occupational and of Occupational of Medecine, University Japan and Health, Kitakyushu, Environmental Toxicology, University of Louisiana-Monroe, University Toxicology, Monroe, LA. 2 COMPETITIVE INHIBITION OF CYP 1A1 CATECHIN BY 3-O-ACETYLATED ACTIVITY Kim D. MICROSOME. IN HEPATIC 2 CHANGE IN CYNOMOLGUS MONKEY STUDIES. TOXICOLOGY Anand S. Muralidhara, S. S. PROLIFERATION OF HUMAN CACO-2 HUMAN CACO-2 OF PROLIFERATION BY N-ACETYLATION CELLS MEDIATED OF 3-AMINO- REACTIONS AND OXIDATION (AHBA). 4-HYDROXYBENZENEARSONATE M. Rollins-Hairston Atlanta, GA and M. Solyom PHASE I ENZYMES EXPRESSED IN NON- SMALL CELL LUNG CANCER. Isse T. 1 Morehouse School of Medicine, Atlanta, GA. Morehouse School of Medicine, INHIBITS CURCUMIN GLUCURONIDE ASSEMBLY. CELL-FREE MICROTUBULE Pfeiffer Toxicology, University of Karlsruhe, Karlsruhe, University Toxicology, and Germany Korea, South Plopper C. G. Sciences Groton, Pfizer Inc., Groton, CT. TRICHLOROETHYLENE OF ONTOGENY IN IMMATURE (TCE) METABOLISM McPhail, B. (S-D) RATS. SPRAGUE-DAWLEY G. S. Bayse S. G. Toxicology, University of Georgia, Athens, GA. of Georgia, University Toxicology, OF OF CYP3A METABOLISM ROLE HERBICIDES CHLOROACETANILIDE RAT OF ISOLATED IN CYTOTOXICITY HEPATOCYTES. University of Arizona, Tucson, AZ. Tucson, Arizona, of University Yeungnam University, Kyungsan, South Korea. Kyungsan, University, Yeungnam CYP3A1 IN 1- OF PULMONARY ROLE ACUTE INDUCED NITRONAPHTHALENE ADULT AND IN POSTNATAL LUNG INJURY RATS. Jeong
(Continued) Annual Annual th #679 #677 #674 #675 #680 #681 #676 #678 45 110 , 1 Meeting & ToxExpo & Meeting , 3 and , A. , 1 T. and T. 1
Institute S. K. , S. Sorokina 2 1 , N. Currier, N. 1 . R. F. and R. F. 1 , E. Lee Medicine, Boston GeneGo Inc., St 2 3 1 . Korea Institute of Korea 1 2 Pathology, Boston Pathology, 1 , S. Andreyev , S. , S. Oh . 2 1, 2 2, 1 , Y. Kim Y. , 1 S. E. Solomon
, E. Rakhmatulin 1 S. Ekins School of Pharmacy, Department of School of Pharmacy, 2 , T. Jeon T. , 1 D. Sherr and D. and T. Nikolskaya T. and 1 3, 1 College of Pharmacy, Chungnam National Chungnam of Pharmacy, College College of Pharmacy, Yeungnam University, University, Yeungnam of Pharmacy, College , E. Kirillov 1 1 1 S. Lee . . 2 1 , M. A. Abdelmegeed A. , M. 1 Environmental Health, Boston University School of Health, Boston University Environmental A COMBINED QUANTITATIVE A COMBINED QUANTITATIVE RELATIONSHIP ACTIVITY STRUCTURE APPROACH AND SYSTEMS BIOLOGY TOXICITY AND METABOLISM DRUG TO ASSESSMENT. A. Bugrim Jeong TRANSFERASES OF COHO SALMON H. Trute, (ONCORHYNCHUS KISUTCH). M. . Department Janssen and E. Gallagher of P. LaVire, and Occupational Health Sciences, Environmental WA. Seattle, Washington, of University MICE. University School of Medicine, Boston, MA, School of Medicine, Boston, University Health, Boston, MA and Public Kim INSECTICIDE SYNERGISTS? S. Ramasamy TUMORS IN MICE. 2 State Wayne Health Sciences, of Environmental Detroit, MI. University, CONJUGATION OF GLUTATHIONE ROLE AND THE HEPATOTOXICITY IN INDUCED BY 1- IMMUNOTOXICITY IN FEMALE BALB/C BROMOPROPANE Joseph, MI and of Maryland, Pharmaceutical Sciences, University Sponsor: C. Giroux Baltimore, MD. COULD EMERGING GENOMIC ASSIST IN UNDERSTANDING TOOLS OF ACTION THE MECHANISMS OF University School of Medicine, Boston, MA. School of Medicine, Boston, University IN REGULATION INSULIN SIGNALING S- ALPHA-CLASS GLUTATHIONE OF TRANSFERASE EXPRESSION IN PRIMARY HEPATOCYTES. RAT CULTURED . OPPTS, U.S. EPA, Arlington, VA. Arlington, EPA, Doherty. OPPTS, U.S. J. PATHWAYS ONCOGENIC SIGNALING MAMMARY DMBA-INDUCED IN ACTIVATED University, Deajeon, South Korea and Deajeon, South Korea University, Ryabov Toxicology, Daejon, South Korea. Toxicology, OF HEPATIC CHARACTERIZATION S- GLUTATHIONE AND OLFACTORY Gyeongsan, South Korea and South Korea Gyeongsan, D. Seldin D. Novak
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#669 #668 #672 Attended: : Sharon Meyer, University of Louisiana, Monroe, LA. of Louisiana, Monroe, University Meyer, Chairperson(s): Sharon Displayed: Exhibit Hall AND TOXICITY METABOLISM POSTER SESSION: POLYMORPHISMS Monday, March 6 March Monday, 1:30 PM to 4:30 PM #671
#670 Program Description Description Program #673
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #682 METABOLITES OF TRYPTANTHRIN BY RAT #691 METABOLISM OF ETHNAOL IN LIVER MICROSOMES. G. Kim, S. Lee, T. Jeon, ADH-DEFICENT HEPG2 CELLS AND C. Jin, I. Jun, D. Lee, Y. Jahng and T. Jeong. College ADH-OVEREXPRESSED VA-13 CELLS: of Pharmacy, Yeungnam University, Gyeongsan, SINGIFICANCE OF NONOXIDAITVE South Korea. METABOLISM IN ETHANOL-INDUCED TOXICITY. B. S. Kaphalia. Pathology, University #683 CHARACTERIZATION OF HUMAN LIVER of Texas Medical Branch, Galveston, TX. CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF RUTAECARPINE. #692 NONOXIDATIVE METABOLISM OF T. Jeong1, D. Lee1, S. Lee1, D. Kim2, E. Lee1 and Y. ETHANOL TO FATTY ACID ETHYL ESTERS Jahng1. 1College of Pharmacy, Yeungnam University, AND THEIR CYTOTOXICITY IN AR42J Gyeongsan, South Korea and 2Bioanalysis and CELLS. H. Wu1, G. A. Ansari1 and B. S. Kaphalia1. Biotransformation Research Center, KIST, Seoul, 1Pathology, University of Texas Medical Branch, South Korea. Galveston, TX, 2Pathology, University of Texas Medical Branch, Galveston, TX and 3Pathology, #684 DETERMINATION OF ANTHRICIN AND University of Texas Medical Branch, Galveston, TX. ITS METABOLITES IN VITRO BY LIQUID CHROMATOGRAPHY/ELECTROSPRAY #693 ALDEHYDE DEHYDOROGENASE 2 IONIZATION-TANDEM MASS METABOLIZES PROPIONALDEHYDE. SPECTROMETRY. I. Jun, S. Lee, T. Jeon, G. - IN VITRO ANALYSIS WITH LIVER Kim, D. Lee, C. Jin, S. Lee and T. Jeong. College of SUBCELLULAR FRACTION DERIVED FROM Pharmacy, Yeungnam University, Gyeongsan, South ALDH2 KNOCKOUT MOUSE. -. T. Yamaguchi1, Korea. T. Oyama1, T. Isse1, M. Ogawa1, T. Murakami1, T. Kinaga1, K. Kitagawa2, I. Uchiyama3 and T. #685 IN VITRO METABOLISM OF Kawamoto1. 1Environmental Health, University ETHYLBENZENE BY RAT, MOUSE AND of Occupational and Environmental Health, HUMAN LIVER AND LUNG MICROSOMES. Kitakyushu, Fukuoka, Japan, 2First Department S. A. Saghir, D. L. Rick, M. J. Bartels and J. S. Bus. of Biochemistry, Hamamatsu Medical University, The Dow Chemical Company, Midland, MI. Hamamatsu, Shizuoka, Japan and 3Environmental #686 HUMAN CYP 450 ISOFORM SPECIFIC hygiene, Kyoto University, Kyoto, Japan. METABOLISM OF POLYCHLORINATED #694 CHARACTERIZATION OF TWO RAT BIPHENYL IUPAC #101. J. E. McGraw and D. P. CARBOXYLESTERASES INVOLVED IN
Waller. Biopharmaceutical Sciences, University of PYRETHROID METABOLISM. M. K. Ross, S. MONDAY IL at Chicago College of Pharmacy, Chicago, IL. E. Lentz and A. Borazjani. Center for Environmental #687 HEPATIC P450 ENZYMES PLAY A Health Sciences, Mississippi State University, DOMINANT ROLE IN THE DISPOSITION OF Mississippi State, MS. 7, 12-DIMETHYLBENZ[A]ANTHRACENE- #695 THE EFFECT OF DIELDRIN EXPOSURE TRANS-3, 4-DIHYDRODIOL IN MICE. J. Gu, ON SEVERAL ENZYMES RESPONSIBLE H. Cui, W. Yang and X. Ding. Wadsworth Center, FOR THE METABOLISM OF Albany, NY. ORGANOPHOSPHORUS INSECTICIDES. 1 2 1 #688 ROLE OF THIOACETAMIDE-SULFOXIDE J. A. Crow , H. W. Chambers , E. C. Meek and J. 1 1 METABOLISM IN SATURATION KINETICS E. Chambers . Center for Environmental Health OF THIOACETAMIDE. J. Chilakapati1, M. C. Sciences, Mississippi State University, Mississippi 2 Korrapati1, R. A. Hill2 and H. M. Mehendale1. State, MS and Department of Entomology, 1Toxicology, ULM, Monroe, LA and 2Basic Mississippi State University, Mississippi State, MS. Pharmaceutical Sciences, ULM, Monroe, LA. #696 A SPECTROSCOPIC STUDY OF THE #689 COMPARISON OF HALO- AND INTERACTION OF 1, 3-DINITROBENZENE NITROBENZENE TOXICITY IN RAT AND WITH NEURONAL NITRIC OXIDE HUMAN HEPATOCYTES. N. Jensen2, K. Chan1, SYNTHASE AND ITS ISOLATED HEME 1 2 1 P. Silber2 and P. O’Brien1. 1Pharmaceutical Sciences, DOMAIN. J. Tobias and R. T. Miller . Toxicology, University of Toronto, Toronto, ON, Canada and 2In University of Kentucky, Lexington, KY and 2 Vitro Technologies Inc., Baltimore, MD. Biological Sciences, University of Texas at El Paso, El Paso, TX. #690 TRANSESTERIFICATION OF METHYLPARABEN BY RAT GASTROINTESTINAL SEGMENTS. M. Lakeram1, D. J. Lockley2, R. Pendlington2 and B. Forbes1. 1King’s College London, Pharmaceutical Science Research Division, London, United Kingdom and 2Safety and Environmental Assurance Centre, Unilever Colworth, Bedfordshire, United Kingdom. Sponsor: D. Basketter.
up-to-date information at www.toxicology.org 111 - - - . 2 , O. , O. 2 . .
and M. Resnick 1 , D. Menendez , D. 1 Annual Meeting Annual th R. Stahlmann Chromosome Stability J. Zheng and J. 2 Laboratory of Experimental 3 , B. Krysiak , B. W. Yuan , W. 1, 3 SOT's 45 SOT's G. Schoenfelder
J. Chung J. , A. Inga , 1 Institute of Clinical Pharmacology and Toxicology, Toxicology, and Institute of Clinical Pharmacology Krysiak A SINGLE NUCLEOTIDE PROMOTER PROMOTER A SINGLE NUCLEOTIDE THE (SNP) PLACES POLYMORPHISM THE P53 IN FLT-1 VEGF-RECEPTOR HUMAN TRANSCRIPTIONAL STRESS-RESPONSE NETWORK. Charite, Berlin, Germany, 1 Cancer Research Institute, National B, Oncology Sponsor: Genoa, Italy. IST, CELLS. Boston, MA. METABOLISM AND TOXICITY OF TOXICITY AND METABOLISM STYRENE AND HALOGENATED STYRENE TRANSGENIC IN CYP2E1 DERIVATIVES Pharmaceutical Sciences, Northeastern University, Section, Laboratory Genetics, Institute of Molecular Health Sciences, NIH, Research of Environmental NC and Park, Triangle
(Continued) Annual Annual th Inhalation SS* Risk Assessment SS Risk The U.S. Environmental Protection Agency is currently reassessing existing existing reassessing currently is Agency Protection Environmental U.S. The and new science that underlies scientificcurrent literaturePM andfrom ozoneair qualityregulation.the existence to of The toxic epidemiologicalentities in the studiesambient and suggestpotential adverse health effects associated with their exposure. Animal toxicology studies have yet to provide convincing dose-appropriate evidence to humansupport thehealth adverse effects reported inmolecular epidemiologicalmechanisms studies.indicating The the lackeffects biological ofand plausibilityuncertainties associatedfor healthwith necessitateepidemiological investigationsthe need for developingscientists from an various disciplines integratedin a larger researchmore comprehensive forum strategyto define by health outcomes and risks. The present outside symposiumthe box’ is forum a to ‘think facilitate innovative global perspectives pollution on from air bench to public health outcomes inclusive of risk assess #703 4:30 PM to 6:00 PM Room 7A AIR THE COMPLEXITIES OF SESSION: ROUNDTABLE AN INTEGRATED THE NEED FOR POLLUTION REGULATION: PERSPECTIVE AND REGULATORY RESEARCH Park, Triangle Research EPA, U.S. Chairperson(s): Srikanth S. Nadadur, NC. Park, Triangle Research EPA, NC and Daniel Costa, U.S. by: Endorsed Monday, March 6 March Monday, ment and regulation. The panel will understandingdiscuss currentthe complexitiesresearch effortsof in‘One pollution atmosphere’ andapproaches the to impactsair on The regulation. issues discussed publicwill include (1) the healthstate of the art efforts and the scientificfor a comprehensive qualitative basisand quantitative analysis of of the air sheds across U.S.; (2) determination of air quality based on sources of emission characteristics and reduction in source; (3) air quality assessments; (4) and potential health toxic constituents effects in the ambient as determined by animal studies toxicology and; (5) analyses utilized integrative in devel oping criteria for regulation of PM from the ‘one The atmosphere’ approach. objective is open approaches andto address public freehealth concerns regarding air discussionquality regula and efficiently. of tion effectively current and alternative #704 45 112 Meeting & ToxExpo & Meeting , , 1 1 J. , J. and . 2 and 2 2 N. M. N. , A. E. , 1 Medical M.
2 Division of Division 1 , S. Ishida C. E. Hill . 3 Department
1 2 , H. Abadin , H. 1 , J. O’Kane , J. 1 , S. Suzen , D. Dannappel , D. and S. Burgaz 1 2 4 , S. Kim 2 CDC/ATSDR, Atlanta, CDC/ATSDR, 1 . D. Moffett , D. 1 and Y. Ohno Y. and 1 4 K. Golka K. S. Squibb , , A. O. Ada A. O. , , 3 2 1 , Y. Alemdar Y. , , A. Yawata A. , 4 1 . Department of Gastrointestinal 3 Department of Hygienic Chemistry, Department of Hygienic Chemistry, 2 , J. Sawada , J. , E. Murray Toxicology, University of Maryland University Toxicology, 1 1 Pharmacology, Luis Razetti Medical Pharmacology, 1 Clinical Occupational Medicine, Institut 1 2 . B. Fowler and B. , S. Efe . 2 2 , G. Banfi 3 3 M. Ema Epidemiology Consultant, Atlanta, GA. Consultant, Epidemiology 2 1, 2 , S. Ozawa , J. L. Powell , J. 1 1 , M. Yilmazer , M. 1 Eregli Iron and Steel Works Co., Karadeniz Works Iron and Steel Eregli 4 Project Team for Pharmacogenetics, National for Pharmacogenetics, Team Project of Biochemistry and Immunochemistry, Division Department of Urology, Semmelweiss University, University, Semmelweiss Department of Urology, Department of Toxicology, Ankara University, Ankara University, Toxicology, Department of RELATIONSHIP OF ALCOHOL OF RELATIONSHIP IN FETAL GENOTYPE 2 DEHYDROGENASE DISORDERS. ALCOHOL SPECTRUM School, Universidad Central de Venezuela, Caracas, Venezuela, Central de School, Universidad Venezuela, Pharmacology, National Institute of Health Sciences, Pharmacology, Japan, Tokyo, and Research Technology, University of Maryland University Technology, and Research School of Medicine, Baltimore, MD. THE IN EFFECT OF POLYMORPHISMS GENE MUTATION MGMT GENE ON HPRT AND ON MGMT PROTEIN FREQUENCY A NOVEL AS MEASURED BY ACTIVITY ASSAY. FLUORESCENCE-BASED 4 Sponsor: M. Sunouchi 3 Japan and Tokyo, Institute of Health Sciences, Japan. Tokyo, National Institute of Health Sciences, . Preventive Medicine and Abdel-Rahman. Preventive and S. Z. Medical Texas of Community Health, University TX. Branch, Galveston, AND GENE EXPRESSION POLYMORPHISM AND SYNTHASE THYMIDYLATE OF DEHYDROGENASE DIHYDROPYRIMIDINE TO THE PREDICTION OF SENSITIVITY IN A. Miyajima- DRUGS. FLUOROPYRIMIDINE Tabata J. D. Cook D. J. School of Medicine, Baltimore, MD and Scinicariello GA and I. Romics 3 Budapest, Hungary. WHERE ALAD POLYMORPHISM: AND LEAD F. A META-ANALYSIS. DOES IT LEAD? and Dortmund University, Arbeitsphysiologie, fuer and Germany Westfalia, Nord Rhein Dortmund, EFFECTS OF CYP AND GST GENETIC AND GST GENETIC EFFECTS OF CYP THE URINARY ON POLYMORPHISMS IN LEVELS OF 1-HYDROXYPYRENE WORKERS. TURKISH COKE OVEN Iscan Demirbag 1 Turkey, Ankara, of Pharmacy, Faculty M. Sexton Spiegl , C. S. Hallberg , C. S. Hallberg Wolfe K. J. Kinslow, , C. J. Wickliffe K. of Toxicology, Gazi University, Faculty of Pharmacy, of Pharmacy, Faculty Gazi University, Toxicology, of Turkey, Ankara, Eregli, Turkey. Eregli, 2 GENOTYPE N-ACETYLTRANSFERASE A. M. IN BLADDER CANCER PATIENTS. Greaves Showa Pharmaceutical University, Machida, Japan, Pharmaceutical University, Showa Department, Yuksek Ihtisas Hospital, Ankara, Turkey Turkey Ankara, Hospital, Ihtisas Yuksek Department, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#700 #701 #702 #699
#697 Program Description Description Program #698
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #705 4:30 THE COMPLEXITIES OF AIR POLLUTION #711 4:30 DISTANCE LEARNING IN TOXICOLOGY: REGULATION: THE NEED FOR EFFECTIVE TEACHING THROUGH AN INTEGRATED RESEARCH AND TECHNOLOGY. J. Huggins1, J. Duffus3, J. Morris2 REGULATORY PERSPECTIVE. S. S. Nadadur1 and K. Willett4. 1Bioscience and Biotechnology, and D. L. Costa2. 1Environmental Media Assessment, Drexel University, Philadelphia, PA, 2Information U.S. EPA, Research Triangle Park, NC and 2ORD, Resources and Technology, Drexel University, U.S. EPA, Research Triangle Park, NC. Philadelphia, PA, 3The Edinburgh Centre for Toxicology, Edinburgh, Scotland, United Kingdom #706 4:36 PM COMPOSITION, SOURCES, AND THEIR and 4School of Pharmacy, The University of HEALTH EFFECTS. P. K. Hopke. Center for Mississipppi, University, MS. Air Resources Engineering and Science, Clarkson University, Potsdam, NY. Sponsor: S. Nadadur. #712 4:40 ASYNCHRONOUS TEACHING AND LEARNING. J. Morris. Information Resources and #707 4:46 LINKING HEALTH EFFECTS TO SOURCES Technology, Drexel University, Philadelphia, PA. OF PARTICULATE MATTER: IMPACTS OF Sponsor: J. Huggins. SOURCE OPERATION AND DESIGN ON PARTICLE ATTRIBUTES. A. Miller and W. P. #713 4:56 RISK AND BENEFIT ANALYSIS OF AN Linak. Office of Research and Development, U.S. ONLINE UNDERGRADUATE TOXICOLOGY EPA, Research Triangle Park, NC. Sponsor: S. COURSE. K. Willett. School of Pharmacy, Nadadur. University of Mississippi, University, MS. #708 4:56 AIR POLLUTION HEALTH EFFECTS: INPUT #714 5:12 LEANING WITH THE LEARNING CURVE: TO REGULATIONS. S. Vedal. Environmental TEACHING TOXICOLOGY ONLINE. J. and Occupational Health Sciences, University of Huggins. Bioscience and Biotechnology, Drexel Washington, Seattle, WA. Sponsor: S. Nadadur. University, Philadelphia, PA. #709 5:06 TOXICOLOGICAL PROFILES OF AMBIENT #715 5:28 IUPAC’S CONTRIBUTION TO DISTANCE PM AND GASES. T. Gordon. NYU School of LEARNING. J. Duffus. The Edinburgh Centre for Medicine, Tuxedo, NY. Toxicology, Edinburgh, Scotland, United Kingdom. #710 5:16 MIXTURES WE BREATHE: IMPLICATIONS #716 5:44 POSTGRADUATE TOXICOLOGY FOR AIR QUALITY ASSESSMENT AND EDUCATION VIA THE INTERNET. P. Wright2 MANAGEMENT. J. Vandenberg. NCEA, U.S. EPA, and D. J. Huggins1. 1Bioscience and Biotechnology, Research Triangle Park, NC. Sponsor: S. Nadadur. Drexel University, Philadelphia, PA and 2Key Centre for Toxicology, RMIT University, Melbourne, VIC, MONDAY Australia. Monday, March 6 4:30 PM to 6:00 PM Room 6C Monday, March 6 4:30 PM to 6:00 PM SUNSET SESSION: DISTANCE LEARNING IN TOXICOLOGY: Room 6F EFFECTIVE TEACHING THROUGH TECHNOLOGY SUNSET SESSION: TOXICOLOGY IN THE COURTROOM: Chairperson(s): Donna Jane Huggins, Drexel University, Philadelphia, ESTABLISHING CAUSATION, A ROUNDTABLE DISCUSSION PA and John Duffus, The Edinburgh Centre for Toxicology, Edinburgh, Scotland, United Kingdom. Chairperson(s): Richard Parent, Consultox Ltd., Damariscotta, ME, David Eaton, University of Washington, Seattle, WA and Bernard Goldstein, Endorsed by: University of Pittsburgh, Pittsburgh, PA. Career Resource and Development Committee Education Committee* Endorsed by: Women in Toxicology SS Ethical, Legal, and Social Issues SS Risk Assessment SS Distance learning has definitely come of age. On-line courses represent an impressive knowledge base which is now relatively easy to access by Currently both Federal and State courts are attempting to adequately college students as well as individuals seeking mid-life career changes define criteria for establishing or dismissing causal relationships between and/or advancement. Coupling electronic tools with teaching, asynchrony toxicological effects and exposures to various agents such as drugs and with synchrony, distance learning (asynchronous) courses can no longer chemicals. Although Federal and State courts in the Frye, Daubert and be ignored as registration for them expands and types of offerings prolif- Havner rulings have stiffened the requirements for causation, it is the Brad- erate. This rapid rate of development has, in many respects, resulted from ford Hill Criteria (established primarily for assessment of causation using an increased awareness and appreciation of these techniques by many epidemiological data) that have been the backbone for these efforts. Not teachers and students. The common-sense practicality associated with these surprisingly, application and interpretation of the Hill Criteria in the court- endeavors has dispelled much of the mysticism surrounding this area of room has been variable, often resulting in over reliance on epidemiological education. Moreover, distance learning has come down-to-earth for many evidence with a lesser role for the more controlled toxicological studies. people around the globe offering them opportunities for higher education From the court’s perspective, there are two types of “causation”: general that, heretofore, would never have been obtainable. Both the thinking and causation and specific causation. In the former, the court generally need the technological tools behind development of distance learning courses only ascertain that there is a reasonable scientific and/or medical basis to in toxicology will be presented. The speakers will be addressing on-line assume that the substance in question is capable causing the alleged injury, course content and delivery, nationally and internationally. Current on-line illness or disease in order for the case to move forward. Specific causation courses/programs will be discussed with respect to development, efficacy addresses the issue of a personal injury caused or not caused by a particular and quality. Asynchrony will be defined. drug or chemical within a reasonable degree of scientific or medical prob- up-to-date information at www.toxicology.org 113 -
Annual Meeting Annual th SOT's 45 SOT's
(Continued) Annual Annual U.S. Perspective—Regulatory DA Compliance Issues for Animals Used in Toxicological Research and Testing, Jodie Kulpa-Eddy, Animal DA U.S. and Plant Health Inspection Service, DA, U.S. Riverdale, MD. Using Animals for Toxicological Research and Testing: Best Practices for Assuring Compliance with Animal Welfare Regulations, Policies, and Guidelines, Axel NIH, Wolff, Bethesda, MD. AAALAC Perspective: Common Animal Careand Use Program and Facility Recommendations for Improvement for Toxicological Research and Testing Facilities, John Miller, AAALAC, Rockville, MD. Canadian Council on Animal Care Perspective: Compliance Issues and Best Practices for Animals Used for Toxicological Research and Testing, Clement Gauthier, Canadian Council on Animal Care, Ottawa, Canada. ON, The UK Home Office Perspective: Regulatory Compliance Issues andBest Practices for Animals Used for Toxicological Research andTesting, Jon Richmond, UK Home Office Animals Scientific Procedures Division, UK Home Office, London, United Kingdom. NJ. NJ. San Diego, CA. Kansas KS. City, th Post-Doctoral Assembly Post-Doctoral Career Resource and Development Committee Committee and Development Resource Career Your Your post-doctoral training has been a aheadblast, tobut thenow younext arestage thinkingfind ofyou help to tips providing ahead, decisions of maze the for youryou prepare career. This roundtable discussion will and The land formatthe job of want. you a this discus session will involve 4:30 PM to 6:00 PM Room 2 LIFE AND DEVELOPMENT SEMINAR: CAREER RESOURCE AND LANDING ON FINDING ADVICE POST-DOC: YOUR AFTER A JOB Kimbell, Julia CT; Groton, Pfizer, Thomas Kawabata, Chairperson(s): Scripps Luyendyk, PDA, NC; James Park, Triangle Research CIIT, Purdue PDA, Crossgrove, CA; and Janelle La Jolla, Institute, Research IN. Lafayette, West University, by: Endorsed • • • • • 6 March Monday, sion of key questions by a diverse panel academia sion of a questions of expertsdiverse by key from industry, After and the government. responses from the panel, the discussion will be session. This is intended to be a very interactive opened up to the audience. • Scott Loveless, DuPont Haskell Laboratories, Newark, DE. • William Greenlee, CIIT, Research Triangle Park, NC. • Gregory Cosma, Bristol Myers Squibb, New Brunswick, • Mark Zorbas, Pfizer Global Research and Development, • Linda Birnbaum, Research EPA, U.S. Triangle Park, NC. • Bryan Copple, University Kansas of Medical Center, 45 114 ------Meeting & ToxExpo & Meeting D. , D. 1 R. Parent Consultox Ltd., Consultox 1 . 3 Department Env Occup Health Occup Department Env 2 B. D. Goldstein D. and B. 2 Graduate School of Public Health, University of Health, University Graduate School of Public Science, University of Washington, Seattle, WA and WA Seattle, Washington, of Science, University Pittsburgh, Pittsburgh, PA. Pittsburgh, Pittsburgh, L. Eaton Damariscotta, ME, 3 TOXICOLOGY IN THE COURTROOM: THE COURTROOM: IN TOXICOLOGY A CAUSATION, ESTABLISHING DISCUSSION. ROUNDTABLE
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Animals in Research Committee* Animals in Research
Toxicological research and testing ofteninvestigate require mechanismsthe use of of toxicanimalssafety This assessments. animal use must be actionconducted toin accordance with and to accomplishapplicable regulatoryanimal welfare laws, policies, many organizations participateand in voluntary accreditation regulations. programs, which Additionally, also necessitates adherence to best practice standards based on guidelines published in the NRC/ILAR Guide for the Animals. These Care requirements and andguidelines seek Useto ensure that of investiga Laboratory Program Description Description Program Monday, March 6 March Monday, : Jan Oberdoerster, Bristol-Myers Squibb, East Syracuse, Squibb, East Syracuse, Bristol-Myers Oberdoerster, Chairperson(s): Jan NC. Park, Triangle Stokes, NIEHS, NIH, DHHS, Research William NY and by: Sponsored 4:30 PM to 6:00 PM Room 1A TOXICOLOGICAL ANIMALS FOR USING SPECIAL SESSION: ASSURING FOR BEST PRACTICES TESTING: AND RESEARCH REGULATIONS, WELFARE ANIMAL WITH COMPLIANCE AND GUIDELINES POLICIES, ability. Toxicological evidence Toxicological can ability. play a critical role in establishing both general and specific causation. The panelistsand limitations of will various types addressof toxicological and the epidemiological data strengths in the context of the causation issue. Issues relating discussed from in viewpoints various hopes some of insights providing and to causation will be clarifications for the bench and for litigants. The three participants in this roundtable are experienced in dealing with these issue both in the court ciation for the Assessment and Accreditation of Laboratory Animal Care International. The Canadian Council on Animal Care and the Office UK will Home provide international perspectives. Increased understanding of current animal care and use compliance issues and expected best practices will facilitate optimization of humane animal care and use by investigators and laboratory and animal minimize veterinarians, the of likelihood disrup mandatory actions. corrective tive tors use animals in the most humane and judicious manner consistent with successful attainment of the research or testing objectives, and consistent with current best practices for animal care and use. institutions However, face challenges in assuring adherence to best prac tices in the face of changing researchtechniques, and testing and objectives, animalpriorities, species,bioterrorism researchsuch asinitiatives. in They changes evolving responsein arebest practices for animal care also and use in areas such toas faced recentwith adheringmajor environmental enrichment,to consideration and use of alternatives, humane endpoints, management of pain and distress, and animal caging and envi ronment. This workshop will review the most commonuse deficiencies animal and suggestions care for improvement andcited by regulatory and accreditation authorities, and the current best practices used as benchmarks by these organizations for inspections and site visits use programs and of facilities. on Perspectives compliance animal issues and currentcare and best practices will be provided by U.S. DA APHIS/Animal Care (Animal Act regulations), Welfare NIH Office of Laboratory (PHS Animal Welfare Asso Animals), and the on the Humane Care and Use of Laboratory Policy room and elsewhere. #717 4:30
MONDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Monday, March 6 Monday, March 6 4:30 PM to 6:00 PM 7:15 PM to 8:30 PM Room 14B Room 11A
SPECIALTY SECTION PRESIDENTS MEETING REGULATORY AND SAFETY EVALUATION SPECIALTY SECTION: GREAT DEBATE: HUMAN AND ANIMAL TESTING: If you will be a President or a Vice President of a Specialty Section in WHAT’S APPROPRIATE? 2006–2007, please make plans to attend the Specialty Section President meeting scheduled for 4:30 PM–6:00 PM on Monday, March 6. The Speakers: Joe Rodricks, ENVIRON Health Sciences, Arlington, VA; John agenda for the meeting will include an overview of the SOT Long-Range Doull, University of Kansas Medical Center, Kansas City, KS; and Chad Plan. If you have long-range planning ideas that you would like added to Sandusky, Physicians Committee for Responsible Medicine,Washington, the agenda, please send a message to Rita Rose at SOT Headquarters. The DC. agenda will include information on the scientific session selection process, budgetary guides, a review of 2005–2006 activities, and plans for the The Regulatory and Safety Evaluation Specialty Section (RSESS) is plan- future. ning to have another “Great Debate.” The debate will be conducted after the business meeting at our Regulatory and Safety Evaluation Specialty Monday, March 6 Section reception. 5:00 PM to 8:00 PM Marriott Hotel & Marina San Diego Ballroom A Tuesday Morning
SPECIAL INTEREST GROUP MEETING/RECEPTION: AMERICAN ASSOCIATION OF CHINESE IN TOXICOLOGY: Tuesday, March 7 DISTINGUISHED CHINESE TOXICOLOGIST LECTURE 7:00 AM to 8:30 AM Room 14B Monday, March 6 5:30 PM to 8:00 PM REGIONAL CHAPTER PRESIDENTS MEETING Marriott Hotel & Marina Columbia Rooms 1 & 2 If you will be a President or a Vice President of a Regional Chapter in 2006–2007, please make plans to attend the Regional Chapters Presidents SPECIAL INTEREST GROUP MEETING/RECEPTION: meeting scheduled for 7:00 AM–8:30 AM Tuesday, March 7. The agenda KOREAN TOXICOLOGISTS ASSOCIATION IN AMERICA for the meeting will include an overview of the SOT Long-Range Plan. If you have long-range planning ideas that you would like added to the MONDAY agenda, please send a message to Rita Rose at SOT Headquarters. The agenda will include Headquarters administrative support information, Monday Evening budgetary guides, a review of 2005–2006 activities, and plans for the future.
Monday, March 6 Tuesday, March 7 6:00 PM to 7:30 PM 7:30 AM to 8:50 AM See Events Calendar on page 2-6 for Room Listings Room 2
SPECIALTY SECTION MEETINGS/RECEPTIONS: ROUNDTABLE SESSION: THE PRECAUTIONARY PRINCIPLE CARCINOGENESIS, DRUG DISCOVERY, —IMPLICATIONS AND APPLICATIONS IMMUNOTOXICOLOGY, MECHANISMS, MIXTURES REGULATORY AND SAFETY EVALUATION Chairperson(s): Steven Gilbert, Institute of Neurotox & Neurological Disorders, Seattle, WA. Monday, March 6 6:00 PM to 8:00 PM Endorsed by: Marriott Hotel & Marina Ethical, Legal, and Social Issues SS Marina Ballroom E The precautionary principle (PP) as an approach to decision making on issues related to environmental and human health is controversial. SPECIAL INTEREST GROUP MEETINGS/RECEPTION: However, the precautionary principle is receiving increased attention THE ASSOCIATION OF SCIENTISTS OF INDIAN ORIGIN IN in North America and Europe as a supplement to risk assessment. The AMERICA foundation of the precautionary principle can be expressed as the common- sense advice to “err on the side of caution.” It is intended to apply to a Monday, March 6 range of situations that involve both a threat of harm as well as scientific 6:00 PM to 8:00 PM uncertainty. While the PP may seems like common-sense to some to some See Events Calendar on page 2-6 for Room Listings people, others are concerned the application of the PP will needlessly increase costs and stifle technological advancements. This workshop REGIONAL CHAPTER MEETINGS/RECEPTIONS will start by providing an overview of the PP with historical examples of lessens learned. Next, is an examination of decisions making in the face of Many of the Regional Chapters meet during the SOT Annual Meeting. the uncertainty that often confronts issues of cause and effect. Alternatives Details for these Regional Chapter receptions and meetings are listed in the approaches such as green chemistry will be considered. Finally, there will Events Calendar. be a more critical examination of the PP with an opportunity for discus- up-to-date information at www.toxicology.org 115 - - - 1, , . Cal/EPA, L. Zeise. Cal/EPA, M. S. Golub
Environmental Environmental 2 Annual Meeting Annual th . Air Toxicology Toxicology Air M. Marty.
SOT's 45 SOT's Office of Environmental Health Hazard Office of Environmental 1 . Assessment, California Environmental Protection Assessment, California Environmental Sacramento, CA and Agency, NEURODEVELOPMENTAL TOXICITY TOXICITY NEURODEVELOPMENTAL CONTAMINANTS AND ENVIRONMENTAL AND RESEARCH IN CALIFORNIA’S PROGRAMS. REGULATORY Assessment, Health Hazard Office of Environmental CA. Oakland, OF CALIFORNIA’S IMPLEMENTATION HEALTH CHILDREN’S ENVIRONMENTAL ACT. PROTECTION DEVELOPING CHILD-SPECIFIC REFERENCE DOSES FOR SCHOOL SITE A. Knadle S. M. Siegel, D. ASSESSMENT. Sacramento, CA. 2 CA. THE ASSESSMENT OF CALIFORNIA’S IN LIFE EXPOSURE ON OF EARLY IMPACTS CARCINOGENIC POTENCY. OEHHA, Branch, Cal/EPA, and Epidemiology CA. Oakland, TO GOALS HEALTH PUBLIC CALIFORNIA’S AND CHILDREN FROM INFANTS PROTECT A. M. CONTAMINANTS. WATER DRINKING Health . OfficeA. Howd of Environmental and R. Fan Assessment, California Environmental Hazard CA. Oakland, Agency, Protection Carlisle. OEHHA, Cal/EPA, Chan and J. D. Toxicology, University of California, Davis, Davis, Davis, of California, Davis, University Toxicology,
Dr. Junying Yuan will Yuan present Dr. Junying the MRC lecture on cell death and neurodegeneration. Dr. Yuan is currently a professor of Cell Biology at Harvard Medical School. She initially trained at Fudan China University,and subsequentlyShanghai, obtained her PhD in Neuro science at HarvardNobel Prize Universitywinner H.R. Horvitz. working an SheInstructor continuedand with Assistantas Professor the of Harvard Medicine Medical at School, then became Associate and
and then in mammalian systems and has made fundamental (Continued) Annual Annual C. elegans th #725 7:45 #727 8:03 in contributions by discovering the caspase family of proteases and subse Tuesday, March 7 March Tuesday, Room 6A CELL MEDICAL RESEARCH COUNCIL (MRC) LECTURE: AND NEURODEGENERATION DEATH Boston, MA. Medical School, Harvard Yuan, : Junying Lecturer The UK Medical Research Council (MRC) sponsored lecture at the SOT Annual Meeting reflects the long tradition of support the MRC for by basic sciences and their translation to medicine. #726 7:54 #728 8:12 #729 8:21 8:00 AM to 8:50 AM AM to 8:50 8:00 now now full Professor of Cell Biology. Professor Yuan has pioneered studies concerning the mechanism of degeneration, regulation and cell death first quently by relating them to neurodegenerative conditions. More she recently has used unbiased chemical genetic screens to identify new regulatory machineries controlling the process leading to cell death. She has fied identi both new death pathways and chemicals that may be used to prevent the onset of non-apoptotic cell death. Her is work of great to relevance cell biology, medicine and toxicology. Dr. Yuan has published an impressive 45 116 - -
Meeting & ToxExpo & Meeting . . 2 S. G. S. G. G. E. E. G.
Graduate 2 S. G. Gilbert S. G. and A. de Peyster 1 INND, Seattle, WA and WA Seattle, INND, . Human Health 1 . 2
. G. V. Alexeeff V. G. J. L. Mattsson J. . VM-APC, . Fanucchi V. and M. S. Gilbert J. L. Mattsson and J. 1 OEHHA, Cal/EPA, Oakland, CA and Oakland, OEHHA, Cal/EPA, Dow AgroSciences, Indianapolis, IN. Dow University of California, Davis, CA. of California, Davis, University CALIFORNIA. 1 Sponsor: PRINCIPLE. THE PRECAUTIONARY PRINCIPLE: PRINCIPLE: THE PRECAUTIONARY APPLICATIONS. AND IMPLICATIONS Gilbert 2 THE TO AN INTRODUCTION PRINCIPLE. PRECAUTIONARY Assessment, Dow AgroSciences, Indianapolis, IN. Assessment, Dow C. G. Plopper C. G. . Arizona State University College of Law, of Law, College Arizona State University . Marchant AZ. Tempe, DEVELOPING GREEN CHEMISTRY: TO ALTERNATIVES SUSTAINABLE Collins. T. TECHNOLOGIES. POLLUTING PA. Pittsburgh, Carnegie University, Mellon AND DEVELOPMENT OF RESEARCH ASSESSMENT IN CHILD SPECIFIC RISK INND, Seattle, WA. Seattle, INND, OF LIMITATIONS AND ASPIRATIONS PRINCIPLE. THE PRECAUTIONARY THE HAZARDS OF THE PRECAUTIONARY THE PRECAUTIONARY THE HAZARDS OF School of Public Health, San Diego State University, State University, Health, San Diego School of Public CA. San Diego, OF ENVIRONMENTAL IMPACTS THE DEVELOPING LUNG. CHEMICALS ON
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Risk Assessment SS* Risk Regulatory and Safety Evaluation SS Regulatory and Safety Evaluation Recent California laws require child-specific risk protectionassessments of to infants ensure and children as well as Further,other several sensitive populations.California institutions are conducting research to ascer : George Alexeeff, CAL EPA, Oakland, CA and Ann de Oakland, CA and CAL EPA, Alexeeff, Chairperson(s): George CA. San Diego, State University, San Diego Peyster, by: Endorsed Room 7B AND DEVELOPMENT OF RESEARCH SESSION: ROUNDTABLE IN CALIFORNIA CHILD-SPECIFIC PROTECTION 7:30 AM to 8:50 AM AM to 8:50 7:30 #719 7:30 sion of the applications and implications of widespread use of the PP as an approach to decision making. #718 7:30 Tuesday, March 7 March Tuesday, #721 8:00 tain infant and child-specific recentvulnerabilities. work on Researchersascertaining willdevelopmental those discussvulnerabilities,pertaining to the particularlylungs, nervous system, Evaluationand cancer of susceptibility. child-specific vulnerabilitieschild-specific has leadtoxic toair thecontaminants, listing new risk of guidelinesto infants5 forand children evaluatingand new air standards for ozone. These particulate activities have lead to matter new proposed and guidelines for site miti gation and a reevaluation of water contaminantwill levels.provide Thisother scientistssymposium with information on recent California. developments in #723 7:30
#720 7:45 Program Description Description Program #722 8:15 #724 7:35
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) number of high-quality papers and is regarded as one of the leading figures inhaled and nasal drug products (OINDP) that are developed for delivery in the research field of cell death. of drug substance directly to the respiratory or nasal tract to treat either a respiratory or nasal condition, or a systemic disease. Examples of OINDP The MRC was established in 1913 and scientists funded by the MRC at its include metered dose inhalers, dry powder inhalers, solutions/suspensions Units and institutes as well as in several UK universities have discovered for nebulization, and nasal sprays. In OINDP, the drug substance is usually fundamental processes in cell biology and medicine. The MRC supports contained in a delivery device that may contain polymers, elastomers, and research carried out in universities and other academic establishments in other components from which minute quantities of material may migrate the UK and through its intramural programme supports strategic research (leach) into the product and be delivered to the sensitive surfaces of the in Units and Institutes. The MRC Toxicology Unit was formed in 1947 respiratory and/or nasal tract along with the therapeutic agent. While every and is currently located at the University of Leicester where it integrates effort is taken to reduce the levels of these leachables, complete removal competitive research areas in cell biology, molecular biology, genetics is not possible. Because leachables are non-drug-related impurities, there and medicine. The Unit is pleased to sponsor a lecture at the SOT Annual is an increased concern for human risk by inhaling them on a daily basis. Meeting to acknowledge the importance of fundamental sciences and its Historically, acceptable levels of leachables in OINDP have been set by medical applications to the field of toxicology. negotiation with regulatory authorities on a case-by-case basis with no standard guidelines available. Recently, safety thresholds for risk assess- Tuesday, March 7 ment of leachables have been developed through a joint effort of USFDA, 8:30 AM to 9:30 AM academia and industry scientists and have addressed current concepts, Room 11A background, historical use and development of safety thresholds and their utility in qualifying leachables in OINDP. INFORMATIONAL SESSION: BIOLUMINESCENT METHODS #730 9:00 DEVELOPMENT OF SAFETY FOR ADME/TOX QUALIFICATION THRESHOLDS AND THEIR D. Presented by: Promega Corporation USE IN DRUG PRODUCT EVALUATION. J. Ball1 and R. O. McClellan2. 1Safety Sciences, Bioluminescence offers significant advantages for configuring sensitive, Pfizer, Inc., Groton, CT and 2College of Pharmacy, simple to perform high through-put assays. Bioluminescent systems will be University of New Mexico, Albuquerque, NM. described that measure the impact of test compounds on xenobiotic metab- #731 9:05 CONCEPT, HISTORY AND APPLICATION OF olizing enzymes, including cytochrome P450s and monoamine oxidase SAFETY THRESHOLDS. D. Jacobson-Kram. (MAO), and on the multi-drug transporter (MDR1/Pgp). Each system relies Center for Drug Evaluation, U.S. Food and Drug on the light generating reaction of firefly luciferase. Pgp-GloTM uses lumi- Administration, Rockville, MD. nescence to measure ATP consumption by the Pgp ATPase. P450-GloTM and MAO-GloTM use a series of selective luminogenic probe substrates for #732 9:40 EXTRACTABLES AND LEACHABLES IN CYP1A1, 1A2, 1B1, 2C8, 2C9, 2C19, 2D6, 2J2, 3A4, 3A5, 3A7, 4A11 and THE PHARMACEUTICAL DEVELOPMENT 4F12 and for MAO A and B. These assays are used to measure inhibition of PROCESS. D. L. Norwood. Analytical Sciences, recombinant P450s and MAOs and of native enzymes in liver microsomes. Boehringer Ingelheim Pharmaceuticals, Inc., P450-GloTM also provides a novel high throughput method for measuring Ridgefield, CT. Sponsor: D. Ball. P450 gene induction at the P450 enzyme level. This suite of homogeneous luminescent assays is sensitive, robust and convenient for small scale and #733 10:15 SAFETY THRESHOLDS FOR LEACHABLES high throughput applications. IN ORALLY INHALED AND NASAL DRUG PRODUCTS (OINDP). W. Vogel. Safety Sciences, Pfizer, Inc., Ann Arbor, MI. Tuesday, March 7 9:00 AM to 12:00 NOON #734 10:50 USE OF SAFETY THRESHOLDS IN THE Room 2 PHARMACEUTICAL DEVELOPMENT PROCESS FOR OINDP: AN INDUSTRY SYMPOSIUM SESSION: DEVELOPMENT OF SAFETY PERSPECTIVE. J. D. Blanchard. Safety QUALIFICATION THRESHOLDS AND THEIR USE IN DRUG Evaluation, Aradigm Corporation, Hayward, CA. PRODUCT EVALUATION #735 11:25 USE OF SAFETY THRESHOLDS IN THE Chairperson(s): Douglas Ball, Pfizer Global Research & Development, PHARMACEUTICAL DEVELOPMENT Groton, CT and Roger McClellan, Toxicology and Human Health Risk PROCESS FOR OINDP: A REGULATORY TUESDAY Analysis, Albuquerque, NM. PERSPECTIVE. T. McGovern. Center for Drug Evaluation, U.S. Food and Drug Administration, Endorsed by: Rockville, MD. Sponsor: D. Ball. Inhalation SS Regulatory and Safety Evaluation SS* Risk Assessment SS
Analytical techniques are sophisticated and capable of detecting and iden- tifying chemicals at picogram quantities. However, it is generally accepted that there are levels of many chemicals below which the risks to human health are so negligible as to be of no consequence. This rationale has been the impetus for development of safety thresholds for regulating chemicals to which humans are exposed. Safety thresholds have a history of use in regulatory applications, most notably in guidelines for food packaging. Recently, such thresholds have been developed for application to pharma- ceutical drug products. One of these applications is for leachables in orally up-to-date information at www.toxicology.org 117 -
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University University Program 2 3 1, 2 S. Orrenius Laboratory 4 Annual Meeting Annual th and S. Orrenius M. W. Fariss W. M. Institute of Environmental Institute of Environmental 5 1, 3 SOT's 45 SOT's , M. Patel 4 .
Pharmaceutical Sciences, University of Colorado Pharmaceutical Sciences, University Health Sciences Center, Denver, CO., CO., Denver, Health Sciences Center, Fariss Institute of Environmental Medicine, Karolinska Institute of Environmental Institutet, Stockholm, Sweden. AND DNA OF MITOCHONDRIAL ROLE OXIDATIVE TOXIC TELOMERASE IN B. Van Houten and J. H. Houten and J. Van STRESS RESPONSES. B. Santos. Laboratory of Molecular Genetics, NIEHS, NC. Sponsor: Park, Triangle NIH, Research 1 of Molecular Genetics, National Institute of Research Health Sciences, NIH, Environmental NC and Park, Triangle Medicine, Division of Toxicology, Karolinska Toxicology, of Medicine, Division Institutet, Stockholm, Sweden. OF MITOCHONDRIAL ROLE PROTECTIVE STRESS. OXIDATIVE TOXIC E IN VITAMIN Van Houten Van ROLE OF MITOCHONDRIA IN TOXIC TOXIC IN OF MITOCHONDRIA ROLE STRESS. OXIDATIVE . Pharmaceutical Sciences and Cancer Fariss W. M. of Colorado Health Sciences University Center, CO. Denver, Center, THE AND STATE REDOX MITOCHONDRIAL APOPTOSIS. OF REGULATION of Colorado Cancer Center, University of Colorado University of Colorado Cancer Center, CO., Denver, Health Sciences Center, Health of Colorado in Neuroscience, University CO., Denver, Sciences Center,
SS (Continued) Annual Annual th Mechanisms SS* Neurotoxicology SS Neurotoxicology In Vitro In Considerable Considerable experimental and clinical evidence supports the importance of mitochondria and mitochondrial oxidative damage induced stress-related diseases, including many as oxidative in toxic and event a critical target by toxicants. For example, antioxidantsdirected to suchmitochondria as have vitaminbeen shown E to oxidative derivativesprotectstress. Though cells the againstcritical mitochondrial toxic events responsible for oxidative stress-mediated cell injury have and yet to deathbe defined, (toxicoxidative damage to oxidative mitochondrial lipids, stress)nucleic acids and proteins appear to be important events in these toxic processes. The purpose of this Symposium is to report recent experimental evidence defining how mitochondrial responses to oxidative stress such as mito #744 10:40 9:00 AM to 12:00 NOON 9:00 Room 8 TOXIC IN OF MITOCHONDRIA ROLE SYMPOSIUM SESSION: STRESS OXIDATIVE Sciences Health of Colorado University Fariss, Chairperson(s): Marc Denver, of Colorado, University Patel, CO and Manisha Denver, Center, CO. by: Endorsed #742 9:20 Tuesday, March 7 March Tuesday, chondrial cardiolipin oxidation/depletion, persistent mitochondrial can lead to cell injury and damage and mitochondrial aconitase inactivation DNA a death. With better understanding of the critical molecular (targets) events in mitochondria responsible for stress, toxic oxidative can we look forward therapies. protective of more effective to the development #741 9:00 #743 10:00 45 118 - , 2 Meeting & ToxExpo & Meeting . . WIL 4
M. Kallman , C. Markgraf Neurology, Neurology, 1 3 C. Markgraf Pharmacology Pharmacology 1 . 3 . M. J. Kallman M. J.
. Pharmacology Kallman. Pharmacology M. J. Safety Pharmacology, Schering- Safety Pharmacology, 2 and J. Arezzo and J. 4
Research Labs, Ashland, OH. Ashland, Research Labs, ASSESSMENT OF PRECLINCIAL SAFETY WITH CANDIDATES PHARMACEUTICAL SEIZURE-GENIC POTENTIAL. Albert Einstein University, New York and York New Albert Einstein University, Toxicology Research, Lilly Research Labs, Research Research, Lilly Toxicology Greenfield, IN, REDUCING ADVERSE CLINICAL RISK CLINICAL RISK ADVERSE REDUCING FOR CONVULSION BY UNDERSTANDING AND POTENTIAL EVENTS PREMONITORY Schering Plough Research Institute, Lafayette, NJ. Schering Plough Research Institute, Lafayette, A AS EEG MEASURES NON-INVASIVE Arezzo. C. OF SEIZURES. J. PREDICTOR Albert Einstein Neuroscience and Neurology, NY. York, of Medicine, Bronx, New College BIOMARKERS. Sponsor: C. Markgraf G. Schafer Plough Res Institute, Lafayette, NJ, NJ, Plough Res Institute, Lafayette, RISK ASSESSMENT AND REGULATORY AND REGULATORY ASSESSMENT RISK OF CONVULSIVE IMPLICATIONS NEUROTOXICITY. Toxicology Research, Lilly Research Labs, Research, Lilly Toxicology Greenfield, IN. OF CLINICAL SEIZURE ASSESSMENT RISK and A. S. Chappell. Eli Lilly POTENTIAL. Sponsor: Indianapolis, IN. Company, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Risk Assessment SS Risk Neurotoxicology SS* Neurotoxicology Regulatory and Safety Evaluation SS Evaluation Regulatory and Safety Biological Modeling SS Biological #737 9:15 This symposium will focus on a approaches risk for assessment developing around the adverse occurrance of convulsion agent. State of the art forunderstanding of non-clinical to clinical modeling aof new pharmaceutical convulsion and strategies for providing clinical safety will be A discussed. on new perspective recent interactions liabili with around FDA convulsive #739 10:25 #738 9:50 : Mary Kallman, Eli Lilly & Company, Greenfield, IN and Greenfield, & Company, Chairperson(s): Mary Kallman, Eli Lilly NJ. Lafayette, Institute, Research Plough Schering Carrie Markgraf, by: Endorsed 9:00 AM to 12:00 NOON 9:00 Room 6E AND REGULATORY ASSESSMENT RISK SYMPOSIUM SESSION: OF CONVULSIVE NEUROTOXICITY IMPLICATIONS Tuesday, March 7 March Tuesday,
ties and potential pharmaceutical industry will be provided. clinical risk associated with convulsion strategies for mitigating the #736 9:00 Program Description Description Program #740 11:00
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #745 11:20 ROLE OF MITOCHONDRIAL ACONITASE #749 10:20 DEVELOPING LIPIDOMICS DATABASES IN TOXIC OXIDATIVE STRESS. M. Patel. AND NETWORKS. E. Fahy. Bioinformatics, Pharmaceutical Sciences, University of Colorado UCSD, La Jolla, CA. Sponsor: M. Madden. Health Sciences Center, Denver, CO. #750 10:55 COUNTER-REGULATION OF INFLAMMATORY RESPONSES BY LIPID- Tuesday, March 7 ACTIVATED NUCLEAR RECEPTORS. C. K. 9:00 AM to 12:00 NOON Glass. Cellular and Molecular Medicine, UC San Room 1A Diego, La Jolla, CA. Sponsor: M. Madden.
WORKSHOP SESSION: COMPREHENSIVE RESPONSES OF #751 11:30 EICOSANOMICS: SIMULTANEOUS LIPIDS CLASSES TO TOXICANTS AND INVOLVEMENT IN PROFILING OF BIOACTIVE EICOSANOIDS DISEASES PRODUCED BY CYCLOOXYGENASE-2. L. Marnett2 and M. C. Madden1. 1ORD, NHEERL, Chairperson(s): Michael Madden, U.S. EPA, Chapel Hill, NC and Ronald HSD, Clinical Research Branch, U.S. EPA, Riley, USDA, Athens, GA. Chapel Hill, NC and 2A.B. Hancock Jr. Memorial Laboratory, Vanderbilt Institute of Chemical Endorsed by: Biology, Nashville, TN. Mechanisms SS
Along with genes and proteins, lipids are a key component of the cellular Tuesday, March 7 metabolome. Lipids can mediate the induction of some diseases such as 9:00 AM to 12:00 NOON atherosclerosis and also responses to some diseases, e.g., asthma. Pollutants Room 5B such as ozone appear to induce biological responses through altered lipid metabolism. Examining changes in global lipid metabolism, i.e., lipido- WORKSHOP SESSION: DISCOVERY TOXICOLOGY: mics, induced by a pollutant or in a disease state would assist in elucidating STRATEGIES IN THE NEW DRUG DISCOVERY PARADIGM the mechanism(s) of responses. Understanding lipid metabolic changes would allow assessment of whether the response was of a highly specific or Chairperson(s): Thomas Jones, Eli Lilly & Company, Greenfield, IN and not, and provide information as to the sensitivity of the lipid measurement, Vito Sasseville, Millennium Pharmaceuticals, Inc., Cambridge, MA. thereby indicating the usefulness as a biomarker. Inherent in this strategy to Endorsed by: study lipidomics is the ability to 1) possess a knowledge of the metabolism Drug Discovery SS* of 1000 or more lipids in order to optimize lipid study design; 2) measure the lipids in a specific and quantitative manner, including development of The duration from initial synthesis of a new chemical entity (NCE) to the new methods to analyze newly discovered species; and 3) transfer of the delivery of an innovative therapeutic to the patient is becoming longer (9- lipid data to the informatics stage. This session will include presentations 12 years) with estimated total costs rapidly approaching $1 billion. The with findings related to the topics discussed above. These topics include financial investment grows exponentially as an NCE advances through the structural diversity of lipids, methodologies to quantitate lipid species the discovery and development process. A major cause of compound and classes, how the data from studies examining global changes in lipid failure during the pre-clinical and clinical development phases is toxicity. metabolism can be processed to allow interpretation of the findings, and Estimates regarding toxicology-driven attrition during the drug develop- the use of endotoxin-exposed macrophages in vitro to validate the lipido- ment process range from 20-40%. Therefore, the opportunity exists for mics approach. Another topic that will be presented will be the involvement the toxicologist to significantly impact expenditures by the early predic- of oxidized lipids (derived via oxidative stress) in several disease states tion of potential toxicity/side effect barriers to development by aggressive (cancer, cardiovascular disease). These topics will be presented by five evaluation of development limiting liabilities early in drug discovery. researchers of the LIPID MAPS (Metabolite And Pathways Strategy) Improved efficiency in pharmaceutical research and development lies Project, which funds investigators at more than 16 academic institutions both in leveraging “best in class” technology and integration with phar- and 2 corporations to collaboratively research lipidomics using disciplines macologic and medicinal chemistry activities during hit-to-lead and early such as cell biology and organic synthesis. [This abstract may not reflect lead optimization stages. This workshop will provide an overview of official EPA policy.] the various strategies being applied to integrate toxicology in the drug #746 9:00 COMPREHENSIVE RESPONSES OF discovery process. The presentations will provide a greater understanding
LIPID CLASSES TO TOXIANTS AND of the causes and timing of toxicology-driven attrition in drug development TUESDAY INVOLVEMENT IN DISEASES. M. C. Madden. and how the discovery toxicologist can better interface with the pharma- ORD, NHEERL, HSD, Clinical Research Branch, cologist and medicinal chemist. Topics which will be covered in detail U.S. EPA, Chapel Hill, NC. include in vitro and in vivo screening approaches, the use of high content technologies (i.e., genomics), in silico approaches to predictive toxicology, #747 9:10 THE LIPID MAPS APPROACH TO and the application of alternative animal models (transgenic animals, gene LIPIDOMICS: EICOSANOIDOMICS AND knockdown/knockout models, non-mammalian species, etc.), and finally, LIPID CLASSIFICATION. E. A. Dennis. examples of integrated discovery toxicology approaches currently being Chemistry & Biochemistry, and Pharmacology, used in the industry. University of California, San Diego, La Jolla, CA. Sponsor: M. Madden. #752 9:00 PREDICTIVE TOXICOLOGY: STRATEGIES IN THE NEW DRUG DISCOVERY #748 9:45 CHALLENGES IN THE ANALYSIS OF PARADIGM. T. W. Jones1 and V. G. Sasseville2. 1Eli COMPLEX MIXTURES OF LIPIDS PRESENT Lilly and Company, Greenfield, IN and 2Millennium IN BIOLOGICAL EXTRACTS. R. C. Murphy. Pharmaceuticals, Inc., Cambridge, MA. Pharmacology, University of Colorado, Aurora, CO. Sponsor: M. Madden. up-to-date information at www.toxicology.org 119 - - -
S. D. S. D.
Annual Meeting Annual th , structure function and and E. Hudgens. i.e. , i.e. ‘macrofoods/macronutrients, SOT's 45 SOT's . Gradient Corporation, and A. Schoen Finally, the breadth of novel ingredients , M. Cano and T. Ohnishi. T. , M. Cano and Arnold , L. L. etc.
B. D. Beck D. B. Cambridge, MA. MMA AS, OF PROFILE GENOTOXIC Rossman. Nelson Institute of G. T. AND DMA. University York Medicine, New Environmental NY. Tuxedo, School of Medicine, IN ARSENICALS OF CARCINOGENICITY ANIMAL MODELS. AND HUMANS Cohen Thomas J. R. Calderon, D. National Health & Environmental Effects Research Effects National Health & Environmental Office of Research & Development, Laboratory, NC. Park, Triangle Research EPA, U.S. METABOLISM AND TOXICITIES OF TOXICITIES AND METABOLISM AS SPECIES. AND ORGANIC INORGANIC Department of Pathology and Microbiology, and Microbiology, Department of Pathology Omaha, NE. Nebraska Medical Center, of University AND CLINICAL EFFECTS. EPIDEMIOLOGY
or case-specificde novo The current fashion.food ingredient
(Continued) Annual Annual th Food Safety SS Food health) have unlocked new dimensions in food Ingredients ingredientnever before used development. or contemplated, such as low carbohydrate starches, new artificial sweeteners, unusual vegetable oils, bioticpre- and bacteria,pro- and botanical extracts,investigation areand now development. the Adequate subjectsdemonstration of be ofintensedriven, by safetythe regulations mustin place, so that each in a evaluated new ingredient is not regulations are able to examine macronutrients, modified oils carbohydrates,and proteins, functional (to the human body) ingredients, botan novel 9:00 AM to 12:00 NOON 9:00 Room 1B NEW FOOD INGREDIENTS DO NOT SESSION: WORKSHOP NEED NEW FOOD REGULATIONS FL and Beach, Vero Group, Griffiths, Burdock Chairperson(s): James IL. Chicago, Jr Company, Wrigley William Vollmuth, Thomas by: Endorsed #760 9:45 #761 10:20 Consumer demands for newer and better foods puts considerable pres Tuesday, March 7 March Tuesday, #759 9:10 ical extracts, and competitive bacteria for safety-in-use as a food ingredient.food a as safety-in-use for bacteria competitive and extracts, ical The safety of the food containinghowever, the a rolenew ingredientof an can individualamount be of a addressed;over-consumingsingular food or food a type, disproportionate ’ can only be handled by modifications to exposure patterns. and Definitions regulatory status of nutrients, foods fortificants,will be functional,discussed. Additionally, and qualifiedmedical claims on these andand other food ingredients are the driving need un-qualifiedto establish health efficacy via robust and well-designed studies clinicalin support of the studies.safety and efficacy Evento human test withpopulations, an these reportingadverse event system needs to consider the long-term monitoring of sensitive subpopulations, over-consumption, alternative uses, drug/food interactions, nutrigenomics entering and the their food assessment supply, for safety under the aegis of current regulatory paradigms will be discussed. #762 10:55 sure on food technicians, and the food industry as a whole, to satisfy this demand for an endless supply of novel food ingredients. Recent develop ments in ‘fad diets’ and functional claims ( 45 120 - Meeting & ToxExpo & Meeting J. J.
J. Xu. Pfizer J. via the same or . Abernathy Associates, Abernathy . Abernathy C.
, S. Abel and E. Blomme. Abbott Abel and E. Blomme. , S. Yang , Y. . .
APPLICATION OF TOXICOGENOMICS TOXICOGENOMICS OF APPLICATION SAFETY EVALUATION. DRUG TOWARDS Inc., Cambridge, MA. ADMET, WHO USES IT AND WHO USES IT ADMET, IN SILICO Stradella. Ryan, L. HermanWHEN? D. and O. Millennium Computational Chemistry, Pharmaceuticals, MA. Sponsor: T. Inc., Cambridge, Jones APPROACHES: SCREENING VITRO IN IN DISCOVERY. APPLICATIONS Bristow, VA. Bristow, Laboratories, Abbott Park, IL. Abbott Park, Laboratories, APPROACHES: TOXICOLOGY DISCOVERY G. V. PRACTICE. INTO PUTTING STRATEGY Alden. Drug Kadambi and C. V. Lane, J. Sasseville, Pharmaceuticals, Millennium Safety Evaluation, F. Waring F. OF INORGANIC THE METHYLATION DOES AND TOXICITY AFFECT ITS ARSENIC A CRITICAL ACTION? MODE(S) OF DISCUSSION. Research and Development Center, Cambridge, MA. Center, Research and Development IN DRUG METABOLITES REACTIVE AND DEVELOPMENT. DISCOVERY AND ROLE IDENTIFICATION, DETECTION, A. T. DESIGN OF SAFER DRUGS. THE IN Sponsor: T. PA. Point, West Baillie. Merck & Co., Jones
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Risk Assessment SS Risk Metals SS * Carcinogenesis SS Carcinogenesis Considerable controversy exists arsenicover the(As). Various risk questionsassessment include: linear risk of assessment 1). be ingestedemployed? 2). ShouldDo the inorganic a and the linear organic or(i.e., monomethyl a arsonic acid non- (MMA) and dimethylarsinic acid (DMA)) arsenicals similar have modes of action? and 3). How much weight should be assigned to the relativelypotential smallof inorganic USAs and studies?its various In metabolites chronicthisto causeeffects workshop, acute to and the humans and in particular animalinterest will modelsbe a willcontrast of be exposures described.to inorganic organic As arsenical, DMA, Ofand and discussion an of whether such exposures would be expected to result in similar or dissimilar toxic effects different different toxic mechanisms. After considering these questions, the epide : Barbara Beck, Gradient Corporation, Cambridge, MA Cambridge, Corporation, Gradient Beck, Chairperson(s): Barbara VA. Associates, Bristow, & Abernathy Abernathy, and Charles by: Endorsed Room 5A OF THE METHYLATION DOES SESSION: WORKSHOP AND MODE(S) TOXICITY AFFECT ITS ARSENIC INORGANIC A CRITICAL DISCUSSION ACTION? OF #756 10:50 7 March Tuesday, AM to 12:00 NOON 9:00 #754 9:40 #753 9:05 #757 11:25
miological miological data will be evaluated to ascertain how such data can be to used support the theories put forth concerning As At toxicity. the end of the session for the attendees. there will be a question and answer workshop, #758 9:00 Program Description Description Program #755 10:15
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #763 9:00 NEW FOOD INGREDIENTS DO NOT NEED model to test more complex chemicals and product formulations, there is a NEW FOOD REGULATIONS. J. C. Griffiths1, desire to advance the LLNA to evaluate a larger variety of materials. This J. A. Thomas5, J. F. Borzelleca3, I. G. Carabin4, R. workshop will consider how the LLNA has fared in its use as a stand-alone A. Matulka1 and A. S. Persad1. 1Burdock Group, predictor of dermal sensitization potential, including presentation of exper- Washington, DC, 2Office of Food Additives Safety, imentation that has been evaluated to increase the utility of this model. Food and Drug Administration, College Park, MD, 3 #769 9:00 REGULATORY APPLICATION OF THE Department of Pharmacology and Toxicology, MOUSE LLNA: NEW CHALLENGES AND Virginia Commonwealth University, Richmond, VA, 2 4 OPPORTUNITIES. G. S. Ladics and M. R. Women Health Sciences Institute, Vero Beach, FL 1 1 5 Woolhiser . Toxicology & Environmental Research and Department of Pharmacology and Toxicology, and Consulting, The Dow Chemical Company, Indiana University, Indianapolis, IN. Midland, MI and 2DuPont Haskell Laboratories, #764 9:15 DRUG-NUTRIENT INTERACTIONS Newark, DE. - RECOGNIZING PHARMACOLOGIC #770 9:05 PERFORMANCE AND VALIDATION OF THE IMPLICATIONS. J. A. Thomas. Department of LOCAL LYMPH NODE ASSAY. I. Kimber. Pharmacology and Toxicology, Indiana University, Syngenta Central Toxicology Laboratory, Cheshire, Fishers, IN. United Kingdom. #765 9:48 MACRONUTRIENTS AND #771 9:40 REGULATORY EXPERIENCE OF TESTING MACRONUTRIENT SUBSTITUTES IN NEW, INDUSTRIAL CHEMICALS WITH THE TODAY’S DIETS. J. F. Borzelleca. Pharmacology LLNA. A. Cockshott. Health and Safety Executive, and Toxicology, Virginia Commonwealth University, Bootle, United Kingdom. Sponsor: M. Woolhiser. Richmond, VA. #772 10:15 CONSIDERATIONS FOR #766 10:21 FORTIFICANTS, NUTRIENTS, MEDICAL PHARMACEUTICAL PRODUCTS AND THE AND FUNCTIONAL FOODS: THE ALPHABET LOCAL LYMPH NODE ASSAY (LLNA). A. SOUP. A. Mattia. U.S. FDA/CFSAN, College Park, Jacobs. CDER, U.S. Food and Drug Administration, MD. Sponsor: J. Griffiths. Rockville, MD. #767 10:54 CLINICAL DATA AS A NEW REQUIREMENT #773 10:50 APPLICATION OF LLNA DATA IN SKIN FOR FOOD INGREDIENT SAFETY. I. Carabin. SENSITIZATION RISK ASSESSMENT. G. Women’s Health Sciences Institute, Vero Beach, FL. Gerberick. Miami Valley Laboratories, Procter & Sponsor: J. Griffiths. Gamble Company, Cincinnati, OH. #768 11:27 SAFETY EVALUATION OF A NOVEL #774 11:25 LLNA EXPERIENCE FOR COMPLEX INGREDIENT: PROBIOTIC AND NON- CHEMISTRIES AND MIXTURES. M. R. PROBIOTIC BACTERIA ADDED TO FOOD. R. Woolhiser. Toxicology & Environmental Research A. Matulka. Burdock Group, Vero Beach, FL. and Consulting, The Dow Chemical Company, Midland, MI. Tuesday, March 7 9:00 AM to 12:00 NOON Tuesday, March 7 Room 7B 9:00 AM to 12:00 NOON Room 6C WORKSHOP SESSION: REGULATORY APPLICATION OF THE MOUSE LLNA: NEW CHALLENGES AND OPPORTUNITIES PLATFORM SESSION: AH RECEPTOR III
Chairperson(s): Michael Woolhiser, Dow Chemical Company, Midland, MI Chairperson(s): Richard S. Pollenz, University of South Florida, Tampa, and Gregory Ladics, DuPont Haskell Laboratories, Wilmington, DE. FL and Robert Tukey, University of California San Diego, LaJolla, CA. Endorsed by: #775 9:00 FUNCTIONAL ANALYSIS OF ARNT2 IN
Dermal Toxicology SS AH RECEPTOR-MEDIATED SIGNAL TUESDAY Immunotoxicology SS* TRANSDUCTION. E. J. Dougherty and R. S. Regulatory and Safety Evaluation SS Pollenz. Biology, University of South Florida, Tampa, FL. Since 2002, adoption of the mouse Local Lymph Node Assay (LLNA) as a stand-alone test to evaluate dermal sensitization potential for industrial #776 9:20 FUNCTIONAL ANALYSIS OF THE chemicals occurred globally (e.g., U.S. EPA OPPTS 870.2600 & OECD TCDD-INDUCIBLE CYP1A1 PROMOTER/ TG 429). The LLNA is now endorsed internationally as the preferred, and ENHANCER REGION FROM ZEBRAFISH in some cases mandated, approach replacing the Magnusson and Kligman (DANIO RERIO). G. ZeRuth and R. S. Pollenz. (M&K) Maximization and Buehler guinea pig methods due to animal Biology, University of South Florida, Tampa, FL. welfare benefits, and the use of more objective and quantitative measure- #777 9:40 TRANSCRIPTIONAL REGULATION OF IL-8 ments. Moreover, the LLNA lends itself more readily to assess the relative BY AH-RECEPTOR ACTIVATION. C. Vogel1, potency of skin sensitizers. This aspect has led to proposals of the LLNA as E. Sciullo1, P. Wong1, L. Wen1, G. Lazennec2 and a possible addition to risk assessment schemes. While years of evaluation F. Matsumura1. 1ETOX, UC Davis, Davis, CA and using purified, characterized chemicals have suggested the LLNA is overall 2Molecular and Cellular Endocrinology, INSERM, slightly more accurate than guinea pig tests, its effectiveness at testing Montpellier, France. novel chemicals since its broad acceptance is beginning to be evaluated. There is little to no published data on the testing of materials such as poly- mers or complex chemical mixtures. With the objective of using the same up-to-date information at www.toxicology.org 121
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, . 2 1 H. , 2 , . 1 1 . . , J. A. , J. 1 , T. Kanno T. , , R. W. Hu , W. 3 1 1 , A. Cordier 1 BioMarker BioMarker 1 . Department of 1 S. Mueller 1 , D. R. Roth , D. . 1 2 , F. Legay , F. , A. B. Gibson A. B. , 1 2 , P. Taggart, L. Taggart, , P. X. Feng Annual Meeting Annual th and D. H. Phillips and D. , O. Grenet , O. 4 and A. Loguinov and 1 1 , S. Chibout 1 Osaka Prefecture University, Osaka Prefecture University, , M. Kawanishi 3 2 USACE Engineer Research and USACE , E. Perentes German Cancer Research Center, German Cancer Research Center, National Cancer Center Research 2 and G. Maurer 1 2 4 1 , P. Grass , P. SOT's 45 SOT's 2 Iconix Pharmaceuticals, Mountain 2 J. A. Steevens , J. , V. Nihart, J. D. D. Nihart, J. V. , Wilson W. B. 2 , C. D. Vulpe , C. D. , M. Kammueller and M. R. Fielden 2 1 1 F. Staedtler , F. 1 , A. Zaar , 1 , T. Takamura-Enya T. , 3 , L. Yoo , L. 1 , R. Papoian 1 , H. H. Schmeiser 1 Novartis, East Hannover, NJ. East Hannover, Novartis, Institute of Cancer Research, Sutton, Surrey, Nutritional Sciences and Toxicology, UC-Berkeley, UC-Berkeley, Toxicology, Nutritional Sciences and Institute, Tokyo, Japan. Sponsor: Tokyo, Institute, Heidelberg, Germany, Germany, Heidelberg, F. Dieterle F. LIMITED ADDITIONAL RELEASE ADDITIONAL LIMITED T IN AND I TROPONINS OF CARDIAC DOGS BEAGLE TREATED ISOPROTERENOL INJURY. WITH CARDIAC D. E. Arrieta E. and D. A. Ramirez Henderson, CA and Berkeley, M. Denison OF PRE-CLINICAL SAFETY BIOMARKERS. Hillenbrand Mahl 2 Arlt 1 United Kingdom, Osaka, Japan and RESEARCH. 1 Wintz Wahl D. T. Yagi T. Environmental Toxicology, University of California, University Toxicology, Environmental CA. Davis, OF BIOMARKERS IDENTIFICATION MINNOW FATHEAD FOR EXPOSURE OF USING CDNA 4-DINITROTOLUENE 2, TO WITH - CORRELATION MICROARRAYS IN MAMMALS. CLINICAL SYMPTOMS Basel, Switzerland and Novartis, Development, Herlich J. Sansone, M. Kemmerer, Hall, S. Bryant, J. Raritan, NJ. Lord. Johnson & Johnson PRD, and P. THREE MAJOR OF IDENTIFICATION THE ADDUCTS FORMED BY DNA 3- AIR POLLUTANT CARCINOGENIC AT LUNG IN RAT NITROBENZANTHRONE N2 POSITION OF GUANINE AND THE C8 V. ADENINE. OF THE N6 POSITION AT AND MONITORING CHOLINESTERASES: CHOLINESTERASES: MONITORING TRANSLATIONAL AN EXAMPLE OF SEARCH FOR CANDIDATE PROTEIN PROTEIN SEARCH FOR CANDIDATE TOXICITIES. BIOMARKERS FOR PBDES , H. Pyo, E. Kim, H. Ku, H. Kang, S. Son E. Kim, H. Ku, , H. Pyo, S. Jeong Anyang, NVRQS, Division, Toxicology Cho. and J. South Korea. Kyunggi, E. J. Perkins E. J. M. DeCristofaro View, CA. View, VALIDATION THE TOWARDS A FIRST STEP Development Center, Vicksburg, MS. Vicksburg, Center, Development ARYL AND CYP1A1 INDUCTION ACTIVATION: RECEPTOR HYDROCARBON FOR PRE-CLINICAL PENALTY DEATH C. Sorrentino CANDIDATE? DRUG Environmental Toxicology, University of California, University Toxicology, Environmental CA and Davis,
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S. Chen College of College 1 . 1 UGT1A1 . Iconix T. Zacharewski and T. Pharmacy, University of University Pharmacy, 2 C. M. Vezina , C. M. 1 A. K. Lund and 2 , M. Yueh, Yueh, A. Bonzo, M. J. , L. Burgoon and R. Brennan B. J. Ovando J. B. , G. Fink 1 Pharmacology and Toxicology, Michigan Michigan Toxicology, and Pharmacology 2 Pharmacology & Toxicology, University at University Toxicology, & Pharmacology 1 . , E. Dere 1
Biochemistry & Molecular Biology, Center for Biochemistry & Molecular Biology, Safety & and National Food Toxicology, Integrative East State University, Michigan Center, Toxicology BY A NON-CLASSICAL Ah RECEPTOR Ah RECEPTOR A NON-CLASSICAL BY VALIDATION OF PUTATIVE BIOMARKERS OF PUTATIVE VALIDATION PREDICTION OF NON- THE EARLY FOR HEPATOCARCINOGENESIS GENOTOXIC SIGNATURES. DRUG TO AND COMPARISON Lansing, MI. ARYL THE FOR A NEW ROLE IN RECEPTOR HYDROCARBON A. J. GENE EXPRESSION. REGULATING Health, . Env. Tomlinson and C. R. Schwanekamp of Cincinnati, Cincinnati, OH. University Pharmacy, University of New Mexico, Albuquerque, Albuquerque, Mexico, of New University Pharmacy, Olson NM and CHRYSIN INDUCES HUMAN INDUCES HUMAN CHRYSIN MECHANISM. . Laboratory of Environmental Tukey and R. H. Departments and of Pharmacology Toxicology, of California University Chemistry & Biochemistry, La Jolla, CA. San Diego, RECEPTOR HYDROCARBON ARYL THE THE OXYGEN- (AHR) INFLUENCES OF ENDOTHELIN-1 REGULATION THE AND MODULATES EXPRESSION HYPERTENSION. DEVELOPMENT OF DOWN-REGULATION IN HEPATIC GENE GENE IN HEPATIC DOWN-REGULATION WITHIN 6H OF EXPOSURE EXPRESSION TCDD. TO K. Walker K. M. R. Fielden CA. View, Pharmaceuticals, Mountain J. Burt J. Buffalo, Buffalo, NY and Buffalo, Buffalo, Wisconsin, Madison, WI. Madison, Wisconsin, TCDD- OF ANALYSIS GENOME-WIDE OF BINDING PROMOTER MEDIATED RECEPTOR. HYDROCARBON ARYL THE State University, East Lansing, MI. State University, OF GENE EXPRESSION PROFILE ANALYSIS EPITHELIAL CELLS IN BRONCHIAL DIESEL EXHAUST TO IN RESPONSE EXPOSURE USING CDNA PARTICLES Diaz-Sanchez. CIA, and D. Wan J. MICROARRAY. Whitekus Angeles, CA. Sponsor: M. UCLA, Los 45th Annual Meeting and ToxExpo and Meeting Annual 45th
: Barry Wilson, University of California Davis, Davis, CA Davis, of California University Wilson, Chairperson(s): Barry South Korea. Kyunggi, Anyang, NVRQS, and Sang-Hee Jeong, #784 9:00 Room 15A AND IDENTIFICATION BIOMARKERS: SESSION: PLATFORM APPLICATION #783 11:40 7 March Tuesday, 12:00 NOON AM to 9:00 #779 10:20 #778 10:00
#781 11:00 Program Description Description Program #782 11:20 #780 10:40
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 #798 11:00 ACUTE TOXICITY OF ACETALDEHYDE 9:00 AM to 12:00 NOON ON ALDEHYDE DEHYDROGENASE 2 Room 6F GENE TARGETING MICE: 5000PPM 4H INHALATION STUDY. T. Isse1, T. Oyama1, 2 3 1 1 PLATFORM SESSION: GENETIC POLYMORPHISMS K. Naoki , K. Matsuno , M. Ogawa , T. Kinaga , T. Murakami1, T. Yamaguchi1, K. Kitagawa4, I. Chairperson(s): Sherif Abdel-Rahmen, University of Medicine and Uchiyama5 and T. Kawamoto1. 1Environmental Dentistry of New Jersey, Newark, NJ and Andrew Smith, University of Health, University of Occupational and Leicester, Leicester, United Kingdom. Environmental Health, Kitakyushu, Japan, 2Health Science, University of Occupational #792 9:00 GENETIC POLYMORPHISMS OF HUMAN and Environmental Health, Kitakyushu, Japan, N-ACETYLTRANSFERASE 2 INFLUENCE 3Bio-information Research Center, University THE BIOACTIVATION OF AROMATIC AND of Occupational and Environmental Health, HETEROCYCLIC AMINES. Y. Zang, M. A. Kitakyushu, Japan, 4First Department of Doll, J. States and D. W. Hein. Pharmacology & Biochemistry, University of Occupational and Toxicology and Brown Cancer Center, University of Environmental Health, Hamamatsu, Japan and Louisville, Louisville, KY. 5Environmental Hygiene, School of Technology, #793 9:20 N-ACETYLTRANSFERASE 2 (NAT2) Kyoto University, Kyoto, Japan. GENOTYPE DEPENDENT METABOLIC #799 11:20 CHINESE HAMSTER OVARY CELLS ACTIVATION OF N-HYDROXY ARYLAMINE EXPRESSING CYP1A1 OR CYP1A2 AND CARCINOGENS IN CRYOPRESERVED RAPID OR SLOW ACETYLATOR N- HUMAN HEPATOCYTES. M. A. Doll1, N. 2 1 1 ACETYLTRANSFERASE 1 (NAT1): A MODEL S. Jensen and D. W. Hein . Pharmacology & TO INVESTIGATE EFFECTS OF HUMAN Toxicology and Brown Cancer Center, University 2 NAT1 POLYMORPHISM ON ARYLAMINE of Louisville, Louisville, KY and In Vitro GENOTOXICITY. J. Bendaly, S. Zhao, M. A. Technologies, Baltimore, MD. Doll, J. States and D. W. Hein. Pharmacology & #794 9:40 QUANTIFICATION OF 4-AMINOBIPHENYL Toxicology and Brown Cancer Center, University of DNA ADDUCTS IN RAPID AND SLOW Louisville, Louisville, KY. ACETYLATOR RATS BY LIQUID #800 11:40 2-AMINO-1-METHYL-6-PHENYLIMIDAZO CHROMATOGRAPHY-TANDEM MASS [4, 5-B] PYRIDINE (PHIP)-INDUCED SPECTROMETRY. J. R. Neale, N. B. Smith, W. M. DNA ADDUCTS IN CHINESE HAMSTER Pierce and D. W. Hein. Pharmacology & Toxicology OVARY (CHO) CELLS EXPRESSING and Brown Cancer Center, University of Louisville, HUMAN CYP1A2 AND RAPID AND SLOW Louisville, KY. N-ACETYLTRANSFERASE 2 (NAT2). K. J. #795 10:00 DETERMINATION OF THE SENSITIVITY Metry, S. Zhao, J. R. Neale, M. A. Doll, J. States, OF CURRENT MUTATION DETECTION W. McGregor, W. M. Pierce and D. W. Hein. METHODOLOGIES THROUGH THE Pharmacology & Toxicology and Brown Cancer USE OF THE NIST HETEROPLASMIC Center, University of Louisville, Louisville, KY. MITOCHONDRIAL DNA STANDARD REFERENCE MATERIAL 2394. B. C. Levin. Tuesday, March 7 Biotechnology Division, National Institute of 9:00 AM to 12:00 NOON Standards and Technology, Gaithersburg, MD. Room 7A #796 10:20 NORMAL LIVER AND SPLEEN IRON STATUS PLATFORM SESSION: IN VITRO AND IN VIVO RESPONSES TO ARE UNDER MULTIGENIC CONTROL. A. G. SMOKE Smith1, G. R. Grant1, S. Robinson1, R. E. Edwards1, 1 1 2 1 R. Davies , D. J. Judah and K. W. Broman . MRC Chairperson(s): Laura Van Winkle, University of California Davis, Davis, Toxicology Unit, University of Leicester, Leicester, CA and Judith Zelikoff, New York University School of Medicine, Tuxedo, TUESDAY 2 United Kingdom and Department of Biostatistics, NY. Johns Hopkins Medical School, Baltimore, MD. #801 9:00 MODULATION OF GAS-VAPOR PHASE- #797 10:40 A PHARMACOGENOMIC APPROACH FOR INDUCED CYTOTOXICITY FROM 2R4F ANTICOAGULATION THERAPY: EFFECT OF KENTUCKY REFERENCE CIGARETTE. POLYMORPHISMS IN THE MICROSOMAL J. T. Hamm and J. D. Johnson. Lorillard Tobacco EPOXIDE HYDROLASE (MEH) GENE ON Company, Greensboro, NC. WARFARIN-DOSE REQUIREMENT AND METABOLISM. C. Kinslow, M. M. Xue, H. #802 9:25 IMPAIRMENT OF LUNG CELL ENERGETICS vonMarrensdorff, C. Lee, C. C. Hallberg, C. E. Hill, BY TETRAHYDROCANNABINOL IN VIVO. T. 1 1 2 1 K. J. Wolfe and S. Abdel-Rahman. UTMB, Galveston, A. Sarafian , L. Lin , M. Oldham , D. P. Tashkin and 1 1 TX. M. D. Roth . Medicine, UCLA, Los Angeles, CA and 2Community and Environmental Medicine, UC Irvine, Irvine, CA.
up-to-date information at www.toxicology.org 123
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D. D. R. E. , J. B. B. , J. , C. P. , C. P. 1 , T. R. T. , C. T. Jung T. , C. AN-EX, 1 1 , K. Brain 2 1 CDER/Office and D. P. P. and D. 2 2 Center for 1 , Z. A. Filip , Z. , H. Beasley 1 . 1 2 EHSA, Celanese. A. Api , A. J. E. Riviere and J. 1 1 , D. L. Macalady , D. 1 R. Gehring . Annual Meeting Annual 2 Charles River Charles River , , A. V. Valles V. A. , D. B. Learn B. D. 2 th J. J. Yourick J. J. 1 Chemical Engineering, 2 , T. Coston T. , 1 CFSAN/Office of Cosmetics J. B. Ulreich B. J. Haskell Laboratory, E. I. Du Laboratory, Haskell , J. Lalko , J. , P. M. Goldfarb , P. 1 2 1 2 . 1 Chemistry, Colorado School of Colorado Chemistry, 1 , J. M. McMahon M. , J. M. L. Jovanovic A. M. Hoberman . SOT's 45 SOT's 2 Research Institute for Fragrance 1 J. D. Brooks D. , J. . 2 and Surgery, University Arizona, Tucson, AZ Tucson, Arizona, University Surgery, . 1 W. J. Fasano J. and W. , M. J. Demeure , M. J. 1 S. Bhatia 1 1 . , M. Arocena , M. , N. B. Dev B. , N. 2 1 1 N. A. Monteiro-Riviere , N. Inovio Biomedical Corp., CA. San Diego, Inovio 2 and Colors, USFDA, Laurel, MD and and Colors, USFDA, Ltd., Dallas, TX and Ltd., Dallas, Rabussay DERMAL ABSORPTION RATE ABSORPTION RATE DERMAL VITRO IN TESTING OF METHYL FORMATE. and Laboratories Preclinical Charles River Photobiology, and Services, Horsham, PA Raleigh, NC. OF HUMAN SKIN PENETRATION IN-VITRO GERANYL MATERIAL THE FRAGRANCE NITRILE. MEMBRANES. S. E. Deglin Mines, Golden, CO and PORCINE MODEL. Ledesma PERCUTANEOUS ABSORPTION OF ABSORPTION PERCUTANEOUS AND VIVO (IN RAT RETINOL IN FUZZY ) FROM VITRO IN AND HUMAN SKIN ( ) VITRO VEHICLES. COSMETIC and R. L. Bronaugh FRANZ CELLS. Corning Corporation, Crofoot. Dow and S. D. MI. Midland, BASED A PHYSIOLOGICALLY MODEL OF PHARMACOKINETIC ABSORPTION. DERMAL PARATHION Baynes van der Merwe NJ and Lake, Woodcliff Materials Inc., Barfknecht of Generic Drugs, USFDA, Rockville, MD. of Generic Drugs, USFDA, AN AS PERMEABILITY WATER TRITIATED OF INTEGRITY BARRIER OF INDICATOR IN AND PIG SKIN USED HUMAN VITRO IN Sambuco Pont de Nrmours and Company, Newark, DE. Newark, de Nrmours and Company, Pont ALCOHOL CONSUPTION ON OF IMPACT AS DETERMINED BY NON- THE SKIN TOOLS. BIOENGINEERING INVASIVE and D. Green and D. , J. L. Jendrzejewski and A. R. Charron. and L. Jendrzejewski , J. Brand Northwestern Department of Medicine, Evanston IL. Healthcare Research Institute, Evanston, HEALING FOLLOWING WOUND A THERAPY IN ELECTROPORATION Forbes D. P. COMPARATIVE SENSITIVITY OF TWO TWO SENSITIVITY OF COMPARATIVE ASSAYING METHODS FOR VIVO IN AGENTS. PHOTOTOXIC Center for Chemical Toxicology Research and Toxicology Center for Chemical Pharmacokinetics, North Carolina State University, A. L. Bunge and Laboratories, Horsham, PA. Cardiff, United Kingdom. Cardiff, CONTAMINATED ABSORPTION FROM AND SILICONE RUBBER SKIN SOIL INTO Speer P. D. Colorado School of Mines, Golden, CO. Sponsor: Colorado School of Mines, Golden, CO. M. Dellarco
(Continued) Annual Annual th #815 #813 #810 #812 #811 #816 #817 #818 #814 45 124 . 3 Meeting & ToxExpo & Meeting
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, N. Ferrari , N. 1 and D. Horohov and D. K. E. Pinkerton 2 S. Flack , R. Rouse 1 . SCIREQ Scientific G. L. Baker L. , G. 1 1 . 2 Vet. Sciences, University of Sciences, University Vet. 3 A. Penn L. A. Nylander-French and L. 1 , M. Kearney 2 and B. C. Edwards. C. Edwards. Hughes and B. M. F. VM:APC/CHE, UC Davis, Davis, CA Davis, VM:APC/CHE, UC Davis, 1 . 1 L. M. Ball and L. Paquet . L. S. Van Winkle Van L. S. 2 North Carolina A&T State University, A&T State University, North Carolina , , L. Lomax 2 2 2 Topigen Pharmaceuticals Inc., Montréal, QC, Topigen Battelle, Richland, WA. Battelle, Richland, 2 2
Environmental Sciences & Engineering, University Sciences & Engineering, University Environmental Pathobiol. Sciences., LSU School of Vet. Med., Vet. of Sciences., LSU School Pathobiol. CBS, LSU School of Vet. Med., Baton Rouge, LA, Med., Baton Rouge, Vet. CBS, LSU School of Paulsen M. Fortin ORD/NHEERL, U.S. EPA, Research Triangle Park, Park, Triangle Research EPA, ORD/NHEERL, U.S. SHORT-TERM CIGARETTE SMOKE SHORT-TERM ENDOTOXIN- EXPOSURE POTENTIATES INFLAMMATION. INDUCED PULMONARY NC. Goktepe 1 of North Carolina at Chapel Hill, Chapel Hill, NC and Greensboro, NC. ABSORPTION OF DERMAL VITRO IN AND PESTICIDES IN RAT PYRETHROID HUMAN SKIN. DERMAL EXPOSURE TO PROPICONAZOLE PROPICONAZOLE TO DERMAL EXPOSURE WORKERS. AMONG FARM CIGARETTE SMOKE-INDUCED LUNG Schuessler F. T. INFLAMMATION. Respiratory Equipment Inc., Montréal, QC, Canada and Bhalla Canada. Sponsor: D. 1 2 Baton Rouge, LA and PEROXIREDOXIN-6 IS DECREASED IN PEROXIREDOXIN-6 MOUSE ADULT AND FEMALE MALE BOTH TOBACCO TO BY EXPOSURE AIRWAYS SMOKE. Sutherland and GENDER AND STRAIN DIFFERENCES GENDER SMOKE-INDUCED TOBACCO IN Shen and Y. INFLAMMATION. Center for Health and the Environment, University University Center for Health and the Environment, CA. Davis, of California, Davis, G. S. Kulkarni, P. P. Nadkarni, J. M. Cerreta and J. M. Cerreta and J. Nadkarni, J. P. P. G. S. Kulkarni, Allied Health Professions, Pharmacy and Cantor. O. Sponsor: York. New University, St John’s Trombetta KY, Lexington, KY. Lexington, KY, ON EFFECT OF EXPOSURE PATTERN EXPOSURE TO ENVIRONMENTAL ENVIRONMENTAL TO EXPOSURE UTERO IN SMOKE (ETS) CAN POTENTIATE TOBACCO TO TOLERIZATION OR SENSITIZATION AEROALLERGEN. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#806 11:05 #809 9:00 AM–10:30 AM AM–10:30 Attended: 9:00 #808 Exhibit Hall DERMATOTOXICITY POSTER SESSION: NC Raleigh, State University, North Carolina Chairperson(s): Jim Riviere, NJ. Brunswick, New University, Rutgers White, Lori AM–12:00 NOON 9:00 Displayed: 9:00 AM to 12:00 NOON 9:00 #803 9:50 #807 11:30
Tuesday, March 7 March Tuesday, Program Description Description Program #805 10:40 #804 10:15
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #819 QUANTITATIVE AND TEMPORAL #826 FULLERENE-BASED AMINO ACID (BAA) DIFFERENCES IN UVR DOSE-DEPENDENT INTERACTIONS IN HUMAN EPIDERMAL SKIN RESPONSES IN RODENTS (MICE, KERATINOCYTES. J. G. Rouse1, A. R. RATS AND GUINEA PIGS). C. P. Sambuco1, P. Barron2, J. Yang2 and N. A. Monteiro-Riviere1. D. Forbes1, D. B. Learn1, M. Arocena1, T. Coston1, 1Center for Chemical Toxicology Research and H. Beasley1 and A. M. Hoberman2. 1Center for Pharmacokinetics, North Carolina State University, Photobiology, Charles River Laboratories Preclinical Raleigh, NC and 2Department of Chemistry and Services, Horsham, PA and 2Charles River Center for Nanoscale Science and Technology, Rice Laboratories Preclinical Services, Horsham, PA. University, Houston, TX. #820 ETIOLOGY OF 8-METHOXYPSORALEN #827 SKIN PENETRATION OF FULLERENE PHOTOTOXICITY IN MOUSE SKIN IS SUBSTITUTED AMINO ACIDS AND THEIR DEPENDENT ON VEHICLE, EXPOSURE INTERACTIONS WITH HUMAN EPIDERMAL TIME AND ADMINISTRATION SITE. KERATINOCYTES. N. A. Monteiro-Riviere1, J. G. L. DeGeorge. MB Research Laboratories, Yang2, A. O. Inman1, J. Ryman-Rasmussen1, A. R. Spinnerstown, PA. Barron2 and J. E. Riviere1. 1Center for Chemical Toxicology Research and Pharmacokinetics, #821 MORPHOLOGICAL CORRELATES OF North Carolina State University, Raleigh, NC and PLATELET ACTIVATING FACTOR -INDUCED 2Department of Chemistry and Center for Nanoscale DEGRANULATION OF ISOLATED MAST Science and Technology, Rice University, Houston, 2 2 CELLS. C. M. wessely , J. P. petrali , A. A. TX. Brimfield1 and H. A. tracey2. 1pharmacology branch, USAMRICD, APG/EA, MD and 2comparitive #828 SKIN PENETRATION, CELLULAR UPTAKE, Medicine division, USAMRICD, APG/EA, MD. CYTOTOXICITY, AND INFLAMMATORY POTENTIAL OF QUANTUM DOTS. J. P. Ryman- #822 EXTRACTION PROCEDURE OF TATTOO Rasmussen, J. E. Riviere and N. A. Monteiro-Riviere. 2 PIGMENTS FROM SKIN. E. Engel , W. Center for Chemical Toxicology Research and 1 1 1 2 Baumler , T. Maisch , H. Ulrich , B. Konig , M. Pharmacokinetics, North Carolina State University, 1 3 3 Landthaler , N. V. Gopee , P. C. Howard and R. Raleigh, NC. Vasold2. 1Dermatology, University of Regensburg, Regensburg, Germany, 2Organic Chemistry, #829 POLYMER STANDARDS FOR University of Regensburg, Regensburg, Germany QUANTITATION OF QUANTUM DOTS IN and 3Biochemical Toxicology, NCTR, Jefferson, AR. TISSUE. D. W. Roberts1, N. V. Gopee1, A. R. Warbritton2, W. W. Yu4, V. L. Colvin4, N. J. Walker3 #823 TRACE ANALYSIS OF NANO-C IN 1 1 60 and P. C. Howard . Biochemical Toxicology, NCTR, BIOLOGICAL MEDIA BY LIQUID-LIQUID Jefferson, AR, 2Toxicological Pathology Associates, EXTRACTION AND HIGH-PERFORMANCE Jefferson, AR, 3National Toxicology Program, 1 LIQUID CHROMATOGRAPHY. X. R. Xia , N. NIEHS, Research Triangle Park, NC and 4Rice 1 2 2 A. Monteiro-Riviere , C. M. Sayes , V. L. Colvin University, Houston, TX. and J. E. Riviere1. 1Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina #830 INTERACTION OF NANOMATERIALS WITH State University, Raleigh, NC and 2Department MOUSE KERATINOCYTES. C. Amato3, S. of Chemistry & Center for Biological and Hussain1, K. Hess2 and J. Schlager1. 1Air Force Environmental Nanotechnology, Rice University, Research Laboratory, Mantech Environment, Houston, TX. Wright-Patterson AFB, OH, 2Geo-Center Inc., Wright-Patterson AFB, OH and 3Oak Ridge Institute #824 MULTI-WALLED CARBON NANOTUBE for Science and Education, Oak Ridge, OH. EXPOSURE IN HUMAN KERATINOCYTES ALTERS PROTEIN EXPRESSION. F. #831 PARAQUAT ALTERS EXPRESSION OF Witzmann1, D. Hong1, A. O. Inman2, J. E. Riviere2, ARACHIDONIC ACID METABOLIZING 3 3 R. J. Neimanich , Y. Wang and N. A. Monteiro- ENZYMES AND HEME OXYGENASE- TUESDAY Riviere2. 1Cellular & Integrative Physiology, Indiana 1 (HO-1) IN PRIMARY CULTURES OF University School of Medicine, Indianapolis, IN, MOUSE KERATINOCYTES. A. T. Black1, 2Center for Chemical Toxicology Research and M. P. Shakarjian3, J. P. Gray2, V. Mishin2, M. Pharmacokinetics, North Carolina State University, Thiruchelvam4, D. A. Cory-Slechta4, D. E. Heck1, 2 Raleigh, NC and 3Department of Physics, North and J. D. Laskin1, 4. 1Toxicology, Rutgers University, Carolina State University, Raleigh, NC. Piscataway, NJ, 2Pharmacology-Toxicology, Rutgers University, Piscataway, NJ, 3Medicine, UMDNJ- #825 NANOC AND DERIVATIZED C TOXICITY 4 60 60 RWJMS, Piscataway, NJ and Environment & IN HUMAN EPIDERMAL KERATINOCYTES. Occupation Med., UMDNJ-RWJMS, Piscataway, NJ. A. O. Inman1, C. M. Sayes2, V. L. Colvin2 and N. A. Monteiro-Riviere1. 1Center for Chemical Toxicology #832 2, 3, 7, 8-TETRACHLORODIBENZO-p-DIOXIN Research and Pharmacokinetics, North Carolina INDUCED MATRIX METALLOPROTEINASE State University, Raleigh, NC and 2Department EXPRESSION IN A2058 MELANOMA CELLS. of Chemistry & Center for Biological and K. A. Murphy and L. A. White. Joint Graduate Environmental Nanotechnology, Rice University, Program of the Molecular Biosciences, Joint Houston, TX. Graduate Program in Biochemistry, Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ. up-to-date information at www.toxicology.org 125 1, , 1
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Alion, Wright-Patterson AFB, OH and AFB, Wright-Patterson Alion, , B. M. Barlow, J. L. Yeatts Yeatts L. J. M. Barlow, X. R. Xia, B. 2 A. R. Murray , , A. J. Guilfoil A. J. , , A. Bricarello , , H. La 1 1 X. Xia 1 , P. Josset , P. J. J. Schlager J. and J. , 2 3 Safety Assessment, Genentech, Inc., South San Assessment, Genentech, Inc., South San Safety , C. Kommineni Virginia West and Pharmacology, Physiology de Hospital, Fort University Ophthalmology, ORISE, Oak Ridge, TN. ORISE, Oak Ridge, ANTIOXIDANT DEFENSE AND TOXIC TOXIC AND DEFENSE ANTIOXIDANT CHEMICALS EFFECTS OF OCCUPATIONAL SKIN. TO Francisco, CA and Francisco, WV and Morgantown, University, Martinique, France, France, AFB, OH, AFB, OF SELECTIVE BEHAVIOR PARTITIONING JET FUEL ALIPHATIC AND AROMATIC MEMBRANES. ACROSS COMPONENTS Riviere E. Choo 1 2 1 Gerard 2 (ORTYCTOLAGUS WHITE RABBITS (ORTYCTOLAGUS CUNICULI). S. C. Stevens Minnick Amato 3 E. Baynes Toxicology . Center for Chemical E. Riviere and J. Research and Pharmacokinetics, North Carolina Raleigh, NC. State University, MEMBRANE-COATED MULTIPLE INERT ABSORPTION FIBERS PREDICT DERMAL MIXTURES. OF CHEMICALS FROM . Center for Chemical Toxicology Research Toxicology . Center for Chemical Riviere and Pharmacokinetics, North Carolina State Raleigh, NC. University, HEDGEHOG TOPICAL A EFFECTS OF ON NORMAL SKIN. ANTAGONIST S. X. Shen and G. R. I. Stewart, A. Seawright, A. National Research Centre for Environmental Shaw. Brisbane, of Queensland, The University Toxiclogy, Australia. Sponsor: QLD, Flagella EVALUATION OF SKIN BARRIER CREAMS BARRIER OF SKIN EVALUATION IN NEW ZEALAND JP-8 IRRITATION TO Trousseau Hospital, Paris, France and France Hospital, Paris, Trousseau Spencerville, OH. THE OF TOXICITY DERMAL CYANOBACTERIUM TROPICAL RACIBORSKII. CYLINDROSPERMOPSIS France, Talence, laboratory, Researches, PREVOR Morgantown, WV. Morgantown, FOR OF DIPHOTERINE EVALUATION THE AT ALKALI BURNS RINSING OF HOSPITAL. WY. Mountain,
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Meeting & ToxExpo & Meeting . , and 1, 2 3 , . 1 J. J. S. 1 M. Singh DIOXIN -p-DIOXIN D. Kim . D. , B. J. Miller J. , B. 1 W. G. Wamer G. , W. 1 B. Allen- and B. 1 , H. Fang 1 , V. G. Desai V. , 1, 2 CFSAN, USFDA, College Park, Park, College USFDA, CFSAN, 3 NCTR, USFDA, Jefferson, AR, Jefferson, NCTR, USFDA, 1 L. A. Nylander-French and L. . 2 Molecular and Environmental Molecular and Environmental 1 1, 2 , W. Tong W. , . 1 1, 2 N. V. Gopee V. N. CIIT Centers for Health Research, Research Pathology and Laboratory Medicine, University and Laboratory Medicine, University Pathology 2 2 Environmental Sciences & Engineering, University Sciences & Engineering, University Environmental NTP Center for Phototoxicology, NCTR, USFDA, NCTR, USFDA, NTP Center for Phototoxicology, Toxicology, University of Wisconsin, Madison, WI Madison, Wisconsin, of University Toxicology, , E. Ahaghotu and , E. Babu FULZELE, R. J. of North Carolina at Chapel Hill, Chapel Hill, NC and PERMEABILITY COEFFICIENTS OF JET VIVO FUEL COMPONENTS IN 1 CHANGES IN GENE EXPRESSION IN AFTER JET FUEL (JP- EPIDERMIS RAT Amato, C. M. SKIN. THE TO 8) EXPOSURE . Department McDougal N. C. M. Garrett and J. Wright State Toxicology, and of Pharmacology OH. Dayton, University, TIME COURSE OF JP-8 JET FUEL THE EPIDERMIS IN CONCENTRATION AFTER AND DERMIS OF FISHER RATS EXPOSURES. C. M. Garrett and CUTANEOUS . Department McDougal and of Pharmacology N. J. OH. Dayton, Wright State University, Toxicology, OF HUMAN SKIN ESTIMATION MICE. 2 AR and Jefferson, and 2, 3, 7, 8-TETRACHLORODIBENZO 7, 3, 2, . BiochemistryWhite and Microbiology, and L. New Jersey, of New The State University Rutgers, Brunswick, NJ. AND EFFECTS OF EXOGENOUS ON ACTIVATION AHR ENDOGENOUS AND CELL FATE GENES CONTROLLING EPIDERMAL HUMAN IN DIFFERENTIATION Pay Van TYPES. L. M. CELL and C. M. Garrett. McDougal DepartmentN. Wright State Toxicology, and of Pharmacology OH. Dayton, University, OF REAL-TIME PCR CONFIRMATION MD. AFTER SKIN GENE EXPRESSION IN RAT JP- TO EXPOSURE BRIEF CUTANEOUS AND FOUR COMPONENTS OF JP-8. 8 Hoffmann College of Pharmacy, Florida A&M University, A&M University, Florida of Pharmacy, College FL. Tallahassee, Triangle Park, NC. Park, Triangle OF DERMAL MICRODIALYSIS NEUROCHEMICALS PROINFLAMMATORY AFTER AS MARKERS OF SKIN IRRITATION WITH JP-8 CHEMICALS. EXPOSURE of Wisconsin, Madison, WI. Madison, Wisconsin, of IN GENE EXPRESSION PROFILES SKIN OF SKH-1 HAIRLESS TATTOOED INHIBITS EXPRESSION OF THE INHIBITOR THE INHIBITOR OF INHIBITS EXPRESSION AND -3 IN NORMAL BINDING (ID) -1 OF DNA Villano C. Akintobi, A. HUMAN FIBROBLASTS. M. E. Andersen M. E. P. C. Howard P. J. C. Fuscoe J. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#836 Program Description Description Program #840 #835
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 #855 EXPOSURE TO NATURALLY OCCURRING 9:00 AM to 12:00 NOON ASBESTOS DURING OFFROAD VEHICLE Exhibit Hall AND CAMPING/HIKING ACTIVITIES AT A RECREATIONAL AREA IN CALIFORNIA. D. POSTER SESSION: EPIDEMIOLOGY/EXPOSURE ASSESSMENT Stralka, L. Suer and A. Den. Region 9, U.S. EPA, San Francisco, CA. Sponsor: G. Hiatt. Chairperson(s): Janice Chambers, Mississippi State University, #856 Mississippi State, MS and Thomas Hesterberg, International Truck and PERSONAL EXPOSURES TO NATURALLY- Engine Corporation, Littleton, CO. OCCURRING ASBESTOS DURING SPORTS AND PLAY ACTIVITIES IN A CALIFORNIA Displayed: 9:00 AM–12:00 NOON COMMUNITY IN THE SIERRA FOOTHILLS. G. F. Hiatt, A. R. Den and J. M. Johnson. Region 9, Attended: 10:30 AM–12:00 NOON U.S. EPA, San Francisco, CA. #848 BERYLLIUM EXPOSURE AND THE #857 RETROSPECTIVE EXPOSURE ANALYSIS PREVALENCE OF CHRONIC BERYLLIUM OF RESIDENTIAL EXPOSURE TO DISEASE AND BERYLLIUM SENSITIZATION. PERFLUOROOCTANOIC ACID (PFOA) FROM E. Donovan1, A. Madl1, M. Kelsh2 and D. 1951 TO 2003. D. J. Paustenbach1, P. K. Scott2, K. Paustenbach1. 1ChemRisk, Inc., San Francisco, CA M. Unice2 and J. M. Panko2. 1ChemRisk, Inc., San and 2Exponent, Menlo Park, CA. Francisco, CA and 2ChemRisk, Inc., Pittsburgh, PA. #849 BERYLLIUM SENSITIZATION AND #858 NICKEL ABSORPTION FOLLOWING WATER CHRONIC BERYLLIUM DISEASE IN A INGESTION IN ADULTS: A PROBABILISTIC BERYLLIUM METAL MACHINING PLANT: APPROACH TO ESTIMATION OF NICKEL ANALYSIS OF BERYLLIUM EXPOSURE AND BIOAVAILABILITY. M. H. Follansbee, T. L. IMPLICATIONS FOR AN OCCUPATIONAL Negley, W. T. Thayer, P. E. Goodrum and G. L. EXPOSURE LIMIT. A. Madl1, K. Unice1, J. Diamond. Environmental Science Center, Syracuse Brown1, M. Kolanz2 and M. Kent2. 1ChemRisk, Research Corporation, Syracuse, NY. Inc., San Francisco, CA and 2Brush Wellman Inc., Cleveland, OH. #859 SURVEY OF RECREATIONAL ACTIVITIES ALONG KING COUNTY, WA SHORELINES #850 ANALYSIS OF EXPOSURE TO BENZENE FOR USE IN SITE-SPECIFIC RISK IN MINERAL SPIRIT SOLVENTS DURING ASSESSMENT: EXPOSURE DISTRIBUTIONS PARTS WASHING AND DEGREASING FOR SEDIMENT AND WATER CONTACT OPERATIONS. J. Greene, E. Goswami, P. Sheehan ACTIVITIES AND FISH CONSUMPTION. and J. Hicks. Exponent, Oakland, CA. D. B. Mayfield1, S. Robinson1 and J. Simmonds2. 1Parametrix, Inc., Bellevue, WA and 2Department of #851 RECONSTRUCTION OF BENZENE Natural Resources and Parks, King County, Seattle, EXPOSURES DURING THE SIMULATED WA. USE OF A PENETRATING AND DE-RUSTING AGENT. P. R. Williams1, J. Knutsen1 and D. J. #860 ESTIMATING SOURCE CONTRIBUTION Paustenbach2. 1ChemRisk, Boulder, CO and INSIDE SCHOOL BUSES. M. D. Easter1, R. 2ChemRisk, San Francisco, CA. Ireson2, L. Liu3, D. Lawson4, B. Zielinska5, J. Ondov6, C. Weaver7, M. Davey3, C. Lapin8 and T. #852 RECONSTRUCTION OF EXPOSURE OF Hesterberg9. 1EnSIGHT, Walnut Creek, CA, 2Air SKILLED CRAFTSMEN TO ASBESTOS AT Quality Management Consulting, Greenbrae, CA, THE BEAUMONT, TEXAS REFINERY (1946- 3University of Washington, Seattle, WA, 4National 2004). P. R. Williams1 and D. J. Paustenbach2. Renewable Energy Laboratory, Golden, CO., 1ChemRisk, Boulder, CO and 2ChemRisk, San 5Desert Research Institute, Reno, NV, 6University Francisco, CA. of Maryland, Baltimore, MD, 7Engine Fuel &
#853 ASSESSMENT OF ASBESTOS EXPOSURE Emissions Engineering, Inc., Rancho Cordova, TUESDAY AMONG AUTOMECHANICS SERVICING CA, 8Lapin & Associates, Los Angeles, CA and AND HANDLING ASBESTOS CONTAINING 9International Truck and Engine Corp., Chicago, IL. GASKETS. C. L. Blake2, G. Dotson1 and R. D. #861 Harbison1. 1Environmental and Occupational PYRETHROIDS EXPOSURE IN THE Health, USF-COPH, Tampa, FL and 2Clayton Group CANADIAN POPULATION: A CASE STUDY M. C. Fortin1, M. Bouchard2, 1 Services, Kennesaw, GA. IN MONTRéAL. and G. Carrier1. 1Environmental and Occupational #854 CHARACTERIZATION OF CHRYSOTILE Health, Universite de Montréal, Montréal, QC, ASBESTOS EXPOSURES FOR GARAGE Canada and 2Institut national de sante publique du MECHANICS. J. Pierce1, F. Mowat2 and B. Quebec, Montréal, QC, Canada. L. Finley1. 1ChemRisk, San Francisco, CA and 2Exponent, Menlo Park, CA.
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1 , R. 1, 2, , C. Penn , M. 4 2, 1 Consultants 1 Department . 3 2 Department S. Ejaz 1 . 1, 2, 3 . T. Kawamoto T. Annual Meeting Annual D. M. Byrd , D. th , M. Bouchard 1, 2, 3 Environmental and Environmental 1 and H. Anundi. and H. Sahlberg B. Institut National de Santé 1 2 C. Lim . Toxicology Consultants, Inc., Toxicology 1 2 and M. Feinleib 3 Midwest Research Institute, Midwest Johns Hopkins University- and C. Lim 1 2 . SOT's 45 SOT's , T. Kinaga, M. Ogawa, M. Ogawa, Kinaga, T. Isse, , T. 2 1, 2, 3 S. H. Lamm , R. Chen 1 , J. F. Taylor, B. Dash and B. Taylor, F. Afriyie-Gyawu, J. , E. G. Carrier and G. 3 Georgetown University Graduate School Graduate School University Georgetown 3 , I. Chekarova Chonbuk National Department of Pathology, Health and Safety Department, Hydro-Quebec, Consultants in Toxicology, Risk Assessment, and Risk Toxicology, Consultants in EXACERBATION OF VIRAL HEPATITIS VIRAL HEPATITIS OF EXACERBATION TO -IN RELATION WORKPLACES IN University, Jeonju, South Korea and Jeonju, South Korea University, in Epidemiology and Occupational Health, LLC., in Epidemiology DC, Washington, Product Safety, McLean, VA. McLean, Product Safety, TWO OF EVALUATION COMPARATIVE THE DETERMINATION FOR APPROACHES AND SELENIUM OF METHYLMERCURY FOOD FREQUENCY STATUS: TOXICOKINETIC AND QUESTIONNAIRE COMMERCIAL CIGARETTES. 3 2 N. Noisel MODELING. N. Plante Montréal, QC, Canada, 3 Montréal, QC, Canada. A NONINVASIVE DEVELOPMENT OF TO ASSAY BASED IMMUNOAFFINITY TO EXPOSED PRESCREEN POPULATIONS A. Malek, H. J. N. AFLATOXINS. DIETARY Huebner H. Butala and J. EXPOSURE OF DIFFERENT MAINSTREAM WHOLE SMOKE SOLUTIONS OF CHEMICAL EXPOSURE-. Oyama Narai, T. CANCERS. A. Engel 4 of Pathology, Biosafety Research Institute, of Pathology, Jeonju, South Korea, Chonbuk National University, Publique du Quebec, Montréal, QC, Canada and Publique Occupational Health, Universite de Montréal, de Montréal, Occupational Health, Universite Texas Medicine, Veterinary of Phillips. College D. T. TX. Station, College A&M University, NITROUS TO EXPOSURE OCCUPATIONAL AND SEVOFLURANE ISOFLURANE, OXIDE, ENKöPINGS AT THEATRES IN OPERATING SWEDEN. HOSPITAL Department of Occupational and Environmental Medicine, Uppsala, Sweden. MATERIAL CLOTHING PROTECTIVE Hooton D. CREOSOTE. TO PERMEABILITY T. Yamaguchi, T. Murakami and Y. Yashima. Yashima. Y. Murakami and T. Yamaguchi, T. Health, University Department of Environmental Health, of Occupational and Environmental Japan. Kitakyushu, THAT SUGGEST DATA EPIDEMIOLOGICAL THRESHOLD FOR HUMAN A ARSENIC HAS Bloomberg School of Public Health, Baltimore, School of Public Bloomberg MD, and School of Medicine, Washington, DC and DC Washington, and School of Medicine, MO and Kansas City, of Pathology, Chonbuk National University, Jeonju, Chonbuk National University, of Pathology, Sponsor: South Korea. Gibsonia, PA. HEALING BY WOUND IMPAIRED
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2 , 1 . 1, 6 , . 1 , T. T. , 1 SRL Inc., School 1, 2 . 4 2 1 Institut Health 3 2 Instituto TERRA, Inc., 1 2 , L. Gallicchio J. A. Flaws and J. . 1 , H. Uno , R. Garcia 3 1 1 1 G. Clark and G. Department 5 , M. Bouchard 3 . Center for 1 Xenobiotic Detection 6 , L. Torres Sanchez Torres , L. Hiyoshi Corporation,Hiyoshi G. Carrier and G. 5 and R. C. James 1, 2 2 2 , H. Zacur 1 Fukuoka Institute of Health & C. Schilling 3 , H. Horiguchi 1, 2 , M. Nakamura 4 , D. Shoen , D. , C. del Rio Garcia 1 2 CINVESTAV, DF and Merida, Mexico. CINVESTAV, 2 and L. Lopez Carrillo J. E. Chambers and J. 1 , N. C. Halmes , N. 1 , L. M. Lewis 3 , J. Zhao , J. 1, 2 Department of Epidemiology, Johns Hopkins Department of Epidemiology, 2 , H. Fukatu 3 Department of Epidemiology and Preventive and Preventive Department of Epidemiology Center for Community Medicine, Jichi Medical FL and Tallahassee, TERRA, Inc., , N. El Majidi , N. University and Occupational Health, Environmental of Gynecology and Obstetrics, Johns Hopkins of Gynecology Baltimore, MD. University, DETERMINATION OF PRESENT DETERMINATION OF BURDENS AND FUTURE BODY IN BIPHENYLS POLYCHLORINATED H. Gosselin N. CANADIANS. of Public Health, Hebei Medical University, Health, Hebei Medical University, of Public System International Inc., Durham, NC. AN LEUKEMIA: ACUTE AND PAINTING ANALYSIS. CAUSATION EVIDENCE-BASED Denver, CO. Denver, MEDIATE NOT LEVELS MAY ANDROGEN BETWEEN CURRENT ASSOCIATION THE FLASHES IN AND HOT ALCOHOL USE WOMEN. MIDLIFE Environmental Health Sciences, Mississippi State Environmental MS. Mississippi State, University, AND DURING DDE LEVELS BEFORE A LONGITUDINAL HUMAN PREGNANCY: Rothenberg S. J. STUDY. S. Miller 1 Baltimore, of Maryland, Medicine, University MD, 1 1 Japan, Tochigi, Kawachi-Gun, University, Shijiazhuang, China, Ohmi-Hachiman, Japan and QC, Canada. ON PERSISTENT STUDY COMPARATIVE CONTAMINATION ORGANIC POLLUTANTS IN HUMAN MILK IN HEBEI PROVINCE, Kayama F. JAPAN. TOKYO, AND CHINA S. Sun Iida Nacional de Salud Publica, Cuernavaca, Morelos, Cuernavaca, Nacional de Salud Publica, and Mexico 3 1 of Montréal, Montréal, QC, Canada, Canada, Longueuil, QC, Canada and M. E. Cebrián ASSESSING EXPOSURE LEVELS ASSESSING EXPOSURE FLEA CONTROL TO OF CHILDREN INSECTICIDES (CHLORPYRIFOS, AND TETRACHLORVINPHOS, THE FUR OF DOGS. PERMETHRIN) FROM S. Boone, J. Tyler, W. M. K. Davis, M. Russak, J. M. K. Ross Tachikawa, Tokyo, Japan, Tokyo, Tachikawa, J. K. Britt J. national de sante publique du Quebec, Montréal, national de sante publique Hernandez University, Baltimore, MD and University, Environmental Sciences, Fukuoka, Japan, Sciences, Fukuoka, Japan, Environmental 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#862 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #875 DISTRIBUTIONAL CONTROLS ON NON- #881 A DECISION TREE INCORPORATING LINEAR DOSE-RESPONSE RELATIONSHIPS. VAPOR INTRUSION INTO SCREENING RISK T. S. Bowers and B. D. Beck. Gradient Corporation, ASSESSMENTS OF HAZARDOUS WASTE Cambridge, MA. SITES. P. Wong-Yim, L. A. Sarmiento, M. J. Wade and B. K. Davis. Department of Toxic Substances #876 USE OF INTERNET-BASED SURVEYS Control, California Environmental Protection TO ACCESS GLOBAL OCCUPATIONAL Agency, Sacramento, CA. EXPOSURE DATA. D. MacNair2, J. Schell1, J. 2 3 1 Glenn and D. Tollerud . BBL Sciences, Houston, #882 EVALUATION OF THE RD50 FOR TX, 2Triangle Economic Research, Durham, NC and DETERMINING ACCEPTABLE LEVELS 3University of Louisville, Louisville, KY. OF EXPOSURE TO AIRBORNE SENSORY IRRITANTS. Y. Kuwabara, G. V. Alexeeff, R. L. #877 DNA CHIP-BASED GENE EXPRESSION Broadwin and A. G. Salmon. OEHHA, Oakland, CA. PROFILE DIFFERENCES BETWEEN SPECIES BY ORAL ADMINISTRATION #883 CRITICAL REVIEW OF TRADITIONAL OF TRICHLOROETHYLENE. N. Yoshioka, DRINKING WATER DEFAULTS FOR Y. sano, H. Nakashima, N. Etoh, Y. Nishiwaki, T. CHILDREN: IMPLICATIONS FOR RISK Takebayashi and K. Omae. Preventive Medicine and ASSESSMENTS. A. Arcus1, C. A. Caraway2, R. A. Public Health, School of Medicine, Keio University, Howd1 and A. M. Fan1. 1OEHHA, Cal/EPA, Oakland, Tokyo, Japan. Sponsor: M. Chiba. CA and 2OEHHA, Cal/EPA, Sacramento, CA. #878 INDOOR EXPOSURES AND RISK OF #884 THE ANALYSIS OF MIXED DISCRETE ASTHMA AND ALLERGY: A SYSTEMATIC AND CONTINUOUS OUTCOMES USING AND CRITICAL REVIEW. M. Lovik1, 2, J. V. DESIRABILITY FUNCTIONS. T. Coffey2, C. Bakke3, 4, K. H. Carlsen5, 8, J. A. Jensen2, K. I. Gennings3 and V. C. Moser1. 1NTD/NHEERL, Myhre6, 7, P. Nafstad8, 9, E. Omenaas3, 10, T. F. Wisloff6 U.S. EPA, Research Triangle Park, NC, 2Amylin and I. N. Norderhaug6. 1Division of Environmental Pharmaceuticals, San Diego, CA and 3Biostatistics Medicine, Norwegian Institute of Public Health, Department, VCU, Richmond, VA. Oslo, Norway, 2Faculty of Medicine, NTNU, Trondheim, Norway, 3University of Bergen, Bergen, #885 A DECISION-MAKING FRAMEWORK FOR Norway, 4Norwegian Labour Inspection Authority, SENSITIZATION SAFETY ASSESSMENT OF 1 2 Gjoevik, Norway, 5Voksentoppen BKL, National A NEW CHEMICAL. S. Kim , S. S. Kim and D. 1 1 2 Hospital (Rikshospitalet), Oslo, Norway, 6Norwegian H. Kim . ToxiSan, Fairfield, CA and University of Health Services Research Centre, Oslo, Norway, California, Berkeley, CA. 7 Clinic for Allergy and Pulmonary Diseases, #886 DEVELOPMENTAL TOXICITY AS 8 Oslo, Norway, University of Oslo, Oslo, Norway, AN ENDPOINT FOR HEALTH RISK 9 Norwegian Institute of Public Health, Oslo, Norway ASSESSMENT. G. L. Ball, C. J. McLellan and V. S. 10 and Haukeland University Hospital, Bergen, Bhat. Toxicology Services, NSF International, Ann Norway. Sponsor: E. Dybing. Arbor, MI. Sponsor: M. Dourson. #887 A RETROSPECTIVE ANALYSIS OF Tuesday, March 7 DEVELOPMENTAL STUDIES UTILIZED FOR 9:00 AM to 12:00 NOON THE RISK ASSESSMENT OF PESTICIDES. Exhibit Hall E. Mendez and E. Reaves. Office of Pesticides Program, U.S. EPA, Washington, DC. Sponsor: L. POSTER SESSION: RISK ASSESSMENT METHODS— Scarano. REGULATORY/POLICY #888 PRELIMINARY VALIDATION STUDIES Chairperson(s): Gunnar Johanson, Karolinska Institutet, Stockholm, OF BCO-P. E. Deparade, W. Wang-Fan and Sweden and Robert Howd, Cal/EPA, Oakland, CA. L. G. Ullmann. Toxicology, RCC Ltd., Itingen, Switzerland. Sponsor: K. Sachsse. TUESDAY Displayed: 9:00 AM–12:00 NOON #889 CONSIDERATIONS IN ASSESSING THE Attended: 9:00 AM–10:30 AM SIGNIFICANCE OF INCREASED INCIDENCE #879 INCORPORATING HAZARD OF LARGE GRANULAR LYMPHOCYTE IDENTIFICATION AND RISK ASSESSMENT LEUKEMIA (LGLL) IN F344 RATS FOR INTO AN OCCUPATIONAL HEALTH HUMAN CANCER RISK ASSESSMENT. P. AND SAFETY PROGRAM FOR ANIMAL J. Spencer1, J. I. Goodman2, J. K. Haseman3, T. P. RESEARCH. L. M. Milchak and D. C. Rothbauer. Loughran4, J. Thomas1 and J. M. Ward5. 1The Dow Environmental Health and Safety, University of Chemical Company, Midland, MI, 2Michigan State Pittsburgh, Pittsburgh, PA. University, East Lansing, MI, 3Consultant, formerly, NIEHS, Raleigh, NC, 4Penn State Cancer Center, #880 PROCESSES TO MINIMIZE GENOTOXIC Hershey, PA and 5Consultant, Montgomery Village, IMPURITIES IN PRODUCTION OF A NEW MD. DRUG SUBSTANCE. J. P. Bercu, C. M. Callis, J. M. Fiori and R. D. Meyerhoff. Toxicology and Drug Disposition, Lilly Research Laboratories, a Division of Eli Lilly and Company, Greenfield, IN. up-to-date information at www.toxicology.org 129
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and C. Yang and C. 1 . J. Robinson , J. Annual Meeting Annual 2 th , J. Morgan, Morgan, L. Li, J. G. V. Alexeeff V. G. , E. J. Matthews , E. J. 2 J. S. DOSE-RESPONSE. J. P. Iyer P. M. Golub, S. M. Hoover, GenMAPP, Gladstone Institute of Gladstone Institute GenMAPP, R. Benz 2 SOT's 45 SOT's Environmental Health, IRARC, UW, Health, IRARC, UW, Environmental , , M. L. Twaroski , M. L. , K. Hanspers 1 1 1 1 . VERSUS 1 . , E. Lee 1 Leadscope, Inc., Columbus, OH. 3 W. Griffith , W. 1 CFSAN/OFAS, USFDA, College Park, MD, MD, Park, College USFDA, CFSAN/OFAS, Spring, MD Silver CDER/OPS/ICSAS, USFDA, Seattle, WA and WA Seattle, THE IMPROVEMENT OF CANINE THE IMPROVEMENT A REGULATORY IN ACCOMMODATION S. Blakey. ENVIRONMENT. TOXICOLOGY Laboratories Ltd., Harrogate, United Covance UNDER EU DIRECTIVE 98/8/ WAIVING DATA DIRECTIVE): PRODUCTS EC (BIOCIDAL EXAMPLE SPARING A PRACTICAL ANIMALS IN 2000 APPROXIMATELY A RODENTICIDE. OF REGISTRATION Mayer , J. Beaumont, M. Campbell, J. Donald, Donald, M. Campbell, J. Beaumont, , J. Alexeeff V. Faust, A. Dunn, J. Laboratories Wrightson. Covance and M. Wood C. Ltd., Harrogate, United Kingdom. Sponsor: D. Everett 1 2 and . OEHHA, Cal/EPA, . OEHHA, Cal/EPA, Salmon R. Broadwin and A. G. CA. Oakland, PREVENT TO OF MEASURES VALIDATION DURING DOSE CONTAMINATION CROSS STUDIES. TOXICITY FOR PREPARATION Everett Kingdom. Sponsor: D. Yu M. Faustman Tomar Sherman and R. S. Sandy, C. D. RESPONSE FUNCTIONAL INTERPRETATION OF DOSE INTERPRETATION FUNCTIONAL MICROARRAY TIME-DEPENDENT AND INTEGRATION QUANTITATIVE DATA: FOR ANALYSIS OF GO ONTOLOGY ASSESSMENT. AND RISK TOXICOLOGY CalEPA, Oakland, CA. Oakland, CalEPA, CONCENTRATION- MATTER PARTICULATE F. Kauffman, G. Krowech, G. Krowech, Kauffman, F. K. B. Arvidson K. B. Cardiovascular Disease/UCSF, SF, CA. SF, Disease/UCSF, Cardiovascular AND DOSE-RESPONSE EXPOSURE HAZARD, CALIFORNIA’S ASSESSMENT UNDER 2006 UPDATE. 65: PROPOSITION . Food & Chemicals Practice, Exponent . Food Warren International, Harrogate, United Kingdom. FDA OF CONSOLIDATED THE CREATION THE DEVELOPMENT AND DATABASES TO ENTRY OF REAL-TIME DATA ACTIVITY STRUCTURE SUPPORT IN HAZARD APPROACHES RELATIONSHIP ASSESSMENT. AND RISK IDENTIFICATION . NCEA, U.S. EPA, Research EPA, White. NCEA, U.S. and L. D. Brown NC. Park, Triangle FOR BENCHMARK DOSE EVALUATION HUMAN IRRITATION.
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1 and Syracuse 2 , S. Chou 1 , M. Appel , M. 1 V. C. Moser and V. and R. Subramaniam A. S. Howard 3 1 Toxicology and Applied and Toxicology 2 . Occupational and and J. Shatkin. E. Barry and J. B. J. Zhao , E. Hack, J. , Y. Zhu Y. , 1 , M. Rennen NHEERL, Environmental NHEERL, Environmental 3 2 . , K. Crump A. Nong 1 Agency for Toxic Substances Toxic for Agency 1 A. Maier .
Food and Chemical Risk Analysis, Analysis, and Chemical Risk Food 2 1 and . . Environmental Health Shubat. Environmental and P. 1 , J. S. Gift , J. 3 . , J. Telman , J. 1 Imaging Systems, TNO, Delft, Netherlands. TNO, Imaging Systems, ENVIRON International Corp.,ENVIRON Ruston, LA and DC. Sponsor: Washington, EPA, NCEA, U.S. ORD, NCEA, Environmental Protection Agency, Research Agency, Protection NCEA, Environmental of South University and Biostatistics, Epidemiology Protection Agency, Research Triangle Park, NC and Park, Triangle Research Agency, Protection and F. Llados and F. and Disease Registry, Atlanta, GA and and Disease Registry, TNO, Zeist, Netherlands, TNO, RISK ASSESSMENT FOR ASSESSMENT RISK AND NANOTECHNOLOGY ADAPTIVE AN NANOMATERIALS: AND SAFETY FOR HEALTH APPROACH 3 Feron Sponsor: V. DECISION-MAKING. C. de Heer AN APPROACH FOR ESTIMATING FOR ESTIMATING APPROACH AN INTER- POPULATION-SPECIFIC FACTOR. VARIABILITY INDIVIDUAL 1 2 Gentry P. H. Goeden Minnesota Department of Health, St. Paul, Division, MN. VARIATION WITHIN-ANIMAL USING THE MINIMAL OF AN INDICATION AS APPLICABLE IN CRITICAL EFFECT SIZE APPROACH. THE BENCHMARK DOSE K. Krishnan Montréal, QC, Canada. A NUMERICAL OF IMPLEMENTATION NON-HOMOGENEOUS THE TO SOLUTION MVK MODEL OF CANCER. TWO-STAGE Triangle Park, NC, Park, Triangle FL. Tampa, Florida, THEIR AND IMMUNOLOGICAL ENDPOINTS MINIMAL OF DEVELOPMENT THE IN ROLE Abadin RISK LEVELS (MRLS). H. 1 3 A CONCEPTUAL FRAMEWORK FOR FRAMEWORK A CONCEPTUAL OF ADEQUACY THE EVALUATING HUMAN KINETICS THE DEFAULT FOR PROTECTING FACTOR UNCERTAINTY CHILDREN. Cincinnati, OH. TIME- A OF THE DEVELOPMENT ANALYZE TO DEPENDENT MODEL DATA TOXICITY NEUROBEHAVIORAL ASSESSMENT. FOR RISK The Cadmus Group, Watertown, MA. Watertown, The Cadmus Group, ARE CHRONIC RFDS REALLY CHRONIC? CHRONIC? RFDS REALLY ARE CHRONIC B. Fowler Sponsor: B. Research Corp, Syracuse, NY. Environmental Health, Universite de Montréal, Health, Universite Environmental Dekkers . Toxicology Excellence for Risk Assessment, Excellence for Risk Toxicology . Haber R. Wessel R. van Landingham van Pharmacology, TNO, Zeist, Netherlands and TNO, Pharmacology, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#895 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #906 REFERENCE SUBSTANCES FOR THE #913 A NOVEL APPROACH FOR DEFINING VALIDATION OF IN VITRO OCULAR SCREENING LEVELS FOR INDOOR AIR TOXICITY TEST METHODS FOR THE CONTAMINANTS (IACS). E. Hodge, G. EVALUATION OF OCULAR CORROSIVES Balagopal, A. Chiu and D. Manca. Standards AND SEVERE IRRITANTS. D. Allen1, 2, B. Development Branch, Ontario Ministry of the Blackard1, 2, N. Choksi1, 2, J. Truax1, 2, R. Tice2 and Environment, Toronto, ON, Canada. W. Stokes2. 1Integrated Laboratory Systems, Inc., Research Triangle Park, NC and 2NICEATM, #914 STRUCTURE-ACTIVITY ANALYSIS OF NIEHS, Research Triangle Park, NC. CHEMICAL HEALTH GUIDANCE VALUES. E. Demchuk1, B. C. Albin1, M. Fay1, R. M. Garrett2 and #907 ESTIMATED LIKELIHOOD FOR UNDER- H. Hansen1. 1Computational Toxicology Laboratory, AND OVER-CLASSIFICATION FOR A CDC/ATSDR, Atlanta, GA and 2Defense SEQUENTIAL DRAIZE RABBIT EYE TEST. N. Intelligence Agency, Washington, DC. Sponsor: B. Y. Choksi1, J. K. Haseman2, D. G. Allen1, R. R. Tice3 Fowler. and W. S. Stokes3. 1Integrated Laboratory Systems, Inc., Research Triangle Park, NC, 2Consultant, #915 PREDICTION OF SKIN ABSORPTION OF Research Triangle Park, NC and 3NICEATM, CHEMICALS USING STRUCTURE ACTIVITY 2 NIEHS/NIH/DHHS, Research Triangle Park, NC. RELATIONSHIP APPROACH. S. Basak , D. Mills2, S. Chou1 and M. Mumtaz1. 1CDC/ATSDR, #908 COMPARATIVE PERFORMANCE OF Atlanta, GA and 2University of MN Natural FOUR IN VITRO TEST METHODS FOR Resources, Duluth, MN. THE CLASSIFICATION OF OCULAR CORROSIVES AND SEVERE IRRITANTS. W. #916 RISK RANKING ALGORITHMS FOR S. Stokes1, N. Y. Choksi2, D. G. Allen2, J. F. Truax2 SOLVENT SUBSTITUTION IN THE and R. R. Tice1. 1NICEATM, NIEHS/NIH/DHHS, WORKPLACE. M. Debia, D. Begin, K. Krishnan Research Triangle Park, NC and 2Integrated and M. Gerin. Environmental and Occupational Laboratory Systems, Inc., Research Triangle park, Health, Universite de Montréal, Montréal, QC, NC. Canada. #909 EVALUATION OF THE RELATIONSHIP #917 SCIENTIFIC RATIONALE FOR DERIVING BETWEEN IN VIVO RABBIT EYE TEST DATABASE UNCERTAINTY FACTORS SCORES AND THEIR REVERSIBILITY. R. R. FOR SAFE DOSE ESTIMATES THAT ARE Tice1, D. G. Allen2, N. Y. Choksi2, J. F. Truax2 and PROTECTIVE OF CHILDREN. B. Gadagbui, M. W. S. Stokes1. 1NICEATM, NIEHS/NIH/DHHS, L. Dourson and A. Maier. Toxicology Excellence for Research Triangle Park, NC and 2Integrated Risk Assessment (TERA), Cincinnati, OH. Laboratory Systems, Inc., Research Triangle Park, #918 KEY STEPS NEEDED FOR EVALUATING NC. SENSITIVE TOXICOLOGICAL EFFECTS #910 CONSIDERING THE POTENTIAL FOR HAZARD IDENTIFICATION. H. 1 2 3 3 CUMULATIVE IMPACTS OF POLLUTANTS Choudhury , C. Moudgal , J. Colman and M. Odin . 1 2 IN DIVERSE GEOGRAPHIC AREAS OF ORD/NCEA, U.S. EPA, Cincinnati, OH, ORD, 3 CALIFORNIA. J. B. Faust, M. S. Sandy, L. Zeise U.S. EPA, Cincinnati, OH and Syracuse Research and G. V. Alexeeff. Office of Environmental Health Corporation, SRC, Syracuse, NY. Hazard Assessment, California Environmental Protection Agency, Oakland, CA. Tuesday, March 7 9:00 AM to 12:00 NOON #911 METHODS OF MANUFACTURE THAT Exhibit Hall REMOVE CONTAMINANTS FROM FISH OILS: INFORMATION COMPILED POSTER SESSION: DEVELOPMENTAL TOXICITY TESTING IN THROUGH THE GRAS (GENERALLY MAMMALIAN SYSTEMS RECOGNIZED AS SAFE) NOTIFICATION TUESDAY PROGRAM. A. Edwards, E. Garcia, C. Chairperson(s): Moussa Diawara, Colorado State University - Pueblo, Hendrickson and R. Chanderbahn. Division Pueblo, CO and Ali Faqi, MPI Research, Mattawan, MI. of Biotechnology and GRAS Notice Review (DBGNR), Office of Food Additive Safety (OFAS), Displayed: 9:00 AM–12:00 NOON Center for Food Safety and Applied Nutrition, Food and Drug Administration (U.S. FDA), College Park, Attended: 10:30 AM–12:00 NOON MD. #919 DI-(2-ETHYLHEXYL)-PHTHALATE #912 THE IMPORTANCE OF SUPPLIER ALTERS EXPRESSION OF FATTY ACID QUALIFICATION FOR VENDORS OF HOMEOSTASIS REGULATING PROTEINS MATERIALS USED IN IN VITRO ASSAYS. A. IN THE DEVELOPING RAT PLACENTA. Y. K. Ulrey, R. D. Curren and J. W. Harbell. Institute Xu, T. J. Cook and G. T. Knipp. Department of for In Vitro Sciences, Inc., Gaithersburg, MD. Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ.
up-to-date information at www.toxicology.org 131 . 1 ,
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, , . 1 1 . 1, 2, S. P. S. P. , I. 1 VIA . C. Lim H. G. , H. G. C. Lau 1 C. Elcombe C. C. Lim , J. Groten , J. 3 , M. Otto Department of 1 C. P. Curran , C. P. , H. Wortelboer , H. 1 and 1 2 2 . Analytical Sciences, Analytical 3 J. C. Benedict J. 1, 2, 3 Annual Meeting Annual Environmental Health, Environmental 1 th , M. L. Miller . 2 1 , I. Bobeldijk 2 , F. Salmon , F. , R. SharpeR. , , L. vd Horst 1 1 , J. R. Thibodeaux, R. M. Rosen, J. 1
Toxicology and Applied and Toxicology 1 SOT's 45 SOT's . 1 Department of Pathology, Chonbuk Department of Pathology, Physiological Sciences, TNO Quality Sciences, Physiological 2 2 and I. Chekarova , C. V. Vorhees V. , C. , H. Hendriks 1 2 , R. Jansink , A. Dijkstra , 1 1 1, 2, 3 D. W. Nebert W. and D. 1 . MRC Human Reproductive Sciences Unit, MRC Human Reproductive 2 Neurology, Cincinnati Children’s Hospital Research Cincinnati Children’s Neurology, CXR Biosciences Ltd., Dundee, United Kingdom CXR Biosciences Ltd., Dundee, , S. Ejaz Chonbuk National Department of Pathology, W. Pasman W. Foundation, Cincinnati, OH. Foundation, THE IN GENE EXPRESSION PROFILING EXPOSED LIVER OF PFOA AND LUNG University, Jeonju, South Korea. Sponsor: Jeonju, South Korea. University, Waalkens A. Miller MILK. K. MOTHER’S and D. de Groot and D. LOW DOSE INHALATION OF CIGARETTE DOSE INHALATION LOW OF DURATION SMOKE SHORTENS HORMONE ALTERS AND GESTATION AND FOR GESTATION LEVELS IMPORTANT MODEL. ANIMAL AN IN PARTURITION 2 MOUSE FETUSES. . Environmental . Environmental Zelikoff T. G. Steinetz and J. Ng, B. School of Medicine, University York Medicine, New NY. Tuxedo, AND DEVELOPMENTAL REPRODUCTIVE AROMATIC OF POLYCYCLIC TOXICITY (PAHS). HYDROCARBONS S. Eussen Netherlands, of Life, Zeist, Netherlands and TNO Quality of Life, Zeist, Netherlands. Sponsor: V. Feron THAN RATHER EXPOSURE IN UTERO Shertzer of Cincinnati, Cincinnati, OH and University IDENTIFICATION OF REGION-SPECIFIC IDENTIFICATION AND CHANGES GENE EXPRESSION AFFECTED BY PATHWAYS SIGNALLING RAT FOETAL IN PHTHALATE DIBUTYL Plummer S. TESTES. 1 and EXPOSURE OF ANGIOGENESIS BY DIRECT SMOKE SOLUTIONS WHOLE MAINSTREAM OF COMMERCIAL CIGARETTES. 3 3 T. P. Dalton P. T. National Center for Environmental Assessment, National Center for Environmental EPA, U.S. Office of Research and Development, DC. Washington, THE DIETS ON EFFECTS OF MATERNAL AND THE OFFSPRING DEVELOPMENT OF VULNERABILITY FOR CHEMICALLY ITS Wolterbeek A. INDUCED NEUROTOXICITY. C. R. Wood, R. D. Zehr, J. E. Schmid and J. Zehr, R. D. Wood, C. R. Triangle Research EPA, U.S. ORD/NHEERL/RTD, NC, Park, Edinburgh, United Kingdom. Edinburgh, OF NORMAL EMBRYONIC DISRUPTION and Jeonju, South Korea National University, COPLANAR HEXABROMOBIPHENYL HEXABROMOBIPHENYL COPLANAR LETHALITY IN HIGH-AFFINITY NEONATAL BY PRINCIPALLY AHR MICE IS CAUSED Pathology, Chonbuk National University, Jeonju, Chonbuk National University, Pathology, South Korea, Pharmacology, TNO Quality of Life, Zeist, Pharmacology,
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and 2 , K. H. 1 R. E. School 1 Molecular . 1 -DIOXIN P-DIOXIN Health , H. T. T. , H. 1 3 2 . , D. S. , D. and , M. Maekawa 1 2 2, 1 . School of , K. Toshimori , K. 3 Medical Sciences, School of Pharmacy, School of Pharmacy, 2 2 , J. Lim , J. School of Molecular 1 2 C. Vezina , C. School of Pharmacy, UW- Pharmacy, of School , M. C. Goldberg Department of Anatomy Anatomy Department of 1 2 2 . , Y. Toyama Y. , 1 1 J. B. Watkins B. , J. 2 Neurology, Medical College of College Medical Neurology, , F. Ishino , F. 4 3 and D. S. Henshel and D. 3 , H. Lee 1 and R. E. Peterson W. A. Fritz W. 2 and R. E. Peterson Medical Research Institute, Tokyo Tokyo Medical Research Institute, 3 R. Anahara R. Bioenvironmental Medicine, Chiba Bioenvironmental , M. Kai 1 1 . T. Lin T. T. Lin , T. J. T. Eells T. , J. , R. A. Sanders , R. 1 1, 4 4 1 C. Vezina C. and R. E. Peterson E. R. and 2 -DIHYDROTESTOSTERONE (DHT) HAS α-DIHYDROTESTOSTERONE Ctr Environ Health Sciences for Future Generations Ctr Environ and Environmental Toxicology Center, University of University Center, Toxicology and Environmental WI and Madison, Wisconsin, Madison, Madison, WI and Madison, Madison, Pharmacy, University of Wisconsin, Madison, WI. Madison, Wisconsin, of University Pharmacy, ACID OF RETINOIC MODULATION TO CONTRIBUTE MAY SIGNALING VENTRAL PROSTATIC OF IMPAIRMENT THE TCDD IN BY FORMATION BUD SINUS OF MALE FETAL UROGENITAL Allgeier M. Yoshida M. of Public and Environmental Affairs, Indiana Affairs, and Environmental of Public IN, Bloomington, University, C. Mori Chiba, Japan, 4 (NPO), Chiba, Japan. Medical and Dental University, Tokyo, Japan and Tokyo, Medical and Dental University, MICE. Kim TCDD EXPOSURE MAY BY IN UTERO INHIBITION OF TO CONTRIBUTE THE FROM FORMATION BUD PROSTATIC SINUS OF MALE VENTRAL UROGENITAL MICE. FETAL (TCDD). 5 NEAR INFRARED LIGHT THERAPY NEAR INFRARED LIGHT EMBRYO DIOXIN-INDUCED ATTENUATES Yeager R. L. MORTALITY. Millsap Whelan BUD VENTRAL PROSTATIC EFFECTS ON IN MICE INDEPENDENT OF FORMATION RECEPTOR. ANDROGEN THE CLASSIC . School of Pharmacy, UW-Madison, UW-Madison, . School of Pharmacy, Peterson WI. Madison, AND ICI 182.780 ON EFFECT OF FLUTAMIDE ASSOCIATE ADHESION THE CELL-CELL THE MOUSE SEMINIFEROUS IN PROTEINS TUBULES. Wisconsin, Milwaukee, WI. Milwaukee, Wisconsin, University, Chiba, Japan, University, and Developmental Biology, Chiba University, Chiba University, Biology, and Developmental Sciences, University of Wisconsin-Milwaukee, Wisconsin-Milwaukee, of Sciences, University WI and Milwaukee, University of Wisconsin, Madison, WI. Madison, Wisconsin, of University OF FEMALE DIFFERENTIATION TRANSPLANTS SINUS (UGS) UROGENITAL ALTERNATIVE AN IN NUDE MICE: VENTRAL INVESTIGATE TO MODEL BY 2, CAUSED AGENESIS (VP) PROSTATE 8-TETRACHLORODIBENZO- 7, 3, Pullman, State University, Washington Biosciences, WA. WITH BMP4 SIGNALING INTERFERENCE Indiana University, Bloomington, IN, IN, Bloomington, Indiana University, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#921 Program Description Description Program #922 #924
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #933 EVALUATION OF THE DEVELOPMENTAL #941 INTRACELLULAR GLUTATHIONE LEVELS TOXICITY OF ALPHA-ISO-METHYLIONONE INCREASE PRIOR TO DIFFERENTIATION IN RATS. V. T. Politano1, E. M. Lewis2, A. M. IN HL60 CELLS. S. M. Krance and N. Ballatori. Hoberman2, M. S. Christian3, R. M. Diener3 and A. Environmental Medicine, University of Rochester Api1. 1Research Institute for Fragrance Materials, School of Medicine, Rochester, NY. Inc., Woodcliff Lake, NJ, 2CRL Argus Research, Horsham, PA and 3Argus International, Inc., #942 CJC-1295, A LONG-ACTING GROWTH Horsham, PA. HORMONE RELEASING FACTOR ANALOGUE, IS NOT TERATOGENIC IN #934 ASSESSMENT OF PRENATAL RATS. V. Iordanova1, S. Wen1, E. Lewis2, S. Morseth3 DEVELOPMENT IN PBDE EXPOSED RATS and J. Castaigne1. 1ConjuChem, Inc., Montréal, QC, SUFFICIENT OR MARGINAL IN VITAMIN Canada, 2Charles River Laboratories Preclinical A. R. Ellis-Hutchings, G. Cherr and C. Keen. Services-Pennsylvania, Horsham, PA and 3Morseth University of California-Davis, Davis, CA. Consulting, LLC, Jefferson, MD. #935 A PRE- AND POSTNATAL STUDY OF #943 A DIETARY TERATOLOGY STUDY OF BICIFADINE HCL IN RATS. M. J. Beck1, J. P. A DRUG EXCIPIENT, AVICEL RCN-15®, Tizzano2, P. A. Krieter2, S. Ho1, D. W. Sved1 and IN SPRAGUE-DAWLEY FEMALE RATS. J. J. Buelke-Sam3. 1WIL Research Laboratories, McCarty1, M. Weiner1, C. Freeman2 and D. Nuber1. LLC, Ashland, OH, 2DOV Pharmaceutical, 1Toxicology, FMC Corporation, Princeton, NJ Inc., Hackensack, NJ and 3Toxicology Services, and 2Toxicology, Formerly of FMC Corporation, Greenfield, IN. Princeton, NJ. #936 A STUDY OF THE EFFECTS OF DAG #944 AN EXAMINATION OF CAGING (DIACYLGLYCEROL) ON EMBRYO/FETAL PROTOCOLS USED IN MOUSE DEVELOPMENT IN RATS. J. F. Knapp1, M. D. DEVELOPMENTAL TOXICITY RESEARCH. Nemec1, D. G. Stump1, B. J. Varsho1, O. Morita2, S. S. Dimond1, 2. 1Environmental Health and Y. Tamaki2 and H. Suzuki2. 1DART, WIL Research Safety, General Electric Plastics, Pittsfield, MA Laboratories, LLC, Ashland, OH and 2Safety and and 2Environmental Health and Toxicology, State Environmental Research, Kao Corporation, Haga University of New York at Albany, Albany, NY. Tochigi, Japan. #945 IN UTERO EXPOSURE TO BENZENE ALTERS #937 EFFECTS ON BIRTH WEIGHT AND ADULT EMBYRONIC PIM-1 SIGNALLING IN CD-1 HEALTH IN RATS PRENATALLY EXPOSED MICE. J. Wan1 and L. M. Winn1, 2. 1Pharmacology TO TOXICANTS OR UNDERNUTRITION. B. and Toxicology, Queen’s University, Kingston, ON, E. Grey, B. D. Barbee, J. Norwood, K. Das, C. Lau Canada and 2School of Environmental Studies, and J. M. Rogers. Reproductive Toxicology, ORD, Queen’s University, Kingston, ON, Canada. U.S. EPA, Research Triangle Park, NC. #946 EVALUATION OF THE TOXICITY AND #938 EVALUATION OF THE DEVELOPMENTAL TERATOGENICITY OF BENZENE AMINO- TOXICITY OF ALPHA-METHYL-3, 4- AND NITRODERIVATIVES FOR THEIR METHYLENE-DIOXYHYDROCINNAMIC REGULATION IN OCCUPATIONAL AIR. K. ALDEHYDE IN RATS. C. Letizia1, A. Api1, E. K. Kabirov and A. V. Lyubimov. Pharmacology, M. Lewis2, A. M. Hoberman2, M. M. Christian3 and Toxicology Research Laboratory, University of R. M. Diener3. 1Research Institute for Fragrance Illinois at Chicago, Chicago, IL. Materials, Inc., Woodcliff Lake, NJ, 2Charles River Laboratories Preclinical Services, Horsham, PA and #947 DIGITAL PHOTOGRAPHY OF NORMAL AND 3Argus International, Inc., Horsham, PA. MALFORMED VISCERAL SECTIONS OF DAY-20 FETAL RAT: AN EFFICIENT TOOL #939 8-MOP AND HEAVY METALS DISRUPT FOR TRAINING FUTURE DEVELOPMENTAL HAMSTER EMBRYO DEVELOPMENT. M. TOXICOLOGISTS. A. S. Faqi, S. Magness TUESDAY M. Diawara1 and D. Unis1. 1Biology, Colorado and K. Collison. Developmental & Reproductive State University-Pueblo, Pueblo, CO and 2Biology, Toxicology, MPI Research, Mattawan, MI. Colorado State University-Pueblo, Pueblo, CO. #940 A COMBINED REPEATED DOSE ORAL TOXICITY AND REPRODUCTIVE/ DEVELOPMENTAL TOXICITY-SCREENING STUDY OF 2-MERCAPTOETHANOL IN RATS. J. REGNIER1, W. Gaoua-Chappelle1, 2, O. Foulon2, V. Santa Cruz3 and R. Jaeckh4. 1ARKEMA, Paris-la-Defense, France, 2Centre International de Toxicologie (CIT), Evreux, France, 3Chevron- Phillips Chemicals Co., The Woodlands, TX and 4BASF AG, Ludwigshafen, Germany.
up-to-date information at www.toxicology.org 133
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B- CDC Huaian Branch, Huaian, 3 κ H. Luo . Pediatrics & L. Upham. Pediatrics and B. , . Pharmacology . Pharmacology E. Klaunig and J. 1 SOT's 45 SOT's L. Tang , L. 3 AND PI , Y. Tang Y. , 1 L. W. Chang W. and L. 1 , X. Hu 2 SER276 . Diagnostic Medicine/Pathobiology, A. Nguyen. Diagnostic Medicine/Pathobiology, and Molecular Toxicology, Chung Shan Medical Chung Shan Medical Toxicology, and Molecular and Taiwan Taichung, University, Kansas State University, Manhattan, KS. Kansas State University, IN DAMAGE DNA OF OXIDATIVE ROLE CARCINOGENESIS. HUMAN ESOPHAGEAL Z. wang Wang J. E. Trosko E. Blaha, J. Safety & and National Food Human Development, East State University, Michigan Center, Toxicology Lansing, MI. Nanjing, China and Jiangsu, China. OF PAKT ANALYSIS PP65 The Ohio . Internal Stoner Medicine, D. Nines and G. Columbus, OH. State University, BY OF GAP JUNCTIONS REGULATION TCDD IN BREAST CANCER CELLS. Armand-Frappier, Charbonneau. INRS-Institut du Quebec, Montréal, QC, Canada. Universite IN OF PHOSPHOLIPASES THE ROLE THE INHIBITION OF GAP JUNCTION ACTIVATION THE AND COMMUNICATION OF MAPK BY SPECIFIC ISOMERS OF 1. PART ANTHRACENES. METHYLATED INCREASED CELL PROLIFERATION AND INCREASED CELL PROLIFERATION TRANS, BY REDUCED P27 EXPRESSION 4-DECADIENAL TRANS-2, STRESS IN HUMAN BRONCHIAL EPITHELIAL CELLS. Chang Institutes, Kaoshiung, National Health Research Taiwan. OXIDATIVE INDUCES ACRYLONITRILE GLIAL CELLS. IN RAT DAMAGE DNA L. M. Kamendulis Nareddy B. V. IN COLON CANCER CELLS. and of Environmental Toxicology, Texas Tech University, University, Tech Texas Toxicology, of Environmental Health and Human The Institute of Environmental TX, (TIEHH), Lubbock, Gakhar, D. Lawn and A. Ngyuen Lawn D. Gakhar, Medicine/Pathobiology, KSU, Manhattan, KS. KSU, Medicine/Pathobiology, TRANSCRIPTION OF MODULATION CONNEXIN 32 TO BINDING FACTOR BY HEXACHLOROBENZENE PROMOTER IN FEMALE RATS. Environmental Health and Occupational Medicine, Environmental and Toxicology, Indiana University, Indianapolis, IN. University, Indiana Toxicology, and TPA BY OF GAP JUNCTIONS REGULATION NITROSOMETHYLBENZYLAMINE NITROSOMETHYLBENZYLAMINE RAT (NMBA)-INDUCED TUMORIGENESIS BY ESOPHAGEAL Chen, R. G. T. IMMUNOHISTOCHEMISTRY.
(Continued) Annual Annual th #957 #958 #959 #961 #954 #955 #960 #956 45 134 Meeting & ToxExpo & Meeting
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, I. Yang , I. 1 , V. Okoh V. , 1 Biochemistry and 1 . . Center for Health and 2, 1 Department of , B. Buckley , B. 1 1 Q. Felty Q. . 1 UMDNJ, Piscataway, NJ. Piscataway, UMDNJ, )/SP1 IN BREAST CANCER 2 α K. Reuhl and S. Safe , 1 2 Rutgers, The State University of NJ, of NJ, The State University Rutgers, 1 D. Roy and D. 2 . F. Matsumura and F. 1 Veterinary Physiology & Pharmacology, & Pharmacology, Physiology Veterinary 2 M. Gallo ,
1 Department of Anatomy and Cell Biology, and Cell Biology, Anatomy Department of Piscataway, NJ and Piscataway, S. Narayan the Environment, University of California, Davis, of California, Davis, University the Environment, CA. Davis, ANDROGEN STRUCTURE-DEPENDENT AGONIST/ANTAGONIST (AR) RECEPTOR AR DOWNREGULATION AND ACTIVITIES 1-BIS(3’- BY RING SUBSTITUTED 1, and (DIMS). L. Kotha INDOLYL)METHANES and Pharmacology, Physiology Veterinary . S. Safe TX. Station, College A&M University, Texas RAT ACI THE OF 2-D GEL COMPARISON AND MAMMARY GLAND MAMMARY F. Lim, R. A. Currie, K. Antrobus, D. J. Moore, H. J. Antrobus, D. A. Currie, K. Lim, R. F. Wright, J. Harris, S. Moreland, Odum, J. J. Tinwell, OF EPIGENETICS IN CARCINOGENESIS. moggs. G. G. Orphanides and J. Ashby, I. Kimber, J. CTL, Syngenta, Macclesfield, United Kingdom. TUMORS INDUCED BY 17B-ESTRADIOL. Lin PERSISTENT GENE EXPRESSION CHANGES IN INDUCED BY DIETHYLSTILBESTROL ROLE MOUSE UTERUS: THE NEONATAL 2 IN β-HEXACHLOROCYCLOHEXANE MICE. AND MMTV-NEU CELLS MCF10AT1 TX and CARCINOGENIC IN HUMAN BREAST EPITHELIAL CELLS. of Florida, Gainesville, FL. University TUMORGENICITY BY OF PROMOTION F. Wu CELLS. F. Station, College A&M University, Texas Biophysics, COMPLEX STRUCTURE-DEPENDENT COMPLEX STRUCTURE-DEPENDENT OF ESTROGEN ACTIVATION RECEPTOR(ER P. S. Wong S. P. Environmental & Occupational Health, Florida & Occupational Health, Environmental Miami, FL and International University, P. Thomas P. Texas A&M University, College Station, TX. Station, College A&M University, Texas ESTRADIOL IS 4-HYDROXYCATECHOL 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#951 #952 #950 : Stephen Safe, Texas A&M University, College Station, TX Station, College A&M University, Texas Chairperson(s): Stephen Safe, Indianapolis, IN. University, and Lisa Kamenduus, Indiana NOON AM–12:00 9:00 Displayed: AM AM–10:30 9:00 Attended: #948 9:00 AM to 12:00 NOON 9:00 Exhibit Hall MECHANISMS CARCINOGENESIS POSTER SESSION: Tuesday, March 7 March Tuesday,
#953 Program Description Description Program #949
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #962 DYSFUNCTION OF P27KIP1 IS ASSOCIATED #969 APOPTOSIS AND SENESCENCE IN WITH INCREASED MOUSE URINARY CARCINOGENIC MODELING USING MDM2- BLADDER TUMOR SIZE. K. Ogawa, A. P53 KNOCKOUT MICE. A. O. Chiu1, N. H. Hikosaka, S. Sugiura, M. Asamoto, S. Suzuki and T. Chiu2, D. V. Singh1, J. Beaubier3 and L. Donehower4. Shirai. Experimental Pathology and Tumor Biology, 1NCEA DC, U.S. EPA, Washington DC, DC, 2OST Nagoya City University Graduate School of Medical OW, U.S. EPA, Washington DC, DC, 3OPPTS, U.S. Sciences, Nagoya, Japan. EPA, Washington DC, DC and 4Medical Center, Baylor University, Houston, TX. #963 OCHRATOXIN A BLOCKS METAPHASE- ANAPHASE TRANSITION, RESULTING IN #970 GENETIC SUSCEPTIBILITY OF THE APOPTOSIS AND ABERRANT EXIT FROM TRP53 HAPLOINSUFFICIENT MOUSE TO MITOSIS. A. Mally, E. Rached and W. Dekant. RADIATION INDUCED LYMPHOMA. J. E. Department of Toxicology, University of Wüerzburg, French and V. Parron. NIEHS, NIH, Research Wüerzburg, Germany. Triangle Park, NC. #964 CONDITIONAL DOWN-REGULATION #971 REFINEMENT OF PCR-BASED DGGE FOR OF ARYL HYDROCARBON RECEPTOR ANALYSIS OF MUTATIONS IN THE P53 NUCLEAR TRANSLOCATOR INHIBITS TUMOR SUPPRESSOR GENE FOLLOWING TUMOR GROWTH AND ANGIOGENESIS IN IN UTERO EXPOSURE TO NRTIS. S. M. Torres1, A SUBCUTANEOUS MOUSE XENOGRAFTS 2, D. L. Cook2, D. M. Walker2, O. A. Olivero3, MODEL. S. T. Shi, D. Yoon, K. Hodge-Bell and O. M. C. Poirier3 and V. E. Walker2. 1Toxicology, Hankinson. University of California - Los Angeles, University of New Mexico, Albuquerque, NM, Los Angeles, CA. 2LRRI, Albuquerque, NM and 3Carcinogen-DNA Interactions Section, National Cancer Institute, #965 PPARβ INDUCES DIFFERENTIATION Bethesda, MD. AND INHIBITS CELL PROLIFERATION IN HUMAN AND MURINE KERATINOCYTES. #972 IN VIVO MUTAGENICITY AND INITIATION A. D. Burdick1, M. T. Bility1, D. Kim1, A. N. Billin2, ACTIVITY FOLLOWING OVEREXPRESSION T. M. Willson2 and J. M. Peters1. 1Department of OF OGG1 AND INCREASE OF 8- Veterinary Science, Center for Molecular Toxicology HYDROXYGUANINE FORMATION IN THE and Carcinogenesis, The Pennsylvania State KIDNEY OF RATS GIVEN POTASSIUM University, University Park, PA and 2Discovery BROMATE. T. Umemura1, K. Keita1, Y. Kuroiwa1, Research, GlaxoSmithKline, Research Triangle Y. Ishii3, K. Okano3, T. Nohmi2, A. Nishikawa1 and Park, NC. M. Hirose1. 1Division of Pathol., National. Institute Hlth. Sciences., Tokyo, Japan, 2Division of Genetics, #966 MIXED LINEAGE LEUKEMIA GENE Mutagenesis, National. Institute Hlth. Sciences., REARRANGEMENTS IN HUMAN Tokyo, Japan and 3Department.of Anal. Chem., HEMATOPOIETIC STEM CELLS EXPOSED Faculty of Pharma. Sciences., Hoshi University, TO ETOPOSIDE AND CHLORPYRIFOS. Tokyo, Japan. E. P. Gallagher1, J. Shao1, C. Moneypenny2, M. Eckert1, P. Stapleton1, T. Bammler1, R. Beyer1 and #973 IDENTIFICATION OF COVALENT F. Farin1. 1Environmental and Occupational Health MODIFICATIONS IN P450 2E1 BY 1, 2- Sciences, University of Washington, Seattle, WA EPOXY-3-BUTENE. G. Boysen1, C. O. Scarlett2, and 2Hematology and Oncology, St. Jude Children’s B. Temple3, N. I. Georgieva1, C. H. Borchers2 Research Hospital, Memphis, TN. and J. A. Swenberg1. 1Environmental Sciences and Engineering, University of North Carolina at #967 GENETIC ALTERATIONS IN CANCER: Chapel Hill, Chapel Hill, NC, 2Biochemistry and GENE MUTATIONS IN LUNG AND LIVER Biophysics, University of North Carolina at Chapel TUMORS OF MICE AND HUMANS EXPOSED Hill, Chapel Hill, NC and 3R. L. Juliano Structural 1 TO ENVIRONMENTAL AGENTS. M. Jackson , Bioinformatics Core, University of North Carolina 1 2 3 3 I. Lea , A. Rashid , S. Peddada and J. Dunnick . at Chapel Hill, Chapel Hill, NC. TUESDAY 1Health and Information Sciences Division, ILS, Inc., Research Triangle Park, NC, 2Software #974 URBAN DUST PARTICULATE MIXTURE Development, AGTI, Inc., Raleigh, NC and AFFECTS METABOLIC ACTIVATION 3Environmental Toxicology Program, NIEHS, OF PAHS IN V79 CELLS IN CULTURE. T. Research Triangle Park, NC. Musafia-Jeknic and W. M. Baird. Environmental and Molecular Toxicology, Oregon State University, #968 A NOVEL POLYMORPHIC RAT N- Corvallis, OR. ACETYLTRANSFERASE ALLELE (NAT3*2) WITH REDUCED CATALYTIC ACTIVITY IN #975 EFFECTS OF TREATMENT WITH VITRO. J. M. Walraven, D. F. Barker, M. A. Doll and MONOMETHYLARSONIC ACID (MMA-V) D. W. Hein. Pharmacology & Toxicology and Brown OR DIMETHYLARSINIC ACID (DMA-V) IN Cancer Center, University of Louisville, Louisville, THE DIET OR SODIUM ARSENATE (AS-V) IN KY. THE DRINKING WATER ON THE BLADDER EPITHELIUM OF FEMALE F344 RATS. L. L. Arnold1, M. Lu2, X. C. Le2, N. Clark1, M. Cano1 and S. M. Cohen1. 1University of Nebraska Med. Ctr, Omaha, NE and 2University of Alberta, Edmonton, AB, Canada. up-to-date information at www.toxicology.org 135
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, P. Yue , P. 1, 2, 3 2 1, 2, 3 , T. Miyagishima T. , 1 National Institute of 2 Annual Meeting Annual th and L. Mertz J. Kwekel , J. 2 C. J. Fong , C. J. Biochemistry & Molecular 1 . 1, 2, 3 . 1, 2, 3 S. M. Bello, C. L. Smith, 1, 2, 3 , T. Urusidani T. , 1 SOT's 45 SOT's National Institute of Biomedical 1 M. Hahn . 2 , E. Dere , A. Shlionska , 2 Research and Development, Gene Logic Gene Logic Research and Development, 1, 2, 3 2 , B. Ganter, K. Kolaja Ganter, , B. , M. Fielden L. D. Burgoon , L. D. 1, 2 National Food Safety & Toxicology Center, Center, Toxicology Safety & National Food 2
Center for Integrative Toxicology, Michigan State Michigan Toxicology, Center for Integrative Inc., Gaithersburg, Gene Logic Toxicogenomics, Michigan State University, East Lansing, MI and State University, Michigan Biology, Michigan State University, East Lansing, State University, Michigan Biology, Innovation, Osaka, Japan and Innovation, TOXICOGENOMICS COMPARISON OF THE OF COMPARISON TOXICOGENOMICS SPECIES DIFFERENCE OF PPARALPHA A. Ono LIGAND. H. Dene, D. L. Burkart, L. L. Washburn, I. Lu, M. I. Lu, M. Washburn, L. Burkart, L. L. H. Dene, D. Richards-Smith, B. Anagnostopoulos, A. Tomczuk, Eppig. Mouse Genome T. M. Cassell, H. Onda and J. Bar Harbor, The Jackson Laboratory, Informatics, East Lansing, MI. University, DATA DATABASES: MICROARRAY ORGANIZATION STORAGE, FORMATS, FIRST EXPERIENCE ANALYSIS. AND Borlak Soelle and J. D. ARRAYTRACK. WITH Campbell J. Brennan and T. Nagao T. and Hung Zacharewski and T. MI, 3 ENHANCEMENT OF CANINE MICROARRAY TOXICOGENOMIC-BASED AUGMENTING BY ANALYSIS DATA Liu Q. ANNOTATION. GENOMIC 1 MD and THE MOUSE GENOME INFORMATICS INFORMATICS THE MOUSE GENOME FOR APPLICATIONS DATABASE: TOXICOLOGISTS. ME. Sponsor: T. Inoue Japan. Sponsor: T. Tokyo, Health Sciences, Natsoulis, C. Pearson, A. Tolley and A. Roter. Iconix A. Roter. and Tolley A. Natsoulis, C. Pearson, CA. View, Pharmaceuticals, Mountain Fraunhofer Institut of Toxicology and Experimental and Experimental Toxicology Institut of Fraunhofer Germany. Medicine, Hannover, APPLICATIONS AND TECHNOLOGY MOTIF MECHANISM THE IN UNDERSTANDING A. ACTION. AND TOXICITY OF DRUG B. M. Lee, S. Dunlea, Yang, J. Vladimirova, Tugendreich, Calvin, S. Eynon, M. Ghosh, J. DATA VISUALIZATION METHODS FOR VISUALIZATION DATA TOXICOGENOMICS. COMPARATIVE Boverhof Mattes Sponsor: W. MD. Inc., Gaithersburg,
(Continued) Annual Annual th #989 #986 Tuesday, March 7 March Tuesday, AM to 12:00 NOON 9:00 Exhibit Hall BIOINFORMATICS POSTER SESSION: East State University, Michigan Zacharewski, Timothy Chairperson(s): MI. Lansing, NOON AM–12:00 9:00 Displayed: AM–12:00 NOON Attended: 10:30 #984 #988 #987 #985 45 136 Meeting & ToxExpo & Meeting .
, , A. , 4 C. , L. . . 1, 3 3 , 1 L. M. Drug Safety School and 1 2 1 . , Y. Ishii Y. , 1 1 IN Center for 4 , M. Cano 2 , M. Yamamoto , M. 4 , T. Sanderson T. , 1 Divison of Pathology, of Pathology, Divison 1 and R. H. Schiestl Department of Pathology Department of Pathology H. Badham . 3
1 Pharmaceutical Science, 3 , Y. Kitamura Y. , , J. Mitroka , J. 1 1 , K. Itoh 2 , R. White , R. 1 and M. Dominick 3 R. Reliene . , and M. Hirose 1 , Y. Kodama Y. , , B. Schilling , B. M. Ema , T. Umemura T. , Pharmacology and Toxicology, Queen’s Queen’s Toxicology, and Pharmacology 1 1 S. Cohen 1 1 Z. Sobol ,
. 3 T. Van Vleet Van T. 1, 2 Nonclinical Pharmacokinetics, Bristol-Myers . Pharmacology and Toxicology, UC Toxicology, and R. H. Rice. Pharmacology 2 Divison of Toxicology, National Institute of Health Toxicology, of Divison Winn and Microbiology, University of Nebraska Medical University and Microbiology, Omaha, NE. Center, MODE PLAUSIBLE A BIOLOGICALLY FOR FORMALDEHYDE- ACTION OF INDUCED LYMPHOHEMATOPOIETIC Vandenberg J. J. DeVoney, D. MALIGNANCIES. Davis, Davis, CA. Davis, Davis, THE AND CARCINOGENIC CR(VI) CR(III) SUPPLEMENT NUTRITIONAL AND YEAST DELETIONS IN INDUCE DNA Japan, Tokyo, National Institute of Health Sciences, DYNAMIC MUTATIONAL FINGERPRINT MUTATIONAL DYNAMIC IN CANCERS DAMAGE ACQUIRED OF TO SUBJECTS EXPOSED FROM P. Finkelstein, S. D. TRICHLOROETHYLENE. Integrated RedPath Wilson. and M. M. A. Swalsky Perdew Sponsor: G. PA. Pittsburgh, Pathology, Arnold DEFENSE SYSTEM AGAINST AGAINST DEFENSE SYSTEM VIVO POLLUTANT, AN ENVIRONMENTAL Y. EXPOSURE. PENTACHLOROPHENOL Kuroiwa R. Waites R. School of Public Health, University of California, Health, University School of Public CA. Berkeley, BLADDER URINARY SUBCHRONIC IN MALE EFFECTS OF MURAGLITAZAR RATS. University, Kingston, ON, Canada and Canada Kingston, ON, University, . NCEA, U.S. EPA, Washington, Washington, EPA, Whalan. NCEA, U.S. E. and J. DC. Squibb, Princeton, NJ and K. Kanki 2 Japan, Tokyo, Sciences, Japan and Tokyo, Hoshi University, Sponsor: MICE. ARSENITE MAINTAINS GERMINATIVE GERMINATIVE ARSENITE MAINTAINS OF EPIDERMAL CELLS BY STATE Patterson J. T. WNT SIGNALING. ALTERING and Nishikawa TARA, University of Tsukuba, Tsukuba, Japan. Tsukuba, of University TARA, Smith T. Guo, L. Li, X. Zhao and M. W. L. Zhang, Evaluation, Bristol-Myers Squibb, Evansville, Squibb, Evansville, Bristol-Myers Evaluation, IN, THE ROLE OF THE AHR IN BENZENE- THE OF THE ROLE BENZENE, TOXICITY: INITIATED AND BENZOQUINONE HYDROQUINONE OR ACTIVATION INDUCE DRE DO NOT CYP1A1 EXPRESSION. of Environmental Studies, Queen’s University, University, Studies, Queen’s of Environmental Canada. Kingston, ON, THE BENZENE FROM GENETIC DAMAGE IN HUMAN HYDROQUINONE METABOLITE CELLS. AND PROGENITOR BLOOD STEM Pathology, David Geffen School of Medicine at Geffen David Pathology, CA. Angles, UCLA, Los OF NRF2 IN ROLE A CRUCIAL 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#983 #977 #979 #982 #976
#980 Program Description Description Program #981 #978
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #990 GENOME REANALYSIS OF ARYL #997 APPLICATION OF LITERATURE MINING TO HYDROCARBON RECEPTOR BATTERY TOXICOGENOMICS. J. Polman1, R. Frijters1, S. GENES: RECONCILIATION OF CURRENT Verhoeven1, M. Krajnc-Franken2 and V. Proutski1. AND PAST REGULATORY REGION 1Molecular Design & Informatics, Organon, Oss, ANNOTATIONS. L. D. Burgoon1, 2, 3 and T. Netherlands and 2Pharmacology, Organon, Oss, Zacharewski1, 2, 3. 1Biochemistry & Molecular Netherlands. Sponsor: H. Joosten. Biology, Michigan State University, East Lansing, MI, 2National Food Safety & Toxicology Center, #998 THE COMPARATIVE TOXICOGENOMICS 1 Michigan State University, East Lansing, MI and DATABASE (CTD). C. Mattingly , M. 1 1 2, 1 2, 3Center for Integrative Toxicology, Michigan State Rosenstein , A. Davis , J. Forrest and J. Boyer 1 1 University, East Lansing, MI. . Bioinformatics, MDI Biological Laboratory, Salisbury Cove, ME and 2Medicine, Yale University #991 THE ABCC GRID PROMOTER TFSITE School of Medicine, New Haven, CT. Sponsor: W. COMPARISON PAGE TO FIND SHARED Toscano. REGULATORY ELEMENTS FOR CO- REGULATED GENES IN TOXICOLOGY. Tuesday, March 7 G. Patton2, 1, I. A. Sidorov2, D. S. Dimitrov2, X. 9:00 AM to 12:00 NOON Xiao2, R. H. Shoemaker2, G. Tudor1, D. Covell2 Exhibit Hall and R. M. Stephens3. 1ORD/NCEA/IRIS, U.S. EPA, Washington, DC, 2National Cancer Institute POSTER SESSION: ACETAMINOPHEN - Frederick, Frederick, MD and 3SAIC, Frederick, MD. Chairperson(s): Patricia Ganey, Michigan State University, East Lansing, #992 DIFFERENTIAL GENE EXPRESSION IN MI and Jose Manautou, University of Connecticut, Storrs, CT. HEPATOCYTE SUBPOPULATIONS SORTED Displayed: 9:00 AM–12:00 NOON FROM ACETAMINOPHEN-TREATED MICE. C. White, M. Dabrowski, C. Fernandez, D. Botta, R. Attended: 9:00 AM–10:30 AM Beyer, T. Bammler and T. Kavanagh. Environmental and Occupational Health Sciences, University of #999 REOVIRUS EXPOSURE POTENTIATES Washington, Seattle, WA. ACETAMINOPHEN HEPATOTOXICITY. C. J. Amuzie1, 2, M. Li2, P. E. Ganey2, 1, R. A. Roth2, 1, C. #993 GENOMIC EFFECTS OF DIET F. Cuff3 and J. J. Pestka2, 1. 1Comparative Medicine RESTRICTION AND DRUG-INDUCED and Integrative Biology, Michigan State University, HEPATOTOXICITY IN MALE RAT LIVER. East lansing, MI, 2Center for Integrative Toxicology, S. Burel1, M. Fielden2, A. Fan1, R. Lum1, K. Michigan State University, East lansing, MI and Gungon1, P. Cauntay1, M. Weigele1 and A. Sacaan1. 3Department of Microbiology and Immunology, 1Preclinical, Neurocrine Biosciences, San Diego, CA West Virginia University, Morgantown, WV. and 2Iconix Pharmaceuticals, Mountain View, CA. #1000 WHOLE BLOOD CARRIES GENE #994 PATHWAY ANALYSIS AND COMPARISON EXPRESSION SIGNATURES INDICATIVE OF OF TWO IN VITRO MICROARRAY STUDIES APAP-INDUCED TOXICITY. A. N. Heinloth1, OF VASCULITIS INDUCING COMPOUNDS J. Parker2, J. Chou1, G. Boorman3, R. Irwin3, M. USING HUMAN AND RAT ENDOTHELIAL Cunningham3, M. Snell3, R. Tennant1 and R. S. CELLS. B. lu1, B. Enerson1, Y. Zhou2, G. Floyd1 and Paules1. 1NCT, NIEHS, Research Triangle Park, NC, M. Lawton1. 1Safety Sciences, Pfizer, Groton, CT 2Constella, Research Triangle Park, NC and 3ETP, and 2Safety Sciences, Pfizer Inc., Nagoya, Japan. NIEHS, Research Triangle Park, NC. #995 INVESTIGATION OF THE MOLECULAR #1001 INDUCTION OF MRP4 AFTER MECHANISM OF HEPATOTOXICITY OF ACETAMINOPHEN TREATMENT IS A G-PROTEIN COUPLED RECEPTOR INDEPENDENT OF CAR AND PXR 1 2 ANTAGONIST USING TOXICOGENOMICS. EXPRESSION. L. M. Aleksunes , W. Huang , L. TUESDAY A. Roberts. Toxicology, Sanofi-Aventis M. Augustine3, M. Goedken1, N. J. Cherrington3, Pharmaceuticals, Malvern, PA. D. D. Moore2 and J. E. Manautou1. 1Department Pharmacology Sciences., University of Connecticut, #996 COMPUTATIONAL IDENTIFICATION OF Storrs, CT, 2Department Mol. and Cell. Bio., Baylor REGULATORY RESPONSE ELEMENTS College of Medicine, Houston, TX and 3Department IN THE GENOMIC SEQUENCE OF TCDD- Pharmacology and Toxicology, University of INDUCED CO-REGULATED HEPA1C1C7 Arizona, Tucson, AZ. PRIMARY RESPONSE GENES. W. Lang1, 2, L. D. Burgoon1, 2, 3, E. Dere1, 2 and T. Zacharewski1, 2, 3. #1002 HEPARIN ATTENUATES ACETAMINOPHEN- 1Biochemistry & Molecular Biology, Michigan State INDUCED HEPATOTOXICITY IN MICE. University, East Lansing, MI, 2National Food Safety T. M. Eagle1, S. W. Newport1, J. F. Maddox1, & Toxicology Center, Michigan State University, J. P. Luyendyk2, P. E. Ganey1 and R. A. Roth1. East Lansing, MI and 3Center for Integrative 1Pharmacology & Toxicology, Michigan State Toxicology, Michigan State University, East University, East Lansing, MI and 2Immunology, The Lansing, MI. Scripps Research Institute, La Jolla, CA. up-to-date information at www.toxicology.org 137 ,
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Center for Curriculum in 2 1 West Virginia Virginia West 2 . , L. M. Graves 1 3, 1 Annual Meeting Annual . th M. Terneus M. Department of Food Department of Food 1 . M. Valentovic and M. 2 L. Tal L. T. 1, 2 2+ P. A. CHEMICAL RESCUE. P. SOT's 45 SOT's VIA and J. M. Samet and J. 3 , A. Prince , 1 . Laboratory of Molecular and L. R. Pohl . J. Pestka and J. 1 J. P. P. J. ON PROLIFERATION. β INHIBITOR Human Studies Division, NHEERL, Chapel Human Studies Division, 3
Pharmacology, UNC-Chapel Hill, Chapel Hill, NC Pharmacology, Pharmacology, Marshall University School of University Marshall Pharmacology, PROTEIN KINASES ASSOCIATE ASSOCIATE KINASES PROTEIN THE WITH RIBOSOMES DURING RIBOTOXIC DEOXYNIVALENOL-INDUCED THE MACROPHAGE. STRESS RESPONSE IN M. Bourdi . Investigative Toxicology, Eli Toxicology, A. Davis. Investigative and M. Bailey Greenfield, IN. and Company, Lilly TYROSINE MECHANISM OF PROTEIN INHIBITION IN HUMAN PHOSPHATASE EPITHELIAL CELLS (HAEC) AIRWAY ZN TO EXPOSED Medicine, Huntington, WV and Medicine, Huntington, Immunology, NHLBI, National Institutes of Health, NHLBI, National Institutes Immunology, Bethesda, MD. R. Silbajoris 2 and Hill, NC. Sponsor: I. Jaspers Cincinnati, OH. RAPID ANALYSIS OF SRC SIGNALING OF SRC SIGNALING ANALYSIS RAPID PATHWAYS H. Bae East Lansing, MI. THE EFFECTS OF CELL OF A COMPARISON A SELECTIVE AND PERMEABLE FRATTIDE GSK3 Kiningham 1 DISEASE. INDUCED MURINE LIVER Cole. Pharmacology and Molecular Sciences, Johns Cole. Pharmacology Sponsor: J. Baltimore, MD. Hopkins University, Kramarik THE ROLE OF THE IKK AND THE JNK AND THE IKK OF THE ROLE Z. Peng, TOXICITY. ARSENIC IN PATHWAYS of Cincinnati, Xia. University and Y. L. Peng Integrative Toxicology, Michigan State University, State University, Michigan Toxicology, Integrative Toxicology, UNC-Chapel Hill, Chapel Hill, NC, Toxicology, COMPARISON OF S-ADENOSYL- COMPARISON AND L-METHIONINE (SAME) EFFECT ON (NAC) N-ACETYLCYSTEINE INDUCTION MEDIATED ACETAMINOPHEN MICE. IN TOXICITY OF Science and Human Nutrition, Michigan State Science and Human Nutrition, Michigan East Lansing, MI and University, Wesleyan College, Buckhannon, WV. Buckhannon, College, Wesleyan INTERLEUKIN-13 HEPATOPROTECTIVE AND CYTOKINES AFFECTS DIVERSELY ACETAMINOPHEN- CHEMOKINES IN
(Continued) Annual Annual th #1012 #1014 Tuesday, March 7 March Tuesday, : James Pestka, Michigan State University, East Lansing, East Lansing, State University, Michigan Pestka, Chairperson(s): James and Health, Occupational Safety Institute for National MI and Min Ding, WV. Morgantown, AM–12:00 NOON 9:00 Displayed: AM–12:00 NOON Attended: 10:30 #1011 #1013 9:00 AM to 12:00 NOON 9:00 Exhibit Hall SIGNALING KINASE POSTER SESSION: #1015 #1009 #1010 45 . 138 1 1, Meeting & ToxExpo & Meeting
. 1, 1 , 4 Food Food 7 1, 2, 3 , J. , J. , J. , J. and M. 4 3 and , V. V. , 7 , G. 2, 3 1 3, 2, 1 J. R. , J. 1 Department 1 J. E. Manautou E. J. A. V. V. , A. . 1 R. A. Roth , R. 1 Drug Disposition, C. R. Gardner 6 , S. X. Duan , S. G. Wood , S. G. and H. Jaeschke 1 2 and Harvard Vanguard Vanguard Harvard 1, 2, 3 3, 1 , D. J. Greenblatt J. , D. 3 5 4 , E. H. Jeffery J. D. Laskin D. , J. 6 Department of , P. R. Sinclair , P. 2 1, 3 9 J. Chilakapati , J. L. M. Aleksunes , L. M. 1 1 S. P. Sawant S. P. Pharmacology & Toxicology, Toxicology, & Pharmacology , H. Yohe , H. 1 3 K. K. Wolf K. K. Metabolism, NCI, Bethesda, . 9 P. E. Ganey , P. NCTR, Jefferson, AR. NCTR, Jefferson, Pharmacology and Toxicology, Toxicology, and Pharmacology Safety Sciences, Pfizer Global H. M. Mehendale 2 1 University of North of Carolina, University 3 1, 2, 3 2 Rutgers University, Piscataway, NJ, NJ, Piscataway, Rutgers University, . J. J. Lemasters J. , J. 1 S. Barnes 1 1, 2, 3
. , J. M. Dubois , J. , S. A. Wrighton A. , S. Safety Science, Pfizer Global R&D, MICE. and 3, 2, 1 4 1, 3 , M. S. Mitra 8 , F. J. Gonzalez J. , F. 2 , L. L. von Moltke , L. L. von 1 8 1, 3 5 , I. Pruimboom-BreesI. , , J. L. Allard L. , J. 2 3 VA Medical Center, White River Junction, River White Medical Center, VA Pharmacology and Experimental Therapeutics, Therapeutics, and Experimental Pharmacology , C. Cover 3 4 1 , T. M. Eagle T. , , J. P. Gray P. , J. NJ and Med. School, Piscataway, UMDNJ-RWJ NJ. EOHSI, Piscataway, National Food Safety & Toxicology Center, Center, Toxicology Safety & National Food State Michigan Toxicology, Center for Integrative Department Sciences., University of Pharmacology Biochemistry, Dartmouth Medical School, Hanover, Dartmouth Medical School, Hanover, Biochemistry, Liver Research Institute, University of Arizona, Arizona, of Institute, University Research Liver Tufts University, Boston, MA, University, Tufts Kostrubsky .of Toxicology, University of Louisiana Monroe, University Toxicology, .of D. L. Laskin D. J. F. Sinclair F. J. Michigan State University, East Lansing, MI, State University, Michigan M. H. Court Science and Human Nutrition, University of Illinois, Science and Human Nutrition, University Latendresse Monroe, LA and Research and Development, Groton, CT. Research and Development, OF REDUCED HEPATOTOXICITY (CAV-1) IN CAVEOLIN-1 ACETAMINOPHEN WITH ASSOCIATED MICE IS KNOCKOUT TISSUE REPAIR. INCREASED 3 2 3 ARE TYPE 2 DIABETIC MICE ACETAMINOPHEN FROM PROTECTED HEPATOTOXICITY. 1 Netherlands and 2 East Lansing, MI and State University, Michigan 3 East Lansing, MI. University, OF EXPRESSION PROTEIN ALTERED THE LIVER OF IN TRANSPORTERS ACETAMINOPHEN FOLLOWING PATIENTS OVERDOSE. of Connecticut, Storrs, CT, 2, 3 Maddox F. and J. 2 NH, VT, Urbana, IL, MD. FIBRIN DEPOSITION HEPATIC THE DEVELOPMENT OF DURING LIPOPOLYSACCHARIDE-POTENTIATED Newport W. S. TOXICITY. ACETAMINOPHEN CYP2E1(-/-) A. Hunt G. Szakacs NUCLEAR TRANSLOCATION OF TRANSLOCATION NUCLEAR APOPTOSIS- AND ENDONUCLEASE G DURING INDUCING FACTOR HEPATOTOXICITY. ACETAMINOPHEN Bajt 1 AZ and Tucson, Chapel Hill, NC. ACETAMINOPHEN OF CYP3A IN ROLE AND WILD-TYPE IN HEPATOTOXICITY Dnyanmote Dartmouth Medical School, Hanover, NH, Dartmouth Medical School, Hanover, Medical Associates, Boston, MA, Medical Lilly Research Laboratories, Indianapolis, IN, Indianapolis, IN, Research Laboratories, Lilly Scheffer Amsterdam, VU Medical Center, Pathology, Ann Arbor, MI and Arbor, Ann 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1007 #1008 #1006 #1005 #1004 #1003 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1016 THE EFFECTS OF PROTEIN ALKYLATION Tuesday, March 7 ON C-JUN N-TERMINAL KINASE 9:00 AM to 12:00 NOON 2, 1 1 SIGNALING. C. R. Orton and D. C. Liebler . Exhibit Hall 1Biochemistry, Vanderbilt University, Nashville, TN 2 and Pharmacology and Toxicology, University of POSTER SESSION: RESPIRATORY TRACT IRRITATION, Arizona, Tucson, AZ. INFECTION AND INFLAMMATORY INJURY #1017 HIGH-LEVEL OF INORGANIC PHOSPHATE Chairperson(s): Dan Morgan, NIEHS, Research Triangle Park, NC and INDUCE ANGIOGENESIS AND APOPTOSIS Madhusodana Nambiar, Walter Reed Army Institute, Silver Spring, MD. THROUGH AKT PATHWAY AND ERK-MNK SIGNALING PATHWAY IN VIVO AND IN Displayed: 9:00 AM–12:00 NOON VITRO LUNG SYSTEM. S. Chang, H. Jin and M. Cho. Toxiclogy, College of Veterinary Medicine, Attended: 9:00 AM–10:30 AM Seoul National University, Seoul, South Korea. #1023 EFFECT OF HEAVY NET SULFUR #1018 LOW INORGANIC PHOSPHATE POLLUTION ON RESPIRATORY DIET REGULATED BRAIN GROWTH CHARACTERISTICS OF WORKERS THROUGH AKT SIGNALING PATHWAY EXPOSED TO VOLCANIC EMISSIONS IN TRANSGENIC MICE EXPRESSING ON MIYAKE ISLAND IN JAPAN. H. Uno, BICISTRONIC LUCR-C-MYC-IRES-LUCF H. Horiguchi and F. Kayama. Division of REPORTER GENE. H. Jin, S. Hwang and M. Cho. Environmental Medicine, Center for Community Toxiclogy, College of Veterinary Medicine, Seoul Medicine, Jichi Medical School, Tochigi, Japan. National University, Seoul, South Korea. Sponsor: T. Yoshida. #1019 ESSENTIAL ROLE OF PROTEIN KINASE #1024 FLORIDA RED TIDE BREVETOXINS C IN SILICA-INDUCED MAP KINASE AND CAUSE PULMONARY EFFECTS THROUGH AP-1 ACTIVATION. M. Ding, Y. Lu, L. Bowman, MULTIPLE MECHANISMS. D. Baden1, S. V. Castranova and V. Vallyathnan. Pathology and Michelizza1 and W. Abraham2. 1UNCW Center for Physiology Research Branch, National Institute for Marine Science, Wilmington, NC and 2Department Occupational Safety and Health, Morgantown, WV. of Research, Mount Sinai Medical Center, Miami Beach, FL. #1020 TUMOUR-PROMOTING ACTIVITY OF MICROCYSTINS DURING #1025 ACUTE NOSE-/HEAD-ONLY EXPOSURE HEPATOCARCINOGENESIS IN OF RATS AND DOGS TO PHOSGENE. RATS: EFFECTS ON MAPKS SIGNAL CONCENTRATION X TIME DEPENDENCE TRANSDUCTION AND GSTPI EXPRESSION. OF NON-LETHAL-THRESHOLD J. Zhao1, 2, S. Jiang1, W. Qu1 and H. Zhu1. CONCENTRATIONS, INDICATORS 1Environmental Health, Fudan University, Shanghai, OF PULMONARY IRRITATION IN China and 2EOH, University of Pittsburgh, BRONCHOALVEOLAR LAVAGE, AND Pittsburgh, PA. ANALYSIS OF BREATHING PATTERNS. J. Pauluhn. Toxicology, Bayer HealthCare, Wuppertal, #1021 TYROSINE KINASE-MEDIATED Germany. ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASES BY A DI- #1026 SITE-SPECIFIC DEFINITION OF ORTHCHLORIANTED PCB IN LIVER ACUTE AIRWAY EPITHELIAL INJURY EPITHELIAL CELLS. B. V. Madhukar, G. Chen FOLLOWING A SINGLE EXPOSURE TO 1- and B. F. Wood. Pediatrics/Human Development, NITRONAPTHALENE-COATED CARBON Michigan State University, East Lansing, MI. BLACK PARTICLES. M. V. Fanucchi, L. Davison, B. DeLong, C. G. Plopper, I. M. Kennedy and A. R. #1022 SPLENOTOXIC RESPONSE OF ANILINE IS Buckpitt. University of California, Davis, CA. ASSOCIATED WITH EARLY ACTIVATION OF TUESDAY MITOGEN-ACTIVATED PROTEIN KINASES. #1027 BENEFICIAL ROLE OF NEUTROPHILS IN J. Wang and M. Khan. Pathology, University of REPAIR FROM 1-NITRONAPHTHALENE Texas Medical Branch, Galveston, TX. INDUCED LUNG INJURY. L. Sullivan, M. V. Fanucchi and C. G. Plopper. University of California, Davis, Davis, CA. #1028 SATRATOXIN G FROM THE BLACK MOLD STACHYBOTRYS CHARTARUM EVOKES OLFACTORY SENSORY NEURON LOSS AND INFLAMMATION IN THE MURINE NOSE AND BRAIN. Z. Islam1, 2, 3, J. R. Harkema3 and J. J. Pestka1, 2, 3. 1Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 2Department of Microbiology and Molecular Biology, Michigan State University, East Lansing, MI and 3Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI. up-to-date information at www.toxicology.org 139 . and 2 . Veterinary Veterinary L. 1 3
. R. H. N. and N. , D. Paulsen , D. 2, 3 1 J. M. and J. Annual Meeting Annual NIEHS, Research th 2 T. Gordon and T. 2 , A. Penn 1 J. Harkema , J. 1, 3 SOT's 45 SOT's R. Rouse CBS, SVM, LSU, Baton Rouge, LA, Baton Rouge, CBS, SVM, LSU, 1 Pharmacology and Toxicology, Toxicology, and Pharmacology S. S. Tinkle , S. S. 1 1 . 3 . 1, 3 J. Buchweitz J. , Y. Liang, D. Lechuga and G. Lalonde. Life Lechuga Liang, D. Y. via, Environmental Medicine, NYU School of Medicine, NYU School Environmental LA and Baton Rouge, PBS, SVM, LSU, and Diagnostic Investigation, Pathobiology State Michigan Toxicology, Center for Integrative Michigan State University, East lansing, MI, East lansing, State University, Michigan M. Tarantino M. Medicine, Tuxedo, NY and Tuxedo, Medicine, MI and East lansing, State University, Michigan East lansing, MI. University, ZYMOSAN ENHANCES TO PRE-EXPOSURE AND LUNG DEFENSE MECHANISMS THE PULMONARY ACCELERATES PATHOGEN A BACTERIAL CLEARANCE OF R. Roberts J. Young, S. IN RATS. Sciences, Nektar Therapeutics, San Carlos, CA. Sciences, Nektar AEROSOLIZED EFFECT OF DICHOTOMOUS MODEL OF A HAMSTER IN HYALURONAN P. P. LUNG INJURY. ENDOTOXIN-INDUCED O. M. Cerreta and J. Nadkarni, J. G. S. Kulkarni, Allied Health Professions, St Pharmacy and Cantor. Trombetta L. Sponsor: York. New University, John’s D. Horohov D. MOUSE STRAIN DIFFERENCES IN HYPERSENSITIVITY. BERYLLIUM 1 OFFSPRING. 2 OF INFLUENZA-INDUCED EPITHELIAL MUCOUS AND REGENERATION, INJURY, WITH CORRELATION CELL METAPLASIA IN CELL INFILTRATE INFLAMMATORY TO OF C57BL/6J AIRWAYS THE PULMONARY MICE. Kaminski 2 3 WV. Antonini. NIOSH, Morgantown, Syl Triangle Park, NC. Park, Triangle ALLERGIC PHENOTYPE MATERNAL ALLERGIC RESPONSES OF IMPACTS CHARACTERIZATION OF BIOCHEMICAL, OF BIOCHEMICAL, CHARACTERIZATION AND PHYSIOLOGICAL CELLULAR, INTRATRACHEAL CHANGES FOLLOWING OF FLUORESCEIN ADMINISTRATION LUNG. B. THE RAT TO ISOTHIOCYANATE C. Pfeiffer, , J. Wolff R. Sweeney, T. Vuillemenot, Casavant, M. Varney, H. Boeckman, A. Linger A. Linger H. Boeckman, Varney, M. Casavant, Center Health Research Courson. Naval and D. Wright- Laboratory, Health Effects Environmental Wilfong OH. Sponsor: E. AFB, Patterson THE CYTOTOXICOLOGICAL EFFECTS AND EFFECTS THE CYTOTOXICOLOGICAL RESPONSE OF MULTIPLE INFLAMMATORY JET FUEL. TO LUNG CELL LINES Sciences, University of Kentucky, Lexington, KY. Lexington, of Kentucky, Sciences, University MORPHOMETRIC CHARACTERIZATION
(Continued) Annual Annual th #1039 #1042 #1038 #1040 #1037 #1036 #1041 45 140 , 2 , Meeting & ToxExpo & Meeting 2
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, R. and 2 2 E. Kimmel Operational , 2 , M. Horsman 1 1 D. L. D. Edgewood Edgewood 1 Environmental Environmental , R. L. Kristovich 5 1 . 1 D. R. Germolec , D. L. T. Burka T. , L. 4 1 Experimental 2 E. Kimmel P. A. Dabisch and P. , A. S. Howard , 2 , 1 Geo-Centers, INC., , D. A. McCaskey , D. 2 2 , E. Davis 1 , T. E. Moran T. , 1 1 , P. Dabisch , P. 1 Medicine, USUHS, Bethesda, 3 Respiratory Biology, NIEHS, NIEHS, Respiratory Biology, Molecular Toxicology, NIEHS, Toxicology, Molecular 4 1 , P. J. Kirby J. , P. 2 Operational Toxicology, Geo- Toxicology, Operational . 2 4 Operational Toxicology, Edgewood Edgewood Toxicology, Operational 1 . S. Thomson and S. 1 , S. Garantziotis 1 , J. C. Carpin , J. , A. Howard , 4 1 1 Operational Toxicology, Edgewood Edgewood Toxicology, Operational , P. E. Rezk , P. 1 P. A. Dabisch , P. 1 . 1, 3 2 , D. McCaskey , D. 1 Biochemical Pharmacology, Walter Reed Walter Biochemical Pharmacology, , G. Flake , R. L. Kristovich 1 1 1 . R. L. Kristovich 2 SAIC, Abington, MD. SAIC, USAMRICD, Toxicology, Medical/Analytical Operational Toxicology, Geo-Centers, Inc., Toxicology, Operational Pharmacology and Chemistry, NIEHS, Research and Chemistry, Pharmacology Research Triangle Park, NC and Park, Triangle Research D. McCaskey D. Aberdeen Army, U.S. Center, Chemical Biological MD and Ground, Proving Army Institute of Research, Silver Spring, MD, Spring, MD, Institute of Research, Silver Army Mioduszewski and S. M. Palmer and P. Dabisch and P. P. Nambiar P. Sciuto 2 2 VX INHALATION EFFECTS OF ACUTE FLUID LAVAGE ON BRONCHOALVEOLAR AND LUNG BUTYRYLCHOLINESTERASE Graham P. IN GUINEA PIGS. J. INJURY MD and Edgewood, 1 MD and Ground, Aberdeen Proving PIGS. Kimmel C. Kimmel RESPIRATORY TRACT TOXICITY OF OF TOXICITY TRACT RESPIRATORY MICE. IN C57BL/6 DIACETYL 3 NC, Park, Triangle PURINERGIC SIGNALING PATHWAYS. PURINERGIC SIGNALING R. Kleeberger A. S. Howard Morgan . Toxicology Toxicology Morris. B. M. Lanosa and J. Vaughan, DepartmentProgram, of Pharmaceutical Sciences, of Connecticut, Storrs, CT. University OF A COMPARISON N- EXPOSURE-RESPONSE FOR CAPSAICIN, OR OLEORESIN VANILLYLNONANOAMIDE, INDUCED SENSORY AEROSOL CAPSICUM A. McCaskey D. IRRITATION. Toxicology, Edgewood Chemical and Biological and Biological Chemical Edgewood Toxicology, MD. Ground, Aberdeen Proving Center, THE OCULAR IRRITANCY ASSESSMENT OF AND OF OLEORESIN CAPSICUM (OC) IN GUINEA CAPSAICINOIDS RELATED Centers, Inc., Aberdeen Proving Ground, MD. Ground, Aberdeen Proving Centers, Inc., SIZE ON N- THE INFLUENCE OF PARTICLE AEROSOL (PAVA) VANILLYLNONANOAMIDE IRRITATION. INDUCED SENSORY Pathology, NIEHS, Research Triangle Park, NC, Park, Triangle NIEHS, Research Pathology, Research Triangle Park, NC, Park, Triangle Research Aberdeen Proving Ground, MD. Ground, Aberdeen Proving CARRIER DELIVERY THE EFFECT OF DRY AND PULMONARY THE EFFICACY ON J. “SYNTHETIC CAPSAICIN”. EFFECTS OF C. Carpin MD. CB Center, Aberdeen Proving Ground, MD and Ground, Aberdeen Proving CB Center, Immunology, NIEHS, Research Triangle Park, NC. Park, Triangle Research NIEHS, Immunology, STIMULATION IRRITANT-INDUCED NERVES TRIGEMINAL OF NASAL Chemical and Biological Center, Aberdeen Proving Aberdeen Proving Center, Chemical and Biological MD and Ground, J. C. Carpin J. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1035 #1029 #1031
#1033 Program Description Description Program #1032 #1034 #1030
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1043 RADIATION-INDUCED PULMONARY #1049 MAGNETIC NANOPARTICLES INHALATION FIBROSIS: EFFECT OF THE COMBINED TOXICITY IN MICE. J. Kwon1, C. Song2, T. ACTION OF EXTERNAL RADIATION AND Yoon3, D. Kim4, J. Kim1, H. Moon1, K. Yu1, S. CERIUM-144 ON THE DEVELOPMENT Park1, Y. Kang5, K. Han6, D. Han5, M. Choi4, J. OF FIBROUS PROCESS IN THE RATS Lee3 and M. Cho1. 1Laboratory of Toxicology, LUNG. Z. D. Paskalev1 and D. B. Apostolova2. College of Veterinary Medicine, Seoul National 1Radiotoxicology, National Center of Radiobiology University, Seoul, South Korea, 2Aerosole Dynamics and Radiation Protection, Sofia, Bulgaria and Laboratory, Gwangju Institute of Science and 2Occupational Toxicology, Clinic of Occupational Technology, Gwangju, South Korea, 3Materials Diseases, Medical University, Sofia, Bulgaria. Chemistry Laboratory, School of Chemistry, Sponsor: Z. Paskalev. Seoul National University, Seoul, South Korea, 4Nanotechnology & Thermal Processing Laboratory, #1044 TIME COURSE OF LUNG RESPONSE IN School of Mechanical and Aerospace Engineering, THE MOUSE TO PANCREATIC ELASTASE. Seoul National University, Seoul, South Korea, E. N. Potts, J. A. Voynow and W. M. Foster. Duke 5Seoul center, Korea Basic Science Institute, Seoul, University Medical Center, Durham, NC. South Korea and 6Seoul Toxicology Laboratory, Seoul, South Korea. Tuesday, March 7 #1050 PULMONARY TOXICITY SCREENING 9:00 AM to 12:00 NOON STUDIES IN MALE RATS WITH M5 Exhibit Hall RESPIRABLE FIBERS AND PARTICULATES. D. B. Warheit, K. L. Reed and T. R. Webb. DuPont POSTER SESSION: INORGANIC PARTICLES AND FUMES Haskell Laboratory for Health and Environment Chairperson(s): Vince Castranova, CDC-NIOSH, Morgantown, WV and Sciences, Newark, DE. Jon Hotchkiss, The Dow Chemical Company, Midland, MI. #1051 BIODEGRADABILITY OF PARA-ARAMID Displayed: 9:00 AM–12:00 NOON RESPIRABLE-SIZED FIBER-SHAPED PARTICULATES (RFP) IN HUMAN LUNG Attended: 10:30 AM–12:00 NOON CELLS: VALIDATION OF IN VIVO FIBER SHORTENING IN AN IN VITRO HUMAN #1045 INFLUENCE OF PARTICLE SHAPE ON CELLULAR SYSTEM. D. B. Warheit1, K. L. SILICA TOXICITY IN VITRO: IMPACT OF Reed1, J. D. Stonehuerner2, A. J. Ghio2 and T. R. SIMULATED LUNG MECHANICS, SURFACE Webb1. 1DuPont Haskell Laboratory for Health and TREATMENT, AND AGGREGATION. S. C. Environmental Sciences, Newark, DE and 2U.S. 1 2 2 2 Brown , M. A. Kamal , N. Nasreen , V. B. Antony EPA, Chapel Hill, NC. and B. M. Moudgil1. 1Materials Science and Engineering, and Particle Engineering Research #1052 TOXICOLOGIC ASSESSMENT OF INHALED Center, University of Florida, Gainesville, FL and ACICULAR MULLITE. J. A. Hotchkiss, S. M. 2Department of Medicine, University of Florida, Krieger, S. A. Wallin and K. D. Nitschke. The Dow Gainesville, FL. Sponsor: S. Roberts. Chemical Company, Midland, MI. #1046 DOES SANDBLASTED METAL ATTENUATE #1053 PULMONARY TOXICITY OF INDIUM OR ENHANCE THE TOXICITY OF SILICA PHOSPHIDE PARTICULATE IN B6C3F1 MICE SAND? V. Robinson, V. Castranova, S. Leonard, AFTER OROPHARYNGEAL ASPIRATION. P. M. Barger, D. Pack, G. Feather and V. Vallyathan. J. Kirby1, C. J. Shines1, H. C. Price2, G. Taylor2, J. HELD, NIOSH, Morgantown, WV. Everitt3, G. Hill4 and D. L. Morgan1. 1Respiratory Toxicology, NIEHS, Research Triangle Park, NC, #1047 REPEATED INHALATION TOXICITY OF 2Alion Science and Technology, Inc., Research SYNTHETIC AMORPHOUS SILICAS IN Triangle Park, NC, 3Consultant, Research Triangle RATS: EVALUATION OF THEIR TOXICITY Park, NC and 4Experimental Pathology, NIEHS, UP TO 3 MONTHS AFTER EXPOSURE. J. Research Triangle Park, NC. TUESDAY Arts, H. Muijser, E. Duistermaat, K. Junker and F. Kuper. Toxicology and Applied Pharmacology, TNO #1054 BUTADIENE SOOT INDUCES Quality of Life, Zeist, Netherlands. Sponsor: A. AUTOFLUORESCENCE AND Nordone. ULTRASTRUCTURAL DAMAGE IN CULTURED HUMAN RESPIRATORY #1048 PATHOLOGICAL STUDY ON THE EPITHELIAL CELLS AND CAUSES PULMONARY TOXICITY INDUCED BY INFLAMMATION IN MURINE AIRWAYS. THE INTRATRACHEALLY INSTILLED G. Murphy1, W. G. Henk1, D. B. Paulsen2, S. A. YELLOW SAND IN MICE. A. Shimada, O. Mina, Barker1 and A. Penn1. 1Comparative Biomedical K. Theerayuth, T. Morita and H. Inoue. Veterinary Sciences, Louisiana State University, Baton Rouge, Pathology, Tottori University, Tottori-shi, Japan. LA and 2Pathobiological Sciences, Louisiana State University, Baton Rouge, LA.
up-to-date information at www.toxicology.org 141
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and J. G. G. , J. 1 1 Laboratory CEMALB, CEMALB, Center for 1 2 3 . 1 D. L. Laskin D. Universtiy and Universtiy G. S. Backus G. 1 SPH, UNC, Chapel and I. Jaspers 2 1 , A. D. Ledbetter A. D. , , J. H. Richards , J. , R. Jaskot 1 2 2 SPH, UNC, Chapel Annual Meeting Annual 2 C. G. Plopper , C. G. 2 th , M. C. Schladweiler 1 , R. B. Lundquist , R. B. 1 Curriculum in Toxicology, Toxicology, Curriculum in 2 , H. Jeffries G. E. Hatch , G. 1 3 ETD/NHEERL/ORD, U.S. EPA, EPA, U.S. ETD/NHEERL/ORD, 1 College of Veterinary Medicine, Medicine, Veterinary of College ETD/NHEERL/ORD, U.S. EPA, EPA, U.S. ETD/NHEERL/ORD, SOT's 45 SOT's . , J. Wallenborn , J. 1 1 1 and S. R. Kleeberger 1 . 1 . . Environmental and Laskin. Environmental D. and J. NC State University Raleigh, NC. NC State University 1 1 3 , J. G. Wallenborn G. , J. 1 , M. C. Schladweiler 1 , E. M. Postlethwait 1 , D. Biscocho , D. K. G. Sexton , K. G. 1 1 ESE, UNC-CH, Chapel Hill, NC and Alabama of Health, University School of Public Walker , C. R. Comparative Respiratory Biology and Medicine, Respiratory Biology Comparative CA. Davis, of California at Davis, University OZONE-INDUCED EXACERBATION RECOMBINANT TO OF RESPONSE TLR4- A ALLERGEN IN COCKROACH Wagner Research Triangle Park, NC, Park, Triangle Research Universtiy of. P. Kodavanti P. of. Universtiy AL and at Birmingham, Birmingham, NIEHS/NIH, Research of Respiratory Biology, NC and Park, Triangle Occupational Health Sciences Institute, Rutgers Johnson Wood and UMDNJ-Robert University NJ. Medical School, Piscataway, HUMAN EXPOSURES OF REPEATED TO EPITHELIAL CELLS RESPIRATORY LEVELS OF OZONE SENSITIZES LOW THE EFFECTS INDUCED BY SUBSEQUENT OZONE OR HAPS. TO CHALLENGES 1 UNC-CH, Chapel Hill, NC. PRIOR EPISODIC OZONE EXPOSURE MUCOUS CELL METAPLASIA ALTERS TO IN RESPONSE AND INFLAMMATION NASAL OZONE EXPOSURE IN RAT ACUTE A. Carey S. AIRWAYS. 2 DEFICIENT MOUSE MODEL. 2 UNC, Chapel Hill, NC. INHALED TO SYSTEMIC RESPONSES AND DOWN- CACHEXIA OZONE IN MICE: OF LIVER XENOBIOTIC REGULATION C. Mathrani, K. V. GENES. METABOLIZING A. Last. Pulmonary and and J. Kenyon J. Gohil, N. of California, Critical Care Medicine, University CA. Davis, DISEASE-SPECIFIC SUSCEPTIBILITY TO TO DISEASE-SPECIFIC SUSCEPTIBILITY AND INJURY OZONE-INDUCED ACUTE STRAINS. IN EIGHT RAT INFLAMMATION Hill, NC. INFLAMMATORY OZONE-INDUCED ACUTE LUNG THE RAT IN GENE EXPRESSION LEVELS OF TO RELATED IS NOT FLUID. THE LAVAGE IN ANTIOXIDANTS K. Crissman Hill, NC and J. H. Richards J. Doyle F. Thomas F. Kodavanti P. of. L. Fakhrzadeh Michigan State University, East Lansing, MI, State University, Michigan INCREASED SENSITIVITY OF CAVEOLIN-1 INCREASED SENSITIVITY OF CAVEOLIN-1 OZONE. TO MICE KNOCKOUT Research Triangle Park, NC and Park, Triangle Research A. D. Ledbetter A. D. J. R. Harkema J. Jaskot
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. HELD/ K. G. K. G. , K. Galdanes 1 , G. Sykes 1 ESE, UNC-CH, , K. de Bruijne 1 1 . 1 T. Gordon and T. 2 CEMALB, UNC-CH, Chapel CEMALB, E. M. Vancza E. M. 2 , D. P. Kelly P. , D. , M. Doyle J. M. Antonini M. and J. 2 2, 1 J. Chen, J. Antonini, S. Stone, B. M. J. Otsuka Chemical Co., Osaka, Japan, Otsuka Chemical Co., Osaka, and H. Jeffries 2 1 , G. Hatch 1 Haskell Laboratory, DuPont Company, Company, DuPont Laboratory, Haskell 1 . 4 , A. Tanaka A. , , S. Young, Young, S. , Zeidler-Erdely C. P. . 2
, I. Jaspers J. R. Roberts J. 1
EPA, Triangle Park, NC. Park, Triangle EPA, Veterinary Pathology Services, West Grove, PA and PA Grove, West Services, Pathology Veterinary DE. Sponsor: Newark, Consulting, Pathology University School of Medicine, Tuxedo, NY and Tuxedo, School of Medicine, University THE ACUTE EFFECTS OF TUNGSTEN EFFECTS OF ACUTE THE AIRWAY. THE RAT ON (WA) ALLOYS K. P. Lee K. P. A. Gunnison 2 Sexton S. Ebersviller Chapel Hill, NC and Hill, NC. FOR INCREASED A GENETIC BASIS MOUSE THE NEONATAL SENSITIVITY OF OZONE. TO LUNG EXAMINING THE INFLAMMATORY THE INFLAMMATORY EXAMINING OF THE ROLE RESPONSES OF HAPS: PHOTOCHEMICAL OTHER AND OZONE PRODUCTS. TRANSFORMATION . Health Effects . Health Effects Antonini M. and J. S. H. Reynolds WV. NIOSH, Morgantown, Laboratory Division, FUME. J. Boeckman, E. W. Johnson, T. L. Naylor, D. P. P. D. L. Naylor, T. Johnson, W. E. Boeckman, J. RESPONSES. Cumpston and M. Donlin, J. A. Frazer, R. Roberts, WV. NIOSH, Morgantown, Frazer. D. WELDING IN SOLUBLE CHROMIUM TO FUME INCREASES SUSCEPTIBILITY INFECTION IN BACTERIAL PULMONARY RATS. . Naval Health Research . Naval Wilfong Arfsten and E. R. Health Effects Center Detachment Environmental OH. AFB, Wright-Patterson Laboratory, STEEL EFFECT OF STAINLESS ACUTE ON LUNG WELDING FUME INHALATION DEFENSE AND INFLAMMATION, INJURY, TWO-WEEK INHALATION STUDIES WITH STUDIES INHALATION TWO-WEEK POTASSIUM OF DISK-SHAPED PARTICLES TF) IN RATS. (TERRACESS OCTATITANATE S. Sakai 3 4 PPRB, NIOSH, Morgantown, WV. NIOSH, Morgantown, PPRB, LUNG INFLAMMATORY COMPARATIVE AND C57BL/6J MICE A/J RESPONSE IN WELDING STEEL STAINLESS TO EXPOSED Newark, DE, Newark, Loveless 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1056 #1061 9:00 AM–10:30 AM AM–10:30 Attended: 9:00 #1060 : Ilona Jaspers, University of North Carolina Chapel Hill, of North Carolina University Chairperson(s): Ilona Jaspers, Park, Triangle Research EPA, U.S. Chapel Hill, NC and Urmila Kodavanti, NC. AM–12:00 NOON 9:00 Displayed: Tuesday, March 7 March Tuesday, AM to 12:00 NOON 9:00 Exhibit Hall OZONE POSTER SESSION: #1058 #1057 #1055
#1059 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1069 AIRWAY AND INFLAMMATORY RESPONSES #1077 GENE EXPRESSION PROFILING OF RAT FOLLOWING IN-UTERO EXPOSURE TO AND HUMAN PRIMARY CULTURED ENVIRONMENTAL TOBACCO SMOKE ARE HEPATOCYTES IN RESPONSE TO MODIFIED BY POSTNATAL EXPOSURE TO DRUGS AFFECTING MITOCHONDRIAL OZONE. T. A. Akinbiyi, X. Gao, D. J. Bassett and FUNCTIONS. T. Shimizu, A. Ono, T. Miyagishima, D. K. Bhalla. Fund/Appl. Sciences, Wayne State T. Urushidani and T. Nagao. Toxicogenomics University, Detroit, MI. Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan. Sponsor: T. Inoue. #1070 OZONE-INDUCED LUNG TOXICITY IN RAT PUPS FOLLOWING IN UTERO EXPOSURE #1078 GENE EXPRESSION PROFILING IN TO ENVIRONMENTAL TOBACCO SMOKE. S. RAT LIVER TREATED WITH VARIOUS G. Han1, D. K. Bhalla2 and C. G. Gairola1. 1Graduate HEPATOTOXIC COMPOUNDS INDUCING Center for Toxicology, University of Kentucky, COAGULOPATHY. M. Hirode, A. Ono, T. Lexington, KY and 2Fund/Appl Sciences, Wayne Miyagishima, T. Urushidani and T. Nagao. State University, Detroit, MI. Toxicogenomics Project in Japan, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan. Sponsor: T. Inoue. Tuesday, March 7 9:00 AM to 12:00 NOON #1079 TOXICOGENOMIC APPROACH FOR Exhibit Hall EARLY ASSESSMENT OF POTENTIAL HEPATOCARCINOGENICITY OF POSTER SESSION: TOXICOGENOMICS CHEMICALS IN RATS. T. Uehara, A. Ono, T. Miyagishima, T. Urushidani and T. Nagao. Chairperson(s): William Mattes, Gene Logic Inc., Gaithersburg, MD. Toxicogenomics Project, National Institute of Displayed: 9:00 AM–12:00 NOON Biomedical Innovation, Ibaraki, Osaka, Japan. Sponsor: T. Inoue. Attended: 10:30 AM–12:00 NOON #1080 GENE EXPRESSION PROFILING IN RAT #1071 TRANSCRIPTIONPATH, A VALUABLE ASSAY LIVER TREATED WITH COMPOUNDS FOR DIRECT TRANSCRIPTION ANALYSIS, WHICH CHANGE PLASMA TRIGRYCERIDE. ACCURATELY QUANTIFIES TOXICOLOGIC K. Omura, A. Ono, T. Miyagishima, T. Urushidani GENE EXPRESSION CHANGES IN SAMPLES and T. Nagao. National Institute of Biomedical WITH DEGRADED RNA. M. Warren, V. Innovation, Ibaraki, Osaka, Japan. Sponsor: T. Inoue. Alexiadis, B. Egan and P. Labhart. Genpathway, Inc., San Diego, CA. Sponsor: Y. Dragan. #1081 COMPARISON OF DIFFERENTIAL GENE EXPRESSION IN BLOOD AND LIVER OF #1072 A BASELINE ANIMAL MICROARRAY LIPOPOLYSACCHARIDE TREATED RATS. R. DATABASE FOR BIOLOGICAL RESPONSE D. Fannin, J. T. Auman, M. E. Bruno, S. O. Sieber, IDENTIFICATION AND BIOMARKER C. J. Tucker, B. A. Merrick and R. S. Paules. National VALIDATION. J. Fostel. NCT, NIEHS ITSS, Center for Toxicogenomics, NIH_NIEHS, Research Research Triangle Park, NC. Sponsor: S. Pettit. Triangle Park, NC. #1073 RATE-LIMITING STEP ANALYSIS OF #1082 GENE EXPRESSION PATTERN ALTERATION TOXICOGENOMIC DATA. W. B. Mattes, K. K. IN GILL FROM ZEBRAFISH EXPOSED TO Daniels and M. S. Orr. Toxicogenomics, Gene Logic NANOPARTICLES. N. Garcia-Reyero1, D. S. Inc., Gaithersburg, MD. Barber1, K. Hyndman2, D. Evans2, K. Powers4, J. H. Freedman3 and N. D. Denslow1. 1Physiological #1074 REPRODUCIBILITY OF MICROARRAY Sciences, University of Florida, Gainesville, FL, ANALYSIS IN TOXICOGENOMICS STUDIES. 2Zoology, University of Florida, Gainesville, P. Ancian, S. Leuillet, R. El Gana, S. Arthaud, C. FL, 3Laboratory of Molecular Toxicology, ETP, Fisch, S. de Jouffrey and R. Forster. CIT, Evreux, DIR, NIEHS, Research Triangle Park, NC and TUESDAY France. 4Engineering, University of Florida, Gainesville, FL. #1075 COMPARATIVE TESTICULAR #1083 DOXORUBICIN STIMULATES GENE EXPRESSION PROFILING MITOCHONDRIAL BIOGENESIS AND OF 2-METHOXYETHANOL, 1, DOWNREGULATES MITOCHONDRIAL 3-DINITROBENZENE AND DI(2- GENE TARGETS. J. M. Berthiaume and K. ETHYLHEXYL)PHTHALATE IN ADULT B. Wallace. Toxicology Graduate Program, MALE RATS. E. Tonkin, S. Chanda, P. Day-Lollini, Biochemistry & Mol. Biology, University of J. Allard and S. Platz. Roche Palo Alto, Palo Alto, Minnesota, Duluth, MN. CA. #1084 GENE EXPRESSION ANALYSIS REVEALS #1076 DIFFERENTIALLY REGULATED GENES DIFFERENTIAL POLYADENYLATION OF EXPRESSION IN THE TESTIS OF ORNITHINE DECARBOXYLASE (ODC) SPRAGUE-DAWLEY RATS TREATED WITH TRANSCRIPTS IN THE KIDNEYS OF CD DI(N-BUTYL) PHTHALATE. M. Ahn, H. Kim, J. VERSUS FISCHER 344 RATS. S. Seidel, S. Ryu, H. Kim, H. Park, J. Kim and J. Im. College of Hung, H. Kan and B. B. Gollapudi. Toxicology and Pharmacy, Pusan National University, Busan, South Environmental Research & Consulting, The Dow Korea. Sponsor: I. Yu. Chemical Co., Midland, MI. up-to-date information at www.toxicology.org 143 . . , A. , 1 2 . , 1 1 , J. J. 2 , H. 1
L. Z. Shi , K. Takami , K. 2 and K. R. Ise 3 Boehringer- and R. Nagata 2 2 Q. Huang , Q. 1 , T. Matsushita T. , Annual Meeting Annual 1 and R. S. Paules 2 th T. Inoue , T. 3 , S. Asahi , S. 2 , N. Miyajima , N. 1 K. Gerrish , T. Inoue T. , , 1 1 SOT's 45 SOT's Biological Safety Research Center, Safety Research Center, Biological 3 . School of Health Sciences, Purdue Safety Assessment Department, Safety 1 , H. Fukui 2 Takeda Pharmaceutical Company Ltd., Pharmaceutical Company Takeda K. T. Blanchard T. , K. . 2 2 4 , J. Chou , J. 1 H. Suzuki , Y. Hirabayashi Y. , 2 , S. Kanazashi 1 Research Compliance and Quality Assurance Quality Research Compliance and 4
National Center for Toxicogenomics, NIEHS, Toxicogenomics, National Center for Tokyo, Shin Nippon Biomedical Laboratories, Ltd., Worldwide Safety Sciences, Pfizer Japan Inc., Worldwide Research Triangle Park, NC and Park, Triangle Research Biomed & Pharmacology Sciences, University of Sciences, University Biomed & Pharmacology Montana, Missoula, MT. SELECTION OF GENES IMPLICATED . Medicinal and Natural Products Chemistry, Doorn. Medicinal and Natural Products Chemistry, IA. City, Iowa of Iowa, The University BLOOD-CSF BARRIER VITRO IN VALID A SYSTEM FOR BRAIN TRANSPORT STUDY. TRANSPORT TOXICANT Zheng and W. IN METHAPYRILENE-INDUCED BY COMPARING HEPATOTOXICITY DIFFERENTIAL GENE EXPRESSION IN TISSUE. AND NON-TARGET TARGET 1 Izumi Horinouchi 1 Japan and Osaka, Japan. 4-DIHYDROXYPHENYLA SYNTHESIS OF 3, AS AND ITS REACTIVITY CETALDEHYDE OF DOPAMINE INTERMEDIATE TOXIC A A. Florang and J. V. Rees, N. J. METABOLISM. CELLS. I. Horii 2 Aichi, Japan, and Co., Ltd., Kamakura, Japan. AND GENE EXPRESSION HISTOLOGICAL TO AFTER EXPOSURE CHANGES IN MICE A. Putnam, M. AMPHIBOLE. E. THE LIBBY A. Smartt and M. Pershouse A. Groves, Brezinski, Chugai PharmaceuticalChugai Co., Ltd., Kamakura, Japan, University, West Lafayette, IN. Lafayette, West University, Kobayashi Auman T. S. Jayadev GENE EXPRESSION PROFILING PROFILING GENE EXPRESSION VITRO IN RAT CHEMICALS IN OF NEPHROTOXIC TUBULAR CORTICAL RENAL PRIMARY Coordination Department, Pharmaceutical Chugai National Institute of Health Sciences, Tokyo, Japan Tokyo, Sciences, National Institute of Health Ingelheim, Ridgefield, CT. DNA DEVELOPMENT OF CUSTOM FOR CYNOMOLGUS MICROARRAY DETECT EFFECTIVELY TO MONKEY OF COMPOUNDS. TOXICITY
(Continued) Annual Annual th #1093 #1096 Tuesday, March 7 March Tuesday, 12:00 NOON AM to 9:00 Exhibit Hall DISEASE MODELS SYSTEM: NERVOUS POSTER SESSION: NJ and Lewis Piscataway, Rutgers, Thiruchelvam, Chairperson(s): Mona WI. Madison, Wisconsin, of Shi, University AM–12:00 NOON 9:00 Displayed: AM AM–10:30 Attended: 9:00 #1095 #1092 #1091 #1094 45 144
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2 , , 1 1 , J. , J. , M. 4, 1 , 1 2 , S. 2 Department 2 K. T. T. and K. , G. P. Feeney , G. P. 1 1 P. Kwanyuen , P. Health Sciences, 1 1 , D. Mash , D. , K. M. Gideon Toxicogenomics, Toxicogenomics, 1 2 1 . Ophthalmology, Ophthalmology, 6 Battelle Biotech 5 , H. T. Whelan T. , H. . 2 K. D. DeSmet , K. D. 3 4 Safety Assessment, Safety Battelle Toxicology Toxicology Battelle 2 1 M. Tirmenstein , M. . 2 1 1, 4, 2 , D. Zheng , D. 1 N. Cariello , N. , R. Brown , R. Jones School of Biosciences, 1 1 2 2 . , C. Hu 1 and M. Jett . 6 Cell Biology, Neurobiology Neurobiology Cell Biology, College Medical Neurology, M. K. Lee 3 4 J. T. Eells T. J. H. ni Nutritional Sciences Research 1 and . Safety Assessment, GlaxoSmithkline, Safety 1 2 1 , D. Creech , D. , R. Das , L. Yoon , L. , M. T. Wong -Riley Wong T. , M. 1 . 5 1 2 , A. M. Brys , 1 and J. ffrench-Mullen and J. 3, 1 3 Opthalmology, Medical College of Wisconsin, Wisconsin, of College Medical Opthalmology, School of Psychology, Victoria University University Victoria School of Psychology, 2 3 Drug Safety Assessment, Sanofi-Aventis Inc., Assessment, Sanofi-Aventis Drug Safety Molecular Pathology, Walter Reed Army Institute of Army Reed Walter Molecular Pathology, MD. Inc., Gaithersburg, Genomics, Gene Logic and Anatomy, Medical College of Wisconsin, Wisconsin, of College Medical Anatomy, and WI, Milwaukee, WI, Milwaukee, Wisconsin, of Division, King’s College London, London, England, London, London, England, College King’s Division, Gene Logic Inc., Gaithersburg, MD, MD, Inc., Gaithersburg, Gene Logic R. A. Renne R. Northwest, Richland, WA and WA Richland, Northwest, TRANSCRIPTOMIC ANALYSIS OF ZINC ANALYSIS TRANSCRIPTOMIC (DANIO IN ZEBRAFISH REGULATION Research Triangle Park, NC, Park, Triangle Research 3 NJ. Bridgewater, GENE EXPRESSION PROFILING MICE TISSUES FROM IN LUNG CIGARETTE SMOKE, TO EXPOSED OR SMOKE PLUS LIPOPOLYSACCHARIDE, BY INHALATION. LIPOPOLYSACCHARIDE H. Colton M. Easton D. St. Clair Sponsor: D. MARKED SIMILARITY OF GENE INDUCED IN EXPRESSION PATTERNS THREE INHIBITORS HEPG2 CELLS BY WITH SYNTHESIS OF PROTEIN ACTION, DIFFERING MECHANISMS OF AND ANISOMYCIN CYCLOHEXIMIDE, PUROMYCIN. W. Mattes Sponsor: W. RERIO). C. Hogstrand United Kingdom and Research, Washington, DC. Washington, Research, OF COMPARISON CROSS-SPECIES COCAINE-INDUCED GENE EXPRESSION AND HUMAN IN RAT PROFILES Yoshioka HIPPOCAMPUS. M. Schenk FL, 4 University of Wisconsin-Milwaukee, Milwaukee, Milwaukee, Wisconsin-Milwaukee, of University 6 EFFECT OF NEAR-INFRARED LIGHT EFFECT OF NEAR-INFRARED INTOXICATION- THERAPY ON METHANOL GENE IN RETINAL ALTERATIONS INDUCED EXPRESSION. WI, Morgan and P. Kille and P. United Kingdom. Wales, Cardiff, University, Cardiff TARGETS SEARCH FOR MOLECULAR INDUCED OF DOXORUBICIN and R. Zemlin, S. Reymann CARDIOTOXICITY. and Toxicology Institut of . Fraunhofer Borlak J. Germany. Experimental Medicine, Hannover, VerHoeve University of Wisconsin-Madison, Madison, WI and Madison, Wisconsin-Madison, of University Q. Meng Q. Milwaukee, WI, Milwaukee, Columbus, Columbus, OH. GlaxoSmithKline Inc., Upper Merion, PA and GlaxoSmithKline Inc., Upper Merion, PA of Wellington, Wellington, New Zealand and New Wellington, Wellington, of of Neurology, University of Miami, Miami, of University of Neurology, M. Henry 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1087 #1090 #1086 #1085
#1088 #1089 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1097 PRELIMINARY CHARACTERIZATION OF #1105 MICROGLIA ACTIVATION, OXIDATIVE THE PARK7 KNOCKOUT MOUSE: A NEW IN STRESS AND NEURODEGENERATION IN VIVO MODEL FOR PARKINSON’S DISEASE. THE PARAQUAT MODEL. A. L. McCormack, A. Ashley1, W. H. Hanneman1, 2, R. B. Tjalkens1, 2 D. Bonneh-Barkay, S. H. Reaney, S. Cumine, M. G. and M. E. Legare1, 2. 1Cell and Molecular Biology Purisai and D. A. Di Monte. The Parkinson’s Institute, Program, Colorado State University, Fort Collins, Sunnyvale, CA. CO and 2Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, #1106 MECHANISM OF ACTION OF PARAQUAT CO. IS DISTINCT FROM THAT OF MPP+ OR ROTENONE IN NEUROBLASTOMA #1098 FIBRILLAR ALPHA-SYNUCLEIN CELLS STABLY EXPRESSING DOPAMINE SELECTIVELY DAMAGES DOPAMINERGIC TRANSPORTER. S. Ramachandiran, J. NEURONS IN CULTURE. S. H. Reaney1, Z. Qin2, R. Richardson and G. W. Miller. Center for L. C. Johnston1, A. L. Fink1, 2 and D. A. Di Monte1. Neurodegenerative Diseases, Emory University, 1The Parkinson’s Institute, Sunnyvale, CA and Atlanta, GA. 2University of California, Santa Cruz, CA. #1107 TOXICANT EXPOSURES AND ALPHA- #1099 DOPAMINE INDUCES APOPTOSIS AND SYNUCLEIN UP-REGULATION IN ANIMAL PROTEASOMAL INHIBITION IN A RAT MODELS OF PARKINSON’S DISEASE. M. G. DOPAMINERGIC MESENCEPHALIC CELL Purisai, A. L. McCormack, M. Isla, W. J. Langston, LINE. K. S. Zafar, S. H. Inayat-Hussain and D. Ross. L. C. Johnston and D. A. Di Monte. The Parkinson’s School of Pharmacy, University of Colorado Health Institute, Sunnyvale, CA. Science Center, Denver, CO. #1108 PROGRESSIVE NEURODEGENERATION IN A #1100 NEUROCHEMICAL CHARACTERIZATION DEVELOPMENTAL PESTICIDE-EXPOSURE OF IL-6-, TNFα- AND IL-6+TNFα-DEFICIENT BASED MODEL OF PARKINSON’S DISEASE. MICE. M. H. Goodwill, D. A. Lawrence and R. M. Thiruchelvam, J. Kochar, H. Mehta, E. K. F. Seegal. Wadsworth Center, New York State Richfield and D. A. Cory-Slechta. Department of Department of Health, Albany, NY. Environmental & OccupationalMedicine, Robert Wood Johnson Medical School - University of #1101 1-METHYL-4-PHENYLPYRIDINIUM- Medicine and Dentistry of New Jersey, Piscataway, INDUCED ALTERATIONS OF GLUTATHIONE NJ. IN IMMORTALIZED RAT DOPAMINERGIC NEURONS. D. Drechsel, L. Liang and M. Patel. #1109 MOLECULAR MECHANISMS UNDERLYING Department of Pharmaceutical Sciences, University DOPAMINERGIC CELL DEATH. Z. Xia1, W. of Colorado Health Sciences Center, Denver, CO. Choi1, H. Klintworth1, S. Hsuan1, S. Kruse2 and R. Palmiter2. 1Environmetnal and occupational Heath #1102 MODULATION OF MPTP-DEPENDENT Sciences, University of Washington, Seattle, WA and INDUCTION OF INDUCIBLE NITRIC OXIDE 2Biochemistry, University of Washington, Seattle, SYNTHASE (NOS2) IN ASTROCYTES BY WA. NOVEL DI-INDOLYLMETHANE AGONISTS OF THE PEROXISOME PROLIFERATOR- #1110 MITOCHONDRIAL THIOREDOXIN IN ACTIVATED RECEPTOR GAMMA (PPAR-γ). ROTENONE-INDUCED NEUROTOXICITY. Y. D. L. Carbone1, S. H. Safe2 and R. B. Tjalkens1. Chen1, M. Yu1, M. Aschner2, D. P. Jones3 and J. Cai1. 1Environmental and Radiological Health Sciences, 1Ophthalmology, Vanderbilt University, Nashville, Colorado State University, Fort Collins, CO and TN, 2Pediatrics, Vanderbilt University, Nashville, TN 2Veterinary Physiology and Pharmacology, Texas and 3Medicine, Emory University, Atlanta, TN. A&M University, College Station, TX. #1111 IN VIVO EFFECTS OF THE #1103 ACTIVATION OF THE PROTEASE- ORGANOCHLORINE PESTICIDE ACTIVATED RECEPTOR-1 MEDIATES THE METHOXYCHLOR ON BRAIN TUESDAY PROTECTIVE EFFECTS OF THROMBIN MITOCHONDRIAL RESPIRATION, PRECONDITIONING IN A PARKINSON’S HYDROGEN PEROXIDE PRODUCTION, DISEASE MODEL. J. R. Cannon1, 2, Y. Hua2, R. PROTEIN OXIDATION AND GENE F. Keep2, 3, T. Schallert4 and G. Xi2. 1Environmental EXPRESSION. R. Schuh1, 2, R. Gupta2, J. Flaws2 Health Sciences, University of Michigan, Ann Arbor, and G. Fiskum1, 2. 1Anesthesiology, University MI, 2Neurosurgery, University of Michigan, Ann of Maryland Baltimore, Baltimore, MD and Arbor, MI, 3Physiology, University of Michigan, Ann 2Epidemiology and Preventive Medicine, University Arbor, MI and 4Psychology, University of Texas, of Maryland Baltimore, Baltimore, MD. Austin, TX. #1104 UNIQUE EXECUTION OF NO-MEDIATED TOXICITY WITHIN NAïVE AND NGF- DIFFERENTIATED PC12 CELLS. C. Brynczka2, 1 and B. Merrick1, 2. 1NCT, NIEHS, Research Triangle Park, NC and 2Department Env Mol Toxicology, NCSU, Raleigh, NC. up-to-date information at www.toxicology.org 145 - Annual Meeting Annual th SOT's 45 SOT's and www.toxicology.org in the Exhibit
Anniversary Celebration, SOT will be giving away a total th Tuesday Afternoon Tuesday Anniversary Raffle Contest will be held in the Exhibit Hall th (Continued) ANNIVERSARY RAFFLE CONTEST ANNIVERSARY Annual Annual TH th SOT 45 of $4500 over of a $4500 period! three-day over More details and contest rules are on the SOT Annual Meeting Web site at 45 Hall on-site. risk assessment. 7 March Tuesday, Room 11A YOUR UNDERSTANDING SESSION: INFORMATIONAL ACROSS DISTRIBUTION TARGET PHARMACOLOGICAL TISSUES ANIMAL AND AND DISEASED HUMAN NORMAL Gene Logic by Presented Knowing the distribution of your samples pharmacologicalsets of normal human targetsand animal tissues withinhelps establishes which large organ(s) may be affected. humanThis tissuesanalysis in canorder beto target understand extendedproviding rapid in silico potentialverificationto across more diseasedspecificitythan 6000 human ofdiseased tissues. the drug 7 March Tuesday, 12:00 NOON to 1:30 PM Exhibit Hall Tuesday, March 7 March Tuesday, Room 11A OF THE FUNDAMENTALS SESSION: INFORMATIONAL TOXICOGENOMICS Gene Logic by Presented Specifically for those scientist who describe the need technology and the its application basics.to drug This development. In seminaraddi will 30,000 data points. 7 March Tuesday, Room 11B A SOLUTION FOR SESSION: INFORMATIONAL MANAGEMENT & DATA ANALYSIS TOXICOGENOMICS System Rosetta Resolver® by Presented an increasing expressed Pharmaceuticalcompanies have and biotechnology desire to utilize gene expression studies of in drugthe safetydevelopment. A assessment brief phase case study methods will for be utilizingpresented gene highlightingexpression data for biomarker discovery and Monday, Tuesday, and Wednesday between 12:00 NOON and Wednesday and 1:30 As PM. Tuesday, Monday, part of the 45 11:00 AM to 12:00 NOON 11:00 9:45 AM to 10:45 AM AM to 10:45 9:45 tion basic data analysis techniques will be discussed that demonstrate how to get useful information from whole genome profiling that can exceed AM to 12:00 NOON 11:00 45 146 Meeting & ToxExpo & Meeting
1, , 3 . 1, 2 J. R. , J. 1 Joint , M. M. 2 1 , H. T. T. , H. 4 Cell Biology, Cell Biology, 4 G. W. Miller W. and G. 4 Health Sciences, K. DeSmet 1
. , A. L. McCormack J. M. Hatcher J. 1 and A. Kusnecov and . 1 The Parkinson’s Institute, The Parkinson’s 3 1, 2, 3 , M. Wong-Riley , M. . 3 Civil and Environmental and Environmental Civil 4 , D. Shi , D. Neurology, Medical College of Medical College Neurology, 3 1, 2 , K. D. Pennell , K. D. 3 T. S. Guillot , T. K. Reuhl 1, 2 J. T. Eells T. and J. 3, 1 , E. Buchmann 2 Ophthalmology, Medical College of Wisconsin, Wisconsin, of Medical College Ophthalmology, 2 Center for Neurodegenerative Disease, Emory Center for Neurodegenerative 1 Rutgers University, Piscataway, NJ and Piscataway, Rutgers University, . and Occupational Health, Emory Environmental
Wisconsin, Milwaukee, WI and Milwaukee, Wisconsin, University School of Medicine, Atlanta, GA, of Medicine, School University 1 Whelan WI, University, Atlanta, GA, Atlanta, GA, University, Atlanta, GA. THERAPY FOR NEAR-INFRARED LIGHT DISEASE. PARKINSON’S 2 2 OXIDATIVE DAMAGE AND NIGROSTRIATAL NIGROSTRIATAL AND DAMAGE OXIDATIVE FOLLOWING DYSFUNCTION DOPAMINE THE ORGANOCHLORINE TO EXPOSURE PESTICIDE DIELDRIN. Richardson Neurobiology & Anatomy, Medical College of Medical College Anatomy, & Neurobiology WI. Milwaukee, Wisconsin, TARDIVE THE DRUG-INDUCED IS A DIRECT TO RELATED DYSKINESIA ON ANTIPSYCHOTICS EFFECT OF Thiffault FUNCTION? C. MITOCHONDRIAL Abbott Abbott Laboratories, A. R. Lisowski. and Yang IL. Sponsor: Y. Park, D. A. Di Monte D. Sunnyvale, CA and Sunnyvale, Milwaukee, WI, Milwaukee, Engineering, Georgia Institute of Technology, Technology, Institute of Engineering, Georgia EFFECTS OF PSYCHOGENIC STIMULATION STIMULATION PSYCHOGENIC OF EFFECTS THE INDUCTION OF MICROGLIAL ON DURING ACTIVATION AND NEURONAL AND REMYELINATION. DEMYELINATION D. Urbach-Ross D. University of Wisconsin-Milwaukee, Milwaukee, Milwaukee, Wisconsin-Milwaukee, of University Henry Graduate Program in Toxicology, University of University Toxicology, in Graduate Program Piscataway, Jersey, Medicine and Dentistry of New Sponsor: NJ. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Room 11B BIOANALYSIS CONTRACTING SESSION: INFORMATIONAL COSTING THE OF THE EVOLUTION AND STUDIES TOX FOR PROCESS SFBC International by presented and CROs by Process Contracting of bioanalysis essentially generic ANDAs. In those days it made begansense to call a in CRO and ask “How the 70’s in much studies do tox charge per tend you sample to for HPLC?” Nowadays, support of be small and often only a few hundred or samples fewer are analyzed for a given method. If the per-sample cost of bioanlaysis, including the cost of and method is validation, development compared clinical between methods be an order of magnitude. can easily methods the differences and tox #1113
#1112 Program Description Description Program #1114 9:45 AM to 10:45 AM 10:45 AM to 9:45 #1115 7 March Tuesday,
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 Tuesday, March 7 12:00 NOON to 1:15 PM 12:00 NOON to 1:30 PM Room 33 Room 6F
STUDENT IN VITRO TOXICOLOGY LECTURE: USING IN ISSUES SESSION: SAFETY ASSESSMENT OF THE MAJOR VITRO GENOMICS TECHNOLOGY TO ASSESS THE IMPACT OF HUMAN METABOLITES CHEMICALS ON CELL SIGNALING NETWORKS Chairperson(s): Rakesh Dixit, Johnson and Johnson PRD, San Diego, CA. Lecturer: Kevin Gaido, CIIT Centers for Health Research, Research Triangle Park, NC. Round-Table Discussion Panel Members: Rakesh Dixit, Johnson & Johnson PRD, San Diego, CA. Sidney Nelson, University of Washington, Sponsored by: Seattle, WA. Alfred Tonelli, Johnson and Johnson PRD, Raritan, NJ. Martin The Colgate-Palmolive Company David Green, U.S. FDA, Rockville, MD. Andrew Parkinson, XenoTech, Animals in Research Committee Lenexa, KS.
Each year the Colgate-Palmolive Company invites all Metabolites can be responsible for the desired efficacy as well as the students and post-doctoral fellows at the SOT Annual adverse effects. While qualitatively both phase I and phase II metabolic Meeting to attend a luncheon and lecture concerning reactions are fairly conserved across laboratory safety species and humans, alternative research methods at the forefront of toxi- there are often important quantitative differences in the rate and the cology, specifically, methods that address reduction extent of metabolism between safety species and humans. If a metabolite of use or replacement of whole animals, or the refine- is responsible for toxicity, the quantitative differences in exposure to a ment of experimental techniques using whole animal major toxic metabolite between humans and laboratory animals can lead models. Past recipients of all the Colgate-Palmolive to misrepresentation of safety margins based on the parent drug exposure. SOT awards will be special guests. Non-clinical safety assessment studies are critical to identifying poten- tial toxicity signals for humans and for providing a reasonable assurance Students register for this event on the Annual Meeting Registration Form. related to the test drug’s safety at proposed clinical doses. Given the use A $5 deposit per ticket is required and will be returned at the luncheon of high doses (large multiples of the projected human doses) in safety upon presentation of the ticket. Seating is limited. studies and the fact that the rates of most phase I and phase II reactions are relatively greater in non-clinical safety species than in humans, it is The lecture will review an important application of in vitro toxicology to expected that in the vast majority of cases there will be adequate coverage the study of basic mechanistic processes and provide examples of how of metabolites both qualitatively and quantitatively in safety studies. In a new test methods have benefited animal welfare by refining experimental small number of cases, when the major vs. minor pathways of metabolism procedures and reducing animal use. Recent developments in genomics are dissimilar across species, there may be human specific “unique” or technology now allow for the comprehensive screening of the impact “dominant metabolites” that may not have been be adequately tested in of chemicals and pharmaceuticals on complex cell signaling networks non-clinical safety studies. without the use of whole animal systems. The high-throughput require- ment of these approaches necessitates use of in vitro cell culture systems. The U.S. Food and Drug administration has recently issued “Guidance These high throughput screens provide enormous amounts of data in for Industry: Safety Testing of Drug Metabolites.” The document makes the context of mechanistic and predictive toxicology. The tools for this a serious regulatory attempt to define the major human metabolite(s) and type of research include a combination of receptor-based reporter gene provides scientific guidance on the safety testing of the major human assays, gene expression analysis using genome-wide microarrays and metabolites in non-clinical studies. However, the guidance document has large-scale, loss-of-function and gain-of-function studies using inhibitory also raised ambiguity and concerns regarding the definition of the major RNA libraries and libraries of full-length genes, respectively. From results metabolites as well as the extent of safety studies with human dominant or obtained with these tools, a cell signaling pathway can be constructed and unique metabolites. The round-table discussion will provide an academic, a more comprehensive and mechanistic understanding of the impact of industrial and federal regulatory perspective on the proposed guideline, chemicals on biological systems can be developed. Elucidation of signaling including the definition of the major metabolite and the safety testing of pathways at the cellular level is not possible in intact animals and iden- the major metabolites. It is hoped that this scientific round-table discussion tification of mode of action at the molecular level is often important in will provide a path forward for an adequate testing the safety of metabo- explaining disease states or toxicities identified in vivo. lites. TUESDAY Tuesday, March 7 • Introduction on the Safety Assessment of the Major Metabolites, 12:00 NOON to 1:30 PM Rakesh Dixit, Johnson and Johnson PRD, San Diego, CA. Marriott Hotel & Marina • An Academic Perspective on the Safety Testing of the Major Cardiff Room Metabolites, Sidney Nelson, University of Washington, Seattle, WA. SPECIAL INTEREST GROUP MEETING/RECEPTION: HISPANIC ORGANIZATION FOR TOXICOLOGISTS • An Industry Perspective on the Safety Testing of the Major Metabolites, Alfred Tonelli, Johnson and Johnson, PRD, Raritan, NJ. • The U.S. FDA Regulatory Perspective and the Rationale for the Guideline, M. David Green, U.S. FDA, CDER, Rockville, MD. Questions/Answers: Audience
up-to-date information at www.toxicology.org 147 - -
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R. S. Pollenz Marine and 2 Annual Meeting Annual th C. N. Giroux C. N. and D. N. Weber N. and D. 1, 2 SOT's 45 SOT's , M. L. Rise 1, 2 Biology, University of South Florida, Tampa, FL. Tampa, Florida, of South University Biology, ARYL ELEGANS THE C. FOR ROLES HOMOLOG IN RECEPTOR HYDROCARBON THE IN AND DEVELOPMENT NEURONAL OF SPECIFIC BEHAVIORS. REGULATION Lakes WATER Institute, University of Wisconsin- of Institute, University WATER Lakes WI and Milwaukee, Milwaukee, Carvan AND PREDICTION OF MECHANISMS OF TOXICITY. CELLULAR SIGNATURES OF EXPOSURE AND OF EXPOSURE SIGNATURES YEAST A OF SUSCEPTIBILITY: PATHWAYS FOR BIOMARKER DISCOVERY TOOLKIT of Environmental Health Sciences, Wayne State Wayne Health Sciences, of Environmental Detroit, MI. University, UNDERSTAND TO USING ZEBRAFISH THE EFFECTS OF DEVELOPMENTAL THE AND EXPOSURE METHYLMERCURY DIET. INFLUENCE OF MATERNAL Freshwater Biomedical Sciences Center, University University Biomedical Sciences Center, Freshwater WI. Milwaukee, Wisconsin-Milwaukee, of ALTERNATIVE MODEL ORGANISMS FOR ALTERNATIVE AND OF DEVELOPMENTAL ANALYSIS THE TOXICOLOGY. MOLECULAR J. A. Powell-Coffman and H. Qin. Genetics, and H. Qin. A. Powell-Coffman J. State Iowa and Cell Biology, Development, Ames, IA. Sponsor: R. Pollenz University,
SS (Continued) Annual Annual th Reproductive and Development SS and Development Reproductive In Vitro In Mammalian organisms have long been but a in staple recent of yearstoxicology there researchhas non-mammalian been modelsa significantsystems in increasemolecular inand thedevelopmental use toxi of #1117 1:35 1:30 PM to 4:30 PM Room 5B MODEL ORGANISMS ALTERNATIVE SYMPOSIUM SESSION: AND MOLECULAR OF DEVELOPMENTAL ANALYSIS THE FOR TOXICOLOGY Tampa, of South Florida, University S. Pollenz, Chairperson(s): Richard MI. Detroit, State University, Wayne Giroux, FL and Craig by: Endorsed #1118 2:10 #1119 2:45 Tuesday, March 7 March Tuesday, cology. Alternative model cology. organisms that are in current use include yeast, invertebrates such as Drosophila and Caenorhabditis models elegans, such as vertebrateDanio rerio (zebrafish) and Xenopus, and the pant model, Arabadopsis. The analysis of toxicologically relevant endpoints organismsin thesehas several advantages over traditionalFirst, mammalian manysystems. toxicologically of relevantthese organismspathways that recapitulateare genomes these Second, are organisms externally develop expressedand available. the the mammalian in pathways eachand full process proceeds Thisrapidly. makes it possible to observe development in real-time. Third, due to the size of the organisms, large numbers can be many Finally, possible. studies screening throughput high making evaluated of these organisms banks have of defined mutants that can be manipulated to directly assess protein interactions and molecular gene tools regulation.continue to Thus, be asadvanced for the each of utility these in many aspects systems, of toxicology is This unlimited. their session is designed to highlight the use of models alternative in the of analysis signal transduc and genomics. development, tion pathways, #1116 1:30 45 . 148 - - - - Meeting & ToxExpo & Meeting
in vitro
45th Annual Meeting and ToxExpo and Meeting Annual 45th
TOXICOLOGY TOXICOLOGY VITRO IN Inc. Cellnomics, by Presented Cellomics Inc., provider systems, of invites you integratedto attend this cellularinformational session contenton imaginguse analysis of (HCA) high- to andperform analysispredictive toxicology assays Room 11B BIOMARKERS AND NOVEL NEW SESSION: INFORMATIONAL TESTING IN NEPHROTOXICITY Biotrin International by Presented Urinary biomarkers that reveal injury to specific parts of the nephron can lead to earlier, more sensitive identification of be nephrotoxicity. presented Data on will novel biomarkers for the proximal and distal tubules convoluted and the renal papillary collecting ducts and their use in nephrotox 1:30 PM to 2:30 PM 1:30 PM to 2:30 PM Room 11A AND GENECHIP® MICROARRAYS SESSION: INFORMATIONAL ONE TOXICOGENOMICS—PART THEIR USE IN Affymetrix by Presented Affymetrix GeneChip® products enable toxicologists to understand mech 12:15 PM to 1:15 PM Room 11B SOLUTIONS TOXICOGENOMICS SESSION: INFORMATIONAL TECHNOLOGY BEADARRAY USING ILLUMINA’S Illumina by Presented Illumina offers toxicologists a complete solution for expression profiling, from whole genome to focused gene set arrays in human, mouse and This rat. informational session will demonstratequality how andindustry-leading cost data per sampleformats enable coupledmore robustwith experimentalunique designs multi-sampleand simplified arraywork Tuesday, March 7 March Tuesday, Room 11A FOR ASSAYS HIGH-CONTENT SESSION: INFORMATIONAL of the An platform overview genetic and toxicity, its use for hepatotoxicity, be shown. will and neurotoxicity Tuesday, March 7 March Tuesday, 12:15 PM to 1:15 PM icity testing. Come Nephro-Navigate with Biotrin. icity testing. Come Nephro-Navigate Tuesday, March 7 March Tuesday, 7 March Tuesday, flows. anisms of toxicological response, discover new biomarkers predictive toxic outcomes, and of understand gene expression changes occurring within This cellular seminar pathways. will highlight the basic principals of using GeneChip technology for toxicogenomic research and is designed to help accelerate your studies. toxicogenomic See page 178 for GeneChip Micro Two. Toxicogenomics—Part Their Use in and arrays Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1120 3:20 USING ZEBRAFISH TO UNRAVEL THE #1124 2:20 THE ROLE OF KUPFFER CELLS IN MECHANISM OF DITHIOCARBAMATE IMMUNE-MEDIATED ADVERSE DRUG DEVELOPMENTAL TOXICITY. R. L. Tanguay1, REACTIONS. C. Ju1, Q. You1, L. Cheng1 and T. F. Tilton1, J. K. LaDu1, K. R. Svoboda2, H. Teraoka3 P. Reilly2. 1Pharmaceutical Sciences, University of and T. Hiraga3. 1Environmental and Molecular Colorado Health Sciences Center, Denver, CO and Toxicology, Oregon State University, Corvallis, OR, 2Drug Safety Evaluation, Bristol-Myers Squibb, 2Biological Sciences, Louisiana State University, Syracuse, NY. Baton Rouge, LA and 3Department of Toxicology, Rakuno Gakuen University, Ebetsu, Japan. #1125 2:50 ROLE OF THE KUPFFER CELL IN MODULATION OF HEPATIC #1121 3:55 A NEMATODE MODEL TO ELUCIDATE PRENEOPLASTIC LESION GROWTH. L. MECHANISMS OF DEVELOPMENTAL M. Kamendulis and J. E. Klaunig. Department of TOXICITY. D. Jackson1, J. Lewis1, S. Anderson4, Pharmacology and Toxicology, Indiana University E. Gehman3, M. Szilagyi2 and E. Clegg1. 1US Army School of Medicine, Indianapolis, IN. Center for Environmental Health Research, Fort Detrick, MD, 2U.S. EPA, Washington, DC, 3Gold #1126 3:20 KUPFFER CELL ACTIVATION BY NON- Belt Raven, Inc., Fort Detrick, MD and 4Geo- GENOTOXIC CHEMICALS: DOES IT PLAY Centers, Inc., Fort Detrick, MD. A ROLE IN HEPATOCARCINOGENESIS? I. Rusyn and C. Woods. University of North Carolina at Chapel Hill, Chapel Hill, NC. Tuesday, March 7 1:30 PM to 4:30 PM #1127 3:50 ROLE OF THE KUPFFER CELL IN Room 6C MEDIATING THE RESPONSE OF THE LIVER TO LIGANDS FOR PPARα R. Roberts. Safety SYMPOSIUM SESSION: ROLE OF THE KUPFFER CELL IN Assessment, AstraZeneca, Macclesfield, United MEDIATING HEPATIC TOXICITY AND CARCINOGENESIS Kingdom.
Chairperson(s): James Klaunig, Indiana University, Indianapolis, IN and Tuesday, March 7 Ruth Roberts, AstraZeneca UK, Macclesfield, United Kingdom. 1:30 PM to 4:30 PM Endorsed by: Room 8 Carcinogenesis SS* SYMPOSIUM SESSION: USING STRUCTURE-BASED This symposium will address the role of the Kupffer cell, the resident APPROACHES FOR HAZARD IDENTIFICATION AND RISK macrophage of the liver, in the induction and/or facilitation of acute and ASSESSMENT chronic liver injury. The Kupffer cell plays an important role in the normal physiology and homeostasis of the liver both as well as participating in the Chairperson(s): Nigel Greene, Pfizer Global Research & Development, acute and chronic responses of the liver to toxic compounds. Activation of Groton, CT and Robert Kavlock, U.S. EPA, Research Triangle Park, NC. Kupffer cells directly or indirectly by toxic agents results in the release of Endorsed by: an array of inflammatory and growth control mediators as well as reactive Biological Modeling SS oxygen species. This activation appears to modulate acute hepatocyte injury Regulatory and Safety Evaluation SS* as well as chronic liver responses including hepatic cancer. Understanding Risk Assessment SS the role the Kupffer cell plays in the induction of hepatocyte injury is essential in understanding the mechanisms of the liver injury. Idiosyncratic Social demands to ensure public health and safety from either planned or drug induced liver disease results in morbidity and mortality and has been a accidental exposure to new molecular entities whilst still maintaining a major detriment to new therapeutic pharmacological development. Modula- flow of new and more effective medicines or the necessary commercial tion of the Kupffer cell response by drugs has been suggested as a cause for advances in personal products, requires both industry and regulatory the idiosyncratic response. Similarly, liver damage seen in chronic ethanol authorities to identify and manage the risks presented by an increasingly consumption appears to be modulated by Kupffer cell activation. More large number of novel compounds. Often these initial assessments are recent evidence has noted a contributory role of Kupffer cell activation in made in the absence of high quality toxicology data and generating this the process of hepatic carcinogenesis. Several nongenotoxic carcinogens, data would take many years and millions of dollars for each compound TUESDAY for example, activate Kupffer cells which results in the release of cytokines under review. As a result, the scientific community has been seeking and/or reactive oxygen species that induce hepatocyte cell proliferation and ways to prioritize these new and existing chemical entities according to may enhance clonal expansion of preneoplastic cells leading to neoplasia. their potential for adverse effects to either humans or the environment. The Kupffer cell therefore appears to play a central role in the hepatic Structure-based approaches to hazard identification and risk assessment response to toxic and carcinogenic agents. (Supported by NIH CA100908) offer significant advantages for both industry and regulator alike but their #1122 1:30 ROLE OF THE KUPFFER CELL IN application is not without its drawbacks. On the positive side, these types MEDIATING HEPATIC TOXICITY AND of approaches to hazard assessment are very fast and cheap to run once CARCINOGENESIS. J. E. Klaunig. Pharmacology they have been successfully implemented. In addition, these approaches and Toxicology, Indiana University, Indianapolis, IN. offer a highly attractive public relations solution in view of the increasing demands to refine, reduce or replace animals in laboratory experiments. #1123 1:50 THE CONTRIBUTION OF KUPFFER However, questions still exist about their ability to accurately distinguish CELL-DERIVED MEDIATORS TO between toxic and non-toxic molecules and their effectiveness in ensuring 1, 2 ACUTE HEPATOTOXICITY. P. E. Ganey . public safety. This symposium will highlight recent experiences and learn- 1 Pharmacology and Toxicology, Michigan State ings in the practical application of structure-based hazard identification 2 University, East Lansing, MI and Center for and/or risk assessment across a broader scope of industry and regulatory Integrative Toxicology, Michigan State University, agencies. The presentations will illustrate how structure-based assessments East Lansing, MI. are being applied towards a variety of potential hazards (genetic toxicity, up-to-date information at www.toxicology.org 149
- - - S. . M. W. M. W. . and 1 Annual Meeting Annual Pulmonary and Critical th 2 . VM-APC, VM-APC, Plopper. C. G. D. K. Bhalla D. SOT's 45 SOT's Fund/Appl. Sciences., Wayne State Wayne Fund/Appl. Sciences., 1 . 2 Durham, NC. WHERE DOES INHALED OZONE GO? J. OZONE EXPOSURE. CA. of California, Davis, University MECHANISMS IN OZONE INFLAMMATORY THE LUNG. IN INDUCED MUCOSAL INJURY Tager. PHYSIOLOGICAL PERSPECTIVE. I. B. of. California Health, Universtiy School of Public Bhalla CA. Sponsor: D. Berkeley, Berkeley, Ultman, L. Y. Santiago, A. Fassih and A. Ben-Jebria. and A. Fassih Santiago, Y. Ultman, L. State University, Chemical Engineering, Penn Bhalla Sponsor: D. PA. Park, University EARLY POSTNATAL LUNG DEVELOPMENT POSTNATAL EARLY PERMANENT TO SUSCEPTIBLE IS HIGHLY STRESS FROM BY OXIDANT DISRUPTION . Pulmonary & Critical Care Medicine, Duke Foster Durham, NC. Medical Center, University AMBIENT EFFECTS OF HUMAN HEALTH AND EPIDEMIOLOGICAL OZONE: THE WAR ON OZONE IN THE 3RD ON OZONE IN WAR THE AND HEALTH TOXICOLOGY MILLENNIUM: EFFECTS UPDATE. . Fund/Appl. Sciences., Wayne State Wayne K. Bhalla. Fund/Appl. Sciences., D. Detroit, MI. University, LABORATORY LESSONS LEARNED FROM OZONE: TO EXPOSURE OF HUMANS DIFFERENTIAL SUSCEPTIBILITY. Care Medicine, Duke University Medical Center, Medical Center, University Care Medicine, Duke University, Detroit, MI and University, W. Foster W.
(Continued) Annual Annual th #1135 1:35 #1137 2:45 #1136 2:10 #1139 3:55 inducedduring the initial exposure is likely to be modified subsequentby exposures. This is presumptive, but based upon the potential for cells and tissues injured during the initial insult to become less,more, susceptibleor perhaps to additionaleven injury by a subsequent insult. As a nisticmecha explanation for lung injury, O3 and other air pollutants to are reactknown with cell membranes within directthe responserespiratory throughtract oxidative and actions. initiateThe mechanisms,destructiona either of protectiveby a direct action the of oxidantseffects in theof airinflammatory or throughaltered susceptibility mediators, to complex atmospheres offersor upon repeatEpidemiologicalan exposures.studiesexplanation have also identified greater forvulnerability the of sen sitive populations, such as the children, the elderly andcardiopulmonary individuals with conditions, to air pollutants.ozone levels in theIt air is substantiallysuggested increase thatthe risk high of illnessfor and compromiseddeath individuals. Clearly, the of role air of pollutionozone incan thenot toxicitybe ignored.air A qualityneed for standardsreevaluation of for currentinterestozone in is understandingrecognized, its contributionand to lungthere the disease. development is Withof achronic ozone growingas the focus, abovethe issues,symposium willby addressdiscussing the ozonethe dosimetry,respiratory developmentalsystem, cellular statusand injury,inflammatory humanof health effects, sensitivitymechanisms of susceptible populations, of lungmod ification of particle toxicity in mixed atmospheres and future directions. #1134 1:30 #1138 3:20 45 150 - - - Meeting & ToxExpo & Meeting . . 2 , M. O. , M. O. 1
Molecular 2 K. L. Dobo . Genetic Toxicology, Toxicology, Genetic 1 . . 1 R. J. Kavlock and R. J. 1 N. Greene N. W. W. Ku W. and W. 2 . Office of Pharmaceutical Contrera F. and J. National Center for Computational Toxicology, Toxicology, National Center for Computational N. Greene , N. 2 1
Safety Sciences Groton, PfizerSafety Sciences Groton, CT Inc., Groton, National Center for Computational Toxicology, U.S. U.S. Toxicology, National Center for Computational NC. Park, Triangle Research EPA, THE GENOTOXIC ASSESSMENT OF OF PHARMACEUTICAL POTENTIAL IMPURITIES USING STRUCTURE-BASED LEVEL PRIORITIZING LOW METHODS: AND MEASUREMENT ANALAYTICAL OF IMPURITIES. CONTROL Science, Food and Drug Administration, Rockville, and Drug Science, Food MD. THE USE OF STRUCTURE ACTIVITY ACTIVITY THE USE OF STRUCTURE IN SKIN (SAR/ QSAR) RELATIONSHIPS S. P. ASSESSMENT. RISK SENSITIZATION Strombeek-Bever, Eurocor, Procter Gamble Kern. R. Benz F. Gerberick Belgium. Sponsor: F. EMERGENCE OF (Q)SAR DECISION IN FDA INFORMATION SUPPORT L. Kruhlak, N. Matthews, E. J. APPLICATIONS. N. Greene Switzerland. Sponsor: N. Cyr and Investigative Toxicology, Pfizer Global R &D, Pfizer Global R &D, Toxicology, and Investigative Groton, CT. FOR USING STRUCTURE A STRATEGY (SAR) FOR RELATIONSHIPS ACTIVITY AND SAFETY PHARMACOLOGY TOXICITY L. Mueller. R&D. IN PHARMACEUTICAL Roche Ltd., Basel, Hoffmann-La F. PRBN-T, 1 and USING STRUCTURE-BASED APPROACHES APPROACHES USING STRUCTURE-BASED AND RISK FOR HAZARD IDENTIFICATION ASSESSMENT. U.S. EPA, Research Triangle Park, NC. Park, Triangle Research EPA, U.S. APPROACHES AND CHALLENGES PRIORITIES FOR ESTABLISHING HAZARDS FOR AND CATEGORIZING Kavlock R. J. S. EPA. THE U. CHEMICALS BY Pfizer Groton, CT and D, Global R &
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Occupational and Public Health SS Occupational and Public Inhalation SS* Immunotoxicology SS Immunotoxicology Although airborne PM has received considerable to attentionhealth effects,with respectozone remains a major toxic component of the photo #1130 2:10 Tuesday, March 7 March Tuesday, #1132 3:20 : Deepak Bhalla, Wayne State University, Detroit, MI and Detroit, State University, Wayne Chairperson(s): Deepak Bhalla, Durham, NC. Medical Center, Duke University Foster, Michael W. by: Endorsed Room 6F THE 3RD ON OZONE IN WAR THE SYMPOSIUM SESSION: EFFECTS UPDATE AND HEALTH TOXICOLOGY MILLENNIUM: 1:30 PM to 4:30 PM #1131 2:45 carcinogenicity, skin carcinogenicity, sensitization, etc.) and how this information is being used to aid in decision-making (e.g. development, risk management, expo chemical smog. It is generally recognized that the properties and potency of individual toxicants may be modified upon their combination inplex com atmospheres. Furthermore, in chronic exposures, a lung response
sure controls, prioritization of biological testing). of biological sure controls, prioritization #1128 1:30 Program Description Description Program #1133 3:55 #1129 1:35
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 Tuesday, March 7 1:30 PM to 4:30 PM 1:30 PM to 4:30 PM Room 6D Room 6B
WORKSHOP SESSION: DENDRITIC CELLS AND SKIN WORKSHOP SESSION: GENOMICS IN RISK ASSESSMENT: SENSITIZATION: BIOLOGICAL ROLES AND USES IN HAZARD UTILITY FOR THE CHARACTERIZATION OF MODE OF IDENTIFICATION ACTION
Chairperson(s): G. Frank Gerberick, Procter & Gamble Company, Chairperson(s): Ines Pagan, U.S. EPA, Research Triangle Park, NC and Cincinnati, OH. Douglas Wolf, U.S. EPA, Research Triangle Park, NC.
Endorsed by: Endorsed by: Dermal Toxicology SS* Regulatory and Safety Evaluation SS In Vitro SS Risk Assessment SS* Occupational and Public Health SS Toxicologic and Exploratory Pathology SS Women in Toxicology SS The purpose of this Workshop is to describe advances that have been made in recent years in our understanding of the roles played by cutaneous Microarray technologies promise to greatly enhance our ability to describe dendritic cells in the induction of contact allergy. In addition, the ways pathophysiological processes, including toxicant-induced responses. in which such advances in dendritic cell biology have been exploited to Differential gene expression after exposure to a toxicant will allow for develop alternative approaches to the identification and characterization of the determination of potential biomarkers of toxicity. These array-based skin sensitizing chemicals will be presented. biomarkers should enable the detection of changes at a very early stage in #1140 1:30 DENDRITIC CELLS AND SKIN the progression of toxicant-induced adverse health effects. The realization SENSITIZATION: BIOLOGICAL ROLES of these promises, however, depends on careful validation, statistical anal- AND USES IN HAZARD IDENTIFICATION. ysis, and corroboration of genomic responses with responses in the intact G. Gerberick1 and I. Kimber2. 1Procter & Gamble, organism. Thus, new informatics and analytical methods as well as large Cincinnati, OH and 2Syngenta, Macclesfield, United integrated databases are being developed to interpret the vast amount of Kingdom. biological data and turn it into useful information. Although these technol- ogies are in the developmental stages, both the U.S. EPA and the USFDA #1141 1:35 LANGERHANS CELLS, CYTOKINES, have developed draft guidances and policies that recognize that these data INDUCTION OF SKIN SENSITIZATION, will ultimately be part of science-based safety and risk assessment deci- AND ITS MODIFICATION. K. Cooper1, 2, 3. sions. Initially, genomic data shows promise in the characterization of 1Dermatology, Case Western Reserve University, chemical-specific mode of action (MOA) and in the description of toxicity Cleveland, OH, 2University Hospitals of Cleveland, pathways that result in adverse health effects. This workshop will present Cleveland, OH and 3VA Medical Center, Cleveland, potential approaches on how genomics could be used to fill data gaps in OH. Sponsor: F. Gerberick. the characterization of the MOA used in the assessment of risk posed by environmental chemicals. #1142 2:10 GENE EXPRESSION CHANGES INDUCED IN CULTURED DENDRITIC CELLS BY #1146 1:30 GENOMICS IN RISK ASSESSMENT: UTILITY CHEMICAL ALLERGENS. L. A. Gildea. FOR THE CHARACTERIZATION OF MODE Corporate Biotechnology, Procter & Gamble, OF ACTION. I. Pagan and D. C. Wolf. U.S. EPA, Cincinnati, OH. Sponsor: G. Gerberick. Research Triangle Park, NC. #1143 2:45 APPROACHES TO SKIN SENSITIZATION #1147 2:00 THE ROLE OF MODE OF ACTION HAZARD IDENTIFICATION USING INFORMATION IN HUMAN HEALTH RISK CULTURED DENDRITIC CELLS. M. J. ASSESSMENT. V. Dellarco. U.S. EPA, Washington, Pallardy, D. Antonios, F. Boisleve and S. Kerdine. DC. Toxicologie, Faculte Pharmacie, University Paris- #1148 2:30 INTEGRATION OF GENOMICS WITH Sud, Chatenay-Malabry, France. TRADITIONAL TOXICOLOGY. G. Boorman. #1144 3:20 RING TRIALS OF DENDRITIC CELL NIEHS, Research Triangle Park, NC. TUESDAY SURROGATE CELL LINES. C. Ryan. Procter & #1149 3:10 DEFINING TOXICOLOGICAL PATHWAYS Gamble Company, Cincinnati, OH. FROM INDIVIDUAL BIOMARKERS: #1145 3:55 DISCUSSION: THE WAY FORWARD. D. A. IDENTIFICATION OF TECHNOLOGIES Basketter2, G. Gerberick1 and I. Kimber3. 1Procter AND TOOLS CRITICAL IN MOLECULAR 1, 2 1 & Gamble, Cincinnati, OH, 2Unilever, Sharnbrook, RISK ASSESSMENT. A. Brooks . University of United Kingdom and 3Syngenta, Macclesfield, Medicine and Dentistry of New Jersey, Piscataway, 2 United Kingdom. NJ and Rutgers University, Piscataway, NJ. Sponsor: D. Wolf. #1150 3:50 BIOLOGICAL PLAUSIBILITY AND APPLICATION TO RISK ASSESSMENT: HUMAN RELEVANCE AND DOSE- RESPONSE ANALYSIS. C. J. Borgert1, 2. 1Applied Pharmacology and Toxicology, Inc., Gainesville, FL and 2University of Florida College of Veterinary Medicine, Gainesville, FL. up-to-date information at www.toxicology.org 151 .
S. ,
γ 3 , . 3 , A. , , V. V. , 1, 2 1 , A. N. A. N. , 1 Chemistry S. Baek V. and V. 1 , 2 . 2
3 , J. Sandhu , J. 2 Annual Meeting Annual th , J. Vergel de Dios Vergel , J. Institute for Biological Institute for Biological , S. Papineni , I. V. Kurnikov V. , I. 1 3 , J. Cohen , J. 1 1 2 , D. Stoyanovski , D. M. Deshmukh. Cell and Department of Biochemistry 1 1 and M. Sikorska Department of Pathobiology, Department of Pathobiology, . 3 3 1, 2, 4 SOT's 45 SOT's Psychology, University of Windsor, Windsor, of University Psychology, 2 Department of Veterinary Physiology Physiology Veterinary Department of 2 Center for Free Radical & Antioxidant Antioxidant Radical & Center for Free 1 , M. Somayajulu , A. A. Kapralov A. , . 1 1 1 Surgery, University of Pittsburgh, of Pittsburgh, University Surgery, S. Chintharlapalli , M. Potapovich 2 1 and S. Safe , V. Parameswarann V. , 4 2 Institute of Biosciences and Technology, Texas Texas Technology, Institute of Biosciences and Windsor, ON, Canada and ON, Windsor, Osipov and Biophysics, Texas A&M University, College College A&M University, Texas and Biophysics, TX, Station, PROBLEMS FOR RISK ASSESSMENT OF FOR RISK PROBLEMS THE DIET. COMPOUNDS IN ESTROGENIC & Biochemistry, University of Windsor, Windsor, Windsor, Windsor, of University & Biochemistry, Canada, ON, Burdock Group, Washington, DC. Washington, Burdock Group, COLON DECREASE HCT-116 BUT AGONISTS THROUGH CANCER CELL SURVIVAL ACTIVATION RECEPTOR-INDEPENDENT AND RESPONSE-1 GROWTH OF EARLY NAG-1. TX. System, Houston, A&M University OF AND NITROSYLATION BINDING OF NO C/CARDIOLIPIN COMPLEX CYTOCHROME AND ACTIVITY INHIBITS ITS PEROXIDASE Vlasova I. I. CARDIOLIPIN OXIDATION. E. Kagan PARAQUAT INDUCES OXIDATIVE STRESS, STRESS, INDUCES OXIDATIVE PARAQUAT AND LOSS IN SN REGION NEURONAL NEURO- IN RATS: PARKINSONISM OF AMELIORATION AND PROTECTION COQ10. WATER-SOLUBLE BY SYMPTOMS S. Pandey Matei Sciences, National Research Council of Canada, Canada. ON, Ottawa, S. Liu 4 Kramarik Carolina, Chapel Hill, NC. Sponsor: J. 1, 1-BIS(3’-INDOLYL)-1-(P-SUBSTITUTED 1, ARE PEROXISOME PHENYL)METHANES RECEPTOR PROLIFERATOR-ACTIVATED . Veterinary Physiology & Pharmacology, Texas Texas & Pharmacology, Physiology Veterinary . Safe TX. Station, College A&M University, THE ENDOCRINE DISRUPTORS SHOULD IN FOODS/COSMETICS TOLERATED BE A. Burdock LEVELS? G. WHAT AT IF SO, AND, and Pharmacology, Texas A&M University, A&M University, Texas and Pharmacology, TX, Station, College of North University Biology, Developmental H. Borowy-Borowski University of Tennessee, Knoxville, TN and Knoxville, Tennessee, of University Pittsburgh, of Pittsburgh, Health, EOH, University and PA PA. Pittsburgh, REGULATION APOPTOSIS INCREASED CELLULAR WITH POSTMITOTIC DIFFERENTIATION. A. Tyurin A.
(Continued) Annual Annual th #1155 3:20 Tuesday, March 7 March Tuesday, #1158 1:50 #1160 2:30 1:30 PM to 4:30 PM Room 1B APOPTOSIS SESSION: PLATFORM PA. Pittsburgh, of Pittsburgh, University Kagan, Valerian Chairperson(s): #1157 1:30 #1156 3:55 #1159 2:10 45 152 - -
1 Meeting & ToxExpo & Meeting . in vitro .
M. Soni
European Food European Food 2 Independent Consultant, 1 . 1, 2 Burdock Group, Vero Beach, Vero Burdock Group, 1
. 2 .
M. Soni Global Safety Department, L’oreal Research Global Safety Department, L’oreal 2 Worldwide Safety Evaluation, L’oreal R&D, R&D, L’oreal Safety Evaluation, Worldwide France. Asnieres, Cedex, OESTROGENIC CHEMICALS IN OESTROGENIC AND BREAST CANCER. COSMETICS Sponsor: G. J. Nohynek J. and G. FL and Brighton, United Kingdom and PRESERVATIVES AND ULTRAVIOLET AND ULTRAVIOLET PRESERVATIVES WITH SLIGHT ESTROGENIC FILTERS IS USED IN IN COSMETICS: ACTIVITY Nohynek J. RISK? G. HEALTH A THERE P. Darbre. School of Biological Sciences, The Sciences, Darbre. School of Biological P. of Reading, Reading, United Kingdom. University and Development, 92600 Asnieres, France. 92600 and Development, AND OF OESTROGENIC ASSESSMENT RISK IN FOOD SUBSTANCES ANTI-ANDROGENIC THE EUROPEAN IN ARTICLES CONTACT S. M. Barlow UNION. POTENTIAL HUMAN HEALTH RISK FROM RISK FROM HUMAN HEALTH POTENTIAL AND CONSUMER FOOD ESTROGENIC MUCH IS ADDITIVES- HOW PRODUCT Soni MUCH IS HYPE? M. G. AND HOW REAL Safety Authority, Parma, Italy. Sponsor: Parma, Italy. Authority, Safety
45th Annual Meeting and ToxExpo and Meeting Annual 45th
assays. As these chemicals are widely and increasingly used,
Reproductive and Development SS and Development Reproductive Risk Assessment SS Risk Regulatory and Safety Evaluation SS Evaluation Regulatory and Safety Food Safety SS* Safety Food In recent years, decreased sperm count and increased breast have claimed cancer to rates be associated with man-made and dietary (phyto-) estro #1153 2:10 : Madhu Soni, Burdock Group, Vero Beach, FL. Beach, Vero Group, Chairperson(s): Madhu Soni, Burdock by: Endorsed Room 2 RISK HUMAN HEALTH POTENTIAL SESSION: WORKSHOP AND CONSUMER PRODUCT FOOD ESTROGENIC FROM HYPE? MUCH IS AND HOW MUCH IS REAL HOW ADDITIVES: Tuesday, March 7 March Tuesday, 1:30 PM to 4:30 PM #1154 2:45 #1152 1:35 trated/ purified form. The current risk assessment of estrogenic substances as food additives is performed individually and combined effects of these substances in the diet are As not these known. substances share a common mechanism of action, an aggregate risk assessment for the each groupchemical in and a cumulative risk assessment contributionsis needed. ofAdditionally, the ingredients with antiestrogenic needsactivity due in considerations.the dietShould alsothe estrogenic levels? substancesfoods/consumer products and if so at what be added to #1151 1:30
gens. Several additives used gens. additives in Several foods and other consumer products, such as UV isoflavones, screens, certain A, alkylphenols, bisphenol some parabens and certain phthalates have been shown to be estrogenic weakly in or in vivo Program Description Description Program there is a growing concern as to Recent findingsbreast cancer. on the presence of parabens in theirhuman breast role in reproductive toxicity and ignited the debate cancer on tissue the samples food role have of estrogenic additives in the development of cancer and findingsreproductive and toxicity. These dilema created have raised consumers theand This industry. movement is level spreading to of a wider concernaudience, with both whether there is any basis for concern or not. Several of the food additive estrogens are also consumed as part of a known what effects naturalmay be produced when food, consumed in however isolated/ it concen is not
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1161 2:50 GLUTATHIONE RELEASE Tuesday, March 7 AND PHOSPHATIDYLSERINE 1:30 PM to 4:30 PM EXTERNALIZATION DURING APOPTOSIS Room 15A ARE DEPENDENT UPON FUNCTIONAL MULTIDRUG RESISTANCE-ASSOCIATED PLATFORM SESSION: ENDOCRINE DISRUPTORS - PROTEINS, MRPS. R. Marchan, C. L. Hammond, MECHANISMS S. M. Krance and N. Ballatori. Environmental Medicine, University of Rochester School of Chairperson(s): Tammy Stoker, U.S. EPA, Research Triangle Park, NC and Medicine & Dentistry, Rochester, NY. Vickie Wilson, U.S. EPA, Research Triangle Park, NC. #1162 3:10 PERINATAL EXPOSURE TO ∆-9- #1166 1:30 ALTERATION OF THE HYPOTHALAMIC- TETRAHYDROCANNABINOL (THC) PITUITARY GONADAL(HPG) AXIS IN INDUCES APOPTOSIS IN THE FETAL WISTAR MALE RATS FOLLOWING THYMUS. C. A. Lombard, M. Nagarkatti and P. S. A PREPUBERTAL EXPOSURE TO THE Nagarkatti. Pathology and Microbiology, University CHLOROTRIAZINE HERBICIDE SIMAZINE. of South Carolina, School of Medicine, Columbia, T. E. Stoker, A. Buckalew, J. Ferrell, E. Kaydos and SC. R. Cooper. EB, RTD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1163 3:30 NITROSATIVE STRESS INDUCES PHOSPHATIDYLSERINE #1167 1:50 METHOXYCHLOR DELAYS MALE RAT EXTERNALIZATION: SIGNALING ROLE PUBERTAL ONSET THROUGH ANTI- IN PHAGOCYTOSIS. Y. Y. Tyurina2, 1, A. ADIPOGENESIS. X. Wang, J. Nicoll and L. Potapovich2, 1, V. A. Tyurin2, 1, P. Cai2, 1, N. V. You. Biology, CIIT Centers for Health Research, Konduru2, 1, H. Bayir3, 2, B. Fadeel6, D. Stoyanovsky4, Research Triangle Park, NC. A. A. Shvedova5 and V. E. Kagan2, 1. 1Center for Free Radical & Antioxidant Health, University #1168 2:10 ONTOGENY OF CHANGES IN FETAL of Pittsburgh, Pittsburgh, PA, 2EOH, University TESTIS GENE EXPRESSION INDUCED IN of Pittsburgh, Pittsburgh, PA, 3Crit. Care Med., MALE OFFSPRING AFTER MATERNAL 4 TREATMENT WITH DEHP (DIETHYLHEXYL University of Pittsburgh, Pittsburgh, PA, Surgery, 1 1 University of Pittsburgh, Pittsburgh, PA, 5Health PHTHALATE). V. S. Wilson , C. Lambright , J. Furr1, K. Bobseine1, C. Wood1, K. L. Howdeshell2 Effects Laboratory Division, NIOSH, Morgantown, 1 1 WV and 6Division of Molecular Toxicology, and L. E. Gray . Reproductive Toxicology Division, U.S. EPA, ORD, NHEERL, Research Triangle Karolinska Institute of Env. Med., Stockholm, 2 Sweden. Park, NC and EPA./NCSU Cooperative Training Agreement, North Carolina State University #1164 3:50 ACTIVATION OF INTRACELLULAR TRPV1 Raleigh, NC. INDUCES ER STRESS RESPONSE AND CELL DEATH. K. C. Thomas, M. E. Johansen, P. J. Moos, #1169 2:30 EFFECTS OF BDE-47 ON NUCLEAR G. S. Yost and C. A. Reilly. Pharmacology and RECEPTOR REGULATED GENES AND Toxicology, University of Utah, Salt Lake City, UT. IMPLICATIONS FOR THYROID HORMONE DISRUPTION. V. Richardson1, D. Staskal2, M. #1165 4:10 GONIOTHALAMIN INDUCES APOPTOSIS DeVito1 and L. Birnbaum1. 1ORD/NHEERL/ETD/ IN VASCULAR SMOOTH MUSCLE CELLS. PKB, U.S. EPA, Research Triangle Park, NC and S. H. Inayat-Hussain1, C. K. Meng1, N. F. Rajab1, 2Curriculum in Toxicology, UNC at Chapel Hill, K. Yusoff3, M. H. Ishak1, A. M. Ali2 and L. B. Din1. Chapel Hill, NC. 1Environmental Health Programme, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, #1170 2:50 SENSITIVE AND COMPOUND-SPECIFIC Kuala Lumpur, Malaysia, 2Faculty of Science and BIOMARKERS FOR DIETARY EXPOSURE Biotechnology, Universiti Putra Malaysia, Serdang, TO ESTROGENIC COMPOUNDS. M. Heneweer, Malaysia and 3Faculty of Medicine, Universiti J. H. Poortman, M. J. Groot and A. A. Peijnenburg. Teknologi Mara, Shah Alam, Malaysia. Toxicology and Effectmonitoring, RIKILT - Institute TUESDAY of Food Safety, Wageningen, Netherlands. Sponsor: M. VandenBerg. #1171 3:10 EFFECTS OF PHYTOESTROGENS ON CO- CULTURES OF THE MCF7 MAMMARY TUMOR CELL LINE AND PRIMARY HUMAN MAMMARY FIBROBLASTS. J. V. Meeuwen1, A. Piersma2 and M. VandenBerg1. 1Cellular & Molecular Toxicology, IRAS, Utrecht, Netherlands and 2Laboratory for Toxicology, Pathology and Genetics, RIVM, Bilthoven, Netherlands.
up-to-date information at www.toxicology.org 153 , 1, 1
. M. 1
. 2, IN Institute of Institute 2 1 P. and P. and K. NIEHS, , H. Blessing H. , . J. H. J. 2 2 1 M. Metzler and W. A. W. and 2 Q. He Q. and A. Hartwig and 2 M. C. Madden NHEERL/HSD, U.S. U.S. NHEERL/HSD, J. H. Freedman and J. 2 1 , W. Bal W. , Annual Meeting Annual 1 th and 2 and I. Walter and I. , W. Bal W. , 1 1 M. Song , S. Coughlan 2 SOT's 45 SOT's A. J. Ghio , A. J. 1 , C. Thuy , C. , C. Thuy , C. 1 1 , M. Chen 1 1Laboratory of Molecular Toxicology, ETP, ETP, Toxicology, 1Laboratory of Molecular . 1 . V. E. Walker E. Aden, V. J. . S. Bredow, 1 Curriculum in Toxicology, University of North University Toxicology, Curriculum in NC and Durham, University, Duke 1 1 . . Institute of Food Technology and Food Chemistry, Chemistry, and Food Technology Institute of Food Polish Institute of Biochemistry and Biophysics, Alto, CA. Inc., Palo Technologies, 2Agilent DIR, NIEHS, Research Triangle Park, NC and NC and Park, Triangle DIR, NIEHS, Research Research Triangle Park, NC. Park, Triangle Research ALTERS SOLUBLE MANGANESE GENE EXPRESSION PULMONARY of Food Technology and Food Chemistry, Technical Technical Chemistry, and Food Technology of Food and Berlin, Berlin, Germany University Technical University Berlin, Berlin, Germany and Germany Berlin, Berlin, University Technical Sponsor: Poland. Warsaw, Sciences, of Academy IN HUMAN GENE EXPRESSION PROFILE TO EXPOSED SKIN FIBROBLASTS DICHROMATE. POTASSIUM T. Schwerdtle T. A. R. Molinelli 1 Carolina, Chapel Hill, NC and 2 GENOTOXICITY OF SOLUBLE AND AND OF SOLUBLE GENOTOXICITY CADMIUM COMPOUNDS. PARTICULATE Schwerdtle T. 1 2 Metzler CHANGES IN GENE EXPRESSION TO WITH EXPOSURE ASSOCIATED TOXICANTS. ENVIRONMENTAL 2 Divine. Lovelace Respiratory Research Institute, Institute, Research Respiratory Lovelace Divine. NM, NM. Albuquerque, SIGNIFICANCE OF INTERACTIONS METAL TOXIC AND BETWEEN ESSENTIAL TO THE CELLULAR RESPONSE IONS IN HartwigA. DAMAGE. DNA Boyd VIVO Freedman NIOSH, Laboratory Division, . Health Effects Joseph WV. Morgantown, TRANSPORTER-1 METAL DIVALENT VANADIUM AND BY IRON REGULATION PEROXIDE- HYDROGEN MODULATES IN LUNG CELLS. DAMAGE INDUCED DNA EPA, Chapel Hill, NC. Chapel EPA, CHANGES IN TRANSCRIPTOME COPPER: TO HEPG2 CELLS EXPOSED AND INTERACTOME MAPPING PATHWAY IDENTIFICATION. Biochemistry and Biophysics, Polish Academy of Academy Polish Biochemistry and Biophysics, Sponsor: Poland. Warsaw, Sciences,
(Continued) Annual Annual th #1182 3:50 #1179 2:50 #1177 2:10 #1183 4:10 #1178 2:30 #1180 3:10 #1181 3:30 45 154 Meeting & ToxExpo & Meeting
, , 2 , R. 1,4 3 A. J. A. J. . School 2 , R. M.
, L. Li 1 Department and P. S. and P. 3 3 , G. Marsh Immunology and Immunology Cellular and 1 1 1 . . 4 1 A. Oskarsson X. Wang and X. , S. Menard 1 L. You L. E. K. Silbergeld , J. P. Hinson P. , J. 1 Reproductive Toxicology Toxicology Reproductive , D. Scholten , D. 4 1 M. J. McCabe and M. J. 2 , E. Ulleras Department of Biomedical Sciences and , S. E. Ziemba 2 1 1 and M. van den Berg 3 . 2 Environmental Medicine, University of Rochester, of Rochester, Medicine, University Environmental Pharmacology, Wayne State University, Detroit, MI, State University, Wayne Pharmacology, MI and Detroit, State University, Wayne Medicine, Department of Environmental Chemistry, Chemistry, Department of Environmental Utrecht, Antonius Hospital, Nieuwegein, St. Veterinary Public Health, Swedish University of of University Health, Swedish Public Veterinary Agricultural Sciences, Uppsala, Sweden, K. A. Plant K. Microbiology, Wayne State University, Detroit, MI, State University, Wayne Microbiology, Molecular Toxicology, IRAS, Utrecht, Netherlands, Toxicology, Molecular Goldfarb Biology, CIIT Centers for Health Research, CIIT Centers Biology, NC. Park, Triangle Research FOR TRANSCRIPT PROFILING THE H295R GENES IN STEROIDOGENIC - ADRENAL AND HUMAN CELL LINE TOOL A SCREENING DEVELOPMENT OF ADRENOTOXICANTS. FOR Rochester, NY. Rochester, 2 3 4 . Environmental Health Nyland. Environmental F. Gardner and J. School of Sciences, Johns Hopkins University Health, Baltimore, MD. Public THE MECHANISM OF INORGANIC AND T OF ERK IN DISRUPTION MERCURY UPSTREAM INVOLVES B LYMPHOCYTES AND BCR TCR THE ELEMENTS IN TRANSDUCTION PATHWAYS. SIGNAL CHARACTERIZING HUMAN CHARACTERIZING MERCURY-INDUCED TO SUSCEPTIBILITY IMMUNOTOXICITY. P. C. Jong P. 2 and Stockholm, Sweden Stockholm University, 3 Netherlands. United Kingdom and Canton R. Fernandez INTERACTIONS OF INSULIN-LIKE OF INTERACTIONS RECEPTOR FACTOR-1 GROWTH IN ARE INVOLVED AROMATASE AND AND METHOXYCHLOR GENISTEIN- INDUCED EPITHELIAL IN RAT HYPERPROLIFERATION GLAND. MAMMARY of Endocrinology, St Bartolomews and The and St Bartolomews of Endocrinology, London School of Medicine and Dentistry, Royal London, College, Westfield Queen Mary and Astra Assessment, & Distribution Imaging, Safety Sodertalje, Sweden. Zeneca R&D, METABOLISM STEROIDOGENIC VITRO IN CAN BE INHIBITED BY PBDE DERIVATIVES BDES) AND METHOXYLATED (HYDROXY MICROSOMES. IN HUMAN PLACENTAL R. Mattingly Rosenspire of Biomedical & Molecular Sciences, University of of Biomedical & Molecular Sciences, University United Kingdom, Guildford, Surrey,
45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1173 3:50 #1176 1:50 : Ellen Silbergeld, Johns Hopkins University, Baltimore, Baltimore, Hopkins University, Johns Chairperson(s): Ellen Silbergeld, MI. Detroit, State University, Wayne Allen Rosenspire, MD and #1175 1:30 1:30 PM to 4:30 PM Room 7A I TOXICOLOGY METALS SESSION: PLATFORM Tuesday, March 7 March Tuesday, #1172 3:30
#1174 4:10 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 #1190 3:30 OXIDATION OF INDIGO CARMINE BY PEROXYNITRITE ( CO ): IMPLICATIONS 1:30 PM to 4:30 PM ± 2 Room 7B FOR THE HYPOTHESIS ON OZONE PRODUCTION BY NEUTROPHILS. V. Rangan, PLATFORM SESSION: OXIDATIVE INJURY T. E. Perumal, K. Sathishkumar and R. M. Uppu. Environmental Toxicology and Health Research Chairperson(s): Mary Beth Genter, University of Cincinnati, Center, Southern University and A&M College, Environmental Health, Cincinnati, OH and Adrian Nicolescu, Queens Baton Rouge, LA. University, Kingston, ON, Canada. #1191 3:50 COMBINATIVE TOXICITY OF SODIUM #1184 1:30 ALTERATION OF HEME-OXYGENASE PERCHLORATE AND SODIUM ARSENATE EXPRESSION IN A549 CELLS BY URBAN IN ZEBRAFISH (I)DANIO RERIO(I/): DUST PARTICULATE MIXTURE 1649A. OXIDATIVE STRESS AND GENOTOXICITY A. De Vizcaya-Ruiz, M. Uribe-Ramirez and M. PERSPECTIVE. F. Liu1, J. Wang1, M. Hooper1 and E. Cebrián. Toxicology Section, CINVESTAV- C. Theodorakis2. 1Department of Environmental Zacatenco, Mexico D.F., Mexico. Toxicology, The Institute of Environmental and Human Health, Texas Tech Universiyt, Lubbock, #1185 1:50 THIOREDOXIN-MEDIATED AIRWAY TX and 2Department of Biology, Southern Illinois EPITHELIAL CELL PROTECTION FROM University at Edwardsville, Edwardsville, IL. SMOKE THROUGH THE SUPPRESSION OF JNK PATHWAY. Y. Lee, C. Chuang, P. Lee, J. #1192 4:10 CROSS-LINK BLOCKING AND THE Lee, R. Harper and R. Wu. Center for Comparative MECHANISM OF ACTION OF HYDRAZINO Respiratory Biology and Medicine, University of DRUGS AGAINST ACROLEIN TOXICITY. California at Davis, Davis, CA. Sponsor: J. Last. P. C. Burcham. Pharmacology Unit, University of Western Australia, Perth, WA, Australia. Sponsor: F. #1186 2:10 ANTIOXIDANTS RESCUE HYPEROXIA- Grzemski. INDUCED SUPPRESSION OF MACROPHAGE PHAGOCYTOSIS OF PSEUDOMONAS AERUGINOSA. L. Mantell1, 2, D. M. Morrow2, 1 Tuesday, March 7 and T. Entezari Zaher1, 2. 1Pharmaceutical Sciences, 1:30 PM to 4:30 PM St Johns University College of Pharmacy, Queens, Room 5A NY and 2Cardiopulmonary Research, Institute for Medical Research at North Shore-LIJ Health PLATFORM SESSION: PARTICULATE MATTER: EFFECTS AND System, Manhasset, NY. MECHANISMS #1187 2:30 PRO-OXIDANT IMPACT OF DIESEL ENGINE Chairperson(s): JeanClare Seagrave, Lovelace Respiratory Research EMISSIONS ACCORDING TO FUEL AND Institute, Albuquerque, NM and Ian Gilmour, U.S. EPA, Research Triangle AFTER-TREATMENT STRATEGIES: Park, NC. IN VITRO AND IN VIVO BIOLOGICAL #1193 1:30 BIOLOGICAL RESPONSES TO EVIDENCES FOR NEW POTENTIAL 1 1 PARTICULATE MATTER IN COMPROMISED HEALTH CONCERNS. J. MORIN , D. Preterre , RATS: THE ROLE OF TRANSITION M. Isabelle1, A. Bion1, 2, M. Fall1 and F. Dionnet2. 1 2 METAL AND POLYCYCLIC AROMATIC U644, INSERM, ROUEN, France and CERTAM, HYDROCARBON CONTENTS. M. Gerlofs- Saint Etienne du Rouvray, France. Sponsor: R. Nijland1, J. Boere1, D. Leseman1, R. Salonen2, M. Forster. Sillanpaa4, R. Duffin3, 5, R. Schins3, P. Borm3 and F. 1 1 #1188 2:50 PARAQUAT STIMULATES CYANIDE- Cassee . National Institute for Public Health and 2 INSENSITIVE RESPIRATION AND NADPH the Environment, Bilthoven, Netherlands, National 3 OXIDASE ACTIVITY IN MURINE LUNG Public Health Institute, Kuopio, Finland, Insitut EPITHELIAL CELLS. J. P. Gray1, V. M. Mishin1, fur Umweltmedizinische Forschung, Dusseldorf, 2 3 3 Germany, 4Finnish Meteorological Institute, P. J. Smith , M. Thiruchelvam , D. A. Cory-Slechta , TUESDAY 5 D. E. Heck1 and J. D. Laskin3. 1Pharmacology and Helsinki, Finland and University of Edinburgh, Toxicology, Rutgers University, Piscataway, NJ, Scotland, United Kingdom. 2Biocurrents Research Center, Marine Biological 3 #1194 1:50 COMPARISON OF CARDIOPULMONARY Laboratory, Woods Hole, MA and Environmental RESPONSES OF WISTAR KYOTO (WKY) & Occupational Medicine, UMDNJ-RWJMS, AND STROKE PRONE SPONTANEOUSLY Piscataway, NJ. HYPERTENSIVE RATS (SHRSP) TO #1189 3:10 OXIDATION OF NAD(P)H BY PARTICULATE MATTER (PM) EXPOSURE. 1 2 HYPOCHLOROUS ACID AND J. G. Wallenborn , M. C. Schladweiler , A. D. 2 3 3 2 PEROXYNITRITE (± CO ): A COMPARATIVE Ledbetter , A. Nyska , J. Johnson , R. F. Thomas , 2 2 2 STUDY. R. M. Uppu, V. Rangan, C. R. Sparrow and R. Jaskot , J. H. Richards and Universtiy of. 2 1 T. E. Perumal. Environmental Toxicology and Health P. Kodavanti . Environmental Sciences and Research Center, Southern University and A&M Engineering, University of North Carolina at Chapel 2 College, Baton Rouge, LA. Hill, Chapel Hill, NC, NHEERL/ETD, U.S. EPA, Research Triangle Park, NC and 3NIEHS, Research Triangle Park, NC. up-to-date information at www.toxicology.org 155
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2 U.S. EPA, EPA, U.S. 2 , C. Gennings 2 . Curriculum in Curriculum in 1 1 M. F. Hughes , M. F. . . 1 , B. Roop , B. Annual Meeting Annual 2 3 1 th National Center for 2 Department of Biostatistics, 3 U.S. EPA, Research Triangle Triangle Research EPA, U.S. 1 . S. J. Godin S. J. 1 M. K. Ross SOT's 45 SOT's CEHS, Mississippi State University, CEHS, Mississippi State University, 3 and 2 H. A. Barton and H. National Institute of Standards and 1 National Research Council, Research 1 NHEERL, U.S. EPA, Research Triangle Triangle Research EPA, NHEERL, U.S. 2 P. J. J. McGarrigle,P. P. Knaak, B. B. , J. . Pharmacology and R. Olson. Pharmacology and J. . 2 2 Park, NC, Park, EXPOSURE TO FOUR DIFFERENT TO EXPOSURE Jakupciak J. CONAZOLES. SPECIES DIFFERENCES IN THE IN SPECIES DIFFERENCES OF PYRETHROID METABOLISM AND HUMAN LIVER PESTICIDES IN RAT MICROSOMES. GENE IN mRNA ALTERATIONS WITH ASSOCIATED EXPRESSION CELL METABOLISM, CHOLESTEROL STRESS INDUCED AND OXIDATIVE CYCLE, CONAZOLES TRIAZOLE CONTAINING BY Thai, D. Roop, S. B. LIVER. S. Nesnow, IN RAT U.S. , C. Jones, G. Nelson and S. Hester. Wolf C. Durham, NC. EPA, P450 UTILIZING HUMAN CYTOCHROME ACTIVITY AND SPECIFIC CONTENT AND BETTER MODEL PARATHION TO IN CHLORPYRIFOS METABOLISM ADULTS. AND CHILDREN, INFANTS, J. P. Stanko P. J. and K. M. Crofton Hill, Chapel Hill, NC and S. Hester Durham, NC. Sponsor: M. DeVito Hill, NC, Mississippi State, MS. RISK OF PYRETHROIDS: CUMULATIVE ACUTE THE ADDITIVTY OF TESTING EFFECTS OF ELEVEN MOTOR Wolansky M. J. PYRETHROIDS. VA. Richmond, VCU, P450 INHIBITION OF CYTOCHROME PESTICIDES THE CONAZOLE 2B1 BY TRIADIMEFON. AND MYCLOBUTANIL Toxicology, SUNY at Buffalo, Buffalo, NY. Buffalo, SUNY at Buffalo, Toxicology, Toxicology, University of North Carolina at Chapel University Toxicology, Kostyniak Toxicology, University of North Carolina, Chapel University Toxicology, Foxenberg M. J. DeVito M. J. Computational Toxicology Environmental Protection Environmental Toxicology Computational NC. Park, Triangle Research Agency, OF AND EXAMINATION ASSESSMENT SEQUENCE DNA MITOCHONDRIAL HUMAN CHANGES IN PRIMARY VITRO IN FOLLOWING HEPATOCYTES Technologies, Gaithersburg, MD and Gaithersburg, Technologies, Park, NC and Park, NC and Park, Triangle
1:30 PM–4:30 PM 1:30 PM–3:00 PM (Continued) Annual Annual th #1202 #1206 #1207 1:30 PM to 4:30 PM Exhibit Hall PESTICIDES POSTER SESSION: Med., Vet. of College MD Regional VA Chairperson(s): Marion Ehrich, CA. Sacramento, Gammon, CA EPA, and Derek VA Blacksburg, Displayed: Attended: #1203 #1204 Tuesday, March 7 March Tuesday, #1205 45 156
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L. Chen MatTek Corp., Ashland, MA Ashland, Corp., MatTek , D. Leseman , D. 2 1 , Q. Li , Q. , K. Gowdy , X. Jin 1 1 2 and 2 J. Seagrave J. Nelson Institute of Environmental Nelson Institute of Environmental 1 University of Edinburgh, Edinburgh, Edinburgh, of Edinburgh, University 5 . , P. Hayden , P. Lovelace Respiratory Research Institute, Lovelace Curriculum of Toxicology, University University Toxicology, Curriculum of 1 1 1 1 and S. Rajagopalan K. Donaldson . . 1 , N. Janssen , N. 1 1 , , Q. Sun , Q. and I. Jaspers 1 2 1 3 National Institute for Public Health and National Institute for Public , M. Zhong 1 1 . Universtiy of. New Mexico, Albuquerque, NM. Albuquerque, Mexico, of. New Universtiy U.S. EPA, Research Triangle Park, NC. Park, Triangle Research EPA, U.S. Mount Sinai School of Medicine, New York. Mount Sinai School of Medicine, New 1 3 3 2 L. Chen NHEERL, Environmental Protection Agency, Agency, Protection NHEERL, Environmental University Hospital Umea, Umea, Sweden, Hospital Umea, Umea, Sweden, University Assessment Sciences, Utrecht, Institute for Risk of North Carolina, Chapel Hill, NC, Medicine, Tuxedo Park, NY and Park, Tuxedo Medicine, Mauderly J. M. Ciencewicki J. the Environment, Bilthoven, Netherlands, Bilthoven, the Environment, Mudway Medicine, New York University, Tuxedo Park, NY Park, Tuxedo University, York Medicine, New NY and Tuxedo, SOM, and 3 NC. Park, Triangle Research HUMAN PRIMARY DIFFERENTIATED TO LUNG EPITHELIAL CELLS EXPOSED AIR-LIQUID AN AT (DE) DIESEL EXHAUST INTERFACE. AND EPITHELIAL CELLS. R. Boyles Gilmour Chapel Hill, Chapel Hill, NC, and 3 4 Netherlands, United Kingdom and M. Gerlofs-Nijland Bloemen Bree of North Carolina at Chapel Hill, Chapel Hill, NC X. Jin Lippmann NY. Institute, Mt Sinai SOM, NY, AMBIENT OF POTENCY TOXIC VIVO IN MATTER AND FINE PARTICULATE COARSE EUROPE. ACROSS SAMPLED C. Quan S. Rajagopalan and A NEW APPROACH IN HEART RATE RATE HEART IN APPROACH A NEW ASSESS TO ANALYSIS (HRV) VARIABILITY IN MICE FAILURE THE RISK OF HEART PARTICULATE AIRBORNE TO EXPOSED LI (PM). Q. MATTER and Rome, Italy. AMBIENT PM ON CYTOKINE EFFECTS OF IN MOUSE MACROPHAGES PRODUCTION of North at Carolina and Engineering, University Albuquerque, NM, Albuquerque, I. Jaspers S. Dunaway EFFECTS OF DIESEL EXHAUST ON TLR3 ON EFFECTS OF DIESEL EXHAUST IN MICE. AND SIGNALING EXPRESSION AMBIENT PARTICULATE MATTER MATTER AMBIENT PARTICULATE ACCELERATES EXPOSURE VASCULAR AND ATHEROSCLEROSIS INFLAMMATION. Academia Sinica, Taipei, Taiwan. Taipei, Academia Sinica, II POTENTIATE ANGIOTENSIN AMBIENT PARTICULATE CONCENTRATED (CAPS) INDUCED HYPERTENSION MATTER IN RATS. DYSFUNCTION VASCULAR AND North Carolina State University, Raleigh, NC and North Carolina State University, College London, London, United Kingdom, College 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1201 4:10 #1198 3:10 #1195 2:10
#1199 3:30 Program Description Description Program #1200 3:50 #1197 2:50 #1196 2:30
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1208 IN VITRO METABOLISM OF TRIADIMEFON #1216 METHOXYCHLOR-INDUCED INDUCIBLE BY RAT LIVER MICROSOMES. Y. M. sey. U.S. NITRIC OXIDE SYNTHASE AND EPA, Research Triangle Park, NC. PROINFLAMMATORY CYTOKINES EXPRESSION IN MACROPHAGES : MAPKS #1209 FIPRONIL INDUCES CYP3A4 CYP2B6 AND NF-κB AS POTENTIAL MOLECULAR AND CYP1A1 GENE EXPRESSION AND TARGETS. J. Kim1, 2, K. Oh1, 2, E. Han1, 2, H. Kim2, APOPTOSIS IN HUMAN HEPATOCYTES. P. C. Y. Hwang1, 2, D. Kim3 and H. Jeong1, 2. 1Pharmacy, 1 2 1 1 Das , N. Cherrington , Y. Cao , E. Hodgson and R. Chosun University, Kwangju, South Korea, 1 1 L. Rose . Environmental & Molecular Toxicology, 2Research Center for Proteineous Materials, Chosun North Carolina State University, Raleigh, North University, Kwangju, South Korea and 3Pathology, 2 Carolina, NC and College of Pharmacy, University College of Oriental Medicine, Daejeon University, of Arizona, Tucson, AZ. Daejeon, South Korea. #1210 THE USE OF ZEBRAFISH TO ELUCIDATE #1217 IDENTIFICATION OF A NOVEL THE MECHANISM OF DITHIOCARBAMATE HEMOGLOBIN ADDUCT IN SPRAGUE- DEVELOPMENTAL TOXICITY. F. Tilton, DAWLEY RATS EXPOSED TO ATRAZINE. J. K. La Du, N. Alzarban and R. L. Tanguay. G. Dooley1, J. Prenni2, B. Cranmer1, P. Prentiss1, Environmental and Molecular Toxicology, MFBSC, M. Andersen3 and J. Tessari1. 1Environmental and EHSC, Oregon State University, Corvallis, OR. Radiological Health Sciences, Colorado State 2 #1211 CHLORPYRIFOS AND ITS METABOLITES University, Fort Collins, CO., Macromolecular INDUCE APOPTOSIS IN PLACENTAL Resources, Colorado State University, Fort Collins, 3 CHORIOCARCINOMA CELLS. M. D. CO and Chemical Industrial Institute of Toxicology, Saulsbury, S. O. Heyliger, D. Round, Q. Chen, K. Research Triangle Park, NC. Wang, J. Morse and D. J. Johnson. Pharmaceutical #1218 UP-REGULATION OF CYCLOOXYGENASE- Sciences, Hampton University, Hampton, VA. 2 GENE EXPRESSION BY ALPHA- AND #1212 DEVELOPMENTAL EXPOSURE TO BETA-ENDOSULFAN IN MACROPHAGES. 1, 2 1 1, 2 1 ENVIRONMENTALLY RELEVANT K. N. Oh , J. Y. Kim and H. Jeong . Pharmacy, CONCENTRATIONS OF DIELDRIN IN BABL/ Chosun University, Kwangju, South Korea and 2 C MICE DOES NOT AFFECT MAMMARY Research Center for Proteineous Materials, Chosun GLAND DEVELOPMENT. W. G. Foster, P. University, Kwangju, South Korea. Mirshokraei, S. Bulk and A. C. Holloway. OBS/ #1219 USE OF EXPOSURE RELATED DOSE GYN, McMaster University, Hamilton, ON, Canada. ESTIMATING MODEL (ERDEM) TO #1213 BEHAVIOR OF FENTHION AFTER CONSTRUCT A PBPK/PD MODEL FOR CHLORINATION TREATMENT AND EFFECT CARBOFURAN WITH THE REPORTED OF ITS PRODUCTS ON CHOLINESTERASE EXPERIMENTAL DATA IN THE RAT. X. 1 2 2 3 ACTIVITY. T. Nishimura1, M. Tahara1, R. Kubota1, Zhang , M. S. Okino , F. W. Power , J. B. Knaak , A. 1 1 1 K. Shimizu1, M. Ema2 and H. Tokunaga1. 1Division M. Tsang , L. S. Harrison , C. B. Thompson and 2 1 of Environmental Chemistry, National Institute of C. C. Dary . Anteon Corporation, Las Vegas, NV, 2 3 Health Sciences, Tokyo, Japan and 2Division of Risk NERL, U.S. EPA, Las Vegas, NV and Department Assessment, Biological Safety Research Center, of Pharmacology and Toxicology, SUNYAB, National Institute of Health Sciences, Tokyo, Japan. Buffalo, NY. #1214 REACTIVE OXYGEN SPECIES #1220 THE ROLE OF 4-METHYLPYRAZOLE AS INVOLVEMENT IN THE PESTICIDES- THE ANTIDOTE FOR 2-CHLOROETHANOL INDUCED CYTOTOXICITY IN NEURONAL INTOXICATION. D. Hung, Y. Chen and C. Hsu. CELLS (SH-SY5Y), IN VITRO. Z. Jia1 and H. Emergency Toxicology, Taichung Veterans General Misra1, 2. 1Department of Biomedical Sciences Hospital, Taichung, Taiwan. Sponsor: S. Lin-Shiau. and Pathobiology, Virginia Tech, Blacksburg, VA TUESDAY and 2Edward via Virginia College of Osteopathic Medicine, Blacksburg, VA. #1215 THE USE OF THE INHIBITORY RATE
CONSTANT KI TO CHARACTERIZE INHIBITION OF ACETYLCHOLINESTERASE BY ORGANOPHOSPHATES. C. Rosenfeld1 and L. G. Sultatos2. 1Schering-Plough Research Institute, Lafayette, NJ and 2Pharmacology & Physiology, UMD New Jersey Medical School, Newark, NJ.
up-to-date information at www.toxicology.org 157 1, . . 1, , K. , C. 2 1, 2 1 , R. 2 , S. I. Rusyn -INDUCED 1 1, 2 , O. Kosyk , O. and Environmental Environmental Linus Pauling Linus Pauling 3 1, 2 1 2 . , J. Kang , J. 2 2 Annual Meeting Annual Department of , J. D. Hendricks D. , J. 2 College of Pharmacy, of Pharmacy, College th 1 A. N. Bachman and A. N. Center for Hepatitis , T. Sukata T. , 3 2 . 1, 2 D. E. Williams E. and D. 2 1, 2 C. L. Powell S. Kim , M. Wei , M. 2 S. Fukushima SOT's 45 SOT's , A. Kinoshita , , S. A. Weinman A. , S. 2 3 S. C. Tilton S. C. and 1 J. I. Goodman J. and G. S. Bailey , G. 3 1, 2 , J. Lee , J. Department Environmental Sciences & Department Environmental 1 2 Curriculum in Toxicology, University of University Toxicology, Curriculum in ]QUINOXALINE -INDUCED RAT -INDUCED RAT F]QUINOXALINE 1 College of Pharmacy, Seoul National University, Seoul National University, of Pharmacy, College Environmental and Molecular Toxicology, Oregon Oregon Toxicology, and Molecular Environmental Department State University, of Statistics, Oregon Wanibuchi , H. . North Chapel Hill, Carolina at Chapel Hill, Pharmacology and Toxicology, Michigan State Michigan Toxicology, and Pharmacology East Lansing, MI. University, B AFLATOXIN MECHANISM OF Seoul, South Korea. State University, Corvallis, OR, Corvallis, State University, OR. Corvallis, DOSE-DEPENDENCE OF PROMOTION 8-DIMETHYLIMIDAZO[4, OF 2-AMINO-3, Institute, Oregon State University, Corvallis, OR and Corvallis, State University, Institute, Oregon Kang 2 1 3 5- 2 Puatanachokchai Co., Ltd., Osaka, Japan and Osaka, Japan. OF GENE EXPRESSION COMPARISON THREE MICE FED FROM PROFILES DIFFERENT TOXICOLOGICALLY Ward, W. CONAZOLES. TRIAZOLE-BASED Allen, C. Jones, D. Roop, J. Thai, B. S. Hester, S. Environmental Delker. and D. , S. Nesnow Wolf Research EPA, U.S. Division, Carcinogenesis NC. Park, Triangle S- INDUCTION OF GLUTATHIONE TYPE I RECEPTOR TRANSFERASE IN IGF CELLS. HEPATOMA OVEREXPRESSED EFFECT OF ALCOHOL ON OXIDATIVE ALCOHOL ON OXIDATIVE EFFECT OF IN MOUSE DAMAGE AND DNA STRESS VIRAL C HEPATITIS LIVER EXPRESSING CORE PROTEIN. 2 NC, Hill, Chapel Hill, NC and (B6) MICE. Pathology, Osaka City University Medical School, Medical Osaka City University Pathology, and South Korea Gwangju, Chosun University, HEPATOCARCINOGENESIS BY ETHANOL; BY ETHANOL; HEPATOCARCINOGENESIS M. Kushida THRESHOLD. A EVIDENCE FOR Uwagawa Sumitomo Chemical Health Science Laboratory, Engineering, University of North Carolina at Chapel Engineering, University B. Pereira B. L. A. Showalter L. Research, University of Texas Medical Branch, Texas of Research, University TX. Galveston, TIME INDUCES UNIQUE PHENOBARBITAL AND OF GC-RICH DEPENDENT PATTERNS METHYLATION ALTERED GENE-SPECIFIC B6C3F1 TUMOR-PRONE THE LIVER OF IN THE BY TUMOR PROMOTION HEPATIC ’- 3, 3, PHYTOCHEMICAL DIETARY TOXICOGENOMIC A DIINDOLYLMETHANE: APPROACH.
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, E. Y. Lee Y. , E. 3 Biochem. Graduate Center 1 1 Pharmacology Pharmacology . 4 . 4 , K. R. Isaacs B ON 1 2 κ , M. Negishi 2 Drug Safety Evaluation, Drug Safety Evaluation, 1 . , H. Lehmler 1 1 CITP, Harrogate, United CITP, 3 , C. Desdouets Microbiology/Immunology and Microbiology/Immunology Department of Occupational and 1 2 3 Safety Assessment, AstraZeneca, Assessment, Safety Reproductive and Developmental and Developmental Reproductive 4 , Y. Yamamoto Y. , H. P. Glauert and H. P. 2 Pathology and Laboratory Medicine, Pathology J. I. Goodman and J. 1 4 4 3 Experimental Pathology, NIEHS, NIH, Experimental Pathology, , B. T. Spear T. , B. 3 1 and E. Boitier 4 C. Michel Toxicology, NIEHS, NIH, Research Triangle Triangle NIEHS, NIH, Research Toxicology, NC, Park, & Mol. Biol., Mich. State Universtiy of., East & Mol. Biol., Mich. State Universtiy EFFECT OF THE DELETION OF EFFECT OF OF NF- THE P50 SUBUNIT W. Robertson W. for Nutritional Sciences, University of Kentucky, Kentucky, of for Nutritional Sciences, University KY, Lexington, Lansing, MI. Lansing, MI, Roberts Kingdom and Cheshire, United Kingdom. ORPHAN NUCLEAR RECEPTOR ACTIVE/ANDROSTANE CONSTITUTIVE (CAR)-MEDIATED RECEPTOR METHYLATION IN DNA ALTERATIONS (PB) DURING PHENOBARBITAL TUMORIGENESIS. OF LIVER PROMOTION , G. Orphanides and J. G. Moggs. Syngenta G. Moggs. Kimber, G. Orphanides and J. CTL, Macclesfield, Cheshire, United Kingdom. IMMUNOHISTOCHEMICAL PRE- OF CHARACTERIZATION NEOPLASTIC LESIONS OBSERVED A LONG-TERM CLOFIBRIC IN NON-GENOTOXIC ACID-INDUCED THE IN STUDY HEPATOCARCINOGENESIS RAT. HEPATOCARCINOGENESIS IN MICE IN MICE HEPATOCARCINOGENESIS AND RECEIVING DIETHYLNITROSAMINE C. J. BIPHENYLS. POLYCHLORINATED Tharappel Molecular Genetics, University of Kentucky, of Kentucky, Molecular Genetics, University KY, Lexington, Iowa of Iowa, Health, University Environmental IA and City, sanofi aventis, Vitry-sur-Seine, France, France, Vitry-sur-Seine, sanofi aventis, France, U370, Paris, University of Kentucky, Lexington, KY. Lexington, of Kentucky, University ASSOCIATED MOLECULAR MECHANISMS AND ABERRANT LIVER GROWTH WITH TREATED CARCINOGENESIS IN F344 RATS CARCINOGENS. WITH NONGENOTOXIC M. Phillips J. Currie, J. Dow, R. Lee, L. Cottrell, C. Sadler, F. Lim, F. R. Lee, L. Cottrell, C. Sadler, Dow, Currie, J. Ashby, J. Waterfield, C. Wright, J. A. Hargreaves, Research Triangle Park, NC and Park, Triangle Research and Toxicology, Mich. State Universtiy of., East Mich. State Universtiy Toxicology, and R. Maronpot
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#1221 #1224 #1223 Attended: : Ammie Bachman, Michigan State University, East East University, State Michigan Bachman, Ammie Chairperson(s): MI. Lansing, Displayed: Exhibit Hall HEPATOCARCINOGENESIS POSTER SESSION: Tuesday, March 7 March Tuesday, 1:30 PM to 4:30 PM Program Description Description Program #1222
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1231 COMPARATIVE LIVER EFFECTS OF #1237 ATRAZINE DISPOSITION IN PREGNANT CYPROCONAZOLE AND PHENOBARBITAL AND LACTATING LONG-EVANS RATS. J. L. IN THREE STRAINS OF MICE. R. C. Peffer1, T. Rayner1, 3, E. P. Hines3, R. Barbee3, J. V. Nguyen2, Pastoor1, G. Millburn2, J. Wright2, H. Eyton-Jones2, P. Panuwet2, D. B. Barr2, R. D. Whitehead2 and S. J. Harris2, J. Kilgour2, F. Waechter3 and J. Moggs2. E. Fenton3. 1DESE, UNC-Chapel Hill, Chapel Hill, 1Global Human Safety, Syngenta Crop Protection, NC, 2Division Laboratory Sciences, NCEH, CDC, Inc., Greensboro, NC, 2Central Toxicology Atlanta, GA and 3RTD, NHEERL, ORD, U.S. EPA, Laboratory, Syngenta Ltd., Macclesfield, United Research Triangle Park, NC. Kingdom and 3Syngenta AG, Basel, Switzerland. #1238 GENE EXPRESSION PROFILING SUGGESTS A CONSERVED INITIAL MECHANISM Tuesday, March 7 FOR FETAL AND PUBERTAL PHTHALATE 1:30 PM to 4:30 PM TESTICULAR INJURY. K. Johnson, D. Wallace Exhibit Hall and S. Lahousse. CIIT Centers for Health Research, Research Triangle Park, NC. Sponsor: K. Gaido. POSTER SESSION: MULTIGENERATION REPRODUCTIVE TOXICITY EVALUATIONS #1239 AN INHALATION F1 GENERATION REPRODUCTIVE TOXICITY STUDY OF OCT Chairperson(s): Rochelle Tyl, RTI International, Research Triangle Park, AMETHYLCYCLOTETRASILOXANE (D4) IN NC and Barbara Neal, The Weinberg Group, Washington, DC. FEMALE RATS. W. H. SIDDIQUI1, D. G. Stump2, J. F. Holson2, D. T. Kirkpatrick2 and K. P. Plotzke1. Displayed: 1:30 PM–4:30 PM 1Health and Environmental Sciences, Dow Corning Corporation, Midland, MI and 2Developmental Attended: 1:30 PM–3:00 PM and Reproductive Toxicology, WIL Research #1232 THE EFFECTS OF INHALED VAPORS OF Laboratories, LLC, Ashland, OH. ACRYLONITRILE ON RAT REPRODUCTION OVER TWO SUCCESSIVE GENERATIONS. #1240 28-DAY GAVAGE AND REPRODUCTIVE/ M. D. Nemec1, D. T. Kirkpatrick1, J. Sherman1, J. DEVELOPMENTAL SCREENING TOXICITY Van Miller2 and D. E. Strother3. 1WIL Research STUDIES OF DODECAMETHYLCYCLOHE Laboratories, LLC, Ashland, OH, 2Toxicology/ XASILOXANE (D6) IN SPRAGUE-DAWLEY 1 2 2 Regulatory Services, Inc., Charlottesville, VA and RATS. B. Carlton , W. H. SIDDIQUI , L. Meeker , 2 2 2 3Innovene, Chicago, IL. J. Crissman , J. Knochel , S. Crofoot and K. Plotzke2. 1Toxicology, Rhodia Inc., Raleigh, NC and #1233 THE HERBICIDE LINURON REDUCES 2Health and Environmental Sciences, Dow Corning FETAL TESTOSTERONE PRODUCTION Corporation, Midland, MI. DURING BOTH IN UTERO AND IN VITRO EXPOSURES. C. Lambright1, J. Furr1, K. #1241 THE REPRODUCTIVE TOXICITY OF Howdeshell2, L. Gray1 and V. Wilson1. 1ORD/RTD, SODIUM TUNGSTATE IN THE SPRAGUE- U.S. EPA, Research Triangle Park, NC and 2U.S. DAWLEY RAT. E. W. Johnson, H. J. Boeckman, EPA, NCSU Cooperative Training Agreement, D. P. Arfsten, B. L. Steele, M. J. Thompson, K. W. Raleigh, NC. Reilly, S. L. Prues, M. R. Varney, J. R. Cunningham, A. M. Lear, M. Giesige, D. Thompson, T. L. #1234 A TWO-GENERATION Naylor and E. R. Wilfong. Naval Health Research REPRODUCTION STUDY WITH Center Detachment Environmental Health Effects PERFLUOROBUTANESULFONATE IN RATS. Laboratory, Wright-Patterson AFB, OH. J. Butenhoff and P. Lieder. 3M Company, St. Paul, MN. #1242 TWO-GENERATION STUDY OF DIETARY 17β-ESTRADIOL (E2) IN CD-1® SWISS MICE. #1235 ACRYLONITRILE: EVALUATION OF R. W. Tyl1, C. B. Myers1, M. C. Marr1, C. S. Sloan1, REPRODUCTIVE AND DEVELOPMENTAL N. P. Castillo1, M. M. Veselica1, J. C. Seely2, S. S. 1 2 3 3 4 5 TOXICITY. B. Neal , D. E. Strother , J. J. Collins Dimond , J. P. Van Miller , G. D. Stropp and J. M. TUESDAY and J. C. Lamb1. 1The Weinberg Group, Washington, Waechter6. 1RTI International, Research Triangle DC, 2Innovene, Chicago, IL and 3The Dow Chemical Park, NC, 2EPL, Inc., Research Triangle Park, NC, Company, Midland, MI. 3GE Advanced Materials, Plastics, Pittsfield, MA, 4Toxicology/Regulatory Services, Charlottesville, #1236 A TWO-GENERATION REPRODUCTIVE VA, 5Bayer HealthCare AG, Wuppertal, Germany TOXICITY STUDY OF DAG and 6Dow Chemical Co., Midland, MI. (DIACYLGLYCEROL) ADMINISTERED ORALLY BY GAVAGE IN RATS. B. J. Varsho1, J. #1243 SEX RATIO OF THE OFFSPRING OF F. Knapp1, M. D. Nemec1, D. G. Stump1, O. Morita2, SPRAGUE-DAWLEY RATS EXPOSED TO Y. Tamaki2 and H. Suzuki2. 1DART, WIL Research TCDD IN UTERO AND LACTATIONALLY IN Laboratories, LLC, Ashland, OH and 2Safety and A THREE-GENERATION STUDY. J. Rowlands1, Environmental Research, Kao Corporation, Haga R. A. Budinsky1, L. L. Aylward2 and E. W. Carney1. Tochigi, Japan. 1The Dow Chemical Company, Midland, MI and 2Exponent, Inc., Alexandria, VA.
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, F. , F. , R. 5 , 1 1 2 . 1 and , 2 , Z. Li 1 2 , A. , 1 , L. Ferriby , B. Pesch , B. 1 3 , Z. Li , L. Cizmas 1 1 , R. Preuss 1 , G. Zhou 1 , J. Angerer , J. 1 ChemRisk, San and M. R. Moore 5 D. Paustenbach , D. Bau-BG, Muenchen/ 1 4 . 3 Annual Meeting Annual Texas A&M University, A&M University, Texas , K. Schott 1 1 , L. He th Center for Toxicology Toxicology Center for . 1 3 , R. Autenrieth , R. and K. C. Donnelly 1 1 3 Institute of Reproductive Institute of Reproductive BGIA, Sankt Augustin, BGIA, Sankt 2 4 , T. J. McDonald J. T. , , T. Mensing T. , Queensland Health Scientific IPASUM, University of University IPASUM, , K. Unice 1 4 2 2 M. Hughes 3 SOT's 45 SOT's Sumgayit Centre for Environmental for Environmental Centre Sumgayit , R. Maddelena 3 1 , M. Raulf-Heimsoth 1 BGFA, Ruhr University of Bochum, of Bochum, Ruhr University BGFA, ChemRisk, Inc., Houston, TX, ChemRisk, Inc., Houston, , G. Denoux 1 1 1 , C. Naspinski . . , H. Kaefferlein 1 1 4 1 , J. Hahn , J. P. Nony , P. , G. Zhou 3 2 , A. Islamzadeh , 1 2 and K. C. Donnelly , J. Wang , J. 2 1 National Research Centre for Environmental National Research Centre for Environmental 1 ChemRisk, Boulder, CO., CO., ChemRisk, Boulder, and PA ChemRisk, Pittsburgh, . Texas A&M University, College Station, TX, Station, College A&M University, Texas Baku, A.I. Karaev, n.a. Institute of Physiology Toxicology, The University of Queensland, Brisbane, of Queensland, The University Toxicology, Australia and QLD, J. Knutsen J. H. Finnell Mekhtiev and P. Scott and P. Australia. Sponsor: M. Kappler G. Zoubek 2 4 2 Services, Queensland Health, Brisbane, QLD, Z. S. Naufel 1 2 Azerbaijan and and Child Health, Beijing, China. EFFECTS IN AND GENOTOXIC EXPOSURE EXPOSED WORKERS ASPHALT MASTIC OF BITUMEN. AEROSOLS AND FUMES TO Bruening T. B. Marczynski B. and Germany Neuwied, CA. Francisco, AND PORPHYRINS ARSENIC, URINARY A POPULATION MALONDIALDEHYDE IN ARSENIC MITIGATION AFTER YEARS 16 C. Ng J. CHINA. IN XINJIANG, PROGRAM College Station, TX and TX Station, College Germany. LEVELS OF URINARY HIGH BACKGROUND FOUND IN BENZENE METABOLITES J. D. and S. H. Gaffney STUDY. VOLUNTEER CA. . ChemRisk, Inc., San Francisco, Paustenbach AND DIOXIN-LIKE OF PCDD/F EVALUATION FROM DATA CONCENTRATION PCB SERUM AND HEALTH THE 2001-2002 NATIONAL IN SURVEY NUTRITION EXAMINATION A. Harris M. THE UNITED STATES. Liu F. T. McDonald T. L. Pei MEASUREMENT OF EXPOSURE TO TO EXPOSURE MEASUREMENT OF OF POLYCYCLIC COMPLEX MIXTURES HUMAN IN HYDROCARBONS AROMATIC A. Lingenfelter R. POPULATIONS. Bochum, Germany, Bochum, Germany, Erlangen, Erlangen, Germany, and Environmental Health, Little Rock, AR, Health, Little Rock, and Environmental Rehabilitation, Sumgayit, Azerbaijan. Rehabilitation, Sumgayit, EXPOSURES OF GENOTOXIC ESTIMATION TUBE WITH NEURAL IN CHILDREN Z. S. Naufal CHINA. DEFECTS IN SHANXI,
(Continued) Annual Annual th #1252 #1255 #1253 #1254 #1250 #1251 45 160 . Meeting & ToxExpo & Meeting 1 , . . , R. 1 2 1 , 1 . 1 1 Dow Dow 2 J. , J. Bayer Bayer 1 3 Bayer Bayer WIL A. 2 2
, 1 NTP, NIEHS, NTP, 2 B. Muir B. , D. L. Rick , D. J. J. Keenan J. J. 1 K. L. Willett and K. L. and W. B. B. W. and 2 G. Wolfe and G. Toxicology and Toxicology 2 1 1 , D. A. Markham , D. . 1 3 and R. I. Krieger 1 J. L. Mattsson and J. 1 , S. Khan 1 M. S. Marty
, S. Pepperl X. Zhang 1 , 3 , M. D. Nemec , M. D. 1 , M. J. Bartels , M. J. 1 Orbitox, Santa Fe, NM and Santa Fe, Orbitox, , J. Weston , J. 1 J. M. Waechter, Jr. Waechter, M. J. 1 . 2 R. N. Shiotsuka and R. N. 2 , G. Leng , L. Murphy 2 F. Welsch F. 2 Brigham Young University-Hawaii, Laie, HI University-Hawaii, Young Brigham Bayer Industry Germany. Services, Leverkusen, Bayer 2 3 Toxicology & Environmental Research, The Research, & Environmental Toxicology of California, Riverside, University Entomology, Pharmacology and Environmental Toxicology, Toxicology, and Environmental Pharmacology of Mississippi, University Natural Product Center, Gene Logic, Gaithersburg, MD and MD Gaithersburg, Gene Logic, Research Laboratories, LLC, Ashland, OH. Ashland, Research Laboratories, LLC, REPRODUCTIVE MULTIGENERATIONAL ADMINISTERED AZT/3TC ASSESSMENT OF CD-1® MICE BY GAVAGE. TO Research Triangle Park, NC. Park, Triangle Research TOXICOLOGICAL ANALYSES OF ANALYSES TOXICOLOGICAL AND WATER MISSISSIPPI COASTAL SEDIMENT SAMPLES FOLLOWING Argote K. HURRICANE KATRINA. CropScience, Stilwell, KS. CropScience, Stilwell, IMPLICATIONS BIOMONITORING and Dow Chemical Company, Midland, MI and Midland, Chemical Company, Dow CYPERMETHRIN FOGGERS. S. Gold 1 CA, OF CHLORPYRIFOS (CPF) BLOOD DURING GESTATION PARTITIONING AND LACTATION. 1 University of Mississippi, University, MS and of Mississippi, University, University MS. University, ACCURACY AFFECTING FACTORS FROM IN EXPOSURE ESTIMATIONS BIOMONITORING A (BPA) BISPHENOL STUDIES. Chaudhary 1 2 The Research and Consulting, Environmental MI, Midland, Chemical Company, Dow Bishop 1 TWO-GENERATION REPRODUCTIVE REPRODUCTIVE TWO-GENERATION IN OF RESORCINOL STUDY TOXICITY RATS. AgroSciences LLC, Indianapolis, IN. THE INDOOR EXPOSURE IN PYRETHROID USE OF FOLLOWING ENVIRONMENT HealthCare AG, Wuppertal, Germany and Germany Wuppertal, AG, HealthCare M. Grundy J. Lawrence D. Beyer D.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#1245 Tuesday, March 7 March Tuesday, #1246 #1248 #1247 Attended: : Teresa Dodd-Butera, San Diego State University, San State University, San Diego Dodd-Butera, Teresa Chairperson(s): Research Health Research, for CIIT Centers Tan, CA and Cecelia Diego, NC. Park, Triangle Displayed: Exhibit Hall BIOMONITORING POSTER SESSION: 1:30 PM to 4:30 PM #1244
#1249 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1256 RELATION OF URINARY METABOLITES #1263 PREDICTING GC/MS TEQ FROM XDS- OF INORGANIC ARSENIC WITH CALUX® DETERMINATIONS OF DIOXIN TRANSFORMING GROWTH FACTOR CONTAMINATION IN SOIL. G. C. Clark1, J. ALPHA CONCENTRATION IN BLADDER Orelien2, J. D. Gordon1, A. C. Chu1, M. D. Chu3, UROTHELIAL CELLS FROM A POPULATION D. J. Brown4 and M. S. Denison5. 1Xenobiotic ENVIRONMENTALLY EXPOSED TO Detection Systems, Inc., Durham, NC, 2SciMetrika, INORGANIC ARSENIC. O. L. Valenzuela1, D. R. LLC., Research Triangle Park, NC, 3Analytical Germolec2, E. A. Garcia-Montalvo1, L. C. Sanchez- Perspectives, Wilmington, NC, 4Marietta College, Pena1, A. Hernandez-Zavala1, 3 and L. M. Del Razo1. Marietta, OH and 5Department of Environmental 1Toxicology, Cinvestav, Mexico D.F., Mexico, Toxicology, University of California, Davis, Davis, 2NIEH, Research Triangle Park, NC and 3INSP, CA. Cuernavaca, Mexico. #1264 DNA-PROTEIN CROSSLINKS AS #1257 BIOMARKERS OF AIR POLLUTION A POTENTIAL BIOMONITOR OF EXPOSURE - STUDY IN POLICEMEN IN HEXAVALENT CHROMIUM EXPOSURE PRAGUE. J. Topinka, B. Binkova, O. Sevastyanova, IN RAINBOW TROUT. K. N. Mellinger1, J. I. Chvatalova, A. Milcova, Z. Lnenickova, Z. R. Kuykendall1, K. L. Miller1, A. V. Cain1, B. L. Suchankova, I. Solansky and R. J. Sram. Genetic Finley2 and D. J. Paustenbach2. 1Raabe College of Ecotoxicology, Institute of Experimental Medicine Pharmacy, Ohio Northern University, Ada, OH and AS CR, Prague 4, Czech Republic. Sponsor: H. 2ChemRisk, San Francisco, CA. Autrup. #1265 COMPARISON OF NICKEL-INDUCED #1258 PATTERNS OF URINARY EXCRETION OF DNA-PROTEIN CROSSLINKS IN SEVERAL ARSENIC METABOLITES IN A POPULATION FRESHWATER FISH SPECIES AFTER ACUTE WITH LOW ARSENIC EXPOSURE. R. S. EXPOSURE. A. V. Cain, K. N. Mellinger, K. L. Kaetzel1, M. R. Edwards1, Y. W. Lowney2 and J. S. Miller, M. W. Mullen and J. R. Kuykendall. Raabe Tsuji1. 1Exponent, Bellevue, WA and 2Exponent, College of Pharmacy, Ohio Northern University, Boulder, CO. Ada, OH. Sponsor: B. Finley. #1259 STUDYING THE CYTO-GENETIC EFFECTS #1266 PERSISTENCE OF DNA-PROTEIN CROSS- IN WORKERS OCCUPATIONALLY EXPOSED LINKS IN ERYTHROCYTES OF CHANNEL TO VINCRISTINE WITH FOUR GENETIC CATFISH AFTER ACUTE HEXAVALENT TESTS. H. Jiliang, D. Hongping, Z. Meibian, W. CHROMIUM EXPOSURE. M. W. Perry1, J. R. Wei, J. Lifen, Z. Wei, L. Jianlin and W. Baohong. Kuykendall1, K. L. Miller1, K. N. Mellinger1, A. V. Institute of Occupational and Environmental Health, Cain1, B. L. Finley2 and D. J. Paustenbach2. 1Raabe Medical College, Zhejiang University, Hangzhou, College of Pharmacy, Ohio Northern University, Zhejiang, China. Ada, OH and 2ChemRisk, San Francisco, CA. #1260 DIETHYL PHTHALATE: A #1267 DIETARY HEXAVALENT CHROMIUM BIOMONITORING-BASED RISK EXPOSURE CAUSES DNA-PROTEIN ASSESSMENT. S. W. Robison, W. J. Greggs, A. CROSSLINK FORMATION IN E. Hochwalt, K. A. Kohrman, K. Kosemund, D. ERYTHROCYTES OF LARGEMOUTH BASS. A. McMillan and J. M. Naciff. Procter & Gamble, K. L. Miller, K. N. Mellinger, A. V. Cain and J. R. Cincinnati, OH. Kuykendall. Raabe College of Pharmacy, Ohio Northern University, Ada, OH. Sponsor: B. Finley. #1261 CONSERVATISM OF THE PESTICIDE HANDLERS EXPOSURE DATABASE: A COMPARISON WITH BIOMONITORING DATA FOR SIMILAR WORK TASKS. J. H. Ross1 and J. H. Driver2. 1infoscientific.com, Inc., 2 Carmichael, CA and infoscientific.com, Inc., TUESDAY Manassas, VA. #1262 PLACENTAL GLUTATHIONE-S- TRANSFERASE: ASSOCIATION OF GENOTYPE, ACTIVITY AND MATERNAL NUTRITION IN A MEXICAN OBSTETRIC POPULATION. T. Dodd-Butera1, P. Quintana1, M. Ramirez-Zetina2, M. Sierra1, C. Shaputnic1, S. Hull1, S. Ingmanson1 and A. C. Batista3. 1Graduate School of Public Health, SDSU, San Diego, CA, 2Instituto Mexicano de Seguro Social, Tijuana, Baja California, Mexico and 3Centros des Estudios Xochicalco, Tijuana, Baja California, Mexico. Sponsor: A. dePeyster.
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4 , M. S. Okino 1 Geo-Centers/Alion, Wright-Patterson AFB, AFB, Wright-Patterson Geo-Centers/Alion, 3 M. Lohitnavy , ISSUES IN USING MARKOV CHAIN MONTE ISSUES IN USING MARKOV PBPK A CALIBRATE TO ANALYSIS CARLO ASSESSMENT: MODEL FOR USE IN RISK WITH DICHLOROMETHANE CASE STUDIES R. T. AND PERCHLOROETHYLENE. Covington Health Research, Research Triangle Park, NC. Park, Triangle Health Research, Research A. Merrill Patterson AFB, OH, OH, AFB, Patterson for Risk Assessment, Cincinnati, OH and for Risk Department of Environmental Management, Department of Environmental Indianapolis, IN. IN OF PBPK MODELING APPLICATION ASSESSMENT OF 1, THE RISK OF SUPPORT 1-TRICHLOROETHANE. 1, H. J. Clewell and H. J. J. N. Blancato N. CHEMICALS. J. Evans HARMONIZED PBPK MODEL. Thompson Lu OH, OH and NEEDS. Teuschler Lipscomb NC and Consultant, Chapel Hill, Haskell . DuPont Valentine C. Leonard and R. Sciences, Laboratory for Health and Environmental DE. Newark, BETTER TO USING DOSE METRICS WHEN EXPOSURES IDENTIFY RELEVANT EXOGENOUS FROM ASSESSING IMPACTS Corporation, Ruston, LA and Research Corporation, Syracuse, NY, Research Corporation, Syracuse, NY, NC and Park, Triangle Research Computational Toxicology Group, Environmental Group, Environmental Toxicology Computational Colorado State Health Sciences, & Radiological Ft. Collins, CO. University, PBPK/PD USING HUMAN LIFE STAGE MODEL PREDICTIONS OF PERCHLORATE- TO INDUCED IODIDE INHIBITION ASSESSMENT IN SENSITIVE INFORM RISK POPULATIONS. EPA, Cincinnati, OH. EPA, FOR ANALYSIS CANCER DOSE-RESPONSE COMPARISON 3-BUTADIENE: 2-CHLORO-1, AND HUMAN EXPOSURE OF RODENT OUTCOMES USING PHYSIOLOGICALLY MODELING. BASED L. Kedderis A PHYSIOLOGICALLY BASED BASED A PHYSIOLOGICALLY MODEL OF PHARMACOKINETIC THE PREGNANT IN TRIHALOMETHANES OF KEY DATA IDENTIFICATION RAT: TRICHLOROETHYLENE CANCER TRICHLOROETHYLENE A USING ESTIMATES SLOPE FACTOR
(Continued) Annual Annual th #1280 #1278 #1276 #1279 #1275 #1274 #1277 45 162 , 2 Meeting & ToxExpo & Meeting
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R. Tardif and R. 2 R. A. Clewell R. Engineering, University of North Carolina at Chapel Engineering, University THE EFFECT OF UNCERTAINTY FACTOR FACTOR THE EFFECT OF UNCERTAINTY A PHYSIOLOGICALLY- IN PLACEMENT (PBPK) PHARMACOKINETIC BASED (TCE) TRICHLOROETHYLENE MODEL OF EXPOSURE GUIDELINE ACUTE FOR Krishnan Canada and and S. Borghoff NC. Park, Triangle Research A PHYSIOLOGICALLY- THE USE OF FOR APPROACH MODELING BASED THE MECHANISMS OF P-TERT- ASSESSING IN TOXICOKINETICS OCTYLPHENOL THE RAT. TRIHALOMETHANES EXPOSURE DATA BIOMONITORING FROM BASED WITH PHYSIOLOGICALLY MODELS. PHARMACOKINETIC PHARMOCOKINETIC DIFFERENCES OF IN LIFE-STAGES ACROSS PHTHALATES RATS. and S. Borghoff Hill, Chapel Hill, NC and . Standards Development Manca. Standards Development Balagopal and D. Branch, Ontario Ministry of the Environment, Canada. ON, Toronto, EXPLORE TO A PBPK MODEL USING MECHANISMS OF OBSERVED LEVELS (AEGL). Human Health Assessment, CIIT Centers for Health Human Health NC and Park, Triangle Research, Research Chemistry Council, Arlington, VA. Arlington, Chemistry Council, OF MTBE EXTRAPOLATION ROUTE IN RATS. PHARMACOKINETICS H. J. Clewell H. J. J. E. Simmons J. Research, Research Triangle Park, NC. Park, Triangle Research, Research HUMAN RECONSTRUCTING Research Triangle Park, NC. Park, Triangle Research OF REFERENCE DERIVATION DOSE- (RFC) FROM CONCENTRATION CHEMICAL FOR ANALYSIS (D-R) RESPONSE MIXTURES USING PHYSIOLOGICALLY (PBTK) MODEL. TOXICOKINETIC BASED Toxicology Division, U.S. EPA, Research Triangle Triangle Research EPA, U.S. Division, Toxicology NC and Park,
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 1:30 PM–3:00 PM
#1268 #1273 #1270 Attended: : Teresa Leavens, CIIT, Research Triangle Park, NC and Park, Triangle Research Leavens, CIIT, Teresa Chairperson(s): DE. Newark, Himmelstein, DuPont, Matthew Displayed: Exhibit Hall MODELS: PHYSIOLOGICALLY-BASED POSTER SESSION: APPLICATIONS Tuesday, March 7 March Tuesday, 1:30 PM to 4:30 PM
#1272 Program Description Description Program #1271 #1269
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Tuesday, March 7 #1288 SHORT-TERM EEG RECORDING IN 1:30 PM to 4:30 PM CONSCIOUS MONKEYS: COMPARISON Exhibit Hall OF NEEDLE ELECTRODES TO SURFACE ELECTRODES EMBEDDED IN A CAP. K. POSTER SESSION: SAFETY ASSESSMENT—METHODS AND Beard, M. Vezina and C. Copeman. Toxicology, MODELS Charles River Laboratories Preclinical Montréal, Senneville, QC, Canada. Chairperson(s): Dave McCormick, IIT Research Institute, Chicago, IL and #1289 David C. Dorman, CIIT Centers for Health Research, Research Triangle COMPARISON OF SHORT-TERM EEG Park, NC. RECORDINGS IN CONSCIOUS DOGS AND NON-HUMAN PRIMATES. K. Tenneson, M. Displayed: 1:30 PM–4:30 PM Vezina and C. Copeman. Toxicology, Charles River Laboratories Preclinical Montréal, Senneville, QC, Attended: 3:00 PM–4:30 PM Canada. #1281 THE INFLUENCE OF DISEASE ON THE #1290 TWO EXPERIMENTAL SCREENING TOXICOLOGICAL RESPONSE: ‘DISEASE MODELS OF RETINAL DEGENERATION IN MODEL TOXICOLOGY’ M. Foster, S. W. Ernst, THE LONG EVANS RAT. M. Vezina, A. Patel and K. Hickling, G. J. Oliver and M. Graham. Global C. Copeman. Toxicology, Charles River Laboratories Safety Assessment, AstraZeneca R&D Charnwood, Preclinical Montréal, Senneville, QC, Canada. Charnwood, United Kingdom. #1291 MULTIPLE-ENDPOINT CYTOTOXICITY #1282 SAFETY STRATEGIES IN DRUG DISCOVERY AND GENOTOXICITY ASSAY IN MOUSE SUPPORT. S. W. Ernst, M. Graham, M. Foster, S. C. L5178Y CELLS WITH LIMITED COMPOUND Boyer and G. J. Oliver. Global Safety Assessment, REQUIREMENTS. L. Recio1, M. Kehl1, J. AstraZeneca R&D Moelndal, Moelndal, Sweden. Winters1, C. Baldetti1, E. Livanos1 and P. Richter2. 1Genetic Toxicology, ILS, Research Triangle Park, #1283 ASSESSMENT OF THE POTENTIAL HEALTH NC and 2Office on Smoking and Health, CDC, RISK OF HUMAN PHARMACEUTICALS IN Atlanta, GA. THE ENVIRONMENT. S. P. Binks1, M. J. Olson2 and V. L. Cunningham3. 1Corporate Environment, #1292 INTRANASAL ADMINISTRATION Health & Safety, GlaxoSmithKline, Ware, TECHNIQUES FOR RODENTS AND LARGE Hertfordshire, United Kingdom, 2GlaxoSmithKline, ANIMALS. W. Lee, A. Viau and C. Banks. Research Triangle Park, NC and 3GlaxoSmithKline, Toxicology, Charles River Laboratories Preclinical King of Prussia, PA. Montréal, Senneville, QC, Canada. #1284 FEASIBILITY OF A TIERED APPROACH TO #1293 METHOD FOR REPEATED THE STANDARD 28-DAY TOXICITY STUDY INTRAVESICULAR INSTILLATION OF FOR PHARMACEUTICAL INTERMEDIATES. TEST ARTICLE IN TOXICOLOGY STUDIES. B. K. Shipp1, D. W. Moore2 and C. S. Schwartz1. W. Ruddock, S. Vachon and G. Washer. ITR 1Pfizer Global Environment, Health & Safety, Laboratories Canada Inc., Baie d’Urfe, QC, Canada. Occupational Toxicology & Hazard Assessment, Pfizer Inc., New York and 2PGRD Global #1294 5-BROMO-2’-DEOXYURIDINE DELIVERY Environment, Health & Safety, Pfizer Global METHOD INFLUENCES LABELING OF RAT Research & Development, Pfizer Inc., New London, NASAL EPITHELIUM CELLS. M. F. Struve, CT. S. A. Bumgardner, E. A. Gross and D. C. Dorman. Biological Sciences, CIIT Centers for Health #1285 THE USE OF PROTON AND CARBON- Research, Research Triangle Park, NC. 13 NMR TO IDENTIFY AND QUANTIFY COMPOUNDS FOR HIGH THROUGHPUT #1295 ASSESSMENT OF LIVER TOXICITY FOR TOXICITY SCREENING. S. Graves1, C. Smith2, J. REGULATORY PURPOSES. J. Schulze2 and C. Caffmeyer1 and W. Black1. 1Battelle, Columbus, OH Siegers1. 1Department of Experimental and Clinical TUESDAY and 2NIEHS, Research Triangle Park, NC. Pharmacology and Toxicology, Luebeck, Germany and 2Office of the Dean, Frankfurt/Main, Germany. #1286 CONTAMINATION OF CONTROL ANIMALS DURING REGULATORY TOXICOLOGY #1296 TACRINE HEPATOTOXICITY IN RODENT STUDIES: AVOIDANCE, ASSESSMENT AND MODELS. D. Evans1, A. Dahly-Vernon1, N. CONSEQUENCES. L. K. Earl and S. Crome. Cozzi1, S. Nye1, Y. Harrington1, J. O’Connor1, Huntingdon Life Sciences, Huntingdon, United A. Wittenburg1, S. Korb1, H. Vernon1, J. Baye1, Kingdom. Sponsor: C. Hardy. L. Lapczynski1, R. Roman1, 2 and H. Jacob1, 2. 1PhysioGenix, Milwaukee, WI and 2Medical College #1287 CEREBROSPINAL FLUID of Wisconsin, Milwaukee, WI. PHARMACOKINETIC: FLUOROSCOPY- GUIDED INTRATHECAL CATHETERS FOR REPEATED SAMPLING IN BEAGLE DOGS. I. Dean1, S. Authier1, 2 and E. Troncy2. 1LAB. Preclinical Research, Laval, QC, Canada and 2School of Veterinary Medicine, University of Montréal, St-Hyacinthe, QC, Canada. up-to-date information at www.toxicology.org 163
, 1 . and 1 and A. and , 1 1 . G. F. F. and G. 1 C. Banks Chemosensory , 1 1 . , G. J. Stevens , G. J. 2 2 Annual Meeting Annual S. Manetz J. E. Cometto-Muniz J. th Department of Chemistry, Department of Chemistry, 2 Analytical Research and Analytical 2 , K. Norton 1 , A. Deese , 1 SOT's 45 SOT's Worldwide Safety Sciences, Pfizer Safety Sciences, Worldwide 1 Covance, Muenster, Germany and Germany Muenster, Covance, 1 . , Universtiy of. Zuehlke , Universtiy 1 2 . and M. H. Abraham and M. H. Toxicology, Charles River Laboratories Charles River Toxicology, 1 1 1 , H. Penton 1 . , K. Palacio 2 1 Procter & Gamble Pharmaceuticals Procter & Gamble Inc., Cincinnati, VivoMetrics, Ventura, CA. Ventura, VivoMetrics, Development, PfizerDevelopment, Inc., La Jolla, CA. Preclinical Montréal, Senneville, QC, Canada and Preclinical Montréal, Senneville, Perception Laboratory, Department of Surgery Laboratory, Perception of California, San University (Otolaryngology), La Jolla, CA and Diego, H. S. Younis H. S. Weinbauer A GRAPHICAL EVALUATION METHOD A GRAPHICAL EVALUATION AND SERUM OF HEMATOLOGICAL FOR NON- BIOCHEMICAL PARAMETERS H. Yoneyama, A. Koga, T. STATISTICIANS. and R. Nagata S. Nagayama Yamada, T. Okatani, Collette Inc., La Jolla, CA and SNBL, Kagoshima, Japan. TERM (9-MONTH) CONTINUOUS LONG THE BEAGLE INFUSION IN INTRAVENOUS Gillis, C. T. C. Bosse, A. Patel, Armer, DOG. L. River Charles Toxicology, . Vezina Copeman and M. QC, Laboratories Preclinical Montréal, Senneville, Canada. WITH OILY SCREENING STUDIES IN DELIVERY VEHICLES FOR ORAL DRUG THE MARMOSET (CALLITHRIX JACCHUS) THE CYNOMOLGUS (MACACA AND S. H. Korte MONKEY. FASCICULARIS) 2 OH. FOR MOLECULAR DETERMINANTS DETECTION OF HUMAN EYE IRRITATION VAPORS HOMOLOGOUS CHEMICAL FROM EXPOSURES. ACUTE IN Kingdom. AND MAXIMUM RESPONSES HISTAMINE DOSE ENDPOINTS IN DOGS TOLERATED A. Lucock and STUDIES. TOXICITY USED ON Laboratories Ltd., Harrogate, . Covance Everett D. United Kingdom. CORRELATES PROFILING METABONOMIC TOXICITY MUSCLE WITH PPAR-MEDIATED W. W. PERIPHERAL EDEMA. NOT BUT VALIDATION OF AN AUTOMATED IN-VITRO IN-VITRO AUTOMATED AN OF VALIDATION IN CHO-K1 CELLS. ASSAY MICRONUCLEUS WA. Cerep, Redmond, Toxicology, Diaz. D. AND HIV HCV DETECTION OF HBV, TISSUE SAMPLES. B. IN ACIDS NUCLEIC S. Hickman, Zhang, Y. Wu, J. Tran, L. Anekella, and M. Manak. SeraCare BioServices, Steen D. Sponsor: MD. Gaithersburg, LIFESHIRTâ VIVOMETRICS THE USE OF DATA RESPIRATORY AMBULATORY FOR AND MONKEY. THE DOG COLLECTION IN S. Mason Derchak 2 W. S. Cain W. D. Eastman D. University College London, London, United College University
(Continued) Annual Annual th #1309 #1310 #1311 #1312 #1313 #1314 #1306 #1307 #1308 45 164 . Meeting & ToxExpo & Meeting , . 1 , 1, 2 1 , J. , J. 1 , . DSE, and 2 , N. , N. 1 S. Goel
, B. MacPherson , B. Medical College Medical College and H. Jacob , H. Vernon , H. 1 2 M. Hejtmancik 1 G. F. F. and G. A. Roberts 2 1, 2 , A. Dahly-Vernon , 1 Sinclair Research 1 Sound Pharmaceuticals F. J. Guerriero J. , F. 2 1 . 1 , S. Korb 1 S. Nye , D. Patten and A. and Patten , D. Green P. O. , J. Kil MD Kil , J. , , R. Roman 2 1 1 . Toxicology and Toxicology Lucas. and F. CEHS, GlaxoSmithKline, King CEHS, GlaxoSmithKline, Ware, Ware, CEHS, GlaxoSmithKline, 2 3 Corporate Environment Health Corporate Environment 1 M. J. Olson M. J. . . LAB. Pre-Clinical Research I. Dean. LAB. 3 , L. Brown DVM, Ph.D DVM, , L. Brown 1 , A. Wittenburg A. , 1 , Y. Harrington Y. , 1 , E. Lynch Ph.D , E. Lynch , L. Lapczynski 2 1 PhysioGenix, Milwaukee, WI and Milwaukee, PhysioGenix, of Prussia, PA and of Prussia, PA A VALIDATION FOR RESPIRATORY FOR RESPIRATORY VALIDATION A ASSESSMENT SAFETY PHARMACOLOGY Bassett, J. J. RATS. ANESTHETIZED IN International Inc., Laval, QC, Canada. International Inc., Laval, ASSESSING FOR OF METHOD VALIDATION OF INTRAVENOUSLY TOLERANCE LOCAL ADMINISTERED PHARMACEUTICAL ONE FIVE DAILY FOLLOWING AGENTS Bouchard DVM MS DACT DVM Bouchard C. W. Seaman W. C. Sanofi-Aventis Pharmaceuticals, Bridgewater, NJ. Pharmaceuticals, Bridgewater, Sanofi-Aventis A NEUROLOGICAL OF VALIDATION INCLUDING ASSESSMENT PANEL, THE AND TEST THE MODIFIED IRWIN BATTERY OBSERVATIONAL FUNCTIONAL C. Petit- RATS. (FOB) IN SPRAGUE-DAWLEY A. Chaurand, F. S. Fournier, Authier, S. Turcotte, R. D. Jones Johnson, R. D. OH. Huntingdon, United Kingdom. THE MEASUREMENT OF VALIDATION AND COMPLIANCE IN OF RESISTANCE A. Stonerook, S. M. J. THE CONSCIOUS RAT. Smith. Safety Pharmacology, P. Behringer and J. Battelle, Columbus, OH. Sponsor: HOUR INFUSIONS IN RABBITS. INFUSION MODEL. Zerouala and SYNTHESES. and Safety (CEHS), GlaxoSmithKline, Research NC, Park, Triangle Cozzi 1 NORMAL PHYSIOLOGICAL AND AND NORMAL PHYSIOLOGICAL THE FOR VALUES PATHOLOGICAL Peeper SWINE. H. J. SINCLAIR MINIATURE Ph.D Evans D. Pharmacology, Ricerca Biosciences, LLC, Concord, Ricerca Biosciences, LLC, Concord, Pharmacology, Baye Inc., Seattle, WA. Inc., Seattle, DETECT DIVERSE RATS GENETICALLY O’Connor J. TOXICITY. CLOFIBRATE C. Moore, E. Chacon and L. Carter. Covance Covance C. Moore, E. Chacon and L. Carter. VA. Vienna, Laboratories Inc., A SURGICALLY OF VALIDATION MOUSE INTRAVENOUS CANNULATED Hertfordshire, United Kingdom. THE IN TOXICOGENOMICS UTILITY OF THE HEPATOTOXIC OF ELUCIDATION A DISCONTINUED DRUG MECHANISM OF and Thompson C. CANDIDATE. Camacho. Toxicology, Huntingdon Life Sciences, Toxicology, Camacho. of Wisconsin, Milwaukee, WI. Milwaukee, Wisconsin, of HAZARD OCCUPATIONAL OF MUTAGENICITY DETERMINATION: IN DRUG INTERMEDIATES ISOLATED Center, Auxvasse, MO and Auxvasse, Center, J. Liu Ph.D J. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1315 CORRELATION AMONG Tuesday, March 7 CLINICOPATHOLOGICAL PARAMETERS 1:30 PM to 4:30 PM FOR MYOCARDIAL DAMAGE IN RATS Exhibit Hall TREATED WITH ISOPROTERENOL. M. Kurata, Y. Sasayama, T. Iidaka, T. Fukushima, M. POSTER SESSION: NUCLEAR RECEPTORS Sakimura and N. Shirai. Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Chairperson(s): William Baldwin, University of Texas at El Paso, El Paso, Laboratories, Pfizer Inc., Aichi, Japan. TX and Ruth Roberts, AstraZeneca UK, Macclesfield, United Kingdom.
#1316 CLINICAL PATHOLOGY VARIATIONS Displayed: 1:30 PM–4:30 PM BETWEEN TWO ORIGINS IN CYNOMOLGUS MONKEYS. H. Okatani, T. Koga, K. Nakama, H. Attended: 1:30 PM–3:00 PM Kadokura, T. Yamada, S. Nagayama, H. Tokado, #1321 ENHANCED ACETAMINOPHEN TOXICITY K. Fukuzaki, G. Kito and R. Nagata. Drug Safety BY ACTIVATION OF THE PREGNANE X Resarch Laboratories, Shin Nippon Biomedical RECEPTOR. G. L. guo2, 1, J. S. Moffit3, C. J. Nicol1, Laboratories, Kagoshima, Japan. J. M. Ward4, L. A. Aleksunes3, S. A. Kliewer5, J. #1317 EXTERNAL TELEMETRY INVESTIGATION E. Manauto3 and F. J. Gonzalez1. 11. OF ECG PARAMETERS FOR GROUP Laboratory of Metabolism, NCI, NIH, Bethesda, HOUSED NON-RODENT TOXICITY STUDIES. MD, 2Pharmacology, Toxicology and Therapeutics, G. Froget, A. Baleydier, A. Betat, P. Lainee and R. University of Kansas Medical Center, Kansas City, Forster. CIT, Evreux, France. KS, 32. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 43. #1318 COMPARATIVE ANALYSIS OF Veterinary and Tumor Pathology Section, NCI, CLINICAL PATHOLOGY DATA IN AGED Frederick, MD and 5Pharmacology, University of OVARIECTOMIZED/INTACT AND YOUNG Texas Southwestern Medical Center, Dallas, TX. ADULT FEMALE CYNOMOLGUS MONKEYS OF MAURITIAN ORIGIN. Universtiy of. Zuehlke #1322 ROLE OF NF-κB IN REGULATION OF and G. F. Weinbauer. Covance Laboratories GmbH, PXR TRANSCRIPTIONAL ACTIVITY: A Muenster, Germany. MECHANISM FOR THE SUPPRESSION OF PXR-MEDIATED CYTOCHROMES P450 #1319 PREDICTIVE IN VITRO STEM CELL EXPRESSION BY PROINFLAMMATORY HEMOTOXICOLOGY USING THE HALO AGENTS. X. Gu1, T. Sheng2, S. Ke1, L. J. PLATFORM FOR EARLY DRUG SCREENING Dangott3, P. E. Thomas4, M. A. Gallo4, W. Xie5 and AND ESTIMATING PRE-CLINICAL AND Y. Tian1. 1Department of Veterinary Physiology CLINICAL TRIAL DOSING. I. N. Rich and K. and Pharmacology, Texas A&M University, M. Hall. HemoGenix Inc., Colorado Springs, CO. College Station, TX, 2The University of Texas Sponsor: A. Vickers. Medical Branch, Galveston, TX, 3Department of Biochemistry & Biophysics, Texas A&M University, #1320 DETECTION OF INCREASED SENSITIVITY College Station, TX, 4EOHSI, Rutgers University, TO MULTIPLE DOSING AND RESIDUAL Piscataway, NJ and 5University of Pittsburgh, GROWTH POTENTIAL OF STEM CELLS Pittsburgh, PA. AFTER IN VITRO DRUG ADMINISTRATION USING THE HALO PREDICTIVE #1323 HORMONAL CONTROL SUPPORTS PLATFORM. I. N. Rich and K. M. Hall. XENOBIOTIC RECEPTOR MEDIATED HemoGenix Inc., Colorado Springs, CO. Sponsor: INDUCTION OF UGT1A1 IN TRANSGENIC A. Vickers. MICE. S. CHEN, D. Beaton, K. Senekeo- Effenberger and R. H. Tukey. Laboratory of Environmental Toxicology, Departments of Pharmacology and Chemistry & Biochemistry,
University of California, San Diego, La Jolla, CA. TUESDAY #1324 LIGAND-DEPENDENT ACTIVATION OF DAX-1 SILENCES ANDROGEN RECEPTOR- MEDIATED TRANSACTIVATION IN PROSTATE CANCER CELLS. S. Papineni1, S. Chintharlapalli2, E. Lalli3 and S. Safe1, 2, 4. 1Department of Veterinary Physiology and Pharmacology, Texas A&M University, College STation, TX, 2Department of Biochemistry and Biophysics, Texas A&M University, College STation, TX, 3Institut de Pharmacologie Moleculaire et Cellulaire, Texas A&M University, Sophia Antipolis, Valbonne, France and 4Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX. up-to-date information at www.toxicology.org 165
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, 2 , S. 1 and . 1 H. Kim , B κ L. D. Burgoon , L. D. L. D. Burgoon , L. D. C. D. Klaassen , C. D. 3 , L. M. Augustine , L. M. 1 Annual Meeting Annual th C. J. Fong C. J. N. J. Cherrington J. and N. 3 -ESTRADIOL ELICITED β , D. M. Nelson M. , D. 2 SOT's 45 SOT's Department of Pharmacology, Department of Pharmacology, 2 GENE EXPRESSION BY . Biochemistry Zacharewski and T. α J. Maher , J. 1 Pharmacology/Toxicology, University of Arizona, of University Pharmacology/Toxicology, Department Pharmacokinetics, of Metabolism and Toxicology and Therapeutics Center, University University Therapeutics Center, and Toxicology KS and Kansas City, of Kansas Medical Center, L. Lehman-McKeeman ACTIVATION OF NUCLEAR RECEPTORS OF NUCLEAR RECEPTORS ACTIVATION AND GARLIC AND NRF2 BY GARLIC CAR GENE CHANGES IN MOUSE HEPA-1C1C7 Fong C. J. Tan, Y. EXPRESSION. Tucson, AZ, Tucson, CT. Wallingford, Company, Squibb Bristol-Myers SERINE RAPID ESTROGEN-INDUCED AND ITS OF NRF-1 PHOSPHORYLATION OF THE GROWTH IN IMPLICATIONS J. J. IN MOUSE MACROPHAGES. ACTIVATION and M. Han, S. Han, S. Park Yoon, Y. Kang, . Environmental & Occupational Health, & Occupational Health, . Environmental Roy D. Miami, FL. Florida International University, OF ESTROGEN ANALYSIS PROMOTER . Biochemistry and Molecular R. Zacharewski and T. National Toxicolocy, Center for Integrative Biology, State Michigan Center, Toxicology Safety and Food East Lansing, MI. University, East Lansing, MI. TIME DEPENDENT MICROARRAY OF 17 ANALYSIS . Department of Biochemistry R. Zacharewski and T. Center for Integrative and Molecular Biology, Toxicology Safety and National Food Toxicology, East Lansing, State University, Michigan Center, MI. CHANGES IN TAMOXIFEN-INDUCED AGONIST GENE EXPRESSION: HEPATIC THIS OF ACTIVITIES ANTAGONIST AND RECEPTOR SELECTIVE ESTROGEN Benninghoff A. D. (SERM). MODULATOR and Molecular . Environmental Williams E. and D. OR. Corvallis, State University, Oregon Toxicology, RECEPTOR-INDEPENDENT ESTROGEN TUMOR NECROSIS INHIBITION OF FACTOR- CONSTITUENTS. C. fisher Bejati 1 3 Felty Zou, Q. Y. BREAST CANCER CELLS. Burt Humes, J. RESPONSIVE GENES. D. Center for Integrative and Molecular Biology, State University, and NFSTC, Michigan Toxicology, PHYTOESTROGEN EQUOL IS MEDIATED IS MEDIATED EQUOL PHYTOESTROGEN BY BLOCKING NUCLEAR FACTOR- Bioevaluation Center, Korea Research Institute of Korea Center, Bioevaluation South Korea. Taejon, Bioscience and Biotechnology, AND DOSE-RESPONSE TEMPORAL OF ANALYSIS UTERINE GENE EXPRESSION C57BL/6 MICE BY TREATED TAMOXIFEN MICROARRAY. CDNA L. Burgoon
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1 . , S. 2 . 1 and A. 2 . , 1 , X. Gu CIIT, CIIT, Department VTPP, Texas Texas VTPP, 1 2 2 1 . Molecular 1 L. You and L. 2 1 J. P. Hernandez P. , J. 1 and B. Cisneros- and B. 2 , D. D. Moore D. , D. A. D. Wallace and A. D. 2 , G. Elizondo 1 F. Zhang F. Y. Tian and Y. A. D. Wallace and A. D. 2 , W. Huang W. , 1 . Genetic and Molecular Biology Genetic and Molecular Biology 2 Biological Sciences, University Sciences, University Biological 1 , M. Bermudez B. A. Wasilak A. , B. L. M. Chapman 1 . 1 , M. Bedford 3 B. A. Wasilak A. B. M. Ema I. M. Medina-Diaz
, M. Negishi, K. Matsui and R. , M. Negishi, Tien E. Toxicology Section, Cinvestav, Mexico, Mexico, Section, Cinvestav, Toxicology 1 . 2 , W. Xie W. , 1 CIIT, Research Triangle Park, NC and Park, Triangle Research CIIT, PA. Pittsburgh, of Pittsburgh, University of Texas at El Paso, El Paso, TX and El Paso, at El Paso, Texas of Vega Ke Environmental and Molecular Toxicology, North Toxicology, and Molecular Environmental Raleigh, NC. Carolina State University, TRANSCRIPTIONAL THE OF ANALYSIS THE HUMAN REGION OF REGULATORY W. S. Baldwin W. R. Hasegawa, K. Kurose, K. Kurose, PXR (NR1I2) GENE. R. Hasegawa, Sawada. and J. Tohkin M. S. Koyano, S. Ikeda, Japan. Tokyo, National Institute of Health Sciences, Sponsor: PXR INFLUENCES CYP3A4 INDUCTION BY DEHP. 3 PXR-DEPENDENT INDUCTION OF CYP3A4 P’-DDT IN HEPG2 GENE EXPRESSION BY O, CELLS. 1 X. C. Kretschmer LIVER. A MIXED PREGNANE X RECEPTOR AND X RECEPTOR A MIXED PREGNANE AGONIST ALPHA RECEPTOR ESTROGEN CHOLESTEROL HEPATIC ALTERED AND INCREASED HOMEOSTASIS LIPOPROTEIN PLASMA HIGH DENSITY and Lee A1 IN MICE. J. APOLIPOPROTEIN and L. R. Curtis. Department of Environmental State University, Oregon Toxicology, Molecular OR. Corvallis, CAR THE NUCLEAR RECEPTOR THYROID ALTERS AND DIO1 REGULATES IN REGENERATING ACTIVITY HORMONE L. M. Tompkins L. M. A&M University, College Station, TX, Station, College A&M University, Moore. National Institute of Environmental Health of Environmental Moore. National Institute NC. Park, Triangle Sciences, Research A CONSTITUTIVE NONYLPHENOL IS (CAR) RECEPTOR ANDROSTANE ACTIVATOR. Department, Cinvestav, Mexico, DF, Mexico. DF, Mexico, Department, Cinvestav, OF REGULATION GLUCOCORTICOID Environmental and Molecular Toxicology, North Toxicology, and Molecular Environmental Raleigh, NC. Carolina State University, MECHANISM OF P38 MITOGEN-ACTIVATED THE IN INVOLVED KINASE PROTEIN RECEPTOR ANDROSTANE CONSTITUTIVE PATHWAY. SIGNALING Sierra-Santoyo of Carcinogenesis, The University of Texas M.D. M.D. Texas of The University of Carcinogenesis, TX and Smithville, Anderson Cancer Center, and Cellular Biology, Baylor College of Medicine, College Baylor and Cellular Biology, TX. Houston, SITES START TRANSCRIPTION UNIQUE AND PXR.2 IN HUMAN LIVER. FOR PXR.1 DF, Mexico and Mexico DF, Research Triangle Park, NC. Park, Triangle Research TRANSCRIPTIONAL OF REGULATION X OF HUMAN PREGNANE ACTIVITY ARGININE BY PROTEIN RECEPTOR Xie Y. METHYLTRANSFERASE(S). 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1327 Program Description Description Program #1332 #1329 #1328 #1330
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1341 PUTATIVE ROLE OF THE STEROID AND #1347 THE TRANSCRIPTION FACTOR NRF2 XENOBIOTIC RECEPTOR (SXR) IN THE CONTROLS THE EXPRESSION OF HEME MECHANISM OF HLA-DRα INDUCTION BY OXYGENASE-1 AND PHASE II-RELATED RIFAMPICIN. E. Fuentes-Mattei1, 3, L. Quattrochi2, GENES IN CELLS EXPOSED TO AQUEOUS J. Barwick2, P. S. Guzelian2 and B. D. Jimenez1, 3. EXTRACTS OF CIGARETTE SMOKE. A. 1Biochemistry, UPR Medical Sciences Campus, Hengstermann1, C. Knoerr-Wittmann1, S. Gebel1, J. San Juan, Puerto Rico, 2Gastroenterology/Medical Alam2 and T. Mueller1. 1PHILIP MORRIS Research Toxicology, University of Colorado Health Sciences Laboratories GmbH, Cologne, Germany and Center, Denver, CO and 3Center for Environmental 2Department of Molecular Genetics, Alton Ochsner And Toxicological Research, UPR Medical Sciences Clinic Foundation, New Orleans, LA. Sponsor: H. Campus, San Juan, Puerto Rico. Haussmann. #1348 MOUSE EMBRYONIC FIBROBLASTS Tuesday, March 7 FROM NRF2-DEFICIENT MICE DISPLAY 1:30 PM to 4:30 PM INCREASED OXIDATIVE DAMAGE Exhibit Hall FOLLOWING EXPOSURE TO DIQUAT. W. O. Osburn1, N. Wakabayashi1, T. Nilles2, V. POSTER SESSION: GENE REGULATION I Misra1, S. Biswal1, M. A. Trush1 and T. W. Kensler1. 1Environmental Health Sciences, Johns Hopkins Chairperson(s): Rao Uppu, Southern University, Baton Rouge, LA and University Bloomberg School of Public Health, Edward Puzas, University of Rochester School of Medicine, Rochester, NY. Baltimore, MD and 2Molecular Microbiology and Displayed: 1:30 PM–4:30 PM Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. Attended: 3:00 PM–4:30 PM #1349 INDUCTION OF RENAL HEME #1342 ARNT1 HAS A ROLE IN THE INNATE OXYGENASE-1 (HO-1) VIA NF-E2-RELATED IMMUNE RESPONSE IN HUMAN FACTOR 2 (NRF2) IN A RAT AND MOUSE KERATINOCYTES. K. N. De Abrew1, A. L. MODEL OF HEPATIC ISCHEMIA- Gibson2 and B. Allen-Hoffmann1, 2. 1Molecular REPERFUSION INJURY. Y. Tanaka, J. M. and Environmental Toxicology Center, University Maher, C. Chen and C. D. Klaassen. Pharmacology, of Wisconsin, Madison, WI and 2Pathology and University of Kansas Medical Center, Kansas City, Laboratory Medicine, University of Wisconsin, KS. Madison, WI. #1350 REGULATION OF METALLOTHIONEIN- #1343 BETA-TUBULIN INHIBITS THE HYPOXIA III GENE EXPRESSION BY PHYSICAL INDUCIBLE FACTOR-1ALPHA SIGNALING INTERACTION OF P53 WITH P300. H. G. Kim1, IN MCF7 CELLS. X. Wang, K. A. Jensen and W. 2 and H. Jeong1, 2. 1Pharmacy, Chosun University, K. Chan. Thomas J. Long School of Pharmacy and Kwangju, South Korea and 2Research Center for Health Sciences, University of the Pacific, Stockton, Proteineous Materials, Chosun University, Kwangju, CA. South Korea. #1344 MODULATION OF HYPOXIA-INDUCIBLE #1351 METALLOTHIONEIN-III UPREGULATES FACTOR MEDIATED GENE EXPRESSIONS HEME OXYGENASE-1 EXPRESSION VIA BY FLAVONOIDS. A. Lulla, L. Muppana and S. ACTIVATION OF NF-E2-RELATED FACTOR Park. St. John’s University, Queens, NY. 2 IN NEURO2A CELLS. Y. Hwang1 and H. Jeong1, 2. 1Pharmacy, Chosun University, Kwangju, #1345 HYPOXIA-INDUCIBLE FACTOR-1ALPHA South Korea and 2Research Center for Proteineous ACTIVATION BY METALLOTHIONEIN Materials, Chosun University, Kwangju, South IN THE HUMAN ENDOTHELIAL-LIKE Korea. ECV304 CELL LINE UNDER NORMOXIC 1, 2 1, 2 CONDITIONS. H. Kim and H. Jeong . #1352 REGULATION OF THE STEROIDOGENIC TUESDAY 1Pharmacy, Chosun University, Kwangju, South ACUTE REGULATORY PROTEIN (STAR) BY Korea and 2Research Center for Proteineous CYCLIC ADENOSINE MONOPHOSPHATE Materials, Chosun University, Kwangju, South (CAMP) AND TRANSFORMING GROWTH Korea. FACTOR-BETA (TGF-β) IN LARGEMOUTH BASS. M. S. Prucha1, R. J. Kocerha2 and N. D. #1346 HNF4ALPHA DYSFUNCTION IN DRUG- Denslow3. 1Pharmacology, University of Florida, INDUCED LIVER TOXICITY. J. Borlak and Gainesville, FL, 2Scripps Research Institute, West M. Niehof. Fraunhofer Institut of Toxicology and Palm Beach, FL and 3Physiological Sciences, Experimental Medicine, Hannover, Germany. University of Florida, Gainesville, FL. #1353 THE IDENTIFICATION OF HSF1- DEPENDENT GENE TRANSCRIPTION IN RESPONSE TO PROTEOTOXIC STRESS. T. Page1, L. Yang1, L. Pluta1, R. Wolfinger2 and R. Thomas1. 1CIIT, Research Triangle Park, NC and 2SAS Institute, Cary, NC. up-to-date information at www.toxicology.org 167 R.
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W. and W. K. Gaido 1 Cell Signaling 1 Center for . 2 1 and N. Kim and N. Annual Meeting Annual J. M. Maher , J. 1 , P. Stone , P. Microbiology, Boston Microbiology, 1 2 th R. C. Smart A. Slitt , 1 , P. Toselli , P. and 2 2 SOT's 45 SOT's D. B. Buckley B. D. I. Chou B. Copple B. Department of Pharmacy, Pusan Nation Department of Pharmacy, , 2 1 , K. Yoon , K. 1 . University of Kansas Klaassen. University and C. D. Biochemistry, Boston University School of Boston University Biochemistry, 1 . 1 Pharmacology, Toxicology, and Therapeutics, and Toxicology, Pharmacology, University of Kansas Medical Center, Kansas City, Kansas City, of Kansas Medical Center, University GENDER-DEPENDENT mRNA mRNA GENDER-DEPENDENT Y. Zhao Y. CIIT Centers for Health Research, Research Triangle Triangle Research Research, Health for Centers CIIT NC. Park, I OF BY NUCLEAR FACTOR REGULATION GENE EXPRESSION OXIDASE THE LYSYL IN RESPONSE LUNG FIBROBLASTS IN RAT FACTORS. ENVIRONMENTAL TO 1 KS and Busan, South Korea. University, QUINONE OF NAD(P)H UP-REGULATION 1 DURING HUMAN OXIDOREDUCTASE Aleksunes L. M. M. Goedken, LIVER INJURY. E. Manautou. Department Pharmacology and J. of Connecticut, Storrs, CT. Sciences., University Ranjan TO FOOTPRINTING VIVO USING IN TRANSCRIPTION ALTERED DETERMINE AFTER PHTHALATE BINDING FACTOR S. Ross and A. Kuhl, TREATMENT. Li Medicine, Boston, MA and EXPRESSION OF MOUSE UDP- (UGTS): GLUCURONOSYLTRANSFERASES AND ANDROGENS BY REGULATION HORMONE GROWTH MALE-PATTERN SECRETION. Cheng and Cancer Group, Department of Environmental and Cancer Group, Department of Environmental North Carolina Toxicology, and Molecular Raleigh, NC and State University, Medical Center, Kansas City, KS. Kansas City, Medical Center, A THROUGH ALPHA UVB-INDUCES C/EBP INVOLVING P53-INDEPENDENT PATHWAY FIBROBLASTS. IN PRIMARY C/EBP BETA University School of Medicine, Boston, MA. University RESPONSE FACTOR-1 GROWTH EARLY LIVER IS CRITICAL FOR CHOLESTATIC INJURY. Environmental and Genetic Medicine, Institute of and Genetic Medicine, Environmental TX. Houston, Technology, Biosciences and ONTOGENIC TISSUE DISTRIBUTION, OF AND REGULATION EXPRESSION BY PROTOTYPICAL SULFOTRANSFERASES Y. INDUCERS IN MICE. MICROSOMAL Klaassen. Pharmacology, Alnouti and C. D. M. of Kansas Therapeutics, University & Toxicology KS. Kansas City, Medical Center,
1:30 PM–4:30 PM 1:30 PM–3:00 PM (Continued) Annual Annual th #1361 #1365 #1367 Tuesday, March 7 March Tuesday, 1:30 PM to 4:30 PM Exhibit Hall II GENE REGULATION POSTER SESSION: Research Health Research, for CIIT Centers Gaido, Chairperson(s): Kevin of Cincinnati, Cincinnati, University Puga, Alvaro NC and Park, Triangle OH. Displayed: Attended: #1362 #1366 #1363 #1364 45 168
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. . 2 1 . and 2 Schering- , E. 2 1 Department 1 . 2 and K. Y. Lee Y. and K. 1 , M. Sordo . 1 G. D. Minsavage D. G. R. D. Snyder and R. D. Posgrado de la Facultad de la Facultad Posgrado 1 2 . Bioevaluation H. Kim. Bioevaluation . D. P. Jones P. and D. 2 and P. Ostrosky-Wegman and P. 1, 2 H. Kim Bionano Center, KRIBB, Taejeon, South Taejeon, KRIBB, Bionano Center, 2 , A. Vladimirova A. , , H. Zhang 1 1 -STIMULATED HUMAN UMBILICAL HUMAN UMBILICAL α-STIMULATED J. Kang, Y. Yoon, M. Yoon, Y. Kang, J. ACTIVATION. κB/REL Department of Medicine, Emory University, Department of Medicine, Emory University, Chemogenomics and Toxicology, Iconix Toxicology, and Chemogenomics Pharmacology, Chosun University, Kwangju, South Kwangju, Chosun University, Pharmacology, Instituto de Investigaciones Biomedicas, Instituto de Investigaciones of Pediatrics, Emory University, Atlanta, GA and Emory University, of Pediatrics, VEIN ENDOTHELIAL CELLS BY BLOCKING CELLS BY VEIN ENDOTHELIAL Atlanta, GA. NF- and Han, S. Han, S. Park 2 1 CA and View, Pharmaceuticals, Mountain ADHESION MOLECULE-1 EXPRESSION IN TNF- INHIBITION OF P65 NUCLEAR BY RADICICOL, TRANSLOCATION Jeon J. Y. HSP90 INHIBITOR. 1 and Korea Sponsor: Korea. EXPOSURE INCREASES NF- CROCIDOLITE THE INOS PROMOTER ON BINDING κB DNA Aust. A. E. and A549 CELLS. L. Buelow IN Utah State University, Chemistry and Biochemistry, Veranth Sponsor: J. UT. Logan, DRUG- BETWEEN RELATIONSHIP AND INDUCED INOS-2 GENE INDUCTION MECHANISTIC P450 GENE REPRESSION: CLASSES. AMONG DRUG DIFFERENCES MODULATION OF NF-KB, P53 AND P53 OF NF-KB, VIA MODULATION ARE/EPRE SIGNALING. P53 PROTEIN EXPRESSION IN HUMAN EXPRESSION P53 PROTEIN A. Salazar LYMPHOCYTES. Miranda-Gonzalez 1 Autonoma de Mexico, Nacional Universidad and Mexico D.F., Mexico, Center, Korea Research Institute of Bioscience and Korea Center, Korea. South Taejon, Biotechnology, TUMOR BY OXIDATION THIOREDOXIN-2 STIMULATION. FACTOR-ALPHA NECROSIS Hansen J. B. Ganter B. Plough Research Institute, Lafayette, NJ. Plough Research Institute, Lafayette, INTERCELLULAR SUPPRESSES GLABRIDIN PROTECTIVE ROLE OF CAFFEIC ROLE PROTECTIVE ESTER (CAPE) ON PHENETHYL ACID AGENT- ALKYLATING BI-FUNCTIONAL IN KERATINOCYTES TOXICITY INDUCED . Cell and Molecular Biology Branch, Dillman. Cell and Molecular Biology F. J. MD. Ground, Aberdeen Proving USAMRICD, de Quimica, Universidad Nacional Autonoma de Nacional de Quimica, Universidad States Sponsor: J. Mexico. D.F., Mexico Mexico, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1357 #1358 #1354 #1360 #1359 #1355
#1356 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1368 ETHANOL INDUCES AND INSULIN #1375 METAL INDUCED ACTIVATION OF INHIBITS ALCOHOL DEHYDROGENASE METALLOTHIONEIN GENE EXPRESSION. E. CLASS 1 IN FGC-4 CELLS: BOTH APPEAR S. Craft and J. H. Freedman. Nicholas School, Duke TO WORK THROUGH SREBP-1. L. He1, 3, F. University, Durham, NC. A. Simmen1, 3, M. J. Ronis2, 3 and T. M. Badger1, 3. 1Physiology & Biophysics, University of #1376 PB EXPOSURE REGULATES A COMPLEX Arkansas for Medical Sciences, Little Rock, INTERPLAY OF SIGNALING PATHWAYS AR, 2Pharmacology & Toxicology, University of IN ARTICULAR CHONDROCYTES Arkansas for Medical Sciences, Little Rock, AR and THAT ULTIMATELY LEADS TO 3Arkansas Children’s Nutrition Center, Little Rock, PHENOTYPIC CHANGES RESEMBLING AR. OSTEOARTHRITIS. M. J. Zuscik, E. Puzas, R. J. O’Keefe, T. Sheu, J. D. Holz, E. M. Schwarz, R. #1369 3, 3-DIINDOLYLMETHANE (DIM) DOWN- N. Rosier and R. Ubayawardena. Department of REGULATES THE CHEMOKINE, CXCL12, Orthopaedics, University of Rochester School of AND ITS RECEPTOR, CXCR4, IN BREAST Medicine, Rochester, NY. AND OVARIAN CANCER CELLS. E. L. Hsu, R. C. Aarnaes, S. Fawcett and O. Hankinson. Molecular #1377 EFFECTS OF CHROMIUM ON THE Toxicology, UCLA, Los Angeles, CA. BENZO[A]PYRENE-INDUCE GENE EXPRESSION IN MOUSE HEPATOMA #1370 FUNCTIONAL PROPERTIES OF HEPA-1 CELLS. M. Schnekenburger and A. Puga. AN ALTERNATIVE, TISSUE- Department of Environmental Health, University of SPECIFIC PROMOTER FOR THE Cincinnati, College of Medicine, Cincinnati, OH. N-ACETYLTRANSFERASE-1 GENE, NAT1. D. F. Barker, A. Husain, J. R. Neale, B. D. Martini, #1378 A CLEARANCE SYSTEM PROPOSED X. Zhang, M. A. Doll, J. States and D. W. Hein. FOR PARAQUAT-INDUCED PULMONARY 1, 2 1 Department of Pharmacology & Toxicology and FIBROSIS IN RATS. Y. Satomi , W. Tsuchiya , K. 2 1 1 1 Brown Cancer Center, University of Louisville, Mihara , M. Kobayashi , T. Kobayashi , Y. Kasahara 2 1 Louisville, KY. and F. Akahori . Teijin Institute for Bio-medical Research, TEIJIN PHARMA LIMITED, Tokyo, #1371 INDUCTION OF HEME OXYGENASE-1 Japan and 2School of Veterinary Medicine, Azabu EXPRESSION BY THE ISOFLAVONOIDS University, Kanagawa, Japan. ISOLATED FROM PUERARIA RADIX. C. Choi1, J. Kim2, 3, K. Oh2, 3, E. Han2, 3, Y. Hwang2, 3, #1379 MODULATION OF CALCINEURIN ACTIVITY D. Kim4 and H. Jeong2, 3. 1Division of Food Science, BY ZINC IN ADRIAMYCIN-TREATED Chinju International University, Chinju, South H9C2 RAT CARDIAC MUSCLE CELLS. 1 2 2 1, Korea, 2Pharmacy, Chosun University, Kwangju, K. E. Merten , Y. Jiang , W. Feng and Y. Kang 2 1 South Korea, 3Research Center for Proteineous . Pharmacology and Toxicology, University 2 Materials, Chosun University, Kwangju, South of Louisville, Louisville, KY and Medicine, Korea and 4Pathology, College of Oriental Medicine, University of Louisville, Louisville, KY. Daejeon University, Daejeon, South Korea. #1380 EFFECTS OF OXIDATIVE STRESS ON #1372 INDUCTION OF CYCLOOXYGENASE- G-PROTEIN-RECEPTOR-KINASE 2 2 BY GLUCOCORTICOIDS IN DEGRADATION. K. Hoffman, D. A. Jackson and CARDIOMYOCYTES. H. Sun. Pharmacology, D. M. Shepherd. Biomedical and Pharmaceutical University of Arizona, Tucson, AZ. Sciences, University of Montana, Missoula, MT. #1373 THE EFFECT OF CIGARETTE SMOKE #1381 HISTONE H3 PHOSPHORYLATION CONDENSATE ON RESPIRATORY PATTERNS IN RESPONSE TO DNA- SYNCYTIAL VIRUS INDUCED DAMAGING AGENTS. R. Xie, S. S. Lau and T. J. INFLAMMATORY CHEMOKINES. S. Castro1, 2, Monks. Pharmacology and Toxicolocy, University of 2 2 1 Arizona Health Sciences Center, Tucson, AZ. A. Casola and R. P. Garofalo . Pharmacology and TUESDAY Toxicology, University of Texas Medical Branch, #1382 REDOX SIGNALING AND SPATIAL RE- 2 Galveston, TX and Pediatrics, University of Texas ARRANGEMENT OF VE-CADHERIN, Medical Branch, Galveston, TX. Sponsor: M. ICAM-1, AND CD11B ADHESION Treinen-Moslen. MOLECULES ASSOCIATED WITH #1374 N27 DOPAMINERGIC CELL LINE: A USEFUL ALVEOLAR IRON CYCLING IN A MODEL MODEL FOR STUDYING THE MECHANISMS OF HEMORRHAGIC LUNG INJURY. N. V. 1 2 1 1 OF ACTION OF FUNCTIONALLY Gorbunov , D. K. Das and J. L. Atkins . MCR, SELECTIVE DOPAMINERGIC COMPOUNDS. Walter Reed Army Institute of Research, Silver 2 J. D. Urban1, J. Jin2 and R. B. Mailman3, 1. Spring, MD and School of Medicine, University of 1Curriculum in Toxicology, UNC Chapel Hill, Connecticut, Farmington, CT. 2 Chapel Hill, NC, Bioinformatics, UNC Chapel Hill, #1383 CHANGES IN CA2+ OSCILLATIONS 3 Chapel Hill, NC and Psychiatry, UNC Chapel Hill, IN HUMAN MYOMETRIAL CELLS Chapel Hill, NC. ASSOCIATED WITH TOXICANT EXPOSURE. R. Barhoumi, I. Awooda and R. C. Burghardt. Veterinary Integrative Biosciences, Texas A&M University, College Station, TX. up-to-date information at www.toxicology.org 169 ,
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2 , R. 1 1, 2 . and H. Jeong 3 Q. He , Q. . Annual Meeting Annual . th , D. Kim , D. A. M. Mayer
2, 1 Toxicology, Charles River Charles River Toxicology, M. Fukayama 1 Pharmacy, College of College Pharmacy, 1 . R. P. Sharma R. P. 2 . and P. B. Jacobson B. and P. 1 1, 2, 3 School of Dietetics and Human 2 , H. Kim SOT's 45 SOT's Metabolic Disease Research, Abbott Metabolic Disease Research, 1, 2 2 and T. Johns T. and , M. L. Hall Clinical Pharmacy, College of Medicine, College Clinical Pharmacy, 1 2 Research Center for Proteineous Materials, 2 , K. Oh 1, 2 1 and Y. Chen Y. and 1 Pharmacy, Chosun University, Kwangju, South Kwangju, Chosun University, Pharmacy, -INDUCED HEPATIC CYTOKINE CYTOKINE -INDUCED HEPATIC 1 1 Pharmacology, Midwestern University, Downers Downers University, Midwestern Pharmacology, . of Oriental Medicine, Daejeon College Pathology, Pharmacy, National Taiwan University Hospital, University Taiwan National Pharmacy, Korea, Korea, Medicine, National Taiwan University, Taipei, Taipei, University, Taiwan Medicine, National Taiwan, IMMUNOSTIMULATORY HERBAL HERBAL IMMUNOSTIMULATORY COLONY LUNG B16/F10 INHIBIT EXTRACTS IN IMMUNOCOMPETANT FORMATION IN MICE NOT C57BL/6 MICE BUT DEPLETED OF NK CELLS SELECTIVELY OR PERIPHERAL MACROPHAGES. Grove, IL and Grove, University, Daejeon, South Korea. University, CYTOKINE FUMONISIN MODULATES AND DIFFERENTIALLY EXPRESSION MITOGEN-ACTIVATED ACTIVATES IN MOUSE LIVER. KINASES PROTEIN T. Ueng T. Sponsor: Taiwan. Taipei, 1 Ibaraki, Japan. Sponsor: Woo E. ACTIVATION. AP-1 AND κB 2 3 DELETION OF INTERLEUKIN-12 GENE FUMONISIN ABROGATES IN MICE B Pharmacology, & Physiology Suzuki. H. and Sharma Athens, GA. of Georgia, University TNF- DIFFERENTIAL RELEASE OF 1 BY RAT TGF-BETA AND ALPHA COLI E. TO EXPOSED MICROGLIA 3 Groom QC, Canada and Vezina Canada. Sponsor: M. THE MECHANISM OF OF INVESTIGATION B-INDUCED INTERLEUKIN-6 RUBRATOXIN and K. H. Nakagawa H. Nagashima, SECRETION. Tsukuba, Research Institute, National Food Iwashita. Nutrition University of McGill, Montréal, QC, of McGill, Montréal, Nutrition University Laboratories, Abbott Park, IL. Abbott Park, Laboratories, ACTEOSIDE INHIBITS PHORBOL ACTEOSIDE ESTER-INDUCED CYCLOOXYGENASE-2 BLOCKING OF NF- THROUGH EXPRESSION THE MARINE AND LIPOPOLYSACCHARIDE ACID. DOMOIC TOXIN National Taiwan University, Taipei, Taiwan and Taiwan Taipei, University, Taiwan National R. P. Sharma Sharma and R. P. He, N. H. Suzuki, Q. of The University & Pharmacology, Physiology Athens, GA. Georgia, Chosun University, Kwangju, South Korea and South Korea Kwangju, Chosun University, S. Yu S. L. Peksa INDUCTION OF NECROSIS BY SAUROPUS BY SAUROPUS INDUCTION OF NECROSIS IN NIH3T3 FIBROBLASTS. ANDROGYNOUS ALTERATIONS WITHOUT REDUCING ALTERATIONS HEPATOTOXICITY. Laboratories Preclinical Montréal, Senneville, Laboratories Preclinical Montréal, Senneville, Kim J.
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3 1 G. S. Yost S. , G. , M. Kim 1 College of Pharmacy, of Pharmacy, College , T. A. Mobio T. , 1 1 and R. C. Scott. Safety . and S. D. Dano and S. D. 3 and S. D. Dano and S. D. K. Sathishkumar and E. E. Creppy A. S. Sabnis 2, 1 2, 1 , J. Yang , J. 1 Faculty of Pharmacy, of Pharmacy, Faculty Faculty of Pharmacy, of Pharmacy, Faculty 3 3 and S. Kim K. Kang , J. H. Kouadio , J. 1 1, 2 , S. Moukha , S. Moukha 1 1 UPR 1264 MycSA, INRA, Villenave Villenave UPR 1264 MycSA, INRA, UPR 1264 MycSA, INRA, Villenave Villenave UPR 1264 MycSA, INRA, 2 2 , E. Woo , E. 1 Toxicology, University Bordeaux 2, Bordeaux, University Toxicology, Research Center for Proteineous Materials, Chosun Toxicology, University Bordeaux 2, Bordeaux, University Toxicology, Chosun University, Gwangju, South Korea, South Korea, Gwangju, Chosun University, COMPARATIVE STUDY OF CYTOTOXICITY OF CYTOTOXICITY STUDY COMPARATIVE BY STRESS INDUCED AND OXIDATIVE ZEARALENONE DEOXYNIVALENOL, CELLS. OR FUMONISIN B1 IN CACO-2 J. E. Sidaway, P. D. Glaves, K. Lowry, F. Westwood, Westwood, F. K. Lowry, Glaves, D. P. E. Sidaway, J. 2 France, France, Liu and South Korea Gwangju, University, 1 Baudrimont 1 France, T. C. Orton A. M. Marsden, T. AstraZeneca, Macclefield, Cheshire, Assessment, United Kingdom. EPITHELIAL CELLS. CHOLESTEROL SECOALDEHYDE INDUCES SECOALDEHYDE CHOLESTEROL THROUGH SIGNALING APOPTOTIC IN H9C2 PATHWAY MITOCHONDRIAL CARDIOMYOBLASTS. and Health Toxicology M. Uppu. Environmental A&M and Southern University Research Center, Baton Rouge, LA. College, TRPM8 OF CHARACTERIZATION IN HUMAN RESPIRATORY RECEPTORS of Pharmacy and Research Center for Transgenic Transgenic of Pharmacy and Research Center for Cloned Pigs, Chungnam National University, Sponsor: H. Jeong Daejun, South Korea. E. E. Creppy . Pharmacology & Toxicology, University University Toxicology, & . Pharmacology A. Reilly C. UT. City, of Utah, Salt Lake AND PROTEIN GENE EXPRESSION STATIN- CHANGES DURING PRENYLATION THE RAT. IN TOXICITY INDUCED MUSCLE H. Kouadio d’Ornon, and France Abidjan Cote d’Ivoire, Abidjan, of University France. EFFECTS OF ANTI-OXIDATIVE ISOLATED QUERCETIN-GLYCOSIDES TUSSILAGO OF BUDS THE FLOWER FROM L. FARFARA d’Ornon, and France Abidjan, France. Abidjan, of University AND SYNERGISTIC ANTAGONISTIC AND EFFECTS OF ZEARALENONE FUMONISIN B1 IN HUMAN INTESTINAL CELLS LINE. CACO-2
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#1387 Attended: : Rhonda Rosengren, University of Otago, Dunedin, New Dunedin, New of Otago, University Chairperson(s): Rhonda Rosengren, France. Bordeaux, of Bordeaux, University Zealand and Edmond Creppy, Displayed: Exhibit Hall PRODUCTS NATURAL POSTER SESSION: Tuesday, March 7 March Tuesday, 1:30 PM to 4:30 PM #1385 #1384
#1386 Program Description Description Program #1389 #1388
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1397 NOTOGINSENG REDUCES LPS-INDUCED #1404 EFFECT OF FESCUE TOXICOSIS ON PRO-INFLAMMATORY MEDIATORS AND HEPATIC GENE EXPRESSION. R. S. Settivari1, LDL UPTAKE IN MURINE BONE MARROW- T. Evans2, E. Antoniou1, C. S. Reddy3 and D. E. DERIVED DENDRITIC CELLS. A. Rhule2, J. R. Spiers1. 1Animal Sciences, University of Missouri, Smith2 and D. M. Shepherd1, 2. 1CEHS, University Columbia, MO, 2Veterinary Medical Diagnostic of Montana, Missoula, MT and 2Biomedical & Laboratory, University of Missouri, Columbia, MO Pharmaceutical Sciences, University of Montana, and 3Veterinary Biomedical Sciences, University of Missoula, MT. Missouri, Columbia, MO. #1398 A NUTRIENT MIXTURE ATTENUATES #1405 THE ADDED EFFECTS OF HEAT STRESS ON ACETAMINOPHEN HEPATIC AND RENAL ALTERATIONS IN MURINE HEPATIC GENE TOXICITY IN ICR MICE. M. Roomi, V. Ivanov, EXPRESSION ASSOCIATED WITH FESCUE A. Niedzwiecki and M. Rath. Dr. Rath Research TOXICOSIS. S. S. Bhusari1, L. B. Hearne2, D. Institute, Santa Clara, CA. E. Spiers1, W. R. Lamberson1 and E. Antoniou1. 1Animal Science Research Center, University of #1399 THE COMBINATION OF CURCUMIN Missouri, Columbia, MO and 2Statistics, University AND EPIGALLOCATECHIN GALLATE of Missouri, Columbia, MO. Sponsor: T. Evans. SYNERGISTICALLY ELICITS G2 ARREST IN MDA-MB-231 HUMAN BREAST CANCER #1406 IDENTIFICATION OF ERGOTOXINS CELLS. R. J. Rosengren and T. Somers-Edgar. PRODUCED FROM ENDOPHYTE-INFECTED Pharmacology & Toxicology, Univeristy of Otago, TALL FESCUE AND PERENNIAL RYEGRASS. Dunedin, New Zealand. J. M. Duringer1, A. F. Lehner2, C. T. Estill3 and A. Craig3. 1Environmental and Molecular Toxicology, #1400 TUNGTUNGMADIC ACID, A NOVEL Oregon State University, Corvallis, OR, 2College ANTIOXIDANT, FROM SALICORNIA of Agriculture, Livestock Disease and Diagnostic 1 2 3 HERBACEA. Y. Chung , H. Chun , J. Kim , K. Center, University of Kentucky, Lexington, KY 3 3 2 3 1 Oh , Y. Hwang , Y. Kho and H. Jeong . Division and 3College of Veterinary Medicine, Oregon State of Food Science, Chinju International University, University, Corvallis, OR. Chinju, South Korea, 2Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea #1407 INHIBITORY EFFECT OF THE SAPONINS and 3Pharmacy, Chosun University, Kwangju, South DERIVED FROM ROOTS OF PLATYCODON Korea. GRANDIFLORUM ON CARRAGEENAN- INDUCED INFLAMMATION. S. Yang3, J. #1401 FRACTIONATION OF THE AQUEOUS Kim1, D. Kim3, Y. Hwang1, 2, K. Oh1, 2, Y. Chung4, EXTRACTS OF MEXICAN STRAIN S. Roh5 and H. Jeong1, 2. 1Pharmacy, Chosun OF LENTINUS LEPIDEUS WITH University, Kwangju, South Korea, 2Research Center IMMUNOMODULATING ACTIVITY. L. Garza- for Proteineous Materials, Chosun University, 1 1 2 1 Ocanas , R. Xochitl S. , G. Fortunato , A. Yolanda , Kwangju, South Korea, 3Pathology, College of 3 1 1 S. Mario Cesar and T. Oscar . Farmacologia Oriental Medicine, Daejeon University, Daejeon, y Toxicologia, Facultad de Medicina, UANL, South Korea, 4Division of Food Science, Chinju 2 Monterrey, Nuevo Leon, Mexico, Silvicultura, International University, Chinju, South Korea Facultad de Ciencias Forestales UANL, Monterrey, and 5Jangsaeng Doraji Research Institute of 3 Nuevo Leon, Mexico and Inmunologia, Facultad de Biotechnology, Jangsaeng Doraji Co., Ltd., Chinju, Medicina UANL, Monterrey, Nuevo Leon, Mexico. South Korea. #1402 STRUCTURE-ACTVITY STUDY OF #1408 INHIBITORY EFFECT OF THE FLAVONOIDS WITH MITOCHONDRIAL COFFEE DITERPENE KAHWEOL ON ENERGETIC PROCESS. D. Dorta, A. F. Calgaro- CARRAGEENAN-INDUCED INFLAMMATION Helena, S. C. Antonio and C. Curti. University IN RATS. D. Kim1, J. Kim2 and H. Jeong2. of Sao Paulo, Ribeirao Preto, Brazil. Sponsor: K. 1Pharmacy, Chosun University, Kwangju, South Wallace. Korea and 2Pathology, College of Oriental Medicine, TUESDAY #1403 18-β GLYCYRRHETINIC ACID- Daejeon University, Daejeon, South Korea. INDUCED HEPATIC EXPRESSION OF #1409 THE COFFEE DITERPENE KAHWEOL METALLOTHIONEIN IS MEDIATED BY INHIBITS TUMOR NECROSIS FACTOR- 1 1, 2 1, 2 CYTOKINES. H. Kim , K. Oh , H. Kim , J. -INDUCED EXPRESSION OF CELL 1, 2 1, 2 1, 2 3 α Kim , E. Han , Y. Hwang , D. Kim and H. ADHESION MOLECULES IN ENDOTHELIAL 1, 2 1 Jeong . Pharmacy, Chosun University, Kwangju, CELLS. D. Lim1, J. Choi1, 2, D. Kim3, J. Kim1, 2 South Korea, Research Center for Proteineous H. Kim1, 2, Y. Hwang1, 2, K. Lee1 and H. Jeong1, 2. Materials, Chosun University, Kwangju, South 1Pharmacy, Chosun University, Kwangju, South 3 Korea and Pathology, College of Oriental Medicine, Korea, 2College of Pharmacy, Research Center for Daejeon University, Daejeon, South Korea. Proteineous Materials, Chosun University, Kwangju, South Korea and 3Pathology, College of Oriental Medicine, Daejeon University, Daejeon, South Korea.
up-to-date information at www.toxicology.org 171
2 . M. , , L. 1 M. , 1 . 3 , 1 , A. , TOXBC, TOXBC, 1 1, 2 . 2 T. and T. 3 Columbus , S. A. Gerten , S. 2 , R. Harris 1 -MYRCENE 1 , A. , M. Shara D. N. N. D. β D. F. Gerken F. D. Midwest Research Midwest 1 , Y. Shibahara Y. , 1 . , S. W. Graves W. , S. 3 1 , K. Nabae Annual Meeting Annual NSF International, th 2 1, 2 and P. Chan and P. 2 , M. Nakamura 3 PharmaceuticalLoma Sciences, Caravan Products, Totawa, NJ. NJ. Totawa, Products, Caravan 1 Department of Experimental San-Ei Gen F.F.I., Inc., San-Ei Gen F.F.I., , S. Tamano , S. 3 2 3 1 . . 3 SOT's 45 SOT's and E. Waysek and E. , D. Orzech , D. 2 1 , T. Koda T. , 3 . Pharmacology and E. Gibson. Pharmacology and J. , D. Y. Vasconcelos Y. , D. 1 , N. Imai , N. 1 NIEHS, Research Triangle Park, NC. Park, Triangle NIEHS, Research . DIMS Institute of Medical Science, Inc., 2 1 . , M. Pan 2 2 Xenium Roundtable, Loma Linda, CA. Sponsor: Xenium Roundtable, Pathology and Tumor Biology, Nagoya City Nagoya Biology, Tumor and Pathology Graduate School of Medical Sciences, University Japan and Nagoya, Kerri Linda University, Loma Linda, CA, Linda University, FISCHER TO BY GAVAGE ADMINSTERED IN AND B6C3F1 MICE. 344 RATS Pharmacy Science, Creighton University, Omaha, Pharmacy Creighton University, Science, COLLABORATIVE LABORATORY STUDY STUDY LABORATORY COLLABORATIVE FLAVONOL DETERMINE TO A METHOD OF DIETARY IN GINKGO BILOBA AGLYCONES AND MATERIALS SUPPLEMENT CRUDE Gray D. FINISHED PRODUCTS. Y. Tsushima Y. OH and EFFECTS OF COMMERCIAL DIGESTIVE EFFECTS OF COMMERCIAL DIGESTIVE ON STARCH ACARBOSE AND AIDS Knecht T. FEEDING IN MICE. K. 3 Kadiiska NE. TOXICITY WEEK ORAL A FIFTY-TWO COLOR OF PURPLE SWEET POTATO STUDY Ichihara T. IN F344 RATS. Ichinomiya, Japan, Japan. Toyonaka, OF TOXICITY SUBCHRONIC R. Hejtmancik Inc., Columbus, Technology, Battelle Science and SPECIES USING PRESSURE CYCLING SPECIES USING PRESSURE MASS AND MALDI-TOF TECHNOLOGY Guthrie, J. Gray, R. Harris, D. SPECTROMETRY. Research Midwest L. Greene and S. Schwartz. Astroff Sponsor: B. MO. Institute, Kansas City, Astroff Sponsor: B. D. Bagchi A. Limpach, R. Sandstrom and D. Kincaid, Shirai TOXICITY IN CHO CELLS TOXICITY VITRO IN USED BY OF HERBS COMMONLY WOMEN. POSTMENOPAUSAL AND TERM SAFETY LONG OF NOVEL EVALUATION TOXICOLOGICAL CHROMIUM. NIACIN-BOUND Grove High School, Columbus Grove, OH and High School, Columbus Grove, Grove Sujjavanich School of Medicine at East The Brody Toxicology, NC. Greenville, Carolina University, M. J. Ryan M. J. Institute, Kansas City, MO, MO, Institute, Kansas City, BIOMARKER PROFILES OF ECHINACEA OF ECHINACEA BIOMARKER PROFILES Hagiwara and M. M. Knecht M. M. and Ann Arbor, MI and Arbor, Ann
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and 4 1, , 1 H. , J. , J. 1 Division Division 4 and 5 , J. Choi , J. and D. Kim and D. 2 , Y. Chung Y. , 1, 2 S. Roh Research Center , J. Y. Kim Y. , J. 2 1 2, 3 W. T. Barranco T. W. and C. Eckhert 1 , S. Roh 4 , C. Park 1 , H. Kim 1 Pharmacy, Chosun Pharmacy, Jangsaeng Doraji 1 5 Research Center for Division of Food Science, of Food Division , Y. Hwang Y. , . 3 3 2 4 Pharmacy, Chosun University, Chosun University, Pharmacy, 2 , Y. Chung Y. , 3 M. Yang M. , K. Lee 1 Division of Food Science, Chinju of Food Division 4 K. A. Henderson K. , K. Lee 2 Research Center for Proteineous Research Center for Proteineous 2 Jangsaeng Doraji Research Institute 1 , D. Kim , D. and S. Roh Jangsaeng Doraji Research Institute of 3 . , J. Kim , J. 4 Pharmacy, Chosun University, Kwangju, Kwangju, Chosun University, Pharmacy, 1, 2 1 Environmental Health Sciences, UCLA, Environmental 2, 3 1, 2 2 . Department of Microbiology, Hanyang Hanyang Department of Microbiology, Pathology, College of Oriental Medicine, of Oriental Medicine, College Pathology, 2 3 , J. Kim , J. 1, 2 College of Veterinary Medicine & Research Veterinary of College 2, 3 3 Department of Toxicology, Sookmyung Women’s Women’s Sookmyung Toxicology, Department of Angeles, UCLA, Los IDP, Toxicology Molecular , Y. Chung Y. , Jeong University, Kwangju, South Korea, South Korea, Kwangju, University, of Biotechnology, Jangsaeng Doraji Co., Ltd., Jangsaeng Doraji Co., of Biotechnology, Chinju, South Korea, CELL LINES. 1 CA and University College of Pharmacy, Seoul, South of Pharmacy, College University Korea, and ANTICARCINOGEGNIC EFFECTS OF PEARS. KOREAN 1 Choi PREVENTIVE EFFECT OF SAPONINS OF ROOTS DERIVED FROM GRANDIFLORUM PLATYCODON ON 4-(METHYLNITROSAMINO)-1-(3- LUNG PYRIDYL)-1-BUTANONE-INDUCED A/J MICE. TUMORIGENESIS IN Chinju, South Korea. International University, AND ANTIOXIDATIVE, ANTIMUTAGENIC, 2 Chinju, Jangsaeng Doraji Co., Ltd., Biotechnology, South Korea. SUPPRESSIVE EFFECTS OF THE SAPONINS OF SUPPRESSIVE EFFECTS OF PLATYCODON ROOTS DERIVED FROM OF ON EXPRESSION GRANDIFLORUM IN HUMAN ADHESION MOLECULES Cho Y. CELLS. ENDOTHELIAL H. Jeong H. Jeong Kwangju, South Korea, South Korea, Kwangju, Kwangju, Proteineous Materials, Chosun University, and South Korea Chinju International University, Chinju, South Chinju International University, and Korea and C. D. Eckhert. Molecular Toxicology, UCLA, Toxicology, Eckhert. Molecular and C. D. Angeles, CA. Los INDUCES ER STRESS IN ACID BORIC CANCER LNCAP PROSTATE AND DU-145 South Korea, South Korea, University College of Medicine, Seoul, South Korea of Medicine, Seoul, South Korea College University Institute of Veterinary Medicine, Chungbuk National Veterinary Institute of Cheongju, South Korea. University, OF BORIC MOLECULAR MANIFESTATIONS IN DU-145 TOXICITY ACID-INDUCED CANCER CELLS. PROSTATE Daejeon University, Daejeon, South Korea, Korea, South Daejeon, University, Daejeon Science, Chinju International University, of Food and Chinju, South Korea Materials, Chosun University, Kwangju, South Kwangju, Materials, Chosun University, Korea, for Proteineous Materials, Chosun University, for Proteineous Materials, Chosun University, South Korea, Kwangju, Los Angeles, CA. Los Research Institute of Biotechnology, Jangsaeng Research Institute of Biotechnology, Doraji Co., Ltd., Chinju, South Korea. THE EFFECTS OF INHIBITORY THE FROM ISOLATED POLYSACCHARIDES GRANDIFLORUM RADIX OF PLATYCODON AND METASTASIS. TUMOR INVASION ON Y. Hwang Y. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1415 Program Description Description Program #1414 #1411
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1423 LACK OF EFFECTS OF A TOMATO #1428 A RETROSPECTIVE REVIEW OF LYCOPENE PRODUCT, A NATURAL FOOD DEVELOPMENTAL NEUROTOXICITY COLOR, IN A 28-DAY ORAL TOXICITY STUDIES UTILIZING GAVAGE DOSING OF STUDY IN WISTAR RATS. Y. Doi1, 2, A. PRE-WEANING RATS DEMONSTRATES NO Hagiwara1, M. Kawabe1, Y. Toda1, T. Ichihara1, 2, N. ADVERSE CONSEQUENCES OF DOSING Inada3, A. Nishida3, Y. Sasaki3 and T. Shirai2. 1DIMS PROCEDURES ON BRAIN MORPHOMETRY. Institute of Medical Science, Inc., Ichinomiya, S. L. Makris1, K. M. Crofton2, J. Doherty3, K. Japan, 2Department of Experimental Pathology and C. Raffaele3, E. Mendez3 and K. Schumacher3. Tumor Biology, Nagoya City University Graduate 1ORD/NCEA, U.S. EPA, Washington, DC, 2ORD/ School of Medical Sciences, Nagoya, Japan and NHEERL, U.S. EPA, Research Triangle Park, NC 3San-Ei Gen F.F.I., Inc., Toyonaka, Japan. and 3OPP, U.S. EPA, Washington, DC. #1424 SCREENING OF NIGERIAN SHELLFISH #1429 ON THE USE OF NEURO-2A FOR “DIARRHETIC” TYPE SHELLFISH NEUROBLASTOMA CELLS VERSUS INTACT POISONING (DSP). I. Universtiy of. Asuzu and O. NEURONS IN PRIMARY CULTURE FOR O. Igboeli. Veterinary Physiology & Pharmacology, NEUROTOXICITY STUDIES. K. T. LePage1, W. University of Nigeria, Nsukka, Nsukka, Enugu, H. Gerwick2, R. W. Dickey3, E. L. Jester3 and T. F. Nigeria. Murray1. 1Physiology and Pharmacology, University of Georgia, Athens, GA, 2Oregon State University, Corvallis, OR and 3FDA Gulf Coast Seafood Tuesday, March 7 Laboratory, Dauphin Island, AL. 1:30 PM to 4:30 PM Exhibit Hall #1430 ONTOGENY OF PROTEINS ASSOCIATED WITH NEURITE GROWTH AND POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL SYNAPTOGENESIS IN CEREBELLAR GRANULE CELLS IN VITRO. W. R. Mundy, T. M. Chairperson(s): Susan Makris, U.S. EPA, Washington, DC and Henrik Freudenrich, B. L. Robinette and C. A. Rothermund. Viberg, Uppsala University, Uppsala, Sweden. Neurotoxicology Division, U.S. EPA, Research Displayed: 1:30 PM–4:30 PM Triangle Park, NC. #1431 AGE-DEPENDENT HEPATIC AND PLASMA Attended: 1:30 PM–3:00 PM METABOLISM OF DELTAMETHRIN IN #1425 EVALUATION OF LEARNING AND VITRO: ROLE IN ACUTE NEUROTOXICITY. MEMORY IN DEVELOPMENTAL S. S. Anand1, K. Kim1, S. Padilla3, S. Muralidhara1, NEUROTOXICITY STUDIES: COMPARISON H. J. Kim1, J. W. Fisher2 and J. V. Bruckner1. OF SINGLE-CHOICE WATER MAZE 1Department Pharmacology and Biom. Sciences., ACROSS LABORATORIES. K. Raffaele1, M. University Georgia, Athens, GA, 2Department Gilbert2, K. Crofton2, E. Mendez1, J. Doherty1, K. Environment Health Sciences., University Georgia, Schumacher1, W. Sette3 and S. Makris4. 1OPP, U.S. Athens, GA and 3Neurotox. Division, Universtiy EPA, Washington, DC, 2ORD, U.S. EPA, Research of.S.EPA, Research Triangle Park, NC. Triangle Park, NC, 3OSA, U.S. EPA, Washington, DC and 4ORD, U.S. EPA, Washington, DC. #1432 EFFECTS OF 6-PROPYL-2-THIOURACIL (PTU) ON THYROID GLAND MORPHOLOGY #1426 APPLICATION OF MAGNETIC RESONANCE AND THYROID HORMONE LEVELS IN IMAGING IN DEVELOPMENTAL WISTAR RATS AND THEIR OFFSPRING. S. NEUROTOXICITY TESTING: A PILOT Schneider1, W. Kaufmann1, B. van Ravenzwaay1, F. STUDY. K. Johnson1, L. Ryan2, J. Davis3, A. Hess2 and C. Hastings2. 1Experimental Toxicology Elmore3, B. Guenther2, J. Marcus1 and R. R. and Ecology, BASF AG, Ludwigshafen, Germany Maronpot1. 1Laboratory of Experimental Pathology, and 2Toxicology and Ecotoxicology, BASF NIEHS/NIH/DHHS, Research Triangle Park, NC, Corporation, Research Triangle Park, NC. 2MRPath, Durham, NC and 3Integrated Laboratory TUESDAY Systems, Research Triangle Park, NC. #1433 GENOMIC ANALYSIS OF PTU-INDUCED HYPOTHYROIDISM IN THE RAT #1427 HISTOLOGICAL STUDY FOCUSING ON HIPPOCAMPUS. J. E. Royland and M. E. Gilbert. THE FETAL BRAIN: EVALUATION OF A RAT Neurotoxicology Division, U.S. EPA, Durham, NC. AUTISM MODEL INDUCED BY VALPROATE AND THALIDOMIDE. T. Ogawa1, M. Kuwagata2, 1 #1434 DIFFERENT MECHANISMS IN and S. Shioda1. 1Anatomy, Showa University School PROSTAGLANDIN H SYNTHASE of Medicine, Shinagawa-ku, Japan and 2Pathology, (PHS)-CATALYZED OXIDATION OF Hatano Research Institute, FDSC, Kanagawa, Japan. CATECHOLAMINE NEUROTRANSMITTERS VS. 3, 4-METHYLENEDIOXYMETHAMPH ETAMINE AND METHAMPHETAMINE TO FREE RADICAL INTERMEDIATES. G. P. McCallum1 and P. G. Wells1, 2. 1Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada and 2Department of Pharmacology, University of Toronto, Toronto, ON, Canada. up-to-date information at www.toxicology.org 173 L. , 4 and
. , C. 1, 2, 3 , J. Furlong , J. 4 R. L. Carr , Medicine, Division Medicine, Division 1 . Center for . T. B. Cole B. T. Annual Meeting Annual . Center For R. L. Carr. Center For 1, 3, 2 , S. Proll th 2 and R. L. Carr S. X. Guo-Ross
, A. Abdel- A. , Abou-Donia M. B. Microbiology, University of University Microbiology, and 4 SOT's 45 SOT's , A. Forbes , 1, 3 Environmental and Occupational Environmental 2 and C. E. Furlong 2 Genome Sciences, University of Washington, Washington, of Genome Sciences, University 3 Environmental Health Sciences, Mississippi State Environmental MS State, MS. University, THE ORGANOPHOSPHOROUS EFFECTS OF AND INSECTICIDES CHLORPYRIFOS ON MUSCARINIC METHYL PARATHION BINDING RECEPTOR ACETYLCHOLINE IN BRAIN REGIONS OF POSTNATALLY RATS. TREATED EFFECTS OF REPEATED POSTNATAL POSTNATAL EFFECTS OF REPEATED AND CHLORPYRIFOS TO EXPOSURE ON BDNF LEVELS METHYL PARATHION AND HIPPOCAMPUS. CORTEX THE IN Pettan-Brewer NC. . Center for Environmental Health . Center for Environmental E. Chambers J. Mississippi Sciences, Mississippi State University, State, MS. POSTNATAL EFFECTS OF REPEATED CHLORPYRIFOS OR TO EXPOSURE THE ELEVATED IN METHYL PARATHION O. F. ANXIETY. PLUS-MAZE MODEL OF E. Chambers Johnson, J. J. Chambers J. Mississippi State, MS. Sponsor: A. M. Betancourt of Medical Genetics, University of Washington, Washington, of of Medical Genetics, University WA, Seattle, Environmental Health Sciences, Mississippi State Health Sciences, Mississippi Environmental Starkville, MS. University, OF LOW-LEVEL MODULATION TOXICITY ORGANOPHOSPHATE ASSESSED BY AS BY HUMAN PON1, ANALYSIS. MICROARRAY and WA Seattle, WA. Seattle, Washington, PERSISTENT NEUROBEHAVIORAL AND NEUROPATHOLOGICAL DEFICITS THE CEREBELLUM IN ALTERATIONS OFFSPRING FOLLOWING ADULT OF NICOTINE TO EXPOSURE MATERNAL AND IN ALONE AND CHLORPYRIFOS COMBINATION. Rahman, A. Dechkovskaia, L. B. Goldstein, S. L. B. A. Dechkovskaia, Rahman, and Cancer Khan. Pharmacology W. Bullman and Durham, Medical Center, University Duke Biology, CHRONIC DEVELOPMENTAL EXPOSURE EXPOSURE DEVELOPMENTAL CHRONIC ELEVATES ORGANOPHOSPHATES TO ALTERS AND LEVELS DOPAMINE SUBUNIT ACETYLCHOLINE NICOTINIC Brown. T. Eells and B. J. EXPRESSION. RNA Health Sciences, College Center for Environmental Medince, Mississippi State University, Veterinary of Costa G. Health Sciences, University of Washington, Seattle, Washington, of Health Sciences, University WA,
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IN Faculty Faculty D. , D. 1 . 1, 2 1, 2 D. Qiao , D. M. , 1 Center for 1 P. Lein P. . 1 , D. R. Goodlett , D. 2 , G. Giordano T. A. Slotkin and T. Department of 2 N. Moore N. P. G. Wells G. and P. 1 , S. Shaffer 2 D. B. Hood. Department B. and D. M. Guizzetti E. D. Levin , E. D. Environmental Health Sciences, Environmental and D. Bruun and D. Department of Environmental Department of Environmental Department of Pharmacology, Department of Pharmacology, 2 2 1 DISRUPTION OF VIA DISRUPTION 2 . 1 A. W. Wong W. A. F. J. Seidler J. R. R. Jameson, F. , B. Gallis , B. 1 L. A. Brown L. F. J. Seidler J. F. . , A. Howard 1 & Occupational Health Sciences, University of & Occupational Health Sciences, University and WA Seattle, Washington, Yang THE MORPHOGENIC ACTIVITY OF ACTIVITY THE MORPHOGENIC ACETYLCHOLINESTERASE. VIVO University of Toronto, Toronto, ON, Canada. ON, Toronto, Toronto, of University OF DEVELOPMENTAL DOWNREGULATION EXPRESSION OF IONOTROPHIC mRNA SUBUNITS RECEPTOR GLUTAMATE EXPOSURE GESTATIONAL FOLLOWING GENERATION BENZO(A)PYRENE IN F1 TO RATS. OUTCOMES DURING SPECIFIC CRITICAL PERIODS. A. Slotkin. Pharmacol/Cancer Biol, Duke and T. Durham, NC. of Med. Ctr, Universtiy AXON CHLORPYRIFOS INHIBITS OUTGROWTH . Department of Environmental Costa. Department of Environmental and L. G. of and Occupational Health Sciences, University WA. Seattle, Washington, DEVELOPMENTAL COMPARATIVE OF NEUROTOXICITY AND VITRO IN ORGANOPHOSPHATES of Biomedical Sciences, Division of Neurobiology of Neurobiology Division of Biomedical Sciences, Center for Molecular and and Neurotoxicology, Neuroscience, Meharry Behavioral College, Medical TN. Nashville, FOR APPROACHES USE OF PROTEOMIC IN OF CHANGES THE IDENTIFICATION SECRETION FOLLOWING ASTROCYTE ETHANOL EXPOSURE. Guizzetti Costa and L. G. THE ROLE OF OXIDATIVE DNA DAMAGE DAMAGE DNA OF OXIDATIVE THE ROLE IN METHAMPHETAMINE- AND REPAIR NEURODEVELOPMENTAL INITIATED DEFICITS. Medicinal Chemistry, University of Washington, Washington, of University Medicinal Chemistry, WA. Seattle, EFFECT OF ETHANOL ON CARBACHOL- IN INDUCED NEURITE OUTGROWTH NEURONS. HIPPOCAMPAL PRENATAL Research on Occupational and Environmental Research on Occupational and Environmental Health & Science University, Oregon Toxicology, OR and Portland, Superfund Basic Research Center, Duke University University Duke Superfund Basic Research Center, Durham, NC. Med. Ctr, AFFECTS NEURONOTYPIC CHLORPYRIFOS AND PHENOTYPIC CELL REPLICATION Johns Hopkins University Bloomberg School of Bloomberg Johns Hopkins University Health, Baltimore, MD. Public of Pharmacy, University of Toronto, Toronto, Toronto, Toronto, of University of Pharmacy, Canada and ON, K. L. VanDeMark, VanDeMark, K. L. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1440 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1448 EFFECTS OF GESTATIONAL TCDD #1454 BEHAVIORAL EFFECTS OF PERINATAL EXPOSURE ON NMDA/AMPA-DEPENDENT EXPOSURE TO PCB126 AND METHYL SINGLE CELL RESPONSES IN ADULT RAT MERCURY, ALONE AND IN ASSOCIATION. SENSORY CORTEX. D. B. Hood1, L. Woods2, A. Vitalone1, A. Catalani2, V. Chiodi2, C. Cinque2, V. S. Johnson1 and F. F. Ebner2. 1Department of Fattori1, A. Giacomi2, P. Matteucci2, A. Zuena2 and L. Biomedical Sciences, Division of Neurobiology Costa3, 4. 1University of Bari, Bari, Italy, 2University and Neurotoxicology, Center for Molecular and of Rome “La Sapienza”, Rome, Italy, 3University of Behavioral Neuroscience, Meharry Medical College, Washington, Seattle, WA and 4University of Parma, Nashville, TN and 2Department of Psychology, Parma, Italy. Vanderbilt University, Nashville, TN. #1455 ENHANCED DEVELOPMENTAL #1449 PRENATAL DIOXIN EXPOSURE DISRUPTS NEUROBEHAVIORAL DEFECTS IN MICE COCHLEAR FUNCTION IN MICE. T. M. Safe1, NEONATALLY CO-EXPOSED TO AN ORHTO- L. A. Opanashuk2 and A. E. Luebke1, 3. 1Biomedical SUBSTITUTED PCB (PCB 153), CO-PLANAR Engineering, University of Rochester Medical PCB (PCB 126), OR A BROMINATED FLAME Center, Rochester, NY, 2Environmental Medicine, RETARDANT (PBDE 99) IN ADDITION TO University of Rochester Medical Center, Rochester, METHYLMERCURY. C. Fischer, A. Fredriksson NY and 3Neurobiology & Anatomy, University of and P. Eriksson. Department of Environmental Rochester Medical Center, Rochester, NY. Toxicology, Uppsala University, Uppsala, Sweden. #1450 DEVELOPMENTAL EXPOSURE TO #1456 DECABROMINATED DIPHENYL ETHER AROCLOR 1254 IMPAIRS DENDRITIC (PBDE 209) INDUCES NEUROTOXIC PLASTICITY AND FUNCTIONAL EFFECTS IN THE NEONATAL AND ADULT EXPRESSION OF RYANODINE RECEPTORS MOUSE AFTER NEONATAL EXPOSURE. H. IN WEANLING RATS. D. Yang1, K. Kim2, A. Viberg1, N. Johansson1, A. Fredriksson1, J. Eriksson2 Phimister2, I. Pessah2 and P. Lein1. 1Center for and P. Eriksson1. 1Department of Environmental Research on Occupational and Environmental Toxicology, Uppsala University, Uppsala, Sweden Toxicology, Oregon Health & Science University, and 2Department of Environmental Chemistry, Portland, OR and 2Department of VM: Molecular Stockholm University, Stockholm, Sweden. Biosciences and Center for Childrens Environmental Health, University of California at Davis, Davis, #1457 ALTERED SYNAPTIC PLASTICITY CA. IN C57BL/6 MICE AFTER NEONATAL EXPOSURE TO BDE-47. M. Dingemans1, G. #1451 EFFECTS OF PERINATAL EXPOSURE TO Ramakers2, R. Westerink1, M. van den Berg1 and H. LOW DOSES OF PCB 153 ON THE BRAIN Vijverberg1. 1Institute for Risk Assessment Sciences, NEUROTRANSMITTERS OF FEMALE Utrecht University, Utrecht, Netherlands and 2Rudolf OFFSPRING AND MATERNAL RATS. T. Magnus Institute of Neuroscience, University Honma1, 3, M. Miyagawa1, R. Wang2, M. Suda3 and Medical Center Utrecht, Utrecht, Netherlands. K. Kobayashi3. 1Department of Research Planning, National Institute of Industrial Health, Kawasaki, #1458 NEONATAL EXPOSURE TO Japan, 2Department of Hazard Assessment, National PERFLUOROOCTANE SULFONATE (PFOS) Institute of Industrial Health, Kawasaki, Japan and AND PERFLUOROOCTANOIC ACID (PFOA) 3Department of Health Effect Research, National CAUSE DERANGED BEHAVIOUR AND Institute of Industrial Health, Kawasaki, Japan. INCREASED SUSCEPTIBILITY OF THE Sponsor: M. Chiba. CHOLINERGIC SYSTEM IN ADULT MICE. N. Johansson, A. Fredriksson and P. Eriksson. #1452 NANOMOLAR PCB 95 ALTERS IN Department of Environmental Toxicology, Uppsala VITRO NEUROPLASTICITY IN THE RAT University, Uppsala, Sweden. HIPPOCAMPAL SLICE PREPARATION AND LACTATIONAL EXPOSURE IN VIVO #1459 EFFECTS OF CHRONIC, LOW-DOSE ENHANCES SEIZURE SUSCEPTIBILITY. K. ACRYLAMIDE TREATMENT ON SPATIAL TUESDAY Kim1, S. Y. Inan2, R. F. Berman2 and I. N. Pessah1. LEARNING AND NEURODEVELOPMENT IN 1Center for Children s Environmental Health, FISCHER 344 RATS. J. Garey, S. A. Ferguson and Department of Molecular Biosciences: VM, M. G. Paule. Neurotoxicology, National Center for Universtiy of.C. Davis, Davis, CA and 2Department Toxicological Research/U.S. FDA, Jefferson, AR. of Neurological Surgery, UC Davis, Davis, CA. #1460 HYPERACTIVITY INDUCED BY EXPOSURE #1453 AUDITORY IMPAIRMENTS IN TO A PRENATAL GENOTOXIC AGENT, RATS EXPOSED TO PCBs DURING BRDU, ACROSS RODENT SPECIES, STRAINS 1, 2 1 DEVELOPMENT. B. E. Powers1, J. J. Widholm2, AND GENDER. M. Kuwagata , H. Ohmukai , 2 2 1 1 R. E. Lasky3, D. M. Gooler1 and S. L. Schantz1. T. Ogawa , S. Shioda and T. Nagata . Toxicology, 1Neuroscience, University of Illinois Universtiy of- Hatano Research Institute, Kanagawa, Japan and 2 C, Urbana, IL, 2Psychology, College of Charleston, Anatomy I, Showa University, School of Medicine, Charleston, SC and 3Health Science Center, Tokyo, Japan. University of Texas, Houston, TX.
up-to-date information at www.toxicology.org 175 , L. 1
M. , . 2 and 1 A.
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1 and . Center S. Karanth Department 1 and M. Ehrich Virginia-Maryland Virginia-Maryland 1 . 1 T. Kavanagh , T. 2 1 . D. Parran , D. B. S. Jortner S. , B. Annual Meeting Annual R. L. Carr 2 1 1
M. J. Pomeroy-Black M. J. th Biomedical Sciences and Via College of College Via 2 2 and C. Pope , A. A. Hirani A. , R. W. Biles W. , R. SOT's 45 SOT's 1 , K. Fuhrman 1, 2 1 M. F. Ehrich and M. F. , Z. Afsharinejad , Z. 2 1 Toxicology & Environmental Sciences, & Environmental Toxicology 1 and B. Rzigalinski and B. Environmental and Occupational Health Environmental . 1 1 2 VA MD Regional College of Vet. Med., Vet. of College MD Regional VA . 2 , Y. Lee Y. , 1 1, 2 Department of Biomedical Science and and Forensic Pharmacology Anatomy, Human 2 2 Biomedical Engineering and Sciences, Virginia Virginia Biomedical Engineering and Sciences, B. S. Jortner B. of Biology, LaGrange College, LaGrange, GA LaGrange College, of Biology, Regional College of Veterinary Medicine, Virginia Virginia Medicine, Veterinary of College Regional and VA Blacksburg, Tech, Sciences, University of Washington, Seattle, WA WA Seattle, Washington, of Sciences, University Meldrum and VA Blacksburg, Tech, ACETYLCHOLINE ACCUMULATION ACCUMULATION ACETYLCHOLINE VIVO RATS. ADULT OF IN STRIATUM J. Liu J. A. Ray, , Mirajkar N. 1 and Health M. Betancourt. Center for Environmental Mississippi Sciences, Mississippi State University, State, MS. SPECIES MEDIATE OXYGEN REACTIVE INDUCED BY THE NEUROTOXICITY INSECTICIDES IN ORGANOPHOSPHORUS MOUSE CEREBELLAR GRANULE CELLS. G. Giordano Costa and EFFECTS OF CHLORPYRIFOS ON AND ACTIVITY CHOLINESTERASE NJ and CHLORPYRIFOS INDUCES BBB UP-REGULATION THROUGH DISRUPTION IN MEDIATORS OF PRO-INFLAMMATORY ENDOTHELIAL BRAIN MICROVASCULAR Lee Y. CELLS. BLOOD-BRAIN BARRIER SYSTEM. BLOOD-BRAIN BARRIER for Veterinary Health Sciences, Oklahoma State Veterinary for OK. Stillwater, University, Pathobiology, Virginia Tech, Blacksburg, VA. Blacksburg, Tech, Virginia Pathobiology, IN SIGNALING INTRACELLULAR EARLY TO AFTER EXPOSURE SH-SY5Y CELLS AND NON-NEUROPATHIC NEUROPATHIC ORGANOPHOSPHATES. Osteopathic Medicine, Blacksburg, VA. Osteopathic Medicine, Blacksburg, DELAYED NEUROTOXICITY IN CHICKENS: IN CHICKENS: NEUROTOXICITY DELAYED WITH MOBIL JET OIL 254. STUDY 90-DAY Pathobiology, Virginia Tech, Blacksburg, VA. Blacksburg, Tech, Virginia Pathobiology, AND NGF GENE CHANGES IN BDNF SLICES EXPRESSION IN ORGANOTYPIC AND HIPPOCAMPUS THE CORTEX OF AND CHLORPYRIFOS TO EXPOSED CHLORPYRIFOS-OXON. of Parma Medical School, Medicine, University Parma, Italy. W. C. Daughtrey W. Ehrich F. Ehrich Virginia Tech, Blacksburg, VA. Blacksburg, Tech, Virginia OF ACTIVATION AND TRANSFER VITRO AN IN THROUGH MALATHION ExxonMobil Biomedical Sciences, Annandale, Sciences, ExxonMobil Biomedical
(Continued) Annual Annual th #1472 #1470 #1469 #1467 #1471 #1473 #1468 45 176 . Meeting & ToxExpo & Meeting 1 R. M.
B. S. B. T. , T. 3 S. S. J. , S. J. and
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M. B. and M. B. Division of Division 1 1, 2 Life Sciences 2 . F. Nasser F. , E. Pearson Pharmacology and Pharmacology 1, 2 1 2 R. J. Richardson and R. J. 2 , J. A. Stuckey , J. 1 Department of 2 T. V. Damodaran V. T. Toxicology Program, University University Program, Toxicology . Environmental . Environmental and A. Moretto Life Sciences Institute, University of of Life Sciences Institute, University 1 Pediatrics, Duke University Medical University Duke Pediatrics, 2 T. A. Patterson A. , T. 1 . M. G. Paule and M. G. , J. A. Stuckey , J. A. Nasser , F. 1 3 . 1 1 2 2, 1 M. Lotti Safety Assessment, AstraZeneca, Leics, United Assessment, Safety 3 Toxicology Program, University of Michigan, Ann of Michigan, University Program, Toxicology Michigan, Ann Arbor, MI. Arbor, Ann Michigan, DOMAIN OF THE PATATIN MODELING ESTERASE. TARGET NEUROPATHY , S. Hancock, J. Hinckley, J. Carter and J. Hinckley, , S. Hancock, J. Jortner MODELING THE CYCLIC NUCLEOTIDE THE CYCLIC NUCLEOTIDE MODELING BINDING DOMAINS OF NEUROPATHY ESTERASE (NTE). TARGET Wijeyesakere G. Hammond G. Nicolli, di Padova, Health, Universita’ Medicine and Public Italy. Padova, WALLERIAN- AND DYSTROPHY AXONAL MYELINATED TWO LIKE DEGENERATION. FIBER LESIONS OF MULTI- NERVE ORGANOPHOSPHATE-INDUCED EXPOSURE RATS. IN NEUROTOXICITY DELAYED DIFFERENTIAL EXPRESSION OF Abou-Donia Arbor, MI and Arbor, 1 Wijeyesakere and Kingdom. EVALUATION OF CHANGES IN OF CHANGES EVALUATION EXPRESSION GENE HIPPOCAMPAL THE BEHAVIORAL WITH ASSOCIATED BY CHRONIC CAUSED TOXICITY OR KETAMINE DEVELOPMENTAL RATS. IN TREATMENT REMACEMIDE Wright L. K. Cancer Biology and Pediatrics, Duke University University Duke and Pediatrics, Cancer Biology Durham, NC. Medical Center, AND ESTERASES PHENYL BENZOATE OF ORGANOPHOSPHATE PROMOTION A. (OPIDP). POLYNEUROPATHY DELAYED Institute, University of Michigan, Ann Arbor, MI. Arbor, Ann of Michigan, Institute, University MOLECULAR MECHANISMS IN OPIDN: THE CENTRAL SUBTYPES IN TUBULIN TREATED SYSTEM OF HENS NERVOUS WITH DIISOPROPYLPHOSPHOROFLUO (DFP). RIDATE Neurotoxicology, National Center for Toxicological Toxicological National Center for Neurotoxicology, AR, Research, Jefferson, . Laboratory Studies, Ehrich for Neurotoxicity F. VA. Blacksburg, Tech, Virginia Pharmacology and Toxicology, University of University Toxicology, and Pharmacology AR Little Rock, Arkansas for Medical Sciences, Center, Durham, NC, NC and Center, of Michigan, Ann Arbor, MI and Arbor, Ann of Michigan, J. Richardson J.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#1463 #1462 #1466 Attended: : Jean Claude Mwanza, U.S. EPA, Research Triangle Park Park Triangle Research EPA, U.S. Claude Mwanza, Chairperson(s): Jean MS. Mississippi State, Mississippi State University, and Russell Carr, Displayed: 1:30 PM to 4:30 PM Exhibit Hall PESTICIDES NEUROTOXICITY: POSTER SESSION: Tuesday, March 7 March Tuesday, #1461 #1465
#1464 Program Description Description Program
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1474 PARATHION-INDUCED CHANGES IN RAT #1482 THE MOLECULAR BASIS OF BRAIN REGIONAL CITRULLINE AND DIFFERENTIAL SENSITIVITY OF HIGH-ENERGY PHOSPHATE LEVELS COCKROACH VOLTAGE-SENSITIVE ARE ENHANCED BY SUGAR FEEDING. J. SODIUM CHANNELS TO INHIBITION BY Liu1, C. Pope1, S. Karanth1 and R. Gupta2. 1Center INDOXACARB. K. Silver, Y. Nomura and K. for Veterinary Health Sciences, Oklahoma State Dong. Entomology, Michigan State University, East University, Stillwater, OK and 2Murray State Lansing, MI. University, Hopkinsville, KY. #1483 PYRETHROID INDUCED ALTERATIONS #1475 CHLORPYRIFOS AND 3, 5, 6 TRICHLORO- IN TRANSCRIPTION OF CALCIUM 2-PYRIDINOL DISTRIBUTION IN RAT RESPONSIVE AND IMMEDIATE EARLY BLOOD AND BRAIN DURING CHRONIC GENES IN VIVO. J. A. Harrill1 and K. M. Crofton2, DIETARY AND REPEATED HIGH-LEVEL 1. 1Curriculum in Toxicology, University of North ACUTE EXPOSURE TO CHLORPYRIFOS. Carolina at Chapel Hill, Chapel Hill, NC and D. L. Hunter1, R. S. Marshall1, E. Reynolds2 and S. 2Neurotoxicology Division, U.S. EPA, Research Padilla1. 1NTD, U.S. EPA, Research Triangle Park, Triangle Park, NC. NC and 2St. Margaret’s School, Tappahannock, VA. #1484 THE ROLE OF OXIDATIVE STRESS IN #1476 AGE-RELATED DIFFERENCES OF THE NEUROTOXICITY OF MANCOZEB DETOXICATION AND INHIBITION AND MANEB. L. M. Domico1, G. D. Zeevalk2, B. FROM TWELVE ORGANOPHOSPHATE Buckley3, B. Winnik3, M. J. Thiruchelvam1 and K. COMPOUNDS. E. C. Meek1, R. Carr1, H. R. Cooper1. 1Joint Graduate Program in Toxicology, Chambers2, A. Coban1, B. Hurley1, J. Wagner1, J. Rutgers University, Piscataway, NJ, 2Neurology, Pittman1, K. White1 and C. Janice1. 1Center for UMDNJ, Piscataway, NJ and 3Environmental & Environmental Health Sciences, Mississippi State Occupational Health Sciences Institute, Rutgers/ University, Mississippi State, MS and 2Department UMDNJ, Piscataway, NJ. of Entomology, Mississippi State University, Mississippi State, MS. #1485 THE PROTECTIVE EFFECT OF BHT AGAINST MANCOZEB (MANGANESE-ZINC #1477 A SIMPLE HPLC METHOD FOR ETHYLENEBIS DITHIOCARBAMATE) DETECTING CARBARYL AND 1-NAPHTHOL INDUCED CYTOTOXICITY IN ASTROCYTES. IN BIOLOGICAL TISSUES. J. E. Graff, C. L. M. Tsang and L. D. Trombetta. Pharmaceutical Spivey and D. W. Herr. NTD/NHEERL/ORD, U.S. Sciences, St. John’s University, Jamaica, NY. EPA, Research Triangle Park, NC. #1486 EFFECTS ON STRIATAL #1478 RELATIONSHIPS BETWEEN TISSUE NEUROCHEMISTRY OF CHRONIC LEVELS OF CARBARYL, A PROTOTYPICAL ATRAZINE EXPOSURE INTERPHASED N-METHYL CARBAMATE PESTICIDE, WITH SHORT-TERM EXPOSURE TO AND CHOLINESTERASE INHIBITION IN MANEB. N. M. Filipov, A. B. Norwood, A. LONG EVANS RATS. D. W. Herr1, J. E. Graff1, R. Coban and S. C. Sistrunk. CEHS, Basic Sciences, S. Marshall1, A. B. Lowit2 and S. Padilla1. 1NTD/ Mississippi State University, Mississippi State, MS. NHEERL/ORD, U.S. EPA, Research Triangle Park, NC and 2HED/OPP/OPPTS, U.S. EPA, Washington, #1487 CHRONIC EXPOSURE TO ATRAZINE DC. MODULATES THE DOPAMINERGIC TOXICITY OF MPTP. A. B. Norwood, A. Coban, #1479 INHIBITION OF BRAIN CHOLINESTERASE S. C. Sistrunk and N. M. Filipov. CEHS, Basic AND THE PHOTIC AFTER DISCHARGE OF Sciences, Mississippi State University, Mississippi FLASH EVOKED POTENTIALS PRODUCED State, MS. BY CARBARYL IN LONG EVANS RATS. J. K. Mwanza2, J. E. Graff1, C. L. Spivey1 and D. W. Herr1. #1488 MECHANISMS OF ATRAZINE’S EFFECTS 1 ON BRAIN MONOAMINE FUNCTION. V. M. NTD/NHEERL/ORD, U.S. EPA, Research Triangle TUESDAY Park, NC and 2NRC, Washington, DC. Rodriguez, M. Thiruchelvam, J. K. Kochar and D. A. Cory-Slechta. Environmental and Community #1480 DELTAMETHRIN AND PERMETHRIN Medicine, Environmental and Occupational Health DECREASE SPONTANEOUS NETWORK Sciences Institute, The University of Medicine and ACTIVITY IN VITRO. S. Rijal1, G. W. Gross1 and Dentistry of New Jersey and Rutgers, Piscataway, T. J. Shafer2. 1Department of Biological Sciences NJ. and Center for Network Neuroscience, University of North Texas, Denton, TX and 2Neurotoxicology #1489 INCREASE OF DOPAMINE AND 5-HT Division, NHEERL, ORD, U.S. EPA, Research LEVELS AFTER AMITRAZ TREATMENT. Triangle Park, NC. M. A. Martinez, J. Del Pino, M. Marta, M. J. Diaz, V. Caballero, M. R. Martinez-Larranaga #1481 DIFFERENTIAL SENSITIVITY TO and A. Anadon. Department of Toxicology and PYRETHROIDS OF SODIUM CHANNEL Pharmacology, Complutense University, Madrid,
NaV1.2/β1 EXPRESSED IN XENOPUS Spain. OOCYTES. C. A. Meacham1, J. A. Watkins2 and T. J. Shafer1. 1Neurotoxicology, U.S. EPA, Durham, NC and 2Biochemistry, North Carolina State University, Raleigh, NC. up-to-date information at www.toxicology.org 177 - Annual Meeting Annual th SOT's 45 SOT's
Tuesday Evening Tuesday (Continued) Annual Annual th 6:00 PM to 8:30 PM Marriott Hotel & Marina 6:00 PM to 7:30 PM Room 10 SECTION MEETING/ SPECIALTY TOXICOLOGY IN WOMEN RECEPTION Women in Toxicology Members and friendsreception andare talk cordiallywith specialinvited guest to speaker a Joanne DeRitis ”Commu Tuesday, March 7 March Tuesday, 6:00 PM to 7:30 PM 6:00 PM to 7:30 PM Marina Ballroom D Marina Ballroom MEETING/RECEPTION: SPECIAL INTEREST GROUP SCIENCES TOXICOLOGICAL AFRICAN SOCIETY OF 7 March Tuesday, See Events Calendar on page 2–6 for Room Listings for 2–6 Calendar on page See Events FOOD SECTION MEETINGS/RECEPTIONS: SPECIALTY MOLECULAR BIOLOGY, METALS, , VITRO IN SAFETY, TOXICOLOGIC AND DEVELOPMENTAL, REPRODUCTIVE TOXICOLOGY IN WOMEN PATHOLOGY, AND EXPLORATORY 7 March Tuesday, Room Listings 2–6 for Calendar on page See Events CHAPTER MEETINGS/RECEPTIONS REGIONAL Many of the Regional Chapters meet Details for Chapter these receptions Regional and meetings are listed duringin the the SOT Annual Meeting. Calendar. Events 7 March Tuesday, nicating with Confidence.” Joanne isGroup Inc, Novations and has training provided aand personalized coaching Senior Training Consultant for to executives, leaders, sales teams, and technical professionals across the United States, Asia. Europe, Ms. and DeRitis confidentwill you how show communicators connect with their audience and get results. Learn the three most impactful skills that lead to openness, acceptance, and action. Identify back. that can hold you and minimize the common mistakes 45
178 - - - - Meeting & ToxExpo & Meeting , Annual SOT th R. C. MacPhail
RECEPTORS BY DIFFERENTIAL BY DIFFERENTIAL RECEPTORS A
FIPRONIL AND PICROTOXININ BLOCK AND PICROTOXININ FIPRONIL GABA and T. Yeh Z. MECHANISMS. X. Zhao, J. and Biological . Molecular Pharmacology Narahashi Chicago, IL. Northwestern University, Chemistry, OF NICOTINIC COMPARISON THE EFFECT IN BLOCKING ANTAGONISTS THE ON AND NICOTINE ANATOXIN-A OF OF RATS. ACTIVITY MOTOR J. D. Farmer and K. A. Jarema. NHEERL, U.S. EPA, EPA, Jarema. NHEERL, U.S. A. and K. Farmer D. J. NC. Park, Triangle Research
45th Annual Meeting and ToxExpo and Meeting Annual 45th
SOT ANNUAL BUSINESS MEETING BUSINESS ANNUAL SOT
Program Description Description Program and plans for the future. : Kendall Wallace, SOT President SOT Wallace, Chairperson(s): Kendall Members Only. SOT Members are invited and encouraged to attend the 45 Room 5B 4:30 PM to 6:00 PM Business Meeting. If you have long-range planning ideas that you like would added to the agenda, please send them to Shawn Lamb at SOT Head SOLUTIONS Corning Dow by Presented difficultare that materials laboratorya Need test? to by challenged you Are that can and develop validate methods? Or do you need regulatory compli 2:45 PM to 3:45 PM Room 11B AND CUSTOM SERVICES EXPERT SESSION: INFORMATIONAL Room 11A OF GENECHIP® APPLICATIONS SESSION: INFORMATIONAL TWO TOXICOGENOMICS—PART TECHNOLOGY FOR Affymetrix by Presented Customers will describe the use of GeneChip® microarray technology in their toxicological research. Affymetrix offers both RNA and DNA prod 2:45 PM to 3:45 PM #1491 #1490 quarters. The agenda includes a discussion of the Council planning 2006 session, financial a strategic of summary, review the 2005–2006 activities, Tuesday, March 7 March Tuesday, 7 March Tuesday, ucts on a single platform in multiplestandardization and labor cost reduction. Find out formats.how leading-edge scien Automation tools enable tists are streamlining and up powering their toxicogenomic with workflow Affymetrix. ance reviews for materials? forward. Come business moving experts and services your can help keep find out how Dow Corning EH&S Tuesday, March 7 March Tuesday,
TUESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday Morning Wednesday, March 8 9:00 AM to 12:00 NOON Room 6B
Wednesday, March 8 SYMPOSIUM SESSION: GENE-NUTRIENT-ENVIRONMENT- 8:00 AM to 8:50 AM INTERACTIONS AS RISK FACTORS FOR BIRTH DEFECTS: Room 6A FUMONISIN, FOLATE, GENETIC VARIATION AND NEURAL TUBE DEFECTS SOT/EUROTOX DEBATE: ‘OMICS’ RESEARCH DOES NOT ADD SUBSTANTIALLY TO THE SAFETY ASSESSMENT OF Chairperson(s): Janee Gelineau-van Waes, University of Nebraska CHEMICALS Medical Center, Omaha, NE and Ronald Riley, USDA, Athens, GA.
Motion: ‘Omics’ Research Does Not Add Substantially to the Safety Endorsed by: Assessment of Chemicals Food Safety SS* Mechanisms SS Endorsed by: Reproductive and Developmental Toxicology SS Society of Toxicology (SOT) European Societies of Toxicology (EUROTOX) The second most common birth defect is neural tube defects (NTDs). In Guatemala, parts of China and Africa, NTD risk is estimated to be higher Debaters: than that observed in the USA. The etiology of NTD in these areas is (Pro) EUROTOX: Alan Boobis, Imperial College London, London, United complex. Increased risk has been associated with genetic predisposition, Kingdom. dietary exposure to environmental contaminants, and reduced intake of folate and other vitamins/nutrients. Human clinical and epidemiological (Con) SOT: Dan Nebert, University of Cincinnati, Cincinnati, OH. studies show folate supplementation reduces the risk for NTDs. Fumoni- The 2006 Eurotox debate continues a very informative series in which sins are carcinogenic mycotoxins that cause farm animal diseases. They the points and respective counterpoints on a given topic are addressed by commonly contaminate maize and are suspected, but not proven, to cause well known toxicologists. Dr. Daniel W. Nebert and Prof. Alan R. Boobis human disease. Their mode of action involves inhibition of the enzyme will present differing views on the contribution of ‘omic’ technologies for (ceramide synthase) that controls the formation of sphingolipids; important assessing chemical safety as it applies to assessing human risk. regulators of pathways involved in cell death and survival. Sphingolipids are needed for the proper function of receptors associated with lipid rafts; for example, the folate-binding protein (Folbp1). Fumonisin disruption of Wednesday, March 8 folate transport via Folbp1 interferes with neural tube closure in animal 8:30 AM to 9:30 AM models in vitro and can be prevented by folate supplementation. In vivo Room 11B studies in LM/Bc and CD1 mouse strains have found that maternal fumo- nisin administration during pregnancy increases the frequency of NTD INFORMATIONAL SESSION: CARDIAC SAFETY—CURRENT in exposed embryos. Supplementation with folate or ganglioside GM1 is THINKING WHEN APPROACHING SAFETY ASSESSMENT protective, suggesting altered sphingolipid-dependent lipid raft function. In STUDIES addition, altered expression of cytokines, inducible nitric oxide synthase, Presented by Covance and several genes involved in redox homeostasis are observed in affected embryos. While there is no direct evidence for fumonisin as a cause of Adverse effects on cardiac safety have been responsible for several high- NTD in humans, the incidence of NTD is higher where maize consumption profile withdrawals, denied regulatory approvals and adverse labeling in is high and both fumonisin exposure and folate deficient diets are likely. human pharmaceuticals in recent years. This session will present current Epidemiological studies and further experimentation with animal models thinking on the electrophysiology of drug-induced QT prolongation, and a will be necessary to assess the teratogenic potential and impact of fumo- rational approach to the pre-clinical assessment of drugs for their potential nisin as a human health hazard. to produce this unwanted, and potentially dangerous, side effect. #1492 9:00 GENE-NUTRIENT-ENVIRONMENT INTERACTIONS AS RISK FACTORS FOR Wednesday, March 8 BIRTH DEFECTS: FUMONISIN, FOLATE, 8:30 AM to 9:30 AM GENETIC VARIATION AND NEURAL TUBE Room 11A DEFECTS. J. Gelineau-van Waes1 and R. T. Riley2. 1Center for Human Molecular Genetics, Nebraska INFORMATIONAL SESSION: MORPHOLINO ANTISENSE Medical Center, Omaha, NE and 2Toxicology and OLIGOS FOR BLOCKING TRANSLATION AND MODIFYING Mycotoxin Research Unit, USDA-ARS-SAA, SPLICING Athens, GA. Presented by Gene Tools #1493 9:10 THE RELATIONSHIP BETWEEN FOLATE DEFICIENCY, MAIZE CONSUMPTION, Morpholino antisense oligos knockdown genes by halting the initia- FUMONISIN INTAKE, AND GENETIC tion complex, preventing translation. Morpholinos can block pre-mRNA FACTORS ON NTD INCIDENCE splicing, producing messengers with introns included or exons missing. WORLDWIDE. M. Speer, A. Wise, J. R. Gilbert We will compare Morpholinos with other antisense (including siRNA), and J. Freedman. Duke University Medical Center, explain their mechanism of action, discuss delivery to the cytosol and show Durham, NC. Sponsor: J. Gelineau-van Waes. examples of their use. WEDNESDAY up-to-date information at www.toxicology.org 179 - - - S.
3 J. J. and , R. R. Veterinary & Veterinary
3 3 . , G. Flickinger 1 V. J. Johnson J. V. Annual Meeting Annual th , M. Rutherford 1 Mathematics & Statistics, Biochemistry & Molecular 2 1 . 3 , M. Mohrman 4 SOT's 45 SOT's Molecular Biosciences, University of of Molecular Biosciences, University 4 , A. L. Greene , 1 , C. Giulivi 2 .
California-Davis, Davis, CA. Davis, California-Davis, STRESS IN OF OXIDATIVE THE ROLE ASTHMA BY OF THE EXACERBATION A. E. Nel. AIR POLLUTION. PARTICULATE J. Angeles, CA. Sponsor: Medicine, UCLA, Los Regal University of Minnesota, Duluth, MN, of Minnesota, Duluth, MN, University PATHOGENESIS OF OCCUPATIONAL OF OCCUPATIONAL PATHOGENESIS Biology, University of Minnesota Medical School of Minnesota University Biology, Duluth, Duluth, MN, F. Regal F. D. I. Bernstein. Division of I. Bernstein. Division ASTHMA. D. of Cincinnati, University Immunology-Allergy, Regal J. Cincinnati, OH. Sponsor: and Molecular Biology Toxicology M. I. Luster. WV. Branch, NIOSH/CDC, Morgantown, AND EXPRESSION DIFFERENTIAL GENE MURINE MECHANISMS IN EFFECTOR ANHYDRIDE TRIMELLITIC MODELS OF ASTHMA. AND OVALBUMIN-INDUCED GENETIC SUSCEPTIBILITY AND OZONE GENETIC SUSCEPTIBILITY ASTHMA. ALLERGIC OF EXACERBATION USING MURINE MODELS TO UNDERSTAND UNDERSTAND TO USING MURINE MODELS TOLUENE OF BASIS THE IMMUNOLOGIC ASTHMA. DIISOCYANATE and J. Hendrickson and J. . Laboratory of RespiratoryR. Kleeberger Biology, NC. Park, Triangle NIH/NIEHS, Research Biomedical Sciences, University of Minnesota, St. of Minnesota, Biomedical Sciences, University MN and Paul, Regal
(Continued) Annual Annual th Mechanisms SS* #1501 10:40 #1498 9:10 Obesity as a Modulator of the Chemical overweight and obeseToxicity in In the US the have lastgrown from subpopulation fewto a ~60% relatively decadesof minor all adults. Even more alarming is the dramatic increase in the number of overweight epidemic is and linked to increases in obesethe incidences in disease, cardiovascular children. This obesity diabetes mellitus and certain forms of Adipose cancer. tissue is no longer considered a static depot of active excesstissue. Increases energyin adipose reservestissue, particularly but abdominal to an fat features endocrine-lead of insulin resistance syndrome, also syndrome referred X. This to syndrome as consists metabolic of a clustering of metabolic abnor 9:00 AM to 12:00 NOON 9:00 Room 6C OF A MODULATOR AS OBESITY SYMPOSIUM SESSION: TOXICITY CHEMICAL Chapel Hill, NC. EPA, Chairperson(s): Chris Corton, U.S. by: Endorsed #1500 10:10 #1502 11:10 #1499 9:40 malities that increase the disease. Adiposerisk tissue foralso secretes typea number 2 of diabetes low cytokines inflammatory leading andto state a cardiovascularin the obese. Additionally, with obesity higher is levels associated of insulin, insulin-like stress growththat are factor mechanistically linked to I carcinogenesis. andGiven that oxidativechem ical toxicity is often dependent on the same factors in levels the obese, that obesity may lead to an are of environment increased sensi at increased tivity to chemical-induced toxicity. In this symposium, the physiological, biochemical and molecular mechanisms that lead to metabolic syndrome X and changes in growth factors and cytokine secretion in the obese will be Wednesday, March 8 March Wednesday, 45 180 - - - , Meeting & ToxExpo & Meeting 1
2 USDA- 2 . 2
K. Voss , K. 1 . , L. Bauer 1 J. B. Gelineau-van Waes Gelineau-van B. J. J. F. Regal F. and J. 1 Biochemistry & Molecular 2 . Toxicology Toxicology . Riley T. and R. Genetics, Cell Biology & Anatomy, Anatomy, & Genetics, Cell Biology 1 . M. I. Luster 2
K. A. Voss A. K. , J. Wilberding , J. 1
Toxicology & Molecular Biology Branch, NIOSH, & Molecular Biology Toxicology Biology, University of Minnesota Medical School University Biology, Duluth, Duluth, MN. Nebraska Medical Center, Omaha, NE and Omaha, NE Nebraska Medical Center, ASTHMA. 1 Morgantown, WV and Morgantown, Athens, GA. Atlanta, GA. Sponsor: R. Riley and R. Riley FUMONISIN DISRUPTION OF FUMONISIN DISRUPTION AND ITS SPHINGOLIPID METABOLISM ANIMAL AND IN HUMAN IMPLICATIONS DISEASE. Unit, USDA-ARS-SAA, Research and Mycotoxin Athens, GA. INHIBITION OF FUMONISIN B1-INDUCED VITAMIN RECEPTOR-MEDIATED FOLATE and Epidemiology L. Stevens. V. UPTAKE. Cancer Society, American Surveillance Research, ARS Toxicology & Mycotoxin Research Unit, & Mycotoxin Toxicology ARS MODELS AND MECHANISMS OF AND MODELS OCCUPATIONAL/ENVIRONMENTAL MATERNAL FUMONISIN EXPOSURE AND EXPOSURE FUMONISIN MATERNAL MECHANISMS TUBE DEFECTS: NEURAL A MOUSE MODEL. IN J. Maddox J. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
Occupational and Public Health SS Occupational and Public Inhalation SS Immunotoxicology SS* Immunotoxicology Occupational asthma is defined limitation and bronchial airflow as variable hyperresponsiveness due to causes and conditions encountered in a work : Jean Regal, University of Minnesota, Duluth, MN and of Minnesota, Duluth, MN and University Regal, Chairperson(s): Jean WV. CDC-NIOSH, Morgantown, Luster, Michael by: Endorsed Room 6F AND MECHANISMS OF MODELS SYMPOSIUM SESSION: ASTHMA OCCUPATIONAL/ENVIRONMENTAL Wednesday, March 8 March Wednesday, AM to 12:00 NOON 9:00 #1495 10:30 #1494 9:50 place environment. A myriad of substances are responsible for occupational for responsible are substances of myriad A environment. place asthma, including low molecular weight chemicals and protein allergens. Though asthma is treated as a single lung disorder, it is increasingly clear that the pathophysiology of asthma may differ substantially depending on the allergen, exposure conditions and environmental triggers. Diagnostic, immunologic and genetic factors associated with disease development are being actively investigated. Animal models for occupational being to developed define mechanisms asthmaof this lung disorder and determine are more effective methods for prevention, diagnosis and treatment of pational occu asthma. Both toluene diisocyanate and trimellitic prototype low anhydride molecular weight arechemicals that cause asthma in the work place, and studies defining the effector mechanisms for these allergens are being investigated. Environmental factors such as ozone air pollution and can particulateexacerbate existing asthma and profoundly influence the pathophysiology and clinical outcome. Understanding the interactions of environmental and genetic factors is alsopopulations important at to risk. defineContinued potential studiesmodels are inneeded to the more workplace clearly diagnose, anddefine treat this important health problem. public inand triggers, and effectively the pathophysiology animal #1497 9:00
#1496 11:10 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) discussed. A number of examples in rodent models will be given, in which two talks will address activation of MAPKs in response to metal exposure obesity clearly alters chemical toxicity in a number of tissues. The infor- irrespective of changes in redox state, as observed with Zn and Cr(VI) in mation presented in this symposium will highlight the fact that the obese human airway epithelium. Zn induces activation of ERK1/2, JNK and p38 should be evaluated as a sensitive population. and the tyrosine kinase receptor, EGFR. Modulation of ERK1/2 and EGFR #1503 9:00 OBESITY AS A MODULATOR OF CHEMICAL involves multiple levels of activation, including EGFR transactivation by TOXICITY. J. C. Corton. NHEERL, U.S. EPA, Src and metalloprotease activation. Finally, other studies on airway epithe- Research Triangle Park, NC. lium have examined signaling pathways by which Cr(VI), at non-cytotoxic concentrations, selectively induces and silences genes. Cr stimulates Src #1504 9:05 OBESITY AS A MODIFIER OF CHEMICAL family kinases (SFK) Lck and Fyn, but not Src or Yes, and stimulation of TOXICITY - HISTORICAL PERSPECTIVE. SFKs leads to selective activation of JNK. However, although Cr induces G. Corcoran1 and C. Corton2. 1Department of ROS generation, SFK-dependent JNK activation occurs independent of Pharmaceutical Sciences, Wayne State University, metal-induced oxidative stress. 2 Detroit, MI and NHEERL, U.S. EPA, Research #1509 9:00 THE ROLE OF MAP KINASES IN METAL Triangle Park, NC. TOXICITY. A. R. Villalobos. Environmental #1505 9:40 OBESITY, METABOLIC SYNDROME X AND Medicine, University of Rochester, Rochester, NY. INFLAMMATION. P. Dandona. SUNY-Buffalo, #1510 9:05 MAP KINASE SIGNALING CASCADES. M. Buffalo, NY. Sponsor: C. Corton. H. Cobb. Pharmacology, The University of Texas #1506 10:15 DIET-INDUCED DIABETES AS A Southwestern Medical Center at Dallas, Dallas, TX. MODULATOR OF CHEMICAL TOXICITY Sponsor: A. Villalobos. IN THE LIVER. H. Mehendale. Department of #1511 9:40 MAP KINASE ACTIVATION AND METALS: Toxicology, University of Louisiana, Monroe, LA. ALTERED REDOX STATE OR ENZYME #1507 10:50 OBESITY AND INCREASED MODIFICATION? H. J. Forman. UC Merced, SUSCEPTIBILITY TO CHEMICALLY- Merced, CA. Sponsor: A. Villalobos. INDUCED NEURODEGENERATION. J. #1512 10:15 METAL-INDUCED OXIDATIVE STRESS AND O’Callaghan. CDC-NIOSH, Morgantown, WV. CELLULAR RESPONSES. X. Shi. NIOSH, #1508 11:25 DIET, OBESITY AND CHEMICAL Morgantown, WV. Sponsor: A. Villalobos. CARCINOGENESIS: EXPERIMENTAL #1513 10:50 ZN2+-INDUCED MAPK AND EGFR APPROACHES. S. Hursting. NCI, Rockville, MD. ACTIVATION IN HUMAN AIRWAY Sponsor: C. Corton. EPITHELIAL CELLS (HAEC) ARE MEDIATED BY PHOSPHATASE INHIBITION. Wednesday, March 8 J. M. Samet1, 3, Y. Kim2, T. Tal3, P. Bromberg2, 9:00 AM to 12:00 NOON W. Wu2 and L. M. Graves2, 3. 1Human Studies Room 7B Division, U.S. EPA, Chapel Hill, NC, 2Center for Environmental Medicine and Lung Biology, SYMPOSIUM SESSION: THE ROLE OF MAP KINASES IN University of North Carolina, Chapel Hill, NC and METAL TOXICITY 3Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC. Sponsor: A. Villalobos. Chairperson(s): Alice Villalobos, University of Rochester, Rochester, NY and Aaron Barchowsky, University of Pittsburgh, Graduate School of #1514 11:25 JNK ACTIVATION BY CHROMIUM IN Public Health, Pittsburgh, PA. THE LUNG. A. Barchowsky. Department of Environmental and Occupational Health, University Endorsed by: of Pittsburgh Graduate School of Public Health, Inhalation SS Pittsburgh, PA. Mechanisms SS Metals SS* Wednesday, March 8 Mitogen-activated protein kinases (MAPKs) may mediate the cytotoxic 9:00 AM to 12:00 NOON responses and cytoprotective mechanisms elicited by metals, such as Zn, Room 15A Cd, Cr, and As. The session will open with a review of the common and unique biochemical properties of MAPK family members, ERK1/2, ERK5, WORKSHOP SESSION: ADVANCED TECHNOLOGIES JNKs, and p38 proteins, activation of each MAPK cascade by selective AND APPROACHES FOR QUANTITATIVE BIOLOGICAL stimuli, and the respective down stream targets in the context of their MONITORING AND MODELING FOR CHEMICAL EXPOSURES physiological function. A common cellular response to exposure to various Chairperson(s): Charles Timchalk, Pacific Northwest National Laboratory, metals is an altered redox state. The second talk will address direct activa- Richland, WA and Karla Thrall, Battelle Pacific Northwest Laboratories, tion of MAPKs by oxidants, such as hydrogen peroxide, and electrophiles, Richland, WA. such as 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxidation. A highlighted example of MAPKs as mediators of cytoprotective mecha- Endorsed by: nisms recruited in response to oxidative stress will be HNE-induction of Biological Modeling SS g-glutamyl transpeptidase via ERK1/2 and p38 and of glutamate-cysteine Occupational and Public Health SS ligase via JNK, two responses critical to adaptive increases in GSH. The third talk will address MAPKs as mediators of cytotoxic responses trig- There is a need to develop sensitive and novel approaches that can be used gered specifically by metal-induced oxidative stress. For example, Cr(VI) for biological monitoring of both occupational and environmental expo- at toxic concentrations, via ERK1/2 and p38, upregulates p21 and cdc2 and sures to a broad-range of chemical agents, and to rapidly determine the causes degradation of cdc25C, leading to growth arrest at G2/M. The last potential implications of these exposures to human health. This symposium WEDNESDAY up-to-date information at www.toxicology.org 181 -
.
Toxicology and Toxicology 1 . 2 Annual Meeting Annual th SOT's 45 SOT's and C. J. Gordon and C. J. 1
Neurotoxicology Division, U.S. EPA, Research Research EPA, U.S. Division, Neurotoxicology
Triangle Park, NC. Park, Triangle THERMOREGULATORY INTEGRATED Gordon. C. J. TOXICANTS. TO RESPONSES Research EPA, U.S. Division, Neurotoxicology Hotchkiss NC. Sponsor: J. Park, Triangle 2 BODY TEMPERATURE CHANGES TEMPERATURE BODY STUDIES: INHALATION IN RODENT OR EFFECT ADVERSE OF INDICATOR RESPONSE? ADAPTIVE RODENT-SPECIFIC Section of Inhalation, Bayer Toxicology . Pauluhn J. Germany. Wuppertal, AG, Healthcare THERMOREGULATION AND ITS THERMOREGULATION ASSESSMENT. TOXICITY INFLUENCE ON Research and Consulting (TERC), Environmental MI and Midland, Chemical Company, The Dow J. A. Hotchkiss J.
(Continued) Annual Annual th Inhalation SS Risk Assessment SS* Risk Neurotoxicology SS Neurotoxicology Carcinogenesis SS Carcinogenesis Temperature Temperature is a fundamental factor influencing all aspects of biological systems. Perhaps because of its simplicity and ubiquitous nature, changes in body temperature are often overlooked, or minimized, when assessing the toxicity of chemicals, air pollutants, toxins and pharmacologic agents. Rodents in particular can respond regulatedto acutereduction xenobioticin core exposure body with temperature have a a (hypothermia)major impact which on can physiological and This acute response biochemical is beneficialorganism. generally to the animal because processes of the supportive measures to prevent the dropdecrease in survival.core bodyThe temperatureimpact canoflimited to endpoints. acute Micronucleus toxicologic formation is routinely toxicant-induced hypothermia is used notto establish the potential mutagenicity of hypothermia a alone test can increase material. micronucleus formation,However, confounding the interpretation of the mutagenic activity attributed directly to the from toxicant that of the toxicant-induced adaptive hypothermic hypothermiaresponse. While is the predominant thermoregulatory exposureresponse in to rodents,toxicant- hyperthermia is a following frequentacute observationexposure to in a humans variety notof respondtoxicants. similarly Because to humansexposure to do toxic agents be confounded, data increasing the extrapolation uncertainty can of the risk assessment process. Given the complexity and divergencetoxicity data ofderived from theseexposures physiologicin rodents should the responses, context be of considered any chemical-induced in effects on thermoregulation in order to improve predictions of potential human This toxicity. workshop should be of interest to experimental toxicologists in with individuals involved pharmaceutical alldevelopment, human risk assess disciplines, as well as #1522 9:05 9:00 AM to 12:00 NOON 9:00 Room 6E AND ITS THERMOREGULATION SESSION: WORKSHOP ASSESSMENT TOXICITY INFLUENCE ON MI Midland, Chemical Company, The Dow Hotchkiss, Chairperson(s): Jon Research Agency, Protection Environmental U.S. and Christopher Gordon, NC. Park, Triangle by: Endorsed #1523 9:40 ment, and product regulation and registration. ment, and product regulation #1521 9:00 Wednesday, March 8 March Wednesday, 45 182 - - Meeting & ToxExpo & Meeting C. C. K. D. K. D. . Pacific Karla and T. , K. Ahn, S. , K. Hammock D. B. C. Timchalk C. , W. Yantasee, G. Liu and Y. Y. G. Liu and Yantasee, W. , Timchalk C. . . J. Gee, A. Gonzalez, H. Kim, M. Koivunen, M. M. Koivunen, A. Gonzalez, H. Kim, Gee, J. Stoutamire. and D. E. Park Nichkova-Dosev, CA. of Californai, Davis, University A USING BIOLOGICAL MONITORING OF EXHALED BREATH COMBINATION AND PBPK MODELING. ANALYSIS Timchalk Timchalk SCREENING HAZARDOUS INDUSTRIAL AND TOXICITY CHEMICALS FOR and S. Kailasam. K. R. Rogers GENOTOXICITY. Sponsor: NV. Vegas, Las EPA, U.S. NERL-LV, EXPOSURES. OF IMMUNOASSAYS APPLICATION AND ENVIRONMENTAL IN HUMAN MONITORING. Northwest National Laboratory, Richland, WA. Richland, National Laboratory, Northwest A COMPREHENSIVE BIOMONITORING TO ASSESS EXPOSURES TO APPROACH TOXICANT NONPERSISTENT ORGANIC GENERAL EXPOSURE TO APPLICATION B. D. EFFECTS STUDIES. AND HEALTH Atlanta, GA. Sponsor: NCEH/DLS, CDC, Barr. Lin. Battelle, Pacific Northwest Division, Richland, Lin. Battelle, Pacific Richland, Division, Northwest WA. . Battelle, Pacific Division, Thrall Northwest WA. Richland, BIOMONITORING NON-INVASIVE DOSIMETRY DETERMINE TO APPROACHES CHEMICAL AND RISK FOLLOWING AND OF LEAD ANALYSIS EXPOSURE: INSECTICIDE IN ORGANOPHOSPHATE SALIVA. ADVANCED TECHNOLOGIES AND TECHNOLOGIES ADVANCED FOR QUANTITATIVE APPROACHES FOR CHEMICAL BIOMONITORING 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1519 10:55 #1517 9:45 #1518 10:20 #1516 9:10 will highlight technology that focuses on the application of bio-analytical chemistry for assessing lowdevelopment oflevel sensitive, chemicalselective, rapid, andexposure, cost-effective toxicitysensors coupledscreening,for biomonitoring,to theand development These platforms.approaches can be applied biomarkers in ofto identify novel field deployable animal experimental model systems and in humans using a range of readily through the application of advanced matrices. biological Finally, obtainable computational modeling it may be possibledosimetry. to The quantitativelyfirst determinespeaker will chemical exposures in biomarkers samples biological of obtained low-level focus on approaches for from quantifying epidemiology studies using mass spectrometry isotope dilution. The second and third speakers will highlight ongoing research focused on the development of toxicity cost-effective screening methods, and the applica #1520 11:30
tion of immunoassay based biosensor platforms final for two biomonitoring.speakers The will highlight the potentialresolution analytical applicationapproaches and of sensor these technologies highto assess chem ical exposures in real-time through the direct analysis or of saliva for exhaled a breath range of agents including organic insecticides, and solvents, the heavy application of metals, based physiologically pharmacokinetic models to assess total exposure and internal target important insight on the value presentations in this symposium will provide tissue dosimetry. The of integrating quantitative sensor technology withmonitoring approaches traditionalto advance biologicalour capabilities for chemical exposure monitoring and modeling. biological #1515 9:00 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1524 10:15 THERMOREGULATION: A KEY VARIABLE #1531 10:20 NALTREXONE HYDROCHLORIDE: A FOR INTERPRETING RESULTS FROM THE CARDIOVASCULAR TELEMETRY STUDY MOUSE MICRONUCLEUS TEST. P. J. Spencer, IN THE UNRESTRAINED NAÏVE MALE J. M. Grundy, J. M. Waechter and B. Gollapudi. CYNOMOLGUS MONKEY. J. C. Tigner1, H. Toxicology & Environmental Research and Penton2, H. Ibrahim1 and N. Leblond2. 1Purdue Consulting, The Dow Chemical Company, Midland, Pharma, Ardsley, NY and 2Toxicology, Charles River MI. Laboratories Preclinical Montréal, Senneville, QC, Canada. #1525 10:50 TEMPERATURE AND NEUROTOXICITY - LESSONS FROM THE AMPHETAMINES. D. #1532 10:40 EVALUATION OF THE USE OF TIME- B. Miller. Toxicology & Molecular Biology Branch, SYNCHRONIZED VIDEO RECORDING IN CDC-NIOSH, Morgantown, WV. DRUG SAFETY ASSESSMENT: APPLICATION TO QT PROLONGATION STUDIES. E. L. #1526 11:25 IMPACT OF THERMOREGULATION ON Bijaoui, V. Benadava, P. Hua, D. Dreptate, S. PHARMACOKINETIC PARAMETERS AND Lascu, Y. Del Sindaco, V. Ripoll, O. Cochelin, M. IMPLICATIONS FOR HUMAN TOXICITY Lemanissier, J. Darche, H. Moutot and P. Zitoun. ASSESSMENT. P. M. Hinderliter and R. A. Corley. NOTOCORD Systems, Croissy sur Seine, France. Biological Monitoring and Modeling, Pacific Sponsor: L. Kinter. Northwest National Laboratory, Richland, WA. #1533 11:00 APPLICATION OF A NON-INVASIVE TELEMETRY SYSTEM FOR Wednesday, March 8 ELECTROCARDIOGRAM ASSESSMENT IN 9:00 AM to 12:00 NOON A DOG TOXICOLOGY STUDY. J. Schofield, Room 2 N. McMahon, M. Coulson, T. Hammond and J. Valentin. Safety Assessment, AstraZeneca R&D, PLATFORM SESSION: CARDIOVASCULAR SAFETY Macclesfield, United Kingdom. ASSESSMENT #1534 11:20 ASSESSMENT OF THE IMPACT OF Chairperson(s): Betty Ann Petterson, Pfizer Global Research & CARDIOTOXICITY DIAGNOSIS BY Development, Groton, CT and Lewis Kinter, AstraZeneca Pharmaceuticals TROPONIN AND GENOMICS MEASURES. LP, Wilmington, DE. R. Dunn, P. Nordone, S. Thukral, L. Healy, E. #1527 9:00 THE RAT H9C2 EMBRYONIC VENTRICULAR Galambos, P. Sabitsana, A. Fosdick, J. Urgino, MYOCYTE CELL LINE: AN IN VITRO R. Hu, M. Cosenza and C. Afshari. Comparative MODEL FOR EXAMINING STRIATED Biology and Safety Sciences, Amgen, Thousand MUSCLE TOXICITY. G. H. Searfoss, B. W. Oaks, CA. Halstead, R. A. Jolly, T. K. Baker, H. Gao, M. A. Higgins and T. P. Ryan. Investigative Toxicology, #1535 11:40 ZEBRAFISH: A PREDICTIVE MODEL FOR Lilly Research laboratories, Greenfield, IN. Sponsor: ASSESSING CARDIOTOXICITY OF DRUG C. Thomas. CANDIDATES. C. Ton, C. Willett, N. Roy, Y. Lin, C. Parng and P. McGrath. Phylonix Pharmaceuticals, #1528 9:20 INTERPRETATION OF QT INTERVAL USING Inc., Cambridge, MA. Sponsor: L. Costa. HEART RATE CORRECTION FORMULA IN PRE-CLINICAL TOXICOLOGY STUDIES. Wednesday, March 8 D. Dandekar, L. P. Sheets, S. Ensley, K. Willard, 9:00 AM to 12:00 NOON J. Applegate, D. Phipps, P. McKinney, J. Stroup, Room 1B S. Fontana and W. Bomann. Bayer CropScience, Stilwell, KS, KS. PLATFORM SESSION: DIOXINS, PCBS AND PBDES #1529 9:40 USE OF A FAILING RABBIT HEART AS A MODEL TO PREDICT TORSADOGENICITY. Chairperson(s): Linda Birnbaum, U.S. EPA, Research Triangle Park, NC A. Kijtawornrat1, Y. Nishijima1, 2, B. Roche2, and Dennis Paustenbach, ChemRisk Inc., San Francisco, CA. B. Keene2, 3 and R. Hamlin1, 2. 1Department of #1536 9:00 DIOXIN AND DIABETES: DOES THE Veterinary Biosciences, The Ohio State University, CURRENT WEIGHT OF EVIDENCE Columbus, OH, 2QTest Labs, Inc., Columbus, OH DEMONSTRATE A RELATIONSHIP? M. and 3Department of Veterinary Clinical Sciences, Gough3, D. J. Paustenbach4, B. D. Kerger1, H. North Carolina State University, Raleigh, NC. Leung2, P. Scott6 and M. Harris5. 1HSRI, Inc., Sponsor: M. Hejtmancik. Tallahassee, FL, 2Consultant, Danbury, CT, 3Consultant, Bethesda, MD, 4ChemRisk, San #1530 10:00 RELIABILITY OF TELEMETRY IN Francisco, CA, 5ChemRisk, Houston, TX and COMMON MARMOSETS FOR EVALUATION 6ChemRisk, Pittsburgh, PA. OF DRUG-INDUCED QT INTERVAL PROLONGATION. T. Hara, S. Sone, N. #1537 9:20 ALTERATION IN CARCINOGENIC Shishido, S. Kuramoto, K. Nakano, H. Onodera, POTENCY OF PCB126 BY PCB153 M. Tabo, K. Kimura and K. Kobayashi. CHUGAI FOLLOWING CHRONIC EXPOSURE IN Pharmaceutical Co., Ltd., Kamakura shi, Kanagawa, FEMALE RATS. N. J. Walker1, M. E. Wyde1, M. Japan. Sponsor: T. Sugimoto. Easterling2, A. Nyska1, C. R. Portier1 and J. R. Bucher1. 1Environmental Toxicology Program, NIEHS, Research Triangle Park, NC and 2Constella
Group, Research Triangle Park, NC. WEDNESDAY up-to-date information at www.toxicology.org 183 , 1
, V. S. , V. , 2 1 , H. 2, 6 1 Amgen, 4
α E. Blomme,
Pediatrics, Pediatrics, 6 , G. Lee A. J. Schecter A. J. 2 Environmental Environmental Reproductive Reproductive R. Cantor 1 2 , . 5 3 Annual Meeting Annual , C. R. Lambright , D. Shih , D. th 2 1 Human Genetics, UCLA, Molecular Toxicology, Toxicology, Molecular 2 1 Health Canada, Ottawa, Health Canada, Ottawa, 3 . 1 NCSU/U.S. EPA Cooperative Cooperative EPA NCSU/U.S. Veterinary Biosciences, Biosciences, Veterinary 1 , K. Carnes 5 5 J. Ryan and J. . Eurofins ERGO Laboratory, Eurofins ERGO Laboratory, 1 2 2 , J. Furr , J. . Experimental Radiation USC, Los Angeles, CA, USC, Los , X. Liao 3 3 1, 2 SOT's 45 SOT's R. Hess , 4 , K. Tung , K. 2 , G. Shetty, G. A. Shuttlesworth A. Shuttlesworth G. , G. Shetty, K. Porter and M. Collins and L. Gray 2 2 , H. Allayee , H. 1
Hamburg, Germany and Germany Hamburg, Training Agreement CT826512010, North Carolina Training Raleigh, NC and State University, K. L. Howdeshell UCLA, Los Angeles, CA, UCLA, Los IN DIBROMOACETIC ACID-INDUCED ACID-INDUCED IN DIBROMOACETIC IN RATS. TOXICITY TESTICULAR Thousand Oaks, CA, TESTES. and M. L. Meistrich Chen DI(N-BUTYL) PHTHALATE AND PHTHALATE DI(N-BUTYL) IN DIETHYLHEXYL PHTHALATE SEXUAL ALTER COMBINATION A CUMULATIVE IN DIFFERENTIATION OF DEPRESSED A RESULT AS MANNER AND PRODUCTION TESTOSTERONE FETAL INSL3 GENE EXPRESSION IN MALE RATS. University of Illinois, Urbana, IL and University ON, Canada. ON, R. Ciurlionis, I. Milicic, T. Carr, K. Whitney, T. T. Whitney, K. Carr, T. R. Ciurlionis, I. Milicic, and M. Strakhova. Waring J. Baranowski, J. Miller, IL. Abbott Park, Abbott Labs, ENHANCES DIRECTLY ESTROGEN RADIATION-INDUCED FROM RECOVERY ARREST IN RAT SPERMATOGONIAL Anderson Cancer M.D. of.T. Universtiy Oncology, TX. Houston, Center, CALCINEURIN, TO AN INHIBITOR FK506, TESTICULAR DAMAGE AMELIORATES CADMIUM IN MICE. L. MartinTO DUE Sciences, University of Texas School of Public School of Public Texas of Sciences, University TX, Health, Dallas, J. Lusis J. UCLA, Los Angeles, CA. UCLA, Los Wilson POLYBROMINATED DIPHENYL ETHERS POLYBROMINATED AND FETAL ADULT THE USA: (PBDES) IN FOOD LEVELS, TISSUE LEVELS, HUMAN AND AND BLOOD PARTITIONING, MILK SAMPLING. ENVIRONMENTAL O. Paepke O. D. Hovland D. Toxicology Division, NHEERL, ORD, U.S. EPA, EPA, U.S. ORD, NHEERL, Division, Toxicology NC. Park, Triangle Research P450C17 OF CYTOCHROME ROLE Los Angeles, CA, Los
(Continued) Annual Annual th 9:00 AM to 12:00 NOON 9:00 Room 8 AND FEMALE REPRODUCTIVE MALE SESSION: PLATFORM SYSTEM AZ and Tucson, Arizona, of Chairperson(s): Kathila Rajapaksa, University CA. Irvine, Irvine, of California University Ulrike Luderer, #1545 9:00 Wednesday, March 8 March Wednesday, #1547 9:40 #1548 10:00 #1544 11:40 #1546 9:20 45 184 Meeting & ToxExpo & Meeting . , 3 2 1,
and 3 M. , K. Aichi 2 , 3 , A. , 2 F. , F. and 1 2 N. and N. 2 1 M. E. , B. Zhao , B.
1 Graduate 4 G. and G. , S. Goodwin P-DIOXIN- 3 , A. Koganti , Nat’l Institute for Nat’l 1 1 Constella Group, M. Denison , C. F. Vogel , C. F. 3 and S. B. Hamilton and S. B. J. Silkworth , J. . , L. M. Fomby 3 1 , 1 4 1 J. R. Bucher , J. 3 1, 2 In Vitro Technologies, Technologies, Vitro In , S. Nijmeijer 2 1 L. Robertson University of Stockholm, University University of California University 3 Feinstone Center for Genomic Feinstone 2 3 T. R. Sutter , T. Corporate Environmental Corporate Environmental 1 3 K. Illouz IRAS, University of Utrecht, IRAS, University , M. Zhao J. Silkworth J. 1 1 Global Research Center, General Global Research Center, . In Vitro Technologies, Inc., Technologies, Vitro In , M. Vallant , M. 1 1 2 1 . 4 , H. Nishimura 1 T. Sanderson , T. , M. Easterling C. Tohyama and C. 3 NIEHS, Research Triangle Park, NC, Park, Triangle NIEHS, Research 2 2 1 . 1 , A. Possolo , 2 A. Nyska , A. Possolo , , 1 1 Corporate Environmental Programs, General Programs, Corporate Environmental 4 Global Research Center, General Electric, General Electric, Global Research Center, J. Yonemoto , J. Health Sciences, Center for Environmental Battelle, Columbus, OH and Research, University of Memphis, Memphis, TN of Memphis, Memphis, Research, University School of Medicine, University of Tokyo, Tokyo, Tokyo, Tokyo, of School of Medicine, University N. Nishimura N. INDCUD HYDRONEPHROSIS. A. Bergman J. Walker J. A. K. Peters SYSTEMS. Utrecht, Netherlands, R. Garcia Boy, LINES. R. Garcia Boy, S. B. Hamilton S. B. Illouz 1 NY, Niskayuna, Baltimore, MD and M. van den Berg and University of California, Davis, Davis, CA, Davis, of California, Davis, University Japan. HUMAN OF CHARACTERIZATION TCDD, TO RESPONSES HEPATOCYTE 1254 USING DNA AROCLOR AND PCB 126, MICROARRAYS. THE DEVELOPING MOUSE KIDNEY THE DEVELOPING MOUSE 7, 3, OF 2, A POSSIBLE CAUSE AS 8-TETRACHLORODIBENZO- 2 2 RELATIVE CARCINOGENIC POTENCY CARCINOGENIC POTENCY RELATIVE AND PECDF IN DERMALLY OF PCB 126 MICE. TG.AC EXPOSED FEMALE Hejtmancik 2 Environment Studies, Tsukuba, Ibaraki, Japan, Studies, Environment Matsumura Inc., Baltimore, MD, Inc., Baltimore, MD, Electric, Fairfield, CT. Electric, Fairfield, APPROPRIATE DEVELOPMENT OF MORE BY VALUES TEF RISK AND DIOXIN PCB ANIMAL AND USING FRESH HUMAN HEPATOCYTES. CT. General Electric, Fairfield, Programs, EFEECTS OF POLYBROMINATED CELL DIPHENYL ETHERS ON PROSTATE Electric, Niskayuna, NY, NY, Electric, Niskayuna, Health, . Occupational and Environmental Ludewig IA. City, Iowa of Iowa, University DIPHENYL ETHERS POLYBROMINATED TCDD INDUCED ANTAGONIZE (PBDES) VITRO IN VARIOUS IN ACTIVITY CYP1A1 Wyde Stockholm, Sweden. Davis, Davis, CA and Davis, Davis, Research Triangle Park, NC. Park, Triangle Research IN OF SALT-HANDLING DISRUPTION Koganti Mizuho University, Toyota, Japan and Toyota, Mizuho University, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1540 10:20
#1538 9:40 Program Description Description Program #1541 10:40 #1542 11:00 #1543 11:20 #1539 10:00
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1549 10:20 OPPOSING EFFECTS OF GLUTATHIONE #1555 9:20 RELATIONSHIP BETWEEN PULMONARY (GSH) DEPLETION AND FOLLICLE EXPOSURE TO MULTIPLE DOSES OF STIMULATING HORMONE (FSH) ON SINGLE WALL CARBON NANOTUBES AND APOPTOSIS AND REACTIVE OXYGEN ATHEROSCLEROSIS IN APOE-/- MOUSE SPECIES (ROS) IN CULTURED ANTRAL MODEL. Z. J. Li, R. Chapman, T. Hulderman, FOLLICLES. M. M. Tsai-Turton1 and Universtiy R. Salmen, A. Shvedova, M. I. Luster and P. P. of. Luderer2, 1. 1Community and Environmental Simeonova. HELD/TMBB, NIOSH, Morgantown, Medicine, University of California, Irvine, CA and WV. 2Medicine, University of California, Irvine, CA. #1556 9:40 SINGLE WALL CARBON NANOTUBES #1550 10:40 OVOTOXICITY INDUCED BY 7, 12- INDUCE OXIDATIVE STRESS, ACUTE DIMETHYLBENZ[A]ANTHRACENE IN INFLAMMATION, AND PROGRESSIVE A B6C3F1 MOUSE OVARIAN CULTURE PULMONARY FIBROSIS. E. Kisin1, A. R. SYSTEM. K. Rajapaksa1, I. Sipes2 and P. B. Hoyer1. Murray2, V. Castranova1, V. E. Kagan3 and A. A. 1Physiology, University of Arizona, Tucson, AZ and Shvedova1. 1PPRB, NIOSH, Morgantown, WV, 2Pharmacology, University of Arizona, Tucson, AZ. 2WVU, Morgantown, WV and 3University of Pittsburgh, Pittsburgh, PA. #1551 11:00 TEMPORAL RESPONSE OF GENE EXPRESSION TO ACUTE EXPOSURE #1557 10:00 OXIDATIVE INTERACTIONS OF SINGLE TO 17 α-ETHYNYL ESTRADIOL IN THE WALLED CARBON NANOTUBES WITH RAW IMMATURE RAT UTERUS. J. M. Naciff, G. 264.7 MACROPHAGES: ROLE OF IRON. A. J. Overman, S. M. Torontali, G. J. Carr, L. M. A. Shvedova1, A. I. Potapovich2, A. N. Osipov2, Foertsch, Z. S. Khambatta, J. P. Tiesman and G. P. Y. Y. Tyurina2, E. Kisin1, D. Schwegler-Berry1, R. Daston. Central Product Safety, Procter & Gamble Mercer1, V. Castranova1 and V. E. Kagan2. 1PPRB, Company, Cincinnati, OH. NIOSH, Morgantown, WV and 2University of Pittsburgh, Pittsburgh, PA. #1552 11:20 CULTURED MAMMARY EPITHELIAL CELLS DISPLAY IMPAIRED #1558 10:20 THE CYTOTOXICITY AND CYTOTOXIC DIFFERENTIATION AND ENHANCED MECHANISMS OF CERIUM OXIDE PROLIFERATION WHEN EXPOSED TO NANOPARTICLES AGAINST LUNG CANCER THE ARYL HYDROCARBON RECEPTOR CELLS. Y. Ma1, W. Lin1, Y. Huang2, X. Zhou3 (AHR) AGONIST TCDD. B. Lawrence1, 2 and and P. Nam1. 1Department of Chemistry and B. A. Vorderstrasse1, 2. 1Pharmaceutical Sciences, Environmental Research Center for Emerging Washington State University, Pullman, WA and Contaminants, University of Missouri-Rolla, 2Center for Reproductive Biology, Washington State Rolla, MO, 2Department of Biological Sciences University, Pullman, WA. and Environmental Research Center for Emerging Contaminants, University of Missouri-Rolla, Rolla, #1553 11:40 POLYBROMINATED DIPHENYL ETHERS MO and 3Pacific Northwest National Laboratory, STIMULATE THE RELEASE OF PRO- Ricjland, WA. INFLAMMATORY CYTOKINES FROM TERM HUMAN GESTATIONAL MEMBRANES. #1559 10:40 ASSESSMENT OF MANGANESE K. A. Brant, N. W. Thiex and R. Loch Caruso. NANOPARTICLE (MN-40NM) IN PC12 CELLS. Environmental Health Sciences, University of A. Javorina1, 3, H. Duhart2, S. F. Ali2, J. J. Schlager1 Michigan, Ann Arbor, MI. and S. M. Hussain1. 1Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, Wednesday, March 8 2Division of Neurotoxicology, National Center for 9:00 AM to 12:00 NOON Toxicological Research, Jefferson, AR and 3Oak Room 5A Ridge Institute for Science and Education, Oak Ridge, TN. PLATFORM SESSION: NANOPARTICLE-INDUCED TOXICITY #1560 11:00 EFFECTS OF NANOPARTICLES ON IMMUNE Chairperson(s): Lung Chi Chen, NYU School of Medicine, Tuxedo, NY. RESPONSE TO PROTEIN ANTIGEN. V. J. #1554 9:00 NANO-TIO2 ANATASE PARTICLES VS. Tomazic-Jezic, T. H. Umbreit and M. E. Stratmeyer. RUTILE PARTICLES: A CYTOTOXICITY OSEL, USFDA/CDRH, Rockville, MD. AND INFLAMMATORY RESPONSE STUDY WITH HUMAN DERMAL FIBROBLASTS #1561 11:20 IMPACT OF NANO- TO MICRON-SIZED AND HUMAN LUNG EPITHELIAL CELLS. C. PARTICLE CHARACTERISTICS ON IN 1 2 1 VITRO ALUMINUM PARTICLE TOXICITY. M. Sayes , D. B. Warheit , K. D. Ausman and V. L. 1, 2 3 3 1 1 M. Palazuelos , G. Erdos , D. A. Moraga , M. Colvin . Chemistry, Rice University, Houston, TX 3 2, 4 2 and 2DuPont Haskell lab, DuPont, Newark, DE. Popp , B. M. Moudgil and K. W. Powers . 1Department of Chemical Engineering, University of Florida, Gainesville, FL, 2Particle Engineering Research Center, University of Florida, Gainesville, FL, 3Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL and 4Department of Materials Science and Engineering, University of Florida, Gainesville, FL. Sponsor: S.
Roberts. WEDNESDAY up-to-date information at www.toxicology.org 185 . , . 3 1 1
1 SC 2 . 1 M.
IN School
1 . National , J. J. J. , J. Fort Fort 2 2 2 1 . 2 Vet. Med.: Med.: Vet. 2 Student , G. D. , G. D. 3 and S. Bursian 1 , K. R. Cooper 2 and J. E. Tietge E. and J. 2 XENOPUS 3 Center for . 2 Annual Meeting Annual , R. E. Gutjahr-Gobell 1 th Department of Animal Department of 3 and G. E. Zaroogian , K. R. Thoemke , K. R. 1 D. S. Barber and D. 1 1 J. A. Weeks A. and J. , B. Lasley , B. 2 1 , T. Ledoux T. , 1 Reproductive Toxicology Toxicology Reproductive 2 , R. L. Rogers Joint Graduate Program in Joint Graduate Program 1 1 , M. E. Bugge 3 . 3 L. J. Mills L. J. School of Public Health, UMDNJ School of Public 3 SOT's 45 SOT's E. J. Ray E. J. , S. J. Degitz , S. J. 1 , S. Jayaraman D. J. Fort J. D. 2 P. D. Guiney D. , P. 1 M. Gutierrez , L. M. Korte 1 NHEERL, MED., U.S. EPA, Duluth, MN, Duluth, MN, EPA, U.S. NHEERL, MED., Division of Science, Research and Technology, New New Technology, of Science, Research and Division Atlantic Ecology Division, U.S. EPA, NHEERL, EPA, U.S. Division, Atlantic Ecology Microbiol. and Immunol., Med.: Pathol., Vet. Sciences., Michigan State University, East Lansing, State University, Sciences., Michigan Division, U.S. EPA, NHEERL, Research Triangle Triangle NHEERL, Research EPA, U.S. Division, NC. Park, OIL FUEL FROM CHEMICAL STRESS HYPERTROPHY ADRENAL CAUSES GLUCOCORTICOID WITHOUT CHANGING Environmental Laboratories, Stillwater, OK and Laboratories, Stillwater, Environmental Jersey Department of Environmental Protection, DepartmentJersey of Environmental NJ and Trenton, Narragansett, RI and CA, of California, Davis, University W. Hornung W. AND INHIBITION BY METHIMAZOLE. Korte 1 Research Council, Duluth, MN and W. Benson Breeze, FL. Sponsor: W. of Florida, Gainesville, FL and Florida, Gainesville, FL. VESICLE INHIBITION OF GERMINAL IN XENOPUS OOCYTES BREAKDOWN ETHERS. Anderson and M. G. Robson 2 Johnson Medical School, Piscataway, Wood - Robert NJ. THYROID DOSE-DEPENDENT AND TIME HORMONE RELEASE FROM EFFECTS OF ATRAZINE ON BRAIN AND ON BRAIN ATRAZINE EFFECTS OF AND ACTIVITY AROMATASE GONAD A IN PARAMETERS REPRODUCTIVE MARINE FISH. S. C. Laws 1 C. Mohr RELEASE. F. 1 MI. EFFECTS ON AGONISTS ANDROGEN PLASMA ESTROGEN-RESPONSIVE THE PEPTIDE EXPRESSION IN A. K. Hemmer, M. J. SHEEPSHEAD MINNOW. L. L. Dobbins and C. Watts, S. Harris, J. Salinas, P. Gulf NHEERL, GED, ORD, EPA, U.S. Walker. C. THE EFFECTS OF P’, P’-DDE ON THE EFFECTS OF P’, THE SUCCESS OF REPRODUCTIVE (PIMEPHALES MINNOW FATHEAD PROMELAS). of University Toxicology, and Human Environmental BY POLYBROMINATED DIPHENYL BY POLYBROMINATED VITRO Services Contractor, U.S. EPA, Duluth, MN. EPA, U.S. Services Contractor, of Natural Resources and Environment, University University of Natural Resources and Environment, THYROID GLAND CULTURES IN RESPONSE GLAND CULTURES THYROID HORMONE STIMULATING THYROID TO Johnson & Son, Racine, WI. Johnson & Son, Racine, ATRAZINE BY ENDOCRINE DISRUPTION ENVIRONMENTAL AND OTHER NEW JERSEY ON NATIVE CONTAMINANTS FROGS. Toxicology, Rutgers University, Piscataway, NJ, NJ, Piscataway, Rutgers University, Toxicology, Pop. Health and Reproduction, University of Health and Reproduction, University Pop. CA and California, Davis,
(Continued) Annual Annual th #1567 #1570 #1572 #1566 #1568 #1569 #1571 45 186 , 1 Meeting & ToxExpo & Meeting , . 1 1 , 4 . , S. 1 1 , J. , J. 2 U.S. U.S. , E. F. , E. F. S. 1 1 , A. L. , 1 , . 2 1 Center for 4
, D. Bauer , D. 1 , K. M. Jensen , B. Chang , B. 1 3 , P. B. Key B. , P. 1 . , S. Santra , J. R. Varshavsky R. , J. Materials Science 1 1 C. D. Vulpe and C. D. 1 W. S. Baldwin and W. 3 1 , E. J. Durhan , E. J. Chemistry, University University Chemistry, . 1 3 1 D. L. Villeneuve L. . D. and G. T. Ankley T. and G. 3 , L. S. Blake , J. Steevens , J. 1 2 J. A. Roling J. , A. V. Loguinov V. A. , 1 L. J. Bain , L. J. 3 , E. J. Perkins , E. J. 4 Analytical Services Inc., Vicksburg, Vicksburg, Services Inc., Analytical 2 , X. Guan 2 , E. A. Makynen , E. 1 Center for Coastal Environmental Health, Health, Center for Coastal Environmental 2 , K. J. Greene , K. J. , A. L. Miracle , Pacific Northwest National Laboratory, Pacific National Laboratory, Northwest and B. M. Moudgil and B. 2 1 3 3 , P. S. Holman , P. HBOI, Florida Atlantic University, Ft. Pierce, Atlantic University, HBOI, Florida Environmental Laboratory, Engineer Laboratory, Environmental 1 2 3
Nutri. Sciences. and Toxicology, UC Berkeley, UC Berkeley, Toxicology, Nutri. Sciences. and Biological Sciences, University of Texas-El Paso, El Paso, Texas-El of Sciences, University Biological Nanoscience Technology Center, Department Center, Technology Nanoscience Toxicology and Human Center for Environmental Genomics and Bioinformatics, Indiana University, Genomics and Bioinformatics, Indiana University, Bloomington, IN. FOR ASSAYS RT-PCR QUANTITATIVE AND AND CYP11A STAR MINNOW FATHEAD THEIR ON EFFECTS OF KETOCONAZOLE and Engineering and Particle Research Engineering of Florida, Gainesville, FL, University Center, Gardea-Torresdey IN VIVO EXPRESSION IN Orlando Linnum FL and MS, CHEMICALS. H. C. Poynton Chan 1 CA, Berkeley, SUPERFUND SITE. 1 MUMMICHOG CDNA ARRAYS AS A AS ARRAYS MUMMICHOG CDNA CHROMIUM FOR MONITORING TOOL AN ESTUARINE AT REMEDIATION TX, Paso, K. Colbourne J. 3 Florida, Gainesville, FL. TOXICITY OF TOXICITY VITRO THE IN ASSESSING AMORPHOUS SILICA FUNCTIONALIZED Dutta D. NANOPARTICLES. Roberts 2 of Chemistry Science Center, and Biomolecular Central Florida, Orlando, FL and of University of Medicine, University Veterinary of and College M. D. Kahl M. D. Duluth, Division, Mid-Continent Ecology EPA MN, Mata Sponsor: J. WA. Richland, NOAA, Charleston, SC and Charleston, NOAA, Research and Development Center, U.S. Army Army U.S. Center, Research and Development MS and Vicksburg, Corps of Engineers, of Texas-El Paso, El Paso, TX. El Paso, Paso, Texas-El of ECOTOXICOGENOMICS MAGNA DAPHNIA EXPRESSION PROFILES REVEALS UNIQUE RELATED AND ORDNANCE FOR METALS A. Kennedy 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1565 9:00 AM–10:30 AM AM–10:30 Attended: 9:00 #1563 9:00 AM to 12:00 NOON 9:00 NY. Jamaica, University, St. Johns Trombetta, Chairperson(s): Louis AM–12:00 NOON 9:00 Displayed: Exhibit Hall ECOTOXICOLOGY POSTER SESSION: Wednesday, March 8 March Wednesday,
#1562 11:40 Program Description Description Program #1564
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1573 THE PITUITARY RESPONSE TO CHEMICAL #1581 EVALUATION OF BROMINATED FLAME THYROID AXIS DISRUPTION IN X. LAEVIS. RETARDANTS IN RELATIONSHIP TO K. R. Thoemke1, J. J. Korte2, M. W. Hornung2, M. E. BOTTLENOSE DOLPHIN IMMUNITY. J. Bugge3, L. M. Korte3, G. W. Holcombe2, J. E. Tietge2 Stuckey1, T. Romano2, 6, C. Rice3, 6, J. EuDaly6, G. and S. J. Degitz2. 1National Research Council, Mitchum5, G. Bossart4, 6, P. Fair5, 6 and M. Peden- Duluth, MN, 2NHEERL, MED., U.S. EPA, Duluth, Adams6, 2. 1College of Charleston, Charleston, SC, MN and 3Student Services Contractor, U.S. EPA, 2Mystic Aquarium, Mystic, CT, 3Clemson University, Duluth, MN. Clemson, SC, 4Harbor Branch Oceanographic Institute, Ft. Pierce, FL, 5NOS/NOAA, Charleston, #1574 EFFECTS OF P, P’-DDE ON BONE TISSUE SC and 6MUSC, Charleston, SC. IN ADULT MALE COMMON FROGS. P. Lind1, R. Lundberg1, M. Ronn2, C. Hernhag2, A. Leiva #1582 VALIDATION OF AN EUKARYOTIC Presa3, B. M. Jenssen3 and J. Orberg2. 1Division of GENOTOXICITY SCREENING ASSAY FOR Biochemical Toxicology, Institute of Environmental ENVIRONMENTAL MONITORING. A. Knight1, Medicine, Karolinska Institutet, Stockholm, Sweden, P. Cahill1 and R. Walmsley2. 1Gentronix Ltd., 2Department of Environmental Toxicology, Uppsala Manchester, United Kingdom and 2Faculty of Life University, Uppsala, Sweden and 3Department of Sciences, University of Manchester, Manchester, Biology, Norwegian University of Science and United Kingdom. Sponsor: S. Dean. Technology, Trondheim, Norway. #1583 INVESTIGATING ENANTIOMER- #1575 DO EDCS EFFECT BONE TISSUE IN GREAT SPECIFIC EFFECTS OF THE CHIRAL LAKES HERRING GULLS? R. Lundberg1, G. PHARMACEUTICAL POLLUTANTS A. Fox2 and M. P. Lind1. 1Division of Biochemical PROPRANOLOL (β-BLOCKER), Toxicology, Institute of Environmental Medicine, FLUOXETINE (SSRI), AND IBUPROFEN Karolinska Institutet, Stockholm, Sweden and (ANALGESIC) TO MODEL AQUATIC 2National Wildlife Research Centre, Canadian ORGANISMS. J. K. Stanley1, A. J. Ramirez2, M. Wildlife Service, Ottawa, ON, Canada. Mottaleb2, C. K. Chambliss2 and B. W. Brooks3. 1Biology, Baylor University, Waco, TX, 2Chemistry #1576 COMPARATIVE EFFECTS OF CARBOFURAN and Biochemistry, Baylor University, Waco, TX and AND DIAZINON ON TIME OF FLIGHT IN 3Environmental Studies, Baylor University, Waco, PIGEONS (COLUMBA LIvia): POTENTIAL TX. FOR AGROCHEMICAL EFFECTS ON MIGRATION. J. M. Brasel and C. A. Pritsos. #1584 RAPID ENVIRONMENTAL IMPACT Nutrition, University of Nevada, Reno, NV. SCREENING OF REACTIVE NANO-IRON PARTICLES (RNIP) USING DAPHNIA AND #1577 TOXIN BINDING ABILITY OF SOILS FATHEAD MINNOWS. E. Oberdorster1, P. Larkin2 CONSUMED BY PARROTS IN THE PERUviaN and D. Rejeski3. 1Biology, Southern Methodist 1 2 AMAZON. J. F. Taylor , D. Brightsmith , H. University, Dallas, TX, 2EcoArray, Inc., Alachua, 1 1 1 Huebner and T. Phillips . Veterinary Integrative FL and 3Woodrow Wilson Center for International Biosciences, Texas A&M, College Station, TX and Scholars, Washington, DC. 2Biology, Duke University, Durham, NC. #1585 USING BLOOD PLASMA AS A #1578 TOXICOPATHOLOGICAL ANALYSIS OF NONDESTRUCTIVE MEANS FOR THE IMPACT OF SODIUM ARSENATE MONITORING PERSISTENT ORGANIC (NA2HASO4. 7H2O) ON SKIN OF THE POLLUTANTS IN WHITE STURGEON CATFISH CLARIAS BATRACHUS (LINN). A. FROM THE COLUMBIA RIVER BASIN. D. K. Singh, I. Chatterjee and T. K. Banerjee. Zoology, Gundersen1, J. Schleier1, E. Bredeweg1, M. Webb2, Banaras Hindu University, Varanasi, Uttar Pradesh, E. Foster3 and B. Cady4. 1Environmental Science India. Program, Pacific University, Forest Grove, OR, 2 #1579 TRIBUTYLTIN INDUCED NEUROTOXICITY US Fish and Wildlife Service, Bozeman, MT, 3 FOLLOWING CHRONIC EXPOSURE IN THE Department of Environmental Quality, Portland, OR 4 STINGRAY UROLOPHUS JAMAICENSIS and Washington Department of Fish and Wildlife, (YELLOW STINGRAY). J. Dwivedi1 and L. Vancouver, WA. 2, 1 1 D. Trombetta . Biological Sciences, St. John’s #1586 MOVEMENT OF MERCURY FROM 2 University, New York and Pharmaceutical Sciences, CONTAMINATED SOIL INTO AN AQUATIC St. John’s University, Jamaica, NY. FOOD CHAIN. A. C. Nichols, D. A. Steffy and C. #1580 SUBCHRONIC TOXIC EFFECTS AND R. Kohute. Physical and Earth Sciences, Jacksonville ACCUMULATION OF HEXAHYDRO-1, 3, State University, Jacksonville, AL. 5-TRINITRO-1, 3, 5-TRIAZINE (RDX) IN #1587 TRIVOREX: SAFETY AND EFFICACY OF 1 ZEBRAFISH (DANIO RERIO). S. mukhi and A NEUTRALIZER AND ABSORBENT FOR 2 1 R. Patino . Environmental Toxicology, Texas Tech CHEMICAL SPREADING AND TREATMENT 2 University, Lubbock, TX and US Geological Survey OF CHEMICAL WASTES. F. Burgher1, C. Texas Cooperative Fish & Wildlife Research Unit, Godard1, H. Coudouel1, A. H. Hall2 and L. Mathieu1. Texas Tech University, Lubbock, TX. 1Scientific researches, Prevor Laboratory, Paris, France and 2Toxicology, TCMTS, Elk Mountain, WY. WEDNESDAY up-to-date information at www.toxicology.org 187
, 1 , and 1 1 and H. 2 R. J. and J. 2 , M. Bracher 1 , C. Piterski Toxicology, Toxicology, 1 1 M. Blazka . , 2 2 , C. Reyes 1 , G. Mun and Research and 2 Lab. Pharmaceutical Lab. Annual Meeting Annual 1 X. Yan X. th . 1 K. Cater .
D. Bagley , D. 1 and C. Goebel J. W. Harbell W. J. 1 SOT's 45 SOT's Ophthalmology, Emory University Emory University Ophthalmology, 1 . 1 and J. Remon and J. 2 Playtex Products, Inc., Allendale, NJ and Inc., Products, Playtex , D. Ghate , D. The Dial Corporation, Scottsdale, AZ and The Dial Corporation, Scottsdale, 1 1 1 . . 2 , J. Rolle , J. 2 1 De Wever Consulting bvba, Oud-Turnhout, Oud-Turnhout, Consulting bvba, Wever De 2 Consumer Product Testing Co., Fairfield, NJ. Fairfield, Co., Testing Consumer Product MD. IIVS, Gaithersburg, Darmstadt, Germany. AG, WELLA Product Safety, P. Aeby P. EVALUATION OF THE OCULAR IRRITATION THE OCULAR IRRITATION OF EVALUATION THE SLUG OF SHAMPOOS USING POTENCY Adriaens E. TEST. MUCOSAL IRRITATION DETECTION OF EYE IRRITATION A WITH OF HAIR DYES POTENTIAL . Institute for In Vitro Sciences, Inc., Vitro . Institute for In Curren D. MD. Gaithersburg, Edelhauser F. S. Nitka 2 Gent, Belgium Ghent University, Technology, and Belgium. AIR ON MARKETED IMPACT FRAGRANCE ASSAY BY BCOP FRESHENER PRODUCTS AND HISTOLOGY. Harbell 2 RECONSTITUTED HUMAN CORNEAL EPITHELIUM MODEL. C. Faller 2 Gerberick Sponsor: F. A HUMAN CORNEAL EPITHELIAL MODEL FOR EVALUATION CULTURE P. Amenuvor, L. OF OCULAR IRRITATION. Roberts and M. J. K. N. A. Hauber, S. Zeigler, Inc., Walkersville, Bio Science . Cambrex Powers MD. Walkersville, APPLICATION OF HISTOLOGICAL OF HISTOLOGICAL APPLICATION THE BOVINE ENHANCE TO EVALUATION AND PERMEABILITY CORNEAL OPACITY ASSAY. (BCOP) COMPARE TO TECHNIQUE VITRO A NEW IN IN OF SURFACTANTS TOXICITIES THE AND HUMAN CORNEAS. RABBIT ISOLATED G. Holley Cosmital SA (WELLA AG), Marly, Switzerland and Marly, AG), Cosmital SA (WELLA B. De Wever De B. Eye Center, ATlanta, GA and ATlanta, Center, Eye Co., Piscataway, Palmolive Colgate- Development, NJ. THE PRECISION, EVALUATING THE OF AND CORRELATION SENSITIVITY TEST – CHORIOALLANTONIC HEN’S EGG FOR MEMBRANE METHOD (HET-CAM) ASSESSMENT OF EYE IRRITATION THE PERSONAL OF FORMULATED POTENTIAL RINSE-OFF PRODUCTS.
(Continued) Annual Annual th #1598 #1600 #1596 #1599 #1601 #1595 #1597 45 188 , 1 Meeting & ToxExpo & Meeting
, K.
2 E. IN College College . 2 J. and J. Laboratorie 3 2 and H.
, R. L. 1 1 . , R. Babu J. D. Vassallo D. J. 1 Toxicology & Toxicology 2 Product Safety & Central Product Safety, Central Product Safety, 1 1 . . M. Singh , H. J. Beck , H. J. M. Klausner 2 2
2 , , M. Quijano 1 1 product safety, Toxicology, Toxicology, product safety, 2 , P. Riley , P. C. Goebel 1 , J. Kubilus, Kubilus, Hayden, J. G. R. Jackson, P. , S. Fulzele 1 TOXICOLOGY, Cosmital SA, Marly, Cosmital SA, Marly, TOXICOLOGY, 1 Auburn University, Auburn, AL, Auburn, Auburn University, . 1 2 and J. Lepoittevin and J. MA. Ashland, Corporation, MatTek . and M. K. Prinsen 1 3 3 1 .
Kubilus Y. Kaluzhny and M. Klausner. R & D, MatTek MatTek R & D, and M. Klausner. Kaluzhny Y. MA. Ashland, Corporation, TESTING OF HOUSEHOLD EYE IRRITANCY VITRO THE IN IN CLEANING PRODUCTS DEVELOPMENT OF AN IMPROVED AN IMPROVED DEVELOPMENT OF FOR TEST PROTOCOL EPIOCULAR Scheffler ISOLATED CHICKEN EYE (ICE) ASSAY. CHICKEN EYE (ICE) ISOLATED of Pharmacy, Florida A&M University, Tallahassee, Tallahassee, A&M University, Florida of Pharmacy, REGISTRATION OF CHEMICALS IN OF CHEMICALS REGISTRATION DERMAL PENETRATION VITRO IN EUROPE: Moore Netherlands. SCREENING OF SEVERE OCULAR IRRITANTS. Cambridgeshire, United Kingdom. Sponsor: Procter & Gamble, Cincinnati, OH and Procter & Gamble, FOUND IN JET FUELS. A. Chatterjee FL and Dobson Switzerland and A. Strong and K. McEwen, A. B. STUDIES. Rushden, BioDynamics Research Limited, Dummer. United Kingdom. Sponsor: R. Harling MODELS TO PREDICT THE PREDICT TO MODELS VITRO IN Regulatory Affairs, Procter & Gamble Eurocor, Eurocor, Procter & Gamble Affairs, Regulatory Belgium and Strombeek-Bever, de Dermatochimie, Universite Louis Pasteur, Louis Pasteur, de Dermatochimie, Universite France. Strasbourg, A MODEL AS OF EPIDERM EVALUATION AFTER EXPOSURE IRRITATION STUDY TO HYDROCARBONS ALIPHATIC VARIOUS TO INTEGRATION OF THE 3R’S IN CHEMICAL OF INTEGRATION Wilkins, S. Waterson, TESTING. L. TOXICITY Huntingdon Life Sciences, Wing. Rees and M. P. Schutte F. G. Gerberick G. F. F. Gerberick Sponsor: F. Darmstadt, Germany. METABOLISM OF AROMATIC AMINES AMINES AROMATIC OF METABOLISM VIVO THE SKIN. IN DEVELOPMENT OF A METABOLISM- DEVELOPMENT OF FOR ASSAY PEPTIDE REACTIVITY BASED THE SKIN SENSITIZATION SCREENING OF PROHAPTENS. POTENTIAL Applied Pharmacology, TNO Quality of Life, Zeist, Applied Pharmacology, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1594 #1593 #1589 10:30 AM–12:00 NOON Attended: 10:30 #1588 : R. J. Babu, Auburn University, Auburn, AL and John AL and John Auburn, University, Auburn Babu, Chairperson(s): R. J. MD. Sciences, Inc., Gaithersburg, Vitro In Harbell, Institute for NOON AM–12:00 9:00 Displayed: 9:00 AM to 12:00 NOON 9:00 Exhibit Hall ASSESSMENT MODELS FOR ALTERNATIVE POSTER SESSION: TOXICITY AND DERMAL OF OCULAR Wednesday, March 8 March Wednesday, #1591
#1592 Program Description Description Program #1590
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 #1609 A TWO-TIER APPROACH FOR EVALUATING 9:00 AM to 12:00 NOON THE RELEVANCE OF MULTIROUTE Exhibit Hall EXPOSURES IN ESTABLISHING DRINKING WATER GOALS FOR VOLATILE ORGANIC 2 1 POSTER SESSION: RISK ASSESSMENT I CHEMICALS. R. Carrier and K. Krishnan . 1SEST, University of Montréal, Montréal, QC, Chairperson(s): George Alexeeff, CAL EPA, Oakland, CA and David Canada and 2Water Quality and Health Bureau, Mattie, AFRL, Wright Patterson Air Force Base, OH. Health Canada, Ottawa, ON, Canada.
Displayed: 9:00 AM–12:00 NOON #1610 PROBABILISTIC MODEL FOR MICROBIAL RISK ASSESSMENT IN RECREATIONAL Attended: 9:00 AM–10:30 AM WATERS. J. K. Tolson1, 2, C. P. Villaroman2, E. M. Tufariello1, S. R. Custance2, R. Lanyon3, T. #1602 RISK ASSESSMENT FOR PCBs IN DRINKING C. Granato3, J. Zmuta3 and C. J. Petropoulou2. WATER. J. Avalos1, R. A. Howd2 and R. Brodberg1. 1GeoSyntec Consultants, Tampa, FL, 2GeoSyntec 1OEHHA, Cal/EPA, Sacramento, CA and 2OEHHA, Consultants, Baton Rouge, LA and 3Metropolitan Cal/EPA, Oakland, CA. Water Reclamation District of Greater Chicago, #1603 PREDICTION OF THE HEALTH EFFECTS Chicago, IL. OF POLYCHLORINATED BIPHENYLS #1611 RISK OF CRYPTOSPORIDIUM INFECTION (PCBs) AND THEIR METABOLITES USING AMONG BALTIMORE URBAN ANGLERS. QUANTITATIVE STRUCTURE TOXICITY J. D. Roberts1, 2, E. K. Silbergeld2 and T. Graczyk3. RELATIONSHIP (QSTR). P. Ruiz, O. Faroon, H. 1ChemRisk, Inc., San Francisco, CA, 2Department Hansen and M. Mumtaz. CDC/ATSDR, Atlanta, GA. of Environmental Health Sciences, Johns Hopkins #1604 DEVELOPMENTAL EFFECTS ASSOCIATED University, Bloomberg School of Public Health, WITH ENVIRONMENTAL PCB EXPOSURE: Baltimore, MD and 3Department of Molecular A REANALYSIS THROUGH EXPOSURE Microbiology and Immunology, Johns Hopkins STANDARDIZATION AND SYSTEMATIC University, Bloomberg School of Public Health, APPLICATION OF CAUSALITY CRITERIA. Baltimore, MD. N. El Majidi1, M. Bouchard2, 1, N. Gosselin1, #1612 D. Schoen3 and G. Carrier1, 2. 1Occupational & ASSESSMENT OF LA SEWAGE SPILLS ON S. Hong1, D. Environmental Health, Universite de Montréal, SANTA MONICA BAY BEACHES. Proctor1 and B. Finley2. 1Exponent, Irvine, CA and Montréal, QC, Canada, 2Institut national de sante 2ChemRisk, SanFrancisco, CA. publique du Quebec, Montréal, QC, Canada and 3Health Canada, Longueuil, QC, Canada. #1613 HEALTH RISK ASSESSMENT OF CHLOROBENZENEDIAMINE IN DRINKING #1605 PCB CONGENER-SPECIFIC RISK WATER. V. S. Bhat, G. L. Ball, C. J. McLellan and ASSESSMENT. J. Yang and A. G. Salmon. C. D. Gillilland. NSF International, Ann Arbor, MI. OEHHA, Cal/EPA, Oakland, CA. Sponsor: M. Dourson. #1606 DERIVATION OF A DRINKING WATER #1614 MEASUREMENT OF BLOOD IGE ACTION LEVEL FOR TRIETHYL IN INDIVIDUALS EXPOSED TO PHOSPHATE. C. J. Inhof1, M. H. Whittaker1, K. OHMICHI1, M. A. Gebhart2 and F. Hammer2. 1ToxServices, FORMALDEHYDE. Komiyama1, 2, 3, Y. Matsuno1, 2, 3, Y. Sawabe4, Washington, DC and 2Underwriters Laboratories, H. Miyaso1, E. Todaka1, 2, 3, H. Fukata1, 2, M. Inc., Northbrook, IL. Ohmichi5, T. Kadota1, 2, F. Nomura4 and C. Mori1, #1607 CLASS-BASED DRINKING WATER ACTION 2, 3. 1Department of Bioenvironmental Medicine, LEVEL FOR ISOBORNYL ACRYLATE Graduate School of Medicine, Chiba University, ISOMERS. M. H. Whittaker1, A. Gebhart2 and F. Chiba, Japan, 2Center of Environmental Health Hammer2. 1ToxServices, Washington, D.C., DC and Science for Future Generations (NPO), Chiba, 2Underwriters Laboratories, Northbrook, IL. Japan, 3Center for Environment, Health and Field Sciences, Chiba University, Kasiwa, Japan, #1608 DEVELOPMENT OF A HUMAN 4Department of Molecular Diagnosis, Graduate HEALTH-BASED DRINKING WATER School of Medicine, Chiba University, Chiba, Japan MAXIMUM CONTAMINANT LEVEL FOR and 5Chiba City Social Welfare Administrative PERCHLORATE. G. B. Post1 and P. Cohn2. Office, Chiba, Japan. 1Science, Research, and Technology, New Jersey Department of Environmental Protection, Trenton, #1615 NON-CYTOTOXIC CELL PROLIFERATION NJ and 2Environmental Health Service, NJ AS A SUBCOMPONENT OF THE MODE OF Department of Health and Senior Services, Trenton, ACTION FOR FORMALDEHYDE-INDUCED NJ. CARCINOGENESIS. C. Thompson1 and R. C. Grafstrom2. 1ORD/NCEA-W, U.S. EPA, Washington, DC and 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Sponsor: S. Barone. WEDNESDAY up-to-date information at www.toxicology.org 189 . 4 , 3
2 , B. , B.
, H. 2 Reckitt U.S. U.S. 4 , K. E. 2 and 1 4 . , L. Oak 1 1 Syracuse 2 . F. J. J. , F. GeoSyntec 2 R. Budinsky . ChemRisk, 2 2 , Global Product 1 M. Mumtaz , M. Fransen
. 1 2, 1 , J. B. Leikin B. , J. 1 1 and K. M. Portier The Dow Chemical The Dow 4 3 , A. R. Speed , Annual Meeting Annual 4 University of Florida, University , F. A. Heitfeld A. , F. 4 1 Biostatistics, Virginia Virginia Biostatistics, th 1 The Dow Chemical The Dow , W. Carter, Jr. Carter, W. , , A. Jespers , . 3 1 1 3 The Weinberg Group LLC, Weinberg The , C. Harper 1 1 and K. Fehling J. K. Tolson K. , J. . 1 3 Sara Lee HBCR, The Hague, Sara Lee HBCR, and K. Blackman 2 1 D. A. Daggett D. Agency for Toxic Substances Toxic for Agency S. M. Roberts 1 , T. Petry T. . 3 SOT's 45 SOT's 1 and J. D. Hamilton D. and J. S.C. Johnson, Racine, WI and S.C. Johnson, Racine, 1 , A. M. Carrao , 3 1 , C. Gennings , N. Roney , N. MODEL FOR PREDICTING 1 1 and E. Carney 2 R. A. Mascarenhas , R. S. Milanez 3
C. J. Saranko C. J. , S. Ren 1 GeoSyntec Consultants, Tampa, FL, FL, Tampa, GeoSyntec Consultants, Department of Homeland Security, FEMA, FEMA, Department of Homeland Security, Northwestern Healthcare - OMEGA, Evanston EPA, Cincinnati, OH and Cincinnati, EPA, Joachim San Francisco, CA. San Francisco, Ridge National Laboratory, Oak Ridge, TN and Oak Ridge, Ridge National Laboratory, DC. Washington, AMMONIUM ASSESSMENT: RISK IL. Glenview, VOLATILE ASSESSMENT OF RISK AIR EMISSIONS FROM CONTAMINANT J. B. Taylor B. J. Pfizer Global Toxicology, Molecular & Investigative Groton, CT. Research & Development, METHODS FOR HANDLING STATISTICAL CONGENER CENSORED DIOXIN/FURAN DATA. Hansen, H. Hicks, P. Ruiz and C. De Rosa. CDC/ Hansen, H. Hicks, P. Atlanta, GA. ATSDR, TOXICITY. OF CYANIDE AN OVERVIEW Consultants, Baton Rouge, LA, Gainesville, FL. OF DIOXINS/ ORAL BIOACCESSIBILITY INDUSTRIAL SOILS USING FURANS FROM J. TRACT. HUMAN G.I. A SIMULATED Finley B. Warmerdam, Netherlands, SIMILARITY IN DOSE-RESPONSIVENESS FOR MIXTURES OF MANY CHEMICALS. L. G. Stork ASSESSMENT OF CHEMICAL MIXTURES AND DISSIMILAR OF SIMILAR TOXICITY. MECHANISMS OF A. Fowler and B. IN SILICO PHOSPHOLIPIDOSIS-INDUCING Greene and N. Pelletier D. POTENTIAL. 1 ACUTE EXPOSURE GUIDELINE LEVELS EXPOSURE ACUTE TETRANITROMETHANE (AEGLS) FOR (TNM). 2 CLEANING BIFLUORIDE IN INDUSTRIAL APPLICATIONS. Long 2 FRESHENERS. Safety, JohnsonDiversey, Inc., Sturtevant, WI and Inc., Sturtevant, JohnsonDiversey, Safety, Teuschler Company, Midland, MI. Midland, Company, Research Corp, Syracuse, NY. THE PKA-CLOGP OF STUDY VALIDATION A Universtiy of. Vedula of. Universtiy D. Bradshaw D. Benckiser, Hull, United Kingdom. Benckiser, OF SUFFICIENT EMPIRICAL EVALUATION B. Landenberger B. Brussels, Belgium, Company, Midland, MI and Midland, Company, and Disease Registry, Atlanta, GA and and Disease Registry, Commonwealth University, Richmond, VA, VA, Richmond, University, Commonwealth
(Continued) Annual Annual th #1625 #1626 #1631 #1629 #1632 #1624 #1628 #1630 #1627 45 , 190 . 2 Meeting & ToxExpo & Meeting 1, , D. , D. 1 , . 5 3 A.
National H. 2 The G. , G. 5 2 , X. Wang , X. 2 E. Zahalka and H. Seung. SCREENING G. Johanson G. . , R. Atsumi1, , R. , K. Paigen 2 5 PhysioGenix, Inc., PhysioGenix, 1 Curriculum in . 1 Department of . 3 2, 1 and J. Liesivuori and J. B. Bradford , B. Southern Research 2, 1 2 Daiichi Pharmaceutical 3 2 , M. Hessner 1 1 E. Zahalka . H. Seung and
1 , M. Bogue , R. D. May , R. D. . Toxicty Evaluation Evaluation Toxicty . leach G. 1 4, 1 Medical College of Wisconsin, Wisconsin, of Medical College I. Rusyn 2 , J. Jarnberg , J. , L. Balletta 2 , H. Vernon , H. 2 and 1 and H. J. Jacob and H. J. 3, 1 2, 1 R. Tennant , R. 4 , P. Ross , P. , J. Baye , J. 1 1, 2 University of Kuopio, Kuopio, Finland. Kuopio, of Kuopio, University , A. Alexandrie A. , Karolinska Institute, Stockholm, Sweden, Environmental Sciences and Engineering, UNC- Environmental NC and Park, Triangle NIEHS, Research Milwaukee, WI and Milwaukee, O. Okazaki1 and K. Sudo O. D. Threadgill D. Hill, NC, UNC-Chapel Hill, Chapel Toxicology, Gene Logic, Inc., Gaithersburg, MD. Inc., Gaithersburg, Gene Logic, TO APPROACHES TOXICOGENOMICS PHOSPHOLIPIDOSIS: DRUG-INDUCED VITRO OF IN ESTABLISHMENT 2 1 3 Osaka, Japan. OF HUMAN ASSESSMENT RISK ANTICANCER BY MYELOTOXICITY A PREDICTIVE MODEL USING DRUGS: AND DERIVATIVES FIVE CAMPTOTHECIN COLONY FORMING UNIT VITRO THE IN (CFU-GM) GRANULOCYTE/MACROPHAGE Masubuchi N. ASSAY. . Pharmaceutical Research Takami Nakashita and K. Limited, Pharmaceutical Company Takeda Division, Evans Chapel Hill, Chapel Hill, NC, Chapel Hill, Chapel Hill, Chapel Hill, NC, Genetics, UNC-Chapel Hill, 4 TIME AND DOSE-DEPENDENT FACTORS FACTORS AND DOSE-DEPENDENT TIME TO IN GENETIC SUSCEPTIBILITY HEPATOTOXICITY. ACETAMINOPHEN Boorman 2 SYSTEM AND IDENTIFICATION OF AND IDENTIFICATION SYSTEM BLOOD BIOMARKERS. CANDIDATE Y. Dragan WI. Sponsor: Y. Milwaukee, EVALUATION OF THE DRUG INTERACTION INTERACTION THE DRUG OF EVALUATION ADMINISTERED BETWEEN DESIPRAMINE ADMINISTERED AND MORPHINE ORALLY ON EFFECTS SUBCUTANEOUSLY: AND ANTINOCICEPTIVE RESPONSE LETHALITY IN RATS. R. J. Roman R. J. program, U.S. Army Center for Health Promotion Army U.S. program, Ground, Aberdeen Proving Medicine, and Preventive MD. OF EVALUATION GROUP: NORDIC EXPERT AMMONIA. RISKS OF HEALTH Institute, Birmingham, AL. Institute, Birmingham, OF RDX IN TOXICITY ORAL SUBCHRONIC FISCHER 344 RATS. Hege Institute for Working Life, Stockholm, Sweden and Sweden Life, Stockholm, Working Institute for Sawada, K. Taniguchi, I. Mori, T. Iwachido, Y. Y. Iwachido, T. I. Mori, Taniguchi, K. Sawada, Gene Logic, Inc., Gaithersburg, MD. Inc., Gaithersburg, Gene Logic, INTERACTION THE DRAG OF EVALUATION ADMINISTERED BETWEEN DESIPRAMINE ADMINISTERED AND COCAINE ORALLY EFFECTS ON INTRAPERITONEALLY: LETHALITY IN RATS. Jackson Laboratory, Bar Harbor, ME. Bar Harbor, Jackson Laboratory, FOR SIGNATURES TOXICITY DRUG THE USING ACETAMINOPHEN S. H. Nye OF RATS. PHARMGENIX PANEL Co., Ltd., Tokyo, Japan and Tokyo, Co., Ltd., 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1620 #1621 #1616 #1618 #1623 #1622
#1619 Program Description Description Program #1617
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1633 THE ABSORPTION AND METABOLISM #1641 SYSTEMS BIOLOGY MODELS FOR OF INHALED BENZO(A)PYRENE IN THE INTEGRATION OF DIVERSE STUDIES OF ISOLATED AND PERFUSED RAT LUNG THE DEVELOPING NEOCORTEX AFTER DOES NOT INCREASE LINEARLY WITH EXPOSURE TO LOW DOSE RADIATION INCREASING EXPOSURES. P. Ewing, A. FROM EXTERNAL AND INTERNAL Ryrfeldt and P. Gerde. Environmental medicine, SOURCES. W. C. Griffith, N. M. DeFrank, J. Karolinska Institutet, Stockholm, Sweden. M. Gohlke, E. J. Gribble and E. M. Faustman. Environmental and Occupational Health Sciences, #1634 EXPOSURE AND RISK ASSESSMENT FOR University of Washington, Seattle, WA. PERFLUOROOCTANOATE (PFOA) IN APPAREL AND CARPETING. T. Roth1, W. Knaup2, C. Ho3, R. Jung1 and H. Panke4. 1CPS Wednesday, March 8 Toxicology, Clariant GmbH, Sulzbach a.T., 9:00 AM to 12:00 NOON Germany, 2R&D Fluorotelomers, Clariant GmbH, Exhibit Hall Burgkirchen, Germany, 3Corporation Analysis Laboratory, Clariant Corporation, Charlotte, NC and POSTER SESSION: CARCINOGENESIS—MODULATION 4TLP, Claraint GmbH, Frankfurt, Germany. Sponsor: G. Kennedy. Chairperson(s): Samuel Cohen, University of Nebraska Medical Center, Omaha, NE and Robert Schiestl, University of California Los Angeles, Los #1635 AN EVALUATION OF THE MUTAGENIC Angeles, CA. MODE OF ACTION FOR FOUR ENVIRONMENTAL CARCINOGENS. N. Displayed: 9:00 AM–12:00 NOON Keshava, G. M. Woodall, S. Rice, B. Sonawane and I. Cote. Office of Research and Development, Attended: 10:30 AM–12:00 NOON Environmental Protection Agency, Washington, DC. #1642 CHEMOPREVENTION OF EARLY STAGE PROSTATE CARCINOGENESIS BY GAMMA- #1636 PUSHING THE ENVELOPE: PRELIMINARY TOCOPHEROL IN PROBASIN/SV40 T METHODOLOGY FOR INCIDENT-BASED ANTIGEN TRANSGENIC RATS. K. takeshita1, RISK ASSESSMENT FOR BIOTHREAT S. Takahashi1, S. Azman1, S. Sugiura1, M. Tang1, K. 1 1 AGENTS. T. Nichols , I. Baumel , C. Sonich- Abe2 and T. Shirai1. 1Experimental Pathology and 1 2 2 2 Mullin , T. Bill , T. Negley , S. Massulik , M. Tumor Biology, Nagoya City University Graduate 2 2 2 2 Odin , P. McClure , P. Coleman , D. A. Gray and School of Medical Sciences, Nagoya, Japan and 2 1 P. McGinnis . U.S. EPA, Cincinnati, OH and 2Eisai Co., Ltd., Tokyo, Japan. 2Syracuse Research Corporation, Syracuse, NY. #1643 ANTIOXIDANT N-ACETYL CYSTEINE #1637 QUICK REFERENCE LIST OF TOXINS AND PREVENTS LYMPHOMA IN ATM DEFICIENT POTENTIAL CLINICAL MANIFESTATIONS. MICE. R. H. Schiestl and R. Reliene. UCLA, Los 1, 2 1 M. J. Stratton . Moxie Jean Stratton, Touro Angeles, CA. University College of Osteopathic Medicine, Napa, CA and 2Undergraduate Degree in Liberal Arts ‘99, #1644 EFFECT OF CELECOXIB ON Sarah Lawrence College, Bronxville, NY. CYTOCHROME P450 EXPRESSION IN A RAT HEPATOCARCINOGENESIS MODEL. M. E. #1638 ESTABLISHING “SAFE DRUG CARRYOVER Salcido-Neyoy1, A. Sierra-Santoyo2, L. Marquez- LEVELS” (SDCLS) IN MEDICATED ANIMAL Rosado1 and S. Villa-Trevino1. 1Cell Biology FEEDS. E. R. Nestmann and B. S. Lynch. CANTOX Department, CINVESTAV-IPN, Mexico City, D.F., Health Sciences Intl., Mississauga, ON, Canada. Mexico and 2Toxicology Section, CINVESTAV-IPN, #1639 USE OF MULTI-CRITERIA DECISION Mexico City, D.F., Mexico. ANALYSIS TOOLS TO FACILITATE WEIGHT- #1645 DEVELOPMENT OF NOVEL NITRATES FOR OF-EVIDENCE EVALUATION IN HUMAN COLON CANCER CHEMOPREVENTION. 1 HEALTH RISK ASSESSMENT. I. Linkov , K. F. G. K. Hagos1, V. Toader1, Q. Li1, D. D. Lantvit1, 1 1 2 3 Satterstrom , L. Green , G. Kiker and T. Bridges . S. Swanson1, R. E. Carroll2 and G. R. Thatcher1. 1 Cambridge Environmental Inc., Cambridge, 1Medicinal chemistry and Pharmacognosy, 2 MA, University of Florida, Gainesville, FL and University of Illinois, chicago, IL and 2Chicago 3 Engineer Research and Development Center, U.S. Veterans Administration Medical center, chicago, IL. Army Corps of Engineers, Vicksburg, MS. #1646 ALTERATIONS IN POLYCYCLIC AROMATIC #1640 USE OF BMC MODELING AND HYDROCARBON INDUCED PHASE I AND II CATEGORICAL REGRESSION TO ENZYME ACTIVITIES IN FEMALE MICE: EVALUATE ACUTE SENSORY IRRITATION ROLE OF CHEMOPREVENTIVE AGENTS. S. FROM CHLOROPICRIN VAPOR. L. T. Haber, E. R. Kondraganti, L. Wang, W. Jiang, K. Muthiah and Hack and M. L. Dourson. TERA, Cincinnati, OH. B. Moorthy. Pediatrics, Baylor College of Medicine, Houston, TX. WEDNESDAY up-to-date information at www.toxicology.org 191 . , 2 3, A. , C. 1 , , 1 . NTP, NTP, 2
, B. Stang , B. , M. Cano, C. Wilson , C. 1, 2 , J. K. Dunnick , J. 1 , E. E. Cole 1 Scientific 1 Detroit R&D, Inc., Detroit R&D, . 1 1 Annual Meeting Annual . 1 th R. Cope
Veterinary Biosciences, Veterinary 1 , E. S. Roberts-Kirchhoff . 2 1, 2 , A. Ignagni , 3 M. L. McCaskill
, L. H. Williams , L. H. 1 J. Borlak G. Gazzana and J. SOT's 45 SOT's and Y. Yuan Y. and 1 H. Kim
J. E. Leakey and J. . University of Nebraska S. M. Cohen. University Institute of Environmental Health Institute of Environmental 1 2 F. W. W. MICE. F. TRANSGENIC trp53(+/-) 1 N. Kerkvliet and N. 1 Department of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, , S. M. Lewis 3
1 Environmental and Molecular Toxicology, Oregon Oregon Toxicology, and Molecular Environmental Hornik-Rosinski V. , Oregon State University, Corvallis, OR and Corvallis, State University, Oregon State University, Corvallis, OR. Corvallis, State University, ON EFFECTS OF MELATONIN (DMA)-INDUCED ACID DIMETHYLARSINIC OF AND PROLIFERATION CYTOTOXICITY Clark and N. and SEARCH FOR DISEASE BIOMARKERS IN WITH HEPATOCELLULAR OF MICE SERUM CARCINOMA. INDOLE-3-CARBINOL. Loehr 2 THE BLADDER EPITHELIUM OF FEMALE Arnold L. L. Ohnishi, T. F344 RATS. ETHYL ACID SYNTHESIS OF FATTY BIOLOGICAL MARKERS FOR AS ESTERS ALCOHOL OF FETAL THE DIAGNOSIS SYNDROME. 1 K. Fleischmann Detroit, MI, THE INDUCTION OF SUPEROXIDE SUPEROXIDE THE INDUCTION OF OF AND INHIBITION DISMUTASE DNA INDUCED DIETHYLSTILBESTEROL SULFIDE IN DIALLY STRAND BREAKS BY MCF10A CELLS. FL. Tallahassee, A&M University, Florida AND TRANSPLACENTAL EFFECT OF OF ZIDOVUDINE EXPOSURE POSTNATAL ON AND LAMIVUDINE (3TC) (AZT) IN GENE EXPRESSION MITOCHONDRIAL C3B6F Lee W. T. Allaben T. W. AR and Coordination, NCTR, Jefferson, Fraunhofer Institut of Toxicology and Experimental Toxicology Institut of Fraunhofer Germany. Medicine, Hannover, Medical Center, Omaha, NE. Medical Center, MI Detroit, State University, Wayne Sciences, R. Thomas and R. Tucker A. , L. Russel, Aboyade-Cole University of Detroit Mercy, Detroit, MI. of Detroit Mercy, University NIEHS, Reseach Triangle Park, NC. Park, Triangle NIEHS, Reseach NON- RADIATION-INDUCED ULTRAVIOLET THE SKH: MELANOMA SKIN CANCER IN AUGMENTATION HR HAIRLESS MOUSE: BY TUMOR MULTIPLICITY OF BY AND PROTECTION CHLOROPHYLLIN
(Continued) Annual Annual th #1657 9:00 AM to 12:00 NOON 9:00 Exhibit Hall BIOMARKERS TOXICITY AND DISEASE POSTER SESSION: Goering, Peter and WA Richland, Battelle, Lee, Kyeonghee Chairperson(s): MD. Rockville, USFDA, AM–12:00 NOON 9:00 Displayed: AM AM–10:30 Attended: 9:00 #1658 #1654 #1655 Wednesday, March 8 March Wednesday, #1659 #1656 45 192
4 Meeting & ToxExpo & Meeting , 3 - 1 and , T. T. , 2 M. . 1 E. P. E. P. M. R. K. B. C. C. , B. 2, 3
. James P. James P. , M. 2 1 Physiol/ and 2 2 , R. E. Felgar , K. Taya , K. 3 1 , K. Serikawa Human Biology, Human Biology, 1, 2 1 . Arkansas Children’s Arkansas Children’s 3 1, 2 R. Singhal C. M. Weghorst C. M. T. M. Badger and T. T. E. Massey and T. , J. C. Roberts , J. 1 , T. Tanimoto T. , X. Zhang 1, 3 , N. Chiorazzi , N. 2 2 Environmental Medicine, Environmental . 1 . North Shore-LIJ Health System, 1, 2, 4 and H. Zarbl 3 3 Pathology, Sasaki Institute, Tokyo, Tokyo, Sasaki Institute, Pathology, 1 . 1 , J. G. Lamb , J. , L. L. Bedard Veterinary Physiology, Tokyo University University Tokyo Physiology, Veterinary University of Utah, Salt Lake City, UT City, of Utah, Salt Lake University 1 M. J. Ronis , M. J. 2 1 3 . , G. Watanabe , G. 1 1 , S. H. Bernsetin Environmental and Occupational Health Environmental , E. Pearson and T. T. and Stoner, E. Pearson D. , C. L. Sardo, G. 1 2 University of Wisconsin, Madison, WI. Madison, Wisconsin, of University 2 Pathology and Laboratory Medicine, University of and Laboratory Medicine, University Pathology Pharmacology/ Toxicology, University of Arkansas of University Toxicology, Pharmacology/ Microbiology, University of Washington, Seattle, Seattle, Washington, of University Microbiology, Franklin J. Knobloch. The Ohio State University, Columbus, The Ohio State University, Knobloch. J. Wilmot Cancer Center, University of Rochester, of Rochester, University Cancer Center, Wilmot NY, Rochester, Rochester, Rochester, NY. Rochester, Rochester, Institute for Medical Research, Manhasset, NY and 4 C. Tohyama Sponsor: C. ACTIVATION- AND CONSTITUTIVE INDUCIBLE CYCLOOXYGENASE-2 SURVIVAL PROMOTES ACTIVITY HUMAN CHRONIC OF PRIMARY CELLS. LEUKEMIA B LYMPHOCYTIC Ryan Japan and 1 AR, for Medical Sciences, Little Rock, A. Maekawa OF L-SELENOCYSTEINE ON CHEMOPREVENTIVE ENZYMES IN MICE M. El Sayed W. CELLS. AND HEPA1C1C7 and A. Guindon ORAL CANCER CHEMOPREVENTION BY ORAL CANCER CHEMOPREVENTION RASPBERRIES. BLACK Casto OH. B AFLATOXIN VIVO PREVENTION OF IN USE OF GENE EXPRESSION PROFILING PROFILING USE OF GENE EXPRESSION MECHANISM OF SELENIUM STUDY TO MAMMARY OF RAT CHEMOPREVENTION CARCINOGENESIS. 3 WA. R. Bumbgarner Aboul Fadl Yoshida Japan. Tokyo, Technology, Agriculture and of NY, Rochester, of Rochester, University Sciences, University of Washington, Seattle, WA and WA Seattle, Washington, of Sciences, University and R. P. Phipps and R. P. INDUCED 8-HYDROXYDEOXYGUANOSINE INDUCED 8-HYDROXYDEOXYGUANOSINE CELLS BY IN MOUSE LUNG FORMATION WITH POLYETHYLENE PRE-TREATMENT CATALASE. GLYCOL-CONJUGATED REDUCTION IN BASAL ARYL ARYL REDUCTION IN BASAL EXPRESSION RECEPTOR HYDROCARBON P450-1A1 INDUCTION AND CYTOCHROME CONSUMPTION. BY SOY AR. Little Rock, Nutrition Center, WITH TREATMENT LONG-TERM UTERINE INHIBITS RAT BROMOCRIPTINE ADENOCARCINOMA DEVELOPMENT. Biophys, University of Arkansas for Medical of University Biophys, AR and Sciences, Little Rock, Pharmacology and Toxicology, Queen’s University, University, Queen’s Toxicology, and Pharmacology Canada. Kingston, ON, EXPOSURE ACUTE EFFECTS OF PRODRUGS OF SELENAZOLIDINE Fergusson Fred Hutchinson Cancer Research Center, Seattle, Research Center, Hutchinson Cancer Fred WA, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1653 #1649 #1648 #1647 Program Description Description Program #1651 #1652 #1650
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1660 DISCOVERY OF CYSTATIN C AS A #1667 KIDNEY INJURY MOLECULE-1 (KIM-1) BIOMARKER OF CARDIAC CELL TYPE EXPRESSION IN KIDNEY AND URINE SPECIFIC OXIDATIVE INJURY WITH FOLLOWING ACUTE EXPOSURE TO SHOTGUN PROTEOMICS. L. Xie, Y. Lin and Q. GENTAMICIN AND MERCURY. P. L. Goering1, Chen. University of Arizona, Tucson, AZ. V. S. Vaidya3, R. P. Brown1, Z. Vakili1, B. A. Rosenzweig2, A. M. Johnson3, K. L. Thompson2 and #1661 PULMONARY RESPONSES OF AKR/J MICE J. V. Bonventre3. 1CDRH, USFDA, Silver Spring, EXPOSED TO CIGARETTE SMOKE AND/ MD, 2CDER, USFDA, Silver Spring, MD and OR LPS FOR 3-WEEK VIA NOSE-ONLY 3Brigham and Women’s Hospital, Harvard Medical INHALATION. K. M. Lee, R. A. Renne, S. J. Harbo, School, Boston, MA. J. C. Blessing, M. L. Clark, R. E. Johnson and K. M. Gideon. Toxicology NW, Battelle, Richland, WA. #1668 BIO-FLUIDS, THE DYNAMIC RANGE OF ABUNDANCES, AND THE APPROACH #1662 VALIDATION OF AN TOWARDS TOXICITY BIOMARKERS BY ELECTROCHEMILUMINESCENCE- PROTEOMICS OF RAT URINARY PROTEINS. BASED ASSAY FOR CARDIAC TROPONIN M. S. Mondal1, I. Tcholakov1, P. Dinsmoor1, A. T AND ITS KINETICS IN RAT SERUM Que2, M. Cabonce2, G. Stevens1 and S. Beushausen2. FOLLOWING EXPOSURE TO VARIOUS 1Worldwide Safety Sciences, Pfizer, Inc., La Jolla, CARDIOTOXICANTS. P. Nordone, R. Dunn, C. CA and 2Worldwide Safety Sciences, Pfizer, Inc., St. Afshari and S. Thukral. Amgen, Thousand Oaks, Louis, MO. CA. #1669 IDENTIFICATION OF EARLY BIOMARKERS #1663 KIDNEY INJURY MOLECULE-1 (KIM-1) AS OF TUBULAR TOXICITY IN SPECIFIC AN EARLY BIOMARKER OF CADMIUM RENAL SEGMENTS AND IN URINE IN A RAT 1 (CD) NEPHROTOXICITY. W. C. Prozialeck , MODEL OF NEPHROTOXICITY. A. Yang1, B. 2 2 3 3 V. S. Vaidya , A. Johnson , J. Liu , M. P. Waalkes , Jessen1, C. Fuentealba2, O. Illanes2 and F. Ramiro- 1 1 1 J. R. Edwards , E. Diamantakos , P. C. Lamar , J. Ibanez1. 1Pfizer Global Research & Development, 4 2 1 Theusch and J. V. Bonventre . Pharmacology, La Jolla Laboratories, San Diego, CA and 2Western Midwestern Universtiy of., Downers Grove, IL, University of Health Sciences, Pomona, CA. 2 Brigham and Woman’s Hospital, Harvard Medical Sponsor: G. Stevens. School, MA, 3NCI, Research Triangle Park, NC and 4Animal Resources, University of Chicago, Chicago, #1670 BIOMARKERS FOR DETECTING IL. MYOCARDIAL DAMAGE IN CYNOMOLGUS MONKEY. K. Nakama, H. Minomo, H. Kadokura, #1664 EXAMINATION OF HFE C282Y/H63D H. Uchino, Y. Torikai, K. Fukuzaki and R. Nagata. HETEROZYGOTES AS A POTENTIAL Shin Nippon Biomedical Laboratries, Kagoshima, HUMAN MODELING SYSTEM FOR LOW Japan. LEVEL LIVER DAMAGE. N. H. Johnson, C. Mauzy, D. Todd, J. Boyer, T. Minnick and S. Stevens. #1671 IS THERE A THRESHOLD LEVEL FOR Air Force Research Laboratory, Wright-Patterson ALTERATIONS IN THYROID HORMONE AFB OH, OH. CONCENTRATIONS IN THE PRODUCTION OF THYROID TUMORS IN F344/N RATS? G. #1665 CYTOCHROME C: A NON-INVASIVE Travlos1, G. Pearse1, L. Betz3, M. Hooth2 and E. BIOMARKER OF DRUG-INDUCED LIVER Harvey3. 1Laboratory of Experimental Pathology, TOXICITY. T. J. Miller, P. Espandiari, J. Zhang, NIEHS, Durham, NC, 2Toxicology Operations A. Knapton, J. L. Weaver, E. H. Herman and J. P. Branch, NIEHS, Durham, NC and 3Constella Health Hanig. CDER, USFDA, Silver Spring, MD. Sciences, Durham, NC. Sponsor: T. Brock. #1666 AGE- AND DOSE-RELATED SENSITIVITY IN 2-BUTOXYETHANOL F344 RAT MODEL OF Wednesday, March 8 HEMOLYTIC ANEMIA AND DISSEMINATED 9:00 AM to 12:00 NOON THROMBOSIS. Y. Ramot1, D. A. Lewis2, T. L. Exhibit Hall Ortel2, M. Streicker3, G. Moser3, S. Elmore3, S. Ward4, S. Peddada5 and A. Nyska4. 1Hadassah POSTER SESSION: SAFETY ASSESSMENT— Medical Center, Hebrew University, Jerusalem, PHARMACEUTICALS 2 (ONCOLOGY, ANTIINFLAMMATORY, Israel, 2Division of Hematology, Duke University ANTIINFECTIVES, EXCIPIENTS, NATURAL PRODUCTS) Medical Center, Durham, NC, 3ILS, Research Triangle Park, NC, 4Laboratory of Experimental Chairperson(s): Virginia Pinney, Engineering Systems Inc., The Pathology, NIEHS, Research Triangle Park, NC and Woodlands, TX. 5Biostatistics Branch, NIEHS, Research Triangle Park, NC. Displayed: 9:00 AM–12:00 NOON Attended: 10:30 AM–12:00 NOON #1672 INFLUENCE OF EXPOSURE SCENARIOS ON RESPONSE OF HUMAN GLIOMA CELLS TO PACLITAXEL. J. M. Padowski1, E. M. Leslie2 and G. M. Pollack2. 1Curriculum in Toxicology, UNC, Chapel Hill, NC and 2Division of Pharmacotherapy,
UNC, Chapel Hill, NC. Sponsor: D. Holbrook. WEDNESDAY up-to-date information at www.toxicology.org 193 , 1 , . . 1 2 , A. , 2 R. 1 , , K. 1 , L. Von Von , L. 1, 2 S. Amgen and 1 M. 1, 2 1 . , University University 2 1 1 . AstraZeneca R. C. Gupta 1 2, 1 , Enviromental Enviromental . 1 2 R. C. Gupta 3 Y. Fan Y. , C. Simms , M. D’Altilio , 1 1 1 D. Bagchi and D. D. Bagchi and D. , T. Sun T. , 2 2 1 M. Myers Charles River Charles River 2 Annual Meeting Annual H. Jarvelainen . th and J. Pletcher and J. 2 , M. Alvey , M. Department of Anatomy and Anatomy Department of 1 Department of Food and Department of Food , C. Simms M. D’Altilio 3 2 1 A. Nguyen and R. Heflich , M. Bagchi , M. Bagchi , 1 1 1 2, 1 and J. Tuukkanen and J. 3 SOT's 45 SOT's Pharmaceutical Sciences, Oregon 1 . , J. Goad , J. , M. Alvey , M. . Safety Sciences, Pfizer,Amacher and D. 1 1, 2 1 A. Ndifor , A. LaRochelle , InterHealth Nutraceuticals Inc., Benicia, InterHealth Nutraceuticals, Inc., Benicia, , F. Beland , F. 1 2 2 , T. Canerdy T. , 2 , A. Curtsinger , 1 1 , J. Ilvesaro , J. National Center for Toxicological Research, Toxicological National Center for 3 2 Toxicology, Murray State University, Hopkinsville, State University, Murray Toxicology, Toxicology, Murray State University, Hopkinsville, State University, Murray Toxicology, and Molecular Toxicology, Oregon State University, State University, Oregon Toxicology, and Molecular OR. Corvallis, A. Peal Curtsinger J. Goad J. T. Canerdy T. R&D, Lund, Sweden, Sweden, Lund, R&D, Tungeln OR and Corvallis, State University, 1 KY and CA. OF INTRA- SAFETY EVALUATION AND AMG 108 INJECTED ARTICULARLY WHITE KINERET IN NEW ZEALAND RABBIT. Cosenza Oaks, CA and Thousand Inc., Inc., Groton, CT. IN DNA DEPLETION OF MITOCHONDRIAL AFTER MUSCLE AND SKELETAL CARDIAC AND AZT TO EXPOSURE OF MICE IN UTERO ANTI- COMBINATION AZT-CONTAINING THERAPIES. RETROVIRAL and AND DEXAMETHASONE ON OSTEOCLAST AND DEXAMETHASONE AND BONE DIFFERENTIATION VITRO RESORPTION IN Nelo 1 KY and CA. THERAPEUTIC EFFICAY AND SAFETY II COLLAGEN TYPE OF UNDENATURED WITH AND IN COMBINATION ALONE, IN AND CHONDROITIN GLUCOSAMINE DOGS. ARTHRITIC Schomaker AR Arkansas for Medical Sciences, Little Rock, of R. Proteau Jefferson, AR. Jefferson, ON EFFECTS OF KETOCONAZOLE RESISTANT-MEDIATED MULTIDRUG MDCKII-MDR1 AND CACO-2 IN TRANSPORT MODELS. TRANSPORT DRUG THE EFFECTS OF A DISSOCIATED A DISSOCIATED THE EFFECTS OF LIGAND RECEPTOR GLUCOCORTICOID Laboratories, Worcester, MA. Worcester, Laboratories, TERM SHORT EFFECTS OF THE HEPATIC ADMINISTRATION DEXAMETHASONE L. Correia, E. R. Jackson, C. Kilroy, IN RATS. Joslin, I. Pruimboom-Brees, D. Parzych, B. Cell Biology, University of Oulu, Oulu, Finland. University Cell Biology, AND SAFETY THERAPEUTIC EFFICACY ACID-SX, (-)-HYDROXYCITRIC OF UC-II, AND CHROMEMATE GL, HYDROXYCITRIC- A. Peal DOGS. ARTHRITIC IN Environmental Hygiene, University of Helsinki, Hygiene, University Environmental and Helsinki, Finland
(Continued) Annual Annual th #1683 #1685 #1682 #1686 #1680 #1684 #1681 45 194 . I. . Meeting & ToxExpo & Meeting
, 2
2 , 1 C. D. and D. M. , 2 2 , , C. 3 1 National 3 Toxicology Toxicology T. L. Horn , T. 1 1 . 1 , C. J. Detrisac , C. J. and G. Benson F. A. Grzemski , F. 1 1 D. L. and D. R. Willis , R. J. Crowell , J. , A. Ahmad, Ahmad, A. S. Khan, 3 3
2 ® Cancer Biology, Cancer Biology, J. A. Crowell , J. 4 2 J. Engelhardt , J. Toxicology, Amgen, Toxicology, 4 1 Covance Laboratories, Covance 2 Robert Wood Johnson Wood Robert . Division of Cancer Division , K. Torres , K. 2 2 2 1 , K. Cooper 1 Toxicologic Pathology, Amgen, Pathology, Toxicologic , I. Hayward 3 1 W. D. Johnson D. , W. J. A. Crowell , J. 1 3 and A. Lyubimov IIT Research Institute, Chicago, IL 4 , R. A. Lubet , R. 1 , I. Kapetanovic 2 1 . IIT Research Institute, Chicago, IL, IIT Research Institute, Chicago, 1 , T. Polverino T. , 1 1 . 1 S. Wolford and S. 1 W. E. Maier , R. Guzman, W. M. D. Todd M. D. Y. Chen Y. T. L. Horn T. Roswell Park Cancer Institute, Buffalo, NY Cancer Institute, Buffalo, Park Roswell 3 National Cancer Institute, Bethesda, MD. Charles River Associates Division, Pathology 2 4 , R. Morrissey 3 McNeil Consumer & Specialty Pharmaceuticals, Pathology Associates, Chicago, IL and Pathology Prevention, National Cancer Institute, Bethesda, National Cancer Institute, Prevention, MD, McCormick Research Laboratory, University of Illinois University Research Laboratory, Inc., Thousand Oaks, CA, Thousand Inc., Zimmermann L. McCormick . Worldwide Safety Sciences, Worldwide Robertson. G. and D. MI. Arbor, Ann Pfizer Global R&D, TEST OF LIVER-FUNCTION PATTERNS TRIAL A LONG-TERM LEVELS DURING WITH IN SUBJECTS ACETAMINOPHEN OF Temple A. PAIN. OA 1 and PA Washington, Fort and Laboratories, Chicago, IL. AND TOXICITY RENAL A NOVEL OF HYPERBILIRUBINEMIA (MMP) METALLOPROTEINASE MATRIX IN CYNOMOLGUS MONKEYS. INHIBITOR K. Datta METHYLSELENOCYSTEINE (SEMC) IN RATS. Ip at Chicago, Chicago, IL, and ANTI-ANGIOGENIC SMALL MOLECULES ANTI-ANGIOGENIC SMALL MOLECULES AND BEAGLE RATS IN SPRAGUE-DAWLEY DOGS. Consenza J. Anwer, P. Chen, C. Dudkowski, J. Ayoub, J. J. Ayoub, J. Chen, C. Dudkowski, P. Anwer, J. Pharmacokinetics,Ahmad. Safety and Zang and I. IL. Waukegan, NeoPharm Inc., Efficacy, OF EVALUATION TOXICITY SUBCHRONIC IN FEMALE TARGRETIN + TAMOXIFEN RATS. 2 Oaks, CA and Thousand Inc., A UNIQUE LIPOSOMAL DOCETAXEL DOCETAXEL LIPOSOMAL A UNIQUE (LE-DT) EXHIBITS FORMULATION COMPARABLE SAFETY, IMPROVED THERAPEUTIC AND PHARMACOKINETICS TAXOTERE TO EFFICACY M. Kapetanovic I. M. Kapetanovic THIRTEEN WEEK ORAL (GAVAGE) WEEK ORAL (GAVAGE) THIRTEEN OF L-SE- STUDY TOXICITY Amgen, Inc., Thousand Oaks, CA. Amgen, Inc., OF EXPRESSION DIFFERENTIAL HEPATIC AND LIPID DRUG GENES REGULATING TO EXPOSED IN RATS METABOLISM Naylor J. TARGRETIN. M. Yuschak Sponsor: M. Medical School, Camden, NJ. Inc., Madison, WI, Inc., Madison, Cancer Institute, Bethesda, MD. TWO ASSESSMENT OF TOXICITY THE 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1679 #1678 #1674
#1673 Program Description Description Program #1677 #1676 #1675
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1687 EVALUATION OF THE ANTIMICROBIAL Wednesday, March 8 AND ANTIFUNGAL PROPERTIES OF 9:00 AM to 12:00 NOON EBSELEN. G. Chan, D. Hardej and B. Billack. Exhibit Hall Department of Pharmaceutical Sciences, St. John’s University, Queens, NY. POSTER SESSION: INHALATION METHODS AND DOSIMETRY #1688 EVALUATION OF PLURONIC®F127- Chairperson(s): Owen Moss, CIIT Centers for Health Research, Research BASED VEHICLES FOR DRUG DELIVERY Triangle Park, NC. BY ASSESSING STIMULATION AND INHIBITION OF HEMATOPOIETIC Displayed: 9:00 AM–12:00 NOON PROGENITOR PROLIFERATION WITH IN VITRO COLONY ASSAYS. J. M. Blonder1, W. Attended: 9:00 AM–10:30 AM Schauer1, A. Samaniego1, J. Damen2, E. Clarke2 and #1694 NON-INVASIVE ASSESSMENT OF G. J. Rosenthal1. 1RxKinetix, Louisville, CO and PULMONARY DISORDER USING 2StemCell Technologies, Vancouver, BC, Canada. COMPUTED TOMOGRAPHY (CT)-IMAGING #1689 DIETARY SUBCHRONIC TOXICITY AND IN A NON-HUMAN PRIMATE. N. Horai1, T. TERATOLOGY STUDIES AVICEL CL-611® Bando1, H. Kasai1, S. Nagayama1, H. Tokado1, K. IN SPRAGUE-DAWLEY RATS. D. Nuber1, C. Fukuzaki1, K. Abeyama2 and R. Nagata1. 1Shin Freeman2 and M. Weiner1. 1FMC Corporation, Nippon Biomedical Laboratories, Ltd., Kagoshima, Princeton, NJ and 2Formerly of FMC Corporation, Japan and 2Department of Preventive Medicine, Princeton, NJ. Kagoshima University Graduated School of Medicine and Dental Science, Kagoshima, Japan. #1690 REPEATED SUBCUTANEOUS DOSE TOXICITY STUDY OF DM401 IN MICE. W. S. #1695 THE ASSESSMENT OF RESPIRATORY Koh1, W. H. Choi1, Y. B. Kim1, C. S. Ha1, H. Lee2, PARAMETERS IN DOGS USING A NON– Y. D. Kwon3, O. M. Choi3, K. A. Cheong3 and Y. J. INVASIVE SPIROMETRY SYSTEM. H. Lee3. 1Korea Institute of Toxicology, Daejeon, South Campbell, D. Poulin, A. Viau and C. Banks. Korea, 2Samsung Medical Center, Seoul, South Toxicology, Charles River Laboratories Preclinical Korea and 3MEDIPOST, Seoul, South Korea. Montréal, Senneville, QC, Canada. #1691 SYSTEMIC EFFECT OF VACUUM-ASSISTED #1696 MEASUREMENT AND PREDICTION CLOSURE (V.A.C.®) THERAPY FOR 8 DAYS OF JUVENILE BEAGLE RESPIRATORY IN SWINE WITH CUTANEOUS WOUNDS. PARAMETERS FOR USE IN INHALATION K. C. Norbury1, M. Piacente2, R. Zirl3, B. Stouch1 DOSIMETRY ESTIMATES. J. Weinberg and D. and K. Kieswetter1. 1Kinetic Concepts, Inc., San T. Kirkpatrick. WIL Research Laboratories, LLC, Antonio, TX, 2Biological Test Center, Irvine, CA and Ashland, OH. 3Tejas Pathology, Tomball, TX. #1697 THREE MINUTE INHALATION OF #1692 INVESTIGATION OF THE HEPATOTOXICITY METHACHOLINE BY B6C3F1 OR BALB/C OF USNIC ACID USING A COMPENDIUM OF FEMALE MICE PRODUCES NO CHANGE IN RAT LIVER GENE EXPRESSION PROFILES. PRESSURE DROP ACROSS THE ISOLATED P. D. Cornwell1, A. T. De Souza1, G. Slatter1, J. C. UPPER RESPIRATORY TRACT. O. R. Moss Rockett1, M. J. Caguyong1, O. Cheng2, X. Dai2, Y. and E. W. Tewksbury. Computational Biology, CIIT D. He2 and R. G. Ulrich1. 1Preclinical Molecular Centers for Health Resesrch, Research Triangle Profiling, Rosetta Inpharmatics LLC (a wholly Park, NC. owned subsidiary of Merck & Co. Inc.), Seattle, #1698 PARTICLE DEPOSITION IN WA and 2Bioinformatics, Rosetta Inpharmatics LLC SPONTANEOUSLY HYPERTENSIVE (a wholly owned subsidiary of Merck & Co. Inc.), (SH) RATS EXPOSED VIA WHOLE-BODY Seattle, WA. INHALATION: MEASURED VS. ESTIMATED #1693 EFFECTS OF HERBA AGRIMONIA ON DOSE. L. B. Wichers1, W. H. Rowan2, J. P. Nolan2, CHEMICAL-INDUCED LIVER TUMOR IN A. D. Ledbetter2, J. K. McGee2, D. L. Costa2 and RATS. J. W. Ho and J. Song. Biochemistry, The W. P. Watkinson2. 1Environmental Sciences and Chinese University of Hong Kong, HK, Hong Kong. Engineering, University of North Carolina, Chapel Hill, NC and 2ORD/NHEERL/ETD/PTB, U.S. EPA, Research Triangle Park, NC. #1699 RABBIT EMBRYO-FOETAL INHALATION STUDIES - MAXIMISING OF DOSING POTENTIAL. S. A. Moore and C. J. Hardy. Inhalation Toxicology, Huntingdon Life Sciences Ltd., Huntingdon, United Kingdom. #1700 A REFINED METHOD OF RESTRAINT FOR DOGS USED IN INHALATION STUDIES. M. M. Hussain, A. C. Leach and C. J. Hardy. Inhalation Toxicology, Huntingdon Life Sciences Ltd., Huntingdon, United Kingdom. WEDNESDAY up-to-date information at www.toxicology.org 195 ,
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, D. , D. B. D. D. , B. 3 , T. T. , 2 3 2 Department J. F. F. , J. , C. North 3 2 1 P. E. Ganey , P. 1 Discovery Discovery 2 P. E. Ganey , P. 1 Cellular and E. A. Blomme , E. 1 3 . 2 Department of T. P. Reilly P. , T. Annual Meeting Annual 1 2 . th 3 J. P. Luyendyk P. , J. , T. Miyagishima T. , 1 J. F. Maddox F. , J. 2 1 R. F. Stachlewitz , R. F. 2 J. F. Maddox F. , J. 2 . M. J. Liguori , M. J. Department and of Pharmacology Department of Biochemistry and SOT's 45 SOT's 2 1 1 Pharmacology and Toxicology, Toxicology, and Pharmacology , A. Ono , Biology, University of Memphis, University Biology, . . 5 R. A. Roth and R. L. D. Lehman-McKeeman , L. D. 1 1 1 Department of Discovery Safety, Safety, Department of Discovery 1 1 Department and of Pharmacology 2 and T. Nagao T. and . 1, 2 2 1 , V. M. Bhaskaran V. , 1, 2 2 , M. J. Liguori , M. J. 1 P. E. Ganey , P. 2 . J. P. Luyendyk P. , J. 3 Drug Safety Evaluation, Bristol-Myers Squibb, Bristol-Myers Drug Safety Evaluation, Biology, University of Memphis, Memphis, TN. TN. of Memphis, Memphis, University Biology, G. H. Cantor , G. 3 7 2 Toxicogenomics Project, National Institute of Toxicogenomics Environmental Health Sciences, John Hopkins Environmental Metabolism and Pharmacokinetics, Abbott Metabolism and Pharmacokinetics, MA and Worcester, Bioresearch Center, Abbott Toxicology, of Molecular and Cellular IL. Abbott Park, Laboratories, Toxicology, Michigan State University, Lansing, MI. State University, Michigan Toxicology, IN OF LPS/TNF SIGNAL ANALYSIS VARIOUS OF THE HEPATOTOXICITY OF THE DATABASE CHEMICALS IN IN JAPAN. PROJECT TOXICOGENOMICS Institute of Health Sciences, Tokyo, Japan. Sponsor: Tokyo, Institute of Health Sciences, Inoue T. Maddox Waring Y. Mizukawa Y. Biomedical Innovation, Osaka, Japan and Biomedical Innovation, GENE COAGULATION-DEPENDENT IN LIVERS OF AND INJURY EXPRESSION WITH GIVEN LIPOPOLYSACCHARIDE RATS WITH FAMOTIDINE. NOT RANITIDINE BUT Bloomber School of Public Health, Baltimore, MD Bloomber School of Public Luyendyk P. J. A. R. Karuri Lansing, MI, 2 M. Nelson Car A. Roth and R. and A. Roth and R. Dartmouth Medical school, Hanover, NH, Dartmouth Medical school, Hanover, 6 and INHIBITION OF ACUTE ACUTE INHIBITION OF IN TOXICITIES LIPOPOLYSACCHARIDE 2-DITHIOLE-3-THIONE. -1, 3
(Continued) Annual Annual th #1709 #1710 #1707 #1711 #1708 45 196 Meeting & ToxExpo & Meeting , , H. 1 .
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, T. Tahara T. , , T. Senba T. , 1 1 and T. M. T. and 1 , S. Lake . Joint Graduate 1 , H. Jeffries 1 L. L. Lanning Biomedical 1 . and H. Goto 2, 1 1 V. Seaman V. ENVR, UNC-CH, Chapel ENVR, UNC-CH, Chapel 1 . , N. Ishiharada , N. 1 2, 1 J. D. Laskin D. and J. , S. Ebersviller 1 Environmental Toxicology, UC Toxicology, Environmental 2 CEMALB, UNC-CH, Chapel Hill, CEMALB, of University School of Pharmacy, , K. Morishita 2 2 1 A. J. Hickey and A. J. 1 Environmental Toxicology, UC Davis, UC Davis, Toxicology, Environmental . NIEM, Karolinska Institutet, Stockholm, . NIEM, Karolinska Institutet, 1 , M. Doyle . 1 1 and I. Jaspers , Y. Shimomura Y. , D. L. Laskin , D. 1 1 Otsuka Maryland Research Institute, Rockvill, 2
Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan Tokushima, Otsuka Pharmaceutical Co., Ltd., Sweden. AN AS PRECIPITATION ELECTROSTATIC VITRO METHOD FOR IN ALTERNATIVE REGULATION OF INFLAMMATORY OF INFLAMMATORY REGULATION THE LIVER IN PRODUCTION MEDIATOR ENDOTOXEMIA. ACUTE DURING Chen Program in Toxicology, Rutgers University and Rutgers University Toxicology, in Program Johnson Medical School, Wood UMDNJ-Robert NJ. Piscataway, Cahill Ueda 1 and TOXICOLOGY STUDIES. TOXICOLOGY VITRO FOR IN Hill, NC and Sexton Leith Hill, NC and NC. DIESEL DEVELOPMENT OF NOVEL AEROSOL PARTICLE EXHAUST AND DEPOSITION METHODS GENERATION SATURATION OF AIRWAY EPITHELIUM EPITHELIUM AIRWAY OF SATURATION TO EXPOSURES AFTER MODERATE ONE LIPOPHILIC CARCINOGENS: INHALATION CULPRIT BEHIND NEGATIVE ANIMALS? EXPOSURES IN LABORATORY Gerde P. EXPOSURES TO MIXTURES OF GASES TO EXPOSURES K. de Bruijne AND PARTICLES. N. Takahashi N. Davis, CA and Davis, TRACHEOTOMY TUBE. TRACHEOTOMY MD. AND ROBUST SENSITIVE A HIGHLY THE DETERMINATION METHOD FOR TOXIC AND OTHER ACROLEIN OF AIR. CARBONYLS IN North Carolina, Chapel Hill, NC. OF INSTILLATION INTRATRACHEAL CONSCIOUS MICE TO BLEOMYCIN D. Cooney D. Davis, Davis, CA. Davis, Davis, Engineering, University of North Carolina, Chapel Engineering, University 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1702 10:30 AM–12:00 NOON Attended: 10:30 #1706 : Jeffrey Laskin, University of Medicine and Dentistry of University Laskin, Chairperson(s): Jeffrey Medical & National Jewish NJ and Brian Day, Piscataway, Jersey, New CO. Denver, Center, Research AM–12:00 NOON 9:00 Displayed: Exhibit Hall LIVER I POSTER SESSION: 9:00 AM to 12:00 NOON AM to 9:00 #1703
#1701 Program Description Description Program #1705 #1704 Wednesday, March 8 March Wednesday,
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1712 LEFLUNOMIDE IS A POTENT INHIBITOR Wednesday, March 8 OF THE MITOCHONDRIAL PERMEABILITY 9:00 AM to 12:00 NOON TRANSITION PORE IN HEPATOCYTES. C. Exhibit Hall Latchoumycandane1, Q. Seah1, J. Sattabongkot2, 3 1, W. Beerheide and Universtiy of. A. Boelsterli POSTER SESSION: IN VITRO IMMUNOTOXICITY 4. 1Pharmacology, NUS, Singapore, Singapore, 2AFRIMS, Bangkok, Thailand, 3Siam Life Science, Chairperson(s): Stephen Bloom, Cornell, Ithaca, NY and Emanuela Pathumthani, Thailand and 4Pharmacy, NUS, Corsini, University of Milan, Milan, Italy. Singapore, Singapore. Displayed: 9:00 AM–12:00 NOON #1713 MITOCHONDRIAL ADENINE NUCLEOTIDE TRANSLOCATOR EXPRESSION IS Attended: 9:00 AM–10:30 AM DECREASED IN LIVER CELLS OF ZUCKER #1718 KUPFFER CELL/HEPATOCYTE FATTY RATS: RELEVANCE FOR ALTERED COCULTURE AS A MODEL TO ASSESS MITOCHONDRIAL BIOENERGETICS IN XENOBIOTIC-INFLAMMATION STEATOSIS. J. Teodoro, A. P. Rolo, P. J. Oliveira INTERACTIONS. F. F. Tukov1, J. F. Maddox1, and C. M. Palmeira. Center for Neurosciences and D. E. Amacher2, R. A. Roth1 and P. E. Ganey1. Cell Biology, Department of Zoology, University of 1Pharmacology & Toxicology, Michigan State Coimbra, Coimbra, Portugal. University, East Lansing, MI and 2Safety Sciences #1714 MITOCHONDRIAL ANTIOXIDANT Groton, Pfizer Inc., Groton, CT. STATUS AND NUCLEOSIDE REVERSE #1719 SUPPRESSION OF NITRIC OXIDE TRANSCRIPTASE INHIBITOR (NRTI) PRODUCTION AND INDUCIBLE NITRIC ASSOCIATED TOXICITY. H. Leitner1, 2 and B. OXIDE SYNTHASE EXPRESSION BY Day2, 1. 1Toxicology, UCHSC, SOP, Denver, CO and NATURALLY OCCURRING SMALL 2Medicine, NJMRC, Denver, CO. MOLECULES IN LPS-STIMULATED #1715 GOVERNING GLOBAL MITOCHONDRIAL RAW264.7 CELLS. S. Yea1, 2, C. Choi1, 2, D. Seog1 FUNCTION THROUGH REGULATION OF and Y. Park1. 1Department of Biochemistry, College VOLTAGE-DEPENDENT ANION CHANNELS of Medicine, Inje University, Busan, Korea, South (VDAC): IMPLICATIONS FOR PHYSIOLOGY Korea and 2Biohealth Product Research Center, Inje AND TOXICOLOGY. J. J. Lemasters and E. L. University, Busan, Korea, South Korea. Sponsor: H. Holmuhamedov. Cell & Developmental Biology, Kim. University of North Carolina at ChapelHill, Chapel #1720 INHIBITION OF LIPOPOLYSACCHARIDE Hill, NC. STIMULATED PHAGOCYTIC ACTIVITY #1716 MITOCHONDRIAL F1-ATP SYNTHASE: OF RAT PERITONEAL MACROPHAGES BY NO FUNCTIONAL CONSEQUENCES METHYL PAMITATE. S. sarkar, M. Khan, B. S. OF RNA INTERFERENCE-MEDIATED Khaphalia and S. G. Ansari. Pathology, University of GENE SILENCING IN HEPG2. C. Strupp1, F. Texas of Medical Branch, Galveston, TX. Straube1, O. Grenet1, W. E. Trommer2 and A. Wolf1. #1721 IN VITRO PRO-INFLAMMATORY EFFECTS 1Biomarker Development, Novartis Pharma AG, OF NICOTINE AND A TOBACCO-SPECIFIC Basel, Switzerland and 2Department of Chemistry, NITROSAMINE ON HUMAN LUNG University of Kaiserslautern, Kaiserslautern, ALVEOLAR CELL LINE A549 AND HUMAN Germany. MACROPHAGE CELL LINE U937. S. F. Yee #1717 MITOCHIP: AN OLIGONUCLEOTIDE and R. D. Leverette. Lorillard Tobacco Company, MICROARRAY AS A GENOMIC TOOL Greensboro, NC. TO UNDERSTAND NRTI-INDUCED #1722 IN VITRO INHIBITION OF SUBSTANCE P MITOCHONDRIAL DYSFUNCTION IN THE ON IL-1 RELEASE FROM ALVEOAR CELLS MOUSE LIVER. V. Desai1, C. L. Moland1, W. IN RESPONSE TO JP-8 JET FUEL. N. N. Sun, S. Branham1, T. Lee2, R. R. Delongchamp2, J. E. C. Nardi, S. S. Wong and M. L. Witten. Pediatrics, Leakey3 and J. C. Fuscoe1. 1Center for Functional University of Arizona, Tucson, AZ. Genomics, Division of Systems Toxicology, NCTR, Jefferson, AR, 2Division of Biometry and Risk #1723 IN VITRO TOXICOLOGY OF ALUMINUM Assessment, NCTR, Jefferson, AR and 3Office of NANOPARTICLES IN RAT LUNG Scientific Co-ordination, NCTR, Jefferson, AR. MACROPHAGES. A. J. Wagner1, 2, S. Hussain2, K. Hess3, C. Bleckmann1, E. England1 and J. J. Schlager2. 1Air Force Institue of Technology, Wright-Patterson AFB, OH, 2Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH and 3Geo-Center Inc., Wright-Patterson AFB, OH. WEDNESDAY up-to-date information at www.toxicology.org 197 , 1 , , 1 Key Key , A. J. A. J. , 1 1 . 3 . INSERM
T. T. T. and T. ) 2 J. R. Piccotti J. Biology, Biology, 1 . Worldwide Safety Worldwide 3 3 M. Y. Farooqui Y. M. H. V. Ratajczak V. H. . Annual Meeting Annual Australian Water Water Australian 2 th D. L. Morris , D. 1 Worldwide Safety Sciences, Safety Sciences, Worldwide and K. O’Halloran 2 2 STUDIES. Pathology, University of Texas Texas of University Pathology, 3 SOT's 45 SOT's and A. E. Ahmed A. E. and 2 Worldwide Safety Sciences, Pfizer Safety Sciences, Worldwide 1 , R. M. Slim . 1 3 , C. Haskard 1 CENTOX, Landcare Research, Lincoln, New Lincoln, New Landcare Research, CENTOX, 3
Pharmacology and Toxicology, Al-Azhar University, Al-Azhar University, Toxicology, and Pharmacology J. D. Alvey D. J. Kawabata Centre for Toxicology, RMIT-University, Bundoora, RMIT-University, Toxicology, Centre for Australia, VIC, Melbourne, University of Texas Pan American, Edinburg, TX, American, Edinburg, Pan Texas of University and S. Jayadev. Toxicology, Toxicology, and S. Jayadev. Jin, K. Blanchard B. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT. DEPENDENT T-CELL A OF VALIDATION RESPONSE IN CYNOMOLGUS ANTIBODY MONKEYS (INDONESIAN ORIGIN) USING (KLH). J. KEYHOLE LIMPET HEMOCYANIN A. Kirk and Cristiano, S. Rouleau, N. De Gagne, N. Laboratory Sciences, L. LeSauteur. Immunology, Laboratories Preclinical Montréal, Charles River QC, Canada. Senneville, and Di Marco Zealand. Sponsor: P. OF INTER-ANIMAL EVALUATION DEPENDENT T-CELL THE IN VARIABILITY RESPONSE IN RATS. ANTIBODY ASSESS IMMUNE COMPETENCE TO ANTIBODY OF BY PRODUCTION KEYHOLE LIMPET HEMOCYANIN ADMINISTRATION ORAL FOLLOWING OF CYCLOPHOSPHAMIDE. S. Kerdine-Roemer, D. Antonios, A. Antonios, D. WITH NISO4. S. Kerdine-Roemer, Lecoeuche and M. Pallardy Larange, D. VITRO CELLS - IN 2 Cairo, Egypt and PEELI COD (MACCULLOCHELLA HEAD KIDNEY CELL FUNCTIONS BY Wright F. P. CYLINDROSPERMOPSIN. Harford Pfizer Inc., Chesterfield, MO and Medical Branch, Galveston, TX. Medical Branch, Galveston, MURRAY OF IMMUNOMODULATION IL-12 PRODUCTION BY DCS ACTIVATED ACTIVATED BY DCS IL-12 PRODUCTION Sciences, Pfizer Inc., Groton, CT. OF OPTIMUM DETERMINATION TO NEEDED NUMBER OF RATS Inc., Ann Arbor, MI, Arbor, Ann Inc., A. R. Abd-Allah A. R. UMR-S 461, Faculty of Pharmacy, Chatenay- of Pharmacy, UMR-S 461, Faculty France. Malabry, OF POTENTIAL IMMUNOTOXIC HUMAN LEUKOCYTES IN ACRYLONITRILE HUMAN COLONIC EPITHELIAL T84 AND Quality Centre, Bolivar, Adelaide, SA, Australia Adelaide, SA, Quality Centre, Bolivar,
(Continued) Annual Annual th Wednesday, March 8 March Wednesday, #1739 9:00 AM to 12:00 NOON 9:00 Exhibit Hall METHODS IN IMMUNOTOXICITY POSTER SESSION: CT and Lynne Groton, Pfizer, Thomas Kawabata, Chairperson(s): QC, Canada. CTBR, Senneville, LeSauteur, AM–12:00 NOON 9:00 Displayed: AM–12:00 NOON Attended: 10:30 #1737 #1736 #1734 #1738 #1735 45 198 . Meeting & ToxExpo & Meeting
C. E. S. , C. 2, 1 , E. S. E.
N. E. and N. N. E. Kaminski and N. , S. S. Barve 1 C. E. Sulentic Pharmacology & Pharmacology
1 . 1 D. H. , S. Bissonnette and D. D. Shnaider D. W. Chang W. AGONIST, INDUCES AGONIST, γ . Microbiology and S. Bloom. Microbiology B. L. Kaplan B. . and T. S. Chen and T. J. Schlezinger J. 2 . Microbiology and . Microbiology E. Muscarella and D. B MOTIFS WITHIN THE 3’ IgH THE 3’ WITHIN κB MOTIFS Medicine, University of Louisville, Louisville, Medicine, University 2 . Pharmacology & Toxicology, Toxicology, & C. E. Sulentic. Pharmacology REGULATORY REGION. REGULATORY CALCIUM-DEPENDENT MAP KINASE CALCIUM-DEPENDENT MAP KINASE IN PRO/PRE- APOPTOSIS AND ACTIVATION Wright State University, Dayton, OH. Dayton, Wright State University, A PPAR GW7845, C. Pelsue, D. Swett, A. Curtis and C. Sczymczuk. Swett, D. C. Pelsue, & Environmental Toxicology Maine Center of ME. of Southern Maine, Portland, Health, University J. McClain J. MODULATION OF THE 3’ THE 3’ OF MODULATION CHAIN HEAVY IMMUNOGLOBULIN BY REACTIVE REGION REGULATORY C. Ranatunga D. Romer, SPECIES. E. J. OXYGEN and Toxicology, University of Louisville, Louisville, KY University Toxicology, . Pharmacology & Toxicology, Wright State Toxicology, & Sulentic. Pharmacology OH. Dayton, University, THE OF CHARACTERIZATION OF ACTIVITY IMMUNOSUPPRESSIVE CANNABINOID, THE PLANT-DERIVED CANNABIDIOL. . Center for Integrative Toxicology and Toxicology Kaminski. Center for Integrative Toxicology, the Department and of Pharmacology East Lansing, MI. State University, Michigan THE DRE AT INTERACTIONS PROTEIN AND CHANGES IN MARKERS OF B CELL DIFFERENTIATION. . Environmental Health, Boston University Health, Boston University Sherr. Environmental Health, Boston, MA. School of Public DRUG OF BCL-2-MEDIATED BYPASS DERIVED A NEWLY IN RESISTANCE CELL LINE. HUMAN B-LYMPHOID Bloom and B CELLS. ARSENIC IDUCED GROWTH ARREST AND ARREST ARSENIC IDUCED GROWTH LINES. IN MOUSE B CELL APOPTOSIS Wise Sponsor: J. J. Romer and D. C. Ranatunga. Pharmacology & Pharmacology C. Ranatunga. Romer and D. J. OH. Dayton, Wright State University, Toxicology, THE 3’IgH REGULATORY OF MODULATION DIVERSE REGION BY STRUCTURALLY AHR THE ACTIVATE THAT CHEMICALS A. Henseler and R. PATHWAY. SIGNALING D. Muscarella D. Immunology, Cornell University, Ithaca, NY. Cornell University, Immunology, ADHESION OF HUMAN B- DIFFERENTIAL FOLLICULAR DENDRITIC TO CELL LINES MODULATION AND SUBSEQUENT CELLS APOPTOSIS. INDUCED OF CHEMICALLY KY. Immunology, Cornell University, Ithaca, NY. Cornell University, Immunology, TCDD ON LPS-INDUCED EFFECTS OF Center for Integrative Toxicology and Department Toxicology Center for Integrative State Michigan Toxicology, and of Pharmacology East Lansing, MI. University, PREVENTS 4-HYDROXYNONENAL- BETAIN T IN CD4+ INDUCED CYTOTOXICITY LYMPHOCYTES. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1726 #1725 #1732 #1730 #1727 #1724 #1731
#1728 Program Description Description Program #1729 #1733
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1740 A VALIDATION STUDY OF AN IN VIVO #1749 DISTINCTIVE GENE EXPRESSION DELAYED-TYPE HYPERSENSITIVITY PATTERNS IN THYMUSES EXPOSED TO (DTH) MODEL IN RHESUS MONKEYS. C. ATROPHY-INDUCING CHEMICALS. K. M. Satterwhite1, C. M. Brodmerkel2, K. Vaddi2, Nohara1, K. Ao1, Y. Miyamoto1, C. Tohyama2, T. L. E. Black1 and P. B. Lappin1. 1Charles River Kobayashi1, H. Sato3 and T. Ito1. 1National Institute Laboratories, Preclinical Services, Sparks, NV and for Environmental Studies, Tsukuba, Japan, 2Incyte Corporation, Wilmington, DE. 2CDBIM, University of Tokyo, Tokyo, Japan and 3IMMD, Tokyo, Japan. #1741 OPTIMIZATION OF AN IN VITRO NATURAL KILLER (NK) CELL ACTIVITY ASSAY IN #1750 GENE EXPRESSION ALTERATIONS IN CYNOMOLGUS MONKEYS. E. Rechetnik, C. IMMUNE SYSTEM PATHWAYS FOLLOWING M. Satterwhite, L. E. Black and P. B. Lappin. Charles EXPOSURE TO IMMUNOSUPPRESSIVE River Laboratories, Preclinical Services, Sparks, NV. CHEMICALS. R. Patterson1, N. Walker1, K. White, Jr.2, R. Brown2, D. Musgrove2, S. Harrison1 and D. #1742 ASSESSMENT OF NK CELL ACTIVITY Germolec1. 1NIEHS, Research Triangle Park, NC IN THE RAT USING FLOW CYTOMETRY. and 2Virginia Commonwealth University, Richmond, 1 1 1 F. Condevaux , J. Guichard , F. Horand and J. VA. Descotes2. 1MDS Pharma Services, St Germain s/ L’Arbresle, France and 2Poison Center, Lyon, France. Wednesday, March 8 #1743 ANALYTICAL VALIDATION 9:00 AM to 12:00 NOON OF A PERIPHERAL BLOOD Exhibit Hall IMMUNOPHENOTYPING ASSAY FOR RATS. R. Caldwell, J. Fishel and P. Marshall. Toxicology, POSTER SESSION: NEUROTOXICITY: METALS—MANGANESE Covance Laboratories, Madison, WI. Chairperson(s): Donald Smith, University of California - Santa Cruz, #1744 BIOMARKERS FOR DRUG-INDUCED Santa Cruz, CA and Ronald Tjalkens, Colorado State University, Fort STRESS: CORTICOSTERONE-INDUCED Collins, CO. CHANGES IN GENE EXPRESSION IN WHOLE BLOOD. P. Hebert1, S. B. Pruett1, M. Displayed: 9:00 AM–12:00 NOON Lawton2, J. Lapointe2 and K. T. Thomas2. 1Cellular BIology & Anatomy, LSU Health Sciences Center, Attended: 9:00 AM–10:30 AM 2 Shreveport, LA and Safety Sciences, Pfizer, Inc., #1751 OLFACTORY TRANSPORT OF MANGANESE Groton, CT. TO THE BRAIN IS ENHANCED BY ANEMIA #1745 MEASUREMENT OF EX VIVO CYTOKINE AND INVOLVES DIVALENT METAL 1, 2 2 RELEASE BY HUMAN AND CYNOMOLGUS TRANSPORTER-1. K. Thompson , R. Molina , 2 2 1 MONKEY WHOLE BLOOD CULTURES T. Donaghey , J. Brain and M. Wessling-Resnick . 1 USING CYTOKINE BEAD ARRAYS. M. Wing, Genetics and Complex Diseases, Harvard School 2 D. Lanham, A. Michel and S. Watts. Experimental of Public Health, Boston, MA and Environmental Biology, Huntingdon Life Sciences Ltd., Cambs, Health, Harvard School of Public Health, Boston, United Kingdom. Sponsor: D. Steve. MA. #1746 EVALUATION OF DRUG-INDUCED #1752 TISSUE DISTRIBUTION OF MANGANESE ALTERATIONS IN LYMPHOID TISSUES IN IRON SUFFICIENT OR IRON DEFICIENT BY LASER SCANNING CYTOMETRY. J. A. RATS AFTER STAINLESS STEEL WELDING- 1 2 Wijsman, L. A. Obert, J. R. Piccotti, R. E. Guzman FUME EXPOSURE. J. D. Park , E. S. Park , K. Y. 1 1 1 3 and R. W. Dunstan. Safety Sciences Michigan, Kim , D. W. Kim , S. J. Choi , Y. H. Chung , J. H. 3 3 3 3 1 Pfizer, Ann Arbor, MI. Sung , J. H. Han , J. S. Lee and I. J. Yu . Preventive Medicine, Chung-Ang University, Seoul, South #1747 CRYO TISSUE MICRO ARRAYS – A NOVEL Korea, 2Pathology, Chung-Ang University, Seoul, APPROACH TO HIGH THROUGHPUT South Korea and 3Laboratory of Occupational THERAPEUTIC BIOPHARMACEUTICAL Toxicology, Chemical Safety & Health Research SCREENING. A. Postoyalko. Covance Laboratories Center, Occupational Safety & Health Research Ltd., Harrogate, United Kingdom. Sponsor: D. Institute, KOSHA, Daejeon, South Korea. Everett. #1753 EFFECT OF DOPAMINE TRANSPORTER #1748 VALIDATION OF A SEMI-QUANTITATIVE BLOCKADE ON DIETARY IRON/ BIOASSAY WITH AN ELISA ENDPOINT MANGANESE INTERACTIONS IN THE FOR THE DETECTION OF NEUTRALIZING DEVELOPING MALE RAT BRAIN. K. Erikson ANTI-PROTEIN-X ANTIBODIES IN HUMAN and J. Anderson. Nutrition, The University of North SERUM. G. Pinard1, M. Poirier1, B. Ruelland1, Carolina Greensboro, Greensboro, NC. H. Harouchi1, L. LeSauteur1, D. Finco-Kent2, X. Guo2 and T. Kawabata2. 1Immunology Laboratory Sciences, Charles River Laboratories Preclinical Montréal, Senneville, QC, Canada and 2Safety Sciences, Immunotoxicology Laboratory, Pfizer Global R&D, Groton, CT. WEDNESDAY up-to-date information at www.toxicology.org 199 .
M. R. A. , J. , J. V. , V. D. and D. 1 Department 3 College of College and 2 3 and and Biology, Texas Texas Biology, 3 1 3 C. Au C. C. J. Choi C. J. R. Gwiazda Annual Meeting Annual , R. Nass A. G. Kanthasamy and A. G. 2 th , M. Zoran 2 R. R. Reams
SOT's 45 SOT's College Of Pharmacy, Florida Of Pharmacy, College 1 K. M. Erikson Integrative Biosciences, Texas A&M Texas Biosciences, Integrative . Environmental and Radiological and Radiological Environmental 2 1 , 1 2 , A. Kanthasamy . viaBILITY. 1 Center of Molecular Neuroscience, 1 , R. Mouneimne Department of Pediatrics, Vanderbilt Vanderbilt Department of Pediatrics, . 1 4 4 Department of Nutrition, University of North Department of Nutrition, University Vanderbilt University Med. Ctr., Nashville, TN, TN, Nashville, Med. Ctr., University Vanderbilt Anantharam A&M University, Tallahassee, FL and Tallahassee, A&M University, Aschner P. Stephenson P. 2 Carolina-Greensboro, Greensboro, NC, TN and Crooks EXPOSURE. M. Braun-Sommargren, D. Toxicology, R. Smith. Environmental and D. of California, Santa Cruz,University CA. OF NEONATAL NEUROTOXICITY PERSISTENCE MANGANESE EXPOSURE: TO AND SUSCEPTIBILITY OF EFFECTS C. Kern, AGENTS. OTHER UCSC, Santa Cruz, CA. Smith. ETOX, METALS EFFECT OF DIVALENT AND CADMIUM ON MANGANESE FUNCTION UBIQUITIN-PROTEASOME IN CELL AGGREGATION AND PROTEIN MODELS OF PRION DISEASE: CULTURE IN PRION OF METALS POSSIBLE ROLE DISEASE PATHOGENESIS. IA. A&M University, College Station, TX. Station, College A&M University, AND PB/MN METAL MN EFFECT OF PB, HIPPOCAMPAL MIXTURES ON RAT NEURON EFFECTS OF MANGANESE CHLORIDE METAL ON 3 ISOFORMS OF DIVALENT IN KNOCKOUTS TRANSPORTER CAENORHABDITIS ELEGANS. of Anaesthesiology, Vanderbilt University, Nashville, University, Vanderbilt Anaesthesiology, of Biomedical Sciences, Iowa State University, Ames, State University, Biomedical Sciences, Iowa B. Mohl B. B. Tjalkens B. MANGANESE SUPPRESSES THE MANGANESE SUPPRESSES INTERCELLULAR OF PROPAGATION ASTROCYTE IN WAVES CALCIUM OF ALTERATION THROUGH NETWORKS DYNAMICS. CALCIUM MITOCHONDRIAL G. Anderson G. University Med. Ctr., Nashville, TN. Nashville, Med. Ctr., University TRANSFERRIN RECEPTOR OF DISRUPTION LEVEL MANGANESE BY LOW PROCESSING University, College Station, TX and Station, College University, FL. Tallahassee, University, A&M Florida Pharmacy, Health Sciences, Colorado State University, Ft. State University, Health Sciences, Colorado Collins, CO.,
(Continued) Annual Annual th #1765 #1766 #1762 #1761 #1764 #1763 45 , 200 1
Meeting & ToxExpo & Meeting 2 J. , J. 2 , , 3 1 N. and N. 2, 4, , A. , 1 B- Texas A&M Texas 2 Colorado κ 1 D. Milatovic , D. , D. S. Miller S. , D. 1 . 1 , D. J. Volsky J. , D. 1 2 1 INTEGRIN Pediatrics, Pediatrics, Pediatrics, Pediatrics, K. M. Erikson 1 β 2 , . 3 , C. Lan Pharmacology, Pharmacology, 1 4 Environmental Health Environmental 1 1, 3, 4 P. L. Crittenden P. . . X. Wang X. 1 M. Aschner and M. 1 NIH/NIEHS, Research 2 V. A. Fitsanakis V. , G. Bentsman 1 The Kennedy Center, Vanderbilt Vanderbilt Center, The Kennedy 4 S. M. Mense R. B. Tjalkens and R. B. 2 Health Sciences, Purdue University, University, Health Sciences, Purdue , J. G. Anderson G. , J. 1 2 . 1 and L. Zhang M. Aschner and M. 1 , M. J. Avison , M. J. R. B. Liu and R. B. W. A. Buffington , J. 2 . CEHS, Basic Sciences, Mississippi State X. Liu , M. Zhou 1, 5 1 , 1 Nutrition, University of North Carolina- Nutrition, University Hopkinsville, KY, State University, Murray Kennedy Ctr, Vanderbilt University Med. Ctr, Med. Ctr, University Vanderbilt Ctr, Kennedy 3 2 5 Radiology, Vanderbilt University Institute of University Vanderbilt Radiology, 1 Pharmacology, Vanderbilt University Med. Ctr, Med. Ctr, University Vanderbilt Pharmacology, Columbia University, Division, Virology Molecular . University Med. Ctr, Nashville, TN. Nashville, Med. Ctr, University THE ALTERS MN SELECTIVELY A SUBSET OF GENES LIKE EXPRESSION OF THOSE ENCODING PROINFLAMMATORY HUMAN FUNCTIONS IN PRIMARY ASTROCYTES. Vanderbilt University Med. Ctr, Nashville, Med. Ctr, University Vanderbilt TN, Triangle Park, NC. Park, Triangle OF BRAIN MANGANESE DETERMINATION USING MAGNETIC ACCUMULATION ATOMIC AND (MRI) IMAGING RESONANCE Zhang N. ABSORPTION SPECTROSCOPY. Imaging Science, Nashville, TN, TN, Imaging Science, Nashville, Sciences, Columbia University, New York and York New Sciences, Columbia University, Vanderbilt University Medical Center, Nashville, Medical Center, University Vanderbilt TN, University, Mississippi State, MS. Mississippi State, University, NF MANGANESE POTENTIATES DEPENDENT EXPRESSION OF INOS OF ACTIVATION THROUGH AND ERK. Health and Radiological Tjalkens. Environmental Ft. Collins, CO. Sciences, Colorado State University, AND OVEREXPRESSION ASTROGLIOSIS SYNTHASE OF INDUCIBLE NITRIC OXIDE WITH NEURONAL (NOS2) CORRELATE A MOUSE MODEL OF IN INJURY A. K. MANGANESE NEUROTOXICITY. Sullivan TIME COURSE OF P38-ALPHA IN N9 MICROGLIAL PHOSPHORYLATION TO EXPOSURE CELLS FOLLOWING VITRO MANGANESE IN Nashville, TN and Nashville, Sengupta 2 York. New R. C. Gupta 3 Greensboro, Greensboro, NC, and 5 SUBCELLULAR REDISTRIBUTION OF IRON IRON OF SUBCELLULAR REDISTRIBUTION (IRE)-CONTAINING RESPONSE ELEMENT CHOROID RAT IN INTACT TRANSPORTERS TO EXPOSURE PLEXUS FOLLOWING Fe. INORGANIC Mn OR Zheng and W. State University, Fort Collins, CO and Fort State University, University, College Station, TX. Station, College University, J. C. Gore J. H. Graziano M. Filipov Nashville, TN. Nashville, AND IMPAIRED STRESS OXIDATIVE AFTER EXPOSURE ENERGY METABOLISM MANGANESE. TO V. A. Fitsanakis V. Vanderbilt University Med. Ctr, Nashville, TN Nashville, Med. Ctr, University Vanderbilt West Lafayette, IN and IN Lafayette, West 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1754 Program Description Description Program #1756
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1767 EFFECTIVE TREATMENT OF MANGANESE- #1772 ZINC ATTENUATES CADMIUM-INDUCED INDUCED OCCUPATIONAL PARKINSONISM MODULATION OF CHOLINE TRANSPORT WITH P-AMINOSALICYLIC ACID (PAS-NA): IN CULTURED CHOROID PLEXUS. A. R. A CASE OF 17-YEAR FOLLOW-UP STUDY. Villalobos and J. Tay. University of Rochester, Y. Jiang1, X. Mo2, F. Du2, H. Gao3, J. Xie4, F. Lia4, Rochester, NY. E. Pira5 and W. Zheng6. 1Department Occup Health Toxicol, Guangxi Medical University, Nanning, #1773 BRAIN TRANSPORT AND DISTRIBUTION Guangxi, China, 2Department of Neurology, OF COPPER AS AFFECTED BY SYSTEMIC 1 2 1 Guangxi Medical University, Nanning, Guangxi, IRON STATUS. B. Choi and W. Zheng . College China, 3Wuzhou Center for Disease Prevention of Medicine, Chung-Ang University, Seoul, South 2 and Control, Wuzhou, Guangxi, China, 4Wuzhou Korea and School of Health Sciences, Purdue Worker’s Hospital, Wuzhou, Guangxi, China, University, West Lafayette, IN. 5 Department of T.O. & Occup Health, University of #1774 THE EFFECTS OF CUPRIC 6 Turin, Turin, Italy and School of Health Sciences, DIMETHYLDITHIOCARBAMATE ON Purdue University, West Lafayette, IN. MATERNAL AND FETAL LONG-EVANS RATS. B. Scharf1 and L. D. Trombetta2, 1. 1Biological Wednesday, March 8 Sciences, St. John’s University, New York and 9:00 AM to 12:00 NOON 2Pharmaceutical Sciences, St. John’s University, Exhibit Hall Jamaica, NY. #1775 METHYLMERCURY ALTERS GLUTAMINE POSTER SESSION: NEUROTOXICITY: METALS—GENERAL HOMEOSTASIS IN ASTROCYTES. M. Aschner1, 1 2 3 1 Chairperson(s): Stephen Lasley, Universtiy of Illinois, Peoria, IL and Z. Yin , O. Soldin and T. Syversen . Pediatrics, Ginger Moser, U.S. EPA, Research Triangle Park, NC. Vanderbilt University Medical Center, Nashville, TN, 2Medicine, Georgetown University, Washington, Displayed: 9:00 AM–12:00 NOON DC and 3Clinical Neuroscience, Norwegian University of Science and Technology, Trondheim, Attended: 10:30 AM–12:00 NOON Norway. #1768 GENDER DIFFERENCES IN #1776 METHYLMERCURY EXPOSURE IN VITRO AUTOANTIBODIES TO NERVOUS INCREASES SOLUBLE gp130 RECEPTOR, A SYSTEM PROTEINS RESULTING FROM MODULATORY FACTOR OF IL-6 FUNCTION, OCCUPATIONAL EXPOSURES TO LEAD OR IN ORGANOTYPIC CULTURES OF MOUSE 1 2 MERCURY. N. M. El-Fawal , A. M. Musa , M. CEREBELLUM. D. Arias-Salvatierra1, L. C. 2 1 1 Y. Shamy and H. N. El-Fawal . Neurotoxicology Acosta-Saavedra1, P. C. Conde-Moo1, E. K. Laboratory, Mercy College, Dobbs Ferry, NY and Silbergeld2 and E. S. Calderon-Aranda1. 1Toxicology, 2 Institute of Public Health, University of Alexandria, Cinvestav, Mexico, DF, Mexico and 2Bloomberg Alexandria, Egypt. Sponsor: J. O’Callaghan. School of Public Health, Johns Hopkins University, #1769 DIMETHYLARSENIC IS THE MOST Baltimore, MD. ABUNDANT ARSENITE METABOLITE IN #1777 MULTIPLE SOURCES MAY CONTRIBUTE 1 1 MOUSE BRAIN. J. H. Limon , M. E. Gonsebatt , TO METHYLMERCURY-INDUCED 5 3 V. M. Rodriguez , E. Uribe-Querol , G. Gutierrez- INCREASES IN [CA2+] IN RAT CEREBELLAR 3 4 2 I Ospina , M. Giordano , L. C. Sanchez-Pena and SLICES. Y. Yuan and W. D. Atchison. Pharml/ 2 1 L. M. Del Razo . Med. Genomica y Toxicology Toxicology, Mich State University East Lansing, MI. Ambiental, Inst. de Invest Biomedicas, UNAM, Mexico, DF, Mexico, 2Seccion de Toxicologia, #1778 EFFECTS OF ACTIVATION AND CINVESTAV, Mexico, DF, Mexico, 3Biologia INHIBITION OF GROUP I METABOTROPIC Celular y Fisiologia, Inst. de Invest Biomedicas, GLUTAMATE RECEPTOR 1 SUBTYPE IN UNAM, Mexico, DF, Mexico, 4Inst. de METHYLMERCURY-INDUCED CALCIUM Neurobiologia, UNAM, Queretaro, Qro, Mexico DYSREGULATION OF RAT CEREBELLAR and 5Environmental and Comunity Medicine, The GRANULE CELLS. A. Segarra-Arroyo2, 1, D. University of Medicine and Dentistry of New Jersey K. Atchison1 and W. D. Atchison1. 1Department and Rutgers, Piscataway, NJ. Pharmacology/Toxicology, Mich State University East Lansing, MI and 2Research Initiative for #1770 MERCURY AND SELENIUM IN BRAIN Student Enhancement, University of Puerto Rico at AND BLOOD AFTER CHRONIC, LOW- Cayey, Cayey, Puerto Rico. LEVEL METHYLMERCURY EXPOSURE. M. C. Newland and M. Reed. Psychology, Auburn #1779 EFFECTS OF METHYLMERCURY (MEHG)
University, Auburn, AL. ON GABAA RECEPTOR-MEDIATED CURRENTS IN HEK-293 CELLS ARE NOT #1771 LEAD ALTERS THE ABILITY OF THE ALTERED BY THE PRESENCE OF THE α6 CHOROID PLEXUS (CP) TO SEQUESTER SUBUNIT. C. J. Herden1, R. K. Hajela2, 1, Y. Yuan2 BETA-AMYLOID FROM CEREBROSPINAL and W. D. Atchison2, 1. 1Neurosci. Progrm, Michigan FLUID (CSF). J. S. Crossgrove and W. Zheng. State University, East Lansing, MI and 2Department School of Health Sciences, Purdue University, West of Pharmacology/Toxicology, Michigan State Lafayette, IN. University, East Lansing, MI. WEDNESDAY up-to-date information at www.toxicology.org 201 . .
and 1 , 1 R. , K. 2 J. E. , J. Biological Biological , S. 1 2 Biochemistry, Biochemistry, 3 . 1 J. E. Johnson , J. 2 Annual Meeting Annual th Natural Sciences and 1 , M. C. Vemuri , M. C. . 1 3 , P. Lahsaei , P. 2 . and L. C. Wang. Wang. and L. C. S. M. Lasley A. Giddabasappa and G. W. Gross W. and G. 2 SOT's 45 SOT's . , D. D. Savage and Savage D. Martinez, D. E. J. , M. H. Ellisman 2 , J. Brown , J. 2 C. S. Chetty
University of Houston, Houston, TX and of Houston, Houston, University 1 and C. Suresh . 1 1 Department of Surgery, Childrens’ Hospital of Childrens’ Department of Surgery, Departments of Anatomy and Neuroscience, Anatomy Departments of 2 2 University of California, CA. San Diego, University EVALUATION OF ZINC TOXICITY USING TOXICITY OF ZINC EVALUATION ON CULTURED NETWORKS NEURONAL M. Parviz ARRAYS. MICROELECTRODE Ghassemzadeh 2 and Shafer TX. Sponsor: T. ARSENIC PERINATAL MODERATE MARKERS OF EXPOSURE ELEVATES IN NEUROTRANSMISSION SEROTONERGIC OF FORMATION DORSAL HIPPOCAMPAL MICE. ADULT Campbell GA, and PA Philadelphia, Philadelphia, Pradesh, India. OF CA2+-INDEPENDENT, MODULATION FROM PB2+-INDUCED EXOCYTOSIS II. CELLS BY CAM KINASE PC12 RAT LEAD REDUCES ELECTRICALLY CHRONIC BRAIN- HIPPOCAMPAL STIMULATED FACTOR DERIVED NEUROTROPHIC (BDNF) RELEASE. Mathematics, Savannah State University, Savannah, Savannah, State University, Mathematics, Savannah A. Fox D. Chen and Q. Xiao, S. Chaney, W. , Johnson A. Fox D. G. A. Perkins G. TX Denton, Texas, of North Sciences, University Biomedical & Therapeutic Sciences, University of Therapeutic Sciences, University Biomedical & IL. of Medicine, Peoria, Illinois College LEAD EXPOSURE GESTATIONAL AND INCREASES SWITCHES CELL FATE OF RETINAL PROLIFERATION CELLS IN DEVELOPING PROGENITOR MOUSE RETINA. C. J. Fredrickson C. J. The University of Texas Medical School, Galveston, Medical School, Galveston, Texas of The University National Institute of India, Hyderabad, Andhra Hyderabad, National Institute of India, Cellular and Molecular Vijverberg. and H. Westerink Sciences Assessment Institute for Risk Toxicology, Utrecht, Netherlands. Sponsor: - Utrecht University, M. van den Berg TX. Houston, University.Houston, PROTECTS BCL-XL OVEREXPRESSION SYNAPTIC PHOTORECEPTOR ROD LEAD- FROM MITOCHONDRIA TERMINAL TRANSITION. INDUCED PERMEABILITY A. M. Allan. University of New Mexico School of Mexico of New Allan. University A. M. NM. Albuquerque, Medicine, IN MOUSE ALUMIUM OF NEUROTOXICITY S. Ko, J. Yum, Y. S. Kim, M. Hwang, BRAIN. Jang. General Kim and D. Kim, C. Song, J. Kim, J. Toxicological National Instititue of Toxicology, Chung Sponsor: J. Research, Seoul, South Korea. NEUROTOXIC EFFECTS OF LEAD ON EFFECTS OF LEAD NEUROTOXIC CELLS IN HUMAN NEUROBLASTOMA CULTURE.
(Continued) Annual Annual th #1792 #1793 #1788 #1789 #1790 #1791 #1794 #1787 45 202
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1 , T. and T. E. 2 2, 3 . , B. , B. 2 R. Nass , 4, 2 Neuroscience 3 1 . and M. 1 3 , A. Litterman , 1 , S. Hong and Pharmacology, Pharmacology, 2 K. R. Reuhl M. Aschner , M.
1 Pharmacology & Pharmacology X. Yu , X. 2 , K. Loveless T. Syversen , T. 1, 2 3 , E. Smith 1 , B. Buckley , B. M. Aschner and M. 2 3 Department of Pharmacology, Department of Pharmacology, 1 . . Veterinary Veterinary Abbott. and L. C. , L. Evje , M. E. Miller, Thuett, M. E. Miller, A. K. 4, 1, 2 , X. Zhou R. Nass E. J. Gribble E. J. 1, 2 1 Department of Pediatrics, Vanderbilt Vanderbilt Department of Pediatrics, Department of Pediatrics, Vanderbilt Vanderbilt Department of Pediatrics, , G. C. Jiang G. Department of Genetics, Rutgers 4 2 2 and E. DiCicco-Bloom 1 Department of Neuroscience, Norwegian DepartmentNorwegian of Neuroscience, 2 . 1 A. Halladay 1 . , Pediatrics, Vanderbilt University, Nashville, University, Vanderbilt Pediatrics, 1 1 4 Center in Molecular Toxicology, Vanderbilt Vanderbilt Toxicology, Center in Molecular 2 Department of Neuromedicine, Norwegian Department of Neuromedicine, Norwegian Forest Wake and Pharmacology, Physiology Nashville, University, Vanderbilt Anesthesiology, Pharmacology & Toxicology, Rutgers University, Rutgers University, Toxicology, & Pharmacology EOHSI, Rutgers University, Piscataway, NJ. Piscataway, EOHSI, Rutgers University, Vanderbilt University, Nashville, TN, TN, Nashville, University, Vanderbilt Syversen Konsolaki 1 3 TN and 3 Trondheim, Technology, of Science and University and Norway URANIUM. McLaughlin NC, Winston-Salem, University, M. Aschner and M. Piscataway, NJ. Piscataway, FOR P53 IN MOUSE MIDBRAIN A ROLE NEURAL PRECURSOR CELL (NPC) CELL AND PREMATURE ARREST CYCLE DIFFERENTIATION NEURONAL METHYLMERCURY FOLLOWING EXPOSURE. . Department of Environmental E. M. Faustman of and Occupational Health Sciences, University WA. Seattle, Washington, ON THE EFFECT OF ETHYL MERCURY AND METALLOTHIONEIN-2 WILDTYPE CAENORHABDITIS ELEGANS. KNOCKOUT ORGANOMERCURIC COMPOUNDS IN NEUROGENESIS ALTER SELECTIVELY A. HIPPOCAMPUS. RAT THE NEONATAL Falluel-Morel K. R. Reuhl 2 MERCURY COMPOUNDS AFFECT COMPOUNDS MERCURY MOLECULAR SYSTEMS INTRACELLULAR AND CELLULAR MORPHOLOGY OF SH- SY5Y CELLS. TX. 3 DIFFERENTIAL VULNERABILITY OF DIFFERENTIAL AND CEREBELLAR NEURONS CORTICAL INDUCED METHYLMERCURY TOWARDS Kaur P. NEUROTOXICITY. Tiffany-Castiglioni & Cell Biology, UMDNJ, Piscataway, NJ and Piscataway, UMDNJ, & Cell Biology, University Medical Center, Nashville, TN. Nashville, Medical Center, University STUDIES OF DEPLETED NEUROTOXICITY K. J. Helmcke K. J. Integrative Biosciences, Texas A&M University, A&M University, Texas Biosciences, Integrative Station, College Medicine, Veterinary of College Toxicology, Rutgers University, Piscataway, NJ and Piscataway, Rutgers University, Toxicology, University Medical Center, Nashville, TN. Nashville, Center, Medical University PEPTIDES ALZHEIMER BETA-AMYLOID TOXICITY METHYLMERCURY MODERATE DROSOPHILA. YOUNG IN University Medical Center, Nashville, TN, TN, Nashville, Medical Center, University TN. University, Piscataway, NJ, NJ, Piscataway, University, University of Science and Technology, Trondheim, Trondheim, Technology, Science and of University and Norway Vanderbilt University Medical Center, Nashville, Medical Center, University Vanderbilt TN, T. Gangi T. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1781 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1795 STRIATAL CFOS EXPRESSION DURING Wednesday, March 8 POSTNATAL DEVELOPMENT IN THE 9:00 AM to 12:00 NOON RAT: EFFECTS OF INORGANIC LEAD Exhibit Hall (PB) EXPOSURE AND AMPHETAMINE CHALLENGE. Q. Cai and D. K. Pitts. POSTER SESSION: P450 EXPRESSION AND REGULATION Pharmaceutical Sciences, Wayne State University, Detroit, MI. Chairperson(s): Roger Couloumbe, Utah State University, Logan, UT and Juan Hernandez, University Texas at El Paso, El Paso, TX. #1796 C-FOS EXPRESSION IS DIFFERENTIALLY ACTIVATED BY METHYLMERCURIC Displayed: 9:00 AM–12:00 NOON CHLORIDE AND PSYCHOGENIC STRESSORS IN THE MURINE BRAIN. J. F. Attended: 9:00 AM–10:30 AM Cooper. Toxicology, Rutgers University/ UMDNJ, #1803 INDUCTIVE EFFECT OF PYRIDAZINE Piscataway, NJ. (PZ) ON CYTOCHROME P4502E1 #1797 PROTEOMIC ANALYSIS OF PB2+ EXPOSURE (CYP2E1) ALTERS THE METABOLISM OF ON PROTEINS IN THE AUDITORY TRICHLOROETHYLENE (TCE). S. Lee, C. BRAINSTEM. J. Prins and D. I. Lurie. Biomedical A. White, S. Muralidhara, S. S. Anand and J. V. and Pharmaceutical Sciences and Center for Bruckner. Department of Pharmaceutical and Environmental Health Sciences, University of Biomedical Sciences/Interdisciplinary Program in Montana, Missoula, MT. Sponsor: A. Holian. Toxicology, University of Georgia, Athens, GA. #1798 EFFECT OF SUBCHRONIC ARSENITE #1804 TERTIARY AMYL METHYL ETHER EXPOSURE ON SENSORY SURAL NERVES (TAME) INCREASES HEPATIC TOXICITY OF RATS. E. Garcia-Chavez1, B. Segura2, H. PARAMETERS AND ALTERS XENOBIOTIC Merchant3, L. C. Sanchez-Pena1, I. Jimenez4 and METABOLIZING ACTIVITY IN HEPATIC L. M. Del Razo1. 1Toxicology, Cinvestav, Mexico AND RESPIRATORY TISSUES FOLLOWING D.F., Mexico, 2FES-Iztacala, UNAM, Mexico D.F., AN ACUTE ORAL EXPOSURE. J. L. Weissert Mexico, 3IIB-UNAM, Mexico D.F., Mexico and and R. A. Schatz. Toxicology, Northeastern 4Physiology & Biophysics, Cinvestav, Mexico D.F., University, Boston, MA. Mexico. #1805 MECHANISM OF INACTIVATION IN HUMAN #1799 NEUROTOXICITY EVALUATION OF CYP2A6 GENETIC VARIANTS CYP2A6*2 DIBUTYLTIN IN ADULT RATS. V. C. Moser, P. AND CYP2A6*5. K. George1, X. He1, W. Hu1 and M. Phillips and K. L. McDaniel. NTD/NHEERL, J. Hong1, 2. 1Joint program in Toxicology, Rutgers U.S. EPA, Research Triangle Park, NC. University and UMDNJ, Piscataway, NJ and 2School of Public health/Environmental and Occupational #1800 STRESS AND DEPLETED URANIUM Health Sciences Institute, University of Medicine EXPOSURE ALTER HIPPOCAMPAL and Dentistry of New Jersey, Piscataway, NJ. DENDRITIC MORPHOLOGY IN THE RAT. R. F. Mervis1, 4, D. S. Barber2, M. Ehrich3, S. Hancock3, #1806 EFFECT OF AGE AND GENDER ON IN J. Hinckley3, J. Kotick1, 5, M. Shah1, T. Amato5 and B. VITRO S-MEPHENYTOIN HYDROXYLASE S. Jortner3. 1Neurostructural Research Laboratories, ACTIVITY AND CYTOCHROME 2C19 Tampa, FL, 2Center for Environmental and Human PROTEIN EXPRESSION. S. M. Bandiera, Toxicology, University of Florida, Gainesville, FL, A. Mirfazaelian and J. Sebelova. Faculty of 3Laboratory for Neurotoxicity Studies, Virginia Pharmaceutical Sciences, University of British Tech, Blacksburg, VA, 4Center for Aging & Brain Columbia, Vancouver, BC, Canada. Repair, University of South Florida, Tampa, FL and #1807 CYP1A1-GFP TRANSGENIC MOUSE 5The Honors College, University of South Florida, MODEL: FLUORESCENT BIOMARKER Tampa, FL. OF TOXICANT EXPOSURE. T. N. Operana1, #1801 NEUROLOGICAL EFFECTS OF CHRONIC 2, N. Nguyen1, 2, S. Chen1, 2, D. Beaton1, 2 and R. H. URANIUM AND STRESS EXPOSURE. D. Tukey1, 2. 1Pharmacology, University of California, S. Barber1, S. K. Hancock2, J. Hinckley2, K. San Diego, La Jolla, CA and 2Chemistry & Zimmerman3, M. F. Ehrich2 and B. S. Jortner2. Biochemistry, University of California, San Diego, 1Center for Environmental and Human Toxicology, La Jolla, CA. University of Florida, Gainesville, FL, 2Laboratory #1808 EVALUATION OF A RAPID ASSESSMENT for Neurotoxicity Studies, Virginia Tech, FOR MEASURING ENZYMATIC P450 Blacksburg, VA and 3Biomedical Science, Virginia ACTIVITY IN THE IMMORTALIZED HUMAN Tech, Blacksburg, VA. HEPATOCYTE CELL LINE FA2N-4. R. de #1802 LONG-TERM BEHAVIORAL Guzman2, L. D. Marroquin1, A. de Peyster2, G. CONSEQUENCES OF MATERNAL LEAD Stevens1 and Y. Will1. 1Safety Sciences, Pfizer, San (PB) AND STRESS: PREFERENTIAL Diego, CA and 2Graduate School of Public Health, VULNERABILITY OF FEMALES. M. Virgolini, San Diego State University, San Diego, CA. D. D. Weston, R. Lisek, M. Thiruchelvam and D. A. Cory-Slechta. Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, UMDNJ, Piscataway, NJ. WEDNESDAY up-to-date information at www.toxicology.org 203
, 1, 1 and M. W. , W. 1 C. and , D. Lee , D. , V. V. , 1 , M. 1 Department 1 1 . 1 , K. Muthiah, L. ]PYRENE IN Environmental Environmental 1 , I. Jun 1 . Department of E. M. Stagliola 2 INDUCTION Annual Meeting Annual , J. Wang-Buhler , J. 1, 3, 4 1 ). G. E. Corley-Smith th College of Pharmacy, of Pharmacy, College 1 , G. Kim . 1 1 , M. A. Martinez , M. A. Anadon and A. 1 1 , E. Brooks SOT's 45 SOT's 1 Center for Genome Research and Center for Genome Research , S. Lee 2 1 D. R. Buhler and D. , M. J. Diaz , M. J. , J. del Pino , J. 1 T. Jeong and T. 1 2 1, 4 , T. Jeon T. , 1 Marine and Freshwater Biomedical Science Marine and Freshwater 3 B. Mahadevan , B. Oregon Health Sciences Center, Environmental Gwangju, Chosun University, of Pharmacy, College ASSAYS WITH CLINICAL INDUCTION. ASSAYS and Molecular Toxicology, Oregon State University, State University, Oregon Toxicology, and Molecular OR, Corvallis, OR. Corvallis, State University, AROMATIC EFFECTS OF SIX POLYCYCLIC OF ACTIVITIES ON HYDROCARBONS CYTOCHROME AND PULMONARY HEPATIC RATS. P450S IN MALE SPRAGUE-DAWLEY South Korea. OF CYP1A2 GENE DISRUPTION 3-METHYLCHOLANTHRENE- MODULATES OF HEPATIC REGULATION MEDIATED CYP1A1 EXPRESSION IN AND PULMONARY , P. Chan, Y. Tsai and C. Wei. Institute of Wei. Tsai and C. Y. Chan, Ueng, P. T. Taipei, University, Taiwan National Toxicology, Taiwan. THE HEPATIC ON EFFECT OF FIPRONIL P450 CYTOCHROME MICROSOMAL M. Baird . Toxicology, CINVESTAV-IPN, Mexico Mexico CINVESTAV-IPN, Toxicology, E. Cebrián. Mexico. D.F., City, ETHER THE EFFECT OF DIISOPROPYL P450 ISOZYMES (DIPE) ON CYTOCHROME AND HEPATIC IN RESPIRATORY AND SUB-ACUTE ACUTE AFTER TISSUES EXPOSURE. INHALATION Boston, MA. W. Jiang, S. R. Kondraganti W. MICE. Abbott Laboratories, . Waring F. A. Blomme and J. IL. Abbott Park, P450 1A1, INDUCTION OF CYTOCHROMES LIVER BY BITERTANOL. AND 3A IN RAT 2B ENZYMES. M. R. Martinez-Larranaga Caballero EFFECT OF DDT ON EXPRESSION P450 IN CYTOCHROME OF HEPATIC A. Garcia-Jimenez, RATS. OVARIECTOMIZED L. M. Lopez-Gonzalez, A. Sierra-Santoyo ZEBRAFISH (Danio rerio 2 OR, 4 C. Jin 2 of Toxicology and Pharmacology, Complutense and Pharmacology, Toxicology of Spain and Madrid, University, . Pediatrics, Baylor College of College Baylor . Pediatrics, Moorthy and B. Wang TX. Medicine, Houston, A CYP3A4 INDUCTION DATABASE VITRO IN CORRELATING Northeastern University, Toxicology, . A. Schatz R. Center, Oregon State University, Corvallis, OR and Corvallis, University, State Oregon Center, and South Korea Gyeongsan, University, Yeungnam Healan-Greenberg, E. L. Feucht, B. P. Murray, E. Murray, P. B. E. L. Feucht, Healan-Greenberg, H. Jeong Toxicology and Pharmacology, Complutense and Pharmacology, Toxicology Spain. Madrid, University, INDUCTION OF CYTOCHROME P450 1A ON P450 1A ON INDUCTION OF CYTOCHROME L DIBENZO[A, TO EXPOSURE Biocomputing, Oregon State University, Corvallis, Corvallis, State University, Biocomputing, Oregon Martinez
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Nihon College College 2 2 , F. , F. D. and D. 1 2 B. and B. Pathology, Pathology, 2 3 , Y. Hwang Y. , Pharmacy, Pharmacy, , J. E. Salinas , J. , J. H. Tracy H. , J. 1 2 1 1, 2 . K. Gross- T. P. P. H. Dong, T. GENETICS, 1, 2 , S. Derkenne 2 1 University of of University 1 . National Cancer , M. Bermudez de 1 , R. Barrios 3 1 1 , K. Oh H. G. Shertzer , H. G. Pharmaceutics, 1 1, 2 2 , K. E. Thummel , K. E. 3 , B. Cisneros , B. 3 SECRETARIA DE SALUD, DE SALUD, SECRETARIA 4 , P. L. Stapelton , P. 2 T. P. Dalton P. , T. and H. Jeong , W. Jiang W. , 2 3 , J. Kim , J. Pathology, The Methodist Pathology, 1 2 TOXICOLOGY, CINVESTAV- TOXICOLOGY, 1 1, 2 . 1 M. L. Miller , 1 , S. C. Strom D. W. Nebert W. and D. , C. Zhu College of Pharmacy, Yeungnam Yeungnam of Pharmacy, College 1 3 Env. Occup. Health Sciences, University Occup. Health Sciences, University Env. Pediatrics, Baylor College of Medicine, College Baylor Pediatrics, 1 , E. Lee 3 ]PYRENE-INDUCED DISEASE. ]PYRENE-INDUCED , Y. Wei Y. , , S. Uno 1 1 3 and W. Jiang. Pediatrics, Jiang. Pediatrics, W. and , S. Kondraganti 1 1 , L. Wang, K. Muthiah, Wang, , L. Moorthy B. a . . E. Han 1 1 . University of Cincinnati of Nebert. University W. and D. , O. Zapata-Perez , O. 2 MARINE SCIENCES, CINVESTAV-IPN, Merida, MARINE SCIENCES, CINVESTAV-IPN, T. Jeong , T. CINVESTAV-IPN, Sabinas, Coahuila, Mexico. Sabinas, Coahuila, CINVESTAV-IPN, OF CYP3A4 IN DOWN-REGULATION AND HEPATOCYTES HUMAN PRIMARY CARCINOMA HUMAN LS180 COLORECTAL Hospital, Houston, TX. Hospital, Houston, 7-O-METHYLATED 5, 3, 4’, EFFECTS OF 3’, ARYL THE ON EPICATECHIN AND CYP 1A1 RECEPTOR HYDROCARBON University Washington, Seattle, WA and WA Seattle, Washington, University Washington, Seattle, WA, WA, Seattle, Washington, Moorthy Chosun University, Kwangju, South Korea, South Korea, Kwangju, Chosun University, Houston, TX and Houston, Medical Center, Cincinnati, OH. Medical Center, AND INTESTINE CYP1A1 IN LIVER WHILE CYP1B1 IN IMMUNE PROTECTS, IN ORAL CELLS POTENTIATES, J. Gonzalez J. T. Bammler T. Couroucli Baylor College of Medicine, Houston, TX. of Medicine, Houston, College Baylor OF OXYGEN-INDUCED ATTENUATION IN RATS ABNORMAL LUNG MATURATION POSSIBLE ROLE ACID: BY RETINOIC P4501A ENZYMES. OF CYTOCHROME C. P. Curran C. P. CELLS BY SULFORAPHANE. L. Eaton 3 and Mexico Yucatan, Steinmeyer F. Castorena-Torres CELLS. F. Leon Albores and A. IN MCF-7 HUMAN BREAST CARCINOMA IN MCF-7 HUMAN BREAST CARCINOMA CELLS. 2 for Proteineous Research Center of Pharmacy, South Kwangju, Materials, Chosun University, and Korea South Korea. Kyungsan, University, OF GENE ANALYSIS COMPARATIVE AROMATIC EXPRESSION BY POLYCYCLIC THREE HUMAN IN HYDROCARBONS A549 AND JURKAT HEPG2, CELL LINES: BENZO[ CHARACTERIZATION OF KNOCK-IN MICE CHARACTERIZATION ORGANELLE- EXPRESSING SUBCELLULAR SPECIFIC CYP1A1 PROTEIN. Dalton University, Tokyo, Japan and Tokyo, University, Couroucli N. Dragin N. University Pittsburgh, Pittsburgh, PA. Pittsburgh, Pittsburgh, University CINVESTAV-IPN, Mexico City, D.F., Mexico, Mexico, D.F., City, Mexico CINVESTAV-IPN, IPN, Mexico City, D.F., Mexico, Mexico, D.F., City, Mexico IPN, Institute, Bethesda, MD. THE GENE FOR MICE LACKING P450 (CYP)1A1 CYTOCHROME DIFFERENTIAL OR 1A2 DISPLAY LUNG HYPEROXIC TO SUSCEPTIBILITIES INJURY. Cincinnati Medical Center, Cincinnati, OH, Cincinnati Medical Center, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1809 Program Description Description Program #1811
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1824 BUTHIONINE SULFOXIMINE (BSO) #1832 CLONING, EXPRESSION AND PARTIAL MODULATES CYP1A ACTIVITY. M. E. CHARACTERIZATION OF A NOVEL Gonsebatt, G. Zamora and J. Espinosa Aguirre. CYTOCHROME P450 FROM TURKEY LIVER Medicina Genomica y Toxicologia Ambiental, THAT CATALYZES EPOXIDATION OF Instituto de Investigaciones Biomedicas, UNAM, AFLATOXIN B1. R. A. Coulombe and S. S. Yip. Mexico, DF, Mexico. Graduate Toxicology Program and Department of Veterinary Sciences, Utah State University, Logan, #1825 EFFECTS OF DIELDRIN AND UT. PHENOBARBITAL ON THE LEVELS OF MESSENGER RNA OF TOXICOLOGICALLY #1833 GENERATION AND CHARACTERIZATION IMPORTANT GENES. M. Dail1, 2, S. Burgess2, OF A CYP2A13 TRANSGENIC MOUSE 1, M. K. Ross1, 2 and J. Chambers1, 2. 1Center for MODEL. Y. Wei1, 2, X. Zhou1, 2, G. Ling1, X. Environmental Health, Mississippi State, Mississippi Zhang1, J. D’Agostino1, 2, J. Gu1, K. Kluetzman1, 2 State, MS and 2Basic Science, Mississippi State, and X. Ding1, 2. 1Wadsworth Center, New York State Mississippi State, MS. Department of Health, Albany, NY and 2School of Public Health, State University of New York at #1826 COMPARATIVE STUDY OF THE EFFECTS Albany, Albany, NY. OF SPIRONOLACTONE, PREGNENOLONE 16 ALPHA-CARBONITRILE AND #1834 ZEBRAFISH CYTOCHROME P450 3C1: DEXAMETHASONE ON MOUSE HEPATIC CLONING, DEVELOPMENTAL EXPRESSION, DRUG METABOLIZING AND OTHER PHYLOGENETIC AND IN SILICO GENE CHEMOPROTECTIVE ENZYMES. M. R. ANALYSIS. J. Wang-Buhler1, H. Tseng4, C. Hu4, Franklin and W. M. El Sayed. Pharmacology and H. Su4, G. E. Corley-Smith1 and D. R. Buhler1, 2, 3. Toxicology, University of Utah, Salt Lake City, UT. 1Environment & Molec. Toxicology, Oregon State University, Corvallis, OR, 2Marine and Freshwater #1827 ACTIVATION OF PREGNANE X RECEPTOR Biomedical Sciences Center, Oregon State (PXR) AND CONSTITUTIVE ANDROSTANE University, Corvallis, OR, 3Environmental Health RECEPTOR (CAR) BY OCTAMETHYLCYCL Sciences Center, Oregon State University, Corvallis, OTETRASILOXANE (D4) AND DECAMETHY OR and 4Institute of Bioscience and Biotechnology, LCYCLOPENTASILOXANE (D5) IN VITRO. P. National Taiwan Ocean University, Keelung, Taiwan. A. Jean1, J. A. Arthurton1, L. You2 and K. P. Plotzke1. 1Dow Corning Corporation, Midland, MI and 2CIIT, #1835 FUNCTIONAL CHARACTERIZATION OF Research Triangle Park, NC. HUMAN AND MOUSE CYTOCHROME P450 2S1 PROTEINS USING A BACTERIAL #1828 ST. JOHN’S WORT REDUCES RECOMBINANT EXPRESSION SYSTEM. P. TRIBROMOETHANOL-INDUCED SLEEP H. Bui1, 2 and O. Hankinson1, 2, 3. 1UCLA Molecular TIMES IN SXR TRANSGENIC MICE. S. E. Toxicology I.D.P., University of California-Los Lacher, L. M. Oko, A. C. Protain, H. J. Protain, C. Angeles, Los Angeles, CA, 2Pathology and S. Gardiner and G. DeKrey. School of Biological Laboratoty Medicine, University of California- Sciences, University of Northern Colorado, Greeley, Los Angeles, Los Angeles, CA and 3Molecular CO. Biology Institute, and Johsson Comprehensive #1829 INDUCTION OF HEPATIC ENZYME Cancer Center, David Geffen School of Medicine, EXPRESSION BY P-NONYLPHENOL (NP)IS University of California-Los Angeles, Los Angeles, MODULATED BY DIET IN MALE SPRAGUE- CA. DAWLEY RATS. X. Fu, S. M. Cooper and K. B. Delclos. National Center for Toxicological Research, Wednesday, March 8 Jefferson, AR. 9:45 AM to 10:45 AM Room 11A #1830 NONYLPHENOL INDUCES P450S IN A GENDER-SPECIFIC MANNER. J. P. Hernandez, INFORMATIONAL SESSION: CREATE BIBLIOGRAPHIES L. M. Chapman, X. C. Kretschmer and W. S. INSTANTLY WITH ENDNOTE AND DISCOVER NEW Baldwin. Biological Sciences, University of Texas at REFERENCE TOOLS El Paso, El Paso, TX. #1831 14-WEEK ORAL TOXICITY Presented by Thomson ResearchSoft STUDIES OF KAVA IN F344 RATS: EndNote is used by millions of scientists worldwide to organize refer- IMMUNOHISTOCHEMICAL ANALYSIS OF ence literature and create bibliographies instantly. Learn about EndNote EXPRESSIONS OF HEPATIC CYTOCHROME 9 and three new software products that simplify research and publishing: N. P. Clayton1, K. Yoshizawa2, G. Kissling1, P450. Onfolio™—organize Web pages and synchronize reference data with P. Chan1, L. T. Burka1 and A. Nyska1. 1NIEHS, EndNote, RefViz™—explore references visually, and sciPROOF™— Research Triangle Park, NC and 2Astellas Pharma, streamline scientific proofreading. Osaka, Japan. WEDNESDAY up-to-date information at www.toxicology.org 205 - - Annual Meeting Annual th SOT's 45 SOT's Sciences toxicity parameters for drug discovery for drug parameters discovery toxicity in vitro
(Continued) Annual Annual th 12:15 PM to 1:15 PM Room 11A IN INTEGRATED ADVANCES SESSION: INFORMATIONAL ANALYSIS MICROARRAY Agilent by Presented An Agilent sponsored event on advances other in emerging genemicroarray expressionapplications includingprofiling, aCGH, The talks will as ChiP-on-Chip, as include proteomic splice analysis, well analysis. variant discussions on Agilent’s higher densityformats and integration applications. of data sets from multiple microarray microarrays, multi-array slide 8 March Wednesday, 1:30 PM to 2:30 PM Room 11B ADME/ BD GENTEST™ NOVEL SESSION: INFORMATIONAL TOXICITY AND TECHNOLOGIES FOR METABOLISM TOX BD Biosciences by Presented BD Biosciences is providing a the large range of reagents, leaderplastic consumables, instruments, and in ADME/Toxcontract research services. have recently We developed several novel tech products and services 1:30 PM to 2:30 PM Room 11A USING HISTOLOGICAL SESSION: INFORMATIONAL CORNEA THE BOVINE ENHANCE TO EVALUATION FOR OCULAR ASSAY AND PERMEABILITY (BCOP) OPACITY IRRITATION Vitro In Institute for by Presented 12:00 NOON to 1:30 PM Room 6D AN SESSION: THE DIRECTORS MEET SPECIAL SESSION: AGENCIES GOVERNMENT AT ACTIVITIES OF UPDATE Institute of Environmental National A. Schwartz, : David Speakers EPA, U.S. Gray, NC; George Park, Triangle Health Sciences, Research Bethesda, National Cancer Institute, Barker, Anna D. DC; and Washington, MD. In this session, leaders of several major federal agencies will engage in a panel discussion of emerging trends in research toxicology and its funding. Attendees will gain a better understanding of research the activ toxicology Wednesday, March 8 March Wednesday, The BCOP is used widely to assess ocular Although irritation.the standard end points are generally predictive, damage caused through certain modes of action is sometimes missed. Histological evaluation aids predictions by allowing direct measure of depth and area of and injury, a characterization of the specific lesions induced. nologies to study and predict nologies and development. Products include BD Gentest™ BD GentestSM TransporterContract Research Services, BD Gentest™ Serum Systems,Binding test kits. biomarker and toxicity System, BD Gentest Hepatocytes, 8 March Wednesday, ities sponsored by the agencies, will hear about changes of new direction initiatives concerning Speakers and will toxicology. identify opportunities where non-agency toxicologists may be able to participate in initiatives of questions of attendees. their agencies and will answer 8 March Wednesday, 45 - - - - 206 Meeting & ToxExpo & Meeting in vitro hemato and www.toxicology.org in the Exhibit
45th Annual Meeting and ToxExpo and Meeting Annual 45th Anniversary Celebration, SOT will be giving away a total th
Anniversary Raffle Contest will be held in the Exhibit Hall th Wednesday Afternoon Wednesday
ANNIVERSARY RAFFLE CONTEST ANNIVERSARY TH of $4500 over of a $4500 period! three-day over More details and contest rules are on the SOT Annual Meeting Web site at SOT 45 11:00 AM to 12:00 NOON 11:00 9:45 AM to 10:45 AM AM to 10:45 9:45 AM to 12:00 NOON 11:00 Hall on-site. Exhibit Hall 45 Wednesday, March 8 March Wednesday, 12:00 NOON to 1:30 PM kines. Room 11B FUTURE OF THE SESSION: INFORMATIONAL TESTING HEMATOPOIETIC Inc. Technologies, StemCell by Presented Bone marrow CFU assays are currently the standard for Room 11A OF IN-LIFE INTEGRATION SESSION: INFORMATIONAL TOXICOGENOMICS WITH PARAMETERS Gene Logic by Presented A case study example of mechanistic analysis using cardiac gene expres Room 11B OF ROLE EXPANDING SESSION: INFORMATIONAL TOXICOLOGY IN TELEMETRY International Data Sciences by Presented Advances in implantable technology and computerized data collection and safety pharmacology, physiology, in applications new enabled have analysis This session will the review traditional assessment applica and toxicology. Wednesday, March 8 March Wednesday, Program Description Description Program Monday, Tuesday, and Wednesday between 12:00 NOON and Wednesday and 1:30 As PM. Tuesday, Monday, part of the 45 Wednesday, March 8 March Wednesday, sion data integrated with classical in-life parameters indicative of cardiac toxicity. Examples will be given of how the compoundanalysis comparisons,can includeand cross-identify prognostic and diagnosticof toxicity, markersi.e., those precedent and coincident respectively. with classical measures, poietic testing and utilized in late drug toxicity will screening. We discuss miniaturization of the assay amenable for potential implementation automationin late to discovery/early pre-clinical allow phase. Discussion will follow addressing various assays designed for screening potential cyto Wednesday, March 8 March Wednesday, tion of telemetry to research as well as cover recent application and product product and application recent cover as telemetryof tion well as research to Toxicology. facilitating applications in developments
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 Wednesday, March 8 1:30 PM to 4:30 PM 1:30 PM to 4:30 PM Room 6E Room 6A
SYMPOSIUM SESSION: THE BASES FOR INTER-INDIVIDUAL SYMPOSIUM SESSION: DETERMINANTS OF MANGANESE DIFFERENCES IN SUSCEPTIBILITY TO ALLERGIC DISEASE NEUROTOXICITY: FROM WORMS TO MAN
Chairperson(s): G. Frank Gerberick, Procter & Gamble Company, Chairperson(s): Tomas Guilarte, Johns Hopkins University, Baltimore, MD Cincinnati, OH. and Michael Aschner, Vanderbilt University Medical Center, Nashville, TN.
Endorsed by: Endorsed by: Immunotoxicology SS* Neurotoxicology SS* Mechanisms SS Allergy is a diverse family of diseases that continues to provide important Metals SS and substantial challenges for toxicology and occupational and environ- Occupational and Public Health SS mental medicine. Skin sensitization, resulting in allergic contact dermatitis, represents the most common manifestation of immunotoxicity in humans, Manganese is essential for normal physiological function in humans. and the prevalence of atopic allergy has increased significantly in the However, occupational or environmental exposures to excess levels of USA and Europe. In recent years there have been impressive advances manganese are associated with adverse effects on the central nervous made in the identification and characterization of chemicals and proteins system. Human exposure to manganese varies depending on geographical that have the potential to cause allergic sensitization, and in the develop- location, urban or rural environment, diet, and importantly, occupational ment of improved approaches to risk assessment. However, there remains settings. Furthermore, acute or chronic exposure to different chemical considerable uncertainty about the factors that determine well-documented forms of manganese may occur at different life-stages. These factors along inter-individual differences in susceptibility to chemical and protein allergy. with diverse genetic composition are likely to impart differential sensitivity The purpose of this Symposium is to review new and emerging informa- of individuals to manganese neurotoxicity. This symposium is meant to tion on the cellular and molecular mechanisms responsible for heritable identify the contribution of modifiers such as age, nutritional status and and acquired differences in susceptibility to allergic diseases. genetics, to the vulnerability of individuals to manganese neurotoxicity. #1836 1:30 THE BASES FOR INTER-INDIVIDUAL Speakers will detail advantages offered by invertebrate animal models in DIFFERENCES IN SUSCEPTIBILITY TO deciphering the mechanisms and genetics of manganese neurotoxicity. The ALLERGIC DISEASE. I. Kimber1 and F. role of diet in particular iron deficiency will be discussed in relation to Gerberick2. 1Syngenta, Macclesfield, United manganese transport into cultured brain endothelial cells and regional brain Kingdom and 2Procter & Gamble, Cincinatti, OH. distribution. Behavioral, neuroimaging and pathological endpoints will be described in a non-human primate model of chronic manganese exposure. #1837 1:35 CHEMICAL AND PROTEIN ALLERGY: These studies are prospective in nature and follow in parallel the effects of IMMUNOLOGICAL MECHANISMS AND manganese exposure on cognitive and motor function and neurochemical CLINICAL CHARACTERISTICS. I. Kimber. changes in the living brain. Finally, biomarkers for the human diagnosis of Syngenta, Macclesfield, United Kingdom. early manganese exposure will be highlighted. The multidisciplinary nature of the symposium, bringing together scientists with expertise in behav- #1838 2:10 HERITABLE AND ACQUIRED FACTORS ioral, molecular, brain imaging and human population studies, is aimed at INFLUENCING SUSCEPTIBILITY TO providing a comprehensive state-of-the-art account of recent advances in ALLERGIC CONTACT DERMATITIS. G. the fast-paced research area on manganese neurotoxicity. Gerberick. Procter & Gamble, Cincinnati, OH. #1842 1:30 DETERMINANTS OF MANGANESE #1839 2:45 HERITABLE AND ACQUIRED FACTORS NEUROTOXICITY: FROM WORMS TO MEN. INFLUENCING SUSCEPTIBILITY TO T. R. Guilarte1 and M. Aschner2. 1Envir Health CHEMICAL RESPIRATORY ALLERGY. S. M. Sciences, Johns Hopkins Public Health, Baltimore, Tarlo1, 2. 1Medicine, University of Toronto, Toronto, MD and 2Pediatrics, Vanderbilt University, ON, Canada and 2Medicine, Respiratory Division, Nashville, TN. Toronto Western Hospital, Toronto, ON, Canada. Sponsor: I. Kimber. #1843 1:35 MANGANESE-INDUCED DOPAMINE NEURODEGENERATION IN C. ELEGANS: #1840 3:20 CHEMICAL POLLUTION, GENETIC PHARMACOGENETIC ANALYSIS IN A FACTORS AND THE CHANGING NOVEL MODEL OF MANGANISM. R. M. PREVALENCE OF ATOPIC ALLERGY AND Nass1, 2, M. Fullard1, 2, K. Fallen1, 2, J. Andresen1, 2, ASTHMA. B. Nemery2 and I. Kimber1. 1Syngenta, C. McManus1, 2 and M. Marvanova1, 2. 1Department, Macclesfield, United Kingdom and 2Laboratory of Anesthesiology, Vanderbilt University Medical of Pneumology, K.Universtiy of. Leuven, Leuven, Center, Nashville, TN and 2Pharmacology, Belgium. Vanderbilt University Medical Center, Nashville, TN. #1841 3:55 FACTORS GOVERNING THE ACQUISITION OF FOOD ALLERGY. R. J. Dearman and I. #1844 2:10 DIETARY IRON MODULATES MANGANESE Kimber. Syngenta, Macclesfield, United Kingdom. NEUROTOXICITY. M. Aschner1, V. Fitsanakis1 and K. Erikson2. 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN and 2Department of Nutrition, University of North Carolina, Greensboro, NC. WEDNESDAY up-to-date information at www.toxicology.org 207 - - , 1
3 A.
G. G. J. J.
K. Driscoll Procter & Environmental Environmental 2 J. Carter , J. 2 J. R. Harkema J. 2 Annual Meeting Annual th A. Elder , 1 Centre of Expertise in Life Pathobiology, Michigan Michigan Pathobiology, 1 1 .
. 2 2 SOT's 45 SOT's J. Wagner , J. 1 J. Carter and J. 1 Procter & Gamble Co., Cincinnati, OH. Procter & Gamble 3 State University, East Lansing, MI, State University, . Central Product Safety, Procter & Gamble Procter & Gamble Carter. Central Product Safety, Co., Cincinnati, OH. OF INHALED POORLY TOXICITY NASAL AND EPITHELIAL SOLUBLE PARTICLES: INHALED TO RESPONSES INFLAMMATORY PARTICLES CARBON BLACK ULTRAFINE AIRWAYS. NASAL IN RODENT Oberdorster and G. and Sciences, Heerlen, Netherlands and . Environmental Medicine, University of Medicine, University Elder. Environmental NY. Rochester, Rochester, TOXICITY: MECHANISMS OF PSP AND SIZE. AREA SURFACE PARTICLE Mason, OH. Carter. Procter & Gamble, and J. THE OF A SPECIES COMPARISON THE MECHANISMS UNDERLYING OXIDANT/ANTIOXIDANT PULMONARY OF AFTER INHALATION RESPONSE (PSP). PARTICLES POORLY-SOLUBLE MECHANISMS OF LOW SOLUBILITY MECHANISMS OF LOW TUMORS. LUNG PARTICLE-INDUCED . Environmental Medicine, University of Medicine, University . Environmental Oberdorster NY. Rochester, Rochester, OF SPECIES A MECHANISTIC EVALUATION DIFFERENCES IN PARTICLE-INDUCED INFLAMMATION. PULMONARY P. Santhanam P. SOLUBLE OF POORLY INHALATION CANCER: AND LUNG PARTICLES P. ASSESSMENT. AND RISK PARADIGMS Borm Gamble, Cincinnati, OH. Gamble, Medicine, University of Rochester, Rochester, NY Rochester, of Rochester, Medicine, University
(Continued) Annual Annual th Risk Assessment SS Assessment Risk Mechanisms SS Regulatory and Safety Evaluation SS* Regulatory and Safety Evaluation Treatment related vascular injury is a significant pre-clinical safety issue for the pharmaceutical industry. Noninvasive methods for early detection in animal studies and for monitoring patientsthe humanto relevanceassess of inpre-clinical clinical findingstrials remain Thea vital observationunmet need. of vascular injurymay stopduring or toxicitydelay testingcompound clinicalin development animals,dose and/orrange, therebylimit limitingthe allowablethe development or the therapeu #1852 3:20 1:30 PM to 4:30 PM Room 6C ASSESSING HUMAN FOR THE PATH SYMPOSIUM SESSION: NEW SAFETY BIOMARKERS ADVANCING AND RELEVANCE INJURY VASCULAR FOR DRUG-INDUCED & Chairperson(s): Denise Robinson, Pfizer Global Research West & Co Inc., Merck Sistare, London, CT and Frank New Development, PA. Point, by: Endorsed #1849 1:50 #1851 2:50 tic uses of a product. The clinical advance of compounds that produce inhaled PSP. This data, in turn,inhaled PSP. significantly impacts the setting of interna standards for PSP. tional exposure #1848 1:30 #1850 2:20 #1853 3:50 Wednesday, March 8 March Wednesday, 45 - - 208 Meeting & ToxExpo & Meeting
W. W.
1 , E. , D. F. F. , D. , M. 1 1 2 and J. S. and J.
4 Biostatistics, 3 , P. Barker , P. Radiology, Johns Radiology, 2 2 , H. Emberger 1 , T. Syversen T. , Pathol Anat & Cell Biol, Pathol 3 5 J. L. McGlothan , J. 1 Pathol., Anatomy and Cell Anatomy Pathol., 1 . , A. Schultz , 2 1 , M. Alexander , M. M. Chen 2 , 1 Env Health Sciences, Johns Hopkins Health Sciences, Johns Hopkins Env 1 , C. A. Rohde , C. 2 . 5 , S. Fritz 1 , Y. Zhou Y. , 2 Neuroscience, Norwegian University Sciences Tech, Tech, Sciences University Neuroscience, Norwegian Environment Health Sciences., Johns Hopkins Environment . Purdue University, West Lafayette, IN. Lafayette, West Zheng. Purdue University, 4 and Norway Trondheim, MANGANESE EXPOSURE IN HUMANS. Schneider COGNITIVE AND MOTOR EFFECTS OF EFFECTS AND MOTOR COGNITIVE IN MANGANESE EXPOSURE CHRONIC Schneider J. NON-HUMAN PRIMATES. Decamp R. Guilarte and T. 2 Baltimore, MD. University, AND NEUROIMAGING CHANGES IN NEUROPATHOLOGICAL BRAIN THE NON-HUMAN PRIMATE MANGANESE EXPOSURE. FOLLOWING T. R. Guilarte T. Hopkins Medicine, Baltimore, MD, Health, Baltimore, MD, Johns Hopkins Public Degaonkar Public Health, Baltimore, MD, Health, Baltimore, MD, Public Thomas Jefferson University Philadelphia, PA. University Thomas Jefferson OF BIOMARKERS OF DISCOVERY Biol., Thomas Jefferson University, Phila., PA and Phila., PA University, Thomas Jefferson Biol., Wong
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Toxicologic and Exploratory Pathology SS* Pathology and Exploratory Toxicologic Although our understanding of the processes underlying the pathogenesis of particle-induced lung disease has the greatly over years, improved ques : Janet Carter, Procter & Gamble Company, Cincinnati, Company, & Gamble Procter Carter, Chairperson(s): Janet NY. Rochester, of Rochester, University Alison Elder, OH and by: Endorsed Wednesday, March 8 March Wednesday, 1:30 PM to 4:30 PM Room 1B SOLUBILITY MECHANISMS OF LOW SYMPOSIUM SESSION: TUMORS LUNG PARTICLE-INDUCED #1846 3:20 #1845 2:45
tions still remain regarding the issues of species to differences inhaledin responseparticles, the mechanismstheir underlyingimpact on thesehuman hazard differences, evaluation and andrisk Poorly-solubleassessment processes. particles (PSP)they are have low in several solubility, have low toxicity, commonand are non-genotoxic. non-mutageniccharacteristics: Numerous and inhalation studies in rodent species have conductedbeen to assess the dose-related toxicityblack, titanium dioxide, talc, of and coal theseand shale dusts). PSP Studies conducted (e.g. carbon in rats have demonstrated that chronic inhalation of materials results high in increased doses pulmonary ofinflammation, fibrosis,these epithelial hyperplasia, and, in some cases, adenomas and carcinomas in the periph eral rat This lung. response is generally referred to as response an overload or threshold effect. The hypothesis that a the threshold tumor effect response is inrelevant ratsto is supportedindicating by that data at from exposurenumerous levelsstudies inflammatorybelow that response,which causestumors aare persistentnot indicates produced.the involvement Substantialof secondarydata processes, also such andas inflammationinflammatory-induced oxidative stress, as the possible rat lung mechanismstumor response. Furthermore,for recent studies have highlighted the impact of particle size and surface area on these Along processes. with the effects observed in the lower respiratory tract, it has recently become apparent that nasal tissue is also an important target toxicity. for The particle-induced current information regarding the contributed has response in inflammation chronic and retention, tissue area, roles of particle surface to response tumor lung rat the of understanding mechanistic improved an to Program Description Description Program #1847 3:55
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) vascular injury pre-clinically has also been slowed by the lack of clear Wednesday, March 8 regulatory guidance. Sensitive and specific biomarkers as well as experi- 1:30 PM to 4:30 PM mental approaches that provide a better understanding of the mechanisms Room 5A that produce vascular injury in pre-clinical models, are needed to assess relevance for human risk, to manage the risk rationally, and ensure SYMPOSIUM SESSION: ROLE OF EPIGENETICS IN THE FETAL clinical trial safety. Just as important as the science is the process for BASIS OF ADULT DISEASE gaining scientific and regulatory acceptance around the validity and appropriate clinical investigative application of any such new biomark- Chairperson(s): Jerrold Heindel, NIEHS, Research Triangle Park, NC and ers. This session will highlight the latest advances in our mechanistic Retha Newbold, NIEHS, Research Triangle Park, NC. understanding of the pathways of vascular injury in various pre-clinical models, and introduce novel approaches to assessing and monitoring Endorsed by: vascular compromise. The focus will be on what we can do with what Carcinogenesis SS we know now, given the regulatory impetus to drive the qualification Mechanisms SS and application of new biomarker technologies for safety assessment. Molecular Biology SS Reproductive and Development SS* #1854 1:30 THE PATH FOR ASSESSING HUMAN RELEVANCE AND ADVANCING NEW There is increasing evidence that some environmental agents, especially SAFETY BIOMARKERS FOR DRUG those with endocrine agonist or antagonist activity, may alter develop- 1 INDUCED VASCULAR INJURY. D. Robinson mental programming via alteration in gene expression that do not result 2 1 and F. Sistare . Worldwide Safety Sciences, Pfizer, in malformations but in functional deficits. These functional deficits in 2 New London, CT and Laboratory Sciences and tissue potential are expressed later in life as increased susceptibility to Investigative Toxicology, Merck & Co., Inc., West disease/dysfunction. In some cases the functional deficits have been shown Point, PA. to be transmitted to the next generations(s). The mechanism proposed #1855 1:35 PATHWAYS FOR DAMAGE TO THE for this phenomenon, termed the fetal basis of adult disease, is believed VASCULATURE. J. R. Bender1 and B. Enerson2, to be epigenetic alterations in gene expression probably via altered DNA 1. 1Medicine, Yale University, new haven, CT and methylation. The talks in this session will highlight examples of in utero 2Pfizer Pharmaceuticals, Groton, CT. exposures resulting in increased diseases later in life. In some instances transgenerational effects due to in utero exposures to environmental agents #1856 2:05 DRUG-INDUCED VASCULITIS: FDA’S can be shown. An overview of epigenetics with an emphasis on how it PERSPECTIVE AND THE PATH FORWARD. might contribute to the adult diseaases and the transgenerational effects of T. Papoian and F. Goodsaid. U.S. Food and Drug these in utero exposures will also be presented. Administration, Rockville, MD. Sponsor: D. #1860 1:30 ROLE OF EPIGENETICS IN THE FETAL Robinson-Gravatt. BASIS OF ADULT DISEASE. J. J. heindel1, R. 1 1 2 4 #1857 2:40 NOVEL BIOMARKERS OF DRUG-INDUCED Newbold , T. K. Archer , M. Skinner , C. Walker and 3 1 VASCULAR INJURY. C. S. Louden1, D. R. Jirtle . NIEHS/NIH/DHHS, Research Triangle 2 Brott1, S. Gould1, A. Katein1, T. Kelley1 and Park, NC, Washington State University, Pullman, 3 4 H. Jones1. 1Safety Assessment, AstraZeneca WA, Duke University, Durham, NC and University Pharmaceuticals, Merside, Alderley Park, United of Texas MD Anderson Cancer Center, Smithville, Kingdom, 2Safety Assessment, Astrazeneca TX. 3 Pharmaceuticals, Wilmington DE, DE, Safety #1861 1:40 REGULATING THE GENOME WITH Assessment, Astrazeneca Pharmaceuticals, Merside, CHROMATIN AND EPIGENETIC CHANGES. 4 Alderley, United Kingdom, Safety Assessment, T. Archer. NIEHS/NIH, Research Triangle Park, NC. Astrazeneca Pharmaceuticals, Wilmington, DE, Sponsor: J. Heindel. 5Safety Assessment, Astrazeneca Pharmaceuticals, Wilmington DE, DE and 6Safety Assessment, #1862 2:30 EPIGENETIC TRANSGENERATIONAL Astrazeneca Pharmaceuticals, Merside, Alderley EFFECTS OF ENDOCRINE DISRUPTORS ON Park, United Kingdom. MALE FERTILITY AND OTHER DISEASES. M. Skinner. Washington State University, Pullman, #1858 3:00 TOWARD AN UNDERSTANDING OF WA. Sponsor: J. Heindel. DRUG-INDUCED VASCULAR INJURY: HISTOPATHOLOGICAL AND GENE #1863 3:10 DEVELOPMENTAL PROGRAMMING: EXPRESSION CORRELATES. R. D. Snyder1 and UNDERSTANDING HOW EARLY LIFE J. Zhang2. 1Investigative and Molecular Toxicology, ENVIRONMENTAL EXPOSURES Schering-Plough Research Institute, Lafayette, NJ DETERMINE CANCER INCIDENCE IN and 2CDER, USFDA, Silver Spring, MD. ADULTS. C. Walker. Carcinogenesis, MD Anderson Cancer Center, Smithville, TX. #1859 3:20 A SYSTEMS BIOLOGY APPROACH TO UNDERSTAND MECHANISMS OF DRUG- #1864 3:50 EPIGENETIC TARGETS LINKING INDUCED VASCULAR INJURY. E. Floyd1, PRENATAL NUTRITION WITH ADULT J. Pollard2, O. Beckonert1, S. Beushausen1, S. DISEASE SUSCEPTIBILITY. R. Jirtle. Duke Chevalier1, F. Clemo1, N. Dagues1, B. Duckworth2, University, Durham, NC. Sponsor: J. heindel. G. Hanton1, W. Ladd2, M. Neuberg2, V. Pawlowski1, D. Pratt2, M. Reily1, D. Robertson1, D. Robinson1, T. Slater1, C. Sobry1 and M. Lawton1. 1Pfizer, Inc., New London, CT and 2Genstruct, Inc., Cambridge, MA. WEDNESDAY up-to-date information at www.toxicology.org 209 - - - - . 2 L. Ritter
. D. D. and 1 . Annual Meeting Annual th , C. Burns 1 L. Ritter . College of Law, of Law, . College Marchant E. G. SOT's 45 SOT's J. S. Bus J. . Toxicology, Bayer Bayer Toxicology, . Tobia A. J. Canadian Network of Toxicology Centres, Toxicology of Canadian Network 2 Toxicology & Environmental Research and & Environmental Toxicology Consulting, Dow Chemical Company, Midland, Midland, Chemical Company, Consulting, Dow STUDIES. RESEARCH. 1 MI and Canada. of Guelph, Guelph, ON, University AND DESIGN STUDY TOXICOLOGY TO AS IT RELATED DOSIMETRY AND EPIDEMIOLOGY BIOMONTORING OF HORMESIS. MAINSTREAMING HORMESIS. INTEGRATING BIOMONITORING INTO INTO BIOMONITORING INTEGRATING TOXICOLOGY AND EPIDEMIOLOGY REGULATORY AND LEGAL IMPLICATIONS IMPLICATIONS AND LEGAL REGULATORY CropSceince, Research Triangle Park, NC. Park, Triangle CropSceince, Research TO BIOMARKERS OF EXPOSURE LESSONS LEARNT FROM CHEMICALS: Arbuckle. Biostatistics E. T. EPIDEMIOLOGY. Health Canada, Ottawa, Division, and Epidemiology Canada. Sponsor: ON, and J. S. Pierce. ChemRisk, San and J. Paustenbach CA. Francisco, Arizona State University, Tempe, AZ. Tempe, Arizona State University, THE CLINICAL IMPLICATIONS ARE WHAT Jonas. Samueli Institute, B. W. OF HORMESIS? Sponsor: E. Calabrese VA. Alexandria,
(Continued) Annual Annual th Biological Modeling SS Modeling Biological #1872 2:05 1:30 PM to 4:30 PM Room 7A INTO BIOMONITORING INTEGRATING SESSION: WORKSHOP RESEARCH TOXICOLOGY AND EPIDEMIOLOGY Midland, MI and Chemical Company, Bus, Dow Chairperson(s): James Guelph, ON, Centres, Toxicology of Canadian Network Ritter, Leonard Canada. by: Endorsed Epidemiology has well established methods for conducting research using questionnaires on self-reported intensity exposure.algorithms have been developed Categoriesto determine the of dose response exposureof the andputative health effect. has Toxicology also developed sophisticated pharmacokinetic models and dosing methods by which to hazards evaluate of specific chemicals or pesticides. Between the two disciplines epidemi #1870 4:00 mation obtained from recent exposure biomonitoring studies of farmers?How can detected levels of chemicals in the human population corresponded to dose/exposure metrics in be studies animal so toxicology that better findings of biomonitoring studies can be better related to potential adverse health outcomes? how Lastly, can biomonitoring, epidemiology and phar macokinetic tools be improved to better link traditional external exposure measures to actual measures of internal tissue doses? #1871 1:30 ology and toxicology, however, lies ology a and however, growing toxicology, body of biomonitoring data capturing real-world human exposures. Emerging data from both the CDC National Exposure Report and other tunitysimilar to studies better presents integrate an complexoppor exposure/doseevaluations of metricshuman intohealth improvedrisks. The objectives examineof thisseveral workshopkey questionswill addressing this task.in modernA epidemiology is criticalthe lack weaknessof validation of exposure. Can survey methodology in agricultural epidemiology studies be from improved infor #1868 2:50 #1873 2:40 Wednesday, March 8 March Wednesday, #1869 3:25 45 210 ------Meeting & ToxExpo & Meeting
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Center ChemRisk, 4 1 . 5 , E. Calabrese 1 Lawrence Livermore Livermore Lawrence 3 and W. Jonas W. and 4 Environmental Health Sciences, Environmental 2
D. J. Paustenbach J. D. . G. Marchant , G. 3
. Public Health, University of Health, University . Public Calabrese E. J. Amherst, MA. Massachusetts, AND HORMESIS: CANCER RISK AND IMPLICATIONS. PLAUSIBILITY K. T. Bogen. Energy & Environment L-396, & Environment Energy Bogen. T. K. National. Laboratory/ Livermore Lawrence California, CA. Sponsor: D. Livermore, University Paustenbach Bogen RESEARCH. CA, San Francisco, Institute, Alexandria, VA. Alexandria, Institute, SCIENTIFIC FOUNDATIONS. HORMESIS: HORMESIS: A CHALLENGE TO THE TO A CHALLENGE HORMESIS: AND LINEAR DOSE-RESPONSE MODEL, ASSESSMENT, IN RISK ITS IMPLICATIONS AND BIOMEDICAL POLICY, REGULATORY University of Massachusetts Amherst School of of Massachusetts University Amherst, MA, Health, Public National Laboratory, Livermore, CA, Livermore, National Laboratory, for Law, Science, & Technology, Arizona State Technology, Science, & for Law, AZ and Tempe, of Law, College University
45th Annual Meeting and ToxExpo and Meeting Annual 45th
Ethical, Legal, and Social Issues SS Legal, Ethical, Risk Assessment SS Risk Biological Modeling SS Biological Hormesis remains a topic controversial in the fields of toxicology and risk assessment. The reason, is that if the phenomenon generally exists for all toxic effects and all chemicals, this would put current approaches to regu #1867 2:15 #1866 1:35 RESEARCH CA ChemRisk Inc., San Francisco, Chairperson(s): Dennis Paustenbach, CA. ChemRisk Inc., San Francisco, Pierce, and Jennifer by: Endorsed 1:30 PM to 4:30 PM Room 8 THE TO A CHALLENGE HORMESIS: SESSION: WORKSHOP IN IMPLICATIONS AND ITS MODEL, LINEAR DOSE-RESPONSE AND BIOMEDICAL POLICY, REGULATORY ASSESSMENT, RISK Wednesday, March 8 March Wednesday, ship is most appropriate, and instead, a biphasic model would probably be considered most appropriate (with inclusion of a threshold). some chemicals In with addition, carcinogenic effects might reduce risk for cancer at certain exposure levels. For the chemicals whose most effects sensitive are adverse not cancer, a change in Adverse Effect the Level (NOAEL) would be This necessary. symposium approachwill for identifying the No provide a comprehensive overview of hormesis, and its potential impacts on risk assessment and regulatory as policy, well as its impact on chemo therapeutics. The legal hurdles to implementing such an approach will be discussed. In addition, the various changes in toxicology testing protocols that would be necessary to insure that hormesis is incorporated into regu latory decision making will be discussed. The practical adopting consequences the of concept of hormesis, specifically with diationrespect to of the contaminatedreme sites, settingother regulatory risk criteria will A will be physician discuss described. the of drinking water standards, impact of andhormesis on future biomedical and clinical The research. goal of this symposium is to bring together on perspectives this topic from various fields, and initiate a dialogue between those in support of and against the adoption of the hormetic dose-response model. Further, it will provide the toxicology community with the knowledge of one of the most contempo the scientific rooted debates among historically yet community. rary, #1865 1:30
lating chemicals into question. For carcinogens, there a re-evaluation would of need the currentto view be that the linear dose-response relation Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1874 3:15 STRENGTHS AND WEAKNESSES OF #1881 3:10 3-METHYLINDOLE-INDUCED DNA COLLECTING EXPOSURE DATA FROM DAMAGE LEADS TO CYTOTOXICITY QUESTIONNAIRES. P. Buffler2 and C. J. Burns1. AND P53 NUCLEAR LOCALIZATION. J. M. 1Epidemiology, The Dow Chemical Company, Weems, N. S. Cutler, W. K. Nichols and G. S. Yost. Midland, MI and 2School of Public Health, Pharmacology and Toxicology, University of Utah, University California, Berkeley, Berkeley, CA. Salt Lake City, UT. #1875 3:50 USE OF PHYSIOLOGICALLY BASED #1882 3:30 DIFFERENTIAL FORMATION OF PHARMACOKINETIC MODELING TO ESTROGEN AND ESTRADIOL BY CHARACTERIZE EXPOSURES ASSOCIATED PLACENTAL AROMATASE. J. Schulze2, WITH BIOMONITORING DATA. R. Conolly1, M. Schulze1 and C. Siegers1. 1Department of K. H. Liao2 and Y. Tan2. 1National Center for Experimental and Clinical Pharmacology and Computational Toxicology, U.S. EPA, Research Toxicology, Luebeck, Germany and 2Office of the Triangle Park, NC and 2Center for Human Health Dean, Frankfurt/Main, Germany. Assessment, CIIT Centers for Health Research, Research Triangle Park, NC. #1883 3:50 DONG QUAI INHIBITS HUMAN CYTOCHROMES P450 IN VITRO. H. E. Kleiner1, 2 and A. Keller3, 1. 1Pharmacology, Toxicology, Wednesday, March 8 & Neuroscience, Louisiana State University- 1:30 PM to 4:30 PM Health Sciences Center, Shreveport, LA, 2Cancer Room 7B Prevention & Control, Feist-Weiller Cancer Center, Shreveport, LA and 3Caddo Magnet High School, PLATFORM SESSION: BIOTRANSFORMATION Shreveport, LA. Chairperson(s): Garold Yost, University of Utah, Salt Lake City, UT #1884 4:10 THE TOXICOLOGICAL MECHANISM OF and Mary Beth Genter, University of Cincinnati, Environmental Health, STYRENE IN CYP2E1 TRANSGENIC CELLS. Cincinnati, OH. J. Chung, W. Yuan and J. Zheng. Pharmaceutical #1876 1:30 ROLE OF THE ARYL HYDROCARBON Sciences, Northeastern University, Boston, MA. RECEPTOR PATHWAY IN THE SYNERGISTIC DEVELOPMENTAL Wednesday, March 8 TOXICITY OF POLYCYCLIC AROMATIC 1:30 PM to 4:30 PM HYDROCARBONS IN ZEBRAFISH. R. Room 15A Di Giulio1, S. Billiard1, A. Timme-Laragy1, D. Wassenberg2, C. Cockman1 and E. Linney2, PLATFORM SESSION: BIOINFORMATICS AND BIOLOGICAL 1. 1Nicholas School of the Environment, Duke MODELING University, Durham, NC and 2Department of Molecular Genetics and Microbiology, Duke Chairperson(s): Charles Wang, University of California - Los Angeles, Los University, Durham, NC. Angeles, CA and Harvey Clewell, CIIT, Research Triangle Park, NC. #1877 1:50 ROLE OF AHR AND CYP1A1 IN #1885 1:30 EVALUATION OF THE TUMOR DOSE- NAPHTHALENE BIOACTIVATION. M. Genter, RESPONSE FOR PROPYLENE OXIDE J. Marlowe, N. Dragin, J. K. Kerzee, A. Puga, D. USING CFD MODELING AND THE 2-STAGE W. Nebert and T. P. Dalton. Environmental Health, CLONAL GROWTH MODEL. Y. Tan, J. S. University of Cincinnati, Cincinnati, OH. Kimbell, R. B. Conolly and H. J. Clewell. CIIT Centers for Health Research, Research Triangle #1878 2:10 STUDIES OF THE MECHANISMS OF Park, NC. TOXICITY OF POLYBROMINATED DIPHENYL ETHERS (PBDEs). J. M. Sanders1, #1886 1:52 DEVELOPMENT OF A REVERSE 2, L. Chen1, E. H. Lebetkin1, M. L. Cunningham1 DOSIMETRY SCREENING APPROACH and L. T. Burka1. 1Laboratory of Pharmacology and FOR THE INTERPRETATION OF Chemistry, NIEHS, Research Triangle Park, NC and BIOMONITORING DATA ON VOLATILE 2Department of Toxicology, NC State University, ORGANIC COMPOUNDS. H. J. Clewell, Y. Raleigh, NC. Tan and K. H. Liao. Center for Human Health Assessment, CIIT Centers for Health Research, #1879 2:30 CYP1C1 mRNA EXPRESSION IN FUNDULUS Research Triangle Park, NC. FOLLOWING BAP EXPOSURE. L. Wang1, B. E. Scheffler2, W. Dong1, A. Ford1 and K. L. Willett1. #1887 2:14 TOXICITY PREDICTION TOOLS FOR 1Pharmacology and Environmental Toxicology, ENDOCRINE DISRUPTION. M. A. Pasquinelli, University of Mississippi, University, MS and S. B. Little and J. R. Rabinowitz. National Center 2MSA Genomics Laboratory, USDA-ARS-CGRU, for Computational Toxicology, U.S. EPA, Research Stoneville, MS. Triangle Park, NC. #1880 2:50 IN VIVO MUTAGENICITY OF VINYL CARBAMATE IN LUNG AND VARIOUS TISSUES. L. G. Hernandez and P. Forkert. Anatomy and Cell Biology, Queen’s University, Kingston, ON, Canada. WEDNESDAY up-to-date information at www.toxicology.org 211
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2 2 , J. , J. C. . , , 1, 2 1 ORD/ -p- 2 B. and B. Health Risk Faculte Faculte 1 2 . , J. Pennings , J. N. Pumford , N. 2, 1 1 1, 2 J. DeWitt J. S. Lacour S. B. Pruett S. B. Curriculum in 1 Annual Meeting Annual . 2 th Drug Safety Evaluation, Drug Safety Evaluation, 1 Toxicology, Pathology Pathology Toxicology, . 2 K. Gilbert 2
, H. Neff-LaFord Cell and Molecular Biology Cell and Molecular Biology 2 R. Luebke Microbiology and Immunology, and Immunology, Microbiology 1 SOT's 45 SOT's . 1 and H. van Loveren S. Teske S. and 2, 3 2 and M. Pallardy 1 and E. S. Sobel. University of S. M. Roberts and E. S. Sobel. University , S. Blossom Toxicogenetics, LUMC, Leiden, Netherlands. Toxicogenetics, Program, University of Arkansas, Fayetteville, AR. Arkansas, Fayetteville, of University Program, IMMUNE FUNCTION IN RATS IMMUNE FUNCTION IN RATS TO EXPOSED DEVELOPMENTALLY DICHLORIDE. DIBUTYLTIN Analysis and Toxicology, Maastricht University, Maastricht University, Toxicology, and Analysis UNC, Chapel Hill, NC and Toxicology, Wang , Q. Zheng and R. Fan. Cellular BIology & Cellular BIology Zheng and R. Fan. , Q. Schwab Shreveport, LSU Health Sciences Center, Anatomy, H. van Steeg H. van and Maastricht, Netherlands, 3 C. Copeland LA. A POTENTIAL OF EXAMINATION FOR ACTION MODE OF ESTROGENIC OF ACCELERATION CHLORDECONE IN NZBXNZW/F1 MICE. AUTOIMMUNITY Florida, Gainesville, FL. CONTAMINANT ENVIRONMENTAL PROMOTES TRICHLOROETHYLENE AND INHIBITS DISEASE AUTOIMMUNE APOPTOSIS. T CELL Gautier Carolina, Columbia, SC. OF BIS(TRI- ANALYSIS MICROARRAY INDUCED (TBTO) N-BUTYLTIN)OXIDE K. Baken IMMUNOTOXICITY. SYNERGISTIC EFFECT OF BACTERIAL OF BACTERIAL SYNERGISTIC EFFECT ON LIPOPOLYSACCHARIDE PRODUCTION ACETAMINOPHEN-INDUCED 264.7 MOUSE THE RAW IN OF CYTOKINES CELL LINE. MACROPHAGE Triangle Research EPA, U.S. NHEERL/ETD/ITB, NC. Park, THE IMMUNE SYSTEM, NOT THE LUNG, AHR-MEDIATED OF TARGET THE IS IMMUNE ENHANCE INNATE THAT EVENTS VIRAL RESPIRATORY TO RESPONSES INFECTION. University of Arkansas for Medical Sciences/ of University Hospital Research Institute, Arkansas Children’s AR and Little Rock, Pathology & Microbiology, University of South University & Microbiology, Pathology P. Nagarkatti and P. Singh, M. Nagarkatti P. N. . Pharmaceutical Sciences, Washington Washington . Pharmaceutical Sciences, Lawrence WA. Pullman, State University, A PESTICIDE OF IMMUNOTOXICITY MECHANISM OF GREATER MIXTURE: INHIBITION OF ADDITIVE THAN PRODUCTION. CYTOKINE de Pharmacie, 461, Chatenay- INSERM UMR-S France. Malabry, 8-TETRACHLORODIBENZO 7, 3, 2, Netherlands and and Genetics, RIVM, Bilthoven, DIOXIN (TCDD) REQUIRES THE HELP (TCDD) REQUIRES DIOXIN TO OR MITOGEN OF DENDRITIC CELLS T CELLS IN PRIMARY APOPTOSIS INDUCE VITRO T CELL LINE IN AND ESTABLISHED sanofi aventis, Alfortville, and France sanofi aventis,
(Continued) Annual Annual th #1897 2:50 #1900 3:50 #1901 4:10 #1896 2:30 #1894 1:50 #1898 3:10 #1899 3:30 #1895 2:10 45 212
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J. J. R. H. Applied 4 European , M. V. V. , M. 2
2 . Cellular S. M. Hussain , 3 G. Natsoulis, . , J. S. Parker , J. Laboratory of Molecular Cambridge Cell Networks Cambridge Cell Networks 1 1 , L. Shi 1 1 . . 1 2 Cedars-Sinai Research Institute, Cedars-Sinai Research Institute, 1 , J. Xu , J. 1 . 4 . NIES, Tsukuba, Japan. Tsukuba, H. Sone. NIES, , F. M. Parham , F. 1 , Y. Tan Y. , and R. Russell 1, 2 1 C. J. Portier and C. J. 2 Constella Health Sciences, Durham, NC. 2 Department of Medicine, UCLA, Los Angeles, CA, Department Los of Medicine, UCLA, National Center for Toxicoinformatics, Center for Cedars-Sinai Medical Center, Los Angeles, CA, Los Cedars-Sinai Medical Center, Toxicology, NIEHS, Research Triangle Park, NC Park, Triangle NIEHS, Research Toxicology, SYSTEMS BIOLOGY APPROACH FOR APPROACH SYSTEMS BIOLOGY TOXICITY. MECHANISM OF ELUCIDATING ETHANOL DIMINISHES LPS-INDUCED AND CLUSTERING TLR4/CD14 RECEPTOR ACTIN THE CHANGES IN ASSOCIATED ACCUMULATION AND CYTOSKELETON AND SECRETED OF MEMBRANE BOUND Pruett Dai and S. B. TNF-ALPHA. Q. G. Apic G. Ltd., Cambridge, United Kingdom and M. Gohlke Smith and A. Tolley, J. Retief, B. Ganter, A. Engelberg, A. Engelberg, Ganter, Retief, B. J. Tolley, A. INTEGRATING TRANSCRIPTOMICS WITH TRANSCRIPTOMICS INTEGRATING FOR IDENTIFICATION CYTOTOXICITY RAT PRIMARY OF BIOMARKERS IN CADMIUM. TO EXPOSED HEPATOCYTES M. Frazier and J. 2 3 AR and Jefferson, Research, Toxicological BIology & Anatomy, LSU Health Sciences Center, LSU Health Sciences Center, Anatomy, & BIology LA. Shreveport, Toyoshiba and Toyoshiba and K. Jarnagin. Iconix Pharmaceuticals,Brennan CA. View, Mountain A GENE REGULATORY OF ELUCIDATION FOR FOREBRAIN NETWORK DEVELOPMENT USING BIOINFORMATICS OF ANALYSIS THE FOR APPROACHES DATASETS. COMPILED MICROARRAY COMMON GENE NETWORKS AT MOUSE AT COMMON GENE NETWORKS CARCINOGENS. TO LIVER EXPOSED C. Wang C. Molecular Biology Laboratory, Heidelberg, Heidelberg, Laboratory, Molecular Biology Sponsor: S. Boyer Germany. Biotechnology, U.S. Air Force Research Laboratory, Research Laboratory, Air Force U.S. Biotechnology, OH. AFB, Wright-Patterson ARE GENES A SMALL NUMBER OF A LARGE CLASSIFY TO SUFFICIENT TOXICOLOGICAL NUMBER OF UNIQUE END-POINTS AND PHARMACOLOGICAL USING GENE EXPRESSION.
45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1892 4:04 : Kathleen Gilbert, University of Arkansas for Medical for Arkansas of Chairperson(s): Kathleen Gilbert, University Triangle Research EPA, U.S. AR and Robert Luebke, Sciences, Little Rock, NC. Park, #1893 1:30 1:30 PM to 4:30 PM Room 5B IMMUNOTOXICITY SESSION: PLATFORM #1888 2:36
#1890 3:20 Program Description Description Program #1891 3:42 Wednesday, March 8 March Wednesday, #1889 2:58
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 #1908 3:42 HIGH THROUGHPUT SCREENING OF 1:30 PM to 4:30 PM MITOCHONDRIAL RESPIRATION USING Room 2 OXYGEN SENSING FLUORESCENCE PROBES. L. D. Marroquin1, K. Christiansen1, J. 2 2 1 1 PLATFORM SESSION: PREDICTING COMPOUND TOXICITY Hynes , D. Papkovsky , G. Stevens and Y. Will . 1Safety Sciences, Pfizer, San Diego, CA and Chairperson(s): William Brock, Brock Scientific Consulting LLC, 2Luxcel, Cork, Ireland. Montgomery Village, MD and Douglas A. Keller, sanofi-aventis, Malvern, #1909 4:04 MITOCHONDRIAL DYSFUNCTION CAN PA. EASILY BE DETECTED IN GALACTOSE #1902 1:30 EFFECT BASED CLASSIFICATION SCHEME GROWN CELLS USING OXYGEN SENSING FOR IN VITRO DATA TO PREDICT ACUTE FLUORESCENCE PROBES. L. D. Marroquin1, RODENT TOXICITY. A. Freidig, S. Dekkers, J. Hynes2, D. Papkovsky2, G. Stevens1 and Y. Will1. J. Bessems, M. Verwei and H. van de Sandt. TNO 1Safety Sciences, Pfizer, San Diego, CA and Quality of Life, Zeist, Netherlands. 2Luxcel, Cork, Ireland. #1903 1:52 DEVELOPING KNOWLEDGE OF STRUCTURE-ACTIVITY RELATIONSHIPS Wednesday, March 8 IN TOXICITY. N. Greene1, B. Acar-Chiaradia2, 1:30 PM to 4:30 PM C. McKay2, C. A. Marchant2, R. R. Note2 and M. Exhibit Hall L. Patel2. 1Safety Sciences - Groton, Pfizer Global Research & Development, Groton, CT and 2Lhasa POSTER SESSION: CHEMICAL-BIOLOGICAL WEAPONS II Limited, Leeds, United Kingdom. Chairperson(s): Richard Gordon, Walter Reed Army Institute of Research, #1904 2:14 MODELING AND INFORMATICS SUPPORT Silver Spring, MD. FOR SAFETY STUDIES IN EARLY DRUG DISCOVERY PROJECTS. S. C. Boyer, S. Displayed: 1:30 PM–4:30 PM W. Ernst, M. Graham and G. J. Oliver. Global Safety Assessment, AstraZeneca R&D Moelndal, Attended: 1:30 PM–3:00 PM Moelndal, Sweden. #1910 PROTECTIVE EFFECT OF A SMALL PEPTIDE AGAINST SULFUR MUSTARD- #1905 2:36 THREE DISTINCT PHARMACOLOGIC INDUCED LESIONS. Universtiy of. Wormser, AGENTS ASSOCIATED WITH HUMAN Y. Schussheim, A. Rosengarten, I. Shapira and B. IDIOSYNCRATIC HEPATOTOXICITY Brodsky. Pharmacology, The Hebrew University, DISPLAY COMMONALITIES IN GENE Jerusalem, Israel. EXPRESSION PROFILES IN LPS CO- TREATED RATS. M. J. Liguori1, J. F. Waring1, J. #1911 THE DETECTION OF FREE RADICAL P. Luyendyk2, X. Deng2, J. F. Maddox2, P. E. Ganey2, FORMATION FROM THE INTERACTION R. F. Stachlewitz1, E. A. Blomme1, W. B. Mattes3, G. OF SULFUR MUSTARD WITH NADPH N. Cosma3 and R. A. Roth2. 1Department of Cellular - CYTOCHROME P450 REDUCTASE. A. A. and Molecular Toxicology, Abbott Laboratories, Brimfield1, M. J. Novak2, A. M. Mancebo1, B. S. Abbott Park, IL, 2Department of Pharmacology Gallagher1 and C. M. Arroyo1. 1pharmacology and Toxicology, Michigan State University, East branch, U.S. Army Medical Research Institute of Lansing, MI and 3Pharmacia, Inc., Skokie, IL. Chemical Defense, APG/EA, MD and 2Chemistry, Florida Institute of Technology, Melbourn, FL. #1906 2:58 THE POSSIBILITY OF CHEMICAL COMPUTATION APPROACHES TO DRUDS #1912 INTERACTION OF SULFUR MUSTARD WITH PHOTOSAFETY EVALUATION. Y. Zhou1, H. NADPH-CYTOCHROME P450 REDUCTASE Yamada1, M. Sakimura1, M. Fujikawa1, I. Horii1 AND CYTOCHROME P450 ISOFORMS. A. and A. Ishibashi2. 1Safety Sciences, Pfizer Global M. Mancebo and A. A. Brimfield. Pharmacology Reseach & Development, Nagoya Laboratory, Branch, U.S. Army Medical Research Institute of Taketoyo, Aichi, Japan and 2Computational Chemical Defense, APG/EA, MD. Chemistry and Structural Sciences, Pfizer Global Reseach & Development, Nagoya Laboratory, #1913 REDUCTION OF MECHLORETHAMINE Taketoyo, Aichi, Japan. CYTOTOXICITY BY EBSELEN IN NORMAL AND TUMOR-DERIVED CELL #1907 3:20 HUMAN PBMCS AS AN IN VITRO MODEL LINES. D. Hardej and B. Billack. Department of FOR PREDICTING COMPOUND TOXICITY. Pharmaceutical Sciences, St. John’s University, N. Patil1, L. Brady1, S. Brown1, N. Faravashi1, E. Queens, NY. A. Blomme2, J. F. Waring2, Y. Yang2, S. J. Abel2, B. Eynon1, S. Fujimoto1, K. Kolaja1, D. N. Halbert1 and #1914 ENDOTHELIAL CELL ALTERATIONS G. Day1. 1Iconix Pharmaceuticals, Inc., Mountain FOLLOWING IN VITRO EXPOSURE View, CA and 2Abbott Laboratories, Abbott Park, TO SULFUR MUSTARD OR PLATELET IL. ACTIVATING FACTOR. O. E. Clark, E. W. Nealley, K. Leiter, A. L. Miller, J. D. Nicholson and W. J. Smith. Research Division, USAMRICD, Aberdeen Proving Ground, MD. WEDNESDAY up-to-date information at www.toxicology.org 213 ,
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, , J. , J. 2 US 1 1 . , K. 2 . 1 , R. 2 . 1 . Battelle 2 1 . 1 Medical 2 J. Rogers , J. , T. Hoffman T. , 1 S. A. Reutter , S. 1 1 P. McGinnis , P. 1 , C. Kelleher US Army Medical Army US 2 2 R. Gordon Battelle Memorial , L. Mitcheltree 1 2 , D. Lindsay , D. M. Nambiar . 1 2 and J. J. Bray J. and J. U.S. Environmental Environmental U.S. R. Casillas 1 Annual Meeting Annual 2 and R. Railer 2 th E. Marsh National Homeland and 2 1 and C. Sonich-Mullin 2 , M. Matthews P. Coleman , P. 1 1 , A. Douglas , 2 , E. Clarkson 1 Optimetrics, Inc., Bel Air, MD. Air, Optimetrics, Inc., Bel , R. Ratcliffe and S. Ryan 2 1 2 SOT's 45 SOT's , E. E. Shockley 1 , N. Washington , N. 2 T. Nichols , T. , T. Negley T. , 1 , M. Shutz 1 2 , N. Niemuth , N. , D. Vasconcelos , D. 1 , B. Doctor , B. 1 1 , L. Askins , L. , B. Martin , B. 1 1 Division of Biochemistry, Department Biochemical of Biochemistry, Division Syracuse Research Science Center, Environmental Security Research Center, Environmental Protection Environmental Security Research Center, OH. Cincinnati, Agency, ACTIVE THE EMERGENCY RESPONSE: TOXICOLOGISTS. OF ROLE AND CRUCIAL R. B. Crosier R. B. and C. A. Caraway. Office of A. Caraway. and C. DuTeaux S. B. Assessment, Cal EPA, Health Hazard Environmental AFFECT OF TEMPERATURE AND TEMPERATURE AFFECT OF TEMPORAL THE HUMIDITY ON RELATIVE OF RICIN ON INDOOR INACTIVATION MATERIALS. SURFACE Memorial Institute, Columbus, OH and Institute of Army Reed Walter Pharmacology, Spring, MD and Research, Silver Corp, Syracuse, NY and K. Newkirk Aberdeen Proving CB Center, Edgewood Army MD and Ground, W. Thayer W. Sacramento, CA. S. Schulz 1 1 Stone Graham D. A. Gray D. Owens PLAN SAMPLING VISUAL THE EVALUATING TESTS FOR DETECTING STATISTICAL AGENTS: THE PRESENCE OF BIOTHREAT THE EFFECTS OF CONSIDERING DISTRIBUTIONS POSITIVELY-SKEWED ON AUTOCORRELATION AND SPATIAL RATES. AND II ERROR TYPE I NOMINAL Institute, Columbus, OH and Baker B. Hart B. TOXICITY AGENT WARFARE CHEMICAL THE GENERAL FOR ESTIMATES R. Sommerville D. POPULATION. Toxicology Branch, Analytical Toxicology Division, Division, Toxicology Analytical Branch, Toxicology Chemical Medical Research Institute of Army U.S. MD. Ground, Aberdeen Proving Defense, AGENTS WARFARE CHEMICAL VESICANT) AND (ORGANOPHOSPHATES AND BIOLOGICAL DECONTAMINATION USING AND DETOXIFICATION SPONGES. POLYURETHANE Aberdeen Research Institute of Chemical Defense, Sponsor: MD. Ground, Proving Protection Agency, Research Triangle Park, NC. Park, Triangle Research Agency, Protection CHEMICAL BURN SUPERFICIAL DERMAL Reid WEANLING PIG. F. THE MODEL IN
(Continued) Annual Annual th #1927 #1922 #1926 #1925 #1924 #1923 45
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, 2 , R. D. , R. D. 4 SAS D. R. D. . 4 3 Directorate D. I. D. 1 . S. Casbohm S. I. Baskin 2
, W. Bao W. , 3 S. I. Baskin , 2 and Chemistry and 1 S. Omaye . 1, 3 1 Department of and SPORES. 3 1, 2 , E. J. Perkins , E. J. 2 US Army Medical Research Army US 2 and C. S. Phillips . Battelle Memorial Institute, 4 , G. A. Rockwood , G. Anatomy and Cell Biology, SUNY Cell Biology, and Anatomy 1 2 S. E. Czerwinski and B. A. Logue and B. N. Elsayed N. 2 , T. Chu T. , 4 J. F. Dillman F. , J. 1 Applied Pharmocology and Neurotoxicology and Neurotoxicology Applied Pharmocology Environmental Team, Molecular Ecology 2 3 Directorate of Laboratory Sciences, U.S. Army Army Directorate of Laboratory Sciences, U.S. Medical Army U.S. Division, Pharmacology Nutrition, University of Nevada, Reno, NV. of Nevada, Nutrition, University Scientific Affairs, Hurley Consulting Associates, Consulting Hurley ScientificAffairs, Downstate Medical Center, Brooklyn, NY and Brooklyn, Center, Medical Downstate G. E. Platoff Columbus, OH. E. B. Delpit, J. P. Long, P. H. Olson, R. E. Barnewall, Barnewall, E. R. Olson, H. P. Long, P. J. Delpit, B. E. Wolfinger CHALLENGED WITH AEROSOLIZED AEROSOLIZED WITH CHALLENGED ANTHRACIS BACILLUS P. J. Sabourin J. E. Estep, P. , J. LeClaire R. E. Hunt, R. D. and C. L. Sabourin Bannon 1 Center for Health Promotion and Preventive MD, Ground, Aberdeen Proving Medicine, 2 Aberdeen Research Institute of Chemical Defense, MD and Ground, Proving Maserek-Ruud Brookings, SD and CYTOSKELETAL TARGETS AND PATHWAYS AND PATHWAYS TARGETS CYTOSKELETAL R. J. BY SULFUR MUSTARD. DAMAGED F. C. R. Braue, C. S. Phillips and J. Werrlein, Branch, Dillman. Cell and Molecular Biology MD. Ground, Aberdeen Proving USAMRICD, THE CYANIDE FEASIBILITY OF USING 2-AMINOTHIZOLINE-4- METABOLITE A RETROSPECTIVE AS ACID CARBOXYLIC W. EXPOSURE. MARKER OF CYANIDE 1 3 UPREGULATION OF THE GAMMA-2 CHAIN THE GAMMA-2 OF UPREGULATION IN SULFUR OF LAMININ-332 (LAMININ-5) MOUSE SKIN. TREATED MUSTARD Chatham, NJ, of Toxicology Army Center for Health Promotion Army Toxicology of Ground, Aberdeen Proving Medicine, and Preventive MD, Institute of Chemical Defense, Aberdeen Proving Aberdeen Proving Institute of Chemical Defense, MD. Ground, ON METALS EFFECTS OF HEAVY CYANIDES. Pharmacology, University of Maryland, Baltimore, of Maryland, University Pharmacology, Baltimore, MD. AND GENE RDX EXPOSURE ACUTE BRAIN. THE RAT EXPRESSION IN Branches Army Medical Research Institute of Army Branches Ground, Aberdeen Proving Chemical Defense, MD, Engineering Research and Army Laboratory MS and Vicksburg, Center, Development Institute Inc., Cary, NC. Institute Inc., Cary, OF ANALYSIS CYTOMETRIC FLOW ANTIGEN-STIMULATED PROTECTIVE AND PRODUCTION T CELL CYTOKINE IN RHESUS MACAQUES PROLIFERATION and Y. Chang. Y. and A. Hahn, M. K. Gordon , R. Gerecke Ernest Mario Toxicology, in Joint Graduate Program Piscataway, Rutgers University, School of Pharmacy, NJ. BIOCHEMICAL PULMONARY INDUCED BY SYSTEMIC ALTERATIONS OF NITROGEN ADMINISTRATION MUSTARD. Biochemistry, South Dakota State University, State University, Dakota South Biochemistry, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#1915 Program Description Description Program #1919 #1920 #1921 #1916
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 #1934 IN-VIVO ESTROGENIC AND 1:30 PM to 4:30 PM ANTIESTROGENIC EFFECTS OF THE PBDE 1 Exhibit Hall MIXTURE DE-71. M. Mercado Feliciano and R. M. Bigsby2. 1Pharmacology and Toxicology, Indiana 2 POSTER SESSION: ENDOCRINE DISRUPTORS University, Indianapolis, IN and Obstetrics and Gynecology, Indiana University, Indianapolis, IN. Chairperson(s): Raphael Witorsch, Virginia Commonwealth University, #1935 Richmond, VA and Xiaojuan Wang, CIIT Centers for Health Research, TRANSCRIPTIONAL CONTROL OF Research Triangle Park, NC. LARGEMOUTH BASS (LMB) ESTROGEN RECEPTORS ALPHA, BETA-A AND BETA- Displayed: 1:30 PM–4:30 PM B BY METHOXYCHLOR (MXC) AND ITS METABOLITES, MONO- AND BIS- Attended: 3:00 PM–4:30 PM HYDROXYMETHOXYCHLOR IN HEPG2 CELLS. J. L. Blum1, L. D. Stuchal2, M. O. #1928 NUCLEAR RECEPTOR COREGULATORS James2 and N. D. Desnlow3. 1Pharmacology and AND ESTROGEN SENSITIVITY IN Therapeutics, University of Florida, Gainesville, REPRODUCTIVE ORGANS AND BRAIN FL, 2Medicinal Chemistry, University of Florida, AFTER DEVELOPMENTAL EXPOSURE Gainesville, FL and 3Physiological Sciences, TO AN ENDOCRINE DISRUPTER, 4- University of Florida, Gainesville, FL. METHYLBENZYLIDENE CAMPHOR. W. Lichtensteiger, S. Durrer, C. Ehnes, M. Fuetsch, #1936 DEVELOPMENT OF AN ENDOCRINE M. Henseler, K. Maerkel and M. Schlumpf. DISRUPTOR BIOASSAY USING GREEN Toxicology, University of Zurich, Zurich, INDUCTION OF VITELLOGENIN IN Switzerland. Sponsor: R. Peterson. CALIFORNIA HALIBUT (PARALYCHTHYS CALIFORNICUS). A. Palumbo1, M. Koivunen2 #1929 ESTROUS CYCLICITY OF THE FISCHER 344 and R. S. Tjeerdema1. 1Environmental Toxicology, RAT FOLLOWING INHALATION EXPOSURE University of California, Davis, Davis, CA and WITH OCTAMETHYLCYCLOTETRASILOX 2Entomology, University of California, Davis, Davis, ANE (D4). A. L. Quinn, J. M. Regan, B. J. Marinik, CA. J. M. Tobin, S. D. Crofoot and K. P. Plotzke. Health and Environmental Sciences, Dow Corning #1937 HERSHBERGER ASSAY: CODED AGONIST Corporation, Auburn, MI. AND ANTAGONIST STUDIES. E. L. Moore, L. A. Waterson and S. Ruckman. Huntingdon Life #1930 ESTROGENIC POTENCY OF MANY Sciences Ltd., Huntingdon, United Kingdom. POPULAR SUNCREENS AND LOTION COMPONENTS DETECTED USING THE #1938 EFFECTS OF DI(N-BUTYL)PHTHALATE LUMI-CELL® ER BIOASSAY. J. D. Gordon1, ON GENE EXPRESSION OF THE MALE A. C. Chu1, M. D. Chu2, C. Matherly1, M. S. REPRODUCTIVE ORGANS. T. Kang, H. Kang, Denison3, G. Grune4 and G. C. Clark1. 1Xenobiotic T. Kim, H. Moon, I. Kang, Y. Jun, E. Choi, I. Kim, S. Detection Systems, Inc., Durham, NC, 2Analytical Han and J. Hong. KFDA/NITR, Seoul, South Korea. Perspectives, Wilmington, NC, 3Department of Environmental Toxicology, University of California, #1939 CUMULATIVE EFFECTS OF IN UTERO Davis, Davis, CA and 4ePatentmanager.com, VA ADMINISTRATION OF A MIXTURE OF Beach, VA. SEVEN ANTIANDROGENS ON MALE RAT REPRODUCTIVE DEVELOPMENT. L. E. Gray #1931 IDENTIFICATION OF CIRCADIAN RHYTHM and J. Furr. ORD, NHEERL, RTD, EB, U.S. EPA, REGULATORS AS EARLY ESTROGEN- Research Triangle Park, NC. RESPONSIVE GENES IN THE IMMATURE MOUSE UTERUS. J. G. Moggs, R. Stuckey, H. #1940 IN VITRO EVALUATION OF OCTAMETHY Tinwell, D. Moore, F. Lim, I. Kimber, J. Ashby, LCYCLOTETRASILOXANE (D4) AND DEC G. Orphanides and R. Currie. Syngenta CTL, AMETHYLCYCLOPENTASILOXANE (D5) Macclesfield, Cheshire, United Kingdom. AS PROGESTERONE RECEPTOR LIGAND. K. P. Plotzke, P. A. Jean, J. A. Arthurton and S. D. #1932 NATURE OF BINDING INTERACTION Crofoot. Dow Corning Corporation, Midland, MI. OF SELECTED CHEMICALS WITH RAT ESTROGEN RECEPTORS. J. Eldridge1, #1941 2DPAGE AND ITRAQ LABELING: S. Yavanhxay1, R. Cooper2 and S. Laws2. COMPLEMENTARY TOOLS FOR IN-VIVO 1Physiol-Pharmacology, Wake Forest University ASSESSMENT/DIAGNOSIS OF AMPHIBIAN Winston-Salem, NC and 2Repro Toxicology THYROID AXIS-DISRUPTING CHEMICALS. Division, NHEERL, U.S. EPA, Res Tri Park, NC. J. Serrano1, 2, B. Withuhn2, L. Higgings2, J. Korte1, G. Holcombe1, P. Kosian1, J. Tietge1 and S. Degitz1. #1933 ESTROGEN-MEDIATED GENE EXPRESSION 1NHEERL- MED. Duluth, U.S. EPA, Duluth, OF REDOX SENSITIVE CELL SIGNALING MN and 2Biochemistry and Molecular Biology, PROTEINS. K. Triff, Q. Felty and D. Roy. University of MN, St Paul, MN. Sponsor: J. Nichols. Environmental & Occupational Health, Florida International University, Miami, FL. WEDNESDAY up-to-date information at www.toxicology.org 215 .
, . 1 1 C. , 1 , F. E. , F. 1 Center for 3 Department of . 1 . K. Yamazaki , K. 1 Annual Meeting Annual th 1, 2, 3 and M. van den Berg 2 , P. van Binsbergen van , P. 1 SOT's 45 SOT's , J. K. Taylor and Taylor K. , J. Witorsch R. J. , S. Ruchirawat and M. Komiyama 1 1, 2, 3 Laboratory of Medicinal Chemistry, Chulabhorn Laboratory of Medicinal Chemistry, for Future Health Science Project Environmental Institute for Risk Assessment Sciences (IRAS), Assessment Sciences (IRAS), Institute for Risk H. Hicks, A. Ashizawa and C. De Rosa. ATSDR, ATSDR, and C. De Rosa. Ashizawa A. H. Hicks, Research Institute, Bangkok, Thailand. Research Institute, Bangkok, TO EXPOSURE EFFECTS OF NEONATAL AQUAPORIN ON DIETHYLSTILBESTROL ASSESSMENT OF THE EFFECTS OF ASSESSMENT OF CHEMICALS ON STEROIDOGENESIS Utrecht, Netherlands and Utrecht University, 2 GENE EXPRESSION LEVELS IN MOUSE Yanagisawa Y. EPIDIDYMIS. Mori 2 Generations, Graduate School of Medicine, Chiba, Japan and Chiba University, Sciences, Chiba Health and Field Environment, Japan. Kawasaki, University, OF TOXICITY DEVELOPMENTAL A MECHANISTIC THERE IS NITRATES: PRODUCTION? NITRIC OXIDE TO LINK A. LeBlanc. Environmental and G. B. S. Reeves North Carolina State Toxicology, and Molecular Raleigh, NC. University, IMPACTS HEALTH ADVERSE IDENTIFYING EXPOSED VULNERABLE POPULATIONS IN of.S. THE Universtiy IN CONTAMINANTS TO AN OVERVIEW. LAKES REGION: GREAT Fowler Atlanta, GA. Sponsor: B. USING HUMAN H295R CELLS BY USING HUMAN H295R A OF MEASUREMENT SIMULTANEOUSLY Terasaki, HORMONES. N. DOZEN STEROID Tsutsui. and N. Ikeda Y. Hamano, T. Yamazaki, M. Mitsubishi Pharma Laboratory, Toxicology Sugimoto Corporation, Chiba, Japan. Sponsor: J. THE DETECTION OF FOR MICROASSAY AGONIST/ANTAGONIST GLUCOCORTICOID IN ENVIRONMENTAL ACTIVITY CHEMICALS. Daamen 1 C. S. Jones. Physiology, Virginia Commonwealth Commonwealth Virginia C. S. Jones. Physiology, VA. Richmond, University, A P450 17 (CYP17), CYTOCHROME FOR CANCER TARGET POTENTIAL Duursen van M. B. CHEMOPREVENTION. R. Fernandez Canton R. Fernandez Bioenvironmental Medicine, Graduate School Medicine, Graduate Bioenvironmental Chiba, Japan, of Medicine, Chiba University,
(Continued) Annual Annual th #1952 #1949 #1953 #1954 #1950 #1951 45
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2 Toxicologic Toxicologic 1 World Wide Wide World . 1 2 . 2 , S. B. Metzdorff , S. B. , R. Pero 1 J. R. Latendresse J. 2 Department of 1 . 1 . IN FETAL RAT RAT γ IN FETAL , J. Borch , J. 1 , E. Olson and C. Bagi 2 2 and D. R. Doerge and D. , J. Ferrell, D. Best, A. Best, D. Ferrell, S. Laws, J. 1
. . DepartmentTjalkens of and R. B. M. Hornung and M. Dalgaard 2 , N. Hanson , N. 2 , C. Andresen , C. 1 Department of Physiology, Institute of Department of Physiology, 2 Biochemical Toxicology, NCTR, Jefferson, AR. NCTR, Jefferson, Toxicology, Biochemical Pfizer and Medicine, Physiology Inc., Comparative L. Brokken Pathology Associates, Inc., Jefferson, AR and Associates, Inc., Jefferson, Pathology J. J. Korte, H. M. Kerr, M. E. Bugge, L. M. Korte, M. E. Bugge, L. M. Korte, H. M. Kerr, Korte, J. J. and S. J. Tietge E. Holcombe, J. W. G. A. Kosian, P. Duluth, EPA, U.S. NHEERL, ORD, MED., Degitz. Sponsor: MN. Toxicology and Risk Assessment, Danish Institute Assessment, Danish Institute and Risk Toxicology Denmark Research, Soborg, Veterinary and for Food A. Murr and S. Laws, A. Buckalew, R. L. Cooper, Research NHEERL, ORD, RTD, Stoker. EB, T. NC. Park, Triangle and Sponsor: E. Gray 2 Vinggaard A. TESTIS. L. Muskhelishvili 2 D VITAMIN OF TOXICITY AND ACTION ON BONE METABOLISM. ANALOGS Nduaka Groton, CT. ALTERS DIETHYLHEXYL PHTHALATE THE EXPRESSION OF STEROIDOGENIC AND PPAR FACTOR-1 DEIODINASE TYPE I, II, AND III II, I, TYPE DEIODINASE AMPHIBIAN PITUITARY, EXPRESSION IN KEY AT LIMB BUD AND THYROID, AFTER AND OF DEVELOPMENT STAGES HORMONE THYROID THE TO EXPOSURE METHIMAZOLE, MODULATORS: PROPYLTHIOURACIL. AND PERCHLORATE Buckalew, A. Murr and R. Cooper. RTD, NHEERL, RTD, A. Murr and R. Cooper. Buckalew, NC. Park, Triangle Research EPA, U.S. ORD, CHLOROTRIAZINE-INDUCED OF CELLULAR CALCIUM ALTERATIONS AND LH RELEASE IN SIGNALING A. Nichols, T. CELLS. ANTERIOR PITUITARY H. Hanneman W. Safety Sciences, Pfizer Inc., Groton, CT and CONFIRMATION OF AMMONIUM OF CONFIRMATION DIFFUSE PERCHLORATE-INDUCED THYROID HYPERPLASIA OF PATHOLOGIC THE RAT FOLLICULAR EPITHELIUM IN KI-67. TO ANTIBODY USING Environmental and Radiological Health, Colorado and Radiological Environmental Collins, CO. Fort State University, TUBERO- OF ROLE POTENTIAL NEURONS DOPAMINERGIC INFUNDIBULAR OF PITUITARY THE DISRUPTION IN ATRAZINE. HORMONE SECRETION BY ATRAZINE STIMULATES THE RELEASE OF THE RELEASE STIMULATES ATRAZINE MALE IN STEROIDS ADRENAL AND ACTH RATS. WISTAR Lariviere Biomedicine, University of Turku, Turku, Finland. Finland. Turku, Turku, of Biomedicine, University 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1944 #1945 #1942 #1947 #1943 #1948
#1946 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 #1962 DEMONSTRATION OF DIFFERENTIAL 1:30 PM to 4:30 PM TOXICITY INDUCED BY AMINOFLAVONE Exhibit Hall PRODRUG IN HUMAN AND RAT PRECISION CUT LUNG SLICES. H. Behrsing1, C. Ip2, T. Le2, 3 2 2 2 POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS J. Tomaszewski , C. Green , C. Tyson and K. Amin . 1HepaHope, Inc., Irvine, CA, 2Biosciences Division, Chairperson(s): Albert Li, Advanced Pharmaceutical Sciences, Columbia, SRI International, Menlo Park, CA and 3National MD and Frank Barile, St. John’s University, Jamaica, NY. Cancer Institute, Rockville, MD.
Displayed: 1:30 PM–4:30 PM #1963 HUMAN AND RAT LUNG TISSUE EXHIBIT DIFFERENTIAL SENSITIVITY Attended: 1:30 PM–3:00 PM TO PHORTRESS TOXICITY : USE OF PRECISION-CUT LUNG SLICES. K. Amin1, #1955 NON INVASIVE IN VIVO IMAGING OF C. Ip1, T. Le1, J. Tomaszewski2, C. Green1, C. Tyson1 HEPATOBILIARY STRUCTURE, FUNCTION and H. Behrsing3. 1Biosciences Division, SRI AND XENOBIOTIC RESPONSE IN A International, Menlo Park, CA, 2National Cancer TRANSPARENT FISH MODEL, THE SEE- Institute, Rockville, MD and 3HepaHope Inc., THROUGH MEDAKA (ORYZIAS LATIPES). Irvine, CA. R. Hardman, D. Hinton and S. Kullman. Nicholas School of the Environment and Earth Sciences, #1964 ASSESSMENT OF HUMAN Duke University, Durham, NC. HEMATOPOIETIC PROGENITOR PROLIFERATION IN A HIGH-THROUGHPUT #1956 COMPARATIVE PROTEOMIC ANALYSIS OF ASSAY. C. Pereira1, J. Damen1, A. Eaves1, 2 and E. RAT LIVER BIOPSIES AND DERIVATIVE 3-D Clarke1. 1StemCell Technologies, Vancouver, BC, LIVER CELL CULTURES. A. Wallington, W. M. Canada and 2Terry Fox Laboratory, Vancouver, BC, Purcell, J. T. Hancock, J. Hancock, J. Xu and N. D. Canada. Sponsor: R. MacFarland. Avent. Faculty of Applied Sciences, University of the West of England, Bristol, United Kingdom. #1965 IN VITRO TOXICITY OF LOWER IGNITION PROPENSITY (LIP) AND CONVENTIONAL #1957 VALIDATION OF THE INTEGRATED CIGARETTES. G. Lulham1, J. Miller2, W. S. MULTIPLE ORGAN CO-CULTURE Rickert3 and A. Trivedi3. 1JTI-Macdonald Corp., (IDMOC) ASSAY FOR MULTIPLE ORGAN Toronto, ON, Canada, 2JT International SA, Geneva, CYTOTOXICITY. A. P. LI1, 2 and N. M. Li2. Switzerland and 3Labstat International, Kitchener, 1Advanced Pharmaceutical Sciences, Columbia, MD ON, Canada. and 2In Vitro ADMET Laboratories, The ADMET Group LLC, Rockville, MD. #1966 FUNCTIONAL CHARACTERIZATION OF A HUMAN RENAL EPITHELIAL CULTURE #1958 USE OF AN ADENOSINE TRIPHOSPHATE MODEL. M. J. Powers1, S. Damian1, S. Hauber1, CYTOTOXICITY (ATP) ASSAY IN NORMAL P. Zeigler1, K. Mou2, J. Lee2, J. Li2 and I. J. HUMAN EPIDERMAL KERATINOCYTES TO Hidalgo2. 1Cambrex Bio Science Walkersville, Inc., PREDICT SYSTEMIC TOXICITY IN VITRO. Walkersville, MD and 2Absorption Systems, LP, E. Choi1, C. Danilo1, I. Rybina1, R. Samia1, H. A. Exton, PA. Raabe2, G. O. Moyer2 and J. W. Harbell2. 1Cambrex Corporation, North Brunswick, NJ and 2Institute for #1967 CHARACTERIZATION OF A CYNOMOLGUS In Vitro Sciences, Inc., Gaithersburg, MD. MONKEY KIDNEY-DERIVED CELL LINE, JTC-12, FOR SUITABILITY IN TOXICITY #1959 IN-2001 IS A NOVEL HISTONE EVALUATIONS. D. D. Baker, S. Sawant, M. DEACETYLASE INHIBITOR WITH POTENT Cosenza, C. Afshari and R. Dunn. Amgen, Thousand ANTITUMOR ACTIVITY AGAINST BREAST Oaks, CA. CANCER IN VITRO AND IN VIVO. K. N. Min, K. E. Jeong, Y. W. Kim, K. Y. Kim, J. H. Kim, D. #1968 REDUCING ANIMAL USE IN ACUTE Kim and Y. Y. Sheen. Pharmacy, Ewha Womans SYSTEMIC TOXICITY TESTING BY USING University, Seoul, seoul, South Korea. IN VITRO CYTOTOXICITY ASSAYS FOR ESTIMATING STARTING DOSES. J. A. #1960 AUTOMATED MEASUREMENT OF Strickland1, 2, M. W. Paris1, 2, S. Casati3, R. R. Tice2, ANGIOGENIC TUBE FORMATION USING W. S. Stokes2, R. Lee4, E. Harvey4, J. Haseman5, A QUANTITATIVE, CELL-BASED IMAGING H. Raabe6, C. Cao7, R. Clothier8, G. Mun4, A. ASSAY. R. N. Ghosh, L. E. Grove and O. Lapets. Sizemore6, G. Moyer6, J. Madren-Whalley6, C. Cellomics, Inc., Pittsburgh, PA. Sponsor: A. Krishna7, M. Owen8, N. Bourne9, N. Wenk9 and M. Barchowsky. Vallant10. 1Integrated Laboratory Systems, Inc., #1961 A GLOBAL GENE EXPRESSION Research Triangle Park, NC, 2NICEATM, NIEHS/ COMPARISON OF MOUSE LUNG CELLS IN NIH/DHHS, Research Triangle Park, NC, 3ECVAM, VIVO AND IN VITRO. L. Berndt1, A. Williams2, P. JRC, Ispra, Italy, 4Constella Group, Durham, NC, A. White1, J. Gingerich1, G. R. Douglas1 and C. L. 5Consultant, Raleigh, NC, 6IIVS, Gaithersburg, MD, Yauk1. 1Mutagenesis Section, Safe Environments 7US Army ECBC, Aberdeen Proving Ground, MD, Programme, Health Canada, Ottawa, ON, Canada 8University of Nottingham, Nottingham, United and 2Biostatistics and Epidemiology Division, Safe Kingdom, 9BioReliance Corp., Rockville, MD and Environments Programme, Health Canada, Ottawa, 10NIEHS, NIEHS/NIH/DHHS, Research Triangle
ON, Canada. Park, NC. WEDNESDAY up-to-date information at www.toxicology.org 217 . . .
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). AdvoCare AdvoCare , E. CARICA 3 S. J. and S. J. 1 2
Scantox A/S, Scantox Genencor 2 QBM Cell , S. 1 3 3 . S. M. Nataraj, A. D. Weissman A. D. 2 Q. Q. Bui Q. Q. Cellular& 1 . Department of 1 1 , N. Patel , N. 1 . Annual Meeting Annual 2 th Department of Nutrition, 2 , B. Tinner , B. 1, 2 Centre for Research in , R. M. Hackman 2 1 , J. Rathod , J. 1 SOT's 45 SOT's African Society for Toxicological Toxicological African Society for and A. Christensen and 2 H. M. Lantum 2 and W. A. Staines W. and 3 and , S. Patel 1 1 Divi. of Pharmacology Scs., Long Island of Pharmacology Divi. 1 , D. Zinkovsky , D. . 1 3 University of California, Davis, CA and of California, Davis, University University, Brooklyn, NY, NY, Brooklyn, University, International Inc., Palo Alto, CA and International Inc., Palo TOXICITY RISK ASSESSMENT OF RISK TOXICITY IN VITRO AN IN OF VALIDATION FURTHER B. Tungla B. Lille Skensved, Denmark. Lille Skensved, Cameroon and NY. Sciences (ASTS), Rochester, OF POTENTIAL CHEMOPROTECTIVE OCCURRING A NATURALLY NARINGENIN, IN DOXORUBICIN FLAVANONE, CITRUS INDUCED CLASTOGENICITY. E. Kannan and S. Bhojraj. Pharmacology R. Reddy, of Pharmacy, College J.S.S. Toxicology, and Bommu India. Sponsor: P. Tamilnadu, Ootacamund, LONG-TERM EXPOSURE EFFECTS PHYTOCHEMICAL- A NOVEL OF MIXTURE (METABOLIC NUTRACEUTICAL NUTRITION SYSTEM-PLATINUM) AND BIOCHEMISTRY ON SERUM VITAL OF SEVEN HISTOPATHOLOGY ORGANS OF B6C3F1 MICE. TARGET Bulku Stohs USE OF CRYOPRESERVED PRIMARY PRIMARY USE OF CRYOPRESERVED TOXICITY CELLS FOR NEURONAL CELL SCREENING IN MULTIWELL A. Krantis CULTURE. Molecular Medicine, University Ottawa, Ottawa, Molecular Medicine, University Canada, ON, Ottawa, C. N. Edwards C. N. VandenHoek NovaScreen Biosciences, Caliper Life Sciences, Biosciences, Caliper NovaScreen MD. Hanover, S. D. Ray S. D. NEUROTOXICITY DATABASE. NEUROTOXICITY Biopharmaceutics & Biotechnology, University University Biopharmaceutics & Biotechnology, Canada and ON, Ottawa, of Ottawa, Aschner Sponsor: M. Canada. ON, Science, Ottawa, International,TX. Carrolton, ALPHA AN OF SAFETY EVALUATION FROM AMYLASE (EBS-2) PRODUCED LICHENIFORMIS. BACILLUS LEAVES AQUEOUS EXTRACT IN EXTRACT AQUEOUS LEAVES PAPAYA NOVEGICUS (RATTUS ALBINO RATS Biochemistry, University of Yaounde I, Yaounde, Yaounde, I, Yaounde of University Biochemistry,
1:30 PM–4:30 PM 3:00 PM–4:30 PM (Continued) Annual Annual th #1979 #1977 #1976 : Jay Vodela, U.S. Department of Agriculture, Washington, Washington, Agriculture, Department of U.S. Vodela, Chairperson(s): Jay UT. Logan, Utah State University, Jr., A. Coulombe, DC and Roger Displayed: Attended: #1978 #1975 1:30 PM to 4:30 PM Exhibit Hall AND NUTRITION FOOD SAFETY POSTER SESSION: Wednesday, March 8 March Wednesday, #1980 45 , 218
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Meeting & ToxExpo & Meeting , 3 1 1 , 4 B. , B. 1 , N. , N. IN 6 Institute , P. , P. 2 7 , S. Casati , M. Paris viaBILITY. , R. Clothier Integrated 1 -ACTIN β-ACTIN 5 1 1, 2 F. and F. , M. Hoitink . 1 10 I. Gubbels Constella Group, , G. O. Moyer , G. O. 8
4 University of University , M. Owen 6 5 C. Cao , 4 , J. Haseman , J. 8 US Army ECBC, Army US 5 J. Strickland , J. R. Konsoula 1 Intergrated Laboratory J. Strickland , J. 1 . , H. Barentsen 1, 2 2 1 Regulatory Affairs, NOTOX NOTOX Affairs, Regulatory and M. Vallant and M. ECVAM, JRC, Ispra, Italy, Italy, JRC, Ispra, ECVAM, , R. Lee 1 , A. Sizemore , , C. Krishna 9 3 8 4 5 , H. Raabe . 2 1 BioReliance Corp., Rockville, MD 9 J. Charles J. , I. Meerts 2 , G. Mun 4 , M. Wenk , M. 8 , E. Harvey W. Stokes , W. W. Stokes and W. 6 2 2 NIEHS, DHHS/NIH, Research Triangle Park, Park, Triangle NIEHS, DHHS/NIH, Research NICEATM, DHHS/NIH/NIEHS, Research NICEATM, 2 10 IIVS, Gaithersburg, MD, MD, IIVS, Gaithersburg, Raleigh, NC, Consultant, Private NICEATM, NIEHS/NIH/DHHS, Research Triangle Triangle Research NIEHS/NIH/DHHS, NICEATM, J. Harbell J. R. Tice R. F. A. Barile. Pharmaceutical Sciences, and F. Pai S. J. Jamaica, of Pharmacy, College University St. John’s NY. VITRO OF IN CORRELATION NEUTRAL RED UPTAKE METHODS NEUTRAL RED UPTAKE VITRO EVALUATE TO STUDY VALIDATION A FROM FOR ASSAYS CYTOTOXICITY VITRO IN SYSTEMIC ACUTE RODENT ESTIMATING M. Paris TOXICITY. . Pharmaceutical Sciences, St. John’s A. Barile. Pharmaceutical Sciences, St. John’s Jamaica, NY. of Pharmacy, College University ON METALS TRACE EFFECT OF A. Barile. Pharmaceutical Sciences, Calabro and F. Jamaica, of Pharmacy, College University St. John’s NY. AND EXISTING CHEMICALS. Blaauboer Utrecht, Netherlands. REPEATED DAILY EFFECT OF SUBACUTE 18 CHEMICALS ON TO EXPOSURE HUMAN IMMORTAL CULTURED EPITHELIAL CELL INTESTINAL Nottingham, Nottingham, United Kingdom, 7 Durham, NC, and NC. APPROACH TESTING AN INTEGRATED OF NEW THE SAFETY EVALUATION FOR Crockett Park, Triangle Laboratory Systems, Inc., Research NC, 4 THE USE OF MOUSE FIBROBLAST (3T3) FIBROBLAST THE USE OF MOUSE EPIDERMAL AND NORMAL HUMAN (NHK) CYTOTOXICITY KERATINOCYES ORAL ACUTE FOR ESTIMATING ASSAYS AND OF FORMULATIONS TOXICITY MIXTURES. 2 NC. Park, FOR ANALYSES REPRODUCIBILITY Madren-Whalley J. and J. v.d. Hoeven v.d. and J. EXPRESSION AND NEWLY SYNTHESIZED AND NEWLY EXPRESSION HUMAN IN CULTURED PROTEINS A. R. EPITHELIAL CELLS. INTESTINAL Systems, Inc., Research Triangle Park, NC and NC and Park, Triangle Systems, Inc., Research R. Tice R. Bourne for Risk Assessment Sciences, Utrecht University, Assessment Sciences, Utrecht University, for Risk WITH PARACELLULAR CYTOTOXICITY RAT PERMEABILITY IN MORTAL CELLS. INTESTINAL Triangle Park, NC, Park, Triangle MD, Ground, Aberdeen Proving B.V., ‘s-Hertrogenbosch, Netherlands and Netherlands and ‘s-Hertrogenbosch, B.V., 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1973 #1974 #1972 #1971 #1970 #1969 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #1981 SUBACUTE ORAL TOXICITY OF PHASE #1988 DOCOSAHEXAENOIC ACID DEFICIENCY 2 STARCH NEUTRALIZER™ (PHASE 2®), AND SUPPLEMENTATION DISTINCTLY A STANDARDIZED WHITE KIDNEY BEAN ALTER HEPATIC mRNA EXPRESSION OF (PHASEOLUS VULGARIS) EXTRACT IN RATS. UPTAKE AND EFFLUX TRANSPORTERS D. H. Bechtel1, K. Vega1 and M. Skop2. 1CANTOX IN RATS. H. Lu, M. Ozias, X. Lei, B. Levant and U.S. Inc., Bridgewater, NJ and 2Pharmachem C. Klaassen. Pharmacology and Toxicology, KU Laboratories, Inc., Kearny, NJ. Medical Center, Kansas City, KS. #1982 CHRONIC TOXICITY EVALUATION OF #1989 N-3 PUFA DOCOSAHEXAENOIC ACID A CHARACTERIZED SOY ISOFLAVONE INHIBITION OF DEOXYNVALENOL- MIXTURE IN RATS. W. D. Johnson1, T. L. Horn1, INDUCED CREB PHOSPHORYLATION R. L. Morrissey2, I. M. Kapetanovic3, J. A. Crowell3 CORRELATES WITH DECREASED and D. L. McCormick1. 1IIT Research Institute, UPSTREAM AKT1 KINASE ACTIVITY. Y. Shi1, Chicago, IL, 2Pathology Associates, Chicago, IL and 2 and J. J. Pestka1, 2, 3. 1Food Science and Human 3National Cancer Institute, Bethesda, MD. Nutrition, Michigan State University, East Lansing, MI, 2Food Science and Human Nutrition, Michigan #1983 CHRONIC TOXICITY EVALUATION OF State University, East Lansing, MI and 3Center for A CHARACTERIZED SOY ISOFLAVONE Integrative Toxicology, Michigan State University, 1 1 MIXTURE IN DOGS. J. Harder , W. D. Johnson , East Lansing, MI. R. L. Morrissey2, I. M. Kapetanovic3, J. A. Crowell3 and D. L. McCormick1. 1IIT Research Institute, #1990 DOCOSAHEXAENOIC ACID CONSUMPTION Chicago, IL, 2Pathology Associates, Chicago, IL and MODULATES HOST RESPONSE TO 3National Cancer Institute, Bethesda, MD. ENTERIC REOVIRUS INFECTION IN THE MOUSE. E. Beli1, M. Li1, 3, 2, C. Cuff4 and J. Pestka1, #1984 EFFECTS OF SYNEPHRINE AND 3, 2. 1Food Science and Human Nutrition, Michigan CAFFEINE ON PHYSIOLOGICAL AND State University, East Lansing, MI, 2Department of CARDIOVASCULAR VARIABLES IN FEMALE Microbiology and Molecular Genetics, Michigan 1 1 SPRAGUE-DAWLEY RATS. P. Duffy , G. White , State University, East Lansing, MI, 3Center for 1 1 2 1 K. Wall , S. Appana , L. Pellicore and D. Hansen . Integrative Toxicology, Michigan State University, 1 Division of Genetic and Reproductive Toxicology, East Lansing, MI and 4Department of Microbiology National Center for Toxicological Research, and Immunology, West Virginia University, 2 Jefferson, AR and Division of Dietary Supplement Morgantown, WV. Programs and Compliance, Center for Food Safety and Applied Nutrition, College Park, MD. Sponsor: #1991 BUTYLATED HYDROXYTOLUENE M. Moore. CHEMOPREVENTION OF AFLATOXICOSIS IN TURKEYS IS DOSE-RELATED. J. A. #1985 EFFECT OF PHYLLANTHUS Guarisco, J. O. Hall and R. A. Coulombe. Graduate MADERASPATENSIS, A DIETARY Toxicology Program and Department of Veterinary SUPPLEMENT ON CISPLATIN INDUCED Sciences, Utah State University, Logan, UT. CLASTOGENICITY IN CULTURED HUMAN LYMPHOCYTES. P. Bommu, M. Nanjan, M. #1992 INDUCTION OF NEURAL TUBE DEFECTS Chandrasekar and B. Suresh. TIFAC CORE IN CD1 MICE BY INTRAPERITONEAL 1, in Herbal Drugs, J.S.S College of Pharmacy, EXPOSURE TO FUMONISIN B1 T. D. Burns Ootacamund, Tamilnadu, India. 2, R. T. Riley2, J. B. Gelineau-van Waes3 and K. A. Voss2. 1Pharmaceutical and Biomedical Sciences, #1986 THE ANTHOCYANIDIN DELPHINIDIN University of Georgia, Athens, GA, 2Toxicology and ACTS AS A CATALYTIC TOPOISOMERASE Mycotoxin Research, USDA-ARS, Athens, GA and I AND II INHIBITOR, SUPPRESSING 3Genetics, Cell Biology and Anatomy, University of THE DNA-DAMAGING PROPERTIES OF Nebraska Medical Center, Omaha, NE. TOPOISOMERASE POISONS IN-VITRO. D. Marko and J. Fritz. Institute of Applied Biosciences, #1993 EVIDENCE FOR INCREASED SPHINGOID University of Karlsruhe, Karlsruhe, Germany. BASE 1-PHOSPHATE LYASE ACTIVITY IN Sponsor: M. Metzler. CORN SEEDLINGS AFTER PROLONGED EXPOSURE TO FUMONISIN. L. D. Williams1, #1987 THE COMBINED EFFECT OF ISOFLAVONE 2, A. E. Glenn2, C. W. Bacon2, M. A. Smith1 and AND E2 ON VAGINAL OPENING OF FEMALE R. T. Riley2, 1. 1Environmental Health Sciences, 1, 2 1, 2 MICE. K. Takashima-Sasaki , H. Fukata , C. University of Georgia, Athens, GA and 2Toxicology 1, 2 1, 2, 3 1 Mori and M. Komiyama . Bioenvironmental and Mycotoxin Research Unit, USDA-ARS, Athens, Medecine, Graduate School of Medicine, Chiba GA. University, Chiba, Japan, 2Environmental Health Science Project for Future Generations, Graduate #1994 RNAI – MECHANISMS AND TOOLS FOR School of Medicine, Chiba University, Chiba, Japan TOXIN CONTROL IN ASPERGILLUS and 3Center for Environment, Health and Field SPECIES. E. A. Bolterstein1 and N. P. Keller2, 1. Sciences, Chiba University, Kashiwa, Japan. 1METC, University of Wisconsin, Madison, WI and 2Plant Pathology, University of Wisconsin, Madison, WI. Sponsor: J. Johnson. WEDNESDAY up-to-date information at www.toxicology.org 219 , 3 .
, 1, 2 1 , N. , N. , N. , N. 1 1 , M. 2 Human . 2 1 , V. V. , 1 , R. Clark R. , 3 L. Costa G. J. Jiang , J.
1 J. Jiang J. , A. N. A. N. , 1 , J. Xiao , J. Center for Free Center for Free and 1 1 1 . , J. Jiang , J. 1 1 , L. V. Basova V. , L. 1 Department of 2 , Q. Zhao , Q. Annual Meeting Annual Ctr for Free Radical & Ctr for Free 1 1 th , P. Kochanek P. , . 1 V. E. Kagan and V. 1 , Q. Zhao , Q. 2 1 , H. Bayir , Y. Tyurina Y. , 1 T. Kavanagh , T. 1 1 , Q. Zhao Q. , Neurology, Universtiy of Pitt, Pgh, Universtiy Neurology, 1 2 SOT's 45 SOT's V. E. Kagan and V. 2 V. Kagan and V. , A. A. Kapralov A. , , V. A. Tyurin A. V. , 2 1 1 , V. Tyurin V. , , C. White , C. , D. H. Waldeck H. , D. 1 2 3, 2 Department of Critical Care Medicine, of Pitt, Pgh, PA. Crit Care Med., Universtiy Y. Y. Tyurina Y. , Y. 3 3 , P. Wipf , P. 1 3 , X. Zhang X. , 1 Environmental and Occupational Health Sciences, Environmental EOH, Center for Free Radical and Antioxidant Antioxidant Radical and EOH, Center for Free PA. Pittsburgh, of Pittsburgh, University Chemistry, Chemistry, University of Pittsburgh, Pittsburgh, Pittsburgh, of Pittsburgh, University Chemistry, and PA Ritov A. Belikova H. Bayir University of Washington, Seattle, WA and WA Seattle, Washington, of University MITOCHONDRIAL TARGETING OF TARGETING MITOCHONDRIAL HEMIGRAMICIDIN S-PEPTIDYL- AGAINST PROTECTS NITROXIDES APOPTOSIS AND CARDIOLIPIN OXIDATION CELLS. IN MOUSE EMBRYONIC and PA Pittsburgh, of Pittsburgh, Health University AND UNFOLDING ACTIVITY PEROXIDASE C INDUCED BY OF CYTOCHROME APOPTOTIC IN ROLE CARDIOLIPIN: Vladimirov, A. Y. A. Belikova, N. SUGNALING. V. I. Basova, V. L. A. Kapralov, A. Osipov, A. N. Radical . Center for Free E. Kagan and V. Kurnikov of Pittsburgh, Health, University Antioxidant and PA. Pittsburgh, APOPTOSIS A NEW BIOMARKER OF EARLY CARDIOLIPIN OXIDATION. THE BRAIN: IN P. Fink P. A. Belikova S. DeKosky CEREBELLAR GRANULE CELLS. Giordano 1 Osipov 1 2 Radical and Antioxidant Health, Department of Antioxidant Radical and University and Occupational Health, Environmental PA, Pittsburgh, of Pittsburgh, Antioxidant Health, Env Occup Health, Universtiy Occup Health, Universtiy Health, Env Antioxidant of Pitt, Pgh, PA, P. K. Gill P. PA and PA Anatomy, Pharmacology and Forensic Medicine, and Forensic Pharmacology Anatomy, of Parma Medical School, Parma, Italy. University University of Pittsburgh, Pittsburgh, PA. Pittsburgh, of Pittsburgh, University APOPTOSIOS: IN LYSOCARDIOLIPINS C, WITH CYTOCHROME INTERACTIONS OF DISTRIBITION ASYMMETRY AND TBID Tyurin A. V. IN MITOCHONDRIA. OF DOMOIC CONCENTRATION LOW INDUCES MITOCHONDRIALLY (DA) ACID IN MOUSE DEATH APOPTOTIC MEDIATED
1:30 PM–4:30 PM 1:30 PM–3:00 PM (Continued) Annual Annual th #2002 #2004 #2005 1:30 PM to 4:30 PM Exhibit Hall CELL DEATH/APOPTOSIS POSTER SESSION: Ames, IA State University, Iowa Kanthasamy, Anumantha Chairperson(s): TX. Austin, Austin, at Texas of University Richburg, and John Displayed: Attended: Wednesday, March 8 March Wednesday, #2003 #2006 45
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. Meeting & ToxExpo & Meeting 1 . , M. 1 , D. , D. 1 , B. , B. 2 and 3 Health and M. Ema 1 USDA, USDA, 4 . and J. and J. 2 J. Vodela J. , C. 1 1 , J. Rine , J. 1 Chemistry, Chemistry, 2 , M. O’Keefe 1 and A. Lundebye and , E. Verdin , E. 2 1 USDA, Washington Washington USDA, King’s College College King’s 7 2 , C. Mao . USDA, Washington Washington USDA, 1 2 Residue Branch, USDA/ 1 L. Zhang USDA, Washington DC, DC, Washington USDA, . , G. Sales , R. Sutton 5 1 2 1 , 2 A. J. Olaharski A. J. Toxicology Unit, Departmentof Toxicology 2 , K. Tung , K. 1 H. Lantum and J. M. Maduabuchi and J. MCB, UC Berkeley, Berkeley, CA Berkeley, UC Berkeley, MCB, 2 2 USDA, Washington DC, DC. Washington USDA, 8 , D. Zheng , D. School of Public Health, UC Berkeley, Health, UC Berkeley, School of Public 2 USDA, Washington DC, DC, Washington USDA, 1 , C. Deyrup , J. Babiarz , J. 3 1 , J. A. Lin , J. 3 . 1 1 and H. Walker and H. Veterinary Medicine, National Chung-Hsing Veterinary 1 1 . Gladstone Institute, UCSF, San Francisco, CA. San Francisco, Gladstone Institute, UCSF, . 3 2 USDA, Washington DC, DC, Washington USDA, NIFES, Bergen, Norway and Norway NIFES, Bergen, P. Zervos P. Washington DC, DC, Washington Berkeley, CA, Berkeley, FSIS, Washington DC, DC, Washington FSIS, FAST IDENTIFICATION OF FIFTEEN FOOD- IDENTIFICATION FAST SPECIES BY ELECTROCHEMICAL MEAT PROFILING. CHROMATOGRAPHIC LIQUID DC, DC, 6 DC, DC and C. Chou Zen MAMMALIAN MODEL. C. Glover 1 St. London, London, United Kingdom. Sponsor: D. Clair Marshall and AND PHASE II-ENZYME INDUCERS ON AND PHASE II-ENZYME MAMMARY RAT ACRYLAMIDE-INDUCED Cho, Y. Takami, S. Imai, T. CARCINOGENESIS. National Institute of M. Hasumura and M. Hirose. Japan. Sponsor: Tokyo, Health Sciences, LEAD AND CADMIUM EXPOSURES FROM FROM AND CADMIUM EXPOSURES LEAD AND NON-CANNED BEVERAGES CANNED CONCERN. A PUBLIC HEALTH IN NIGERIA: Nigeria. Sponsor: Smith T. Environmental Laboratories, Eastman Kodak Co., Laboratories, Eastman Kodak Environmental and NY Rochester, HEALTH HAZARD ASSESSMENT FOR EGG HAZARD HEALTH . CFSAN, M. Bolger Assimon and P. S. ALLERGY. MD. Park, College USFDA, Pagan THE FLAVORING AGENT AGENT THE FLAVORING AN EPIGENETIC IS DIHYDROCOUMARIN INHIBITS SIRTUIN THAT TOXICANT DEACETYLASES. INHIBITORY EFFECTS OF ANTIOXIDANTS ANTIOXIDANTS EFFECTS OF INHIBITORY ASSESSMENT OF THE RISKS AND THE RISKS ASSESSMENT OF A METHYLMERCURY- BENEFITS OF SEAFOOD DIET CONTAMINATED FUNCTIONAL AN INTEGRATED USING A IN APPROACH TOXICOGENOMIC National Chung Hsing University, Taichung, Taiwan. Taichung, National Chung Hsing University, RESIDUE PROGRAM THE NATIONAL TOOL. FOOD SAFETY A (NRP)AS O. E. Orisakwe O. Hogstrand Pharmacology, Nnamdi Azikiwe University, Nnewi, Nnewi, University, Azikiwe Nnamdi Pharmacology, University, Taichung, Taiwan and Taiwan Taichung, University, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#1999 #1995 #2001 #1997
#1996 Program Description Description Program #1998 #2000
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2007 LENTIVIRAL MEDIATED EXPRESSION #2014 Z-VAD-FMK AND Z-FA-FMK RESCUE RAT OF THE CATALYTIC FRAGMENT OF PLEURAL MESOTHELIAL CELL FROM PKC DELTA IN THE SUBSTANTIA CADMIUM CHLORIDE INDUCE APOPTOSIS. NIGRA PROMOTES DOPAMINERGIC K. Mirchandani and J. M. Cerreta. PHS, St. John’s DEGENERATION: EVIDENCE FOR University College of Pharmacy and Allied Health PROAPOPTOTIC FUNCTION OF THE Professions, Jamaica, NY. Sponsor: L. Trombetta. OXIDATIVE STRESS SENSITIVE KINASE PKC DELTA IN PARKINSON’S DISEASE. H. #2015 CADMIUM INDUCES APOPTOSIS IN HUMAN Saminathan, Y. Yang, D. Zhang, V. Ananthram, A. OSTEOSARCOMA CELLS. K. G. Coonse, A. J. Kanthasamy and A. G. Kanthasamy. Department of Coonts, E. V. Morrison and S. J. Heggland. Biology, Biomedical Sciences, Iowa State University, Ames, Albertson College of Idaho, Caldwell, ID. Sponsor: IA. V. Garry. #2008 PROTEASOME INHIBITOR-INDUCED #2016 THE DEVELOPMENT OF AN IN VITRO APOPTOSIS IN DOPAMINERGIC NEURONAL MODEL FOR THE DETECTION AND CELLS IS MEDIATED BY A FEEDBACK EVALUATION OF DRUG-INDUCED 1 2 1 AMPLIFICATION OF MITOCHONDRIAL MYOPATHY. S. Boldt , E. Wu , S. Schomaker , G. 1 1 1 1 CASPASE CASCADE BY PKC DELTA. F. Sun, Boucher , A. Jakowski , R. Valdez and D. Amacher . 1 2 V. Anantharam, Y. Yang, A. Kanthasamy and A. G. WWSS, Pfizer, Inc., Groton, CT and Pharmacy, Kanthasamy. Iowa State Universuty, Ames, IA. Rutgers State University, Princeton, NJ. #2009 ROLE OF CASPASE-2 IN ETOPOSIDE- #2017 CHEMICALLY-INDUCED APOPTOSIS RESISTANT APAF1 KNOCKDOWN JURKAT IN FRESHLY-ISOLATED HUMAN 2 1 T-CELLS. P. Bu, E. E. Franklin and J. D. Robertson. HEPATOCYTES. D. Amacher , G. Chen and P. 1 1 Pharmacology, Toxicology and Therapeutics, MS Silber . In Vitro Technologies, Inc., Baltimore, MD 2 1018, University of Kansas Medical Center, Kansas and Pfizer, Groton, CT. City, KS. #2018 INVOLVEMENT OF NUR77 AND CELL #2010 DMBA-INDUCED APOPTOSIS OF BONE SIGNALING PATHWAYS IN TRIBUTYLTIN- MARROW B CELLS IS LIKELY INITIATED INDUCED APOPTOSIS IN MOUSE 3, 1 1, THROUGH A METABOLITE-DRIVEN, TESTICULAR CELLS. K. Lee and H. Jeong 2 1 MITOCHONDRIAL PATHWAY. J. K. Emberley1, . Pharmacy, Chosun University, Kwangju, South 2 J. J. Schlezinger2, H. Ryu2 and D. H. Sherr2. Korea, Research Center for Proteineous Materials, 1Microbiology, Boston University School of Chosun University, Kwangju, South Korea and 3 Medicine, Boston, MA and 2Environmental Health, Laboratory of Cell Biology, NHLBI, NIH, Boston University School of Public Health, Boston, Bethesda, MD. MA. #2019 ACTIVATION OF P53 IN TESTICULAR #2011 IDENTIFICATION OF MITOCHONDRIAL SPERMATOCYTES CONTRIBUTES TO PROTEIN TARGETS OF APOPTOSIS- THEIR SENSITIVITY TO UNDERGO FAS- 1 INDUCING ELECTROPHILES. H. L. Wong and MEDIATED APOPTOSIS. C. M. McKee and J. 2 1 D. C. Liebler. Biochemistry, Vanderbilt University, H. Richburg . Cell and Molecular Biology Graduate Nashville, TN. Program, The University of Texas at Austin, Austin, TX and 2College of Pharmacy, The University of #2012 MITOCHONDRIA MEDIATED APOPTOSIS Texas at Austin, Austin, TX. AND CELL CYCLE ARREST IN RAW264.7 CELLS WERE INDUCED BY THE #2020 CHARACTERIZATION OF TRAIL-INDUCED CYTOSTATIC COMPOUND PRODUCED TESTICULAR GERM CELL APOPTOSIS. J. DURING CO-CULTIVATION OF TWO H. Richburg and Y. Ye. College of Pharmacy, The INDOOR AIR MICROBES. P. Penttinen1, 2, University of Texas at Austin, Austin, TX. 2, 3 1 1 J. Pelkonen , K. Huttunen and M. Hirvonen . #2021 THE EFFECT OF POST MORTEM DELAY ON 1 Department of Environmental Health, National MARKERS OF APOPTOSIS IN THE RAT. C. 2 Public Health institute, Kuopio, Finland, University Scudamore and A. Scott. Covance Laboratories Ltd., 3 of Kuopio, Kuopio, Finland and Kuopio University Harrogate, United Kingdom. Sponsor: D. Everett. Hospital, Kuopio, Finland. Sponsor: M. Viluksela. #2013 AEROSOL DELIVERY OF GLUCOSYLATED POLYTHEYLENIMINE/PROGRAMMED CELL DEATH 4 (PDCD4) COMPLEX REGULATED APOPTOSIS, CELL CYCLE AN IN LUNGS OF AP-1 LUCIFERASE MICE. S. Hwang and M. Cho. Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea. WEDNESDAY up-to-date information at www.toxicology.org 221 , R. J. J. and , X. 1 . M. Sens 1, 3 E. M.
W. E. and W. H. 1 Microbiology, Microbiology, . 1 . 1 Annual Meeting Annual th J. LaPres and J. 2 I. Chou GENE CONFERRING , B. Leon-Chavez , B. 1 and 2 Cdm SOT's 45 SOT's Graduate Program in Genetics, Graduate Program . Environmental Nebert. Environmental W. and D. 2 A. Vengellur A. Labortorio de Investigaciones Quimico Quimico Labortorio de Investigaciones 1 , Y. Zhao Y. , . . Pathology, University University . Pathology, and S. H. Garrett , X. Zhou, A. Albrecht, A. S. Somji, X. Zhou, , K. Rubin 2 T. P. Dalton P. T. L. He, S. Girigashanker, 2 1 , L. He , -/- MOUSE EMBRYONIC α -/- MOUSE EMBRYONIC Biochemistry, Boston University School of Boston University Biochemistry, 2 W. Li , W. 1 Toxicology, Bristol-Myers Squibb Pharmaceutical Bristol-Myers Toxicology, East State University, Michigan Biochemistry, Center, Toxicology Safety and National Food Michigan State University, East Lansing, MI and East Lansing, State University, Michigan Boston University School of Medicine, Boston, MA Boston University D. A. Sens D. FIBROBLAST CELLS SHOW INCREASED CELLS SHOW FIBROBLAST CADMIUM-INDUCED TO SUSCEPTIBILITY TOXICITY. Health, University of Cincinnati Medical Center, Center, of Cincinnati Medical Health, University Kayama. Horiguchi, E. Oguma, H. Uno and F. Medicine, Center for of Environmental Division Achanzar NJ. Brunswick, Research Institute, New A MODEL AS CELL LINE THE RWPE-1 EPITHELIUM. SYSTEM FOR PROSTATE MI. East Lansing, State University, Michigan MAPKS SIGNALLING INTRACELLULAR HEPG2 TREATED IN CDCL2 PATHWAYS C. Escobar, V. Souza, E. Hernandez, L. V. CELLS. C. Escobar, E. Gómez-Quiroz, L. Bucio and M. Gutierrez- Autonoma Ruiz. Health Science, Universidad Mexico. D.F., Meropolitana, Mexico, Cincinnati, OH. CADMIUM INDUCES TO EXPOSURE ACUTE OF GRANULOCYTE PRODUCTION ALONG FACTOR COLONY-STIMULATING IN MICE. WITH NEUTROPHILIA Community Medicine, Jichi Medical School, Yoshida T. Japan. Sponsor: Tochigi, 2 K. Singh, HIF1 1 Lansing, MI, 3 GLUTATHIONE (GSH) HOMEOSTASIS (GSH) HOMEOSTASIS GLUTATHIONE CELL INJURY AND CADMIUM-INDUCED Chou D. LUNG FIBROBLASTS. IN RAT Du and Medicine, Boston, MA. TRANSPORT OF CHARACTERIZATION AND SUBCELLULAR PROPERTIES IMPORTANT AN OF ZIP8, LOCALIZATION CADMIUM. OF TRANSPORTER ROGUE M. Reed of Health, University Nebert. Environmental W. D. Cincinnati, OH. Cincinnati Medical Center, CHROMOSOME ARTIFICIAL BACTERIAL THAT TRANSGENESIS CONFIRMS (BAC) THE Slc39a8 IS Dalton T. P. P. T. Wang, CADMIUM. B. TO SENSITIVITY INHIBITORY EFFECT OF THIONEIN EFFECT OF INHIBITORY ACTIVITY. A ON RIBONUCLEASE of North Dakota, Grand Forks, ND. of North Grand Forks, Dakota, Brambila Clinicas, University of Puebla, Puebla, Mexico and Mexico Puebla, of Puebla, Clinicas, University
(Continued) Annual Annual th #2033 #2035 #2031 #2028 #2029 #2030 #2032 #2034 45 222 Meeting & ToxExpo & Meeting
2 M. 1 , P. C. , P. , . 1 2 H. M. P. and M. P. 3 , D. , D. 2
Fac. of Fac. J. Liu , J. 1 1 . , W. Zhang W. , 1 1 Department of Pharmacology, Pharmacology, 2 1 J. Edwards J. . , M. Svensson , H. Ke 1 Molecular Biology, Molecular Biology, 2 1 2 D. W. Nebert W. and D. , J. Boos , J. 1 , J. D. Peuler D. , J. W. Qu W. , M. M. Webber , M. M. 1 2 LPC, NIEHS, Research 2 and S. Himeno LCC, NCI at NIEHS, Research J. Liu J. 2 1 . Environmental medicine, Umea Environmental 1 1 . , D. Gunnarsson , D. T. P. Dalton P. , T. 2 1 NIEHS, Research Triangle Park, NC and Park, Triangle NIEHS, Research W. C. Prozialeck and W. M. Satoh LCC, NCI at NIEHS, Research Triangle Triangle LCC, NCI at NIEHS, Research J. E. French , J. 2 2 1 1 L. He , 1 . 1 , E. Diamantakos 1 Michigan State University, East Lansing, MI. East Lansing, State University, Michigan National Cancer Institute, NIEHS, Research Park, NC, Park, University, Umea, Sweden and Umea, Sweden University, Midwestern University, Downers Grove, IL and Grove, Downers University, Midwestern CADMIUM-INDUCED DISRUPTION OF DISRUPTION CADMIUM-INDUCED ADHESION IS CELL TUBULE PROXIMAL OF WITH REDISTRIBUTION ASSOCIATED AND LOSS ADHESION MOLECULES CELL OF EPITHELIAL POLARITY. Waalkes Environmental Health, University of Cincinnati Health, University Environmental Cincinnati, OH. Medical Center, BETWEEN INTERACTION PRONOUNCED TESTICULAR AND ZINC ON CADMIUM F2ALPHA (PGF2) LEVELS PROSTAGLANDIN EFFECTS OF TO – MECHANISM RELATED TISSUES. CADMIUM ON REPRODUCTIVE P. Waalkes P. 3 M. P. Waalkes and M. P. NC. Park, Triangle IN CADMIUM- RESISTANCE APOPTOTIC TRANSFORMED HUMAN PROSTATE EPITHELIAL CELLS. Broderick and G. Selstam Fujishiro Japan. Slc39a8 GENE OVEREXPRESSION CADMIUM-INDUCED TO SENSITIZES MICE Schneider, S. N. DYSFUNCTION. RENAL Wang, B. Lamar 2 NC. Park, Triangle GENE EXPRESSION PROFILES OF CADMIUM-RESISTANT NULL CELLS. METALLOTHIONEIN Bunri Tokushima Pharmaceutical Sciences, Japan and Tokushima, University, Umea University, Umea, Sweden. Umea University, OF ANALYSIS GENOMIC ZINC EXPOSURE IN HEPATOPROTECTIVE RATS. AND MICE G. F. Nordberg F. G. Hygienics, Gifu Pharmaceutical University, Gifu, Hygienics, Gifu Pharmaceutical University, Triangle Park, NC and Park, Triangle
45th Annual Meeting and ToxExpo and Meeting Annual 45th
1:30 PM–4:30 PM 3:00 PM–4:30 PM
#2022 #2025 #2027 #2024 #2023 Attended: : Michael Waalkes, NIEHS, Research Triangle Park, NC Park, Triangle Research NIEHS, Waalkes, Chairperson(s): Michael ND. Forks, North Dakota, Grand of University and Scott Garrett, Displayed: Exhibit Hall AND ZINC, TOXICITY, CD POSTER SESSION: METALLOTHIONEIN Wednesday, March 8 March Wednesday, 1:30 PM to 4:30 PM
#2026 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2036 MICROARRAY ANALYSIS OF CADMIUM Wednesday, March 8 RESPONSIVE TRANSCRIPTION IN 1:30 PM to 4:30 PM 1 CAENORHABDITIS ELEGANS. Y. Cui , W. Exhibit Hall A. Boyd2, S. J. McBride1 and J. H. Freedman1, 2. 1 Nicholas School of the Environment and Earth POSTER SESSION: METALS TOXICOLOGY II Sciences, Duke University, Durham, NC and 2Laboratory of Molecular Toxicology, ETP, DIR, Chairperson(s): Steve Roberts, University of Florida, Gainesville, FL and NIEHS, Research Triangle Park, NC. Iih-Nan Chou, Boston University, Boston, MA.
#2037 SELECTIVE OVER-EXPRESSION Displayed: 1:30 PM–4:30 PM OF DNMT3B IS SUFFICIENT FOR GLOBAL AND GENE SPECIFIC DNA Attended: 1:30 PM–3:00 PM HYPERMETHYLATION DURING CADMIUM- #2043 BEHAVIOR OF BISMUTH ADMINISTERED INDUCED MALIGNANT TRANSFORMATION. INTRATRACHEALLY TO RATS. A. Shinohara1, L. Benbrahim-Tallaa1, J. Coppin1, M. M. Webber2 M. Chiba1, H. Sato2, K. Omae3, M. Okamoto4, and M. P. Waalkes1. 1LCC, NCI at NIEHS, Research K. Serizawa4 and Y. Inaba1. 1Department of Triangle Park, NC and 2Michigan State University, Epidemiology and Environmental Health, Juntendo East Lansing, MI. University School of Medicine, Tokyo, Japan, #2038 THE UNIQUE N-TERMINAL SEQUENCE OF 2Environmetal Health Science, Tohoku University MT-3 IS REQUIRED FOR THE APOPTOTIC Graduate School of Medicine, Sendai, Japan, TO NECROTIC SHIFT IN RESPONSE TO 3Department of Preventive Medicine and Public CADMIUM IN MT-3 TRANSFECTED CELLS. Health, Keio University, School of medicine, D. A. Sens, S. Somji, M. Sens and S. H. Garrett. Tokyo, Japan and 4Production Engineering Research Pathology, University of North Dakota, Grand Forks, Laboratory, Hitachi Ltd., Yokohama, Japan. ND. #2044 UBIQUITINATION AND DEGRADATION OF #2039 EXPRESSION OF METALLOTHIONEINS IN EUKARYOTIC TRANSLATION INITIATION HUMAN PROSTATE TUMORS: EVIDENCE FACTOR 4E RESULT IN TOXICITY AND OF POST-TRANSCRIPTIONAL CONTROL. DEATH IN HELA CELLS EXPOSED TO S. H. Garrett, R. K. Singh, X. Zhou, M. Sens, S. POTASSIUM DICHROMATE. S. Othumpangat Somji and D. A. Sens. Pathology, University of North and P. Joseph. Health Effects Laboratory Division, Dakota, Grand Forks, ND. NIOSH, Morgantown, WV. #2040 STUDIES ON BLOOD METALLOTHIONEIN #2045 ALPHA-TOCOPHEROL PREVENTS AS A BIOMARKER OF TISSUE CHANGES ON THE CLAUDIN-2 METALLOTHIONEIN EXPRESSION. J. Shen, AND OCCLUDIN EXPRESSION AND J. Liu and M. P. Waalkes. LCC, NCI at NIEHS, LOCALIZATION PATTERN, INDUCED BY Research Triangle Park, NC. POTASSIUM DICHROMATE IN MURINE KIDNEY. L. Arreola-Mendoza1, J. L. Reyes2, M. E. #2041 DOWN REGULATION OF MT-3 EXPRESSION Mendoza-Garrido2, D. Martin2, M. C. Namorado2, IN HUMAN PROXIMAL TUBULE CELLS E. I. Sanchez2, B. Reyes2 and L. M. Del Razo1. DECREASES DOME FORMATION AND 1Toxicology, Cinvestav, Mexico D.F., Mexico and ATTENUATES APOPTOSIS. S. Somji, S. 2Physiology & Biophysics, Cinvestav, Mexico D.F., H. Garrett, M. Sens and D. A. Sens. Pathology, Mexico. University of North Dakota, Grand Forks, ND. #2046 CHROMIUM (VI) INDUCES ANTIOXIDANT #2042 OVER EXPRESSION OF GENE HO-1 BY ACTIVATING THE CNC BZIP METALLOTHIONEIN IN HUMAN BLADDER TRANSCRIPTION FACTOR NRF2. X. He1, CANCER IS CORRELATED TO POOR G. Lin1, J. Zhang2 and Q. Ma1. 1Receptor Biology PROGNOSIS. X. Zhou, M. Sens, S. Somji, S. H. Laboratory/TMBB, NIOSH, Morgantown, WV and Garrett and D. A. Sens. Pathology, University of 2Harvard University, Boston, MA. North Dakota, Grand Forks, ND. #2047 CHROMIUM(VI) REQUIRES HISTONE DEACETYLASE TO INDUCE INTERFERON- STIMULATED GENES. A. A. Nemec, K. A. O’Hara, L. R. Klei, R. J. Vaghjiani and A. Barchowsky. Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. #2048 COMET ASSAY ANALYSIS OF DNA DAMAGE INDUCED BY CHROMIUM PICOLINATE. A. Lencinas, C. S. Asplund, V. H. Coryell and D. M. Stearns. Department of Chemistry, Northern Arizona University, Flagstaff, AZ. WEDNESDAY up-to-date information at www.toxicology.org 223
, 2 1, , A. , , 2 1 , 2 . , E. Jesus 2 A. L. Weiss A. L. I. Biologia Biologia 1 . Environmental Environmental 1 1 , J. Ordonez L , J. . , P. Aley , P. Environmental Environmental 2 , G. Martinez- 1 2, 1 1 , M. C. Ghosh 1, 2 , G. Pinon-Zarate Environmental Environmental . 1 1 2 1 Annual Meeting Annual th . LCC, NCI at NIEHS, T. I. Fortoul and T. 1 , P. Diaz-Bech , P. D. R. Crooks D. 1 M. Avila-Costa M. SOT's 45 SOT's R. J. Jaeger and R. J. 3 D. R. Smith and D. 2 , L. Colin-Barenque 2 , V. Rodriguez-Lara V. , 1 M. P. Waalkes and M. P. , V. Delgado V. , 1 Cell Biology and Metabolism Branch, NICHD, and Metabolism Branch, NICHD, Cell Biology , J. Caravanos , J. CUNY, School of Health Sciences, Hunter College Mexico. Edo Mex, Mexico, Neurociencias, UNAM, STUDIES ON THE ROLE OF THE ROLE STUDIES ON AND SYNUCLEIN METALLOTHIONEIN BODY IN LEAD-INDUCED INCLUSION A. R. Qu, R. Cooper, W. Zuo, P. FORMATION. Goyer Medicine Inc., Westwood, NJ, NJ, Westwood, Medicine Inc., Levy Gutierrez V. Gutierrez Mussali P. Bethesda, MD. New York. New NEW ORLEANS: PRE-KATRINA OF LEAD AND SYNERGY ACCUMULATION AND CHILDREN’S HEALTH. AND MERCURY and Mexico D.F., Mexico, UNAM, Tisular, Celular y ACONITASE EFFECTS OF MANGANESE ON A GABAERGIC IN REGULATION AND IRON Department Pharmacology/Toxicology, Mich State Department Pharmacology/Toxicology, East Lansing, MI. University A NOVEL GRIT: ROADWAY LEAD IN URBAN AND ITS IMPLICATION. SOURCE 2 D. K. Atchison, P. J. Cobbett, J. Atchison, P. K. MUSCLE CELLS. D. Atchison D. and W. Fink R. K. Hajela, G. D. 2 3 Manuel and C. Alston, J. S. H. Mielke, E. Powell, Gonzales. Basic Pharmaceutical Sciences, Xavier Orleans, LA. New University, AND CELL DEATH IMPAIRMENT MOTOR AND NIGRA COMPACTA IN SUBSTANTIA AFTER MANGANESE CORPUS STRIATUM INHALATION. M. Rojas-Lemus 2 CELL MODEL. J. C. E. Gato and J. W. EXPRESSED GENES. University, Michigan Western Means. Chemistry, Kalamazoo, MI. ON SPERM ALTERATION LEAD EJACULATION. AT CHROMATIN EFFECTS OF LEAD ON L-TYPE CALCIUM A7R5 SMOOTH CHANNEL FUNCTION IN Research Triangle Park, NC. Park, Triangle Research LEAD PROLONGED AND ELEVATED LEADS 344 RATS EXPOSURE IN FISHER DIFFERENTIALLY MARKED HEPATIC TO UC Santa Cruz, Santa Cruz, CA and Toxicology, Hernandez-Ochoa, G. Martinez-Aguilar and B. Section, CINVESTAV, Toxicology . Quintanilla-Vega Mexico. D.F., City, Mexico Medicine, New York University, New York and York New University, York Medicine, New T. A. Rouault T.
(Continued) Annual Annual th #2055 #2060 #2062 #2059 #2061 #2057 #2056 #2058 45 224 Meeting & ToxExpo & Meeting
2 . , 2 , G. 1 and H. 4 , S. Park LBNL, and L. E. 1 3 1 Institute for 2 , L. Alex , L. 1 , K. Blennow 1 Nutritional Sciences Department M. Cho 1 4 , . 1 3 Department.Public Health/ Materials Chemistry D. M. Tessier M. D. 5 3 Inst.Env.Med., Karolinska Inst.Env.Med., 3 , J. Kim , J. Department Clinical Chemical Biology Laboratory, Laboratory, Chemical Biology 1 2 2 and A. Adam A. and Biochemistry, Stanford University University Stanford Biochemistry, M. M. Nordberg K. yu 1 2 , M. Eriksdotter-Jonhagen 3 Laboratory of Toxicology, College of College Toxicology, Laboratory of 1 . 3 School of Public Health, University of University Health, School of Public Inst. Env. Med., Karolinska Institutet, Med., Karolinska Institutet, Inst. Env. 1 1 . . 2 5 C. Vulpe , C. 2 Laboratory, School of Chemistry, Seoul National Seoul School of Chemistry, Laboratory, Seoul, South Korea. University, LEAD ENHANCED PROCOAGULANT THROUGH MEDIATED ACTIVITY EXPOSURE PHOSPHATIDYLSERINE IN HUMAN ERYTHROCYTES: TO FACTOR A CONTRIBUTING Shin, Noh, J. DISEASE. J. CARDIOVASCULAR of Chung. College Bae, K. Lim and J. S. Chung, O. Seoul, South Seoul National University, Pharmacy, Korea. and J. Lee and J. School of Chemistry, Seoul National University, Seoul National University, School of Chemistry, and Seoul, South Korea A549 CELLS. Neurotec/Clinical Geriatrics, Karolinska Institutet, Neurotec/Clinical Geriatrics, Karolinska Institutet, and Stockholm, Sweden Basun Neuroscience/Experimental Neuroscience, Gothenborg, Academy/university Sahlgrenska Sweden, Gothenborg, Guri AND NICKEL IN HUMAN LUNG AND NICKEL IN HUMAN EPITHELIAL CELLS. IL and Illinois Chicago, Chicago, LOSS OF REV3 PROTECTS AGAINST AGAINST LOSS OF REV3 PROTECTS CEREVISIAE. IN S. CR(VI) MUTAGENESIS The George and Physiology, Pharmacology Washington, Medical Center, University Washington DC. BY OF MAP KINASES ACTIVATION MANGANESE CHROMIUM, HEXAVALENT and Toxicology, University of California, Berkeley, of California, Berkeley, University Toxicology, and CA, Berkeley, Systems Biology, University of Washington, Seattle, Seattle, Washington, of University Systems Biology, WA. YEAST USING IN FITNESS PROFILING ANALYSIS DELETION PARALLEL THE IN IDENTIFIES GENES INVOLVED AND IRON- COPPER AGAINST RESPONSE Jo J. W. TOXICITY. INDUCED School of Medicine, Stanford, CA and School of Medicine, Stanford, Veterinary Medicine, Seoul National University, Seoul National University, Medicine, Veterinary Seoul, South Korea, Institutet, Stockholm, Sweden, Institutet, Stockholm, Sweden, Geriatrics, University Uppsala, Uppsala, Sweden. Uppsala, Uppsala, Geriatrics, University OF MAGNETIC CELLULAR UPTAKE THROUGH IS MEDIATED NANOPARTICLE IN ENDOCYTOSIS ENERGY-DEPENDENT , J. L. Fornsaglio and S. R. Patierno L. Fornsaglio , J. O’Brien J. T. N. Johansson N. Stockholm, Sweden, Stockholm, Sweden, Berkeley, CA. Berkeley, AND PROTEIN IRON ZINC, COPPER, FLUID IN MARKERS IN CEREBROSPINAL AND NORMAL ALZHEIMER’S DISEASE COGNITION. Pascal 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#2051 Program Description Description Program #2053 #2052
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2063 FINE-PARTICLE MN AND OTHER METALS #2070 90-DAY ORAL TOXICITY OF SODIUM LINKED TO THE INTRODUCTION OF MMT TUNGSTATE IN SPRAGUE-DAWLEY RATS. INTO GASOLINE IN SYDNEY, AUSTRALIA: G. A. Parker1, 2, P. A. Beall3 and W. C. McCain3. RESULTS OF A NATURAL EXPERIMENT. 1Biotechnics, Inc., Hillsborough, NC, 2Pathology, D. Cohen2, B. Gulson1, M. Davis3, E. Stelcer2, D. WIL Research Laboratories, Ashland, OH and Garton2, O. Hawas2 and A. Taylor1. 1Graduate School 3Toxicology, U.S. Army Center for Health Promotion of the Environment, Macquarie University, Sydney, and Preventive Medicine, Aberdeen Proving Ground, NSW, Australia, 2ANSTO, Sydney, NSW, Australia, MD. 3U.S. EPA, Research Triangle Park, NC and 4Psychology, Macquarie University, Sydney, NSW, #2071 BLOOD URANIUM CONCENTRATION AS Australia. A BIOMARKER OF HUMAN EXPOSURE TO DEPLETED URANIUM (DU) IN GULF #2064 MANGANESE DISTRIBUTION IN PRIMATE WAR I VETERANS WITH EMBEDDED TISSUES AFTER WELDING FUME FRAGMENTS. K. S. Squibb1, T. Todorov2, J. EXPOSURE. I. Yu1, J. Sung1, C. Kim2, S. Yang3, Centeno2, S. Engelhardt1 and M. McDiarmid1. H. Chung4, H. Khang3, J. Park5, E. Park4, J. Heo2, 1University of Maryland School of Medicine, Y. Chung1, J. Han1 and J. Lee1. 1Laboratory Baltimore, MD and 2Armed Forces Institute of of Occupational Toxicology, OSRHI/Korean Pathology, Washington, DC. OSHA, Daejeon, South Korea, 2Korea Institute of Toxicology, Daejeon, South Korea, 3Department #2072 INDICATIONS FOR SURGICAL REMOVAL of Radiology, Eulji University, Daejeon, South OF DEPLETED URANIUM (DU) SHRAPNEL 1, Korea, 4Department of Preventive Medicine, Sung IN GULF WAR I VETERANS. M. McDiarmid 2 1 2 1 Kyun Kwan University, Suwon, South Korea and , S. Engelhardt and K. S. Squibb . Department of 5Department of Preventive Medicne, Chung Ang Veterans’ Affairs Medical Center, Baltimore, MD 2 University, Seoul, South Korea. and UM School of Medicine, Baltimore, MD. #2065 CHANGES IN MN AND PB IN THE #2073 EFFECT OF ORGANIC ACID LIGANDS 1 ENVIRONMENT AND YOUNG CHILDREN ON URANIUM(VI) TOXICITY. C. J. Kuehl , 1 2 1 ASSOCIATED WITH THE INTRODUCTION V. H. Coryell , R. C. Lantz and D. M. Stearns . 1 OF MMT IN GASOLINE. B. Gulson1, K. Mizon1, Department of Chemistry, Northern Arizona 2 M. Korsch2, H. Louie5, M. Wu5, J. Stauber3, J. Davis4 University, Flagstaff, AZ and Cell Biology and and A. Taylor1. 1Grad School of Environment, Anatomy, University of Arizona, Tucson, AZ. Macquarie University, Sydney, NSW, Australia, #2074 URANIUM INHIBITS THE BINDING OF 2 3 CSIRO, Sydney, NSW, Australia, CSIRO, Sydney, TRANSCRIPTIONAL REGULATORS TO 4 NSW, Australia, EPA, Research Triangle Park, NC DNA. R. Lantz1, D. J. Segal2 and D. M. Stearns3. 5 and AGAL, Sydney, NSW, Australia. 1Cell Biology and Anatomy, University of 2 #2066 DEMETHYLATION OF METHYLMERCURY Arizona, Tucson, AZ, Medical Pharmacology and 3 IN PRIMARY CULTURES OF CEREBELLAR Toxicology, UC Davis, Davis, CA and Chemistry NEURONS AND ASTROCYTES. T. Syversen1, and Biochemistry, Northern Arizona University, E. Kummeneje1 and M. Aschner2. 1Department of Flagstaff, AZ. Neuroscience, Norwegian University of Science and #2075 DETERMINATION OF VANADIUM TISSUE 2 Technology, Trondheim, Norway and Department CONCENTRATIONS IN BRAIN, KIDNEY, of Pediatrics, Vanderbilt University Medical Center, LIVER, LUNG, TEETH AND TESTES AFTER Nashville, TN. DIFFERENT EXPOSURE TIMES. T. I. Fortoul1, 2 3 3 #2067 ACCELERATED URINARY EXCRETION M. Avila-Costa , L. Saldivar , G. Espejel-Maya , L. 2 1 OF METHYLMERCURY FOLLOWING Coli-Barenque , P. Bizarro-Nevarez , P. Mussali- 1 1 1 ADMINISTRATION OF ITS ANTIDOTE N- Galante , V. Rodriguez-Lara , G. Pinon-Zarate , G. 1 1 1 ACETYLCYSTEINE REQUIRES Mrp2/Abcc2, Martinez-Levy , M. Rojas-Lemus and V. Delgado . 1 THE APICAL MULTIDRUG RESISTANCE- Biologia Celular y Tisular, Facultad de Medicina, 2 ASSOCIATED PROTEIN. M. S. Madejczyk, T. A. UNAM, Mexico City, Mexico, NEUROCIENCIAS, Simmons-Willis and N. Ballatori. Environmental FES IZTACALA, EDO. MEXICO, Mexico and 3 Medicine, University of Rochester School of FAC. QUIMICA, UNAM, MEXICO CITY, Mexico. Medicine, Rochester, NY. #2076 GENOTOXIC POTENTIAL OF INHALED 1 #2068 INTERFERENCE OF NICKEL ON IRON VANADIUM ON MOUSE TESTES. P. mussali , 2 2 HOMEOSTASIS. H. Chen, T. L. Davidson, G. M. Avila-Costa , L. Colin-Barenque , P. Bizarro- 1 1 3 Kang and M. Costa. Department of Environmental Nevares , T. Fortoul and E. Tovar-Sanchez . 1 Medicine, New York University, Tuxedo, NY. Biologia celular y tisular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, #2069 CARCINOGENIC AND TOXICOLOGICAL 2Departamento de Neurociencias, Universidad EFFECTS OF EMBEDDED TUNGSTEN AND Nacional Autonoma de Mexico, Mexico City, TUNGSTEN ALLOYS. L. E. Roszell, B. Paulus Mexico and 3Centro de educacion ambiental e and G. J. Leach. U.S. Army CHPPM, Aberdeen investigacion Sierra de Huautla, Universidad Proving Ground, MD. Autonoma de Estado de Morelos, Cuernavaca, Morelos, Mexico. WEDNESDAY up-to-date information at www.toxicology.org 225
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1:30 PM–4:30 PM 3:00 PM–4:30 PM (Continued) Annual Annual th #2083 #2084 1:30 PM to 4:30 PM Exhibit Hall BIOASSAY CARCINOGENESIS POSTER SESSION: NY Valhalla, Medical College, York New Williams, Chairperson(s): Gary CA. Angeles, Los of Southern California, Landolph, University and Joseph Displayed: Attended: #2087 #2085 Wednesday, March 8 March Wednesday, #2086 45 226 . S. Meeting & ToxExpo & Meeting
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1 , A. M. Levine , 2 . 1 , J. W. Neilson W. , J. 1 E. P. Hines and E. P. 2 , AND Cr , K. S. Squibb , 2+ H. M. Korashy Department of Soil, Water and Water Department of Soil, , Cd , 2 3+ , M. Yellowhair , M. , B. Heidenfelder , B. 1 3 , J. E. Gallagher , J. . pathology, University of University A. Sens. pathology, and D. A. J. Gandolfi and A. J. 4 2 J. L. Powell , J. DESE, UNC, Chapel Hill, NC and DESE, UNC, Chapel Hill, 3 J. L. Rayner J. Pharmacology & Toxicology, University of Arizona, of University Toxicology, & Pharmacology AZ and Tucson, C. K. Begay H. Garrett Faculty of Pharmacy & Pharmaceutical Sciences, Faculty Canada. AB, Alberta, Edmonton, of University AND POST- TRANSCRIPTIONAL MECHANISMS TRANSCRIPTIONAL OF THE MODULATION IN INVOLVED As Cyp1a1 BY ND. north Grand Forks, dakota, MIXTURES EFFECTS OF METAL VITRO IN A. Potnis, 264.7 MONOCYTES. P. ON RAW J. Mitkus J. ARSENITE OR CADMIUM. MECHANISMS. Alberta, Edmonton, of El-Kadi. University and A. O. Canada. AB, AND CADMIUM ARSENITE THE EFFECT OF WITH TRANSFORMED CELLS ON UROTSA Environmental Science, University of Arizona, of Science, University Environmental AZ. Tucson, THE NAD(P)H: REGULATE METALS HEAVY 1 ( OXIDOREDUCTASE QUINONE NC, M. Maier COMPARISON OF METALS IN HUMAN OF METALS COMPARISON TRACE AND URINE USING MILK ANALYSES. MULTIELEMENT Iordanidis Human Studies Division, U.S. EPA, Chapel Hill, Chapel EPA, U.S. Human Studies Division, Group, Monroeville, PA. Group, Monroeville, EVALUATION TOXIC FOR ASSAY AN (E.G. TOXICANTS OF BIOAVAILABLE A THE AND URANIUM) USING ARSENIC BIOSENSOR. LUMINESCENT BACTERIAL NHEERL, Reproductive Toxicology Division, U.S. U.S. Division, Toxicology NHEERL, Reproductive NC, Park, Triangle Research EPA, GENE EXPRESSION THROUGH BOTH AHR- BOTH THROUGH GENE EXPRESSION TRANSCRIPTIONAL AND NRF2-MEDIATED UM School of Medicine, Baltimore, MD. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#2078 Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2088 HEMANGIOSARCOMAS INDUCED IN MICE #2095 CARCINOGENICITY STUDIES OF BY N-(4-HYDROXYPHENYL) RETINAMIDE. MURAGLITAZAR, A DUAL PPAR ALPHA J. A. Crowell1 and E. I. Goldenthal2. 1Division AND GAMMA AGONIST, IN MICE AND RATS. of Cancer Prevention, National Cancer Institute, T. Sanderson1, M. Dominick1, B. Schilling1, C. R. Bethesda, MD and 2MPI Research, Mattawan, MI. Waites1, D. Minnema2, R. Voelker2 and B. Ulland2. 1Bristol-Myers Squibb, Mt. Vernon, IN and 2Covance #2089 PRELIMINARY EVIDENCE OF Laboratories, Vienna, VA. UROLITHIASIS WITH MURAGLITAZAR- RELATED URINARY BLADDER CARCINOGENESIS IN MALE RATS. S. Wednesday, March 8 Tannehill-Gregg1, M. Cano2, L. Tomlinson1, 1:30 PM to 4:30 PM S. Cohen2, T. Sanderson1, B. Schilling1 and M. Exhibit Hall Dominick1. 1Bristol-Myers Squibb, Mt. Vernon, IN and 2University of Nebraska Medical Center, POSTER SESSION: MALE REPRODUCTIVE TOXICITY Omaha, NE. EVALUATIONS #2090 RESULTS OF 2-YEAR CARCINOGENICITY Chairperson(s): Aramandla Ramesh, Meharry Medical College, Nashville, EVALUATIONS OF PRAMLINTIDE IN MICE TN and Paul Foster, NIEHS, Research Triangle Park, NC. AND RATS. R. Hiles1, 2. 1CRHiles Consulting, Butler, TN and 2Amylin Pharmaceuticals, Inc., San Displayed: 1:30 PM–4:30 PM Diego, CA. Attended: 1:30 PM–3:00 PM #2091 CARCINOGENICITY VARIATION OF P- #2096 INFLUENCE OF SUBCHRONIC INHALED CRESIDINE WHILE USED AS A POSITIVE BENZO(A)PYRENE ON MALE FERTILITY CONTROL CHEMICAL IN THE P53 MOUSE INDICES OF F-344 RATS. A. RAMESH1, D. SHORT-TERM CARCINOGENICITY TEST Lunstra2, M. S. Niaz3, F. Inyang3, D. B. Hood1 and 1 1 1 MODEL. Y. Wang , P. Miller , B. Bassett , S. A. E. Archibong3. 1Biomedical Sciences, Meharry 1 1 2 1 Manetz , G. Wolfe and A. Purmal . Gene Logic Inc., Medical College, Nashville, TN, 2Meat Animal 2 Gaithersburg, MD and Panacos Pharmaceuticals, Research Center, USDA, Nebraska and 3Obstetrics 134 Coolidge Avenue, MA. & Gynecology, Meharry Medical College, #2092 ALTERNATIVE METHODS FOR Nashville, TN. CARCINOGENICITY TESTING: VALIDATION #2097 DIISOBUTYL PHTHALATE HAS OF THE P53 +/- MODEL. C. Banks, A. Adamou COMPARABLE ANTI-ANDROGENIC and L. Chouinard. Toxicology, Charles River EFFECTS IN RAT FETAL TESTIS TO Laboratories Preclinical Montréal, Senneville, QC, DIBUTYL PHTHALATE. M. Dalgaard, J. Borch, Canada. M. Petersen and A. Vinggaard. Department of #2093 A TRANSOMIC BIOMARKER COMPARISON Toxicology, Danish Institute for Food and Veterinary FOR PREDICTING TWO-YEAR RODENT Research, Soeborg, Denmark. Sponsor: E. Gray. 1 1 CANCER BIOASSAYS. R. S. Thomas , L. J. Pluta , #2098 NF- B ACTIVATION ELICITED BY IONIZING 1 2 2 κ T. J. Page , J. M. MacDonald , J. Winnike and R. RADIATION IS PRO-APOPTOTIC IN TESTIS. 3 1 D. Wolfinger . CIIT Centers for Health Research, R. Rasoulpour and K. Boekelheide. Brown 2 Research Triangle Park, NC, University of North University, Providence, RI. Carolina, Chapel Hill, NC and 3SAS Institute, Cary, NC. #2099 AKT1 SUPPRESSES RADIATION-INDUCED GERM CELL APOPTOSIS IN VIVO. T. #2094 A DATA-BASED ASSESSMENT OF Rasoulpour1, K. DiPalma2, B. Kolvek1 and M. ALTERNATIVE STRATEGIES FOR Hixon1. 1Pathology, Brown University, Providence, IDENTIFICATION OF POTENTIAL HUMAN RI and 2Biology, Providence College, Providence, 4 1 CANCER HAZARDS. N. Doerrer , A. Boobis , RI. J. Bucher2, S. Cohen3, D. Jacobson Kram5, J. MacDonald6 and D. Wolf7. 1Imperial College #2100 EFFECT OF ESTROGENIC EXOGENOUS London, London, United Kingdom, 2NIEHS CHEMICALS EXPOSURE ON CORTACTIN National Toxicology Program, Research Triangle PROTEIN EXPRESSION IN MOUSE TESTIS. Park, NC, 3University of Nebraska Medical Center, M. Yoshida1, R. Anahara1, M. Kai2, F. Ishino2 and C. Omaha, NE, 4ILSI Health and Environmental Mori1, 3. 1Department of Bioenvironmental medicine, Sciences Institute, Washington, DC, 5FDA Center Graduate School of Medicine, Chiba University, for Drug Evaluation and Research, Rockville, MD, Chiba, Japan, 2Department of Epigenetics, Tokyo 6Schering-Plough Research Institute, Kenilworth, Medical & Dental University, Tokyo, Japan and NJ and 7EPA National Health and Environmental 3Dnvironmental Health Science Project for Future Effects Research Laboratory, Research Triangle Generation, Graduate School of Medicine, Chiba Park, NC. University, Chiba, Japan. WEDNESDAY up-to-date information at www.toxicology.org 227
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2 K. M. , 3 Molecular 2 O. F. F. O. . , N. Seki , N. and A. M. and 1 Department 1 1, 2 . and T. Honma T. and 2 A. RAMESH Environmental Environmental 1 R. D. Thomas , R. D. , W. T. Jewell T. W. , Biomedical Sciences, 2 1 , T. Adachi T. , 1, 2, 5 . 3 1 Annual Meeting Annual 1, 2 th and 2 Department of Genomic 3 Meat Animal Research Meat , X. Gao 2 , H. Fukata 2 1, 2 , L. L. Needham 2 Center for Environment, Health Center for Environment, 5 , J. J. Ford J. , J. , N. Jia , N. SOT's 45 SOT's 1 1 K. Yamazaki K. A. R. Campbell Environmental Sciences Institute, Environmental , 1 1 . M. G. Miller and M. G. 1 and M. Komiyama 1 Beijing Diseases Control and Prevention and Prevention Beijing Diseases Control S. F. Darling-Reed , S. F. 2 1 National Center for Environmental Health, National Center for Environmental 1 National Health and Environmental Effects Effects National Health and Environmental 2 . 1, 2, 5 , E. L. Gray Department of Functional Genomics, 1 1 4 Y. Yanagisawa , Y. , M. Suda 1 1, 2 College of Pharmacy and PharmaceuticalCollege Sciences, Obstetrics & Gynecology, Meharry Medical Obstetrics & Gynecology, National Institute of Industrial Health, Kawasaki, Health, Kawasaki, National Institute of Industrial for Future Health Science Project Environmental Research Laboratory, U.S. EPA, Research Triangle Triangle Research EPA, U.S. Research Laboratory, NC. Park, AND DNA INDUCTION OF PC3 CELL DEATH Calafat of Bioenvironmental Medicine, Graduate School Medicine, Graduate of Bioenvironmental chiba, Japan, of Medicine, Chiba University, J. Silva J. Toxicology, UC Davis, Davis, CA and Davis, UC Davis, Toxicology, Wang Florida A&M University, Tallahassee, FL. Tallahassee, A&M University, Florida College, Nashville, TN, TN, Nashville, College, STRAND BREAKS BY BENZO[A]PYRENE- (BPDE). 10-EPOXIDE 8-DIOL-9, 7, 2 Japan, chiba, Japan and chiba, Japan. ADDUCTS OF PROTEIN IDENTIFICATION AFTER AND GENE EXPRESSION CHANGES MOLINATE. TOXICANT TESTICULAR THE A. Rodriguez 1 GA and BIOCHEMICAL ANALYSIS OF ETHYLENE ANALYSIS BIOCHEMICAL MONOETHYL ETHER INDUCED GLYCOL TESTES OF RAT. THE IN CELL DEATH 1 Japan and IN MOUSE EXPRESSION LEVELS EPIDIDYMIS. Sato C. Mori 2 Generations, Graduate School of Medicine, Chiba chiba, Japan, University, R. D. Gragg R. D. FL and Tallahassee, A&M University, Florida Meharry Medical College, Nashville, TN. Meharry Nashville, Medical College, HEALTH TOXIC OF EXTRAPOLATION WITH DOSED OUTCOMES IN RODENTS TO DI(2-ETHYLHEXYL)PHTHALATE SELECTED HUMAN POPULATIONS. IDENTIFICATION AND IDENTIFICATION AND OF NOVEL CHARACTERIZATION AND EFFECTS OF GENES UNKNOWN DIETHYLSTILBESTROL NEONATAL THESE GENES ON TREATMENT Drug Discovery Science, Graduate School of Drug Discovery kyoto, University, Pharmaceutical Sciences, Kyoto kashiwa, Sciences, Chiba University, and Field X. Yu China. Sponsor: X. Beijing, Center, A. E. Archibong A. E. L. Spearow Centers for Disease Control and Prevention, Atlanta, Centers for Disease Control and Prevention, Nwagbara Structure Facility, UC Davis, Davis, CA. Davis, UC Davis, Structure Facility, OF INTER-SPECIES COMPARISION TESTICULAR MICROSOMAL AND LIVER OF BENZO(A)PYRENE. METABOLISM Graduate School of Medicine, Chiba University, Graduate School of Medicine, Chiba University, Center, USDA, Nebraska and USDA, Center,
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. 2, 1 Molecular, Molecular, 2 Pfizer, and C. 2 3 J. Bishop , J. 1 M. Niehaus EXPOSURE Physiology and Physiology 2 G. F. Weinbauer F. G. Covance, Muenster, Muenster, Covance, . 1 G. W. Wolfe W. and G. 1 . and Y. Akgul Y. and 2 1 M. G. Miller , M. G. P. M. Foster P. 1, 2 California National Primate 1 Gene Logic, Gaithersburg, MD. Gaithersburg, Gene Logic, . 3 Environmental Toxicology, UC Toxicology, Environmental 3 , R. C. Derk St Barbara Clinic Heessen, Hamm, 1, 2 2 , G. E. Kissling 1, 2 2 ANIMALS. . 1 and A. Kamischke and 1 Pathology and Physiology Research Branch, Research and Physiology Pathology NIEHS, Research Triangle Park, NC, Park, Triangle NIEHS, Research MALE SEXUAL MATURITY AND ADVERSE ADVERSE AND MATURITY MALE SEXUAL TESTES OF MACACA EFFECTS IN Attia and Desert, M. P. Foulon, O. FASCICULARIS. Evreux, France. . CIT, R. Forster AND OF PRECISION COMPARISON AND OF PROSTATE ACCURACY THE IN TESTIS ULTRASONOGRAPHY CYNOMOLGUS MONKEY. HYPOSPERMATOGENESIS AND HYPOSPERMATOGENESIS OF KEY STAGES OF CHARACTERISATION THE TESTIS OF THE IN SPERMATOGENESIS A. Shaha. A CASE STUDY. DOG – BEAGLE Laboratories Ltd., Harrogate, United Covance Research Center, UC Davis, Davis, CA, Davis, UC Davis, Research Center, Cellular, and Integrative Physiology, UC Davis, UC Davis, Physiology, and Integrative Cellular, CA and Davis, B. Quintanilla- Solis-Heredia, E. Rojas-Garcia and B. Mexico Section, CINVESTAV, Toxicology . Vega Mexico. D.F., City, Germany and Germany Germany. Muenster, . Covance, Weinbauer F. and G. TOBACCO EFFECTS OF ENVIRONMENTAL SMOKE ON RHESUS MONKEY SPERM Hung P. FUNCTION. Niehaus D. Everett Kingdom. Sponsor: D. 1 WV and NIOSH, Morgantown, DETERMINATION OF THE DI-(2- OF DETERMINATION (DEHP) NOAEL ETHYLHEXYL)PHTHALATE IN DEVELOPMENT FOR REPRODUCTIVE OF RETENTION OF IMPORTANCE RAT: THE EXTRA F R. E. Chapin 1 Groton, CT and A. VandeVoort A. LEYDIG CELL (LC) T FORMATION, OR T FORMATION, LEYDIG CELL (LC) SIDE- LC P450 CHOLESTEROL VIVO EX ACTIVITY (P450SCC) CHAIN CLEAVAGE ALONE. WITH M TREAMENT BY EXERTED IN VIVO IN THE CONCOMITANT Murono E. P. Germany. IN ANALYSIS UROFLOW NON-INVASIVE THE CYNOMOLGUS MONKEY. OF YOUNG MALE ADULT RATS TO THE TO RATS ADULT MALE YOUNG OF AND (M) PESTICIDE METHOXYCHLOR 780 (ICI) ICI 182, ANTIESTROGEN THE IN THE DECLINES ALTER DOES NOT SERUM WEIGHT, VESICLE (SV) SEMINAL VIVO EX (T) LEVEL, TESTOSTERONE Davis, Davis, CA. Davis, Davis, INDUCES SPERM METHYL-PARATHION Pina-Guzman, M. IN MICE. B. DAMAGE DNA Pharmacology, West Virginia University School University Virginia West Pharmacology, V. Sponsor: WV. of Medicine, Morgantown, Castronova 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#2104 #2105 #2103 #2107 #2101
#2102 Program Description Description Program #2106 #2108
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) Wednesday, March 8 #2121 VALIDATION OF THE NQO1 ACTIVE SITE 1:30 PM to 4:30 PM MODEL BY DOCKING STUDIES AND Exhibit Hall MECHANISTIC STUDIES OF SELECTIVE TOXICITY OF GOOD LAVENDAMYCIN 1 2 POSTER SESSION: COMPUTATIONAL TOXICOLOGY SUBSTRATES OF NQO1. M. Hassani , W. Cai , J. Gerdes1, M. Behforouz2 and H. Beall1. 1The Chairperson(s): Rory Conolly, U.S. EPA, Research Triangle Park, NC and University of Montana, Missoula, MT and 2Ball Elizabeth Gross, CIIT, Research Triangle Park, NC. State University, Muncie, IN.
Displayed: 1:30 PM–4:30 PM #2122 ADDUCTION OF CYTOCHROME C BY BENZOQUINONE AND (GLUTATHION-S- Attended: 3:00 PM–4:30 PM YL)-1, 4-BENZOQUINONE CAUSES A LOSS OF PROTEIN FUNCTION. A. A. Fisher1, #2115 A HOLISTIC APPROACH TO HAZARD M. T. Labenski1, V. Gokhale1, S. B. Bratton2, IDENTIFICATION BASED ON STRUCTURE- T. J. Monks1 and S. S. Lau1. 1Pharmacology/ ACTIVITY RELATIONSHIPS – FROM DATA Toxicology, University of Arizona, Tucson, AZ and TO MODELS. R. A. Kemper1, J. B. Majeska1, 2Pharmacology/Toxicology, University of Texas, C. Yang2 and J. Archer2. 1Toxicology and Safety Austin, TX. Assessment, Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, CT and 2Leadscope Inc., Columbus, #2123 PROMOTION OF LIVER GST-P FOCI OH. BY A CHEMICAL MIXTURE OF HEXACHLOROBENZENE (HCB) AND #2116 DYNAMICS OF EXTRACELLULAR SIGNAL- 3, 3’, 4, 4’, 5-PENTACHLOROBIPHENYL REGULATED KINASE (ERK) ACTIVATION (PCB126): INTEGRATION OF COMPUTER IN DEVELOPING CEREBELLAR GRANULE MODELING AND BIOLOGY OF CLONAL CELLS (CGC): A SYSTEMS BIOLOGY- GROWTH. Y. LU1, M. Lohitnavy1, M. Reddy1, O. ORIENTED STUDY. Q. Zhang1, W. Mundy2 Lohitnavy1, E. Eickman1, A. Ashley1, Y. Xu2 and and R. Conolly2. 1Centers for Health Research, R. Yang1. 1Environmental & Radiological Health CIIT, Research Triangle Park, NC and 2U.S. EPA, Sciences, Colorado State University, Ft Collins, Research Triangle Park, NC. CO and 2McArdle Laboratory for Cancer Research, #2117 A THREE-DIMENSIONAL ANATOMICAL University of Wisconsin, Madison, WI. MAP OF THE MAJOR EPITHELIAL TYPES #2124 STOCHASTIC SIMULATION TO OBTAIN IN THE B6C3F1 MOUSE NASAL PASSAGES. E. A. Gross1, D. R. Joyner1, 2, A. M. Jarabek1, THE EXACT SOLUTION OF THE TWO- R. 3 and J. S. Kimbell1. 1CIIT Centers for Health STAGE CLONAL GROWTH MODEL. Conolly1, K. S. Crump2 and H. J. Clewell3. 1National Research, Research Triangle Park, NC, 2Currently, Center for Computational Toxicology, U.S. EPA, UNC, Chapel Hill, NC and 3National Center for Research Triangle Park, NC, 2Environ Health Environmental Assessment, U.S. EPA, Washington, Sciences Institute, Ruston, LA and 3Center for DC. Human Health Assessment, CIIT, Centers for Health #2118 CHEMICALLY-INDUCED SKIN IRRITATION: Research, Research Triangle Park, NC. COMPUTATIONAL MODEL OF #2125 DEVELOPMENT OF A PHARMACOKINETIC- INTRACELLULAR SIGNALING PATHWAYS DRIVEN COMPUTATIONAL FLUID THAT MEDIATE INFLAMMATORY DYNAMICS MODEL TO PREDICT NASAL RESPONSE. M. S. Breen1, Y. Zeng2, Q. Zhang3, J. N. McDougal4, P. Shi4 and R. B. Conolly1. 1NCCT, EXTRACTION OF HYDROGEN SULFIDE IN J. D. Schroeter, J. S. Kimbell, M. E. Andersen U.S. EPA, Research Triangle Park, NC, 2Purdue RATS. and D. C. Dorman. CIIT Centers for Health University, West Lafayette, IN, 3CIIT Centers for Research, Research Triangle Park, NC. Health Research, Research Triangle Park, NC and 4Wright State University, Dayton, OH. #2126 ONGOING DEVELOPMENT OF BIOTRANS: A TOOL FOR PREDICTIVE XENOBIOTIC #2119 PARTICLE DEPOSITION IN THE LUNG METABOLOMICS OF CHEMICAL CENTRAL AIRWAYS. B. Asgharian, S. Gudi and A. N. Mayeno1, R. Yang1 and B. B. A. Wong. Division of Computational Biology, MIXTURES. Reisfeld1, 2. 1Environmental & Radiological Health CIIT Centers for Health Research, Research Triangle Sciences, Colorado State University, Fort Collins, Park, NC. CO and 2Chemical & Biological Engineering, #2120 NON-SPECIFIC TOXICITY REDUCTION Colorado State University, Fort Collins, CO. BY ENCAPSULATING TOXINS IN #2127 AN EXPLORATORY PARTICOKINETIC NANOLIPOSOMES: A THEORETICAL MODEL FOR ADDRESSING THE UNIQUE MODEL. D. Dimitrov and I. A. Sidorov. NCI, NIH, Frederick, MD. Sponsor: L. Anderson. CHALLENGES OF NANOPARTICLE DOSIMETRY IN VITRO. J. G. Teeguarden, P. M. Hinderliter and J. G. Pounds. Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA. WEDNESDAY up-to-date information at www.toxicology.org 229 . . 1, 1 , 1 S. S.
. , M. M. 2 , T. T. , 1 and A. and 1 , R. 4 Metabolism, 4 and M. Hirose CTG Pharma, , P. K. Moore , P. 1 3 3 , S. Strom M. Bleavins 1 , E. Urda 1 Annual Meeting Annual , B. Kanz, B. M. F. , D. J. J. , D. Bhandari N. A. Nishikawa th , J. Atherton , J. 1 . Toxicology, Toxicology, H. M. Mehendale. , Y. Kuroiwa Y. , 1 Pharmacy, NUS, Singapore, NUS, Singapore, Pharmacy, Universtiy of. A. Boelsterli of. and Universtiy , P. del Soldato , P. , J. Hanson , J. 5 4 2 National Institute of Biomedical National Institute of Biomedical 1 2 [LIVER CANALICULAR [LIVER CANALICULAR and - SOT's 45 SOT's , S. Kulkarni University of Texas Medical Branch, Medical Texas of University 3 4 , K. Kanki . Safety Sciences, Pfizer, Ann Arbor, MI, Arbor, Ann Safety Sciences, Pfizer, 1, 2 1 , R. Kubik 3 . 4 , A. Sparatore , B. K. Philip , B. 1 Pharmacology, NUS, Singapore, Singapore, Singapore, NUS, Singapore, Pharmacology, 1 . of Milan, Milan, Italy, University PA, Pittsburgh, of Pittsburgh, University Pathology, Metabolism, Pfizer, Groton, CT and Pathology, National Institute of Health Sciences, National Institute Pathology, MRP2 TRANSPORTER-DEFICIENT] RATS RATS TRANSPORTER-DEFICIENT] MRP2 ALTERATIONS WITH IS CORRELATED IN LIPID METABOLISM. Milan, Italy, Milan, Italy, Devi Pathology, University of Texas Medical Branch, Texas of University Pathology, TX. Galveston, Tokyo, Japan and Tokyo, Ong 5 2 LA. INHIBITION OF HEPATOBILIARY METHOD A PREDICTIVE AS TRANSPORT OF FOR CLINICAL HEPATOTOXICITY Kostrubsky V. NEFAZODONE. A. Kalgutkar Mireles Mutlib 2 3 DEVELOPMENT OF PHOSPHOLIPIDOSIS DEVELOPMENT OF AND HEPG2 HEPATOCYTES IN RAT ASSAYS NBD- PROBE CELLS USING PHOSPHOLIPID PE OR NILE RED STAIN. 1 AstraZeneca, Cheshire, United Kingdom. Sponsor: Pognan F. M. Treinen-Moslen Chen and M. Y. Ramasubramanian, Pfizer, Ann Arbor, MI. Sponsor: Arbor, Ann Pfizer, M. Treinen-Moslen M. TX and Galveston, Monroe, of Louisiana at Monroe, The University TO METHYLENEDIANILINE INJURY TR LIVERS OF Innovation, Osaka, Japan. Innovation, IN EFFLUX ACID OF BILE MODULATION METHOD NOVEL HEPATOCYTES:A RAT TRANSPORTER OF FOR QUANTIFICATION C. Summers, G. Hopwood, J. INHIBITION. Assessment, Barrett, Safety K. Jones and G. Kenna. ADDUCT DIFFERENTIAL COVALENT AND OF DICLOFENAC BIODISTRIBUTION ESTER IN SULFURATED A DICLOFENAC AND SMALL INTESTINE. LIVER RAT Figueroa, J. W. Lawrence and D. L. Gerhold. Merck and D. Lawrence W. J. Figueroa, PA. Point, West Research Laboratories, TRANS-4-HYDROXY-2- OF INVOLVEMENT IN LEC PROTEINS NONENAL-MODIFIED LESIONS. HEPATIC RAT Singapore. THE IS TISSUE REPAIR INHIBITED MECHANISM OF POTENTIATION THIOACETAMIDE-INDUCED OF IN DIABETIC RATS. HEPATOTOXICITY Imazawa
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Meeting & ToxExpo & Meeting 3 1, , 1 , A. , , 2 5 and 1 , J. , J. 2 Division Division K. Mori 3
, S. K. , C. K. Wise , C. K. Physiology Physiology 1 2 1 . Division of Division 1 2 Drug Safety , J. Kanno , J. Environmental Environmental 1 1 , E. Ney 2 4 . , K. Tanphichai , K. 2 , M. Ogura Pharmaceutical 1 1 1, 2 . 1 J. Zhang , J. 2 , P. E. Blackshear , P. 2 H. Sato Biotechnology, Sangji Biotechnology, 2 S. A. Ferguson , S. 1 Preclinical Services, Charles 1 . C. Mahagita , R. Taniguchi , R. 3 2 , E. K. Lobenhofer 3 and P. Piyachaturawat and P. , D. P. Orzech P. , D. G. A. Boorman and G. 2 2 M. W. Fariss W. and M. Constella Group, Inc., Research Triangle Triangle Constella Group, Inc., Research A service unit Labs, Array Paradigm 2 1 3 4 Bioinformatics, Institute of Medicinal 1 . , A. Ono , . F. J. Cisneros J. F. 2 1 Environmental Medicine, University of Medicine, University Environmental 2 Integrated Laboratory Systems, Inc., Research , J. S. Parker , J. Cellular & Molecular Toxicology Division, National Division, Toxicology Molecular & Cellular Molecular Design, Inc. (IMMD), Tokyo, Japan and Tokyo, Molecular Design, Inc. (IMMD), Sivaraman Research Laboratory, Daiichi Pharmaceutical Co., Research Laboratory, Japan, Tokyo, Ltd., Edogawa-ku, and L. A. Poirier and L. TWENTY EIGHT DAYS OF ORAL TWENTY EIGHT DAYS ACID) (13-CIS-RETINOIC ISOTRETINOIN INDUCES EPIGENETIC TREATMENT SPRAGUE-DAWLEY ADULT CHANGES IN RATS. R. D. Irwin R. D. Triangle Park, NC. Park, Triangle Department, Mahidol University, Bangkok, Thailand Bangkok, Department, Mahidol University, 5 2 Sciences, University of Colorado Health Sciences of Colorado Health Sciences, University CO and Denver, Center, MECHANISM. and NETWORK ANALYSIS FOR TOXICITY TOXICITY FOR ANALYSIS NETWORK DISRUPTORS PREDICTION OF ENDOCRINE USING KEYMOLNET. A. Itai 2 Japan. Sponsor: Tokyo, Institute of Health Sciences, Inoue T. H. Roycroft N. Ballatori N. Toxicology Program, National Institute of National Institute Program, Toxicology Triangle Health Sciences, Research Environmental NC, Park, Rochester, Rochester, NY. Rochester, Rochester, GENE EXPRESSION CHANGES HEPATIC WITH LIPID METABOLISM ASSOCIATED THE FISCHER RAT. IN AGE WITH University, Wonju, Kangwon-do, South Korea. Kangwon-do, Wonju, University, 4-HYDROXYACETOPHENONE-INDUCED AN BY IS MEDIATED CHOLERESIS IN RATS GLUTATHIONE-DEPENDENT AND MRP2- Neurotoxicology, National Center for Toxicological Toxicological National Center for Neurotoxicology, AR and Jefferson, FDA, Research/U.S. River Laboratories, Horsham, PA, Laboratories, Horsham, PA, River of Molecular Epidemiology, National Center for National Center of Molecular Epidemiology, AR. Jefferson, FDA, Research/U.S. Toxicological E SUPPLEMENTATION VITAMIN DIETARY MITOCHONDRIA ENRICHES HEPATIC ALPHA LEVELS OF WITH PROTECTIVE Rhim T. TOCOPHEROL. Park, NC, Park, NC and Park, Triangle of Icoria, Inc., Research Takagi
45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#2129 Wednesday, March 8 March Wednesday, Attended: : Glenn Sipes, University of Arizona, Tucson, AZ and Lei Tucson, Arizona, of Chairperson(s): Glenn Sipes, University AR. Jefferson, USFDA-NCTR, Guo, Displayed: 1:30 PM to 4:30 PM Exhibit Hall LIVER II POSTER SESSION:
#2128 Program Description Description Program #2132 #2131 #2130
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2140 ENVIRONMENTAL FACTORS OUTWEIGH #2147 ALTERED BILIARY CLEARANCE OF DRUG-RESPONSE FACTORS AT EARLY THYROXINE (T4) AND T4-GLUCURONIDE TIME POINTS IN TOXICOGENOMIC (T4-G) IN MRP2-DEFICIENT RATS: EFFECTS EXPERIMENTS. D. Mulhern1, S. Yokokawa1, OF PHENOBARBITAL (PB) AND DPC-904. L. Y. Ohshima1, Y. Adachi1, A. Kohara2, T. Suzuki3, W. LeCureux1, M. Z. Dieter2, H. Wong3, B. Gemzik1, N. Miyata4, S. Ninomiya1 and T. Sudo1. 1ADME/ B. D. Car1, C. D. Klaassen2 and L. D. Lehman- TOXICOLOGY Research Institute, Daiichi Pure McKeeman1. 1Bristol Myers Squibb, Princeton, NJ, Chemicals Co., Ltd., Tokaimura, Japan, 2Division 2University of Kansas Medical Center, Kansas City, of Genetics and Mutagenesis, National Institute of KS and 3Genentech, South San Francisco, CA. Health Sciences, Tokyo, Japan, 3Division of Cellular & Gene Therapy Products, National Institute of #2148 HYPOXIA POTENTIATES Health Sciences, Tokyo, Japan and 4Division of HEPATOCELLULAR KILLING BY Organic Chemistry, National Institute of Health NEUTROPHIL MEDIATORS IN VITRO. P. J. 1, 2, 3 1, 2, 3 1, 2, 3 Sciences, Tokyo, Japan. Sponsor: T. Inoue. Shaw , J. P. Luyendyk , P. E. Ganey and R. A. Roth1, 2, 3. 1Pharmacology & Toxicology, Michigan #2141 THE USE OF RAT LIVER SLICES IN State University, East Lansing, MI, 2National COMPOUND SELECTION. A. Reising1, R. Food Safety & Toxicology Center, Michigan State Bruno1, E. Cruz1, A. Garami2, S. Mangialaio2, A. University, East Lansing, MI and 3Center for Wolf2 and K. Rose1. 1Biomarker Development, Integrative Toxicology, Michigan State University, Novartis Pharmaceuticals, East Hanover, NJ and East Lansing, MI. 2Novartis Pharma AG, Basel, Switzerland. #2149 PREDICTION OF METABOLIC CLEARANCE #2142 INTEGRATED OMIC ANALYSIS OF HEPATIC OF BISPHENOL A USING CRYOPRESERVED TUMOR PROMOTERS EFFECTS IN RAT HUMAN HEPATOCYTES. R. Kuester and G. LIVER. A. Naito1, L. Schnackenberg1, R. Holland1, Sipes. Pharmacology, The University of Arizona, L. Muskhelishvili2, D. Morris3, R. Baillie3, S. Tucson, AZ. Dial1, C. Melvin1, J. Fuscoe1, H. Fang1, W. Tong1, R. Beger1, R. Edmondson1 and Y. Dragan1. #2150 INVESTIGATION OF BIOLOGICAL 1Division of systems Toxicology, NCTR, Jefferson, MEDIATORS DERIVED FROM ACTIVATED AR, 2Toxicologic Pathology Associates, NCTR, RAT LIVER CELL MIXTURE USING Jefferson, AR and 3Lipomics Technologies, Inc., MOLECULAR APPROACHES. R. Hu, S. Taylor, West Sacramento, CA. D. Wen, S. Patterson, M. Davis, M. Hayashi, M. Damore, P. McDonagh and C. Afshari. Amgen Inc., #2143 IN SILICO EVALUATION OF Thousand Oaks, CA. HEPATOTOXICITY USING DEREK FOR WINDOWS. R. R. Note1, M. L. Patel1, C. A. Wednesday, March 8 Marchant1 and N. Greene2. 1Lhasa Limited, Leeds, 1:30 PM to 4:30 PM United Kingdom and 2Safety Sciences - Groton, Exhibit Hall Pfizer Global Research & Development, Groton, CT. POSTER SESSION: CARDIOVASCULAR SYSTEM: #2144 CHARACTERIZATION OF A THREE- CARDIOTOXICITY DIMENSIONAL HUMAN LIVER BIOREACTOR. M. A. Christie1, K. M. Young1, Chairperson(s): Richard Peterson, University of Wisconsin Madison, J. W. Ludlow1, S. O. Sherwood1, M. B. Johnston1, Madison, WI and Phil Kopf, University of New Mexico, Albuquerque, NM. 1 1 2 G. L. Kedderis , N. G. Hentz , C. M. Seagle , Displayed: 1:30 PM–4:30 PM J. H. Winnike2 and J. M. Macdonald2. 1Admet Technologies, Durham, NC and 2Biomedical Attended: 3:00 PM–4:30 PM Engineering, University of North Carolina, Chapel Hill, NC. #2151 ERBB2 PROTEIN IS INCREASED IN DOXORUBICIN CARDIAC TOXICITY. K. L. #2145 OVEREXPRESSION OF CALPASTATIN Gabrielson, N. Muratore, S. Pin, L. Wachtman and IN HEPATOCYTES PROLIFERATING IN D. Bedja. Comparative Medicine, Johns Hopkins CULTURE MAKES THEM RESILIENT TO University, Baltimore, MD. CALPAIN-MEDIATED INJURY. V. S. Bhave, S. Donthamsetty and H. M. Mehendale. Toxicology, #2152 COPPER SUPPLEMENTATION INHIBITS University of Louisiana at Monroe, Monroe, LA. AORTIC BANDING-INDUCED HEART HYPERTROPHY IN A MOUSE MODEL. #2146 NONALCOHOLIC STEATOHEPATITIS C. L. Reynolds1, Y. Jiang2, W. Rodriguez1, K. (NASH): MECHANISMS OF HEPATOTOXIC Merten2, X. Sun2 and Y. Kang3, 2, 1. 1Physiology/ SENSITIVITY. S. Donthamsetty1, V. Bhave1, Biophysics, University of Louisville, Louisville, KY, M. Mitra1, J. Latendresse2 and H. Mehendale1. 2Pharmacology/Toxicology, University of Louisville, 1university of louisiana, monroe, LA and 2NCTR, Louisville, KY and 3Medicine, University of jefferson, AR. Louisville, Louisville, KY. WEDNESDAY up-to-date information at www.toxicology.org 231
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. 2 2 . . 2 , S. 1 , and M. 1 College College 2 Safety 2 CURRENT 2+ , R. S. Grippo 1 M. Carter N. Walker and N. , D. Brott and D. 3 1 , R. E. Peterson 1 Annual Meeting Annual , M. Herberth 1 th , S. Trauth , S. , A. Xie , 1 1 Molecular and Environmental Molecular and Environmental 1 , J. Schofield, J. 1 Biological Sciences, Arkansas Arkansas Sciences, Biological School of Pharmacy, University University School of Pharmacy, . 1 2 2 . . SOT's 45 SOT's NIEHS, Research Triangle Park, NC Park, Triangle NIEHS, Research 2 2 D. S. Antkiewicz S. D. C. P. Chengelis , C. P. 2 , C. E. Brown 1 Sepracor Inc., Marlborough, MA. 2 , C. Louden WIL Research Laboratories LLC, Ashland, Ashland, WIL Research Laboratories LLC, 1 1 S. Torres S. Meng, Cook, J. D. University of Chicago, Chicago, IL. University . 3 2 safety assessment, astrazeneca pharmaceuticals, College of Pharmacy, University of South Carolina, University of Pharmacy, College TIMECOURSE ANALYSIS OF THE INTRA- OF ANALYSIS TIMECOURSE LEFT BANDING–INDUCED AORTIC RENAL H. MICE. IN HYPERTROPHY VENTRICULAR M. H. Kushida, H. Inoue, M. Sugai, Higashiyama, Toxicology Center, University of Wisconsin, Wisconsin, of University Center, Toxicology WI and Madison, MACCLESFIELD, United Kingdom and MACCLESFIELD, and B. J. Gurley J. and B. Assessment, Astrazeneca Pharmaceuticals, Assessment, DE. WILMINGTON, H. B. Jones CHANNEL OPENER ZD6169. H. B. Gould 1 . Medicinal Chemistry, . Medicinal Chemistry, Thatcher R. Kastrati and G. IL. of IL at Chicago, Chicago, University CA L-TYPE TCDD STIMULATES C SIGNALING KINASE A PROTEIN VIA VENTRICULAR IN GUINEA PIG PATHWAY Wang D. MYOCYTES. 1 Columbia, SC, and Lee OH and Department,Asano. Pharmacology Kinoshita and S. Tsukuba Research laboratories, GlaxoSmithKline, Ibaraki, Japan. IN EPITHELIAL STRUCTURES ECTOPIC OF CYNOMOLGUS MONKEY THE HEART Kaspareit, S. J. FASCICULARIS). (MACACA E. Buse and G. Habermann.Friderichs-Gromoll, Germany. Laboratories GmbH, Muenster, Covance Vogel Sponsor: F. AHR2 AND ARNT1 MEDIATE THE CARDIAC THE CARDIAC ARNT1 MEDIATE AND AHR2 IN EMBRYONIC TCDD OF TOXICITY ZEBRAFISH. AZT- TO IN UTERO CHILDREN EXPOSED 3TC. A. Grippo . Lovelace Respiratory . Lovelace Walker and V. Walker D. NM. Albuquerque, Research Institute, AND ITS CONSTITUENTS METABOLIFE AN CELLS, CARDIAC ATYPICAL INCREASE A. BY NICOTINE. EFFECT EXACERBATED ALDH2 AND GTN BIOACTIVATION TO NO. TO AND GTN BIOACTIVATION ALDH2 MYOCARDIAL DOSE-RESPONSE-BASED, INJURY ARTERIAL AND CORONARY POTASSIUM TO DUE SEPARATION of Wisconsin, Madison, WI. Madison, Wisconsin, of TRNA INDUCTION OF MITOCHONDRIAL IN HIV-NEGATIVE GENE MUTATIONS BIOMARKERS OF ISOPROTERENOL- O’Neill P. T. DAMAGE. INDUCED CARDIAC of Pharmacy, University of Arkansas for Medical of University of Pharmacy, Schlenk AR. Sponsor: D. Sciences, Little Rock, State University, State University, AR and State University, State University, Tarantino P. and W. Heideman W. and
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Meeting & ToxExpo & Meeting K. 1, 2 , I. S. 1 and . , W. W. , Covance Covance 2 3 , H. Yang , H. . H. M. 1, 2 S. G. Zhou, National and G. Kito. 2 , 1 K. C. Lund and
, S. Jamalfar 2 3 , T. Williams T. , , C. Yan , C. 2 GlaxoSmithKline, 1, 2 2 K. B. Wallace and K. B. School of Pharmacy, School of Pharmacy, 1 . 1 M. S. Mitra , M. Liu , A. Swain , 2 NCTR, Jefferson, AR. NCTR, Jefferson, 2 1, 2 Beijing Institute of Pharmacology Beijing Institute of Pharmacology , C. Scudamore 1 2 . J. R. Latendresse , J. 1 University of Louisiana at Monroe, University 1 1, 2 . University of Louisville, L. Cai. University . 1 , J. Guo , J. and J. Turton and J. 1 , C. Stamp and 1, 2 2 , M. York , M. 1 and G. Wang and G. Department of Biochemistry & Molecular Biology, Department of Biochemistry & Molecular Biology, of Minnesota Medical School, Duluth, University MN. PROTECTION ZINC PRETREATMENT DOXORUBICIN-INDUCED AGAINST THE DEPENDS ON CARDIOTOXICITY METALLOTHIONEIN. LEVELS OF CARDIAC Research, Beijing, China. Y. Kang Y. Louisville, KY. HIGHER STAT3, UPREGULATED AND ENERGY LEVELS CATALASE, RATS DIET-RESTRICTED PROTECT DOXORUBICIN-INDUCED FROM CARDIOTOXICITY. Donthamsetty Mehendale Monroe, LA and Biomedical Laboratories, Ltd (SNBL), kagoshima, Biomedical Laboratories, Ltd (SNBL), kagoshima, Japan. TRANSCRIPTASE NUCLEOSIDE REVERSE INHIBIT CAMP- (NRTI) INHIBITORS OF PHOSPHOREGULATION DEPENDANT HEART. COMPLEX I IN RAT J. Ferguson J. United Kingdom. Sponsor: H. Magotani, Torikai, Y. β3-ADRENOCEPTOR. M. Hijioka, Yonamine, H. Shigeyama, T. A. Suzuki, K. Fukuzaki, R. Nagata K. Kuwano, A STUDY INVESTIGATING SERUM SERUM INVESTIGATING A STUDY LEVELS IN ISOPROTERENOL- TROPONIN INJURY. INDUCED CARDIOMYOCYTE Brady Roman London, United Kingdom, Griffiths and Toxicology, Beijing, China and Toxicology, and THE EFFECT OF CGP12177 ON THE ON THE EFFECT OF CGP12177 SYSTEM IN NON- CARDIOVASCULAR OF AS NEW CONCEPT HUMAN PRIMATES, S. Peng Laboratories Ltd., Harrogate, North Yorkshire, Yorkshire, NorthLaboratories Ltd., Harrogate, Ware, Hertfordshire, United Kingdom and Ware, Beijing Center for Drug Safety Evaluation and Beijing Center for Drug Safety Evaluation Drug Research Laboratories, Shin Nippon Safety . Biochemistry and Molecular Biology, . Biochemistry and Molecular Biology, Wallace B. of University Graduate Program, Toxicology Minnesota Medical School, Duluth, MN. PREVENTS METALLOTHIONEIN CELL CARDIAC ANGIOTENSIN-INDUCED SUPPRESSION OF THROUGH DEATH ACTIVATION. OXIDASE NADPH OF BIOENERGETIC PHENOTYPE MITOCHONDRIAL NRTI-INDUCED Rolo, L. Peterson, A. P. CARDIOMYOPATHY. Berthiaume A. Bjork, J. J. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2169 SPECIES DIFFERENCES IN #2176 CARDIOVASCULAR SAFETY CARDIOVASCULAR EFFECTS FOLLOWING PHARMACOLOGY EVALUATIONS DURING INTRAVENOUS ADMINISTRATION OF EXERCISE STRESS IN DOGS. C. R. Hassler1, COCAINE AND METHAMPHETAMINE IN M. Coffee1, M. Ellinger1, M. Hawk1, R. Lordo1, M. TELEMETERIZED BEAGLE DOGS AND Stonerook1, T. Vinci1, B. Wood1 and R. Hamlin2. CYNOMOLGUS MONKEYS. M. P. Benson, J. A. 1Battelle, Columbus, OH and 2The Ohio State Dalton, J. R. May and P. E. Newton. MPI Research, University, Columbus, OH. Sponsor: M. Hejtmancik. Mattawan, MI. #2177 CARDIOVASCULAR SAFETY #2170 2, 3, 7, 8-TETRACHLORODIBENZO-P- PHARMACOLOGY EVALUATION IN NON- DIOXIN (TCDD) EXPOSURE DURING FETAL HUMAN PRIMATES: COMPARISON OF DEVELOPMENT PREDISPOSES MALE CONSCIOUS AND UNCONSCIOUS MODELS. OFFSPRING TO CARDIAC DYSFUNCTION M. Ouellet1, 2, S. Authier1, 2, A. Nelson1 and A. IN ADULTHOOD. A. C. Aragon1, P. G. Kopf1, B. Abedian1. 1LAB. Preclinical Research, Laval, Goens2 and M. K. Walker1. 1College of Pharmacy, QC, Canada and 2School of Veterinary Medicine, University of New Mexico, Albuquerque, NM and University of Montréal, St-Hyacinthe, QC, Canada. 2Pediatrics, University of New Mexico School of Sponsor: I. Dean. Medicine, Albuquerque, NM. #2178 KNOWLEDGE OF CARDIOVASCULAR #2171 SUB-CHRONIC, LOW LEVEL EXPOSURE RISK FACTORS IN KOSOVO: A STUDENT OF ADULT MALE MICE TO 2, 3, 7, 8- PROJECT. J. M. Donohue1, A. Cocaj2, O. Gjergji3, TETRACHLORODIBENZO-P-DIOXIN (TCDD) T. Kalefi3, M. Kashari4 and Q. Sinanaj2. 1Health and INDUCES OBESITY AND HYPERTENSION. Ecological Criteria Division, U.S. EPA, Washington, P. G. Kopf, A. K. Lund and M. K. Walker. College of DC, 2Biology, University of Pristina, Pristina, Pharmacy, University of New Mexico, Albuquerque, Kosovo, Yugoslavia, 3Medicine, University of Tirana, NM. Tirana, Albania and 4Natural Sciences, University of Tirana, Tirana, Albania. Sponsor: E. Ohanian. #2172 TRANSCRIPTIONAL RESPONSE TO 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN IN #2179 DIFFUSION AND PERCEPTION OF ZEBRAFISH LARVA HEARTS. S. A. Carney1, J. MERCURY RISK INFORMATION. D. D. Chen1, C. Burns2, 3, K. M. Xiong1, R. E. Peterson1 Petersen1, 2. 1Research & Development, U.S. EPA, and W. Heideman1. 1University of Wisconsin, Cincinnati, OH and 2Biology and Horticulture, Madison, WI, 2Massachusetts General Hospital, University of Cincinnati, Cincinnati, OH. Charlestown, MA and 3Harvard Medical School, Boston, MA. Wednesday, March 8 #2173 DIFFERENCES IN CARDIOVASCULAR 1:30 PM to 4:30 PM RESPONSE TO PM EXPOSURE BETWEEN Exhibit Hall SPONTANEOUSLY HYPERTENSIVE STROKE-PRONE (SHSP) AND WISTAR- POSTER SESSION: RISK ASSESSMENT—METALS KYOTO (WKY) RATS. A. P. Carll1, W. H. Rowan2, J. Wallenborn3, D. W. Winsett2, M. Schladweiler2, Chairperson(s): Lisa Yost, Exponent, Bellevue, WA. 3 2 L. B. Wichers , D. L. Costa , Universtiy of. P. Displayed: 1:30 PM–4:30 PM Kodavanti2 and W. P. Watkinson2. 1Student Contractor ORD/NHEERL/ETD/PTB, U.S. EPA, Research Attended: 1:30 PM–3:00 PM Triangle Park, NC, 2ORD/NHEERL/ETD/PTB, U.S. EPA, Research Triangle Park, NC and #2180 IMPLICATIONS OF CHANGES IN THE 3Environmental Sciences and Engineering, UNC ARSENIC CANCER SLOPE FACTOR FOR 1 2 School of Public Health, Chapel Hill, NC. RISK COMMUNICATION. L. Yost , J. S. Tsuji , C. G. Scrafford3, L. M. Barraj3 and P. J. Mink3. #2174 ULTRASONIC ANALYSIS, A TOOL FOR 1Exponent, Saint Paul, MN, 2Exponent, Bellevue, EARLY DETECTION OF CARDIOTOXIC WA and 3Exponent, Washington, DC. LESIONS: PRELIMINARY FINDINGS. J. Dunnick1, D. Rouse2, P. Myers2, C. Vanderklok3, #2181 DEVELOPING RECOMMENDED EXPOSURE A. Nyska3, J. Johnson3, J. Horton3, W. Lieuallen4, LEVELS FOR AIRBORNE ARSENIC. M. Seeley D. Malarkey3, R. R. Maronpot3 and K. Johnson3. and T. S. Bowers. Gradient Corporation, Cambridge, 1Toxicology Operations Branch, NIEHS/NIH/ MA. 2 DHHS, Research Triangle Park, NC, Comparative #2182 INTEGRATION OF THE AVAILABLE Medicine Branch, NIEHS/NIH/DHHS, Research GENOMIC DATA FOR INORGANIC ARSENIC 3 Triangle Park, NC, Laboratory of Experimental SPECIES TO SUPPORT THE DEVELOPMENT Pathology, NIEHS/NIH/DHHS, Research Triangle OF A NONLINEAR CANCER DOSE- 4 Park, NC and Pathology Associates International, RESPONSE MODELING APPROACH. P. R. Cary, NC. Gentry1, T. McDonald1, D. Sullivan1, J. Yager2, K. S. 1 3 1 #2175 Crump and H. J. Clewell . ENVIRON International INHALATION OF FINE PARTICLES 2 3 MODIFIES CARDIOVASCULAR FUNCTION Corp., Ruston, LA, EPRI, Palo Alto, CA and CIIT, IN AGED RATS. M. T. Kleinman, A. Hamade and Research Triangle Park, NC. D. Meacher. Community and Env. Med., University
California, Irvine, Irvine, CA. WEDNESDAY up-to-date information at www.toxicology.org 233
2 S. M. C. D. C. D. .
2 , S. S. , M. 1, 2 Exponent, M. K. 1 2 R. S. R. J. Welsh R. J. Agency for Agency 1 NHEERL, U.S. NHEERL, U.S. Oak Ridge . 3 1 1 and and . C. Carlson, 2 2 2 Exponent, Bellevue, Exponent, Bellevue, Annual Meeting Annual , N. Roney , N. 2 T. A. Lewandowski , T. 1 M. R. Garry 1 th
and W. J. Shields J. W. and 3 , F. S. Mowat , F. and H. Abadin and H. 1 2 , D. J. Williams J. , D. C. Smith 1 , J. Kulas , J. Gradient Corporation, Cambridge, B. D. Beck D. B. 2 SOT's 45 SOT's 1 . 3 J. C. Lipscomb and J. 1 NCEA, U.S. EPA, Research Triangle Triangle Research EPA, NCEA, U.S. . Center for Food Safety . Center for Food and M. Bolger NCSU, Raleigh, NC and NCSU, M. Osier 1 2 Exponent, Bellevue, WA and WA Exponent, Bellevue, J. S. Tsuji S. J. , . 1 Teck Cominco, Anchorage, AK. Anchorage, Cominco, Teck 1 3 3 . . Applied Biotechnology Applied Biotechnology . Schlager J. and J. 1 L. J. Yost , L. J. 2 Gradient Corporation, Seattle, WA and Gradient Corporation,WA Seattle, 2 A. A. Rooney A. ORD, NCEA, U.S. EPA, Cincinnati, OH. EPA, NCEA, U.S. ORD, Syracuse Research Corp, NY. Syracuse, 2 2 Environmental and Occupational Health, University and Occupational Health, University Environmental Electric Power Research Institute, Palo Alto, CA. Research Institute, Palo Electric Power HEALTH RISK ASSESSMENT FOR ASSESSMENT RISK HEALTH AREA USING WORKERS INDUSTRIAL ASSESS SOIL TO WEIGHTED STATISTICS ARSENIC EXPOSURE. AND LEAD Park, NC, Park, Williams EPA, Research Triangle Park, NC. Park, Triangle Research EPA, ACTION MODE OF TOXIC EVALUATING PLASTIC STABILIZERS: OF ORGANOTIN OF MIXTURES. RISKS ASSESSING HEALTH Selgrade WA, Seattle, Washington, of PLATINUM HYPERSENSITIVITY: A HYPERSENSITIVITY: PLATINUM THE ASSESSING FOR PROTOTYPE TO EXPOSURE RISKS FROM HEALTH WEIGHT CHEMICAL MOLECULAR LOW AMBIENT SENSITIZERS IN RESPIRATORY Hussain OH. ASSESSMENT FOR RISK APPROACHES METAL “INERT” OF NANOMATERIALS: OXIDES. Kaetzel AIR. Institute for Science and Education, Cincinnati, OH and and SUBSISTENCE FOODS CONSUMPTION ACTIVITIES AND SUBSISTENCE HARVEST IN ROAD TRANSPORT A MINING NEAR ALASKA. NORTHWEST Shock 1 and S. Leppert. Leppert Associates, Inc., Golden, Associates, and S. Leppert. Leppert CO. COMPARISON A QUANTITATIVE MODELS OF DOSE-RESPONSE AND FOR METHYLMERCURY DEVELOPMENT. NEUROBEHAVIORAL Carrington Yager W. and J. MA, 3 Branch, Human Effectiveness Directorate, Wright Directorate, Branch, Human Effectiveness AFB, Wright-Patterson Base, Air Force Patterson CA. Menlo Park, ESSENTIALITY. GA Atlanta, Substances and Disease Registry, Toxic ZINC: EVALUATION OF TOXICITY VS. TOXICITY OF EVALUATION ZINC: ASSESSMENT RISK HUMAN HEALTH THROUGH EXPOSURE OF METALS J. C. Lambert J. and Applied Nutrition, USFDA, College Park, MD. Park, College USFDA, Applied Nutrition, and THE POSSIBLE OF EVALUATION OF INTERACTION TOXICOLOGICAL FOR USE IN RISK AND MERCURY LEAD ASSESSMENT. WA and WA TOXICITY ASSESSMENT TOXICITY VITRO IN IN RAT NANOPARTICLES OF SILVER MACROPHAGES. ALVEOLAR
(Continued) Annual Annual th #2193 #2197 #2196 #2201 #2194 #2198 #2199 #2195 #2200 45 , 234 1 Meeting & ToxExpo & Meeting , . M. 2 1 , 1 and . . , T. T. , 1 1 Health 5 and L. 1 Georgia- Gradient 3 J. K. , J. 1 , D. D. D. , D. 1 J. S. and J. 1 . 4 1 . A. Schoen M. R. Garry , Y. W. Lowney W. Y. , A. G. , A. G. TERRA, Inc., M. Mumtaz L. Ogden 1 2 Luxembourg Luxembourg , Y. W. Lowney W. Y. , 2 Health Sciences 1 4 , R. Dalvi 1 and 3 Exponent, Boulder, Exponent, Boulder, 1 and R. C. James . 1 3 Exponent, Boulder, CO Exponent, Boulder, 2 . , M. A. Kelsh , M. 3 B. D. Beck D. and B. 1 Food and Chemicals Group, Food S. S. Shock 3 . OfficeAlexeeff V. and G. Pathobiology, Tuskegee Tuskegee Pathobiology, , M. Mansour 2 Health Sciences Group, Exponent, Group, Sciences Health 1 S. E. Holm J. A. Kind , J. 2 2 , B. A. Bessinger , B. 2 and 2 , L. M. Barraj 2 Biomedical Sciences, Tuskegee University, University, Tuskegee Biomedical Sciences, 1 , T. Datiri T. , 2 . Health Sciences Group, Exponent, Inc., Health Sciences Group, M. A. Marty , M. 2 1 J. E. Goodman , J. ToxLogic, LLC, Potomac, MD and LLC, Potomac, ToxLogic, 2 . , C. Halmes 2 5 Exponent, Lake Oswego, OR. Oswego, Exponent, Lake 1 3 TERRA, Inc., Tallahassee, FL and FL and Tallahassee, TERRA, Inc., Exponent, Bellevue, WA, WA, Exponent, Bellevue, Group, Exponent, Inc., Menlo Park, CA and Park, Group, Exponent, Inc., Menlo Industries (Pamol) Ltd., Tel Aviv, Israel. Aviv, Tel Ltd., Industries (Pamol) AND DIELDRIN ARSENIC EFFECT OF MIXTURES IN FEMALE RATS. Denver, FL. Denver, L. D. Peterson L. D. Washington, DC, Washington, R. J. Golden R. J. CO., CO., . OEHHA, Cal/EPA, Oakland, CA. Oakland, . OEHHA, Cal/EPA, A. M. Fan EVALUATION HUMAN HEALTH-BASED ACQ- OF CHEMICAL EXPOSURES FROM A. Cushing C. WOOD. TREATED PacificAtlanta, GA. Corporation, GUIDANCE CHILD-SPECIFIC HEALTH Office Carlisle and K. C. Dowling. J. FOR LEAD. Assessment, Health Hazard of Environmental Agency, Protection California Environmental Tuskegee, AL and Tuskegee, R. W. Freeman W. SOIL LEAD LEVELS? R. Britt 1 G. Alexeeff Sacramento, CA. Sponsor: G. and Billups 1 Eldan Graham J. F. Collins F. J. Brown, P. ARSENIC. J. Salmon Tsuji USE OF BENCHMARK DOSE METHODOLOGY ON HUMAN NONCANCER PROTECTIVE DEVELOP HEALTH TO DATA TO CRITERIA FOR CHILD EXPOSURES IS INORGANIC ARSENIC A CANCER RISK A CANCER RISK ARSENIC IS INORGANIC Chapel KBinc, DOSES? K. G. Brown. LOW AT Tsuji Hill, NC. Sponsor: J. Dale, IL, Wood Inc., of Environmental Health Hazard Assessment, Health Hazard of Environmental Agency, Protection California Environmental CA. Oakland, META-ANALYSIS OF LOW LEVEL ARSENIC LEVEL OF LOW META-ANALYSIS AND BLADDER CANCER: EXPOSURE ASSESSMENT FOR RISK IMPLICATIONS Mink J. P. UNITED STATES. THE IN Corporation, Cambridge, MA and WITH PREDICTING BLOOD LEAD LEVELS MODERATE AT OVER-PREDICTION IEUBK: DEVELOPMENT OF PUBLIC HEALTH DEVELOPMENT OF PUBLIC HEALTH 8-TCDD IN 7, 3, AND 2, FOR COPPER GOALS A. Howd R. M. Sullivan, WATER. DRINKING Exponent, Inc., Washington, DC, Washington, Exponent, Inc., ASSESSMENT OF SOLUBILITY AND ASSESSMENT OF SOLUBILITY IN MINE- OF BARITE BIOACCESSIBILITY SOILS. IMPACTED Alexander Sciences Group, Exponent, Inc., Bellevue, WA. Inc., Bellevue, Sciences Group, Exponent, University, Tuskegee, AL. Sponsor: Tuskegee, University, DMAV–INDUCED BLADDER TUMORS: TUMORS: BLADDER DMAV–INDUCED SUSCEPTIBILITY. RAT UNIQUE 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Program Description (Continued) #2202 COMPARATIVE SOLUBILITY OF #2205 4:52 OPPORUNITIES AND CHALLENGES NANOPARTICLES AND BULK OXIDES FOR THE USE OF RISK ASSESSMENT IN OF MAGNESIUM IN WATER AND LUNG EVALUATING FOOD BIOSECURITY VS. SIMULANT FLUIDS. J. A. Pickrell1, S. Castro2, G. FOOD SAFETY. A. M. Kadry1, C. Maczka2, J. Gakhar1, K. J. Klabunde3, E. Hayden1, S. Hazarika1, Kause1 and M. Catlin2. 1Risk Assessment Division, F. W. Oehme1 and L. E. Erickson2. 1Diagnostic USDA/FSIS, Washington DC, DC and 2Office of Medicine/Pathobiology, Kansas State University, Food Defense and Emergency Response, USDA/ Manhattan, KS, 2Chemical Engineering, Kansas FSIS, Washington DC, DC. State University, Manhattan, KS and 3Chemistry, Kansas State University, Manhattan, KS. #2206 5:02 FOOD SAFETY FROM AN INTERNATIONAL PERSPECTIVE. A. Tritscher. JECFA, World Health Organization, Geneva, Switzerland. Wednesday, March 8 4:30 PM to 6:00 PM #2207 5:16 IS THE FOOD SUPPLY AT RISK FOR Room 5A AN ATTACK? THE FOOD SAFETY AND INSPECTION SERVICES ACTIVITIES TO ROUNDTABLE SESSION: FOOD SAFETY AND SECURITY: PROTECT THE FOOD WE EAT. M. Catlin. REGULATORY AND INDUSTRY SAFEGUARDS Office of Food Defense and Emergency Response, FSIS/USDA, Washington DC, MD. Chairperson(s): Jay Vodela, USDA, Washington, DC and Michelle Catlin, National Academy of Sciences, Washington, DC. Wednesday, March 8 Endorsed by: 4:30 PM to 6:00 PM Food Safety SS* Room 5B Regulatory and Safety Evaluation SS Risk Assessment SS ROUNDTABLE SESSION: U.S. EPA’S 2005 CANCER GUIDELINES
Throughout human history, there have been many threats to the security Chairperson(s): Lynn Flowers, U.S. EPA, Washington, DC and Martha of nations. These threats have brought about large-scale losses of life, the Moore, USFDA-NCTR, Jefferson, AR. destruction of property, widespread illness and injury, the displacement Endorsed by: of large numbers of people, and devastating economic loss. Bioterrorism, Biological Modeling SS* Germ warfare and Chemical agents. All are names for a different type of Risk Assessment SS warfare, one in which the enemy is microscopic and deadly. Following the terrorist attacks on the World Trade Center and the Pentagon in September U.S. EPA’s recently released Guidelines for Carcinogen Risk Assessment 2001, awareness and concerns of the use of biological or chemical agents and Supplemental Guidance for Assessing Susceptibility from Early-Life on food supply have increased considerably at Federal and State Govern- Exposure make greater use of the increased scientific understanding of ment levels. Everyday, millions of Americans carry out their daily lives the biological mechanisms that can cause cancer. In assessing the cancer assuming that the food they eat is safe and wholesome. A number of risks of a chemical, the Guidelines emphasize the value of understanding Federal Agencies, including the Food Safety and Inspection Service (FSIS), the biological changes that the chemical can cause and how these changes the Animal and Plant Inspection Service (APHIS), the U.S. Food and Drug might lead to the development of cancer. The Guidelines suggest that Administration, and the U.S. Environmental Protection Agency, work with mode-of-action (MOA) data, when available and of sufficient quality, the food industry to safeguard the food supply. Traditionally, the major can be useful for understanding the potency of a chemical, its potential focus in the U.S. has been food safety that is, ensuring that any microorgan- effects at low doses, whether findings in animals are relevant to humans, isms and potentially toxic chemical residues unintentionally present in food and which populations or lifestages may be particularly susceptible. The are at a low enough concentrations to not present a public health threat. Supplemental Guidance notes that childhood may be a lifestage of greater With concerns over terrorist attacks, however, those agencies and industry susceptibility for a number of reasons, such as rapid growth and devel- have also been working to prevent intentional attacks on the food supply, opment that occurs prenatally and after birth, differences related to an and to prepare to respond in the unfortunate event that an attack occurs. immature metabolic system, and differences in diet and behavior patterns The food industry and the agencies that regulate it have taken many actions that may increase exposure. The Guidance presents age-dependent adjust- to prevent both unintentional and intentional contamination of the food ment factors for the carcinogenic potency of chemicals with a mutagenic supply. This symposium will highlight some recent efforts the agencies and MOA. Key implementation issues focus on the use of MOA data in risk industry have taken to ensure food safety and food security. assessment, lifestage issues related to carcinogenesis, and determination of #2203 4:30 FOOD SAFETY AND SECURITY: a mutagenic mode of carcinogenic action. Decisions related to the determi- REGULATORY AND INDUSTRY nation of MOA for carcinogenicity have implications for risk assessment, SAFEGUARDS. J. Vodela and H. L. Walker. risk characterization, and regulatory actions. The views expressed in this Residue Branch, USDA/FSIS, Washington DC, DC. abstract are those of the authors and do not necessarily reflect the views of the U.S. EPA or U.S. FDA. #2204 4:38 OVERVIEW OF FOOD DEFENSE. D. Acheson. Center for Food Safety and Applied Nutrition, #2208 4:30 CARCINOGENIC MODE OF ACTION AND Food and Drug Administraiton, College Park, MD. U.S. EPA’S 2005 CANCER GUIDELINES. L. 1 2 3 Sponsor: J. Vodela. Flowers , H. A. Barton , E. M. Faustman and M. M. Moore4. 1U.S. EPA, Washington, DC, 2U.S. EPA, Research Triangle Park, NC, 3University of Washington, Seattle, WA and 4NCTR, Jefferson, AR. WEDNESDAY up-to-date information at www.toxicology.org 235
Annual Meeting Annual th SOT's 45 SOT's
(Continued) Annual Annual Introduction to the Issue, David Warheit, Dupont Haskell Laboratories, Newark, DE. Recent Changes at International Agency for Research on Cancer, Conflict of Interest: Peer Review Issues Long-Range at ACC’s Research Initiative, Carol Henry, American Chemistry Council, Arlington, VA. Conflict of Interest: Peer Review Issues Science at the EPA Advisory Board, Washington, Vanessa EPA, Vu, U.S. DC. Report Review: Peer Review Issues at the National Academy of Sciences, TBA. Vincent Cogliano, Cedex, France. th Award. 8 March Wednesday, Dr. Carol Henry will discuss industry-sponsoredthe Director Vu, research. of Vanessa Dr. the Science proceduresEPA implemented for fundingAdvisory Board will discuss conflict of interest/peer review issues as they relate to the EPA Science Advisory of Sciences will be presented. Academy at the National procedures review Board. Finally, peer review/report • • • • • 8 March Wednesday, 4:45 PM to 5:15 PM Room 15B WITH STUDENTS/POST-DOCTORAL COUNCIL MEETING SOT FELLOWS All students and post-doctoral fellows are encouraged to participate in this informal meeting, which provides a dialog between two-way SOT Council and students. Sodas will be available. Wednesday, March 8 March Wednesday, 4:30 PM to 5:20 PM Room 15A LECTURE AWARDEE MERIT SPECIAL SESSION: Health, Boston, MA. of Public School Hayes, Harvard Wallace A. : Speaker Plan to attend this special lecture by the winner of the 2006 SOT Merit 4:30 PM to 6:00 PM Room 6F RECENT MEETING: HALL TOWN SPECIAL SESSION: ON REQUIREMENTS CHANGES IN PARTICIPATION GROUPS/PANELS ADVISORY GOVERNMENT Newark, Haskell Laboratories, Dupont Warheit, Chairperson: David B. DE. This special session will focus on perceptionthe issues of of conflictbias, of andinterest howmembersand thosefor peer issuesreview panels. play In outparticular, processes utilized inthefor selection of focuspeer the review panels for The willInternational selectionbe on ofthe Agency for Research on Cancer (IARC), National Academy of Sciences, American Chemistry Council—Long-Range Research Initiative Environmental U.S. Protection AdvisoryAgency—Science Board andworking the groups. Dr. Vincent Cogliano regardingwill selectiondescribe of theWorking Panelsrationale recently for implementedchanges at IARC. 45 - - - - 236 Meeting & ToxExpo & Meeting
45th Annual Meeting and ToxExpo and Meeting Annual 45th
The Oceans and Human Health Initiative, Julie Trtanj, NOAA, Washington, DC. Introduction, Banks Yolanda Anderson, North Carolina Central University, Durham, NC. Burroughs Wellcome Fund Research Resources, Jean Kramarik, Burroughs Fund, Wellcome Research Triangle Park, NC. PHRMA Foundation Opportunities, George Fuller, State Wayne University, Detroit, MI. Department of Defense Research Opportunities, Thomas E. DC. Johnson,Washington, Department of Defense, U.S. Education Committee Career Resource and Development Committee* and Development Resource Career As the availability of resources from federal agencies which traditionally support toxicology research decreases, it becomes necessary to explore a wider array of potential funding sources. This forum will provide infor • • • • • academia. Department of Defense (DOD) is a major federal sponsor of basic The U.S. and applied research. Research areas for which DOD includeprovides resources those which are congressionally-mandated, including monitoring and surveillance research, and environmental research. Funding mecha Room 6E SOURCES FOR FUNDING GRANTSMANSHIP FORUM: SUPPORT by: Sponsored Wednesday, March 8 March Wednesday, 4:30 PM to 6:00 PM gists as well as seasoned toxicologists. In addition, research starter grants provide support to individuals beginning independent research careers in agreements. nisms include grants, contracts and cooperative The Oceans and Human Health InitiativeAtmospheric of theAdministration National Oceanic (NOAA)standingand ofis the designedconnections betweento theenhanceenhance oceans capabilitiesNOAA’s andunder human throughhealth partnershipsand agencies. sector and governmental private with academia, the
mation on toxicology research resourcesfoundations, the availableBurroughs Fund Wellcome and throughthe PHRMA Foundation, two private Departmentfederal and agencies, two of the Defense U.S. and the National Oceanic and Atmospheric Administration. In addition to presentations by the panelists, information on other funding sources will be made available site. Web for the audience and posted on the CRAD The Burroughs Wellcome Fund (BWF)medical sciencesis dedicatedby supporting to researchadvancing BWF and provides othertheresources scientificto help scientistsactivities. early in as their independentcareers develop investigators and to advance fields or in need of particularsciences that are undervalued encouragement. in the basic medical The PHRMA funding provides Foundation to stimulate training and career development activities in areas of research the pharmaceuticalimportant industry. are Fellowships available for young to toxicolo the mission of Program Description Description Program
WEDNESDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY Thursday, March 9 Wednesday Evening 9:00 AM to 12:00 NOON Room 6E
Wednesday, March 8 SPECIAL SESSION: HURRICANE KATRINA: INTERFACE 6:00 PM to 7:30 PM BETWEEN RESPONSE AND RESEARCH See Events Calendar on Pages 2–6 for Room Listings Chairperson(s): Harold Zenick, U.S. EPA, Research Triangle Park, NC SPECIALTY SECTION MEETINGS/RECEPTIONS: and Henry Falk, Coordinating Center for Environmental Health and Injury BIOLOGICAL MODELING, DERMAL TOXICOLOGY, Prevention, CDC, Atlanta, GA. INHALATION, NEUROTOXICOLOGY, RISK ASSESSMENT This symposium session will set the stage and describe what conditions were encountered on the ground, initial response(s) including trade offs Wednesday, March 8 and follow up related to Hurricane Katrina. The panelists will also discuss 6:00 PM to 11:00 PM the nature of the information and research that might better help reduce See Events Calendar on Pages 2–6 for Room Listings uncertainties in decision making for future disasters. This session will end with a roundtable discussion with the audience. REGIONAL CHAPTER MEETINGS/RECEPTIONS • Welcome and Introduction, Hal Zenick, National Health and Many of the Regional Chapters meet during the SOT Annual Meeting. Environmental Effects Research Laboratory, ORD/EPA, Details for these Regional Chapter receptions and meetings are listed in the Research Triangle Park, NC and Henry Falk, Coordinating Center for Events Calendar. Environmental Health and Injury Prevention, CDC, Atlanta, GA. • Challenges and Health Needs in New Orleans, Kevin Stephens, the Thursday Morning Director for Health, NO Department of Health, New Orleans, LA. • Making Timely Risk Management Decision—Need for Appropriate Health Benchmarks, Bob Olexssy, National Risk Thursday, March 9 Management Research Laboratory, ORD/U.S. EPA, Cincinnati, OH. 8:00 AM to 8:50 AM • Clean Up: Occupational and Public Health Risks, Bruce Bernard, Room 7B Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Atlanta, GA. HISTORICAL HIGHLIGHTS SESSION: ORGANOPHOSPHATES FROM NERVE GAS TO INSECTICIDE • Mold and Related Indoor Health Risks, Tom Sinks or Howard Frumkin, National Center for Environmental Health/Agency for Chairperson(s): John Doull, University of Kansas Medical Center, Kansas Toxic Substances Disease Registry, CDC, Atlanta, GA. City, KS and Janice Chambers, Mississippi State University, Mississippi State, MS. • Assessing Damage to Coastal Ecological Resources, William Benson, Gulf Ecology Division, ORD/U.S. EPA, Gulf Breeze, FL. We will start this session with a review of the synthesis of this class of organophosphates by Gerhard Schrader in Germany and their initial Thursday, March 9 toxicity testing by Ken DuBois and his colleagues at the University of 9:00 AM to 12:00 NOON Chicago toxicity labs. John Doull will then review the development of Room 2 the OP’s as insecticides and the studies of Robert Neal, Sheldon Murphy and others at Chicago and at Edgewood Arsenal. He will conclude with SYMPOSIUM SESSION: AIR POLLUTION: VANGUARD recollections of the early meetings with FDA to establish OP tolerances. TOXICOLOGICAL APPROACHES CONSIDERING Jan Chambers will then review some of the research findings related to ATMOSPHERIC AGING chemistry, structure-activity relationships, neurotoxicity, and metabolism that comprise the substantial data base available on these compounds at Chairperson(s): Annette Rohr, EPRI, Palo Alto, CA and Ilona Jaspers, the present time. Emphasis will be on the information contributing most to University of North Carolina Chapel Hill, Chapel Hill, NC. our current understanding of the hazard posed by the OP insecticides and related to the current regulations of the OP insecticides through the Federal Endorsed by: Insecticide, Fungicide and Rodenticide Act as well as the Food Quality Inhalation SS* Protection Act. The session will conclude with comments by Gene McCon- Occupational and Public Health SS nell on testing issues (MTD etc.) and the current controversy regarding the Risk Assessment SS use of humans in testing OP’s and other pesticides. Air pollution is a complex mixture of both primary and secondary pol- #2209 8:00 OP’S FROM NERVE GAS TO INSECTICIDE. lutants. Primary pollutants are emitted directly from sources, while J. Doull1 and J. E. Chambers2. 1Pharmacology/ secondary pollutants are formed via chemical reactions occurring in the Toxicology, University of Kansas Med Center, atmosphere. Assessing the toxicity of air pollution must account for this Kansas City, KS and 2College of Veterinary heterogeneity and dynamic nature of the air pollution mixture, whereby Medicine, Mississippi State University, Misssissippi mixing of fresh (primary) and aged (secondary) materials is common. State, MS. This session focuses on novel approaches to better understand the toxi- cological effects of secondary pollutants and the effect of atmospheric aging of primary pollutants. The approaches to be discussed cover both particulate- and gas-phase pollutants and consider both the ambient and indoor environment. Presentations will describe approaches to examine the toxicity of aged coal combustion and mobile source emissions, ambi- ent particulate matter (PM) derived from long-range transport and local up-to-date information at www.toxicology.org 237 - - - -
. J. C. . J.
Iconix 1 . 2 . Safety Sciences, Annual Meeting Annual th J. Aubrecht J. , investigation of gene expression SOT's 45 SOT's J. Aubrecht and J. 1 in vivo
and
Pfizer Global Research, Groton, CT. TOXICOGENOMIC ANALYSIS OF GENE ANALYSIS TOXICOGENOMIC APPROACH EXPRESSION:AN EMERGING GENOTOXIC FOR DIFFERENTIATING Pharmaceuticals Inc., Mountain View, CA and View, Pharmaceuticals Inc., Mountain Kleinjans, S. G. van Breda, M. H. van Herwijnen, Breda, M. H. van Kleinjans, S. G. van C. Staal. Health Risk Y. and Leeuwen M. van D. Maastricht University, Toxicology, and Analysis Maastricht, Netherlands. Sponsor: R. Brennan 2 MECHANISMS. R. J. Brennan R. J. Pfizer, Inc., Groton, CT. FROM OF GENOTOXIC DISCRIMINATION CARCINOGENS BY NON-GENOTOXIC VITRO IN EXPRESSION PROFILING APPLICATION OF GENOMICS TO TO OF GENOMICS APPLICATION MECHANISMS OF EVALUATING AND CARCINOGENICITY. GENOTOXICITY
in vitro
(Continued) Annual Annual th Drug Discovery SS* Drug Discovery Regulatory and Safety Evaluation SS Regulatory and Safety Evaluation Carcinogenesis SS Carcinogenesis The potential of genomicsmolecular forlevel, investigatingimprovements in statisticalcellularplatform approaches technology,to responsesdata interpretationapplication ondatabasesand of thea of genomic availabilitydata allowing of interpretationlarge of chemically-induced expression changes in knownthe toxicants and broadapproved drugs have resultedcontext in increasing applica of the changes induced by #2217 9:10 Thursday, March 9 March Thursday, AM to 12:00 NOON 9:00 Room 8 TO OF GENOMICS APPLICATION SYMPOSIUM SESSION: AND OF GENOTOXICITY MECHANISMS EVALUATING CARCINOGENICITY Iconix Pharmaceuticals, Mountain Brennan, Richard Chairperson(s): CT. Pfizer Inc., Groton, Aubrecht, CA and Jiri View, by: Endorsed #2218 9:45 nisms of tumor progression after subchronic compound administration. #2216 9:00 tion of genomic profiling to pharmaceuticallast few years. safetyRecent researchevaluation has over suggestedthe thatof the toxicogenomicswider application may reduce the or timecarcinogenic taken topotential assess of theunderstanding developmentalgenotoxic compoundsof the by mechanismsdamagepromoting and byinduce whichneoplasia, chemicalsallowingmechanisms greaterrelevantcause to humans. attention geneticA collaborative researchto programbe orga paidnized to by the Health and Environmental on SciencesApplication Institute’s of GenomicsCommittee to Risk Assessment wasthe set utilityup to of evaluate toxicogenomic analysis chemicals.for improving Furtherrisk assessmentrecognizing of evaluation, the the FDA has issuedpotential a guidance documentof on genomicstoxicogenomicpharmaco- dataand in submissionstoxicity for industry. Thesion speakersare at in thethis forefrontses of in academiaapplying genomicand expression the profilingpharmaceutical to understandingand industry carcinogenesis.genotoxicity The presentations will developmentcover recentand applicationprogress of in comprehensivethe genomic derivationdatasets to of the genomic biomarkers investigationof genotoxicity into and mechanismscarcinogenesis, and and pathwayscarcinogens of diverse genotoxicants patterns associated with non-genotoxic rodent liver carcinogensapplication of and gene the expression data to understanding molecular mecha 45 238
3, Meeting & ToxExpo & Meeting , M. A. 1 ,
1 . . , M. 1 1 1 , I. Jaspers 1 , E. Diaz 1 B. Gonzalez- , B. Environmental Environmental 1 1 . 1 Desert Research J. McDonald J. 2 J. G. Wagner G. J. University of North University , M. Doyle 2 1 , C. Kang 1 J. Mauderly and J. Electric Power Research Electric Power 1 1 J. R. Harkema and J. . 2 2 Environmental Sciences and Environmental 1 . 1 and P. Koutrakis and P. 2 , T. Gupta T. , 1 TRANSPORTED FINE TRANSPORTED VERSUS J. Seagrave , J. 2 Center for Environmental Medicine, Center for Environmental , G. J. Keeler , G. J. 2 2 Electric Power Research Institute (EPRI), Electric Power 2 A. Rohr and I. Jaspers 1 , , P. Ruiz , P. 1 1 Department of Pediatrics, University of North University Department of Pediatrics, Toxicology, Lovelace Respiratory Research Lovelace Toxicology, East Lansing, MI and State University, Michigan MI. Arbor, Ann Michigan, University and H. E. Jeffries Institute, Palo Alto, CA and Institute, Palo Engineering, University of North Chapel Carolina, Engineering, University Health, Harvard School of Public Health, Boston, School of Public Health, Harvard . Electric Power Research Institute, Palo Palo Research Institute, A. C. Rohr. Electric Power Alto, CA. MIXTURES. K. G. Sexton 2 Hill, NC, 3 Carolina, Chapel Hill, NC. THE POLLUTION: AIR INDOOR OF CHEMICAL REACTIONS. IMPORTANCE Institute, Albuquerque, NM and Albuquerque, Institute, OF LOCAL Morishita 1 2 AGING THE EFFECT OF PHOTOCHEMICAL AIR POLLUTION OF TOXICITY THE ON 1 J. J. Godleski J. PLANT EMISSIONS. J. Lemos MA and C. Rohr Carolina - Chapel Hill, Chapel Hill, NC. ASSESSMENT OF PM TOXICOLOGICAL POWER COAL-FIRED DERIVED FROM AIR POLLUTION: VANGUARD VANGUARD AIR POLLUTION: APPROACHES TOXICOLOGICAL AGING. ATMOSPHERIC CONSIDERING Flecha Institute, Reno, NV. A MOBILE PARTICLE USING THE EFFECTS ASSESS TO CONCENTRATOR PARTICULATE MATTER. PARTICULATE Palo Alto, CA. Palo CHARACTERIZING TO APPROACHES ATMOSPHERIC OF TOXICITY THE COAL AND OF DIESEL TRANSFORMATIONS EMISSIONS. COMBUSTION Zielinska B. Asthma, and Lung Biology, Chapel Hill, NC and Asthma, and Lung Biology, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
in vivo exposures, gas-phase and particle-phase pollutants) as
#2215 11:25 #2214 10:50 #2211 9:05 sources, complex gas-phase mixturesand mixturessubjected of toindoor atmosphericpollutants. In theaging, each atmosphereapproach, the is complexityconsidered. of Thisof inhalationsession will toxicologistsappeal withto anbroad in vitroaudience intereststo (indoor to ambient well air,as to epidemiologists and risk assessors studyingof airthe health pollutanteffects mixtures. Theprovide sessioninsights is to timelyaid researchersin thatin of complex riskatmospheresthe suchassessmenttopics as combustion willemissions,and outdoormanagement PM, and indoor air, all currently subject to regulation at local to federal levels. #2210 9:00
#2213 10:15 Program Description Description Program #2212 9:40
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2219 10:20 DEVELOPMENT AND APPLICATION TO #2223 9:15 MECHANISMS OF ACETAMINOPHEN DRUG DISCOVERY OF GENE EXPRESSION HEPATOTOXICITY: RELEVANCE FOR BIOMARKERS FOR GENOTOXICANTS AND IDIOSYNCRATIC LIVER INJURY. H. Jaeschke. CARCINOGENS. R. J. Brennan. Toxicology, Liver Research Institute, University of Arizona, Iconix Pharmaceuticals Inc., Mountain View, CA. Tucson, AZ. #2220 10:55 CHARACTERISTIC EXPRESSION PROFILES #2224 9:55 INFLAMMATORY STRESS AS AN INDUCED BY CARCINOGENS IN RAT SUSCEPTIBILITY FACTOR IN DRUG LIVER. H. J. Ahr and H. Ellinger-Ziegelbauer. IDIOSYNCRASY. R. A. Roth. Pharmacology Molecular and Special Toxicology, Bayer and Toxicology, Center for Integrative Toxicology, HealthCare AG, Wuppertal, Germany. Michigan State University, East Lansing, MI. #2221 11:30 APPLYING GENE EXPRESSION PATTERNS #2225 10:35 DRUG METABOLISM AND CHEMICAL FOR NUCLEAR HORMONE RECEPTOR STRUCTURAL ALERTS. S. Nelson. University of AGONISTS TO MECHANISMS OF Washington, Seattle, WA. HEPATOCARCINOGENESIS. L. Lehman- McKeeman. Discovery Toxicology, Bristol Myers #2226 11:15 IDIOSYNCRATIC HEPATOTOXICITY: PRE- Squibb, Princeton, NJ. CLINICAL MOLECULAR PROFILING TO DETECT AFFECTED PATHWAYS AND CHARACTERIZE INDIVIDUAL RISK Thursday, March 9 FACTORS. R. G. Ulrich. Molecular Profiling, 9:00 AM to 12:00 NOON Rosetta Inpharmatics LLC, Seattle, WA. Sponsor: C. Room 6D Alden.
SYMPOSIUM SESSION: IDIOSYNCRATIC HEPATOTOXICITY: NONCLINICAL PREDICTIVE TOXICOLOGY FOR LIVER Thursday, March 9 INJURY POTENTIAL 9:00 AM to 12:00 NOON Room 5B Chairperson(s): Carl Alden, Millennium Pharmaceuticals Inc., Cambridge, MA. SYMPOSIUM SESSION: METABONOMICS: MOVING BEYOND THE PROFILE Endorsed by: Drug Discovery SS Chairperson(s): Don Robertson, Pfizer Global Research & Development, Ann Arbor, MI and Lois Lehman-McKeeman, Bristol Myers Squibb The cost to bring a new therapeutic into the market place now approaches Company, Princeton, NJ. $1 billion. The discovery toxicologist must present a clear view of the development limiting attributes prior to the commitment of the immense Endorsed by: resource requisite to generate the data required to gain market access. Drug Discovery SS* The toxicology technology now exists, if appropriately leveraged, that Molecular Biology SS can lower the attrition rate from toxicity and side effects to less than 10% versus the current benchmark figure of over 40%. (Brughera, 2002 Over the past 5 years metabonomics technology has gained tremendous DIA) Because of predictive toxicology failures, idiosyncratic drug liver visibility within the pre-clinical toxicology community. Early research injury represents the cause of over 40% of all cases of liver failure in efforts amply demonstrated the power of metabolic profiling in models of persons over 40 years in the United Ststes. Idiosyncratic injury can result toxicity and emphasized the predictive utility of the technology. However, in withdrawal from the market (e.g. tolcapone, troglitazone) or warnings metabonomics is now moving beyond the stage of emerging technology (e.g. nefazodone, trovofloxicin, strattera) with substantive compromise and entering the crucial phase of value determination. While profiles to business success. Drug induced liver injury accompanied by both and PCA plots make impressive presentations, the technology is moving ALT and bilirubin increases represents a grave threat to the patient with to applications that will address the utility of the methods for defining an estimated 10% of affected patients progressing to liver failure (Hy’s mechanisms of toxicity and providing relevant biomarkers of effect. To Law). For the forward thinking discovery toxicologist, the emerging chal- accomplish these goals, the technology is embracing multiple platforms lenge will be to work with the medicinal chemist to synthesize the right (e.g. nuclear magnetic resonance (NMR) and mass spectrometry (MS)) molecule, of necessity leading to realtively high through put in vitro test and expanding the range of evaluated molecules, including applications systems. Various strategies are used in the early stages of lead optimiza- for lipid analyses. This symposium will focus on the state of metabonom- tion by various institutions including assays for covalent adducts, assays ic science, discussing fundamental advances in technical approaches and for oxidative stress, and more recently transcriptional profiling. The applications to investigative toxicology. Specific presentations will pro- value and impact of these early stage activities remain to be confirmed. vide an overview of the technology with emphasis on mechanisms and biomarkers, the current use of the technology in real-world pre-clinical #2222 9:00 IDIOSYNCRATIC HEPATOTOXICITY: safety assessment applications, the perils and pitfalls of using mass spec- NONCLINICAL PREDICTIVE TOXICOLOGY trometry to expand the dynamic range of the technology with particular 1 FOR LIVER INJURY POTENTIAL. C. Alden , emphasis on moving the technology into the clinical setting and the role 5 2 3 P. Watson , H. Jaeschke , P. Ortiz de Montellano , of the lipid class of biomolecules in drug discovery and safety assessment. B. Roth7, J. Waring4 and D. Evans6. 1Millennium Pharmaceuticals, Cambridge, MA, 2University of Arizona, Phoenix, AZ, 3University of Calfornia, San Francisco, San Franscisco, CA, 4Abbott Laboratories, Chicago, IL, 5University of North Carolina, Chapel Hill, NC, 6Merck and Company, West Point, PA and 7Michigan State, East Lansing, MI. up-to-date information at www.toxicology.org 239 - - - , 2 . J. J. J. J. Harvard Harvard 2 NIEHS/ 1 .
3 , M. Gillman 4 . C. Jeffcoate University of University 3 Annual Meeting Annual th University of Michigan, of Michigan, University . Duke . Duke E. Levin 4 and C. Jefcoate 5 , O. MacDougald , O. 6 Duke University, Durham, NC and Durham, University, Duke SOT's 45 SOT's 5 , E. Levin 1 W. Slikker , W. data supporting a role for environmental 1 . , E. Padilla-Banks, R. Snyder and R. Snyder , E. Padilla-Banks, R. Newbold
in vivo NCTR/U.S. FDA, Jefferson, AR. Jefferson, FDA, NCTR/U.S. in utero by a combination of nutritional influences OVERVIEW OF OBESITY AND ADIPOSE AND OF OBESITY OVERVIEW MacDougald. O. TISSUE DEVELOPMENT. MI. Sponsor: J. Arbor, Ann of Michigan, University ENVIRONMENTAL TO EXPOSURE DURING DEVELOPMENT IS ESTROGENS IN WITH OBESITY LATER ASSOCIATED NIH/DHHS, Research Triangle Park, NC, Park, Triangle NIH/DHHS, Research University of Wisconsin, Madison, WI. Madison, Wisconsin, of University R. Newbold Medical School, Boston, MA, 6 heindel OF OBESITY: PROGRAMMING PERINATAL R. Simmons. Pediatrics, OF NUTRITION. ROLE Medical School, of Pennsylvania University heindel Sponsor: J. Philadelphia, PA. LIFE. NC. NICOTINIC OBESITY INDUCED BY FETAL OVER-STIMULATION. Heindel . NIEHS/NIH, Research Triangle Park, Park, Triangle . NIEHS/NIH, Research Jefferson W. University, Durham, NC. University, OF TCDD DISRUPTION MECHANISMS OF CELL DIFFERENTIATION. FAT OBESITY: DEVELOPMENTAL ORIGINS DEVELOPMENTAL OBESITY: INFLUENCES. AND ENVIRONMENAL Wisconsin, Madison, WI, Madison, Wisconsin, Ann Arbor, MI, Arbor, Ann and
in vitro via the PPPAR gamma 1 pathway. Overall these data indicate the (Continued) Annual Annual th Regulatory and Safety Evaluation SS Regulatory and Safety Evaluation Immunotoxicology SS* Immunotoxicology A brief review of latest regulatory expectations and approaches to immu #2233 9:05 #2235 10:15 Thursday, March 9 March Thursday, #2234 9:40 #2236 10:50 12:00 NOON AM to 9:00 Room 5A BY EVALUATION IMMUNOTOXICITY SESSION: WORKSHOP TESTS IMMUNE FUNCTION King of Prussia, PA Danuta Herzyk, GlaxoSmithKline, Chairperson(s): Sciences Institute, ILSI Health and Environmental Holsapple, and Michael DC. Washington, by: Endorsed #2237 11:25 notoxicity testing will highlight the challenges and existing issues in the lism, it is clear that fat cell precursors and adipocytes themselves contain estrogen receptors both in animalsis antilopogenic. and However humans.there is In increasingthe dataadult that estrogenduring develop ment the opposite is true: estrogens result includingin increased environmentaladipose tissue which estrogensresults in increased obesityin life.later In vitro, in a clonal cell line of fibroblasts adipocytes,that differentiates bisphenolinto A or 4 nonlyl activity, phenol,stimulate chemicalsthe differentiation with of these estrogeniccells into adipocytes.there Thus are estrogens in controlling adipocytes. On to the be reduceother the hand,numbers TCDD of adipocytesappears in vito It acts using a similar cell line. possibility that part of the intractivenessfact that of it is initiatedobesity may stem from the and exposure to environmental tion chemicals.must start Thisby monitoringsuggests and thatcontrolling preven the uterine environment. #2232 9:00 45 - - - 240 .
Meeting & ToxExpo & Meeting and
and S. M. 2 L. D. Lehman- , L. D. 1 G. H. Cantor H. , G. , I. D. Wilson , I. D. 2 . B. D. Car D. B. D. Robertson D. Drug Metabolism, AstraZeneca, AstraZeneca, Drug Metabolism, 3 B. D. Car D. , B. 2 Metabonomics Evaluation Group, PfizerMetabonomics Evaluation 1 . 4 Discovery Toxicology, Bristol-Myers Squibb, Bristol-Myers Toxicology, Discovery can have profound effects on lifelong health 2 in utero nutriton. A large body of evidence has
Lipomics Technologies, West Sacremento, CA. West Technologies, Lipomics
Macclesfield, Cheshire, United Kingdom and Macclesfield, Cheshire, Princeton, NJ, Princeton, NJ, Watkins . Discovery Toxicology, Toxicology, . Discovery Lehman-McKeeman L. D. Princeton, NJ. Squibb, Bristol-Myers IN PRE-CLINICAL METABONOMICS WE? D. ARE WHERE SAFETY EVALUATION: D. Robertson Sponsor: D. . World Wide Safety Assessment, Pfizer Safety Wide World Robertson. MI. Arbor, Ann Global Research and Development, DATA: MASSES OF “GENERATING LC-MS”. OF AGE THE IN METABONOMICS Robertson Cheshire, United Kingdom. Sponsor: D. METABONOMICS: MOVING BEYOND BEYOND MOVING METABONOMICS: THE PROFILE. MI, 4 AND MECHANISMS METABONOMICS, AND DISCOVERY BIOMARKERS IN DRUG DEVELOPMENT. METABOLIC PROFILING OF LIPIDS: A OF LIPIDS: PROFILING METABOLIC EFFICACY TRANSLATING FOR PLATFORM FROM AND SAFETY KNOWLEDGE Watkins. S. M. THE CLINIC. TO DISCOVERY CA. Sacramento, West Technologies, Lipomics I. D. Wilson. DMPK, AstraZeneca, Macclesfield, DMPK, Wilson. I. D. McKeeman Global Research and Development, Ann Arbor, Arbor, Ann Global Research and Development, 45th Annual Meeting and ToxExpo and Meeting Annual 45th in utero
exposure to environmental chemicals at environmentally
in utero Reproductive and Developmental Toxicology SS* Toxicology and Developmental Reproductive Neurotoxicology SS Neurotoxicology Obesity is a growing concern worldwide. The prevalence risen dramatically of obesity in developed hascountries theover pastdecades. 2-3 has It reached epidemic proportions in the United States of adultswith moreand than 14% of 20% adolescents defined mainlyconsideredas causedbeto overeating by clinicallyphysicalandactivity lackof obese.Obesity is on a background of genetic predisposition. While the etiology of isobesity unclear it is clear that it is notoriously difficult to treat, thus preven #2229 10:00 9:00 AM to 12:00 NOON 9:00 Room 7B ORIGINS DEVELOPMENTAL OBESITY: SYMPOSIUM SESSION: INFLUENCES AND ENVIRONMENAL NC and Park, Triangle Heindel, NIEHS, Research Jerrold Chairperson(s): AR. Jefferson, USFDA-NCTR, Slikker, William by: Endorsed #2230 10:40 #2228 9:20 #2227 9:00 #2231 11:20 ogy in the etiology of obesity. While many hormones and growth factors control hormonal regulation adipose of tissue differentiation and metabo demonstrated that either low birth weight or highresult inbirth increased weight obesity canlater inboth life. There is now increasing thatevidence relevant concentrations can also result in obesity later in life.smoking In humansduring pregnancy is associated withlife. increasedIn animalobesity studieslater inexposure to nicotineenvironmental results in postnatalestrogens weight gain.or This prenatalsuggests a role for toxicol tion is critical. In this regard a new paradigm for prevention has emerged in recent years that evolved in fromearly thelife ideaand that environmental (e.g. the fetal basisfactors of adult disease). Initialnutrition work firstin focusedthis on area related to Program Description Description Program Thursday, March 9 March Thursday,
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY immunotoxicology testing of compounds. Current regulatory documents mammalian mechanisms of action. In this model, the relevant exposure emphasize the need for assessment of unintended immunosuppression in mammals is compared to a predicted plasma concentration (PC) in in development of pharmaceuticals and industrial chemicals and recom- fish or tadpoles, resulting in a plasma exposure ratio (PER = mamma- mend an immune function study, such as the T-cell dependent antibody lian/aquatic). Functional equivalence ratio (FER) between the therapeutic response (TDAR), be conducted for this purpose. Multiple test systems target in aquatic and mammalian species can be factored and a bioequiva- have been applied in TDAR evaluation, and there is uncertainty whether lence index calculated (BEI = PER/FER). A BEI < 1 would indicate that the various study designs and assays are validated and/or acceptable for use chronic ecotoxicity testing in fish and/or tadpoles is likely to be needed, in the regulatory studies. A comparative review of existing data is needed with endpoints linked to the mammalian MOA being considered. Inter- to improve communication between immunotoxicologists and to increase national experts will compare effects of specific APIs in mammalian and understanding of the impact of immunotoxicity evaluation on safety of aquatic species in relation to the model. The Workshop will be of interest novel compounds. to academic and industrial toxicologists, ecotoxicologists, regulators and #2238 9:00 IMMUNOTOXICITY EVALUATION BY ethicists. IMMUNE FUNCTION TESTS. D. J. Herzyk. #2243 9:00 PHARMACEUTICALS IN THE Safety Assessment, GlaxoSmithKline, King of ENVIRONMENT: LEVERAGING Prussia, PA. MAMMALIAN DATA FOR IN DETERMINING HUMAN PHARMACEUTICAL RESPONSES #2239 9:10 PRIMARY IMMUNE RESPONSE TO SHEEP IN AQUATIC VERTEBRATES. D. B. Huggett2, RED BLOOD CELLS (SRBC) AS THE S. F. Owen6, G. Ankley3, B. Brooks4, C. Foran5 and CONVENTIONAL TDAR TEST. G. Ladics. L. B. Kinter1. 1Safety Assessment, AstraZeneca Haskel Laboratory, E.I. Dupont Co., Newark, DE. Pharmaceuticals, Wilmington, DE, 2Global R&D, 3 #2240 9:50 COMPARISON OF PRIMARY IMMUNE Pfizer, Groton, CT, Mid-Continent Ecology 4 RESPONSES TO SRBC AND KLH IN Division, U.S. EPA, Duluth, MN, Environmental 5 RODENTS. K. White. Medical College of Virginia, Studies, Baylor University, Waco, TX, Biology, Richmond, VA. West Virginia University, Morgantown, WV and 6Institute for the Environment, Brunel University, #2241 10:30 TDAR TESTS: META-ANALYSIS OF Uxbridge, Middlesex, United Kingdom. RESULTS GENERATED ACROSS MULTIPLE LABORATORIES. P. Bugelski. Centocor, Johnson #2244 9:10 CONCEPTUAL FRAMEWORK AND MODEL and Johnson, Radnor, PA. Sponsor: M. Holsapple. RELATING MAMMALIAN DATA FOR AQUATIC ASSESSMENTS. D. B. Huggett2. #2242 11:10 IMMUNOTOXICITY TESTING IN NON- 1Safety Assessment, AstraZeneca Pharmaceuticals, RODENT SPECIES. H. Haggerty. Bristol-Myers Wilmington, DE and 2Pfizer, Croten, CT. Squibb, Syracuse, NY. #2245 9:50 CARDIAC AND GROWTH PERFORMANCE OF JUVENILE RAINBOW TROUT Thursday, March 9 (ONCORHYNCHUS MYKISS) EXPOSED TO 9:00 AM to 12:00 NOON PROPRANOLOL: COMPARING AQUATIC Room 7A AND MAMMALIAN DATA USING THE PROPOSED MODEL. S. Owen2, D. Huggett3, WORKSHOP SESSION: PHARMACEUTICALS IN THE T. Hutchinson4, J. Ericson3, M. Hetheridge4 and ENVIRONMENT: LEVERAGING MAMMALIAN DATA IN J. Sumpter2. 1AstraZeneca Pharmaceuticals, DETERMINING HUMAN PHARMACEUTICAL RESPONSES IN Wilmington, DE, 2Brunel University, Uxbridge, AQUATIC VERTEBRATES United Kingdom, 3Pfizer, Groton, CT and 4AstraZeneca, Brixham, United Kingdom. Chairperson(s): Lewis Kinter, AstraZeneca Pharmaceuticals LP, Wilmington, DE and Duane Huggett, Pfizer Global Research and #2246 10:25 DEVELOPMENT OF INTERSEX IN Development, Groton, CT. JAPANESE MEDAKA EXPOSED TO ETHINYLESTRADIOL (BIRTH CONTROL Endorsed by: PILL). C. D. Metcalf and G. C. Balch. Trent Biological Modeling SS University, Peterborough, ON, Canada. Sponsor: L. Regulatory and Safety Evaluation SS Kinter. Residues of active pharmaceutical ingredients (APIs) have been detected in #2247 11:00 SELECTIVE SEROTONIN REUPTAKE surface waters at concentrations ranging from 0.01 to 0.1 ug/l. Some APIs, INHIBITORS IN THE ENVIRONMENT: such as synthetic and natural estrogens, have been speculated to cause AQUATIC OCCURRENCE, FATE AND detrimental effects to aquatic species at very low exposure concentrations EFFECTS. B. W. Brooks and J. K. Stanley. (0.001 to 0.01 ug/l). These observations suggest more intensive ecological Department of Environmental Studies, Baylor testing is appropriate for some APIs, but determining which pharmaceu- University, Waco, TX. ticals require more intensive evaluation is difficult. APIs are extensively studied for physical-chemical, pharmacological and toxicological proper- #2248 11:30 ENVIRONMENTAL NSAIDS: OCCURRENCE ties and effects (ED50, IC50, NOAEL, LOAEL, etc) are linked to plasma AND SUB-ACUTE EFFECTS IN NON-TARGET exposure (Cmax or AUC). Therapeutic and secondary targets (i.e. receptor ANIMALS. C. M. Foran. Department of Biology, or enzyme) are usually well defined and comparative genomics suggests West Virginia University, Morgantown, WV. that these targets are evolutionarily conserved across species, especially Sponsor: L. Kinter. in fish. A model is proposed utilizing current knowledge of mammalian exposures and effects and bio-concentration principles, to assist in deter- mining need to conduct chronic ecotoxicity testing in fish or amphibians, assist in dose-setting, and to investigate specific endpoints associated with up-to-date information at www.toxicology.org 241 ,
2 I.
, M. 2 2 and and . 1 K. Zheng, University of of University , N. Honarvar , N. 2 1 , M. J. Alcocer , M. J. 1 C. Griftiths Productsaftey/ , M. Cumberbatch 1 Annual Meeting Annual 1 . Syngenta CTL, . 1 th and 2 H. Rothe . GlaxoSmithKline, King . GlaxoSmithKline, King . . I. Kimber R. J. Dearman R. J. SOT's 45 SOT's Syngenta CTL, Macclesfield, Syngenta CTL, Macclesfield, I. Kimber L. Schneider 1 , Syngenta CTL, Macclesfield, . and 2 2 1 and C. Goebel 1 . , L. Copeland, M. Selgrade Chung, L. Copeland, Y. I. Kimber F. Sponsor: F. RCC-CCR, Rossdorf, Germany. Manchester University, Manchester, United Manchester, Manchester University, Toxicology, Wella AG, Darmstadt, and Germany AG, Wella Toxicology, of Prussia, PA. OF FUNGAL POTENCY RELATIVE ALLERGIC IN INDUCING EXTRACTS ASTHMA-LIKE RESPONSES IN BALB/C Dearman R. J. INFLAMMATORY AND IMMUNOLOGICAL INFLAMMATORY A MOUSE MODEL EXPOSED EVENTS IN DIISOCYANATE. TOLUENE TO R. J. Dearman R. J. Almond, M. Cumberbatch, R. Gerberick 2 Keohavong Sponsor: P. C. J. Betts, K. Ratcliffe, R. Currie, Betts, K. Ratcliffe, CELLS (LNC). C. J. Dearman R. J. ALLERGENS. 1 Kingdom and CHESHIRE, United Kingdom. CYTOKINE DIFFERENTIAL CUTANEOUS THE SKIN RESPONSES INDUCED BY 4- SENSITIZING CHEMICALS 2, AND 2, (DNCB) DINITROCHLOROBENZENE (DNTB). 4-DINITROTHIOCYANOBENZENE Syngenta CTL, Macclesfield, Kimber. Immunology, United Kingdom. OF APPLICATION TOPICAL REPEATED AND PTD DOES NOT PPD THE HAIR DYES TH2 DEPENDENT ALLERGIC AN INDUCE WITH ELEVATED IMMUNE RESPONSE VIVO IGE LEVELS IN PLANT LIPIDS. and and CHESHIRE, United Kingdom United Kingdom. Nottingham, Nottingham, MODEL RAT A NOVEL DEVELOPMENT OF RESPIRATORY OF FOR EVALUATION OF POTENTIAL HYPERSENSITIVITY A. Genell, C. C. Maier, DRUGS. INHALATION Herzyk J. and D. Hillegas MICE. IGE RESPONSES TO THE MAJOR BRAZIL THE MAJOR BRAZIL TO IGE RESPONSES OF IMPACT ALLERGEN BER E 1 : NUT Research EPA, U.S. . NHEERL/ETD/ITB, Ward D. NC. Park, Triangle MESSAGE OF CYTOKINE A COMPARISON OBTAINED PROFILES AND PROTEIN TO DERMAL EXPOSURE FOLLOWING Daniels, M. J. E. H. Boykin, DIISOCYANATES. U.S. . ITB/ETD, and M. K. Selgrade Andrews L. D. NC. Park, Triangle Research EPA, OF MURINE TRANSCRIPT PROFILING NODE LYMPH ALLERGEN-ACTIVATED K. Kouadio and M. Ariizumi. Environmental Ariizumi. Environmental and M. K. Kouadio of Medicine, Medicine, Faculty and Preventive Japan. Okinawa, of the Ryukyus, University H. Scheffler Macclesfield, United Kingdom. OF ACTIVATION DIFFERENTIAL (LC) BY CONTACT CELLS LANGERHANS’ CHEMICAL AND RESPIRATORY
(Continued) Annual Annual th #2257 #2263 #2261 #2262 #2256 #2255 #2258 #2259 #2260 45 242
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3 . , I.
2 Bayer Bayer D. D. 2 L. Burns .
2
, S. Webber , S. 1 . L. M. Syngenta 1 , P. Kennel , P. . 2 1 . L. Ahern , L. 1 E. G. Brooks and E. G. 2 Worldwide Safety Sciences, Pfizer Worldwide 1 . 1 , W. Evering W. , 2 R. J. Dearman and R. J. 2 , C. Collaco 1 Stephanie Webber Consulting, San Diego, Consulting, San Diego, Webber Stephanie 3 , C. Herouet-Guicheney 1 , C. Lee 1 Pediatrics, UTMB, Galveston, TX. Galveston, UTMB, Pediatrics, 2 M. Zorbas
Experimental Pathology, UTMB, Galveston, TX Galveston, UTMB, Experimental Pathology, Pharmacokinetics, Dynamics, and Metabolism, Global Research & Development, San Diego, CA, Diego, San Global Research & Development, D. Rouquie D. Knippels, S. J. Koppelman, P. Nieuwenhuizen, H. H. Nieuwenhuizen, P. Koppelman, Knippels, S. J. of Life, TNO Quality A. H. Penninks. de Jongh and T. Hamano and N. Tsutsui. Toxicology Laboratory, Laboratory, Toxicology Tsutsui. Hamano and N. T. Mitsubishi Pharma Corporation, Kisarazu, Chiba, Hochman V. Feron Zeist, Netherlands. Sponsor: V. Kimber 1 and CA. SCREENING FOR DRUG-INDUCED VITRO IN USING REACTION ANAPHYLACTOID HMC-1. HUMAN LEUKEMIC MAST CELLS, Sugimoto Japan. Sponsor: J. Naas and 2 Pfizer San Diego, & Development, Global Research CA and LACK OF RESPIRATORY AND CONTACT AND CONTACT OF RESPIRATORY LACK THE OF SENSITIZING POTENTIAL DRUG ANTIVIRAL INTRANASAL WEIGHT- A RUPINTRIVIR: CANDIDATE OF-THE-EVIDENCE EVALUATION. CropScience, Sophia Antipolis, France. CropScience, Sophia INTER-LABORATORY COMPARISONS COMPARISONS INTER-LABORATORY ASSESSMENT OF PROTEIN THE OF IN MICE. ALLERGENIC POTENTIAL COMPARISON OF SUBCUTANEOUS AND OF SUBCUTANEOUS COMPARISON OF EXPOSURE FOR ORAL ROUTES ALLERGENICITY OF FOOD EVALUATING and M. K. Selgrade C. C. Bowman EXTRACTS. EXAMINATION OF TOXICOLOGICAL TOXICOLOGICAL OF EXAMINATION ON AIR POLLUTANTS EFFECTS OF ACTIVATION. (RBL-2H3) BASOPHIL Research EPA/NHEERL, U.S. Immunotoxicology, NC. Park, Triangle THERAPEUTIC AND THE SENSITIZING AND REDUCED/ OF NATIVE POTENTIAL ALBUMIN BRAZIL NUT 2S ALKYLATED AN ORAL BROWN. (BER E 1) IN CTL, Macclesfield, United Kingdom and 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#2250 9:00 AM–10:30 AM AM–10:30 Attended: 9:00 #2249 9:00 AM to 12:00 NOON 9:00 Room 6A AND MECHANISMS HYPERSENSITIVITY: POSTER SESSION: METHODS Fragrance Institute for Api, Research Anne Marie Chairperson(s): Research EPA, U.S. Ward, NJ and Marsha Lake, Woodcliff Materials Inc., NC. Park, Triangle NOON AM–12:00 9:00 Displayed: Thursday, March 9 March Thursday, Program Description Description Program #2254 #2252 #2251 #2253
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2264 EXPOSURE OF MICE TO PHTHALATE #2273 REGULATORY EXPERIENCE WTH THE IS WITHOUT ADJUVANT EFFECT ON LOCAL LYMPH NODE ASSAY (LLNA) IN THE ANTIBODY RESPONSES. L. Beresford, L. UNITED KINGDOM. A. Cockshott1, P. Evans1, C. Bailey, C. J. Betts, R. J. Dearman and I. Kimber. A. Ryan2, F. Gerberick2, C. J. Betts3, R. J. Dearman3, Syngenta CTL, Macclesfield, CHESHIRE, United I. Kimber3 and D. A. Basketter4. 1HSE, Bootle, Kingdom. United Kingdom, 2Procter & Gamble, Cincinnati, OH, 3Syngenta CTL, Macclesfield, CHESHIRE, #2265 ALLERGEN-INDUCED CYTOKINE AND United Kingdom and 4Unilever SEAC, Bedford, CHEMOKINE RESPONSES IN A549 HUMAN United Kingdom. ALVEOLAR TYPE II-LIKE BRONCHIAL EPITHELIAL CELL CULTURES. J. Y. Edwards1, #2274 FINAL VALIDATION OF A FLOW M. Baccam1, K. Sarlo1, L. Fridthjof2, N. Berg2, N. K. CYTOMETRY-BASED LOCAL LYMPH Soni2 and E. Roggen2. 1Miami Valley Laboratories, NODE ASSAY WITH ENHANCED Procter & Gamble Company, Cincinnati, OH and IMMUNOPHENOTYPIC ENDPOINTS. 2Novozymes, Bagsvaerd, Denmark. M. K. Reeder, D. R. Cerven, A. C. Gilotti and G. L. DeGeorge. MB Research Laboratories, #2266 CIS-BIXIN IS RESPONSIBLE FOR THE Spinnerstown, PA. POSITIVE CONTACT SENSITIZATION INDUCED BY ANNATTO IN FEMALE BALB/ #2275 DERMAL SENSITIZATION QUANTITATIVE C MICE. W. Auttachoat1, D. R. Germolec2, K. L. RISK ASSESSMENT (QRA) FOR White1 and T. L. Guo1. 1Phar/Toxicology, Virginia FRAGRANCE INGREDIENTS. A. Api1, D. Commonwealth University, Richmond, VA and A. Basketter2, P. A. Cadby3, M. Cano4, G. Ellis5, 2NIEHS, Research Triangle Park, NC. G. Gerberick6, P. Griem7, P. M. McNamee8, C. A. Ryan6 and R. J. Safford2. 1Research Institute #2267 INHIBITION OF DELAYED CONTACT for Fragrance Materials, Inc., Woodcliff Lake, HYPERSENSITIVITY IN THE MOUSE – A NJ, 2Safety and Environmental Assurance Center, VALIDATION STUDY. S. Rowton. Covance Unilever, Sharnbrook, United Kingdom, 3Firmenich, Laboratories Ltd., Harrogate, United Kingdom. Inc., Geneva, Switzerland, 4LVMH, Orleans, Sponsor: D. Everett. France, 5Givaudan France Fragrances, Argenteuil, 6 #2268 GENE EXPRESSION AND CYTOKINES France, Procter & Gamble Company, Cincinnati, 7 8 PROFILES FOR THE DIFFERENTIATION OF OH, Clariant, Sulzbach, Germany and Procter & CHEMICAL SENSITIZERS AND IRRITANTS. Gamble Company, Egham, United Kingdom. 1 1 1 1 1 H. Ku , S. Jeong , H. Kang , H. Pyo , J. Cho , S. #2276 USE OF SAR TO PREDICT SENSITISING 1 2 1 Son and D. Ryu . Toxicology Division, NVRQS, POTENTIAL OF PHARMACEUTICAL 2 Anyang, Kyunggi, South Korea and College of PROCESS MATERIALS. C. W. Seaman1, M. Veterinary Medicine, Seoul National University, J. Olson3 and F. J. Guerriero2. 1Occupational Seoul, South Korea. Toxicology, GlaxoSmithKline, Ware, United 2 #2269 CHEMICAL SUBSTANCES WHICH EACH Kingdom, GlaxoSmithKline, Research Triangle 3 COUNTRY EVALUATES TO PRODUCE Park, NC and GlaxoSmithKline, King of Prussia, SENSITIZATION. T. Murakami1, T. Oyama1, PA. 1 2, 1 1 1 T. Isse , R. Narai , T. Kinaga , M. Ogawa , T. #2277 EXTRAPOLATING LOCAL LYMPH NODE 1 1 1 Yamaguchi and T. Kawamoto . Department of ASSAY EC3 VALUES TO ESTIMATE Environmental Health, University of Occupational RELATIVE SENSITIZING POTENCY. C. and Environmental Health, Kitakyushu, Japan and Ryan1, J. G. Chaney1, P. S. Kern2, R. J. Dearman3, I. 2 Mazda Motor Corporation, Hiroshima, Aki, Japan. Kimber3, D. A. Basketter4 and F. Gerberick1. 1Procter 2 #2270 ALLERGENS IN THE WORKPLACE: & Gamble Company, Cincinnati, OH, Procter & 3 J&J TIER APPROACH FOR OF Gamble Eurocor, Brussels, Belgium, Syngenta PHARMACEUTICAL ACTIVES. R. DeLuca. Central Toxicology Laboratory, Macclesfield, United 4 WW Health & Safety, J&J, Springhouse, PA. Kingdom and Unilever SEAC, Bedford, United Kingdom. #2271 INVESTIGATION OF THE RELATIONSHIP BETWEEN INDUCTION AND ELICITATION #2278 TEMPORAL STABILITY AND VEHICLE THRESHOLDS FOR CONTACT ALLERGY. J. EFFECTS ON A-HEXYLCINNAMALDEHYDE Lalko and A. Api. Research Institute for Fragrance RESPONSES AS A POSITIVE CONTROL IN Materials, Inc., Woodcliff Lake, NJ. A FLOW CYTOMETRY-BASED LLNA. G. L. DeGeorge, M. K. Reeder, C. A. Kirk and D. R. #2272 MOUSE POPLITEAL LYMPH NODE Cerven. MB Research Laboratories, Spinnerstown, ASSAY FOR ASSESSMENT OF ALLERGIC PA. POTENTIALS OF LOW-MOLECULAR COMPOUNDS. T. Aida, R. Kawai, I. Igarashi, K. #2279 PREDICTING AND CLASSIFICATION OF Kumagai, M. Ajioka, S. Hakamata, M. Teranishi, ALLERGIC POTENTIAL USING AN IN T. Kimura, S. Manabe and T. Furukawa. Medicinal VITRO SKIN SENSITIZATION TEST; HUMAN Safety Research Laboratories, Sankyo Co., Ltd., CELL LINE ACTIVATION TEST (H-CLAT). H. 1 2 1 2 Fukuroi-shi, Shizuoka, Japan. Sakaguchi , T. Ashikaga , N. Kosaka , S. Sono , H. Itagaki2 and H. Suzuki1. 1Kao Corporation, Tochigi, Japan and 2Shiseido Co., Ltd., Kanagawa, Japan. up-to-date information at www.toxicology.org 243 . .
M. T. T. M. and 2 and K. and 1 J. , J. , M. 1 C. M. 2
. Institute of H. Choudhury 2 NCCT, U.S. U.S. NCCT, OPPTS, U.S. OPPTS, U.S. 1 2 . , S. K. Hore 3 2 , M. Taylor , M. and 4 T. B. Moore B. , T. A. KANTHASAMY National Poisons National Poisons 6 Griffith University, Griffith University, Annual Meeting Annual 4 , A. B. Lowit A. B. , 1 th NHEERL, U.S. EPA, EPA, NHEERL, U.S. GlobalTox, Guelph, ON, Guelph, ON, GlobalTox, N. M. Foronda M. N. 3 1 Surgery and Radiology, Surgery and Radiology, and C. Lewis . 2 2 Ministry of Health, 5 , N. Smith , N. , A. Sachan , 3 1 A. L. Rubin V. Moser and V. , 3 J. C. Lipscomb J. SOT's 45 SOT's OTHER SENSITIVE VERSUS OTHER N. R. Reed N. Toxicology Excellence of Risk Toxicology 3 Public Health Directorate, Ministry Health Directorate, Public infoscientific.com, Carmichael, CA. Pharmacology and Toxicology, GB Toxicology, and Pharmacology 1 2 1 . . 5 J. H. Ross and J. 2 1 , S. Padilla , M. Dourson 2 2 . Pesticide Regulation, Cal/EPA, Cal/EPA, Regulation, Reed. Pesticide and N. T. P. Kellner P. , T. DOSE-RESPONSE MODELING FOR THE FOR DOSE-RESPONSE MODELING RISK DUE ASSESSMENT OF CUMULATIVE CARBAMATE N-METHYL TO EXPOSURE TO Technology, Agriculture and of University GB Pant India. Sponsor: UA, Pantnagar, Pant University of Agriculture and Technology, Technology, Agriculture and of University Pant India and UA, Pantnagar, Reaves F. Pfeifer. Department of Pesticide Regulation, Cal/ Regulation, Department of Pesticide Pfeifer. F. Sacramento, CA. EPA, IN RISK CHOLINESTERASE DATA CHOLINESTERASE II. ASSESSMENT: Goldberg L. Lim Sacramento, CA. Canada and A. K. Das Cincinnati, OH. IN CHOLINESTERASE DATA DEFINING I. ASSESSMENT: RISK SIGNIFICANCE. TOXICOLOGICAL INHIBITION ENDPOINTS. Sacramento, CA. RISK IN CHOLINESTERASE DATA AND INTRASPECIES III. ASSESSMENT: FACTORS. INTERSPECIES UNCERTAINTY R. W. Setzer W. PESTICIDES. R. Assessment, Cincinnati, OH, Lewis Research Triangle Park, NC. Park, Triangle Research FOR 1080 ANALYSIS A BENCHMARK DOSE DATA. DICHOTOMOUS Zealand and New Wellington, EPA, Washington, DC and Washington, EPA, Cal/EPA, Regulation, Department of Pesticide EPA, Research Triangle Park, NC, Park, Triangle Research EPA, W. Temple W. Zealand. Dunedin, New Center, A CHEMICAL SPECIFIC OF CALCULATION FOR LINDANE. ADJUSTMENT FACTOR Fowles Queensland, Australia, Queensland, DATA BIS(2-CHLOROETHOXY)METHANE: RISK FOR HUMAN HEALTH EVALUATION ASSESSMENT. Assessment, National Center for Environmental Office of Research and Development, EPA, U.S. Environmental Science and Research Ltd., Porirua, Science and Research Ltd., Porirua, Environmental Zealand, New of Health, Wellington, New Zealand, Zealand, New Wellington, of Health, CLINICAL AND RADIOLOGICAL CLINICAL THIRAM INDUCED APPRAISAL OF IN BROILER OSTEOCHONDROSIS Vijay V. CHICKEN.
(Continued) Annual Annual th #2285 #2291 #2290 #2292 #2286 #2287 #2289 #2288 45 244 Meeting & ToxExpo & Meeting , 5 , , 1 1 . 1 POLA , 7 2 Office LION 2 5 , D. , D. , J. Sato , J. 1 4 Shiseido
1 . M. Suzuki 8 Nippon 6 . , S. Padilla 1 A. Lowit and H. Itagaki 2 . Kao Corporation, 2 , M. Mizuno Dermatology, Tohoku Tohoku Dermatology, 3 2 Office of Pesticide Office of Pesticide 1 . and Y. Ohno Y. and 2 7 , S. Aiba , S. 1 , E. Reaves 2 . Kanebo Cosmetic Inc., Odawara, Kanebo Cosmetic Inc., Odawara, 3 , K. Okamoto 2 National Institute of Health Science, National Institute of Health , M. Yoshida , M. , S. Hagino 8 6 1 and D. Hunter and D. 2 KOSE Corporation, Tokyo, Japan, Japan, Tokyo, Corporation, KOSE , R. W. Setzer W. , R. 4 1
Safety & Analytical Reseach Center, shiseido Co., Center, Reseach Analytical Safety & of Research and Development, U.S. EPA, Research EPA, U.S. of Research and Development, NC. Park, Triangle V. Moser V. PRELIMINARY CUMULATIVE RISK CUMULATIVE PRELIMINARY THE N-METHYL ASSESSMENT OF PESTICIDES. CARBAMATE Miller DC and Washington, EPA, U.S. Programs, 1 and Japan Yokohama, Ltd., Japan. M. Miyazawa, Y. Ito, N. Kosaka, H. Kosaka, Ito, N. Y. EXPOSURE. M. Miyazawa, Sakaguchi and H. Suzuki. Kao Corporation, Haga- Avalos Gun, Japan. Sponsor: J. SENSITIZATION. VITRO FOR IN M. Hirota ANALYSIS OF ANTIGEN-CAPTURE OF ANALYSIS BINDING OF CONTACT THE PROCESS: AND CELLULAR TO ALLERGEN THE IN PROTEINS EXTRACELLULAR Ito, M. Y. THP-1 CELLS. ON ACTIVATION H. Sakaguchi Kosaka, N. Yoshida, Y. Miyazawa, Japan. Tochigi, and H. Suzuki. Kao Corporation, Avalos Sponsor: J. THP-1 CELL ON ACTS TNF-ALPHA AUTOCRINE AN BY MATURATION ALLERGEN MECHANISM FOLLOWING Tochigi, Japan, Tochigi, Japan, Japan and RESULTS OF A JAPANESE RING STUDY RING STUDY A JAPANESE OF RESULTS ACTIVATION A HUMAN CELL LINE OF FOR PREDICTING SKIN TEST (H-CLAT) Ashikaga T. POTENTIAL. SENSITIZATION H. Sakaguchi EVALUATION OF CHANGES OF CELL EVALUATION A NEW BIOMARKER AS THIOLS SURFACE CHEMICAL INDUSTORIES, INC., Yokohama, Yokohama, INC., CHEMICAL INDUSTORIES, Tokyo, Japan. Sponsor: H. Itagaki Tokyo, CORPORATION, Odawara, Japan, Japan, Odawara, CORPORATION, Co., Ltd., Yokohama, Japan, Yokohama, Co., Ltd., Menard Cosmetic Co., Ltd., Nagoya, Japan, Nagoya, Menard Cosmetic Co., Ltd., T. Yamada T. University Graduate School of Medicine, Sendai, Graduate School of Medicine, University 45th Annual Meeting and ToxExpo and Meeting Annual 45th
10:30 AM–12:00 NOON Attended: 10:30 #2284 Room 6A ASSESSMENT II RISK POSTER SESSION: Oakland, CA and Glenn Leach, Cal/EPA, Zeise, Lauren Chairperson(s): MD. Ground, Proving Aberdeen Army, US AM–12:00 NOON 9:00 Displayed: Thursday, March 9 March Thursday, AM to 12:00 NOON 9:00 #2281 #2282 #2280
#2283 Program Description Description Program
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2293 RISK ASSESSMENT OF TEN PESTICIDES IN #2301 IDENTIFICATION OF RISK-RELEVANT CYPRUS. Y. M. Ioannou1, N. Ioannou1, C. Pitta1, INTERNAL DOSE METRICS N. Seraphides1, V. Vassiliou1, A. K. Kouppari2, S. FOR USE IN ROUTE-TO-ROUTE C. Michaelidou3, P. Ziegler3 and N. Papasavva2. EXTRAPOLATION: EXAMPLES WITH 1, 1, 1Agricultural Research Institute, Ministry of 2-TRICHLOROETHANE. L. M. Sweeney1, M. Agriculture, Natural Resources and Environment, L. Gargas1 and P. Voytek2. 1The Sapphire Group, Nicosia, Cyprus, 2Department of Agriculture, Dayton, OH and 2Risk Science, Inc., Millwood, VA. Ministry of Agriculture, Natural Resources and Environment, Nicosia, Cyprus and 3State General #2302 WEIGHT OF EVIDENCE FOR Laboratory, Ministry of Health, Nicosia, Cyprus. THE NEUROTOXICITY OF PERCHLOROETHYLENE. S. Barone, R. #2294 EVALUATING DATA FOR DETERMINING McGaughy and C. S. Scott. NCEA-W, U.S. EPA, AN ORAL REFERENCE DOSE (RFD) AND Washington, DC. REFERENCE CONCENTRATION (RFC) FOR BROMOBENZENE. C. Smallwood1 and D. #2303 ACUTE EFFECTS OF HEXANAL VAPOR 3 Wohlers2. 1U.S. EPA, ORD, NCEA, Cincinnati, OH IN VOLUNTEERS. Universtiy of. Svedberg , 1 1 2 and 2Syracuse Research Corporation, Syracuse, NY. G. Johanson , L. Ernstgard , A. Iregren and 1 1 Sponsor: H. Choudhury. B. Sjogren . Work Environment Toxicology, Karolinska Institute, Stockholm, Sweden, 2National #2295 DEVELOPMENT OF A STRUCTURE- Institute for Working Life, Stockholm, Sweden and SEARCHABLE DATABASE FOR PESTICIDE 3Department of Occupational and Environmental METABOLITES AND ENVIRONMENTAL Medicine, Sundsvall Hospital, Sundsvall, Sweden. DEGRADATES. A. Protzel1, G. Dannan1, R. Kolanczyk3, Mekenyan4, S. Abel1, P. Schmieder3 and #2304 SURVIVAL FACTOR CALPASTATIN, J. Jones2. 1U.S. EPA/OPP, Washington DC, DC, 2U.S. PROTECTS SUBCHRONIC CHLOROFORM EPA/ORD/NERL, Athens, GA, 3U.S. EPA/ORD/ PRIMED MICE AGAINST LETHAL DOSE 1 1 NHEERL, Duluth, MN and 4Bourgas University, OF CHLOROFORM. B. K. Philip , P. S. Palkar , 2 3 4 Bourgas, Bulgaria. S. S. Anand , J. R. Latendresse , M. Mumtaz and H. M. Mehendale1. 1Toxicology, ULM, Monroe, #2296 EVALUATING THE HUMAN RELEVANCE LA, 2University of Georgia, Athens, GA, 3NCTR, OF ALDRIN/DIELDRIN-INDUCED MOUSE Jefferson, AR and 4ATSDR, Chamblee, GA. LIVER TUMORS: AN APPLICATION OF THE Universtiy of.S. EPA’S REVISED GUIDELINES #2305 AMBIENT CONCENTRATIONS OF BENZENE FOR CARCINOGEN RISK ASSESSMENT ARE BELOW THOSE ASSOCIATED WITH AND MODE OF ACTION FRAMEWORK. SIGNIFICANT CANCER RISK. L. A. Beyer, C. J. E. Kester1, R. Gentry2, A. M. Shipp2 and T. B. M. Long, B. D. Beck and T. M. Slayton. Gradient McDonald2. 1NewFields, Wentzville, MO and Corp., Cambridge, MA. 2 ENVIRON, Ruston, LA. #2306 NEW EPIDEMIOLOGICAL DATA SUPPORT #2297 AN UPDATED REVIEW OF THE REFERENCE THE DERIVATION OF A CHRONIC- DOSE (RFD) FOR CHLORPYRIFOS. Q. J. DURATION INHALATION MINIMAL RISK Zhao, B. Gadagbui and M. L. Dourson. Toxicology LEVEL (MRL) FOR BENZENE BASED ON Excellence for Risk Assessment (TERA), BENCHMARK DOSE (BMD) ANALYSIS. D. 1 1 2 1 Cincinnati, OH. W. Wohlers , J. Stickney and S. Wilbur . Syracuse Research Corporation, North Syracuse, NY and #2298 ATSDR’S INTERMEDIATE MINIMAL RISK 2ATSDR, Atlanta, GA. LEVEL FOR HEPTACHLOR. L. Ingerman1, Z. Rosemond2, M. Williams2 and G. Todd2. #2307 EVALUATION OF THYROID ADENOMAS 1Environmental Science Center, Syracuse Research IN MICE FOLLOWING EXPOSURE TO Corp, Syracuse, NY and 2Division of Toxicology TERTIARY-BUTYL ALCOHOL AND THEIR and Environmental Medicine, ATSDR, Atlanta, GA. RELEVANCE TO HUMANS USING THE U.S. Sponsor: M. Mumtaz. EPA’S 2005 GUIDELINES FOR CARCINOGENIC RISK ASSESSMENT. A. M. Shipp, T. McDonald #2299 MIXING RATIO INFLUENCES HALOACETIC and C. Van Landingham. ENVIRON International ACID (HAA) MIXTURE TOXICITY. J. Corp., Ruston, LA. Simmons1, E. D. Wagner2 and M. J. Plewa2. 1NHEERL/ORD, U.S. EPA, Research Triangle Park, #2308 DEVELOPMENT OF A METHANOL PBPK NC and 2University of Illinois, Urbana, IL. MODEL AND DERIVATION OF AN HEC BASED ON DEVELOPMENTAL EFFECTS #2300 A POSTULATED MODE OF ACTION FOR IN MICE. T. S. Poet1, J. T. Teeguarden1, P. M. CARBON TETRACHLORIDE LIVER Hinderliter1 and J. S. Gift2. 1Center for Biological TOXICITY. M. K. Manibusan1, J. M. Donohue2 Monitoring and Modeling, Pacific Northwest Nat, and M. Odin3. 1National Center for Environmental Richland, WA and 2NCEA, U.S. EPA, Research Assessment Environmental Protection Agency, Triangle Park, NC. Washington, DC, 2Office of Science and Technology Environmental Protection Agency, Washington, DC and 3Syracuse Research Corporation, Syracuse, NY. up-to-date information at www.toxicology.org 245 CPS 1 . 1
E. 2 Battelle, , G. IN , G. 2 1 1 and J. and J. . 3
A. Doi , 1 and T. Roth T. and 2 Annual Meeting Annual
th , M. Hejtmancik J. F. Harriman F. J. 2 , T. A. McDonald T. , 2 J. Aldridge J. National Toxicology Program, Program, Toxicology National , W. Schlosser and J. Schlosser and J. W. A. M. Kadry, 1
SOT's 45 SOT's . , H. Kauffmann 1 1 Biotechnics, Inc., Hillsborough, SSQS, Sanofi-Aventis Deutschland SSQS, Sanofi-Aventis 2 2 WIL Research Laboratories, LLC, 1 . , C. A. Colleton , C. 3 2 . , R. H. Bruner Arysta LifeScience North America, San Arysta LifeScience North 1 3 , K. Johnson, B. Tornesi, Tornesi, Stott, K. Johnson, B. T. W. . R. Jung
National Institute of Environmental Health Health National Institute of Environmental NC and Park, Triangle Sciences, Research and K. Kleinert. Dow Chemical Company, Chemical Company, and K. Kleinert.Carney Dow MI. Midland, ABSORPTION TOXICITY, ORAL SUBACUTE OF FLUOROTELOMER- AND BIOSTABILITY IN (FBAPS) POLYMERS ACRYLIC BASED RATS. VITRO Taunus, Clariant GmbH, Sulzbach am Toxicology, and Germany COMPARATIVE ORAL AND DERMAL ORAL COMPARATIVE -BUTYL OF TERT TOXICITY IN FISCHER 344 RATS HYDROPEROXIDE AND B6C3F1 MICE. and R. Chhabra H. Kinzell NC and VEHICLE EFFECTS ON MURINE LOCAL VEHICLE EFFECTS ON E. Wang-Fan, W. ASSAY. NODE LYMPH Ltd., RCC Toxicology, Deparade and L. G. Ullmann. K. Sachsse Itingen, Switzerland. Sponsor: ASSESSING HUMAN EXPOSURE TO TO EXPOSURE ASSESSING HUMAN USING IN BACON NITROSAMINES ASSESSMENT RISK PROBABILISTIC TECHNIQUES. USDA/FSIS, Division, Assessement Kause. Risk DC. Washington, G. Sponsor: G. GmbH, Hattersheim, Germany. Troschau B. Marit B. CA. Francisco, OF TOXICITY DOSE REPEATED AND (DIPA) DIISOPROPANOLAMINE AND ITS EFFECT UPON CHOLINE PHOSPHOLIPID (PL) METABOLISM Columbus, OH. EFFECTS AND CHRONIC SUBCHRONIC THYROID OF METHYL IODIDE ON IN MICE. PATHOLOGY Ashland, OH, Ashland, D. Ritchie D.
(Continued) Annual Annual th #2319 #2324 9:00 AM–10:30 AM AM–10:30 Attended: 9:00 #2321 9:00 AM to 12:00 NOON 9:00 Room 6A SAFETY EVALUATION— POSTER SESSION: NON-PHARMACEUTICAL and Derek VA Vienna, Inc., Saryu Goel, Covance Chairperson(s): CA. Sacramento, Gammon, CA EPA, AM–12:00 NOON 9:00 Displayed: #2320 9 March Thursday, #2323 #2322 45 246
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, 3 R. , W. W. ,
2 Center B. R. B. 1 R.
. 1 W. and W. 2 Department R. B. , R. B. C. Y. Chan Y. C. 3 , R. Hosea 1 2 , J. Cohen , J. 2 and G. 3 IACC, London, IACC, 1 NHEERL Human . 2 3 Y. Tan , Y. H. J. Clewell J. H. 1 , D. Whalan, D. E. J. V. A. Benignus , V. 1 BR Stern and Associates, BR Stern and , A. M. Fan and , D. Crane , D. 1 1 1 3 . 2 . Douglas Craig, DOE , G. Blumenthal ICF Consulting, Inc., Fairfax, ICF Consulting, Inc., Fairfax, 2 2 K. H. Liao
ToxSolutions, Flemington, NJ Flemington, ToxSolutions, 2 D. Gardner and D. 2 P. J. Bushnell J. P. C. D. Carrington. Department of and C. D. , M. Vasquez , M. OEHHA, Cal/EPA, Sacramento, CA, OEHHA, Cal/EPA, NHEERL Neurotoxicology, U.S. EPA, EPA, U.S. NHEERL Neurotoxicology, 3 1 1 D. K. Craig D. . M. E. Andersen E. M. . 3 , R. K. Brodberg 1 and J. Welham and J. , 1 2 2 R. Davis , J. Longstreth , J. , 1 Inhalation Toxicology Associates, Savannah, Associates, Savannah, Toxicology Inhalation 1 3 OEHHA, Cal/EPA, Oakland, CA and Oakland, OEHHA, Cal/EPA, National Center for Computational Toxicology, U.S. U.S. Toxicology, National Center for Computational VA. ASSESSMENT FOR HUMAN HAZARD GAME FROM IN UPLAND PERCHLORATE R. CALIFORNIA. J. RIVERSIDE COUNTY, Sanborn . Consultox Ltd., Damariscotta, ME. . Consultox Parent Consulting in Health Sciences and Risk Assessment, Assessment, Consulting in Health Sciences and Risk and VA Annandale, Research Triangle Park, NC and Park, Triangle Research Ford DeVoney, C. M. Thompson, P. D. White and J. J. J. White and J. D. Thompson, P. C. M. DeVoney, DC. Washington, EPA, U.S. NCEA, Vandenberg. OF RISK CHARACTERIZATION WATER. IN DRINKING PERCHLORATE United Kingdom, and GA. THE CASE FOR CAUSATION. - VIOXX . Veritox, Inc., Redmond, WA. Inc., Redmond, Veritox, . Kelman J. and B. IN SEAFOOD CHEMICAL CONTAMINANTS AND BENEFITS. OF RISKS – INTEGRATION Blondina 2 Sacramento, CA. FROM RISK OF HEPATOTOXICITY ACID. CONSUMPTION OF USNIC Stern Mendez 2 NC. Park, Triangle Research EPA, ACTION CANCER MODE OF PROPOSED ON EPA FOR FORMALDEHYDE BASED CANCER GUIDELINES. M. Bolger P. COMPARING BEHAVIORAL DOSE-EFFECT BEHAVIORAL COMPARING AND LABORATORY HUMANS FOR CURVES TO EXPOSED ACUTELY ANIMALS TOLUENE. contractor, Ponce Inlet, FL. Ponce contractor, DEVELOPMENT OF INHALATION THE THRESHOLDS OF CONCERN FOR ADDITIVES. TOBACCO OF EVALUATION Health and Human Services, USFDA, College Park, Park, College Health and Human Services, USFDA, MD. EMERGENCY EXPOSURE TEMPORARY METHODOLOGY LIMIT-DERIVATION UPDATE. A. Mekebri Conolly for Assessment, CIIT Centers for Human Health NC and Park, Triangle Health Research, Research of Fish and Game, California Resources Agency, Agency, and Game, California of Fish Resources K. Boyes Studies, U.S. EPA, Research Triangle Park, NC. Park, Triangle Research EPA, Studies, U.S. CHAIN MONTE USE OF MARKOV ESTIMATE TO ANALYSIS CARLO AND THE PHARMACOKINETIC PARAMETERS PHARMOCODYNAMIC A MODE-OF-ACTION FOR REQUIRED ASSESSMENT FOR CANCER RISK BASED CHLOROFORM. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#2313 #2312 #2318 #2315 #2314 #2311 #2309 #2317
#2316 Program Description Description Program #2310
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2325 COMPARATIVE RESPONSES OF RATS AND #2333 PRINCIPLES FOR CHARACTERIZING THE MICE EXPOSED TO LINEAR/BRANCHED, POTENTIAL HUMAN HEALTH EFFECTS LINEAR, OR BRANCHED AMMONIUM FROM EXPOSURE TO NANOMATERIALS: PERFLUOROOCTANOATE (APFO). S. E. ELEMENTS OF A SCREENING STRATEGY. Loveless1, C. Finlay1, N. E. Everds1, S. R. Frame1, J. Fitzpatrick1, G. Oberdorster2 and S. Olin1. 1Risk P. J. Gillies2, J. C. O’Connor1 and G. L. Kennedy1. Science Institute, ILSI Research Foundation, 1DuPont Haskell Laboratory, Newark, DE and Washington, DC and 2Environmental Medicine, 2DuPont Nutrition and Health, Newark, DE. University of Rochester, Rochester, NY. #2326 ACUTE AND SUBCHRONIC INHALATION #2334 TOXICITY EVALUATION OF TOXICITY OF TRIETHYLENE GYLCOL NANOPARTICLES IN MICE. A. You1, J. Kim2, BIS(2-ETHYLHEXOATE). M. P. DeLorme, N. J. Kim1, K. Park1, M. Jeong1, J. Choi1, G. Ryu1 and E. Everds, G. P. Sykes and L. A. Belcher. DuPont M. Cho2. 1Department of Crop Life Safety, NIAST, Haskell Laboratory, Newark, DE. RDA, Suwon, South Korea and 2Department of Veterinary Medicine, Seoul National University, #2327 NINETY-DAY ORAL GAVAGE Seoul, South Korea. TOXICITY STUDY OF PERFLUOROBUTANESULFONATE (PFBS) IN #2335 SAFETY ASSESSMENT OF 7- RATS. P. Lieder and J. Butenhoff. 3M Company, St. HYDROXYMATAIRESINOL (HMR) LIGNAN. Paul, MN. A. Roberts1, B. S. Lynch1, A. P. Wolterbeek2, H. Korte3, M. Unkila3 and D. H. Waalkens-Berendsen2. #2328 90-DAY ORAL GAVAGE AND 1CANTOX Health Sciences Intl., Mississauga, ON, REPRODUCTIVE/DEVELOPMENTAL Canada, 2TNO Nutrition and Food Research, Zeist, SCREENING TOXICITY STUDY OF TRIM Netherlands and 3Hormos Nutraceutical Oy Ltd., ETHYLPENTAPHENYLTRISILOXANE IN Turku, Finland. SPRAGUE-DAWLEY RATS. J. Domoradzki, L. Meeker, J. Crissman, J. Knochel, J. McMahon, S. #2336 MAMMALIAN TOXICOLOGY STUDIES OF Crofoot and K. Plotzke. Health and Enviromental SURFACTANTS PRESENT IN ROUNDUP® Sciences, Dow Corning Corporation, Midland, MI. BRANDED HERBICIDES. W. F. Heydens, D. R. Farmer and T. A. Kaempfe. Monsanto Company, St. #2329 ETHYL SILICATE: REPEAT DOSE TOXICITY Louis, MO. STUDY WITH SCREENING REPRODUCTIVE AND DEVELOPMENTAL ENDPOINTS IN #2337 TOXICOGENOMIC STUDY OF TRIAZOLE THE RAT. W. H. Koch1 and O. Foulon2. 1Epona FUNGICIDES AND PERFLUOROALKYL Associates, LLC, Willington, CT and 2CIT, Evreux, ACIDS. W. Hu1, D. Dix2, C. Lau2, R. Kavlock2, E. France. Ayanoglu1 and R. J. Brennan1. 1Toxicology, Iconix Pharmaceuticals Inc., Mountain View, CA and #2330 ORAL REPRODUCTIVE/DEVELOPMENTAL 2Office of Research and Development, U.S. EPA, TOXICITY SCREEN IN RATS WITH Research Triangle Park, NC. AMMONIUM PERSULFATE. M. L. Weiner1, E. V. Weaver2, J. R. Leininger2 and K. L. Li3. 1Toxicology, #2338 TOXICOLOGICAL EVALUATION OF FMC Corporation, Princeton, NJ, 2Covance SPEARMINT OIL ADDED TO TOBACCO: IN Laboratories, Inc., Vienna, VA and 3Formerly with VITRO AND IN VIVO TESTS. M. Misra1, R. D. FMC Corporation, Princeton, NJ. Leverette1, J. T. Hamm1 and N. Rajendran2. 1Lorillard Tobacco Company, Greensboro, NC and 2IIT #2331 OUTCOMES OF A PATHOLOGY PEER Research Institute, Chicago, IL. REVIEW AND PATHOLOGY WORKING GROUP REVIEW OF TUNICA VAGINALIS #2339 ACUTE HEMODYNAMIC AND HEMOLYTIC MESOTHELIOMAS IN FISCHER 344 RATS IN EFFECTS OF INTRAVENOUSLY A TWO-YEAR DRINKING WATER CHRONIC ADMINISTERED ETHYLENE GLYCOL IN TOXICITY-ONCOGENICITY STUDY OF THE PIG. R. Brown1, D. Wray-Cahen1, A. Lucas1, ACRYLAMIDE. H. Wall1, K. A. Johnson2, D. A. Steen1, H. Baskar2, J. Dux3 and M. Stratmeyer1. M. Creasy3, C. Gopinath4, R. A. Miller1 and E. E. 1FDA/CDRH, Silver Spring, MD, 2University McConnell5. 1Experimental Pathology Laboratories, of Maryland, College Park, MD and 3Marquette Inc., Research Triangle Park, NC, 2Dow Chemical University, Milwaukee, WI. Sponsor: P. Goering. Company, Midland, MI, 3Huntingdon Life Sciences Inc., East Millstone, NJ, 4none, Cambridgeshire, #2340 HUMAN CHEMOSENSORY AND United Kingdom and 5Toxicology Path, Inc., PHYSIOLOGICAL RESPONSES OF 1 Raleigh, NC. CHLOROPICRIN VAPOR. W. S. Cain , A. A. Jalowayski1, R. Schmidt1, J. Jeon1, T. C. Bruff1 and J. #2332 DERMAL EXPOSURE TO TITANIUM H. Butala2. 1Chemosensory Perception Laboratory, DIOXIDE NANOPARTICLES AND Otolaryngology, UC San Diego, La Jolla, CA and NANOFIBERS IN RABBITS. G. Larsen2, 2Toxicology Consultants, Inc., Gibsonia, PA. D. Gray1, B. Astroff1, D. Vu2 and M. Skotak3. 1Midwest Research Institute, Kansas City, MO, 2LNKChemsolutions, Lincoln, NE and 3University of Nebraska, Lincoln, NE. up-to-date information at www.toxicology.org 247 , 1
C. 3 , 2 and D. D. and IN 2 and . 2 Army Army 2 , J. Yoon , J. , R. 4
, N. , N. 1, 2 2 Cholinesterase Department , L. Lefkowitz Cell Biology Cell Biology 3 3 1 4 , S. Davis S. , 2 Glass Science and 2 M. Nambiar Pharmacology and Pharmacology , S. K. Sundaram Annual Meeting Annual 2 Center for Health R. C. Lantz 1 1 , th . 3 1 , B. L. Leinweber , B. 1 , R. Gordon 1 , A. Brooks A. , 2 , A. D’Ambrosio , 2 T. Weber T. Cell Biology and Biochemistry Cell Biology 1 . SOT's 45 SOT's 5 , M. R. Riley 2 K. Pinkerton Division of Biochemistry, Department of Biochemistry, Division L. K. Rogers 1 Pediatrics, Columbus Children’s Research Columbus Children’s Pediatrics, . , C. Clark , B. Capacio B. , 1 3 1 2 and . 2 1 Chemical and Environmental Engineering, Engineering, Chemical and Environmental 5
PH) ASSAY, AND MICROELLMAN AND MICROELLMAN ASSAY, ∆PH) Biological Research and Develoment, Lawrence Lawrence Research and Develoment, Biological Group, Battelle, Richland, WA, WA, Group, Battelle, Richland, and the Environment, UC Davis, Davis, CA and Davis, UC Davis, and the Environment, Balhorn V. Smith V. Livermore National Laboratory, Livermore, CA. Livermore, National Laboratory, Livermore B. R. Johnson B. 2 and ( Kirschten Goodman Medical Research Institute of Chemical Defense, MD and Ground, Aberdeen Proving SAMPLES. TOWARD NON-INVASIVE REAL-TIME NON-INVASIVE TOWARD MONITORING SITU SPECTROSCOPIC OF MACROPHAGE-NANOPARTICLE INTERACTIONS. and K. I. Ogden J. R. Haigh J. METHOD. and Anatomy, University of Arizona, Tucson, AZ Tucson, Arizona, of University Anatomy, and Center for Health Army Reference Laboratory Aberdeen Medicine, Promotion and Preventative Sponsor: MD. Ground, Proving B. Doctor B. DETECTION OF MODIFICATIONS OF DETECTION OF MODIFICATIONS TISSUE THIOLS IN COMPLEX PROTEIN University of Arizona, Tucson, AZ. Tucson, Arizona, of University AND BCHE ACHE COMPARATIVE WHOLE BLOOD WRAIR THE METHODS: MICHEL OP SYSTEM, TEST-MATE ASSAY, Processing, Battelle, Richland, WA, WA, Processing, Battelle, Richland, Institute, Columbus, OH and of Biochemical Pharmacology, Walter Reed Army Army Reed Walter of Biochemical Pharmacology, Spring, MD, Institute of Research, Silver of Agricultural and Biosystems Engineering, of AZ, Tucson, Arizona, of University Toxicology, University of Arizona, Tuscon, AZ. Tuscon, Arizona, of University Toxicology, THE UDP-GT TESTING OF PROFICIENCY THE MALE IN THYROXINE FOR ASSAY Deck, S. T. Johnson, D. Lusiak, J. D. B. F344 RAT. Center, Technical . Chemistry Burback and B. Graves Battelle Memorial Institute, Columbus, OH. NUCLEAR MAGNETIC ONE-DIMENSIONAL FOR SPECTROSCOPY RESONANCE THE DETECTION OF INFLAMMATORY ENVIRONMENTAL TO BIOMARKERS DUE A. Hood C. AIR CONTAMINANTS.
(Continued) Annual Annual th 9:00 AM to 12:00 NOON 9:00 Room 6A TOOLS METHODS & BIOMARKERS: POSTER SESSION: and Steven NIOSH, Cincinnati, OH Cheever, Kenneth Chairperson(s): KY. Louisville, of Louisville, University Myers, NOON AM–12:00 9:00 Displayed: AM–12:00 NOON Attended: 10:30 #2349 Thursday, March 9 March Thursday, #2351 #2350 #2352 #2353 45 248 . 2 Meeting & ToxExpo & Meeting , 1 M. . 3 . 2 Gradient 2 . B. D. Beck D. and B. 1 BCMB, University University BCMB, , R. M. Carlson 1 1 Zoology, Un. of Zoology, . Consumer Product 2 1 2 Rutgers University, Rutgers University, and S. Arshad and S. 3 2 and Z. Hejzlar 1 M. Zorbas , B. Danielewska- , B. I. C. Munro , S. Nitka 1 T. M. O’Brien T. T. A. Lewandowski A. T. V. R. Pinney V. K. B. Wallace and K. B. 2 X. Yan , X. 1 Environmental, Engineering Systems, Inc., Environmental, 2 . Toxicology, Engineering Systems, Inc., Ft. Myers, Engineering Systems, Inc., Ft. Myers, Toxicology, Limited Brands, Paramus, NJ, NJ, Limited Brands, Paramus, Gradient Corporation, Seattle, WA and and WA Gradient Corporation, Seattle, P. J. Oliveira J. P. Testing Co., Fairfield, NJ and Co., Fairfield, Testing FLUOROACETATE: SEARCH FOR FLUOROACETATE: A. Goncharov, N. THERAPY. EFFECTIVE RIHOPHE, A. Radilov. L. Glashkina and Kuznetsov, Sponsor: Russian Federation. Saint-Petersburg, 1 1 FL and . CANTOX Health A. Haighton. CANTOX Marshall and L. Canada. ON, Sciences Intl., Mississauga, OF MARGINS OF SAFETY COMPARISON TWO USING SUBSTANCES FOR FLAVORING DIFFERENT METHODS FOR ESTIMATION INTAKE. OF DAILY of Minnesota, Duluth, MN and of Minnesota, Duluth, MN A. John-Baptiste, AND NON-HUMAN SPECIES. sace, M. Malamant and B. F. Evering, W. Zong, Q. Pfizer Inc., Toxicology, WWSS - Gualdoni-Holmes. CA. Sponsor: San Diego, EVALUATION OF POTENTIAL LITHIUM OF POTENTIAL EVALUATION A WITH ASSOCIATED TOXICITY IN DEVICE USED MONITORING ELEPHANTS. 1 Dorato Piscataway, NJ. Piscataway, PRODUCTS; MICROPIGMENTATION ADVERSE THE RISK OF REDUCING REACTIONS. Ft. Myers, FL. Ft. Myers, Nikiel and W. Agmata. CANTOX Health Sciences Agmata. CANTOX W. Nikiel and Canada. ON, Intl., Mississauga, OF CHEMICAL EVALUATION AND DOSE-RESPONSE- INTERACTIONS A. E. IN EYE MAKEUP. RELATIONSHIP Choudhury THE SAFETY OF GREEN TEA EXTRACTS TEA EXTRACTS THE SAFETY OF GREEN WEIGHT LOSS WITH ASSOCIATED V. H. Leslie, K. Musa-Veloso, PRODUCTS. Corporation, Cambridge, MA. MECHANISM OF N-ACETYL SULFONAMIDE PERFLUOROOCTANE INDUCED MITOCHONDRIAL DYSFUNCTION. Coimbra, Coimbra, Portugal. OF HEMOCOMPATIBILITY VITRO IN WITH HUMAN CO-SOLVENTS VARIOUS 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#2344 #2346 #2341 #2348
#2347 Program Description Description Program #2345 #2342 #2343
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2354 THE DEVELOPMENT OF PROTEOMICS- #2363 THE IMPORTANCE OF PERFORMING BASED ACRYLAMIDE BIOMARKERS USING A KINETIC SIMULATION PRIOR TO SURFACE ENHANCED LASER DESORPTION INITIATION OF A KINETIC STUDY AND IONIZATION (SELDI). K. L. Cheever. Molecular VALIDATION OF A BIO-ANALYTICAL and Genetic Monitoring, NIOSH, Cincinnati, OH. METHOD. B. L. Burback1, J. O. Peggins2, S. Hong1, T. Kinsella3, S. Graves1, J. D. Johnson1, #2355 A RAPID APPROACH TO ESTIMATE N. L. South1, M. K. Pauff1, E. A. Psurny1 and I. HPRT MUTANT FREQUENCIES AND TO M. Grossi1. 1Chemistry Technical Center, Battelle CHARACTERIZE GENE MUTATIONS IN Memorial Institute, Columbus, OH, 2Developmental TOBACCO SMOKERS. A. Guerin, J. K. Wickliffe, Therapeutics, National Cancer Institute, Bethesda, C. E. Hill, J. R. Carmical, J. B. Ward and S. Z. MD and 3School of Medicine Ireland Cancer Center, Abdel-Rahman. University of Texas Medical Branch, Case Western Reserve University, Clevaland, OH. Galveston, TX. #2364 MUSCLE CROSS SECTION AREA AND #2356 SEPARATION OF TOXICOLOGICALLY BODY COMPOSITION DETERMINATION RELEVANT ARSENICALS IN URINE USING USING PQCT AND DEXA TECHNOLOGY IN A NEW SOLID PHASE EXTRACTION CYNOMOLGUS MONKEYS. M. Niehoff and G. 1 2 TECHNIQUE. B. M. Adair , V. Devesa-Perez , M. F. Weinbauer. Covance, Muenster, Germany. Styblo3, 2 and D. J. Thomas1. 1ORD/NHEERL/ETD, U.S. EPA, Research Triangle Park, NC, 2CEMALB, UNC, Chapel Hill, NC and 3Department of Thursday, March 9 Pediatrics, UNC, Chapel Hill, NC. 9:00 AM to 12:00 NOON Room 6A #2357 IN VITRO MODEL OF HEMOLYSIS USING WHOLE BLOOD-LIVER SLICE CO- POSTER SESSION: PHYSIOLOGICALLY-BASED MODELS: CULTURES. W. Way and A. E. Vickers. Drug DEVELOPMENT AND EVALUATION Safety Evaluation, Allergan Inc., Irvine, CA. Chairperson(s): Jeffrey Fisher, University of Georgia, Athens, GA and #2358 THE USE OF DRIED BLOOD SPOTS Kannan Krishnan, University of Montréal, Montréal, QC, Canada. FOR MEASURING 1, 4-BENZOQUINONE ADDUCTS IN HUMAN ALBUMIN. W. E. Funk, Displayed: 9:00 AM–12:00 NOON S. Waidyanatha and S. M. Rappaport. Environmental Science & Engineering, University of North Attended: 9:00 AM–10:30 AM Carolina, Chapel Hill, NC. Sponsor: L. Ball. #2365 DEVELOPMENT OF A PHYSIOLOGICALLY #2359 CHARACTERIZATION OF TOBACCO- BASED PHARMACOKINETIC MODEL SPECIFIC NITROSAMINE HEMOGLOBIN FOR DELTAMETHRIN IN ADULT AND ADDUCTS IN SMOKING MOTHERS DEVELOPING SPRAGUE-DAWLEY RATS. 1 2 2 2 AND NEW BORN BABIES BY MASS A. Mirfazaelian , K. Kim , S. S. Anand , H. J. Kim , 3 2 1 SPECTROMETRY. S. R. Myers and M. Y. R. Tornero-Velez , J. V. Bruckner and J. W. Fisher . 1 Ali. Pharmacology and Toxicology, Center for Department of Environmental Health Science, 2 Environmental and Occupational Health Sciences, University of Georgia, Athens, GA, Department of University of Louisville, Louisville, KY. Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA and 3National Exposure #2360 METHOD VALIDATION FOR THE Research Laboratory, U.S. EPA, Research Triangle EVALUATION OF ABERRANT CRYPT FOCI Park, NC. IN AZOXYMETHANE-TREATED RATS. A. Adamou, S. Groom and E. Jacquinet. Toxicology, #2366 PHYSIOLOGICALLY-BASED Charles River Laboratories Preclinical Montréal, PHARMACOKINETIC (PBPK) MODELING 1 1 Senneville, QC, Canada. Sponsor: C. Banks. OF RDX IN RATS. M. A. Major , G. Reddy and K. Krishnan2. 1US Army Center for Health Promotion #2361 DETECTION OF NANOSIZE PARTICLES and Preventive Medicine, Aberdeen Proving Ground, IN LIVING CELLS USING AN ADVANCED MD and 2SEST, University of Montréal, Montréal, ILLUMINATING SYSTEM MICROSCOPE. QC, Canada. S. Hussain, J. Skebo and J. Schlager. Applied Biotechnology/HEPB, Air Force Research #2367 HARMONIZED PBPK MODELS FOR JP-8 Laboratory, Wright-Patterson AFB, OH. COMPONENTS NONANE AND DECANE. P. J. Robinson1, E. A. Merrill1, D. R. Mattie1, Universtiy #2362 POLYCOLONAL ANTIBOBY DEVELOPMENT of. R. Perleberg2 and J. W. Fisher2. 1HEPB, Air FOR STYRENE OXIDE CYSTEINYL Force Research Laboratory, Dayton, OH and PROTEIN ADDUCT DETECTION. W. 2Environmental Health Science, University of Yuan1, J. Chung1, S. Gee2, B. D. Hammock2 Georgia, Athens, GA. and J. Zheng1. 1Department of Pharmaceutical Sciences, Northeastern University, Boston, MA #2368 A PBPK MODEL FOR THREE 1 and 2Department of Entomology, University of DIHALOACETATES. M. Easterling , J. L. 1 2 2 1 California, Davis, CA. Matthews , R. L. Melnick and C. Smith . Constella Group, Durham, NC and 2NIEHS, Research Triangle Park, NC. up-to-date information at www.toxicology.org 249
1 , 3 . 3 Food Food 1 , E. 1 . 2 M. V. Evans V. , M. 1 , C. Eklund G. and G. , W. A. Chiu W. , 1 1 NCEA, U.S. NCEA, U.S. NHEERL, U.S. NHEERL, U.S. 3 2 Summit 1 U.S. EPA, EPA, U.S. 2 . 2 and C. Chen 5 J. Bessems J. Annual Meeting Annual Anteon Corp, LV, NV. Anteon Corp, LV, NCEA, U.S. EPA, EPA, NCEA, U.S. 3 th 4 K. Krishnan , F. W. Power W. , F. ORD/NHEERL, U.S. EPA, EPA, ORD/NHEERL, U.S. , 2 M. F. Hughes , M. F. 2 and V. Benignus V. and 2 , J. N. Blancato N. , J. 1 2 NCCT, U.S. EPA, Research EPA, U.S. NCCT, 5 SOT's 45 SOT's U.S. EPA, Research Triangle Park, Park, Triangle Research EPA, U.S. , J. N. Blancato N. , J. 1 4 . 3 Work Environment Toxicology, Toxicology, Environment Work 2 Occupational and Environmental Occupational and Environmental and R. S. DeWoskin 1 1 M. V. Evans V. , M. . 1 2 , J. Lammers , J. E. M. Kenyon , L. Ernstgard 1 1 ). V U.S. EPA, LV, NV and LV, EPA, U.S. 2 NERL, U.S. EPA, Las Vegas, NV, NV, Vegas, Las EPA, NERL, U.S. Research Triangle Park, NC. Park, Triangle Research A PHYSIOLOGICALLY-BASED (PBPK) MODEL PHARMACOKINETIC ETHER BUTYL TERTIARY FOR METHYL EVALUATION OF INTERSPECIES EVALUATION DIFFERENCES IN PHARMACOKINETICS THE A PBPK MODEL FOR (PK) USING ACID PESTICIDE DIMETHYLARSINIC EPA, Research Triangle Park, NC, Park, Triangle Research EPA, Johanson (DMA EPA, U.S. Evans. ORD/NHEERL/ETD, V. and M. NC. Park, Triangle Research EVALUATE TO PHYSIOLOGICAL MODEL ON ACTIVITIES EFFECTS OF PHYSICAL TOLUENE. KINETICS OF Heugens Zeist, Netherlands and A. Nong Canada and M. Okino 1 Cincinnati, OH and PBPK MODELLING FOR LINDANE: LINDANE: PBPK MODELLING FOR AND STRUCTURE OF MODEL IMPACT ON MODEL UTILITY. PARAMETERIZATION Netherlands. PHYSIOLOGICAL REALISM IMPROVED VARIABILITY FOR IN PBPK MODELING WITH ETHANOL. A CASE STUDY ANALYSIS: S. M. Hays Power W. (MTBE). F. NC, Research Triangle Park, NC. Park, Triangle Research THE INHALATION OF ANALYSIS BAYESIAN OF METHYL PHARMACOKINETICS AND ITS ETHER (MTBE) TERT-BUTYL IN HUMANS. TERT-BUTANOL METABOLITE Toxicology, Allenspark, CO and Allenspark, CO and Toxicology, J. C. Lipscomb J. EPA, Washington DC, DC, Washington EPA, and M. Reddy. Institute for Risk and M. Reddy. Blaauboer B. Utrecht, University, Assessment Sciences, Utrecht Tsang A. and and Chemical Risk Analysis, TNO Quality of Life, Analysis, and Chemical Risk Health, University de Montréal, Montréal, QC, de Montréal, Montréal, Health, University Triangle Park, NC. Park, Triangle Karolinska Institutet, Stockholm, Sweden. OF MULTIPLE EVALUATION MODELING PHARMACOKINETIC TRICHLOROETHYLENE. FOR STRUCTURES
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1 1 CIIT 2 , , J. , J. 2 C. J. and C. J. 1 J. Pittman J. J. F. Nash F. J. , H. T. Tran T. , H. , J. D. Tessari D. , J. University of University CIIT, Centers for CIIT, 1 2 1, 2 . 3, 1 1 Syracuse Research Toxicology and Toxicology 2 Constella Group, 1 1 . , A. R. Craigmill . 2 2 , E. H. Lebetkin 1 Battelle PNNL-Marine 2 , M. R. Easterling 1 Department of Mathematics 1 Central Product Safety, Procter Central Product Safety, . 1 . 2, 3 2 NIEHS, Research Triangle Park, Park, Triangle NIEHS, Research T. S. McMullin , T. 2 A. E. Melvin 3 J. W. Fisher W. and J. 2 NCEA, U.S. EPA, Washington, DC. Washington, EPA, NCEA, U.S. A. R. Campbell
3 and C. J. Portier and C. J. 3 2 , M. V. Smith V. , M. , M. R. Easterling 1 Constella Group, LLC, Durham, NC and 1 1 . 2 , I. R. Schultz 1 NIEHS, Research Triangle Park, NC. Park, Triangle NIEHS, Research Radiological and Environmental Health Sciences, and Environmental Radiological Centers for Health Research, Research Triangle Triangle Centers for Health Research, Research NC and Park, Georgia, Athens, GA and Georgia, and Center for Research in Scientific Computation, Raleigh, NC, North Carolina State University, Environmental Research and Consulting, The Dow The Dow Research and Consulting, Environmental MI, Midland, Chemical Company, W. H. Hanneman H. W. Li 2 . Mississippi State University, . Mississippi State University, Chambers and J. Starkville, MS. A HUMAN PBPK DEVELOPMENT OF T. ACID. MODEL FOR DICHLORAOCETIC WA. Research Operations, Sequim, AND VALUES PARAMETER ESTIMATING L. IN PBPK MODELING. J. VARIANCES Matthews G. L. Diamond and G. P. M. Schlosser and P. Colorado State University, Fort Collins, CO. Fort Colorado State University, BASED PHYSIOLOGICALLY A SERIES MODELS FOR TOXICOKINETIC DIPHENYL ETHERS. J. OF BROMINATED R. Pirone M. Sanders Durham, NC and NC. MODEL BASED PHYSIOLOGICALLY AND PARAMETER DEVELOPMENT IRRITATION RESPIRATORY ESTIMATION: Yokley K. RESPONSE IN RATS. 3 PBPK MODEL FOR A TOXIC METABOLITE METABOLITE TOXIC A PBPK MODEL FOR MODELING TISSUE: IN EXTRAHEPATIC TOXICANT TESTICULAR THE WITH MOLINATE. Portier & Gamble, Cincinnati, OH and & Gamble, Health Research, Research Triangle Park, NC and Park, Triangle Health Research, Research A PHYSIOLOGICALLY-BASED A PHYSIOLOGICALLY-BASED OF (PBPK) MODEL PHARMACOKINETIC THE RAT. ZINC PYRITHIONE IN Corporation, Syracuse, NY. A PHYSIOLOGICALLY- DEVELOPMENT OF AND TOXICOKINETIC BASED (PBTK/TD) MODEL TOXICODYNAMIC ORGANOPHOSPHORUS TERNARY A FOR INSECTICIDE MIXTURE IN RATS. . Environmental Miller . Environmental and M. G. Phillips W. CA. Davis, UC Davis, Toxicology, DESCRIBE TO A PHYSIOLGICAL MODEL AND OXIDATIVE ABSORPTION AND ITS ATRAZINE OF METABOLISM IN RAT. METABOLITES CHLOROTRIAZINE B. Cranmer B. 45th Annual Meeting and ToxExpo and Meeting Annual 45th
#2375 #2376 #2371 #2372
#2369 Program Description Description Program #2373 #2374 #2370
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY Thursday, March 9 #2390 AUTOMATED LIQUID-LIQUID 9:00 AM to 12:00 NOON EXTRACTION AND LC/MS/MS DETECTION Room 6A FOR THE DETERMINATION OF TACROLIMUS IN HUMAN EDTA K3 WHOLE POSTER SESSION: ANALYTICAL TOXICOLOGY BLOOD. N. Jean, M. Theberge, J. Couture and F. Vallee. Bioanalytical, SFBC Anapharm Inc., Ste-Foy, Chairperson(s): Robert Tardif, University of Montréal, Montréal, QC, QC, Canada. Sponsor: M. Charbonneau. Canada. #2391 LC/MS/MS METHOD FOR THE ANALYSIS
Displayed: 9:00 AM–12:00 NOON OF ENTACAPONE IN HUMAN EDTA K3 PLASMA. A. Beaulieu, M. Marcoux, J. Couture and Attended: 10:30 AM–12:00 NOON F. Vallee. Bioanalytical, SFBC Anapharm Inc., Ste- Foy, QC, Canada. Sponsor: M. Charbonneau. #2384 ACCELERATOR MASS SPECTROMETRY AS A TOOL FOR METABOLITE PROFILING STUDIES USING AMBIENT LEVELS OF Thursday, March 9 RADIOACTIVITY. B. Faulkner1, 4, B. W. Wilson1, 9:00 AM to 12:00 NOON B. L. Lasley2, J. S. Vogel3 and S. R. Dueker4. Room 6A 1Environmental Toxicology, University of California, Davis, CA, 2Population and Reproductive Biology, POSTER SESSION: LIVER III University of California, Davis, CA, 3Lawrence Livermore National Laboratory, Livermore, CA and Chairperson(s): Kelly Hall, University of South FL, Tampa, FL. 4Vitalea Science Inc., Davis, CA. Displayed: 9:00 AM–12:00 NOON #2385 A COMPARISON OF WHOLE BLOOD, PLASMA AND SERUM EVALUATIONS Attended: 9:00 AM–10:30 AM FOR THE DETERMINATION OF #2392 CHARACTERIZATION OF COMPOUND- PERFLUOROOCTANESULFONATE (PFOS), INDUCED HEPATOTOXICITY USING GENE PERFLUOROOCTANOATE (PFOA), AND EXPRESSION PROFILING IN RAT PRIMARY PERFLUOROHEXANESULFONATE (PFHS) HEPATOCYTES. G. Day1, L. Brady1, T. P. Ryan2, IN HUMAN SUBJECTS. D. Ehresman1, J. G. H. Searfoss2, R. H. Jolly2, K. Goldstein2, B. Froehlich2, G. Olsen1, S. Tanaka1 and J. Butenhoff1. Eynon1, M. Fielden1, J. Ferng1, S. Fujimoto1, K. 13M Company, St. Paul, MN and 2University of Jarnagin1, K. Kolaja1 and D. N. Halbert1. 1Iconix California, Davis, CA. Pharmaceuticals, Inc., Mountain View, CA and 2Lilly Research Laboratories, Indianapolis, IN. #2386 DEVELOPMENT OF A SPME-HEADSPACE METHOD FOR TISSUE ANALYSIS AND #2393 CHARACTERIZATION OF ALTERATIONS IN DISPOSITION OF SELECTED JP-8 RAT LIVER MICROARRAY DATA INDUCED HYDROCARBONS IN RATS EXPOSED TO BY TISSUE HANDLING. P. Pine1, B. A. JP-8 VAPOR. J. L. Campbell, M. Ortiz-Serrano, Rosenzweig1, Y. Turpaz2 and K. Thompson1. 1CDER, L. Myers, E. McLanahan, M. Henderson and J. USFDA, Silver Spring, MD and 2Affymetrix Inc., Fisher. Environmental Health Science, University of Santa Clara, CA. Georgia, Athens, GA. #2394 PROTEOMIC AND METABONOMIC #2387 REALIZING THE POWER OF LIQUID CHARACTERIZATION OF THE EFFECTS CHROMATOGRAPHY/TANDEM OF A G-PROTEIN COUPLED RECEPTOR MASS SPECTROMETRY (LC/MS/MS): ANTAGONIST IN RAT LIVER. J. M. Morsman, QUALITATIVE AND QUANTITATIVE N. Bowen, S. J. Byard and V. A. Baker. Sanofi- TOXICOLOGICAL ANALYSIS OF STEROIDS. Aventis, Alnwick, Northumberland, United J. A. Ferguson and J. D. Miller. Applications Kingdom. Sponsor: A. Roberts. Laboratory, Applied Biosystems, Framingham, MA. Sponsor: M. Lawton. #2395 PROTEOMIC ANALYSIS OF RAT LIVER FOLLOWING CHRONIC TREATMENT #2388 ANALYSIS OF LINEZOLID IN HUMAN WITH TAMOXIFEN AND PHENOBARBITAL. EDTA K2 PLASMA BY LC/MS/MS USING R. Edmondson, R. C. Jones, R. D. Holland, J. T. AUTOMATED SPE EXTRACTION. R. Dumas, Taylor, S. Thyparambil and Y. P. Dragan. Division of B. Pellerin, J. Couture and F. Vallee. Bioanalytical, Systems Toxicology, NCTR, Jefferson, AR. SFBC Anapharm Inc., Ste-Foy, QC, Canada. Sponsor: M. Charbonneau. #2396 IRON HOMEOSTASIS IN DIETHYLNITROSAMINE-INDUCED MOUSE #2389 LC/MS/MS METHOD FOR THE ANALYSIS LIVER TUMORS. D. Ryu1, E. Jung1 and J. Park2. 1 OF MONTELUKAST IN HUMAN EDTA K3 Research Institute for Veterinary Science, College PLASMA. E. Morin, B. Pellerin, J. Couture and F. of Veterinary Medicine, Seoul National University, Vallee. Bioanalytical, SFBC Anapharm Inc., Ste-Foy, Seoul, South Korea and 2College of Medicine, QC, Canada. Sponsor: M. Charbonneau. Chungang University, Seoul, South Korea.
up-to-date information at www.toxicology.org 251 R.
M. , C. , C. M. 2 , Pathology, Pathology, , C. H. 2 2 , C. Muro- K. W. Hall W. , K. Microbiology & Microbiology , A. S. Gleit , 1 N. N. Patel N. N. 1 . 2 P. Grivas , P. Annual Meeting Annual th , T. R. Tannert R. T. , Pharmaceutical Sciences, 2 1 . 2 K. Hall C. Grivas P. SOT's 45 SOT's P. J. J. and TchaoP. , R. Patel N. , N. G. A. Ansari A. and G. 2 , K. E. Klingler . College of Public Health, Health, of Public R. Harbison. College 2 . , P. Cai , P. 1 and J. R. Harkness and J. 2 Ohio Northern University, Ada, OH. Sponsor: Ohio Northern University, S. A. Zank S. LIVER TOXICITY OF DICHLOROACETYL OF DICHLOROACETYL TOXICITY LIVER AND DICHLOROACETIC CHLORIDE DIFFERENTIAL GENE ANHYDRIDE: UTMB, Galveston, TX. Galveston, UTMB, ALTERATION 6(5-H) PHENANTHRIDINONE OF BROMOBENZENE-INDUCED HEPATOTOXICITY. THIAZOLIDINEDIONE (DCPT)-INDUCED THIAZOLIDINEDIONE (DCPT)-INDUCED IN RATS. HEPATOTOXICITY Harvison. Department J. and P. Tchao Crincoli, R. of the of Pharmaceutical Sciences, University Sciences in Philadelphia, Philadelphia, PA. HEPATOTOXICITY COMPARATIVE 4- 5-DICHLOROPHENYL)-2, OF 3-(3, THIAZOLIDINEDIONE (DCPT) IN MALE AND FEMALE FISCHER 344 (F344) RATS. C. M. Crincoli Harvison. Department of Pharmaceutical Sciences, of the Sciences in Philadelphia, University Philadelphia, PA. BODY AGE, EFFECTS OF RELATIVE AND/OR ETHANOL ON DIET, WEIGHT, INSULIN TO BLOOD GLUCOSE RESPONSE Knecht T. WHITE MICE. K. IN Kim 2 Kadiiska EXPRESSION IN FEMALE MRL+/+ MICE. EXPRESSION IN FEMALE Konig Cacho and INHIBITION AMINOPHYLLINE-INDUCED TETRACHLORIDE-INDUCED OF CARBON HEPATOTOXICITY. Harbison. Environmental A. Muro-Cacho and R. D. of Public and Occupational Health, USF College FL. Tampa, Health, SUBSTITUENTS AROMATIC EFFECT OF 4- 5-DICHLOROPHENYL)-2, ON 3-(3, Loma Linda University, Loma Linda, CA and Loma Linda University, Univeristy of South Florida, Tampa, FL. Tampa, South Florida, of Univeristy Immunology, UTMB, Galveston, TX and Galveston, UTMB, Immunology,
(Continued) Annual Annual th #2405 #2406 #2409 #2410 #2408 #2407 45 252 Meeting & ToxExpo & Meeting 2, .
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, R. , F. , F. J. K. and J. 1 1, 3 Department 1 . , F. A. Simmen , F. , D. G. , D. 1, 3 3 2 Physiology & Physiology 1 , C. D. Fisher , C. D. , L. He . 1 Arkansas Children’s Arkansas Children’s R. Forster 3 1, 3 J. E. Manautou , J. 2, 3 1 School of Biosciences, D. R. Petersen and D. 2 Pharmacology & Pharmacology C. J. Powell , C. J. 2 1, 2 TOTAL ENTERAL TOTAL VIA Pharmacology and Pharmacology , B. Mickle and R. Gallucci, B. 1
. 1 Arkansas Children’s Nutrition Arkansas Children’s 3 , C. M. Skinner M. J. Ronis and M. J. 3 L. M. Aleksunes , L. M. 1 T. M. Badger T. 2, 3, 1 M. J. Ronis and M. J. C. J. Broccardo C. J. Safety Assessment, GlaxoSmithKline, Safety 1, 3 1 A. J. Winkley A. J. . , A. Bhattacharyya , , X. Liu . Department of R. Petersen and D. . 1 2 1, 3 Pharmaceutical Sciences, University of Pharmaceutical Sciences, University 2 T. M. Badger , T. UAMS, & Biophysics, Departmentof Physiology Center, Little Rock, AR. Little Rock, Center, Toxicology, University of Arizona, Tucson, AZ Tucson, Arizona, of University Toxicology, L. M. Augustine L. M. Pharmaceutical Sciences, University of Colo. at of Colo. Pharmaceutical Sciences, University CO. Denver, & Health Sciences Center, Denver A. Simmen Shankar 3 2 AR and Little Rock, GENDER DIFFERENCES IN LIVER IL-6 ALCOHOL EXPRESSION IN RECEPTOR CONSUMING RATS. N. J. Cherrington J. and N. and Kingdom. RENAL AND HEPATIC ALTERED IN DIET-INDUCED TRANSPORT EFFLUX MODELS OF NON-ALCOHOLIC FATTY A. Lickteig LIVER DISEASE. Besselsen THE INFLUENCE OF KUPFFER CELL/ THE INFLUENCE OF ON INTERACTION HEPATOCYTE AND ENDOTOXIN-INDUCED ETHANOL EXPRESSION AND GENE HEPATOTOXICITY VITRO IN Chipman EFFECT OF METHAPYRILENE, A MODEL EFFECT OF METHAPYRILENE, GENE HEPATIC ON HEPATOTOXICANT, THE RAT. EXPRESSION IN NUTRITION INDUCES ALCOHOL NUTRITION INDUCES AND INSULIN (ADH) DEHYDROGENASE RESISTANCE. L. Reinke. PharmaceuticalL. Reinke. Sciences, OU Health OK. Oklahoma City, Sciences Center, ALCOHOL- FEEDING CHRONIC DIETS CONTAINING El Gana, S. Arthaud, C. Fisch, S. Leuillet, S. de C. Fisch, Arthaud, El Gana, S. France. Evreux, Ancian. CIT, P. and Jouffrey PROTEOMIC 2D-DIGE:A LARGE SCALE DIFFERENCES OF GENDER ANALYSIS IN NAFLD. United Kingdom and Ware, Pharmaceutical Sciences, UCDHSC, Denver, CO. Pharmaceutical Denver, Sciences, UCDHSC, B. Stewart B. Nutrition Center, Little Rock, AR. Little Rock, Nutrition Center, ALCOHOLIC MEDIATE SREBP-1 DOES NOT FEEDING MODEL. A RAT IN STEATOSIS Connecticut, Storrs, CT. A DETERMINANT IS STATUS NUTRITIONAL GENE OF ETHANOL-INDUCED HEPATIC EXPRESSION DURING GESTATION. University of Birmingham, Birmingham, University United Toxicology, University of Arkansas for Medical of University Toxicology, AR and Sciences, Little Rock, of Pharmacology & Toxicology, University of University Toxicology, & of Pharmacology AR, Arkansas for Medical Sciences, Little Rock, Biophysics, University of Arkansas for Medical of University Biophysics, AR, Sciences, Little Rock, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#2399 Program Description Description Program #2404 #2401
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY Thursday, March 9 #2417 CHRONIC FORCED EXERCISE 9:00 AM to 12:00 NOON ATTENUATES KAINIC ACID-INDUCED Room 6A NEUROTOXICITY INDEPENDENT OF CHANGES IN PLASMA OR BRAIN LEVELS POSTER SESSION: NERVOUS SYSTEM: MECHANISMS AND OF INSULIN-LIKE GROWTH FACTOR-1. S. EFFECTS A. Benkovic, J. P. O’Callaghan and D. B. Miller. TMBB, CDC-NIOSH, Morgantown, WV. Chairperson(s): Stanley Benkovic, CDC-NIOSH, Morgantown, WV and #2418 Mohammed Sabri, OHSU, Portland, OR. COMPARISON OF GENE EXPRESSION CHANGES IN THE STRIATUM, CORTEX Displayed: 9:00 AM–12:00 NOON AND HIPPOCAMPUS OF RATS TREATED WITH AN ESCALATING DOSE-BINGE Attended: 10:30 AM–12:00 NOON METHAMPHETAMINE (METH) REGIMEN. D. L. Graham1, 2, P. H. Noailles2, O. Asanbe2, K. G. #2411 DIFFERENTIAL EFFECTS OF CARBARYL Becker3, W. H. Wood3, V. Prabhu3 and J. L. Cadet2. ON BRAIN ACONITASE ACTIVITY IN 1Program in Toxicology, University of Maryland SPONTANEOUSLY HYPERTENSIVE (SHR) School of Medicine, Baltimore, MD, 2Molecular AND WISTAR-KYOTO (WKY) RATS. P. Neuropsychiatry Branch, DHHS/NIH/NIDA/IRP, R. Kodavanti1, T. R. Ward1, J. Richards2, M. C. Baltimore, MD and 3Gene Expression and Genomics Schladweiler2, Universtiy of. P. Kodavanti2, J. D. Unit, DHHS/NIH/NIA/GRC, Baltimore, MD. Farmer1 and R. C. MacPhail1. 1Neurotoxicology Division, U.S. EPA, Research Triangle Park, NC #2419 A THRESHOLD NEUROTOXIC EXPOSURE and 2Experimental Toxicology Division, U.S. EPA, TO AMPHETAMINE DISRUPTS CORTICAL Research Triangle Park, NC. SYNAPTIC NEUROPLASTICITY. J. F. Bowyer1, A. R. Pogge1, R. R. Delongchamp2, J. #2412 MECHANISM OF βB-BUNGAROTOXIN IN P. O Callaghan4, K. M. Patel3, K. E. Vrana3 and THE FACILITATION OF SPONTANEOUS W. M. Freeman3. 1Neurotoxicology, NCTR/U.S. TRANSMITTER RELEASE AT DEVELOPING FDA, Jefferson, AR, 2Biometry, NCTR/U.S. FDA, NEUROMUSCULAR SYNAPSE. J. Liou. Jefferson, AR, 3Pharmacology, Penn State College Department of Biological Sciences, National Sun of Medicine, Hershey, PA and 4Toxicology and Yat-sen University, Kaohsiung city, Taiwan. Sponsor: Molecular Biology, CDC-NIOSH, Morgantown, WV. C. Chou. #2420 ACRYLAMIDE ALTERS SELECTIVE #2413 MICE DEFICIENT IN CYCLOOXYGENASE-2 ISOZYMES OF PROTEIN KINASE C IN ARE MORE SUSCEPTIBLE THAN WILD- NEURONAL CELLS IN CULTURE. J. Yang, H. TYPES TO KAINIC ACID EXCITOTOXICITY. Lee, S. Kim and E. Choi. Pharmacology/Toxicology, C. D. Toscano and F. Bosetti. National Institute on Catholic University of Daegu, Daegu, South Korea. Aging/ Brain Physiology and Metabolism Section, Sponsor: P. Kodavanti. National Institutes of Health, Bethesda, MD. #2421 ACRYLAMIDE ADDUCT FORMATION IN #2414 CHARACTERIZATION OF ERK ACTIVITY NERVE TERMINALS. S. Stevens1, D. S. Barber2 IN DEVELOPING CULTURES OF and R. M. LoPachin3. 1Protein Chemistry Core, NEOCORTICAL CELLS. B. L. Robinette and W. University of Florida, Gainesville, FL, 2Center for R. Mundy. Neurotoxicology, U.S. EPA, Research Environmental and Human Toxicology, University of Triangle Park, NC. Florida, Gainesville, FL and 3Anesthesiology, Albert #2415 ANTIOXIDANT RESPONSE ELEMENT Einstein College of Medicine, Bronx, NY. SIGNALING IN NEURAL PROGENITOR #2422 EFFECT OF A NONSELECTIVE CELLS AND GRAFTS; POTENTIAL PROTEASOME INHIBITOR MLN273 ON PROTECTION AGAINST NEUROTOXICANTS.
M. Calkins1, 2, J. Li4, D. A. Johnson2 and J. A. DIFFERENTIATED PC12 NEURONAL CELLS. V. Csizmadia, V. J. Kadambi, C. Eva, S. Coleman, Johnson1, 2, 3. 1Molecular and Environmental S. Barros, J. Pierce, A. Raczynski, S. Das, S. Toxicology Center, University of Wisconsin, Badola and C. Alden. Drug Safety and Disposition, Madison, WI, 2School of Pharmacy, University Millennium Pharmaceuticals, Inc., Cambridge, MA. of Wisconsin, Madison, WI, 3Waisman Center, University of Wisconsin, Madison, WI and 4Hartwell #2423 PROTEASOME INHIBITON INDUCED Center for Bioinformatics and Biotechnology, St. PERIPHERAL NEUROPATHY IN BALB/C Jude Children’s Research Hospital, Memphis, TN. MICE. L. Silverman, V. Csizmadia, K. Cardoza, M. Gallacher, M. Windman, M. Murnane, E. #2416 EVALUATING THE CONTRIBUTION OF Csizmadia, A. Bissonnette, S. Coleman, J. Pierce, NMDA AND KAINATE TYPE GLUTAMATE J. Lane, V. J. Kadambi and C. Alden. Drug Safety RECEPTORS TO PATTERN-ELICITED and Disposition, Millennium Pharmaceuticals, Inc., VISUAL EVOKED POTENTIALS IN LONG- Cambridge, MA. EVANS RATS. W. K. Boyes1, M. Bercegeay1, K. W. Johnson2, D. Bleakman2 and J. M. Witkin2. #2424 2, 5-HEXANEDIONE REDUCES DELIVERY 1Neurotoxicology Division, U.S. EPA, Research OF PROTEINS TO NEUROMUSCULAR Triangle Park, NC and 2Eli Lilly & Company, JUNCTIONS FOLLOWING SUBACUTE OR Indianapolis, IN. SUBCHRONIC EXPOSURE. D. Sickles and A. Testino. Medical College of Georgia, Augusta, GA. up-to-date information at www.toxicology.org 253 . .
1 P. , P. 2 . 7, T. T. , 4 , X. 3 M. R. Physiology Physiology , Y. Sun Y. , 1 4 Neuroscience, , H. Wang , H. . 3 2 L. Opanashuk 6, 1 and , E. Shibata Yixing Center Yixing 2 5 2, 3 and 3 Occupational and 1 Annual Meeting Annual D. A. Cory-Slechta , D. Veterans Affairs, Affairs, Veterans , B. Shao , B. . 2 2 4 th 1 , W. Li W. , 1 K. Harada and A. Koizumi , S. Ichihara 5 Pharmacology and Toxicology, Toxicology, and Pharmacology , M. A. King , M. 3 , Y. Tang Y. , D. G. Baden G. and D. 4 1 Aichi Medical University, Aichi Medical University, Fundan University School of Fundan University 3 4 1, 2 SOT's 45 SOT's Environmental and Occupational Environmental 2 G. Ichihara G. , S. Peng , R. D. Fitzpatrick , R. D. 3 , B. Gu , B. and Y. Takeuchi Y. and Guangdong Prevention and Treatment Treatment and Guangdong Prevention 4, 2 1 College of Pharmacy, Florida A&M Florida of Pharmacy, College 1 7 , Z. Cao 1 M. Thiruchelvam , M. 1 1 Center for Marine Science Research, UNC . R. Khalil 2 1
, J. Li , J. 2 Mie University Functional Genomics Institute, Tsu, Institute, Functional Genomics Mie University of Rochester, Medicine, University Environmental , F. Huang , F. Research, Shanghai Institute of Planned Parenthood Wilmington, Wilmington, NC. Wilmington, Wilmington, Medical Center, Gainesville, FL and Medical Center, J. Kostyniak J. Environmental Health, Nagoya University Graduate Graduate University Health, Nagoya Environmental Aichi, Japan, School of Medicine, Nagoya, University, Tallahassee, FL, Tallahassee, University, Rochester, NY, NY, Rochester, Department of Health and Environmental Sciences, Department of Health and Environmental Japan. Kyoto, University, Kyoto THE BRAIN IN ACCUMULATION PCB OXIDATIVE HYPERACTIVITY, PRODUCES AND MIDBRAIN NEURONAL STRESS, FOLLOWING MICE ADULT IN DEATH 1254 EXPOSURE. AROCLOR SUBCHRONIC D. W. Lee W. D. GA and 6 Japan and Center for Occupational Diseases, Guangzhou, China. EFFECT OF PERFLUOROOCTANE ACTION (PFOS) ON SULFONATE CEREBELLAR IN RAT POTENTIAL PURKINJE NEURON. 1 W Johnson Med. School, Medicine, UMDNJ-Robert NJ and Piscataway, Schaefer Hutchison, M. Beck, M. Nemec and G. TRANSIENT COGNITIVE DECLINE TRANSIENT COGNITIVE ETHANOL EXPERIMENTAL AN IN INDUCED RATS LONG EVANS MODEL IN HANGOVER HIPPOCAMPAL SEPTAL OF ROLE THE AND TRKA. Soliman Gainesville, FL. 1-BROMOPROPANE TO EXPOSURE VELOCITY CONDUCTION REDUCES NERVE IN HUMAN. Ding 1 M. Miyata 2 Shanghai, China, SUNY Buffalo, Buffalo, NY. Buffalo, SUNY Buffalo, THE PLACE OF VALIDATION A TO PREFERENCE CONDITIONING MODEL PROPERTIES THE REWARDING MEASURE Bucci, C. M. Herberth, P. IN RATS. OF DRUGS Public Health, Shanghai, China, Public for Disease Control and Prevention, Yixing, China, Yixing, for Disease Control and Prevention, WIL Research Laboratories, LLC, Ashland, OH. Ashland, WIL Research Laboratories, LLC, OF ACTIVATION BREVETOXIN-INDUCED SODIUM CHANNELS VOLTAGE-GATED OF PYK2 PHOSPHORYLATION AUGMENTS NEURONS. AND SRC IN NEOCORTICAL F. Murray F. and Pharmacology, University of Georgia, Athens, of Georgia, University and Pharmacology, Nagakute, Japan, Nagakute, College of Medicine, University of Florida, of Medicine, University College
(Continued) Annual Annual th #2436 #2435 #2433 #2434 #2437 #2438 45 254
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. M. and 2 and 2 J. E. J. , M. D. , M. D. T. J. Shafer J. T. T. J. Shafer J. , T. 1 1 D. Sickles and D. , S. Brodie 1 1 A. S. Bale Center for Functional
3 , R. M. LoPachin P. J. Bushnell J. , P. 1 1 , A. Testino A. , , S. J. Shost , S. J. 2 1 U.S. EPA, Research Triangle Triangle Research EPA, U.S. 1 . 1 Campbell University, Buies Creek, Campbell University, 2 Health, New York State, Troy, NY and Troy, State, York Health, New P. Spencer , P. 1 Environmental Health Sciences, Environmental 2 , Q. T. Krantz T. , Q. 1 . 2 2 . A. P. DeCaprio A. P. , K. A. Mazor , K. 3 Anesthesiology, Albert of Einstein College Anesthesiology, 1 2 Center for Research on Occupational and Center for Research on Occupational 2 Ophthalmology, Mt. Sinai School of Medicine, New Mt. Sinai School of Medicine, New Ophthalmology, Medical College of Georgia, Augusta, GA Augusta, of Georgia, Medical College University of Massachusetts Amherst, Amherst, Amherst, of Massachusetts University Q. Lin Q. Storm 2 . Neurotoxicology Division, Division, Bushnell. Neurotoxicology J. and P. Park, Triangle Research EPA, U.S. NHEERL, ORD, NC. SENSITIVITY CONTRAST VISUAL AMONG VISION COLOR AND (VCS) AND CHILD RESIDENTS OF ADULT CLEANER USING A DRY WITH BUILDINGS (PERC). PERCHLOROETHYLENE York. Jackson K. Boyes and W. NC. VOLTAGE- INHIBITS TRICHLOROETHANE SENSITIVE CALCIUM CURRENTS IN PC12 CELLS. DIFFERENTIATED . Toxicology Department, University of Department, University Toxicology A. Philbert. MI. Arbor, Ann Michigan, INHIBITION 3-NITROSONITROBENZENE DEHYDROGENASE OF PYRUVATE OF MODIFICATION THROUGH COMPLEX A. Philbert A. Miller and M. J. ACID. LIPOIC MA, Medicine, Bronx, NY and INDUCTION OF ENDOPLASMIC RETICULUM STRESS IN PRIMARY TO EXPOSURE FOLLOWING ASTROCYTES A. Runkle and S. 3-DINITROBENZENE. 1, 1 and 2, 5-HEXANEDIONE REDUCES SODIUM AND AND 5-HEXANEDIONE REDUCES SODIUM 2, NODES CHANNELS IN DISTAL POTASSIUM OR SUBACUTE OF RANVIER FOLLOWING and Testino A. INTOXICATION. SUBCHRONIC Augusta, of Georgia, . Medical College Sickles D. GA. OF KINESIN- SELECTIVE DISRUPTION BY MOTILITY MICROTUBULE BASED 2-DIACETYLBENZENE. 1, NEUROTOXIC J. Serle J. Environmental Health Sciences, University of Health Sciences, University Environmental MI. Arbor, Ann Michigan, THE NMDA-GLUTAMATE INHIBITION OF MAY TOLUENE BY RECEPTOR IN ALTERATIONS TO CONTRIBUTE EVOKED VISUAL ELICITED PATTERN IN RATS. POTENTIALS M. Sabri Genomics, University at Albany, Albany, NY. Albany, Albany, at Genomics, University Environmental Toxicology, Oregon Health & Health Oregon Toxicology, Environmental OR. Portland, Science University, ADDUCT PROTEIN NEUROFILAMENT CORD FRACTIONS IN SPINAL FORMATION 5-HEXANEDIONE INTOXICATED OF 2, RATS. Park, NC and Park, 45th Annual Meeting and ToxExpo and Meeting Annual 45th
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#2430 Program Description Description Program #2428 #2427
THURSDAY 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Continued)
Program Description THURSDAY #2439 EFFECTS OF THE TICK DERMACENTOR ANDERSONI TOXIN ON NEUROMUSCULAR FUNCTION IN MICE. C. B. Frank2, 1, N. E. Pardo1 and W. D. Atchison1, 2. 1Department Pharmacology/ Toxicology, Mich State University East Lansing, MI and 2Coll of Vet. Med., Mich State University East Lansing, MI. #2440 CELLULAR PRION TRANSDUCES NEUROPROTECTIVE SIGNALS VIA PI3K/ AKT PATHWAYS. K. J. Lee3, 1 and H. Jeong1, 2. 1Pharmacy, Chosun University, Kwangju, South Korea, 2Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea and 3Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD. #2441 PCB-INDUCED ALTERATIONS IN THE DOPAMINE TRANSPORTER AS A PRECURSOR TO NIGROSTRIATAL DOPAMINE DAMAGE. M. Caudle1, 2, J. R. Richardson1, 2, M. Z. Wang1, 2, K. D. Pennell3 and G. W. Miller1, 2. 1Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 2Environmental and Occupational Health, Emory University, Atlanta, GA and 3Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA. #2442 THE EFFECTS OF GLUTARALDEHYDE (GA) OR ORTHOPHTHALALDEHYDE (OPA) ON DOPAMINE METABOLISM IN THE HYPOTHALAMUS OF RATS AFTER INHALATION FOR FOUR WEEKS. M. Tsunoda1, T. Yamamoto2, H. Katagiri3, Y. Inoue1, K. Itoh1, M. Ikeda2, T. Satoh1, T. Kadowaki2, 3 and Y. Aizawa1, 2. 1Preventive Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan, 2Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan and 3Public Health, Kitasato University School of Allied Health Science, Sagamihara, Kanagawa, Japan.
up-to-date information at www.toxicology.org 255 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Notes
256 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index The numerals following the author’s names refer to the abstract numbers. The asterisk after the abstract number indicates the author is the first presenter.
A Alexander, D D ...... 2184 Anundi, H ...... 872 Auman, J T ...... 1081, 1093* Aardema, M ...... 44, 559 Alexander, M ...... 1846 Anwer, J ...... 1673 Auman, T ...... 462 Aarnaes, R C ...... 1369 Alexandrie, A ...... 1623 Ao, K ...... 1749 Ausman, K D ...... 1554 Abadin, H ...... 699, 892*, 2198 Alexeeff, G V ...... 723*, 882, Api, A ...... 813, 933, 938, 2271, 2275* Aust, A E ...... 240, 1357 Abbott, B D ...... 195, 369*, 370 ...... 899, 901*, 910, 2185 Apic, G ...... 1892* Autenrieth, R ...... 1250 Abbott, L C ...... 1782 Alexiadis, V ...... 1071 Aposhian, H V ...... 111* Authier, S ...... 582*, 1287, Abbott, M ...... 245 Aley, P ...... 2061 Apostolova, D B ...... 1043 ...... 1301, 2177 Abbott, M A ...... 253 Algaier, J W ...... 594 Appana, S ...... 1984 Auttachoat, W ...... 268, 274, Abd-Allah, A R ...... 1735 Ali, A M ...... 1165 Appel, M ...... 896 ...... 278, 2266* Abdel-Naim, A B ...... 575 Ali, M Y ...... 2359 Applegate, J ...... 1528, 763 Avalos, J ...... 482, 1602* Abdel-Rahman, A ...... 1447 Ali, S F ...... 1559 Aragon, A C ...... 2170* Avent, N D ...... 1956 Abdel-Rahman, S ...... 797 Allaben, W T ...... 1655 Aranibar, N ...... 161 Avila-Costa, M ...... 2061*, 2075, 2076 Abdel-Rahman, S Z ...... 701, 2355 Allan, A M ...... 1793 Arbuckle, T E ...... 1873* Avison, M J ...... 1755 Abdelmegeed, M A ...... 671 Allard, J ...... 548, 1075 Archer, J ...... 2115 Avram, M D ...... 111 Abdelrahim, M ...... 358* Allard, J L ...... 1004 Archer, T ...... 1861* Awasthi, Y C ...... 505 Abe, J ...... 654 Allayee, H ...... 1548 Archer, T k ...... 1860 Awe, S O ...... 306* Abe, K ...... 1642 Allen, D ...... 906* Archibong, A E ...... 2096, 2112* Awooda, I ...... 1383 Allen, D G ...... 907, 908, 909 Arcus, A ...... 883* Ayanoglu, E ...... 2337 Abedian, A ...... 2177 AUTHOR INDEX Abel, S ...... 756, 2295 Allen, J ...... 606*, 1229 Arezzo, J ...... 736* Ayehunie, S ...... 319, 396* Abel, S J ...... 1907 Allen-Hoffmann, B ...... 834, 1342 Arezzo, J C ...... 738* Aylward, L L ...... 1243 Aberdeen, G ...... 391 Allgeier, S H ...... 921* Arfsten, D P ...... 1056, 1241 Ayoub, J ...... 1673 Abernathy, C ...... 758* Alm, H ...... 368 Argentieri, D ...... 293 Azman, S ...... 1642 Abeyama, K ...... 1694 Almond, R ...... 2261 Argote, K ...... 1246* Abou-Donia, M B ...... 1447*, 1464 Alnouti, Y M ...... 1363* Arias-Salvatierra, D ...... 1776* Abou-Hadeed, A H ...... 575 Alston, S ...... 2060 Ariazi, E ...... 358 B Aboul Fadl, T ...... 1650 Alvarez Sanchez, R ...... 506 Ariizumi, M ...... 2263 Baan, R ...... 385 Aboyade-Cole, A ...... 1654 Alveres, C ...... 293 Arima, A ...... 130 Babiarz, J ...... 1997 Abraham, M H ...... 1312 Alvey, J D ...... 1737 Arimoto, R ...... 566 Babu, R ...... 177*, 1591 Abraham, W ...... 1024 Alvey, M ...... 1681, 1682 Arlt, V ...... 790* Babu, R J ...... 840 Abril, E R ...... 422 Alzarban, N ...... 1210 Armer, L ...... 1310* Babus, J ...... 391 Acar-Chiaradia, B ...... 1903 Amacher, D ...... 1684, 2016, 2017* Armstrong, C ...... 101 Babus, J K ...... 392, 448 Achanzar, W E ...... 2032 Amacher, D E ...... 630, 679, 1718 Armstrong, D ...... 2083 Baccam, M ...... 375*, 2265 Acheson, D ...... 2204* Amantana, A ...... 599* Armstrong, R ...... 541 Bachman, A N ...... 52*, 1226 Acosta-Saavedra, L C ...... 1776 Amato, C ...... 830* Arnold, L ...... 982 Backer, L ...... 584 Ada, A O ...... 697 Amato, C M ...... 837*, 841 Arnold, L L ...... 761, 975*, 1657 Backus, G S ...... 1067* Adachi, T ...... 2110 Amato, T ...... 1800 Arocena, M ...... 818, 819, 2087 Bacon, C W ...... 1993 Adachi, Y ...... 2140 Amberg, A ...... 522* Arreola-Mendoza, L ...... 2045* Baden, D ...... 584, 1024* Adair, B M ...... 2356* Amenuvor, L ...... 1601* Arrieta, D E ...... 785 Baden, D G ...... 552, 2438 Adam, A ...... 2051 Amin, K ...... 1962, 1963* Arrington, D ...... 461* Badger, T M ...... 1368, 1651, Adamou, A ...... 2092, 2360* Amuzie, C J ...... 999* Arroyo, C M ...... 1911 ...... 2401, 2403* Adeagbo, A S ...... 306 Anadon, A ...... 578*, 1489, 1821 Arshad, S ...... 2347 Badham, H ...... 980* Aden, J ...... 1182 Anagnostopoulos, A ...... 984 Arthaud, S ...... 1074, 2397 Badola, S ...... 2422 Adriaens, E ...... 1598* Anahara, R ...... 925*, 2100 Arthur, S R ...... 662 Bae, H ...... 1012* Aeby, P ...... 42*, 43, 1600 Anand, S S ...... 680, 1431*, Arthurton, J A ...... 1827, 1940 Bae, O ...... 415, 500*, 2054 Afriyie-Gyawu, E ...... 871 ...... 1803, 2304, 2365 Arts, J ...... 373, 1047* Baek, S ...... 1157 Afshari, C ...... 1534, 1662, 1967, 2150 Anantharam, V ...... 1766, 2008 Aruga, C ...... 492 Bagchi, D ...... 1420, 1681, 1682 Afshari, C A ...... 171, 172, 555 Ananthram, V ...... 2007 Arvidson, K B ...... 905* Bagchi, M ...... 1681, 1682 Afsharinejad, Z ...... 1472 Ancian, P ...... 1074*, 2397 Arzuaga, X ...... 91, 305* Bagi, C ...... 1944 Agarwal, R ...... 468 Andersen, M ...... 22, 1217, 1270 Asahi, S ...... 1094 Bagley, D ...... 45, 1596 Agmata, W ...... 2346 Andersen, M E ...... 26*, 597, Asakawa, A ...... 105* Bai, Y ...... 58 Ahaghotu, E ...... 840 ...... 839, 2125, 2310 Asamoto, M ...... 962 Bailey, G S ...... 1227 Ahern, L ...... 2249 Anderson, B ...... 160 Asanbe, O ...... 2418 Bailey, J P ...... 1013* Ahmad, A ...... 1673 Anderson, G D ...... 1570 Asano, S ...... 636*, 2166 Bailey, K A ...... 432* Ahmad, I ...... 1673 Anderson, J ...... 1753 Asaoka, Y ...... 120 Bailey, L ...... 2264 Ahmed, A E ...... 1735 Anderson, J G ...... 1755, 1763 Aschner, M ...... 4, 496, 498, 1110, Baillie, R ...... 2142 Ahn, K ...... 1518 Anderson, R ...... 158, 295 ...... 1755, 1756, 1763, Baillie, T A ...... 755* Ahn, M ...... 1076* Anderson, S ...... 568, 1121 ...... 1775*, 1780, 1785, Bain, L J ...... 444, 1563 Ahn, S ...... 605 Anderson, S E ...... 254* ...... 1786, 1842, 1844*, 2066 Baird, T J ...... 656 Ahr, H ...... 447 Anderson, T ...... 334 Asgharian, B ...... 2119* Baird, W M ...... 38, 55, 974, 1816 Ahr, H J ...... 2220* Andrade, A ...... 2085 Ashby, J ...... 953, 1222, 1931 Baja, E ...... 244* Aiba, S ...... 2283 Andreasen, E A ...... 222, 223* Ashikaga, T ...... 2279, 2280* Bajt, M ...... 1003* Aida, T ...... 2272* Andresen, C ...... 1944 Ashizawa, A ...... 1954 Baken, K ...... 1896* Aizawa, Y ...... 2442 Andresen, J ...... 1843 Ashley, A ...... 1097*, 2123 Baker, C ...... 234 Ajioka, M ...... 2272 Andrew, A ...... 421 Askins, L ...... 1924 Baker, D D ...... 1967* Akahori, F ...... 1378 Andrews, D L ...... 2258 Aslamkhan, A G ...... 451* Baker, G L ...... 803 Akgul, Y ...... 390*, 2102 Andrews, L ...... 175, 633 Asplund, C S ...... 2048 Baker, K ...... 1924 Akinbiyi, T A ...... 1069* Andreyev, S ...... 668 Assimon, S ...... 2001* Baker, T ...... 199 Akintobi, A ...... 833* Anekella, B ...... 1307* Astroff, A B ...... 594 Baker, T K ...... 289*, 1527 Alam, J ...... 1347 Anestis, D ...... 466 Astroff, B ...... 2332 Baker, V A ...... 2394 Albin, B C ...... 914 Angerer, J ...... 1252 Asuzu, I U ...... 1424* Bakke, J V ...... 878 Albores, A ...... 1814 Ankley, G ...... 2243 Atchison, D K ...... 1778, 2058* Bal, W ...... 1177, 1183 Albrecht, A ...... 2033 Ankley, G T ...... 1565 Atchison, W D ...... 1777, 1778, 1779, Balagopal, G ...... 913, 1269* Albrecht, E ...... 391 Anne, B ...... 251 ...... 2058, 2439 Balch, G C ...... 2246 Alcocer, M J ...... 2255 Ansari, G ...... 185, 287 Atherton, J ...... 2138 Baldetti, C ...... 1291 Alden, C ...... 757, 2222, 2422, 2423 Ansari, G A ...... 692, 2405 Atkin, J ...... 38 Baldwin, W S ...... 1327, 1563, 1830 Aldridge, J ...... 2321* Ansari, S G ...... 1720 Atkins, J L ...... 1382 Bale, A S ...... 2430* Aleksunes, L A ...... 1321 Antkiewicz, D S ...... 2160* Atsumi, R ...... 1621 Baleydier, A ...... 1317 Aleksunes, L M ...... 202,563,1001*, Antonini, J M ...... 1042, 1057*, Attia, M ...... 2104 Balhorn, R ...... 2353 ...... 1006, 1367, 2400 ...... 1058, 1059 Atzpodien, E A ...... 203 Ball, D J ...... 730* Alemdar, Y ...... 697 Antonio, S C ...... 1402 Au, C ...... 1763* Ball, G L ...... 886*, 1613 Alenius, H ...... 372 Antonios, D ...... 1143, 1734 Aubrecht, J ...... 560, 2216, 2217* Ball, L M ...... 808 Aleo, M ...... 620 Antoniou, E ...... 1404, 1405 Aud, D ...... 548 Ball, W ...... 115 Alex, L ...... 2051 Antony, V B ...... 1045 Augustine, L ...... 563 Ballatori, N ...... 941, 1161, 2067, 2131 Alexander, D ...... 346 Antrobus, K ...... 953 Augustine, L M ...... 1001, 1334, 2400 Balletta, L ...... 1616 up-to-date information at www.toxicology.org 257 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Ballinger, B ...... 620 ...... 2195*, 2305, 2341 Bhat, V S ...... 886, 1613* Boitano, S ...... 437* Ballinger, W E ...... 630 Beck, H ...... 42 Bhatia, S ...... 813* Boitier, E ...... 1223 Baltrukonis, D ...... 620 Beck, H J ...... 1588 Bhatnagar, A ...... 297, 306, 510 Boland, B ...... 490 Bammler, T ...... 966, 992, 1815 Beck, M ...... 2437 Bhattacharyya, A ...... 2400 Boldt, S ...... 2016* Bammler, T K ...... 234 Beck, M J ...... 935* Bhave, V S ...... 2145* Boldt, S E ...... 630, 679 Bandeen-Roche, K ...... 51 Becker, K ...... 142 Bhave, V ...... 2146 Bolger, M ...... 2194 Bandiera, S ...... 96 Becker, K G ...... 2418 Bhojraj, S ...... 1978 Bolger, P M ...... 2001, 2315* Bandiera, S M ...... 1806* Beckman, D ...... 141 Bhusari, S S ...... 1405* Bolmarcich, J ...... 44 Bando, T ...... 1694 Beckonert, O ...... 1859 Bibay, J ...... 553 Bolterstein, E A ...... 1994* Banerjee, A ...... 220 Bedard, L L ...... 542, 1649 Bigsby, R M ...... 1934 Bomann, W ...... 1528
AUTHOR INDEX AUTHOR Banerjee, T K ...... 1578 Bedford, M ...... 1330 Bigwarfe, T ...... 253 Bommu, P ...... 1985* Banfi, G ...... 698 Bedja, D ...... 2151 Bijaoui, E L ...... 1532* Bonati, L ...... 354, 356 Banks, C ...... 446, 650, 651, 661, Beerheide, W ...... 1712 Bildfell, R ...... 55 Bondy, G ...... 102 ...... 1292, 1308, 1695, 2092* Beezhold, D ...... 379 Biles, R W ...... 1467 Bondy, G S ...... 101* Bannon, D I ...... 1920* Begay, C K ...... 2078* Bility, M T ...... 965 Bone, H K ...... 248 Bao, W ...... 1920 Beger, R ...... 125, 2142 Bill, T ...... 1636 Bongiovanni, S ...... 141 Baohong, W ...... 1259 Beger, R D ...... 158, 164*, 200 Billack, B ...... 1687, 1913 Bonneh-Barkay, D ...... 1105 Baranowski, J ...... 1546 Begin, D ...... 916 Billam, M ...... 176* Bonner, A M ...... 646 Barbee, B D ...... 937 Behforouz, M ...... 2121 Billiard, S ...... 1876 Bonventre, J ...... 125 Barbee, R ...... 406, 1237 Behringer, S A ...... 1304 Billin, A N ...... 965 Bonventre, J V ...... 469, 1663, 1667 Barber, D S ...... 442, 1082, 1569, Behrsing, H ...... 1962*, 1963 Billings, R ...... 217* Bonzo, J A ...... 778* ...... 1800, 1801*, 2421 Bejati, S ...... 1334 Billups, L ...... 2187 Boobis, A ...... 2094 Barchowsky, A ...... 441, 1514*, 2047 Beland, F ...... 1685 Binkova, B ...... 1257 Boone, J S ...... 862 Barentsen, H ...... 1971 Belcher, L A ...... 2326 Binks, S P ...... 1283* Boone, L I ...... 628, 629 Barfknecht, T R ...... 815* Beli, E ...... 1990* Bion, A ...... 1187 Boor, P ...... 291 Barger, M ...... 479, 1046 Belikova, N A ...... 2002, 2003, 2004* Birch, A ...... 553 Boor, P J ...... 505 Barhoumi, R ...... 209, 358, 1383* Belinsky, S A ...... 438 Bird, H ...... 587 Boorman, G ...... 1000, 1148*, 1616 Barile, F A ...... 1972, 1973, 1974 Bell, D R ...... 98 Birindelli, S ...... 281, 282 Boorman, G A ...... 2132 Barker, D F ...... 21, 968, 1370* Bello, S M ...... 984* Birnbaum, L ...... 1169 Boos, J ...... 2026 Barker, P ...... 1846 Belski, T T ...... 70 Birnbaum, L S ...... 562, 596 Bopst, M ...... 203 Barker, S A ...... 1054 Beltran-Ramirez, O ...... 62* Biscocho, D ...... 1063 Borazjani, A ...... 694 Barlow, B M ...... 842 Bemis, J C ...... 212* Bishop, J ...... 1245, 2101 Borch, J ...... 1945, 2097 Barlow, S M ...... 1152* Ben-Jebria, A ...... 1135 Bissahoyo, A ...... 316 Borchers, C H ...... 973 Barnes, R ...... 620 Benadava, V ...... 1532 Bissonnette, A ...... 2423 Borg, K ...... 613 Barnes, S ...... 1006* Benbrahim-Tallaa, L ...... 430, 2037* Bissonnette, S ...... 1726 Borgert, C J ...... 1150* Barnewall, R E ...... 1921 Bendaly, J ...... 799* Biswal, S ...... 1348 Borghoff, S ...... 1270, 1272 Barone, S ...... 2302* Bender, J R ...... 294, 1855* Bizarro-Nevares, P ...... 2076 Borghoff, S J ...... 168 Barr, D B ...... 1237, 1516* Benedict, J ...... 382 Bizarro-Nevarez, P ...... 2075 Borlak, J ...... 224, 986, 1088, Barraj, L M ...... 2180, 2184 Benedict, J C ...... 929* Bjork, J A ...... 484, 2158 ...... 1346*, 1659 Barranco, W T ...... 1414* Benignus, V ...... 36, 2381 Blaauboer, B ...... 1971, 2377* Borm, P ...... 1193, 1853* Barrett, G ...... 2135 Benignus, V A ...... 2309 Black, A T ...... 831* Borneo, G ...... 547 Barrios, R ...... 1812 Benkovic, S A ...... 2417* Black, L E ...... 1740, 1741 Borowy-Borowski, H ...... 1160 Barron, A R ...... 826, 827 Benn, T M ...... 534 Black, W ...... 366, 1285 Borts, T ...... 198 Barros, S ...... 2422 Bennett, M B ...... 531 Blackard, B ...... 906 Borzelleca, J F ...... 763, 765* Barros, S B ...... 2084 Benninghoff, A D ...... 1338* Blackman, K ...... 1624 Bos, M ...... 48 Barrow, P C ...... 270 Benson, G ...... 1679 Blackshear, P E ...... 2132 Bosetti, C ...... 281 Barry, B E ...... 897* Benson, J ...... 584* Blaha, L ...... 66, 961* Bosetti, F ...... 2413 Bartels, M J ...... 463, 685, 1248 Benson, M P ...... 656, 2169* Blake, C L ...... 853* Bosland, M C ...... 276 Barton, H A ...... 590, 635, 1204, 2208 Benton, B ...... 80 Blake, L S ...... 1565 Bossart, G ...... 1581 Barve, S S ...... 1733 Benton, B J ...... 72, 77* Blake-Kinnin, M E ...... 563* Bosse, C ...... 1310 Barwick, J ...... 1341 Bentsman, G ...... 1757 Blakey, S ...... 903* Botta, D ...... 507*, 992 Basak, S ...... 915* Benz, F W ...... 642 Blancato, J N ...... 1276*, 2379, 2383 Bouchard, M ...... 861, 864, 870, 1604 Baskar, H ...... 2339 Benz, R ...... 905, 1133 Blanchard, J D ...... 734* Bouchard, R ...... 610 Basketter, D A ...... 376, 377*, 1145*, Bercegeay, M ...... 2416 Blanchard, K ...... 462, 1738 Bouchard DVM MS DACT, G F ... 1297 ...... 2273, 2275, 2277 Bercu, J P ...... 880* Blanchard, K L ...... 2* Boucher, G ...... 2016 Baskin, S I ...... 81, 1918, 1919 Berdasco, N ...... 387* Blanchard, K T ...... 1093 Bourdelais, A J ...... 552 Basnet, A ...... 247 Beresford, L ...... 2264* Blann, E ...... 205 Bourdi, M ...... 1010 Basova, L V ...... 2003, 2004 Berg, N ...... 375, 2265 Blazka, M ...... 45, 1596 Bourne, N ...... 1968, 1970 Bassett, B ...... 2091 Berger, J A ...... 232 Bleakman, D ...... 2416 Boutros, P C ...... 84 Bassett, D J ...... 1069 Bergman, A ...... 384, 1543 Bleckmann, C ...... 1723 Boverhof, D R ...... 82, 214, 221, Bassett, J ...... 1305* Berman, R F ...... 1452 Blennow, K ...... 2052 ...... 227*, 985 Bassingthwaighte, J B ...... 34* Bermudez, E ...... 184* Blessing, H ...... 1183 Bowen, M E ...... 425 Basun, H ...... 2052 Bermudez, M ...... 1331 Blessing, J C ...... 1661 Bowen, N ...... 2394 Batchinsky, A I ...... 478 Bermudez de Leon, M ...... 1814 Bloemeke, B ...... 211* Bowers, T S ...... 875*, 2181 Bateman, B ...... 366 Berndt, L ...... 1961* Bloemen, H ...... 1198 Bowler, R ...... 188 Batista, A C ...... 1262 Bernsetin, S H ...... 1653 Blomme, E ...... 756, 1546* Bowman, C C ...... 2252* Baudrimont, I ...... 1387 Bernstein, D I ...... 1498* Blomme, E A ...... 1708, 1711, Bowman, L ...... 1019 Bauer, D ...... 1564 Berridge, B ...... 198, 290 ...... 1819, 1905, 1907 Bowyer, J F ...... 2419* Bauer, L ...... 1496 Berthiaume, J ...... 484, 2158 Blonder, J M ...... 1688* Boyd, W ...... 40* Baumel, I ...... 1636 Berthiaume, J M ...... 1083* Blondina, G ...... 2313 Boyd, W A ...... 1178, 2036 Baumler, W ...... 822 Besselsen, D G ...... 2400 Bloom, S ...... 1728 Boyer, J ...... 617, 998, 1664 Baye, J ...... 1296, 1298, 1617 Bessems, J ...... 1902, 2381* Bloom, S E ...... 1727* Boyer, M ...... 446* Bayir, H ...... 1163, 2003, 2005* Bessinger, B A ...... 2188 Bloomer, S ...... 201 Boyer, S C ...... 1282, 1904* Baynes, R E ...... 812, 842*, 843 Best, D ...... 1946 Blossom, S ...... 1901 Boyes, W K ...... 1268, 2309, Bayse, G S ...... 674* Betancourt, A M ...... 1443*, 1471 Blum, J L ...... 1935* ...... 2416*, 2430 Baze, W ...... 606 Betat, A ...... 1317 Blumenthal, G ...... 2312 Boykin, E ...... 236, 249 Bazzi, R M ...... 98 Betts, C J ...... 2259*, 2264, 2273 Bobeldijk, I ...... 930 Boykin, E H ...... 374, 2258* Beall, H ...... 2121 Betz, L ...... 1671 Bobowski, C ...... 225* Boyles, R ...... 1199* Beall, H D ...... 363, 423 Beushausen, S ...... 1668, 1859 Bobseine, K ...... 1168 Boysen, G ...... 187, 973* Beall, P A ...... 2070 Bevan, R ...... 2083 Boeckman, H ...... 1036 Bracher, M ...... 1600 Beard, D J ...... 657, 658* Beyer, D ...... 1247 Boeckman, H J ...... 1056*, 1241 Bradford, B ...... 1616 Beard, K ...... 1288* Beyer, J ...... 2 Boekelheide, K ...... 2098 Bradford, B U ...... 194 Beasley, H ...... 818, 819 Beyer, L A ...... 2305* Boelsterli, U A ...... 1712, 2136 Bradshaw, B D ...... 1625 Beaton, D ...... 1323, 1807 Beyer, R ...... 966, 992 Boere, J ...... 1193, 1198 Brady, L ...... 182, 1907, 2392 Beaubier, J ...... 969 Beyer, R P ...... 234 Boess, F ...... 203*, 506 Brady, S ...... 2153* Beaulieu, A ...... 2391* Bezdecny, S ...... 97* Bogen, K ...... 1865 Brain, J ...... 1751 Beaumont, J ...... 899 Bhalla, D K ...... 1069, 1070, Bogen, K T ...... 1867* Brain, K ...... 813 Becaria, A ...... 246 ...... 1134*, 1137* Bogue, M ...... 1616 Brambila, E M ...... 2032* Bechtel, D H ...... 1981* Bhandari, N ...... 2133* Bohonowych, J E ...... 353 Brand, R ...... 816* Beck, B D ...... 759*, 875, 2186, Bhaskaran, V M ...... 1710 Boisleve, F ...... 1143 Brandt, I ...... 384
258 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Branham, W S ...... 1717 Bucher, J ...... 80, 2094 Cai, Q ...... 176, 1795* ...... 1851*, 1852, 1853 Brant, K A ...... 1553* Bucher, J R ...... 1537, 1538 Cai, W ...... 2121 Carter, L ...... 1302 Brasel, J M ...... 1576* Buchmann, E ...... 1113 Cain, A V ...... 1264, 1265*, Carter, M ...... 2161 Bratton, S B ...... 341, 344*, 2122 Buchweitz, J ...... 1041* ...... 1266, 1267 Carter, M M ...... 127* Braue, C R ...... 1917 Bucio, L ...... 2035 Cain, W S ...... 1312, 2340* Carter, Jr., W ...... 1627 Braun, K ...... 522 Buckalew, A ...... 1166, 1946, 1948 Calabrese, E ...... 1865 Carvan, M J ...... 394, 1119* Braun-Sommargren, M ...... 1764* Buckley, B ...... 952, 1484, 1781 Calabrese, E J ...... 1866* Casati, S ...... 1968, 1970 Bray, J J ...... 1925 Buckley, D B ...... 1361* Calabro, A R ...... 1974* Casavant, R H ...... 1036* Braydich-Stolle, L K ...... 37* Buckpitt, A ...... 490 Calafat, A M ...... 2113 Casbohm, S ...... 1921* Breckenridge, C ...... 49, 50* Buckpitt, A R ...... 1026 Calderon, L G ...... 363 Casciano, D A ...... 321* Bredeweg, E ...... 1585 Budinsky, R ...... 1631 Calderon, R ...... 762* Case, L ...... 245 Bredfeldt, T G ...... 424*, 425, 427 Budinsky, R A ...... 1243 Calderon-Aranda, E S ...... 1776 Casey, W ...... 198 Bredow, S ...... 438, 1182* Buelke-Sam, J ...... 653, 935 Caldwell, J ...... 2083 Casillas, R ...... 1923 Breen, M S ...... 2118* Buelow, L ...... 1357* Caldwell, R ...... 1743* Casola, A ...... 1373 Brees, D J ...... 613 Buenger, D A ...... 628, 629 Calgaro-Helena, A F ...... 1402 Caspary, W ...... 546 Brennan, R ...... 784, 987, 1889 Buermeyer, A B ...... 514 Calkins, M ...... 2415* Cassee, F ...... 1193, 1198* Brennan, R J ...... 2216*, 2219*, 2337 Buesen, R ...... 142 Callegari, E ...... 613 Cassell, M ...... 984 Breyer, R M ...... 498 Buffington, J A ...... 1759* Callio, J ...... 511 Cassidy, K ...... 621, 622 Brezinski, M ...... 1092 Buffler, P ...... 1874* Callis, C M ...... 880 Castaigne, J ...... 624, 626, 942 Bricarello, A ...... 844 Bugelski, P ...... 2241* Calvin, J ...... 987 Castillo, D ...... 2085 Bridges, T ...... 1639 Bugge, M E ...... 1572, 1573, 1942 Camacho, A ...... 1303 Castillo, N P ...... 1242 Brien, J F ...... 643, 644 Bugrim, A ...... 668 Camacho, H ...... 178* Casto, B C ...... 1648 Brightsmith, D ...... 1577 Buhler, D R ...... 1816, 1834 Camacho, S ...... 110 Castorena-Torres, F ...... 1814* Brimecombe, J ...... 663, 665* Bui, P H ...... 1835* Cameron, D G ...... 478 Castranova, V ...... 479, 846, 1019, Brimfield, A A ...... 821, 1911*, 1912 Bui, Q Q ...... 1980* Cammer, S ...... 80 ...... 1046, 1556, 1557 AUTHOR INDEX Brine, D ...... 568 Buitenhuis, C ...... 384* Campbell, A ...... 246* Castro, S ...... 1373*, 2202 Briner, K ...... 622 Bulk, S ...... 1212 Campbell, A R ...... 2111, 2369* Catalani, A ...... 1454 Britt, J K ...... 866*, 2192 Bulku, E ...... 1979 Campbell, H ...... 1695* Cate, M L ...... 599 Broadwin, R ...... 901 Bullman, S ...... 1447 Campbell, J ...... 988 Cater, K ...... 1599* Broadwin, R L ...... 882 Bultman, J ...... 649 Campbell, J L ...... 2386* Catlin, M ...... 2205 Broccardo, C J ...... 2398* Bumbgarner, R ...... 1647 Campbell, K ...... 1787 Catlin, M ...... 2207* Brochu, P ...... 117* Bumgardner, S A ...... 1294 Campbell, M ...... 899 Catricks, N ...... 253 Brocker, C ...... 489 Bunge, A L ...... 814 Campen, M J ...... 76* Caudle, M ...... 2441* Brodberg, R ...... 1602 Burback, B ...... 2352 Campian, J ...... 503 Cauntay, P ...... 993 Brodberg, R K ...... 2313 Burback, B L ...... 2363* Campo, L ...... 281 Caya, N ...... 649 Broderick, D ...... 2027 Burcham, P C ...... 1192* Cancio, L C ...... 478 Ceballos, D ...... 234 Brodeur, J ...... 117 Burchiel, S W ...... 264* Candelas, J ...... 280 Cebrian, M E ..... 428, 863, 1184, 1822 Brodie, S ...... 2432 Burdick, A D ...... 965* Canerdy, T ...... 1681, 1682 Centeno, J ...... 2071 Brodmerkel, C M ...... 1740 Burdock, G A ...... 1156* Cannon, C ...... 396 Cerreta, J M ...... 806, 1038, 2014 Brodsky, B ...... 1910 Burel, S ...... 993* Cannon, J R ...... 1103* Cerven, D R ...... 2274, 2278 Brokken, L ...... 1945 Burgaz, S ...... 697 Cano, M ...... 761, 975, 982, Chacko, M S ...... 174 Broman, K W ...... 796 Burgess, J ...... 166 ...... 1657, 2089, 2275 Chacon, E ...... 1302 Bromberg, P ...... 1513 Burgess, S ...... 1825 Cantor, G H ...... 161, 1710, 2228 Chakravarty, K ...... 548 Bromberg, P A ...... 640 Burghardt, R ...... 209, 358 Cantor, J O ...... 806, 1038 Chambers, H ...... 1476 Bronaugh, R L ...... 810 Burghardt, R C ...... 1383 Cantor, R ...... 1548 Chambers, H W ...... 695 Brooks, A ...... 1149*, 2350 Burgher, F ...... 1587* Cao, C ...... 1968, 1970 Chambers, J ...... 1825, 2374 Brooks, B ...... 2243 Burgoon, L ...... 782, 1336 Cao, D ...... 639* Chambers, J E ...... 695, 862, Brooks, B W ...... 1583, 2247* Burgoon, L D ...... 82, 221, 227, Cao, Y ...... 1209 ...... 1444, 1445, 2209 Brooks, D M ...... 363 ...... 398, 403, 985, Cao, Z ...... 2438 Chambliss, C K ...... 1583 Brooks, E ...... 38, 55, 1816 ...... 990*, 996, 1337, 1340 Capacio, B ...... 2350 Chan, C Y ...... 538*, 2314* Brooks, E G ...... 2251 Burka, L T ...... 100, 1029, 1831, 1878 Capen, C C ...... 7 Chan, D ...... 110*, 729 Brooks, J ...... 359* Burkart, D L ...... 984 Capili, A ...... 78 Chan, G ...... 1687* Brooks, J D ...... 812 Burnett, D ...... 80 Car, B D ...... 662, 1710, 2147, Chan, K ...... 689 Broschard, T H ...... 598*, 604 Burnett, E ...... 662 ...... 2227, 2228* Chan, P ...... 1422, 1820, 1831 Brott, D ...... 1857, 2168 Burns, A M ...... 194 Carabin, I ...... 767* Chan, S ...... 1564 Brouwer, A ...... 384 Burns, C ...... 1871, 2172 Carabin, I G ...... 763 Chan, V ...... 170* Brown, A ...... 655 Burns, C J ...... 1874 Caravanos, J ...... 2059 Chan, W K ...... 1343 Brown, A M ...... 659, 663, 666 Burns, K A ...... 197* Caraway, C A ...... 883, 1927 Chanda, S ...... 1075 Brown, C E ...... 2162 Burns, T D ...... 1992* Carbone, D ...... 494 Chanderbahn, R ...... 911 Brown, D J ...... 1263 Burns Naas, L ...... 323*, 2249* Carbone, D L ...... 1102* Chandra, D ...... 343 Brown, J ...... 849, 1791 Bursian, S ...... 1567 Cardoza, K ...... 2423 Chandrasekar, M ...... 1985 Brown, J P ...... 2185* Burt, J ...... 782*, 1336 Carey, S A ...... 1066* Chaney, J G ...... 2277 Brown, J S ...... 900* Burt, J W ...... 398 Carfagna, M A ...... 628, 629* Chaney, S ...... 1790 Brown, K G ...... 2183* Burton, N C ...... 502* Cariello, N ...... 1089 Chang, B ...... 1564 Brown, L A ...... 1436* Bus, J S ...... 685, 1871* Carlisle, J ...... 729, 2191* Chang, C ...... 61, 67 Brown, N M ...... 213 Buse, E ...... 2167 Carll, A P ...... 2173* Chang, L ...... 436* Brown, P J ...... 542* Bushman, W ...... 128 Carlsen, K H ...... 878 Chang, L W ...... 954 Brown, R ...... 125, 268, 1089, Bushnell, P J ...... 2309*, 2430, 2431 Carlson, C ...... 2200* Chang, S ...... 1017* ...... 1750, 2339* Butala, J H ...... 873, 2340 Carlson, R M ...... 2342 Chang, W ...... 1733* Brown, R P ...... 1667 Butenhoff, J ...... 573, 603, Carlson-Lynch, H ...... 382 Chang, X ...... 215, 218* Brown, S ...... 466, 1907 ...... 1234*, 2327, 2385 Carlton, B ...... 1240* Chang, Y ...... 954, 1915 Brown, S C ...... 1045* Butenhoff, J L ...... 576 Carmical, J R ...... 2355 Chanock, S ...... 526 Brown, T ...... 1442 Butterworth, E ...... 34 Carnes, A R ...... 449 Chapin, R E ...... 2101 Brown DVM, Ph.D, L ...... 1297 Byard, S J ...... 2394 Carnes, K ...... 1548 Chapman, L M ...... 1327*, 1830 Bruckner, J V ...... 572, 680, Byrd, D M ...... 869 Carney, E ...... 1627, 2323 Chapman, R ...... 1555 ...... 1431, 1803, 2365 Carney, E W ...... 1243 Chappell, A S ...... 740* Bruene, B ...... 471 Carney, S A ...... 2172* Charbonneau, M ...... 960 Bruening, T ...... 1252 C Carosino, C M ...... 583 Charles, J ...... 1969* Bruff, T C ...... 2340 Caballero, V ...... 578, 1489, 1821 Carpin, J C ...... 1031, 1032, 1034* Charlwood, J K ...... 512 Bruner, R H ...... 2322 Cabonce, M ...... 1668 Carr, G ...... 402 Charron, A R ...... 816 Brunnberg, S ...... 88 Cadby, P A ...... 2275 Carr, G J ...... 1551 Chassot, L ...... 42 Bruno, M E ...... 1081 Cadet, J L ...... 2418 Carr, R ...... 1476 Chatterjee, A ...... 177, 1591 Bruno, R ...... 2141 Cady, B ...... 1585 Carr, R L ...... 1443, 1444, 1445, 1471* Chatterjee, I ...... 1578 Bruun, D ...... 1441 Caffmeyer, J ...... 1285 Carr, T ...... 1546 Chaudhary, A ...... 1246 Bryant, S ...... 789 Caguyong, M J ...... 201, 1692 Carrao, A M ...... 1625 Chaudhary, A M ...... 63* Brynczka, C ...... 1104* Cahill, P ...... 1582 Carrier, G ...... 861, 864, 870, 1604 Chaurand, F ...... 582, 1301 Brys, A ...... 180* Cahill, T M ...... 1705 Carrier, R ...... 1609* Cheetham, C ...... 94 Brys, A M ...... 1090 Cai, J ...... 162, 642, 1110 Carrington, C D ...... 2194*, 2315 Cheever, K L ...... 2354* Bu, P ...... 342, 2009* Cai, L ...... 2156 Carroll, R E ...... 1645 Chekarova, I ...... 874, 927 Bucci, P ...... 2437 Cai, P ...... 287*, 1163, 2405 Carter, J ...... 1466, 1850, Chen, B ...... 1057 up-to-date information at www.toxicology.org 259 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Chen, C ...... 1349, 2383 Chuang, C ...... 1185 Cometto-Muniz, J E ...... 1312* Crean, C ...... 617 Chen, G ...... 1021, 2017 Chun, H ...... 1400 Conde-Moo, P C ...... 1776 Creasy, D M ...... 2331 Chen, H ...... 1548, 2068* Chung, H ...... 2064 Condevaux, F ...... 271, 1742* Creech, A C ...... 100 Chen, J ...... 2172 Chung, J ...... 401, 415*, 500, Conklin, D J ...... 297, 306, 510* Creech, D ...... 1089 Chen, J J ...... 554 ...... 704*, 1884*, 2054, 2362 Connor, A ...... 481* Creek, M R ...... 49, 50 Chen, L ...... 100, 244, 1195, Chung, S ...... 500, 2054 Conolly, R ...... 1875*, 2116, 2124* Creppy, E E ...... 1387*, 1388* ...... 1196, 1197*, 1878 Chung, Y ...... 371, 1400*, 1407, Conolly, R B ...... 1885, 2118, 2310 Crews, F T ...... 162 Chen, L C ...... 1706* ...... 1410, 1411, 1412, Consenza, M ...... 1675 Crincoli, C M ...... 2408, 2409* Chen, M ...... 1178, 1846 ...... 2064, 2257* Constable, J D ...... 90 Crissman, J ...... 1240, 2328 Chen, P ...... 1673 Chung, Y H ...... 1752 Contrera, J F ...... 1133 Crissman, K ...... 1063
AUTHOR INDEX AUTHOR Chen, Q ...... 1211, 1660, 1790 Chvatalova, I ...... 1257 Cook, D ...... 2161* Cristiano, N ...... 1739 Chen, Q M ...... 346* Ciencewicki, J M ...... 1200* Cook, D L ...... 438, 971 Criswell, K ...... 334 Chen, R ...... 869 Cinque, C ...... 1454 Cook, J C ...... 7 Crittenden, P L ...... 1758* Chen, S ...... 778, 1323*, 1807 Cisneros, B ...... 1814 Cook, J D ...... 700 Crockett, P ...... 1970 Chen, T ...... 958* Cisneros, F J ...... 2129* Cook, N ...... 537* Crofoot, S ...... 589, 1240, 2328 Chen, T S ...... 1733 Cisneros-Vega, B ...... 1331 Cook, T J ...... 362*, 919 Crofoot, S D ...... 811, 1929, 1940 Chen, X ...... 345 Ciurlionis, R ...... 1546 Cooke, E ...... 213 Crofton, K ...... 1425 Chen, Y ...... 54, 501*, 504, Cizmas, L ...... 525, 1250 Cooney, D ...... 1703* Crofton, K M ...... 405, 1203, ...... 539, 1110*, 1220, Clark, A P ...... 594 Coonse, K G ...... 2015* ...... 1428, 1483 ...... 1390, 1677*, 2139 Clark, C ...... 2350 Coonts, A J ...... 2015 Crome, S ...... 1286 Cheng, L ...... 1124 Clark, G ...... 865 Cooper, J F ...... 1796* Cromey, D ...... 425 Cheng, O ...... 1692 Clark, G C ...... 1263*, 1930 Cooper, K ...... 1141*, 1679 Crooke, R M ...... 292, 308 Cheng, T ...... 436 Clark, M L ...... 1661 Cooper, K L ...... 434* Crooks, D ...... 1764 Cheng, X ...... 564*, 1361 Clark, N ...... 975, 1657 Cooper, K R ...... 151, 1484, 1571 Crooks, D R ...... 2062* Chengelis, C P ...... 2165 Clark, O E ...... 1914* Cooper, P S ...... 1* Crosby, L M ...... 157* Cheong, K A ...... 1690 Clark, R ...... 2005 Cooper, R ...... 1166, 1932, Crosier, R B ...... 72, 1925 Cherr, G ...... 934 Clarke, E ...... 1688, 1964 ...... 1946, 2055 Crossgrove, J S ...... 1771* Cherrington, N ...... 1209 Clarke, J ...... 132, 252, 608 Cooper, R L ...... 389, 1948* Crouse, C L ...... 80 Cherrington, N J ...... 563, 1001, Clarke, J B ...... 634 Cooper, S ...... 568 Crow, J A ...... 695* ...... 1334, 2400 Clarkson, E ...... 1924 Cooper, S M ...... 459*, 1829 Crowell, J ...... 1677 Chetty, C S ...... 1787* Clarkson, E D ...... 81* Cope, R ...... 1656* Crowell, J A ...... 1674, 1676, Chevalier, S ...... 1859 Clarkson, R ...... 585 Copeland, C ...... 1897 ...... 1982, 1983, 2088* Chhabra, R ...... 2321 Clarkson, R J ...... 583 Copeland, C B ...... 255 Crump, K ...... 894 Chi, R P ...... 278 Clayton, N P ...... 1831* Copeland, L ...... 2257 Crump, K S ...... 2124, 2182 Chiba, M ...... 2043 Clegg, E ...... 1121 Copeland, L B ...... 371 Cruz, E ...... 2141 Chibout, S ...... 141, 788 Clemo, F ...... 298, 1859 Copeman, C ...... 1288, 1289, Csanaky, I ...... 439 Chilakapati, J ...... 452, 688*, 1008 Clewell, H J ...... 1271, 1280, 1885, ...... 1290, 1310 Csizmadia, E ...... 2423 Chintharlapalli, S ...... 1157*, 1324 ...... 1886*, 2124, 2182, 2310 Coppin, J ...... 430*, 2037 Csizmadia, V ...... 2422*, 2423 Chiodi, V ...... 1454 Clewell, R A ...... 1270*, 1279 Copple, B ...... 1366* Cuda, M E ...... 511* Chiorazzi, N ...... 1653 Clifford, C C ...... 165 Corbell, J ...... 162 Cuff, C ...... 1990 Chipman, J ...... 2083 Clothier, R ...... 1968, 1970 Corcoran, G ...... 1504* Cuff, C F ...... 261, 999 Chipman, J K ...... 2399 Coady, L ...... 101, 102 Cordier, A ...... 141, 788 Cui, H ...... 687 Chisato, M ...... 140 Coban, A ...... 1476, 1486, 1487 Cordova, E ...... 428 Cui, Y ...... 2036* Chiu, A ...... 913 Cobb, M H ...... 1510* Corley, R ...... 9 Cumberbatch, M ...... 376, 2260, 2261* Chiu, A o ...... 969* Cobbett, P J ...... 2058 Corley, R A ...... 35*, 463, 583, Cumine, S ...... 1105 Chiu, N H ...... 969 Coburn, C G ...... 94* ...... 585, 1526 Cummings, B S ...... 12*, 14*, 470, 499 Chiu, W A ...... 2383 Cocaj, A ...... 2178 Corley-Smith, G E ...... 1816*, 1834 Cumpston, J ...... 1057 Cho, A ...... 535 Cochelin, O ...... 1532 Cornelius, G ...... 662 Cundiff, J A ...... 258, 277 Cho, D ...... 401, 450 Cockman, C ...... 1876 Cornwell, P D ...... 1692* Cunnick, J ...... 272 Cho, J ...... 273*, 791, 2268 Cockshott, A ...... 771*, 2273* Correia, L ...... 1684 Cunningham, J R ...... 1241 Cho, M ...... 1017, 1018, 1049, Coen, M ...... 161* Corsini, E ...... 281*, 282 Cunningham, M ...... 27, 30*, 1000 ...... 2013, 2053, 2334 Coffee, M ...... 2176 Corton, C ...... 1504 Cunningham, M L ...... 194, 1878 Cho, Y ...... 1410*, 1996 Coffey, T ...... 884* Corton, J C ...... 1503* Cunningham, V L ...... 1283 Choi, B ...... 1773* Coffin, J ...... 363* Cory-Slechta, D ...... 336* Curran, C P ...... 87*, 931, 1810 Choi, C ...... 1371*, 1719 Coffin, J D ...... 423 Cory-Slechta, D A ...... 335, 831, 1108, Curran, I ...... 101, 102* Choi, C J ...... 1766* Cogliano, V J ...... 385* ...... 1188, 1488, 1802, 2436 Curras-Collazo, M C ...... 94 Choi, E ...... 1938, 1958*, 2420 Cohen, D ...... 2063* Coryell, V H ...... 2048, 2073 Curren, R D ...... 44, 559*, Choi, J ...... 1409, 1411, 1412, 2334 Cohen, J ...... 1160, 2312 Cosenza, M ...... 555, 1534, 1683, 1967 ...... 912, 1595 Choi, J H ...... 86* Cohen, S ...... 982, 2089, 2094 Cosma, G N ...... 1905 Currie, R ...... 1222*, 1931, 2259 Choi, M ...... 1049 Cohen, S D ...... 761* Costa, D L ...... 705, 1698, 2173 Currie, R A ...... 953 Choi, O M ...... 1690 Cohen, S M ...... 975, 1657 Costa, L ...... 1454, 1472, 2006 Currier, N ...... 670 Choi, S J ...... 1752 Cohn, P ...... 1608 Costa, L G ...... 1437, 1438, 1446 Curti, C ...... 1402 Choi, W ...... 1109 Cojocel, C ...... 515* Costa, M ...... 2068 Curtin, G M ...... 52 Choi, W H ...... 1690 Colbourne, J K ...... 1564 Coston, T ...... 818, 819 Curtis, A ...... 1724 Choksi, N ...... 906 Cole, E E ...... 1658 Cote, I ...... 1635 Curtis, L R ...... 1325 Choksi, N Y ...... 907*, 908, 909 Cole, P A ...... 1011* Cottrell, L ...... 1222 Curtsinger, A ...... 1681, 1682 Choo, E ...... 844 Cole, T B ...... 1446* Coudouel, H ...... 1587 Cushing, C A ...... 2190* Chou, C ...... 1999* Coleman, J D ...... 196* Coughlan, S ...... 1178 Custance, S R ...... 1610 Chou, D ...... 2028* Coleman, P ...... 1636, 1926 Coulombe, R A ...... 237, 1832*, 1991 Cutler, N ...... 242 Chou, I ...... 641, 1365, 2028 Coleman, S ...... 2422, 2423 Coulson, M ...... 1533 Cutler, N S ...... 1881 Chou, J ...... 1000, 1093 Coleman, T ...... 36* Couroucli, X ...... 1812* Cyr, D ...... 960 Chou, S ...... 892, 915 Coli-Barenque, L ...... 2075 Couroucli, X I ...... 1811 Cyr, M O ...... 1130 Chou, Y ...... 93 Colin-Barenque, L ...... 2061, 2076 Courson, D ...... 1036 Czerwinski, S E ...... 1919* Choudhury, E A ...... 2347* Collaco, C ...... 2251 Court, M H ...... 1004 Czich, A ...... 522 Choudhury, H ...... 918*, 2289 Colleton, C A ...... 2321 Courter, L A ...... 55* Chouinard, L ...... 2092 Collette, W W ...... 159, 1314* Couture, J ...... 2388, 2389, 2390, 2391 Chowdhury, U K ...... 111 Collins, B ...... 568 Covell, D ...... 991 D Choy, G ...... 343 Collins, J ...... 205 Cover, C ...... 1003 D’Agostino, J ...... 1833 Christensen, A ...... 131, 1980 Collins, J F ...... 2185 Covington, T R ...... 1280* D’Altilio, M ...... 1681, 1682* Christian, M ...... 133* Collins, J J ...... 1235 Cowden, J ...... 138, 148* D’Ambrosio, A ...... 2350 Christian, M M ...... 938 Collins, M ...... 1548 Cowlen, M S ...... 617* D’Angona, A ...... 175 Christian, M S ...... 933 Collins, S ...... 58 Cozzetta, J ...... 146 D’Souza, S E ...... 297*, 306 Christiansen, K ...... 1908 Collins, T ...... 721* Cozzi, N ...... 1296, 1298 Daamen, F E ...... 1951 Christie, M A ...... 2144* Collison, K ...... 947 Craft, E S ...... 1375* Dabisch, P ...... 74, 75, 1033, 1034 Chu, A C ...... 1263, 1930 Colman, J ...... 918 Craig, A ...... 1406 Dabisch, P A ...... 72, 73*, 77, Chu, C ...... 511 Colosio, C ...... 281, 282 Craig, D K ...... 2316* ...... 1031, 1032 Chu, H ...... 638 Colton, H ...... 1089 Craigmill, A R ...... 2369 Dabrowski, M ...... 992 Chu, M ...... 381 Colvin, V L ...... 823, 825, 829, 1554 Crane, D ...... 2313 Daggett, D A ...... 1625* Chu, M D ...... 1263, 1930 Comeau, J L ...... 643* Cranmer, B ...... 597, 1217, 2370 Dagues, N ...... 1859 Chu, T ...... 1920 Comereski, C ...... 245 Crasta, O ...... 80 Dahlin, S ...... 214*
260 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Dahly-Vernon, A ...... 1296, 1298 DeAngelo, A B ...... 157 Devlin, R B ...... 645 ...... 646, 1294, 2125 Dai, Q ...... 1893* Dearman, R ...... 377, 378 DeVona, D ...... 253 Dorta, D ...... 1402* Dai, X ...... 201, 1692 Dearman, R J ...... 376, 1841*, 2254, DeVoney, D ...... 983*, 2311 Doshna, C ...... 620 Dail, M ...... 1825* ...... 2255*, 2259, 2260, Dewey, L ...... 659 Dotson, G ...... 853 Dailey, L A ...... 645 ...... 2261, 2264, 2273, 2277 DeWitt, D S ...... 495 Dougherty, E J ...... 775* Dako, S ...... 544 Debia, M ...... 916* DeWitt, J ...... 1897* Douglas, A ...... 1924 Dalbey, W ...... 129* DeBoef, J M ...... 623* DeWitt, J C ...... 255 Douglas, G ...... 181 Dale, Y R ...... 216* Decamp, E ...... 1845 DeWoskin, R S ...... 32, 33*, 2378 Douglas, G R ...... 1961 Dalgaard, M ...... 1945, 2097* DeCaprio, A P ...... 2427* Dey, S ...... 491 Doull, J ...... 2209* Dalgleish, H A ...... 403* Dechkovskaia, A ...... 1447 Deyrup, C ...... 2000 Dourson, M ...... 2286 Dalton, J A ...... 2169 Deck, T ...... 2352 Di Giulio, R ...... 1876* Dourson, M L ...... 917, 1640, 2297 Dalton, T P ...... 87, 501, 504, DeCristofaro, M ...... 788 Di Monte, D A ...... 1098, 1105, Dow, J ...... 1222 ...... 931, 1809, 1810, DeCristofaro, M F ...... 141* ...... 1107, 1112 Dowling, K C ...... 2191 ...... 1877, 2024, 2029, 2030 Deese, A ...... 159, 1314 Dial, S ...... 205, 2142 Doyle, M ...... 1060, 1065*, Dalvi, R ...... 2187 DeFrank, N M ...... 1641 Diamantakos, E ...... 449*, 1663, 2022 ...... 1702, 2214 Damen, J ...... 1688, 1964 Degaonkar, M ...... 1846 Diamond, G L ...... 858, 1274, 2373 Dragan, Y ...... 205, 2142 Damian, S ...... 1966 DeGeorge, G L ...... 558, 820*, Diawara, M M ...... 146, 939* Dragan, Y P ...... 2395 Damodaran, T V ...... 1464* ...... 2274, 2278* Diaz, D ...... 1306* Dragin, N ...... 1810*, 1877 Damore, M ...... 171, 2150 Degitz, S ...... 1941 Diaz, E ...... 2211 Drake, V ...... 144 Dandekar, D ...... 1528* Degitz, S J ...... 1572, 1573, 1942 Diaz, M J ...... 578, 1489, 1821 Drake, V J ...... 143* Dandona, P ...... 1505* Deglin, S E ...... 814* Diaz-Bech, P ...... 2061 Drechsel, D ...... 1101* Dangott, L J ...... 1322 Dehart, D B ...... 139 Diaz-Sanchez, D ...... 780 Dreptate, D ...... 1532 Danielewska-Nikiel, B ...... 2346 Dekant, W ...... 506, 598, 604, 963 DiCicco-Bloom, E ...... 1783 Driscoll, K ...... 1850* Daniels, K K ...... 1073 Dekkers, S ...... 896*, 1902 Dickey, R W ...... 1429 Driver, J H ...... 1261 Daniels, M ...... 236, 249 DeKosky, S ...... 2005 Diener, R M ...... 933, 938 Drobna, Z ...... 426, 440, 443* AUTHOR INDEX Daniels, M J ...... 2258 DeKrey, G ...... 259, 1828 Dieter, M Z ...... 2147 Du, F ...... 1767 Danilenko, D M ...... 615 Dekura, E ...... 492 Dieterle, F ...... 788* Du, X ...... 2028 Danilo, C ...... 1958 Del Pino, J ...... 1489, 1821 Dietrich, D R ...... 447, 471, Duan, J ...... 616 Dannan, G ...... 2295 Del Razo, L M ...... 428, 1256, ...... 472, 473, 474, Duan, S X ...... 1004 Dannappel, D ...... 698 ...... 1769, 1798, 2045 ...... 475*, 476, 477 Duarte, S J ...... 280 Dano, S D ...... 1387, 1388 del Rio Garcia, C ...... 863 Dietsch, G ...... 169 Dubick, M A ...... 478* Danthi, S J ...... 659 Del Sindaco, Y ...... 1532 Dijkstra, A ...... 930 Dubois, J M ...... 1007 Darbre, P ...... 1153* del Soldato, P ...... 2136 Diliberto, J J ...... 562*, 596 Ducharme, D ...... 426 Darche, J ...... 1532 Delcarpini, J ...... 633 Dillman, J F ...... 1355, 1917, 1920 Duckworth, B ...... 1859 Darling-Reed, S F ...... 2114 Delclos, K B ...... 459, 1829 Dills, R L ...... 229 Ducre-Robitaille, J ...... 117 Dary, C C ...... 1219, 1276 Delgado, V ...... 2061, 2075 Dimitrov, D ...... 2120* Duddy, S ...... 298 Das, A K ...... 2288 Delker, D ...... 53, 54*, 1229 Dimitrov, D S ...... 991 Dudkowski, C ...... 1673 Das, D K ...... 1382 Dellarco, V ...... 1147* Dimond, S S ...... 944*, 1242 Dueker, S R ...... 2384 Das, K ...... 576, 937 DeLong, B ...... 1026 Din, L B ...... 1165 Duester, G ...... 366 Das, K P ...... 369 DeLong, B N ...... 678 Ding, M ...... 1019* Duffin, R ...... 1193 Das, P C ...... 1209* Delongchamp, R R ...... 1717, 2419 Ding, W ...... 345, 435* Duffus, J ...... 711, 715* Das, R ...... 1085 DeLorme, M P ...... 2326* Ding, X ...... 687, 1833, 2434 Duffy, J ...... 260* Das, S ...... 2422 Delpit, E B ...... 1921 Dingemans, M ...... 1457* Duffy, P ...... 1984* Dash, B ...... 871 DelRaso, N ...... 170 Dingle, R ...... 210 Dugas, T R ...... 310 Dasmahapatra, A K ...... 150* DeLuca, R ...... 2270* Dinsmoor, P ...... 1668 Duhart, H ...... 1559 Daston, G ...... 402* Demady, D R ...... 608* Dionnet, F ...... 1187 Duistermaat, E ...... 1047 Daston, G P ...... 1551 Demchuk, E ...... 914* DiPalma, K ...... 2099 Dumas, R ...... 2388* Datiri, T ...... 2187 Dement, J D ...... 349 Diters, R W ...... 253 Dummer, K ...... 1589 Datta, K ...... 1678* Demeure, M J ...... 817 Divine, K ...... 438*, 1182 Dunaway, S ...... 1201 Daughtrey, W C ...... 1467* Demirbag, A E ...... 697 Diwan, B A ...... 58, 431 Dunlea, S ...... 987 Davey, M ...... 860 Den, A ...... 855 Dix, D ...... 2337 Dunn, A ...... 899 Davidson, T J ...... 253 Den, A R ...... 856 Dix, K J ...... 567* Dunn, R ...... 1534*, 1662, 1967 Davidson, T L ...... 2068 Dencker, L ...... 368 Dnyanmote, A V ...... 467*, 1008 Dunn, R T ...... 555 Davies, P H ...... 657, 658 Dene, H ...... 984 Dobbins, L L ...... 1568 Dunn-Rankin, D ...... 231 Davies, R ...... 796 Deng, K K ...... 901 Dobo, K L ...... 1130* Dunnick, J ...... 967, 2174* Davis, A ...... 998 Deng, X ...... 1711*, 1905 Dobson, R L ...... 1590 Dunnick, J K ...... 1655 Davis, B K ...... 881 Dengler, E K ...... 128 Doctor, B ...... 1924, 2350 Dunstan, R W ...... 1746 Davis, E ...... 73, 74, 75*, 1034 Denison, M ...... 354*, 787, 1543 Dodd-Butera, T ...... 1262* Durham, J ...... 589* Davis, J ...... 1426, 2065 Denison, M S ...... 353, 1263, 1930 Doerge, D R ...... 1943 Durham, S K ...... 245 Davis, M ...... 2063, 2150 Dennis, E A ...... 747* Doerrer, N ...... 2094* Durhan, E J ...... 1565 Davis, M A ...... 2, 289, 1013 Dennison, J E ...... 1278* Doherty, J ...... 669, 1425, 1428 Duringer, J M ...... 1406* Davis, M K ...... 862* Denoux, G ...... 1250 Doi, A ...... 2321 Durrer, S ...... 1928 Davis, R ...... 2317 Denslow, N D ...... 1082, 1352 Doi, Y ...... 1423* DuTeaux, S B ...... 1927* Davis, S ...... 2350 Deparade, E ...... 888*, 2319 Dolim, K ...... 548 Dutta, D ...... 1562* Davison, L ...... 1026 Derchak, A ...... 661, 1308 Doll, M A ...... 792, 793*, 799, Dux, J ...... 2339 Davison, L M ...... 678 Dere, E ...... 221*, 782, 985, 996 ...... 800, 968, 1370 Dwivedi, J ...... 1579* Day, B ...... 1714 Derk, R C ...... 390, 2102 Domico, L M ...... 1484* Dwivedi, S ...... 505* Day, B J ...... 508*, 638 Derkenne, S ...... 1810 Dominick, M ...... 982, 2089, 2095 Dybdal, N ...... 844 Day, B W ...... 472, 474*, 477 Desai, L ...... 550 Domoradzki, J ...... 2328* Day, C ...... 620 Desai, V ...... 1717* Donaghey, T ...... 1751 Day, G ...... 1907, 2392* Desai, V G ...... 835 Donald, J ...... 899 E Day, K C ...... 678* Descotes, J ...... 270, 271, 1742 Donaldson, K ...... 1198 Eagle, T M ...... 1002*, 1005 Day, T ...... 555 Desdouets, C ...... 1223 Donehower, L ...... 969 Earl, L K ...... 1286* Day-Lollini, P ...... 1075 Desert, P ...... 2104 Dong, H ...... 253, 1809* Early, R ...... 292 De Abrew, K N ...... 1342* Deshmukh, M ...... 1159* Dong, K ...... 1482 Easter, M D ...... 860* de Bruijne, K ...... 1060, 1702* DeSmet, K ...... 1113* Dong, W ...... 1879 Easterling, M ...... 1537, 1538, 2368* De Gagne, J ...... 1739* DeSmet, K D ...... 1085 Donlin, M ...... 1057 Easterling, M R ...... 2371, 2376 de Groot, D ...... 48*, 930 Desmeules, P ...... 395* Donnelly, K B ...... 289, 628, 629 Eastman, D ...... 1311 de Guzman, R ...... 1808* Desnlow, N D ...... 1935 Donnelly, K C ...... 525, 1250, 1251 Eastmond, D A ...... 178 de Heer, C ...... 896 Detrisac, C J ...... 1674 Donohue, J M ...... 2178*, 2300 Easton, M ...... 1089 de Jongh, H H ...... 2253 Dettbarn, W ...... 496 Donohue, M J ...... 371 Eastvold, M ...... 573 de Jouffrey, S ...... 1074, 2397 Dev, N B ...... 817 Donovan, E ...... 848* Eaton, D L ...... 717, 1815 De la Rosa, M ...... 112 Devesa, V ...... 413* Donthamsetty, S ...... 2145, 2157 Eaton, J ...... 503 de Peyster, A ...... 723, 1808 Devesa-Perez, V ...... 2356 Donthamsetty, S ...... 2146* Eaves, A ...... 1964 De Rosa, C ...... 1628, 1954 Devi, S S ...... 2137* Dooley, G ...... 1217* Ebersviller, S ...... 1060, 1702 De Souza, A T ...... 201*, 1692 Devine, H ...... 579* Doolittle, D J ...... 52 Eblin, K E ...... 425* De Vizcaya-Ruiz, A ...... 1184* Devine, P J ...... 393*, 395 Doorn, J ...... 494 Ebner, F F ...... 1448 De Wever, B ...... 1598 DeVito, M ...... 1169 Doorn, J A ...... 1095 Eckert, M ...... 966 Dean, I ...... 1287*, 1301 Devito, M J ...... 569, 1202 Dopp, E ...... 416* Eckhert, C ...... 1415 DeAngelo, A ...... 53 Devlin, R ...... 236 Dorman, D C ...... 11*, 22*, 24*, Eckhert, C D ...... 1414 up-to-date information at www.toxicology.org 261 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Eddy, E M ...... 400 Escobar, C ...... 2035* Fenske, R A ...... 388* Forrest, J ...... 998 Edelhauser, H F ...... 45, 1596 Espandiari, P ...... 124, 125*, 158, Fenton, S E ...... 399, 406, Forster, J ...... 80 Edmondson, R ...... 2142, 2395* ...... 295, 1665 ...... 1237, 2077* Forster, R ...... 523, 1074, Edwards, A ...... 911* Espejel-Maya, G ...... 2075 Ferguson, J A ...... 2387* ...... 1317, 2104, 2397* Edwards, B C ...... 590, 809 Espinosa Aguirre, J ...... 1824 Ferguson, S A ...... 1459, 2129 Fort, D J ...... 1570* Edwards, C N ...... 1980 Espiritu, I ...... 240 Fergusson, M ...... 1651 Fortin, M ...... 805 Edwards, J ...... 449, 2022* Estep, J E ...... 1921 Fernandez, C ...... 507, 992 Fortin, M C ...... 861* Edwards, J R ...... 1663 Estey, T ...... 468 Fernandez, C A ...... 469 Fortner, J ...... 620 Edwards, J Y ...... 2265* Estill, C T ...... 1406 Fernandez, S M ...... 397* Fortoul, T ...... 2076 Edwards, M R ...... 1258 Etoh, N ...... 877 Fernandez Canton, R ...... 1174*, 1951 Fortoul, T I ...... 2061, 2075*
AUTHOR INDEX AUTHOR Edwards, P ...... 96* EuDaly, J ...... 256, 288, 571, 1581 Ferng, J ...... 2392 Fortunato, G ...... 1401 Edwards, R E ...... 796 Eussen, S ...... 930 Ferrari, N ...... 805 Fosdick, A ...... 1534 Eells, J B ...... 1442* Eva, C ...... 2422 Ferrell, J ...... 1166, 1946 Foshay, E ...... 573 Eells, J T ...... 920, 1085*, 1113 Evans, D ...... 1082, 1296*, Ferriby, L ...... 1254 Fostel, J ...... 1072* Efe, S ...... 697 ...... 1298, 1617, 2222 Feucht, E L ...... 1819 Foster, E ...... 1585 Egan, B ...... 1071 Evans, M V ...... 1268, 1276, Feuston, M ...... 129 Foster, M ...... 1281*, 1282 Egnash, L ...... 623 ...... 2379, 2380, 2383 Fey, R ...... 250, 625 Foster, M W ...... 1134 Ehnes, C ...... 1928 Evans, P ...... 2273 ffrench-Mullen, J ...... 1086 Foster, P M ...... 2101* Ehrenfels, D M ...... 615 Evans, R A ...... 70, 71 Fielden, M ...... 182, 987, 993, 2392 Foster, W G ...... 1212* Ehresman, D ...... 2385* Evans, T ...... 1404 Fielden, M R ...... 169, 784*, 787 Foster, W M ...... 1044, 1138* Ehresman, D J ...... 576 Evansky, P A ...... 233 Figueroa, D J ...... 2133 Foth, H ...... 637* Ehrich, M ...... 318*, 1468*, Everds, N E ...... 2325, 2326 Filip, Z A ...... 817 Foulon, O ...... 940, 2104*, 2329 ...... 1469, 1800 Everett, D ...... 1313 Filipov, N M ...... 1486*, 1487, 1758 Fournier, S ...... 582, 1301 Ehrich, M F ...... 1466, 1467, Evering, W ...... 2249, 2343 Finch, G ...... 619 Fowler, B ...... 699 ...... 1470, 1801 Everitt, J ...... 1053 Finco-Kent, D ...... 1748 Fowler, B A ...... 448*, 1629 Eickman, E ...... 2123 Everitt, J I ...... 174 Fink, A L ...... 1098 Fowles, J ...... 2286 Einstein, D R ...... 35 Evje, L ...... 1785 Fink, G ...... 779 Fox, D A ...... 1790, 1791 Ejaz, S ...... 927 Ewing, P ...... 175, 1633* Fink, G D ...... 2058 Fox, G A ...... 1575 Ejaz, S ...... 874* Eynon, B ...... 987, 1907, 2392 Fink, M P ...... 2002 Foxenberg, R J ...... 95, 1207* Ekins, S ...... 668* Eyre, R ...... 169* Finkelstein, S D ...... 979* Frame, S R ...... 2325 Eklund, C ...... 2380 Eyton-Jones, H ...... 1231 Finlay, C ...... 2325 Francis, B ...... 153 Eklund, C R ...... 1268* Finley, B ...... 1612, 1632 Francoise, G ...... 251 El Gana, R ...... 1074, 2397 Finley, B L ...... 854, 1264, 1266 Francone, O L ...... 630 El Ghissassi, F ...... 385 F Finnell, R ...... 358 Frank, C B ...... 2439* El Majidi, N ...... 864, 1604* Fabian, E ...... 586* Finnell, R H ...... 1251 Franklin, C C ...... 489* El Sayed, W M ...... 1650*, 1826 Fadeel, B ...... 12, 16*, 1163 Fiori, J M ...... 880 Franklin, E E ...... 342, 2009 El-Fawal, H N ...... 1768 Fahl, W ...... 58 Fisch, C ...... 1074, 2397 Franklin, M R ...... 1650, 1826* El-Fawal, N M ...... 1768* Fahy, E ...... 749* Fischer, C ...... 1455* Fransen, M ...... 1629 El-Kadi, A O ...... 226, 2079, 2080 Faiola, B ...... 198* Fischer, K ...... 55 Frantz, J D ...... 245 El-Tawil, O S ...... 575* Fair, P ...... 1581 Fischer, T ...... 206 Fraser, J ...... 627 Elbekai, R H ...... 2080* Fakhrzadeh, L ...... 1064 Fishel, J ...... 1743 Frazer, A ...... 1057 Elcombe, C ...... 56*, 926 Falkenberg, F ...... 457 Fisher, A A ...... 2122* Frazer, D ...... 1057 Eldan, M ...... 2186 Fall, M ...... 523*, 1187 Fisher, C D ...... 2400 Frazier, J M ...... 1888 Elder, A ...... 1848*, 1852 Fallen, K ...... 1843 Fisher, G L ...... 303 Frech, S M ...... 392 Eldridge, J ...... 1932* Faller, C ...... 1600* Fisher, J ...... 2386 Fredrickson, C J ...... 1792 ElHage, J D ...... 333* Falluel-Morel, A ...... 1783* Fisher, J W ...... 1431, 2365, Fredriksson, A ...... 1455, 1456, 1458 Elizondo, G ...... 1331 Falotico, R ...... 293 ...... 2367, 2375 Freebern, W ...... 245 Ellinger, H ...... 447 Fan, A ...... 993 Fisher, C ...... 1334* Freedman, J ...... 40, 1493 Ellinger, M ...... 2176 Fan, A M ...... 728*, 883, 2189, 2313 Fiskum, G ...... 1111 Freedman, J H ...... 1082, 1178*, 1181, Ellinger-Ziegelbauer, H ...... 2220 Fan, R ...... 263, 325, 1899 Fitsanakis, V ...... 1844 1375, 2036 Elliot, G ...... 172 Fan, Y ...... 1686* Fitsanakis, V A ...... 1755, 1756* Freeman, C ...... 943, 1689 Elliot, G S ...... 308 Fang, H ...... 205, 245, 835, 2142 Fitzpatrick, J ...... 2333* Freeman, R W ...... 2192* Elliott, A A ...... 220* Fang, X P ...... 612 Fitzpatrick, R D ...... 2436 Freeman, W M ...... 2419 Elliott, G ...... 457 Fannin, R D ...... 1081* Fitzsimmons, M ...... 628, 629 Freidig, A ...... 1902* Ellis, G ...... 2275 Fanucchi, M V ...... 678, 724, Flack, S ...... 808* French, J E ...... 970*, 2027 Ellis-Hutchings, R ...... 934* ...... 1026*, 1027 Flagella, K ...... 844* Freshwater, L ...... 653 Ellisman, M H ...... 1791 Faqi, A S ...... 947* Flake, G ...... 1029 Freudenrich, T M ...... 1430 Elmore, A ...... 1426 Faravashi, N ...... 1907 Flaws, J ...... 7, 391, 1111 Friderichs-Gromoll, S ...... 2167 Elmore, S ...... 1666 Farin, F ...... 966 Flaws, J A ...... 392, 448, 867 Fridthjof, L ...... 375, 2265 Elsayed, N ...... 1916* Fariss, M W ...... 2130 Fleischmann, K ...... 1658 Fried, K W ...... 98* Eltom, S E ...... 359 fariss, m w ...... 741*, 742* Fletcher, B ...... 568 Friedman, M A ...... 166 Elwell, M ...... 619 Farmer, D R ...... 2336 Flickinger, G ...... 1500 Frijters, R ...... 997 Ema, M ...... 130*, 1213 Farmer, J D ...... 1491, 2411 Flood, A E ...... 137 Fritz, J ...... 1986 Emberger, H ...... 1845 Faroon, O ...... 1603 Florang, V ...... 1095 Fritz, S ...... 1845 Emberley, J K ...... 2010* Farooqui, M Y ...... 1735* Flowers, L ...... 380*, 382, 2208* Fritz, W A ...... 924* Enerson, B ...... 994, 1855 Farraj, A K ...... 233, 374* Floyd, E ...... 294, 1859* Froehlich, J ...... 576, 2385 Enerson, B E ...... 294* Farrell, D ...... 446 Floyd, G ...... 994 Froget, G ...... 1317* Eng, H ...... 659 Farrer, D G ...... 279* Foertsch, L ...... 378, 402 Fu, B ...... 539 Engel, A ...... 869 Fasano, W J ...... 815 Foertsch, L M ...... 1551 Fu, S ...... 548 Engel, E ...... 822* Fassih, A ...... 1135 Fogel, G ...... 553 Fu, X ...... 459, 1829* Engelberg, A ...... 1889 Fattori, V ...... 1454 Follansbee, M H ...... 858* Fuentealba, C ...... 1669 Engelhardt, J ...... 1675 Faulkner, B ...... 2384* Fomby, L ...... 180 Fuentes-Mattei, E ...... 1341* Engelhardt, S ...... 2071, 2072 Faust, J ...... 899 Fomby, L M ...... 1538 Fuetsch, M ...... 1928 England, E ...... 1723 Faust, J B ...... 910* Fong, C J ...... 985, 1337, 1340* Fuhrman, K ...... 1468 Ensley, S ...... 1528 Faustman, E M ...... 445, 898, Fontana, S ...... 1528 Fujii, S ...... 107 Entezari Zaher, T ...... 1186 ...... 1641, 1784, 2208 Foran, C ...... 2243 Fujii-Kuriyama, Y ...... 577 Eppig, J T ...... 984 Fawcett, S ...... 1369 Foran, C M ...... 2248* Fujikawa, M ...... 1906 Erdos, G ...... 1561 Fay, K A ...... 229* Forbes, A ...... 1446 Fujikawa, Y ...... 167* Erexson, G L ...... 555 Fay, M ...... 914 Forbes, B ...... 690 Fujimoto, S ...... 182, 1907, 2392 Erickson, H ...... 665 Fayer, J ...... 622 Forbes, P D ...... 818, 819, 2087* Fujimura, H ...... 492* Erickson, L E ...... 2202 Feather, G ...... 1046 Ford, A ...... 1879 Fujishiro, H ...... 2023* Ericson, J ...... 2245 Fedorowicz, A ...... 379 Ford, J J ...... 2112 Fukata, H ...... 1614, 1987, 2110 Eriksdotter-Jonhagen, M ...... 2052 Feeney, G P ...... 1087 Ford, M ...... 164 Fukatu, H ...... 865 Erikson, K ...... 1753*, 1844 Fehling, K ...... 1632 Ford, R ...... 2317* Fukui, H ...... 1094 Erikson, K M ...... 1755, 1763 Feinleib, M ...... 869 Ford, S M ...... 465 Fukunishi, K ...... 130 Eriksson, J ...... 1456 Felgar, R E ...... 1653 Foreman, B D ...... 485* Fukushima, S ...... 1228 Eriksson, P ...... 1455, 1456, 1458 Felty, Q ...... 304*, 949*, 1335, 1933 Forkert, P ...... 1880 Fukushima, T ...... 163, 1315 Erives, G V ...... 574* Feng, W ...... 642*, 1379 Forman, H J ...... 1511* Fukushima, Y ...... 626* Ernst, S W ...... 1281, 1282*, 1904 Feng, X ...... 789* Fornsaglio, J L ...... 2049 Fukuto, J ...... 535, 537 Ernstgard, L ...... 2303, 2382 Fennell, T ...... 166* Foronda, N M ...... 2286* Fukuto, J M ...... 486
262 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Fukuzaki, K ...... 667, 1316, Gavin, C E ...... 613 Giordano, M ...... 1769 Gorman, G ...... 603 ...... 1670, 1694, 2154 Gaviola, B ...... 80 Girigashanker, S ...... 2029 Gosselin, N ...... 1604 Fullard, M ...... 1843 Gazzana, G ...... 1659* Giroux, C N ...... 1118* Gosselin, N H ...... 864* Fulzele, S ...... 177, 840*, 1591 Gearhart, J ...... 69* Giulivi, C ...... 1500 Goswami, E ...... 850 Funk, W E ...... 2358* Geary, R S ...... 455, 602* Gjergji, O ...... 2178 Goto, H ...... 1704* Furlong, C E ...... 1446 Gebel, S ...... 1347 Glashkina, L ...... 2344 Gough, M ...... 1536* Furlong, J ...... 1446 Gebhart, A ...... 1606, 1607 Glass, C K ...... 750* Gould, S ...... 1857, 2168 Furr, J ...... 1168, 1233, 1545, 1939 Gee, S ...... 2362 Glass, T A ...... 51* Goulding, E H ...... 400 Furth, P A ...... 392 Gee, S J ...... 1518 Glauert, H P ...... 1221 Gowadia, N ...... 231* Furuhama, K ...... 458, 527 Gehman, E ...... 1121 Glaves, P D ...... 1386 Gowdy, C ...... 529 Furukawa, T ...... 2272 Gehring, R ...... 812 Gleit, A S ...... 2410 Gowdy, K ...... 1200 Fuscoe, J ...... 2142 Gelhaus, M ...... 382 Glenn, A E ...... 1993 Goyer, R A ...... 2055 Fuscoe, J C ...... 835, 1717 Gelineau-van Waes, J ...... 1492* Glenn, J ...... 876 Goytia, R C ...... 280* Fustinoni, S ...... 281 Gelineau-van Waes, J B .... 1496*, 1992 Glover, C ...... 1998* Goytia Acevedo, R C ...... 422* Gelzleichter, T R ...... 615* Glover, M ...... 263* Graczyk, T ...... 1611 Gemzik, B ...... 662, 2147 Gmuender, H ...... 192* Gradert, T ...... 606 G Genell, C ...... 2256 Goad, J ...... 1681, 1682 Graff, C ...... 132 Gabrielson, K L ...... 2151* Gennings, C ...... 884, 1203, 1627 Goble, R ...... 381 Graff, D W ...... 645 Gadagbui, B ...... 917*, 2297 Genovese, R ...... 69 Godard, C ...... 1587 Graff, J E ...... 1477*, 1478, 1479 Gaffney, S H ...... 1253* Genschow, E ...... 142 Godfrey, R J ...... 841 Grafstrom, R C ...... 1615 Gage, D ...... 623 Genter, M ...... 1877* Godin, S ...... 293 Gragg, R D ...... 2114 Gaido, K ...... 1364 Gentry, P ...... 1280 Godin, S J ...... 1202* Graham, D L ...... 2418* Gairola, C G ...... 1070 Gentry, P R ...... 2182* Godleski, J J ...... 2211* Graham, G A ...... 660 Gentry, R ...... 2296 Goebel, C ...... 42, 43, 518, Graham, J ...... 1923 Gakhar, G ...... 2202 AUTHOR INDEX Gakhar, G ...... 959* George, K ...... 1805* ...... 1588*, 1600, 2262 Graham, J P ...... 1035* Galambos, E ...... 1534 Georgieva, N I ...... 187*, 973 Goeden, H ...... 895* Graham, J R ...... 79 Galdanes, K ...... 1061 Gerard, M ...... 847 Goedken, M ...... 1001, 1367* Graham, M ...... 213, 1281, Gallacher, M ...... 2423 Gerberick, F ...... 377, 1836, Goel, S ...... 1302* ...... 1282, 1904 Gallagher, B S ...... 1911 ...... 2273, 2277 Goens, B ...... 2170 Graham, M J ...... 292, 308 Gallagher, E ...... 673 Gerberick, F G ...... 1590 Goering, P ...... 125 Graham, T ...... 2187 Gallagher, E P ...... 966* Gerberick, G ...... 378, 773*, 1140*, Goering, P L ...... 1667* Gralinski, M R ...... 664 Gallagher, J E ...... 406, 2077 ...... 1145, 1838*, 2275 Goetschi, A ...... 506 Gramatte, T ...... 472, 473*, 474, Galli, C L ...... 281, 282* Gerde, P ...... 1633, 1701* Goettel, O ...... 42 ...... 475, 476, 477 Gallicchio, L ...... 867 Gerdes, J ...... 2121 Goff, K ...... 135* Granato, T C ...... 1610 Gallis, B ...... 1437 Gerecke, D R ...... 1915* Gogal, R M ...... 283* Grant, D M ...... 580* Gallo, M ...... 952 Gerhold, D L ...... 2133 Gohil, K ...... 1068 Grant, G R ...... 796 Gallo, M A ...... 1322 Gerin, M ...... 916 Gohlke, J M ...... 1641, 1890* Grass, P ...... 788 Gallucci, R ...... 2402* Gerken, D ...... 180 Gokhale, V ...... 2122 Graves, L M ...... 640, 1014, 1513 Galvan, N ...... 526* Gerken, D F ...... 1422* Goktepe, I ...... 808 Graves, S ...... 1285*, 2352, 2363 Gandolfi, A J ...... 424, 425, 427*, 2078 Gerlofs-Nijland, M ...... 1193*, 1198 Gold, A ...... 187 Graves, S W ...... 1422 Ganey, P E ...... 97, 999, 1002, 1005, Germolec, D ...... 1750 Gold, R S ...... 1249 Gray, D ...... 1416, 1417*, 2332 ...... 1123*, 1708, 1710, Germolec, D R ...... 268, 1029, Goldberg, A ...... 317* Gray, D A ...... 1636, 1926 ...... 1711, 1718, 1905, 2148 ...... 1256, 2266 Goldberg, M C ...... 923 Gray, E L ...... 2113 Gangi, T ...... 1781 Gerrish, K ...... 1093 Goldberg, M T ...... 2287* Gray, J P ...... 481, 831, 1007, 1188* Gant, T W ...... 512 Gerten, S A ...... 1419 Golden, R J ...... 2190 Gray, L ...... 405, 1233, 1545 Ganter, B ...... 987, 1358*, 1889 Gerwick, W H ...... 1429 Goldenthal, E I ...... 2088 Gray, L E ...... 1168, 1939* Gao, H ...... 199, 1527, 1767 Geter, D ...... 53*, 54 Goldfarb, P M ...... 817 Gray, W G ...... 404 Gao, J ...... 264 Ghanbari, K ...... 567 Goldfarb, P S ...... 1173 Graziano, J H ...... 1757 Gao, S ...... 641, 1365* Gharavi, N ...... 226* Goldman, J M ...... 389 Greaves, M A ...... 698* Gao, X ...... 503*, 1069, 2109 Ghassemzadeh, S ...... 1791 Goldstein, B D ...... 717 Green, C ...... 1962, 1963 Gaoua-Chapelle, W ...... 940 Ghate, D ...... 45*, 1596 Goldstein, K ...... 2392 Green, D ...... 813 Garami, A ...... 2141 Ghio, A J ...... 235, 1051, 1180 Goldstein, L B ...... 1447 Green, L ...... 1639 Garantziotis, S ...... 1029 Ghosh, M ...... 987 Golka, K ...... 698 Green, O P ...... 1303* Garcha, J ...... 109 Ghosh, M C ...... 2062 Gollapudi, B ...... 556*, 1524 Green, S ...... 317 Garcia, E ...... 911 Ghosh, R N ...... 1960* Gollapudi, B B ...... 1084 Greenblatt, D J ...... 1004 Garcia, M D ...... 464 Giacomi, A ...... 1454 Golovkina, T ...... 245 Greene, A L ...... 1500 Garcia Boy, R ...... 1542* Giannunzio, L ...... 180 Golub, M ...... 899 Greene, J ...... 850* Garcia Hernandez, R ...... 863 Gibson, A B ...... 786 Golub, M S ...... 725* Greene, K J ...... 1565 Garcia-Arenas, G ...... 280 Gibson, A L ...... 1342 Gomez, A ...... 584 Greene, L ...... 1416 Garcia-Chavez, E ...... 1798* Gibson, D ...... 559 Gomez-Quiroz, L E ...... 2035 Greene, N ...... 1128*, 1130, Garcia-Jimenez, A ...... 1822* Gibson, J E ...... 552, 1418 Goncharov, N ...... 2344* ...... 1630, 1903*, 2143 Garcia-Montalvo, E A ...... 1256 Gibson, N ...... 547 Gonchoroff, D G ...... 253 Greenwell, R J ...... 363 Garcia-Reyero, N ...... 1082* Giddabasappa, A ...... 1790* Gong, B ...... 291* Greggs, W J ...... 1260 Garcia-Salcedo, J ...... 112 Gideon, K M ...... 1090, 1661 Gonsebatt, M E ...... 1769, 1824* Gregus, Z ...... 439* Garcia-Vargas, G ...... 280 Gies, R A ...... 189, 591* Gonzales, C ...... 2060 Grenet, O ...... 788, 1716 Garcia-Vargas, G G ...... 112 Giesige, M ...... 1241 Gonzalez, A ...... 1518 Grewal, I ...... 615 Gardea-Torresdey, J ...... 1563 Gifford, E ...... 298 Gonzalez, F J ...... 1004, 1321, 1810 Grey, B E ...... 937* Gardiner, C S ...... 1828 Gift, J S ...... 891, 2308 Gonzalez, H ...... 444* Gribble, E J ...... 445, 1641, 1784* Gardner, C R ...... 1007* Gigliotti, A ...... 634 Gonzalez, N ...... 521 Griem, P ...... 2275 Gardner, D ...... 2317 Gil, J ...... 269 Gonzalez-Flecha, B ...... 2211 Griffith, W ...... 898 Gardner, R M ...... 284*, 1175 Gilbert, J R ...... 1493 Goodlett, D R ...... 1437 Griffith, W C ...... 1641* Garey, J ...... 1459* Gilbert, K ...... 1901* Goodman, D ...... 2350 Griffiths, J C ...... 763 Gargas, M L ...... 2301 Gilbert, M ...... 1425 Goodman, J E ...... 2186 Griffiths, W ...... 2153 Garner, C ...... 568 Gilbert, M E ...... 335, 338*, 1433 Goodman, J I ...... 52, 889, Griftiths, C ...... 2260 Garofalo, R P ...... 1373 Gilbert, S G ...... 718*, 719* ...... 1224, 1226* Grippo, A A ...... 2162* Garrett, C M ...... 836, 837, 838* Gilbert, S J ...... 349 Goodrum, P E ...... 858 Grippo, R S ...... 2162 Garrett, R M ...... 914 Gildea, L ...... 378* Goodsaid, F ...... 1856 Grivas, P ...... 2406 Garrett, S H ...... 2033, 2038, 2039*, Gildea, L A ...... 1142* Goodwill, M H ...... 1100* Grivas, P C ...... 2407* ...... 2041, 2042, 2081 Gilkeson, G ...... 288, 571 Goodwin, S ...... 1540 Grizzle, T B ...... 618* Garrido, E ...... 428 Gill, P K ...... 2003 Gooler, D M ...... 1453 Grollman, A P ...... 554* Garry, M R ...... 2188, 2199* Gillard, E R ...... 94 Gopee, N V ...... 822, 829, 835* Groom, S ...... 179, 648, 1391*, 2360 Garside, H J ...... 213* Gillespie, A M ...... 525 Gopinath, C ...... 2331 Groot, M J ...... 1170 Garton, D ...... 2063 Gillies, P J ...... 2325 Gorbunov, N V ...... 1382* Grosovsky, A J ...... 526 Garza-Ocanas, L ...... 1401* Gillilland, C D ...... 1613 Gordon, C J ...... 1521, 1522* Gross, E A ...... 1294, 2117* Gasiewicz, T A ...... 212 Gillis, T ...... 1310 Gordon, J D ...... 1263, 1930* Gross, G W ...... 1480, 1792 Gasper, C ...... 134* Gillman, M ...... 2232 Gordon, M K ...... 1915 Gross, J A ...... 364* Gato, W E ...... 2056* Gilmour, I ...... 236*, 249, 1199, 1200 Gordon, R ...... 1924*, 2350 Gross-Steinmeyer, K ...... 1815* Gaul, C ...... 364 Gilotti, A C ...... 2274 Gordon, R K ...... 79 Grosse, Y ...... 385 Gautier, J ...... 1894 Gingerich, J ...... 1961 Gordon, T ...... 709*, 1039, 1061 Grossi, I M ...... 2363 Gavett, S H ...... 233*, 374 Giordano, G ...... 1438, 1472*, 2006* Gore, J C ...... 1755 Groten, J ...... 930 up-to-date information at www.toxicology.org 263 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Grove, L E ...... 1960 Haggerty, H ...... 2242* Harbell, J W ...... 912, 1595*, 1958 Hebert, V Y ...... 310 Groves, A ...... 1092 Haggerty, H G ...... 245, 253* Harbison, R ...... 2406 Heck, D E ...... 831, 1188 Grundy, J M ...... 556, 1248, 1524 Hagino, S ...... 2283 Harbison, R D ...... 853, 2407 Hedtke-Weber, B M ...... 567 Grune, G ...... 1930 Hagiwara, A ...... 1421, 1423 Harbo, S J ...... 1661 Heflich, R ...... 1685 Grzemski, F A ...... 1678 Hagmar, L ...... 384 Hard, G C ...... 463 Hege, A ...... 316, 1616* Gu, B ...... 2434 Hagos, G K ...... 1645* Hardej, D ...... 1687, 1913* Heggland, S J ...... 2015 Gu, J ...... 687*, 1833 Hagstrom, J E ...... 201 Harder, J ...... 1983* Hei, T ...... 347 Gu, M ...... 468 Hahn, J ...... 1252 Hardman, R ...... 1955* Hei, T K ...... 350* Gu, X ...... 1322*, 1330 Hahn, R A ...... 1915 Hardy, C J .. 657, 658, 660, 1699, 1700 Heideman, W ...... 128, 2160, 2172 Gualdoni-Holmes, B ...... 2343 Hahn-Quintes, S ...... 211 Harford, A J ...... 1736 Heidenfelder, B ...... 406, 2077
AUTHOR INDEX AUTHOR Guan, X ...... 1564 Haigh, J R ...... 2350* Hargreaves, A ...... 1222 Hein, D W ...... 17*, 21*, 792, Guarisco, J A ...... 1991* Haighton, L A ...... 2345 Harkema, J ...... 22, 1041 ...... 793, 794, 799, Guastadisegni, C ...... 1198 Haimes, H B ...... 616 Harkema, J R ...... 9*, 23*, 35, ...... 800, 968, 1370 Gubbels, I ...... 1971* Hajela, R K ...... 1779, 2058 ...... 261, 398, 1028, Hein, M J ...... 349 Gudi, S ...... 2119 Hakamata, S ...... 2272 ...... 1066, 1852*, 2213 Heindel, J J ...... 1860, 2232 Guenther, B ...... 364, 1426 Halbert, D ...... 182 Harkness, J R ...... 2410 Heinloth, A N ...... 1000* Guergues, D ...... 650 Halbert, D N ...... 1907, 2392 Harmon, A W ...... 440 Heitfeld, F A ...... 1625 Guerin, A ...... 2355* Haldosen, L ...... 360, 361 Harney, A S ...... 82* Hejtmancik, M ...... 180, 1538, 2321 Guerrero Almeida, M ...... 280 Halinen, A I ...... 238, 239 Harouchi, H ...... 1748 Hejtmancik, M R ...... 1422 Guerrero-Almeida, M ...... 112 Hall, A H ...... 847, 1587 Harper, C ...... 1629 Hejzlar, Z ...... 2348 Guerriero, F J ...... 1299, 2276 Hall, J O ...... 1991 Harper, R ...... 1185 Helbig, L ...... 471 Guichard, J ...... 1742 Hall, K ...... 2406* Harper, S L ...... 145* Heldring, N ...... 360, 361 Guilarte, T ...... 4 Hall, K M ...... 1319, 1320 Harrill, J A ...... 1483* Helene, B ...... 251 Guilarte, T R ...... 502, 1842*, Hall, K W ...... 2407 Harriman, J F ...... 2322* Helguro, L ...... 360, 361 ...... 1845, 1846* Hall, L ...... 789 Harrington, Y ...... 1296, 1298 Helmcke, K J ...... 1785* Guilfoil, A J ...... 841 Hall, M L ...... 1396 Harris, C ...... 568 Hemmer, M J ...... 1568* Guillot, T S ...... 1112 Halladay, A ...... 1781 Harris, J ...... 953, 1231 Henderson, J D ...... 785 Guindon, K A ...... 1649* Hallberg, C C ...... 797 Harris, M ...... 1536 Henderson, K A ...... 1415* Guiney, P D ...... 1570 Hallberg, C S ...... 701 Harris, M A ...... 1254* Henderson, M ...... 2386 Guizzetti, M ...... 1437, 1438 Halmes, C ...... 2192 Harris, P S ...... 1568 Hendrich, S ...... 272 Gul, H ...... 118* Halmes, N C ...... 866 Harris, R ...... 1416*, 1417 Hendricks, C A ...... 560* Gulson, B ...... 2063, 2065* Halstead, B W ...... 1527 Harris, R K ...... 594 Hendricks, J D ...... 1227 Gulumian, M ...... 533* Hamada, Y ...... 654 Harrison, L S ...... 1219 Hendrickson, C ...... 911 Gundersen, D ...... 1585* Hamade, A ...... 2175 Harrison, R ...... 590 Hendrickson, J ...... 1500 Gundersen, H ...... 48 Hamadeh, H K ...... 171, 172 Harrison, S ...... 1750 Hendriks, H ...... 930 Gungon, K ...... 993 Hamadeh, h ...... 314* Hart, B ...... 1923 Heneweer, M ...... 1170* Gungor, G ...... 118 Hamano, T ...... 1949, 2250* Hart, J ...... 573 Hengstermann, A ...... 1347* Gunnarsson, D ...... 2025 Hamelin, G ...... 565*, 1273 Hartgring, S ...... 48 Henk, W G ...... 1054 Gunnison, A ...... 1061 Hamilton, J D ...... 1625 Hartmann, L M ...... 416 Hennig, B ...... 91, 305 Guo, C ...... 464* Hamilton, J W ...... 421 Hartwig, A ...... 1177, 1183* Henry, E C ...... 212 Guo, J ...... 2159 Hamilton, S B ...... 1540, 1541 Haruyama, M ...... 667 Henry, M M ...... 1085, 1113 Guo, L ...... 205* Hamirani, A ...... 2085 Harvey, E ...... 1671, 1968, 1970 Henry, S ...... 292* Guo, Q ...... 419 Hamlin, R ...... 1529, 2176 Harvison, P J ...... 2408, 2409 Henry, S P ...... 250, 308, Guo, T L ...... 268, 274, Hamm, J T ...... 531, 801*, 2338 Hasegawa, R ...... 1333* ...... 456, 602, 625 ...... 278*, 2266 Hammer, F ...... 1606, 1607 Haseman, J ...... 1968, 1970 Henseler, M ...... 1928 Guo, W ...... 526, 981 Hammock, B D ...... 1518*, 2362 Haseman, J K ...... 889, 907 Henseler, R A ...... 1731* Guo, X ...... 1748 Hammond, C L ...... 1161 Haskard, C ...... 1736 Henshel, D S ...... 920 Guo, Y ...... 199* Hammond, T ...... 652, 1533 Haskins, J R ...... 493, 511 Henson, C ...... 587* Guo, G l ...... 1321* Hammond, T G ...... 1461 Hassani, M ...... 2121* Hentz, N G ...... 2144 Guo-Ross, S X ...... 1444* Hamre, D ...... 652 Hassenbusch, S ...... 606 Heo, J ...... 2064 Gupta, A K ...... 662 Han, D ...... 1049 Hassinger, J N ...... 599 Hepfner, E ...... 516 Gupta, R ...... 391*, 392, Han, E ...... 85, 677, Hassler, C R ...... 2176* Herberth, M ...... 2165, 2437* ...... 1111, 1474 ...... 1216, 1371, Hassoun, E A ...... 491* Herden, C J ...... 1779* Gupta, R C ...... 496*, 1681, ...... 1393, 1403, 1813* Hastings, C ...... 586, 1432 Herlich, J ...... 789 ...... 1682, 1756 Han, E H ...... 86 Hastwell, P W ...... 41 Herman, E ...... 125 Gupta, T ...... 2211 Han, J ...... 500, 2064 Hasumura, M ...... 1996 Herman, E H ...... 295, 1665 Guri, G ...... 2051 Han, J H ...... 1752 Hatch, G ...... 1061 Herman, J ...... 334 Gurley, B J ...... 2162 Han, K ...... 1049 Hatch, G E ...... 1063 Herman, J K ...... 649 Gurofsky, S ...... 102 Han, L ...... 539 Hatcher, E ...... 250 Herman, L ...... 753 Gustafson, A ...... 368 Han, M ...... 1339, 1359 Hatcher, J M ...... 1112* Hernandez, D M ...... 274*, 278 Gustafsson, J ...... 360, 361 Han, S ...... 1339, 1359, 1938 Hattis, D ...... 381* Hernandez, E ...... 2035 Guthrie, J ...... 1416 Han, S G ...... 1070* Hauber, S ...... 1966 Hernandez, J P ...... 1327, 1830* Gutierrez, M ...... 1571* Hanberg, A ...... 88 Hauber, S A ...... 1601 Hernandez, L G ...... 1880* Gutierrez V., A ...... 2061 Hancock, J ...... 1956 Hawas, O ...... 2063 Hernandez, M ...... 521 Gutierrez-Ospina, G ...... 1769 Hancock, J T ...... 1956 Hawes, M ...... 175 Hernandez-Martinez, J ...... 62 Gutierrez-Ruiz, M ...... 2035 Hancock, S ...... 1466, 1800 Hawk, M ...... 2176 Hernandez-Ochoa, I ...... 2057* Gutjahr-Gobell, R E ...... 1566 Hancock, S K ...... 1801 Hawkins, B E ...... 495* Hernandez-Serrano, M ...... 280 Gutleb, A ...... 384 Hanes, J L ...... 289 Hawks, R ...... 134 Hernandez-Serrano, M C ...... 112* Guy, V ...... 251 Hanig, J ...... 124, 125, 126, Hawryluk, P ...... 666 Hernandez-Zavala, A ...... 428*, 1256 Guzelian, P S ...... 1341 ...... 158, 295, 296 Hayasaki, Y ...... 527* Hernhag, C ...... 1574 Guzman, R ...... 1678 Hanig, J P ...... 1665 Hayashi, M ...... 2150 Herouet-Guicheney, C ...... 2254 Guzman, R E ...... 1746 Hankinson, O ...... 228, 964, Hayden, E ...... 2202 Herr, D W ...... 1477, 1478*, 1479 Gwiazda, R ...... 188*, 1765 ...... 1369, 1835 Hayden, P ...... 396, 1201, 1593 Herweijer, H ...... 201 Gwinn, M R ...... 543* Hanneman, W H ...... 217, 597, 1097, Hayden, P J ...... 44, 319*, 559 Herzyk, D J ...... 2238*, 2256 ...... 1947, 2370* Haykal-Coates, N ...... 233, 374 Hess, F ...... 1432 Hansen, D ...... 1984 Hays, S ...... 114 Hess, K ...... 830, 1723 H Hansen, H ...... 914, 1603, 1628 Hays, S M ...... 2378* Hess, R ...... 1548 Ha, C S ...... 1690 Hansen, J ...... 1360* Hayward, I ...... 1675 Hessner, M ...... 394, 1617 Ha, J ...... 581, 605 Hanson, J ...... 2138 Hazarika, S ...... 2202 Hester, S ...... 426*, 1205, Haapakoski, R ...... 372 Hanson, N ...... 1944 He, L ...... 1250, 1368*, 2024, ...... 1206, 1229 Haas, R ...... 506 Hanspers, K ...... 898 ...... 2029, 2030, 2403 Hesterberg, T ...... 860 Haasch, M L ...... 150 Hanton, G ...... 1859 He, Q ...... 1179*, 1394, 1395 Hestermann, E V ...... 225 Haber, L ...... 890 Hao, X ...... 609 He, X ...... 1805, 2046* Hetheridge, M ...... 2245 Haber, L T ...... 1640* Happo, M ...... 239 He, Y ...... 201 Heugens, E ...... 2381 Habermann, G ...... 2167 Happo, M S ...... 238* He, Y D ...... 1692 Heusener, A ...... 598 Hachiya, N ...... 107 Hara, T ...... 1530* Healan-Greenberg, C ...... 1819* Heussner, A H ...... 472*, 473, Hack, E ...... 890, 1277*, 1640 Harada, K ...... 105, 106, Healy, L ...... 1534 ...... 474, 475, 476, 477 Hackman, R M ...... 1979 ...... 107, 108, 2435* Hearne, L B ...... 1405 Hew, K W ...... 611*, 612 Haddad, S ...... 1273* Harada, T ...... 654 Hebert, N ...... 651* Heydens, W F ...... 2336* Haddouk, H ...... 523 Harbell, J ...... 1599, 1970 Hebert, P ...... 1744* Heyliger, S O ...... 1211
264 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Heyob, K M ...... 123 Hong, S ...... 445, 1612*, 1784, 2363 Hurst, C ...... 252*, 608 Ishizuka, Y ...... 492 Hiatt, G F ...... 856* Hongping, D ...... 1259 Hurst, N W ...... 550 Isla, M ...... 1107 Hickey, A J ...... 1703 Honma, M ...... 536 Hursting, S ...... 1508* Islam, Z ...... 261, 1028* Hickling, K ...... 1281 Honma, T ...... 1451*, 2109 Husain, A ...... 21, 1370 Islamzadeh, A ...... 1250 Hickman, S ...... 1307 Hood, C A ...... 2353* Husain, K ...... 307* Isse, T ...... 193, 676, 693, Hicks, H ...... 1628, 1954* Hood, D B ...... 1436, 1448*, 2096 Hussain, M M ...... 1700* ...... 798*, 868, 2269 Hicks, J ...... 850 Hooper, M ...... 1191 Hussain, S ...... 37, 830, 1723, 2361* Itagaki, H ...... 2279, 2283 Hidalgo, I J ...... 1966 Hooser, S B ...... 7* Hussain, S M ...... 1559, 1888, 2200 Itai, A ...... 2128 Hideki, F ...... 140 Hooth, M ...... 1671 Hutchinson, T ...... 2245 Itamura, R ...... 120* Hierlihy, L ...... 101, 102 Hooton, D ...... 873* Hutchison, C ...... 2437 Ito, K ...... 206 Higashiyama, H ...... 636, 2166* Hoover, S M ...... 899 Hutto, D ...... 132, 608, 634 Ito, T ...... 1749 Higgings, L ...... 1941 Hopke, P K ...... 706* Huttunen, K ...... 2012 Ito, Y ...... 2281*, 2282 Higgins, A ...... 162 Hopwood, J ...... 2135* Hutz, R J ...... 394 Itoh, K ...... 978, 2442 Higgins, M A ...... 171*, 1527 Horai, N ...... 1694* Hwang, I ...... 605 Itoh, S ...... 527 Hijioka, M ...... 2154 Horand, F ...... 270, 271*, 1742 Hwang, J ...... 1195 Ivanov, V ...... 1398 Hikosaka, A ...... 962 Hore, S K ...... 2288 Hwang, M ...... 450, 1794* Iversen, P L ...... 599 Hildebrand, K ...... 606 Horiguchi, H ...... 865, 1023, 2031* Hwang, S ...... 1018, 2013* Iwachido, T ...... 1620 Hiles, R ...... 2090* Horii, I ...... 120, 163, Hwang, Y ...... 677, 1216, 1351*, Iwashita, K ...... 1392 Hill, C E ...... 701*, 797, 2355 ...... 654, 1091, 1906 ...... 1371, 1400, 1403, 1407, Iyer, P ...... 899 Hill, D ...... 358 Horimoto, M ...... 120 ...... 1409, 1410, 1412, 1813 Izumi, H ...... 1094 Hill, G ...... 1053 Horinouchi, A ...... 1094 Hwang, Y P ...... 86 Hill, R A ...... 688 Horn, T L ...... 1674*, 1676, 1982 Hyde, D ...... 9 Hillamo, R ...... 239 Hornbuckle, K C ...... 588 Hyndman, K ...... 1082 J Hillegas, A ...... 2256 Hornik-Rosinski, V ...... 1658 Hynes, J ...... 1908, 1909 Jack, D ...... 293 AUTHOR INDEX Hillegass, J ...... 149 Hornung, M W ...... 1572*, 1573 Jackson, D ...... 1121* Hillegass, J M ...... 151* Horohov, D ...... 804, 1040 Jackson, D A ...... 1380 Hillenbrand, R ...... 788 Horsman, M ...... 1033 I Jackson, E R ...... 1684* Himeno, S ...... 411, 2023 Horsmon, M ...... 73, 74*, 80 Iatropoulos, M J ...... 303, 616, 2083 Jackson, G R ...... 1593* Himmelstein, M W ...... 1275* Horton, J ...... 2174 Ibrahim, H ...... 610, 1531 Jackson, K M ...... 674 Hinckley, J ...... 1466, 1800, 1801 Hosea, R ...... 2313 Ibrahimoglu, L ...... 118 Jackson, M ...... 967* Hinderliter, P M ...... 591, 1526*, 2127, Hotchkiss, J A ...... 1052*, 1521* Ichihara, G ...... 2434* Jackson, M D ...... 2430 2308 Hou, B ...... 94 Ichihara, S ...... 2434 Jackson, M I ...... 486* Hines, E P ...... 399, 406*, 1237, 2077 Hovland, D ...... 1548 Ichihara, T ...... 1421*, 1423 Jacob, H ...... 1296, 1298 Hinson, J P ...... 1173 Howard, A ...... 1033, 1441 Ichisaki, S ...... 667 Jacob, H J ...... 1617 Hinton, D ...... 138, 148, 1955 Howard, A S ...... 891*, 1031, 1032 Iciek, L ...... 253 Jacob, R ...... 620 Hirabayashi, Y ...... 577*, 1091 Howard, P C ...... 822, 829, 835 Iden, C R ...... 554 Jacob, R E ...... 35 Hiraga, T ...... 1120 Howd, R A ...... 728, 883, 1602, 2189 Igarashi, I ...... 2272 Jacobitz, A ...... 613 Hirani, A A ...... 1469 Howdeshell, K ...... 1233 Igarashi, K ...... 57 Jacobs, A ...... 772* Hirner, A V ...... 416 Howdeshell, K L ...... 405, 1168, 1545* Igboeli, O O ...... 1424 Jacobs, L ...... 593 Hirode, M ...... 1078* Howell, K ...... 615 Ignagni, A ...... 1658 Jacobson, P B ...... 1396 Hirosawa, I ...... 107 Hoyer, P B ...... 397, 1550 Ihara, T ...... 130 Jacobson Kram, D ...... 2094 Hirose, A ...... 130 Hoying, J B ...... 397 Ihnat, M A ...... 421* Jacobson-Kram, D ...... 731* Hirose, M ...... 57, 972, 978, Hrubec, T C ...... 367* Iida, T ...... 865 Jacquinet, E ...... 446, 2360 ...... 1996, 2134 Hsu, C ...... 1220 Iidaka, T ...... 1315 Jaeckh, R ...... 940 Hirota, M ...... 2283 Hsu, E L ...... 1369* Ikeda, M ...... 107, 2442 Jaeger, R J ...... 2059 Hirvonen, M ...... 238, 239, 2012 Hsuan, S ...... 1109 Ikeda, S ...... 1333 Jaeschke, H ...... 1003, 2222, 2223* Hixon, M ...... 2099 Hu, C ...... 1089, 1834 Ikeda, Y ...... 1949 Jahng, Y ...... 682, 683 Hlastala, M ...... 34, 35 Hu, J ...... 548* Illanes, O ...... 1669 Jakowski, A ...... 2016 Ho, C ...... 1634 Hu, N ...... 143 Illouz, K ...... 1540*, 1541 Jakubowski, E ...... 69 Ho, J W ...... 1693* Hu, R ...... 1534, 2150* Ilvesaro, J ...... 1680 Jakubowski, E M ...... 68, 70*, 71, 77 Ho, S ...... 935 Hu, T ...... 44, 559 Im, J ...... 1076 Jakupciak, J ...... 1205* Hoberman, A M ...... 818, 819, Hu, W ...... 787, 1805, 2337* Imai, N ...... 1421 Jalava, P ...... 238, 239* ...... 933, 938, 2087 Hu, X ...... 957 Imai, T ...... 1996* Jalowayski, A A ...... 2340 Hochman, D ...... 2251* Hua, P ...... 1532 Imazawa, T ...... 2134 Jamalfar, S ...... 2153 Hochwalt, A E ...... 1260 Hua, Y ...... 1103 Inaba, Y ...... 2043 James, M O ...... 1935 Hodge, E ...... 913* Huang, C ...... 92 Inada, N ...... 1423 James, R C ...... 99, 866, 2192 Hodge-Bell, K ...... 964 Huang, F ...... 2434 Inan, S Y ...... 1452 Jameson, R R ...... 1440* Hodgson, E ...... 1209 Huang, N ...... 621, 622 Inayat-Hussain, S H ...... 1099, 1165* Jang, D ...... 450, 1794 Hoehle, S I ...... 675 Huang, Q ...... 462*, 1093 Inga, A ...... 703 Janice, C ...... 1476 Hoffman, E A ...... 35 Huang, W ...... 1001, 1327 Ingerman, L ...... 2298* Jansink, R ...... 930 Hoffman, K ...... 1380* Huang, Y ...... 1558 Ingmanson, S ...... 1262 Janssen, N ...... 1198 Hoffman, T ...... 1923 Huckle, R M ...... 660* Inhof, C J ...... 1606* Janssen, P ...... 673 Hoffmann, G ...... 203 Hudgens, E ...... 762 Inman, A O ...... 824, 825*, 827 Jarabek, A M ...... 2117 Hofmann, E L ...... 347*, 347* Hudson, L G ...... 434, 435 Inoue, H ...... 1048, 2166 Jarema, K A ...... 1491 Hofmann, M ...... 37 Huebner, H ...... 1577 Inoue, K ...... 57, 105, 106, 107, 108* Jarnagin, K ...... 1889, 2392 Hogaboam, J P ...... 277* Huebner, H J ...... 871 Inoue, S ...... 107 Jarnberg, J ...... 1623 Hogstrand, C ...... 1087*, 1998 Huffman, M ...... 199 Inoue, T ...... 577, 1091, 1091 Jarvelainen, H ...... 1680* Hohn, A ...... 192 Huggett, D ...... 2245 Inoue, Y ...... 2442 Jarvis, J R ...... 72 Hoitink, M ...... 1971 Huggett, D B ...... 2243*, 2244* Inyang, F ...... 2096 Jaskot, R ...... 1062, 1063, 1194 Hoivik, D ...... 198 Huggins, D J ...... 716 Ioannou, N ...... 2293 Jaspers, I ...... 639, 640, 1060, Holcombe, G ...... 1941 Huggins, J ...... 711*, 714* Ioannou, Y M ...... 2293* ...... 1065, 1199, 1200, Holcombe, G W ...... 1573, 1942 Hughes, M F ...... 569, 590, Iordanidis, L ...... 2077 ...... 1702, 2210, 2214 Holden, L ...... 50 ...... 809*, 1202, 2380 Iordanova, V ...... 942* Javorina, A ...... 1559* Holladay, S D ...... 136, 137, 283, 367 Hui, Y ...... 621, 622* Ip, C ...... 1677, 1962, 1963 Jayadev, S ...... 462, 1093, 1738 Holland, R ...... 2142 Hulderman, T ...... 1555 Iregren, A ...... 2303 Jayaraj, K ...... 187 Holland, R D ...... 200, 2395 Hulet, S W ...... 70, 72* Ireson, R ...... 860 Jayaram, B ...... 594 Holley, G ...... 45, 1596* Huljic, S ...... 471* Irizarry, A ...... 199 Jayaraman, S ...... 1566 Hollingshead, B D ...... 208 Hull, S ...... 1262 Irwin, R ...... 1000 Jean, N ...... 2390* Holloway, A C ...... 1212 Humes, D ...... 1336* Irwin, R D ...... 2132 Jean, P A ...... 1827*, 1940 Holloway, G ...... 529 Humes, D G ...... 227 Isaacs, K R ...... 1223 Jefcoate, C ...... 2232* Holm, S E ...... 2190 Humphreys, B D ...... 469 Isabelle, M ...... 1187 Jeffcoate, C ...... 2237* Holman, P S ...... 1564 Hung, D ...... 1220* Isbell, M A ...... 647 Jefferson, W ...... 2235 Holmes, A L ...... 519* Hung, G ...... 250 Iscan, M ...... 697* Jefferson, W N ...... 400* Holmes, E ...... 161 Hung, P ...... 2107* Ise, R ...... 1094* Jeffery, E H ...... 1004 Holmuhamedov, E L ...... 1715 Hung, S ...... 985*, 1084 Ishak, M H ...... 1165 Jeffrey, A ...... 2083 Holson, J F ...... 1239 Hunt, J A ...... 1004 Ishibashi, A ...... 1906 Jeffrey, A M ...... 616* Holz, J D ...... 1376 Hunt, R E ...... 1921 Ishida, S ...... 702 Jeffries, H ...... 1060, 1065, 1702 Honarvar, N ...... 2262 Hunter, D ...... 2284 Ishiharada, N ...... 1704 Jeffries, H E ...... 2214 Hong, D ...... 824 Hunter, D L ...... 46, 1475* Ishii, Y ...... 972, 978 Jelakovic, B ...... 554 Hong, J ...... 605, 1805, 1938 Hurley, B ...... 1476 Ishino, F ...... 925, 2100 Jendrzejewski, J L ...... 816 up-to-date information at www.toxicology.org 265 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Jenniskens, F A ...... 123 Johnston, M B ...... 2144 ...... 1379, 2152, 2156 Kenyon, E M ...... 2380* Jensen, J A ...... 878 Jolette, J ...... 446, 610 Kanki, K ...... 978, 2134 Kenyon, N J ...... 1068 Jensen, K A ...... 1343 Jolly, R ...... 199 Kannan, E ...... 1978 Kerdine, S ...... 1143 Jensen, K M ...... 1565 Jolly, R A ...... 1527 Kanno, J ...... 57, 155, 577, 2128 Kerdine-Roemer, S ...... 1734* Jensen, N ...... 689* Jolly, R H ...... 2392 Kanno, T ...... 790 Kerger, B D ...... 99*, 561, 570, 1536 Jensen, N S ...... 793 Jonas, W ...... 1865* Kanthasamy, A ...... 4, 1766, Kerkvliet, N ...... 1656 Jenssen, B M ...... 1574 Jonas, W B ...... 1869* ...... 2007, 2008 Kerlin, R L ...... 630 Jeon, J ...... 2340 Jones, C ...... 1206, 1229 Kanthasamy, A G .... 1766, 2007, 2008 Kern, C ...... 1765* Jeon, T ...... 247*, 672, Jones, C S ...... 1950 Kanz, M F ...... 2139* Kern, P ...... 377 ...... 682, 684, 1817 Jones, D E ...... 283 Kapetanovic, I ...... 1677 Kern, P S ...... 1132*, 2277
AUTHOR INDEX AUTHOR Jeon, Y J ...... 1356* Jones, D P ...... 1110, 1360 Kapetanovic, I M ...... 601, 1674, Kerr, H M ...... 1942 Jeong, E ...... 581*, 605 Jones, H ...... 1857 ...... 1676, 1982, 1983 Kerri, L ...... 1417 Jeong, H ...... 85, 86, 247, 677, Jones, H B ...... 2168* Kaphalia, B S ...... 287, 691*, 692 Kerzee, J K ...... 1877 ...... 1216, 1218, 1345, 1350, Jones, J ...... 253, 2295 Kaplan, B L ...... 1732* Keshava, C ...... 55, 380, 382 ...... 1351, 1371, 1393, 1400, Jones, K ...... 2135 Kappler, M ...... 1252 Keshava, N ...... 1635* ...... 1403, 1407, 1408, 1409, Jones, R ...... 180, 1090 Kapralov, A A ...... 1158, 2003, 2004 Kester, J E ...... 2296* ...... 1410, 1411*, 1412, 1813, Jones, R C ...... 2395 Karanth, S ...... 1473*, 1474 Keun, H C ...... 161 ...... 1817, 2018, 2440 Jones, R D ...... 1305 Karasov, W H ...... 364 Key, P B ...... 1563 Jeong, K E ...... 1959 Jones, T W ...... 752* Kariya, C T ...... 508, 638* Keyhani, A ...... 610, 612 Jeong, M ...... 2334 Jong, P C ...... 1174 Karla, T ...... 1515 Khalil, R ...... 2433* Jeong, S ...... 273, 791*, 2268 Jordan, H ...... 198 Karuri, A R ...... 1707* Khambatta, Z S ...... 1551 Jeong, T ...... 247, 672, 677, Jordan2, V ...... 358 Kasahara, Y ...... 1378 Khan, M ...... 185*, 1022, 1720 ...... 682, 683*, 684, Jortner, B S ...... 1466*, 1467, Kasai, H ...... 1694 Khan, S ...... 209, 358, 1246, 1673* ...... 1813, 1817 ...... 1470, 1800, 1801 Kashari, M ...... 2178 Khan, W ...... 1447 Jergil, M ...... 368 Joseph, P ...... 1179, 2044 Kaspareit, J ...... 2167* Khang, H ...... 2064 Jespers, A ...... 1626 Joslin, D ...... 1684 Kasten-Jolly, J ...... 327 Khaphalia, B S ...... 1720 Jessen, B ...... 631, 1669 Josset, P ...... 847 Kastrati, I ...... 2163* Kho, Y ...... 1400 Jester, E l ...... 1429 Jovanovic, M L ...... 811* Katagiri, H ...... 2442 Kiebler, Z ...... 494 Jesus, E ...... 2061 Joyner, D R ...... 2117 Katein, A ...... 1857 Kiechle, M ...... 538 Jett, M ...... 1085 Ju, C ...... 1124* Kato, M ...... 527 Kieswetter, K ...... 1691 Jewell, W T ...... 2111 Judah, D J ...... 796 Katoh, K ...... 204 Kijtawornrat, A ...... 1529* Jia, L ...... 595* Judo, M ...... 182 Katsifis, S P ...... 544 Kiker, G ...... 1639 Jia, N ...... 2109 Jun, G ...... 557 Kauffman, F ...... 899 Kikkawa, H ...... 636 Jia, Z ...... 483, 1214* Jun, I ...... 247, 682, 684*, 1817 Kauffmann, H ...... 522, 2324 Kil MD, J ...... 1297 Jiang, B ...... 310* Jun, Y ...... 1938 Kaufman, J D ...... 234 Kilgore, M W ...... 305 Jiang, G ...... 520* Jung, C T ...... 810 Kaufman, S ...... 172 Kilgour, J ...... 1231 Jiang, G C ...... 1786* Jung, E ...... 2396 Kaufmann, W ...... 48, 1432 Kille, P ...... 1087 Jiang, J ...... 2002*, 2003, 2005 Jung, R ...... 1634, 2324* Kaur, P ...... 1780* Kilroy, C ...... 1684 Jiang, S ...... 1020 Junker, K ...... 1047 Kause, J ...... 2205, 2320 Kilty, C ...... 457 Jiang, W ...... 1646, 1811, 1812, 1818* Kavanagh, T ...... 992, 1472, 2006 Kilty, C G ...... 534* Jiang, Y ...... 190, 191, 1379, Kavanagh, T J ...... 229, 234, 488, 507 Kim, A S ...... 116* ...... 1767*, 2152 K Kavlock, R ...... 2337 Kim, C ...... 605, 2064 Jianlin, L ...... 1259 Kabilan, S ...... 35 Kavlock, R J ...... 1128, 1129* Kim, C H ...... 2410 Jiliang, H ...... 1259* Kabirov, K K ...... 946* Kawabata, T ...... 619, 1748 Kim, D ...... 162, 677*, 683, 839*, Jimenez, B D ...... 1341 Kadambi, V ...... 757 Kawabata, T T ...... 1737 ...... 965, 1049, 1216, 1371, Jimenez, I ...... 1798 Kadambi, V J ...... 2422, 2423 Kawabe, M ...... 1423 ...... 1393, 1403, 1407, 1408*, Jin, B ...... 1738 Kadokura, H ...... 1316, 1670 Kawai, R ...... 2272 ...... 1409, 1410, 1413, 1959 Jin, C ...... 247, 682, 684, 1817* Kadota, T ...... 1614 Kawakami, T ...... 83* Kim, D H ...... 885 Jin, G ...... 265 Kadowaki, T ...... 2442 Kawamoto, T ...... 193, 676, 693, Kim, D W ...... 1752 Jin, H ...... 1017, 1018* Kadry, A M ...... 2205*, 2320* ...... 798, 868*, 2269 Kim, E ...... 445, 791 Jin, J ...... 1374 Kaefferlein, H ...... 1252 Kawanishi, M ...... 790 Kim, G ...... 247, 682*, 684, 1817 Jin, Q ...... 581, 605 Kaempfe, T A ...... 2336 Kayama, F ...... 865*, 1023, 2031 Kim, H ...... 269*, 572, 1076, Jin, X ...... 244, 1196, 1197 Kaetzel, R S ...... 1258*, 2201 Kaydos, E ...... 1166 ...... 1076, 1216, 1339, 1345*, Jindo, T ...... 458 Kagan, V ...... 2005 Ke, H ...... 2027 ...... 1359, 1393, 1403*, 1403*, Jirtle, R ...... 1860* Kagan, V E ...... 12, 15*, 1158, Ke, S ...... 1322, 1330 ...... 1409, 1411, 1518, 1658* Jirtle, r ...... 1864* ...... 1163, 1556, 1557, Kearney, M ...... 804 Kim, H G ...... 86, 1350* Jo, W J ...... 2051* ...... 2002, 2003, 2004 Kedderis, G L ...... 1274, 2144 Kim, H J ...... 1431, 2365 Jo, Y ...... 269 Kahl, M D ...... 1565 Keeler, G J ...... 2213 Kim, I ...... 1938 Joachim, F J ...... 1626 Kai, M ...... 925, 2100 Keen, C ...... 934 Kim, J ...... 85, 269, 269, 401, 581, Johansen, M E ...... 1164 Kailasam, S ...... 1517 Keenan, J J ...... 1249* ...... 1049, 1076, 1216*, 1371, Johanson, G ...... 1623*, 2303, 2382 Kale, V M ...... 681* Keene, B ...... 1529 ...... 1393, 1400, 1403, 1407, Johansson, E ...... 504* Kalefi, T ...... 2178 Keener, M ...... 198 ...... 1408, 1409, 1411, 1412, Johansson, N ...... 1456, 1458*, 2052 Kalgutkar, A ...... 2138 Keep, R F ...... 1103 ...... 1794, 1813, 2053, 2334, 2334 John-Baptiste, A ...... 2343* Kallman, M J ...... 736, 739* Kehl, M ...... 1291 Kim, J H ...... 1959 Johns, T ...... 1391 Kalluri, R ...... 469 Keil, D ...... 256, 288*, 571 Kim, J Y ...... 86, 1218, 1410 Johnson, A ...... 125, 1663 Kalmes, M ...... 211 Keita, K ...... 972 Kim, K ...... 209, 358, 572*, Johnson, A M ...... 1667 Kaltenhaeuser, J ...... 142* Kelleher, C ...... 1924 ...... 1431, 1450, 1452*, 2365 Johnson, B ...... 364 Kaluzhny, Y ...... 319, 1593 Keller, A ...... 1883 Kim, K H ...... 923 Johnson, B R ...... 2349 Kamal, M A ...... 1045 Keller, N P ...... 1994 Kim, K Y ...... 1752, 1959 Johnson, D A ...... 2415 Kamata, E ...... 130 Kelley, T ...... 1857 Kim, M ...... 530*, 1389 Johnson, D J ...... 1211 Kamendulis, L M ...... 955, 1125* Kellner, T P ...... 2290 Kim, N ...... 1366 Johnson, E W ...... 1056, 1241* Kamenosono, T ...... 615 Kelly, D P ...... 1055 Kim, S ...... 401*, 450, 450, Johnson, F O ...... 1445* Kaminski, N ...... 1041 Kelman, B J ...... 2314 ...... 702, 885*, 1230, 1389, Johnson, J ...... 1194, 1305, 2174 Kaminski, N E ...... 266, 1729, 1732 Kelsh, M ...... 848 ...... 1794, 1794, 2420 Johnson, J A ...... 2415 Kamischke, A ...... 2105 Kelsh, M A ...... 2184 Kim, S K ...... 671* Johnson, J D ...... 801, 2352, 2363 Kammueller, M ...... 788 Kemmerer, M ...... 789 Kim, S S ...... 885 Johnson, J E ...... 1790, 1791 Kan, H ...... 1084 Kemper, R A ...... 2115* Kim, T ...... 308*, 1938 Johnson, J M ...... 856 Kanazashi, S ...... 1094 Kendall, L ...... 580 Kim, Y ...... 639, 640*, 672, 1513 Johnson, K ...... 364, 1238*, Kanbori, M ...... 206 Kendall, R J ...... 176 Kim, Y B ...... 1690 ...... 1426*, 2174, 2323 Kaneko, S ...... 204 Kendig, D M ...... 487* Kim, Y W ...... 1959 Johnson, K A ...... 2331 Kaneko, T ...... 577 Kenna, G ...... 2135 Kim, j ...... 1794 Johnson, K W ...... 2416 Kang, C ...... 2211 Kennedy, A ...... 1564 Kimbell, J ...... 9 Johnson, M ...... 625 Kang, G ...... 2068 Kennedy, G L ...... 2325 Kimbell, J S ...... 35, 1885, 2117, 2125 Johnson, N H ...... 1664* Kang, H ...... 273, 791, 1938, 2268 Kennedy, I M ...... 1026 Kimber, I ...... 376, 377, 378, 770*, 953, Johnson, P T ...... 364 Kang, I ...... 1938 Kennedy, J ...... 378 ...... 1140, 1145, 1222, 1836*, Johnson, R E ...... 183, 1661 Kang, J ...... 401, 1228, 1339*, 1359* Kennel, P ...... 2254 ...... 1837*, 1840, 1841, 1931, Johnson, S ...... 1448 Kang, K ...... 64, 1230*, 1389* Kennett, M J ...... 207 ...... 2254*, 2255, 2259, 2260, Johnson, V J ...... 1499* Kang, T ...... 1938* Kensler, T ...... 17 ...... 2261, 2264, 2273, 2277 Johnson, W D ...... 1674, 1982*, 1983 Kang, W ...... 581 Kensler, T W ...... 20*, 502, 1348 Kimmel, E ...... 1033, 1034 Johnston, L C ...... 1098, 1107 Kang, Y ...... 642, 1049, Kent, M ...... 849 Kimmel, E C ...... 1031, 1032*
266 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Kimura, K ...... 1530 Koda, T ...... 1421 Krone, P H ...... 147 Lamm, S H ...... 869* Kimura, T ...... 2272 Kodama, Y ...... 978 Krowech, G ...... 899 Lammers, J ...... 48, 2381 Kinaga, T ...... 193, 676, 693, Kodavanti, P R ...... 2411* Krueger, M ...... 34 Lamore, S ...... 396 ...... 798, 868, 2269 Kodavanti, U P ...... 240, 1062*, 1063, Kruhlak, N L ...... 1133 Lampertsdoerfer, T ...... 447 Kinboshi, M ...... 104, 105 ...... 1194, 2173, 2411 Kruse, S ...... 1109 Lamy, E ...... 551* Kincaid, A ...... 1420 Koehl, R ...... 471 Krysiak, B ...... 703 Lan, C ...... 1757 Kind, J A ...... 2192 Koga, T ...... 1309*, 1316 Krysiak, O ...... 703 Lan, Q ...... 526 King, M A ...... 2433 Koganti, A ...... 1540, 1541 Ku, H ...... 273, 791, 2268* Landenberger, B ...... 1631 King Heiden, T ...... 394* Koh, W S ...... 1690* Ku, W W ...... 1130 Landgren, C A ...... 272* Kiningham, K ...... 1009 Kohara, A ...... 2140 Kubik, R ...... 2138 Landolph, J R ...... 2085* Kinoshita, A ...... 1228 Kohli, A R ...... 78 Kubilus, J ...... 44, 319, 396, Landthaler, M ...... 822 Kinoshita, M ...... 636, 2166 Kohrman, K A ...... 1260 ...... 1591, 1593 Lane, J ...... 757, 2423 Kinsella, T ...... 2363 Kohut, M ...... 272 Kubota, R ...... 1213 Lane, N L ...... 427 Kinsey, G R ...... 456* Kohute, C R ...... 1586 Kuehl, C J ...... 2073* Lang, W ...... 985, 996* Kinslow, C ...... 797* Koivunen, M ...... 1518, 1936 Kuempel, E ...... 347 Langer, C ...... 580 Kinslow, C J ...... 701 Koizumi, A ...... 104, 105, 106, Kuempel, E D ...... 349* Langston, W J ...... 1107 Kinter, L B ...... 2243 ...... 107, 108, 2435 Kuester, R ...... 2149* Lanham, D ...... 1745 Kinzell, J H ...... 2322 Kojima, C ...... 411 Kuester, R K ...... 592, 593 Lanning, L L ...... 1704 Kirby, P J ...... 1029, 1053* Kolaja, K ...... 182, 987, 1907, 2392 Kuhl, A ...... 1364* Lanosa, M ...... 1030 Kirillov, E ...... 668 Kolaja, K L ...... 169 Kuhl, P ...... 309 Lansita, J A ...... 132* Kirk, C A ...... 558*, 2278 Kolanczyk, R ...... 2295 Kulas, J ...... 2199 Lantum, H M ...... 523, 1977 Kirk, R ...... 1197 Kolanz, M ...... 849 Kulkarni, G S ...... 806*, 1038 Lantvit, D D ...... 1645 Kirk, S A ...... 1739 Kolvek, B ...... 2099 Kulkarni, S ...... 2138 Lantz, R ...... 422, 437, 2074* Kirkpatrick, D T ...... 1232, 1239, 1696 Komiyama, M ...... 1614, 1952, Kullman, S ...... 1955 Lantz, R C ...... 2073, 2349 Kirlin, W G ...... 674 ...... 1987, 2110 Kultima, K ...... 368 Lanyon, R ...... 1610 AUTHOR INDEX Kirman, C R ...... 463 Kommineni, C ...... 846 Kumagai, K ...... 2272 Lapczynski, L ...... 1296, 1298 Kirsch, G ...... 655 Kondo, T ...... 119 Kumagai, Y ...... 480 Lapets, O ...... 511, 1960 Kirsch, G E ...... 663, 665 Kondraganti, S ...... 1811 Kummeneje, E ...... 2066 Lapin, C ...... 860 Kirschten, N ...... 2350 Kondraganti, S R ...... 1646*, 1818 Kunugita, N ...... 676 Lapointe, J ...... 620, 1744 Kishi, R ...... 119 Konduru, N V ...... 1163 Kuper, F ...... 373, 1047 Lappin, P B ...... 308, 625, 1740, 1741 Kisin, E ...... 846, 1556*, 1557 Konig, B ...... 822 Kurahashi, N ...... 119 LaPres, J ...... 2034 Kissling, G ...... 546, 1831 Konig, R ...... 2405* Kuramoto, S ...... 1530 Larange, A ...... 1734 Kissling, G E ...... 2101 Kono, M ...... 108 Kurata, M ...... 1315* Lariviere, R ...... 1944 Kitagawa, K ...... 693, 798 Konsolaki, M ...... 1781 Kurnikov, I V ...... 1158, 2004 Larkin, P ...... 1584 Kitamura, Y ...... 978 Konsoula, R ...... 1973* Kuroiwa, Y ...... 972, 978*, 2134 LaRochelle, A ...... 1683 Kitazima, T ...... 206 Koo, E ...... 293* Kurose, K ...... 1333 Larsen, G ...... 2332* Kitchin, K ...... 54 Koos, R D ...... 392 Kuryshev, Y ...... 666 Larsen, L ...... 60 Kito, G ...... 667, 1316, 2154 Kopf, P G ...... 2170, 2171* Kuryshev, Y A ...... 659, 663* Lascu, S ...... 1532 Kiyosawa, N ...... 186*, 206 Koppelman, S J ...... 2253 Kusaka, Y ...... 107 Lash, L H ...... 460* Klaassen, C ...... 1988 Koppikar, A ...... 347, 347, 348* Kushida, H ...... 2166 Laskin, D L ...... 481, 1007, Klaassen, C D ...... 10*, 202, 564, Korashy, H M ...... 2079* Kushida, M ...... 1228* ...... 1064*, 1706 ...... 1334, 1349, Korb, S ...... 1296, 1298 Kusnecov, A ...... 1115 Laskin, J D ...... 481, 831, 1007, ...... 1361, 1363, 2147 Korrapati, M C ...... 688 Kuszak, J ...... 366 ...... 1064, 1188, 1706 Klabunde, K J ...... 2202 Korrapati, M C ...... 452* Kuwabara, Y ...... 882* Laskin, O ...... 133 Klaunig, J E ...... 331*, 955, 1122*, 1125 Korsch, M ...... 2065 Kuwagata, M ...... 1427, 1460* Lasky, R E ...... 1453 Klausner, M ...... 44, 319, 396, Korte, H ...... 2335 Kuwano, K ...... 2154 Lasley, B ...... 1567 ...... 1591, 1593 Korte, J ...... 1941 Kuykendall, J R ...... 1264, 1265, Lasley, B L ...... 2384 Kledal, T ...... 131 Korte, J J ...... 1572, 1573, 1942* ...... 1266, 1267 Lasley, S M ...... 338, 1789* Kleeberger, S R ...... 1029, 1067, 1502* Korte, L M ...... 1572, 1573, 1942 Kuznetsov, A ...... 2344 Lassen, N ...... 366*, 468 Klei, L R ...... 441, 2047 Korte, S H ...... 1311* Kwack, S ...... 401 Last, J A ...... 1068 Kleiner, H E ...... 1883* Korwel, I ...... 588* Kwanyuen, P ...... 1089 Latchoumycandane, C ...... 1712* Kleinert, K ...... 2323 Kosaka, N ...... 2279, 2281, 2282 Kwekel, J ...... 985 Latendresse, J R ...... 452, 459, Kleinjans, J C ...... 2218* Kosemund, K ...... 1260 Kwekel, J C ...... 227, 398*, 403 ...... 467, 1008, Kleinman, M ...... 246 Kosian, P ...... 1941 Kwok, R ...... 408 ...... 1943*, 2157, 2304 Kleinman, M T ...... 2175* Kosian, P A ...... 1942 Kwon, J ...... 1049* Latendresse, J ...... 2146 Kliewer, S A ...... 1321 Kostrubsky, V ...... 1004, 2138* Kwon, Y D ...... 1690 Lathall, A ...... 587 Klingler, K E ...... 2410 Kostyniak, P J ...... 1207, 2436 Latriano, L ...... 133 Klintworth, H ...... 1109 Kosyk, O ...... 1225 Lau, C ...... 370, 576*, 932, 937, 2337 Kluetzman, K ...... 1833 Kotha, L ...... 951* L Lau, C S ...... 369 Knaak, J B ...... 1207, 1219 Kotick, J ...... 1800 La, H ...... 844 Lau, S S ...... 174, 483, 574, 1381, 2122 Knadle, S ...... 110 Kouadio, J H ...... 1387, 1388 La Du, J K ...... 1210 Laudermilch, C ...... 136* Knadle, S A ...... 729 Kouadio, K ...... 2263 La Merrrill, M ...... 316 Laudermilch, C L ...... 137 Knapp, G ...... 53 Kouppari, A K ...... 2293 Labashinsky-Heinrich, E ...... 528 Lauer, F T ...... 264 Knapp, J F ...... 936*, 1236 Koutrakis, P ...... 2211 Labenski, M T ...... 2122 LaVire, H ...... 673 Knapton, A ...... 125, 295, 1665 Koyano, S ...... 1333 Labhart, P ...... 1071 Law, B F ...... 379 Knapton, A D ...... 296* Koza-Taylor, P ...... 294 Lacasse, E ...... 633 Lawlor, T E ...... 547 Knaup, W ...... 1634 Koza-Taylor, P H ...... 200 Lacerda, A E ...... 659* Lawn, D ...... 959 Knecht, K T ...... 1419*, 2410* Krajnc-Franken, M ...... 997 Lacher, S E ...... 1828* Lawrence, B ...... 257, 258, 1552*, 1898 Knecht, M M ...... 1419 Kramer, J ...... 655* Lacour, S ...... 1894* Lawrence, D A ...... 327*, 1100 Knight, A ...... 1582* Kramer, J W ...... 659 Ladd, W ...... 1859 Lawrence, J W ...... 2133 Knight, B ...... 462 Kramer, P ...... 598 Ladics, G ...... 2239* Lawrence, P B ...... 277 Knipp, G T ...... 362, 919 Kramer-Stickland, K ...... 250, 308 Ladics, G S ...... 769* Lawrence, W B ...... 1244 Knippels, L M ...... 2253* Krance, S M ...... 941*, 1161 LaDu, J K ...... 1120 Laws, S ...... 1932, 1946*, 1948 Knobloch, T J ...... 1648 Kransler, K M ...... 95* Lafferty, J S ...... 649* Laws, S C ...... 1566 Knochel, J ...... 1240, 2328 Krantis, A ...... 1975* Lahousse, S ...... 1238 Lawson, D ...... 860 Knoerr-Wittmann, C ...... 1347 Krantz, Q T ...... 2430 Lahsaei, P ...... 1791 Lawton, M ...... 994, 1744, 1859 Knudsen, G A ...... 592* Krauthauser, C L ...... 72 Lainee, P ...... 1317 Lawton, M P ...... 200, 294 Knutsen, J ...... 851, 1254 Kremer, J ...... 1270 Lake, S ...... 1702 Layer, J ...... 651 Ko, J ...... 1794 Kretschmer, X C ...... 1327, 1830 Lakeram, M ...... 690* Lazennec, G ...... 777 Kobayashi, K ...... 1091, 1451, 1530 Krieger, R I ...... 1249 Lalko, J ...... 813, 2271* Le, T ...... 1962, 1963 Kobayashi, M ...... 1378 Krieger, S M ...... 1052 Lalli, E ...... 1324 Le, X C ...... 975 Kobayashi, T ...... 1378, 1749 Krieter, P A ...... 935 Lalonde, G ...... 1037 Le Nedelec, M J ...... 60 Kobayashi-Hattori, K ...... 275 Krishna, C ...... 1968, 1970 Lam, K ...... 560 Lea, I ...... 967 Kocerha, R J ...... 1352 Krishnamohan, M ...... 2086* Lamar, P C ...... 449, 1663, 2022 Leach, A C ...... 1700 Koch, M ...... 242 Krishnamoorthy, R ...... 617 Lamb, J C ...... 1235 leach, G ...... 1622* Koch, W H ...... 2329* Krishnan, K ...... 565, 893*, Lamb, J G ...... 1650 Leach, G J ...... 2069 Kochanek, P ...... 2005 ...... 916, 1273, Lamberson, W R ...... 1405 Leakey, J E ...... 1655, 1717 Kochar, J ...... 1108 ...... 1609, 2366, 2382 Lambert, J C ...... 2197* Lear, A M ...... 1241 Kochar, J K ...... 1488 Krishnaraj, R ...... 601* Lambright, C ...... 1168, 1233* Learn, D B ...... 818*, 819, 2087 Koda, S ...... 107 Kristovich, R L ...... 1031, 1032, 1033* Lambright, C R ...... 1545 Leavens, T ...... 1272* up-to-date information at www.toxicology.org 267 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Leazer, T ...... 402 Leslie, H ...... 2345* Lingenfelter, R A ...... 525, 1250* Lu, B ...... 994* Lebetkin, E H ...... 100*, 1878, 2371 Letizia, C ...... 938* Linger, A ...... 1036 Lubet, R A ...... 1676 LeBlanc, G A ...... 1953 Letzkus, M ...... 141 Lingle, W L ...... 519 Lucas, A ...... 2339 Leblond, N ...... 1531 Leuillet, S ...... 1074, 2397 Linkov, I ...... 1639* Lucas, F ...... 1305 Lebrun, S ...... 309* Leung, H ...... 561*, 570, 1536 Linney, E ...... 1876 Lucas, S ...... 76 Lechuga, D ...... 1037 Levant, B ...... 1988 Linnum, A L ...... 1565 Lucchini, R ...... 188 LeClaire, R D ...... 1921 Leverette, R D ...... 531*, 557, Linsley, P S ...... 201 Luchtel, D L ...... 234 Lecoeuche, D ...... 1734 ...... 1721, 2338 Liou, J ...... 2412* Lucock, A ...... 1313* LeCureux, L W ...... 2147* Levesque, P C ...... 662 Lipinski, R J ...... 128* Luderer, U ...... 1549 Ledbetter, A D ...... 233, 1062, Levin, A A ...... 250, 292, Lippmann, M ...... 1195, 1197 Ludewig, G ...... 1542
AUTHOR INDEX AUTHOR ...... 1063, 1194, 1698 ...... 308, 455, 602 Lipscomb, J C ...... 1274, 2197, Ludlow, J W ...... 2144 Ledesma, J B ...... 817 Levin, B C ...... 795* ...... 2289*, 2383 Luebke, A E ...... 1449 Ledoux, T ...... 1571 Levin, E ...... 2232, 2236* Lipsky, M M ...... 448 Luebke, B ...... 255* Lee, C ...... 415, 797, 2249 Levin, E D ...... 609, 1439 Lisek, R ...... 1802 Luebke, R ...... 1897 Lee, D ...... 247, 682, Levine, A M ...... 2077 Lisowski, A R ...... 1114 Lujan-Galvan, V ...... 112, 280 ...... 683, 684, 1817 Lewandowski, T A ...... 2195, 2341* Liston, V ...... 101, 102 Lulham, G ...... 230, 1965* Lee, D W ...... 2436* Lewis, C ...... 2291 Litterman, A ...... 1783 Lulla, A ...... 1344* Lee, E ...... 247, 672, 677, Lewis, C M ...... 2290* Little, S B ...... 1887 Lum, R ...... 993 ...... 683, 905, 1813 Lewis, D A ...... 1666 Liu, C ...... 620 Lumley, L A ...... 68, 78* Lee, E Y ...... 1221 Lewis, D L ...... 201 Liu, F ...... 1191* Lumpkin, M H ...... 1274* Lee, F W ...... 1655* Lewis, E ...... 942 Liu, F F ...... 1255 Lund, A K ...... 355*, 779, 2171 Lee, G ...... 1548 Lewis, E M ...... 933, 938 Liu, G ...... 1520 Lund, K C ...... 2155* Lee, H ...... 605, 923, 1690, 2420 Lewis, J ...... 1121 Liu, J ...... 58, 343, 431, Lundback, S S ...... 82 Lee, J ...... 269, 581, 605*, Lewis, K ...... 844 ...... 1473, 1474*, 1663, Lundberg, M ...... 48 ...... 1049, 1185, 1230, Lewis, L M ...... 867 ...... 2022, 2026*, 2040 Lundberg, R ...... 89*, 1574, 1575* ...... 1325*, 1966, 2053, 2064 Lewis, S M ...... 1655 Liu, L ...... 860 Lundebye, A ...... 1998 Lee, J S ...... 1752 LI, A P ...... 1957* Liu, M ...... 2159 Lundquist, R B ...... 1066 Lee, K ...... 80, 580, 1409, Li, D ...... 662 Liu, Q ...... 293, 988*, 1389 Lunec, J ...... 2083 ...... 1411, 1412, 2018* Li, G ...... 526, 577 Liu, S ...... 209*, 358, 1157 Lunstra, D ...... 2096 Lee, K J ...... 2440* Li, H ...... 185, 246 Liu, W ...... 1759 Luo, F ...... 547 Lee, K M ...... 183, 230, 1661* Li, J ...... 1966, 2415, 2434 Liu, X ...... 1760, 2401 Luo, H ...... 957 Lee, K P ...... 1055 Li, K L ...... 2330 Liu, k ...... 435 Lurie, D I ...... 1797 Lee, K Y ...... 1356 Li, L ...... 899, 981, 1176 Liu Ph.D, J ...... 1297 Luross, J ...... 286* Lee, M ...... 987, 2165 Li, M ...... 261*, 999, 1990 Livanos, E ...... 546, 1291 Lusiak, B D ...... 2352* Lee, M K ...... 1090 Li, N M ...... 1957 Llados, F ...... 892 Lusis, J ...... 1548 Lee, P ...... 1185 LI, Q ...... 1195*, 1196, 1197, 1645 Lnenickova, Z ...... 1257 Luster, M I ...... 1497*, 1499, 1555 Lee, R ...... 401, 1222, 1968, 1970 Li, T ...... 2375* Lo, W ...... 954 Lustofin, K ...... 153* Lee, S ...... 247, 672*, 682, 683, Li, W ...... 641, 1365, 2028, 2434 Lobenhofer, E K ...... 2132 Luyendyk, J P ...... 1002, 1708, 1710*, ...... 684, 684, 1803*, 1817 Li, X ...... 191 Locey, B J ...... 583, 585 ...... 1711, 1905, 2148 Lee, T ...... 1717 Li, Z ...... 1251, 1251 Loch Caruso, R ...... 1553 Lynch, B S ...... 1638, 2335 Lee, W ...... 1292* Li, Z J ...... 1555* Lochry, E ...... 253 Lynch Ph.D, E ...... 1297 Lee, Y ...... 1185*, 1468, 1469* Lia, F ...... 1767 Lock, E A ...... 452, 467 Lynes, M ...... 265* Lee, Y J ...... 1690 Liang, L ...... 1101 Lockley, D J ...... 690 Lyon, J J ...... 512 LeFevre, S ...... 115* Liang, Y ...... 1037 Lodge, J ...... 568* Lyubimov, A ...... 601, 1677 Lefkowitz, L ...... 2350 Liao, G ...... 548 Loehr, C ...... 1656 Lyubimov, A V ...... 946 Legare, M E ...... 1097 Liao, K H ...... 1271, 1875, Logan, T P ...... 81 Legay, F ...... 788 ...... 1886, 2310* Logue, B A ...... 1918 Legler, J ...... 384 Liao, W ...... 436 Loguinov, A ...... 786 M Lehman-McKeeman, L ...... 1334, Liao, X ...... 159, 1548 Loguinov, A V ...... 1564 Ma, J K ...... 479 ...... 2221* Lichtensteiger, W ...... 1928* Lohitnavy, M ...... 1278, 2123 Ma, J Y ...... 479* Lehman-McKeeman, L D ...... 1710, Lickteig, A ...... 2400* Lohitnavy, O ...... 2123 Ma, L ...... 365 ...... 2147, Liebler, D C ...... 509, 1016, 2011 Lomax, L ...... 804 Ma, M ...... 119* ...... 2227, 2228 Lieder, P ...... 603, 1234, 2327* Lombard, C A ...... 1162* Ma, N ...... 174 LehmanMcKeeman, L D ...... 161 Liesivuori, J ...... 1623 Long, C M ...... 2305 Ma, Q ...... 2046 Lehmann, G M ...... 420* Lieuallen, W ...... 2174 Long, J P ...... 1921 Ma, Y ...... 1558* Lehmler, H ...... 588, 1221 Lifen, J ...... 1259 Long, K E ...... 1625 Maatta, J ...... 372 Lehner, A F ...... 1406 Liguori, A ...... 437 Long, L ...... 191 Macalady, D L ...... 814 Lehto, M ...... 372 Liguori, M J ...... 1708, 1711, 1905* Long, T ...... 513* MacDonald, J ...... 2094 Lei, X ...... 1988 Lilienthal, H ...... 384 Longstreth, J ...... 2312 MacDonald, J M ...... 2093, 2144 Leibold, E ...... 586 Lim, C ...... 874, 927* Lonning, S ...... 633 MacDougald, O ...... 2232, 2233* Leighton, J K ...... 2 Lim, D ...... 1409* LoPachin, R M ...... 2421, 2427 MacGregor, J A ...... 383 Leikauf, G D ...... 87, 504 Lim, E ...... 91 Lopez Carrillo, L ...... 863 MacNair, D ...... 876* Leikin, J B ...... 1625 Lim, F ...... 953*, 1222, 1931 Lopez-Gonzalez, L M ...... 1822 MacPhail, R C ...... 1491*, 2411 Lein, P ...... 1441*, 1450 Lim, H ...... 605 Lord, J L ...... 483* MacPherson Ph.D, B ...... 1297 Leininger, J R ...... 2330 Lim, J ...... 920 Lord, P ...... 789 Maczka, C ...... 2205 Leino, M ...... 372 Lim, K ...... 401, 500, 2054 Lordo, R ...... 2176 Maddaloni, M ...... 347, 347 Leinweber, B ...... 174* Lim, L ...... 2292* Loson, O ...... 94 Maddaloni, M A ...... 352* Leinweber, B L ...... 2351 Limon, J H ...... 1769* Lotti, M ...... 1465 Maddelena, R ...... 1255 Leisy, A E ...... 304 Limpach, A ...... 1420 Lotz, K ...... 447 Madden, M C ...... 235, 635, 746*, 751, Leiter, K ...... 1914 Lin, A ...... 294 Louden, C ...... 2168 1180 Leith, D ...... 1702 Lin, C ...... 92, 93*, 160* Louden, C S ...... 1857* Maddox, J ...... 1496 Leitner, H ...... 1714* Lin, G ...... 2046 Lough, J ...... 143, 144 Maddox, J F ...... 1002, 1005, 1708, Leiva Presa, A ...... 1574 Lin, J A ...... 1999 Loughran, T P ...... 889 ...... 1710, 1711, 1718, 1905 Leko, N ...... 554 Lin, L ...... 94, 802 Louie, H ...... 2065 Madejczyk, M S ...... 2067* Lemanissier, M ...... 1532 Lin, P ...... 92*, 93, 436, 954* Loveless, K ...... 1786 Madhukar, B V ...... 1021* Lemasters, J J ...... 1003, 1715* Lin, Q ...... 2427 Loveless, S E ...... 2325* Madl, A ...... 848, 849* Lemos, M ...... 2211 Lin, T ...... 921, 922* Lovik, M ...... 878* Madren-Whalley, J ...... 1968, 1970 Lencinas, A ...... 2048* Lin, W ...... 1558 Lowit, A ...... 46, 2284* Maduabuchi, J M ...... 1995 Leng, G ...... 1249 Lin, X ...... 952* Lowit, A B ...... 1478, 2285 Maekawa, A ...... 1652 Lentz, S E ...... 694 Lin, Y ...... 39, 346, Lowney, Y ...... 409* Maekawa, M ...... 925 Leon-Chavez, B ...... 2032 ...... 1520, 1535, 1660 Lowney, Y W ...... 410, 1258, Maerkel, K ...... 1928 Leonard, R C ...... 1275 Linak, W ...... 236, 249 ...... 2188, 2190 Magness, S ...... 947 Leonard, S ...... 1046 Linak, W P ...... 707 Lowry, G V ...... 513 Magotani, H ...... 2154 Leonard, S S ...... 543 Lind, M ...... 89 Lowry, K ...... 1386 Mahadevan, B ...... 38*, 55, 1816 LePage, K T ...... 1429* Lind, M P ...... 88, 1575 Lu, B ...... 294 Mahagita, C ...... 2131* Lepoittevin, J ...... 1590 Lind, P ...... 1574* Lu, G ...... 65* Mahammad, R B ...... 340 Leppert, S ...... 2193 Linden, J ...... 84 Lu, H ...... 564, 1988* Maher, J ...... 564, 1334 LeSauteur, L ...... 1739, 1748 Lindon, J C ...... 161 Lu, I ...... 984 Maher, J M ...... 202, 1349, 1361 Leseman, D ...... 1193, 1198 Lindsay, D ...... 1924 Lu, M ...... 975 Mahl, J A ...... 788 Leslie, E M ...... 1672 Ling, G ...... 1833 Lu, Y ...... 539*, 1019, 1278, 2123* Maier, A ...... 890*, 917
268 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Maier, C ...... 2256* Martinez-Levy, G ...... 2061, 2075 McDaniel, K L ...... 1799 Mense, S M ...... 1757* Maier, R M ...... 2078 Martini, B D ...... 1370 McDermott, T ...... 631 Mensing, T ...... 1252 Maier, W E ...... 1678 Martino-Catt, S ...... 80 McDiarmid, M ...... 2071, 2072* Menzie, A ...... 201 Mailman, R B ...... 1374 Marty, M ...... 727* McDonagh, P ...... 2150 Menzies, A R ...... 60 Maisch, T ...... 822 Marty, M A ...... 2185 McDonald, J ...... 241*, 566, 2212* Mercado Feliciano, M ...... 1934* Majeska, J B ...... 2115 Marty, M S ...... 1248* McDonald, J D ...... 1201 Mercer, R ...... 1557 Majkova, Z ...... 91*, 305 Marvanova, M ...... 1843 McDonald, T ...... 1250, 2182, 2307 Merchant, H ...... 1798 Major, M A ...... 2366* Mascarenhas, R A ...... 1626 McDonald, T A ...... 2322 Merle, H ...... 847 Maki, A ...... 162, 194 Maserek-Ruud, W ...... 1918* McDonald, T B ...... 2296 Merrick, B ...... 1104 Makin, A ...... 131* Mash, D ...... 1086 McDonald, T J ...... 525, 1251 Merrick, B A ...... 1081 Makoto, N ...... 140* Mash, E A ...... 424, 425, 427 McDonough, J H ...... 68 Merrill, E A ...... 1279, 2367 Makris, S ...... 1425 Masoka, X ...... 533 McDougal, J N ...... 836*, 837, Merriman, T ...... 844 Makris, S L ...... 1428* Mason, A M ...... 1271* ...... 838, 2118 Mersch-Sundermann, V H ...... 516*, Makynen, E A ...... 1565 Mason, R ...... 620 McEwen, A B ...... 587, 1589* ...... 551 Malamant, M ...... 2343 Mason, S ...... 650, 661, 1308* McGarrigle, B P ...... 1207 Merten, K ...... 2152 Malarkey, D ...... 2174 Mason, s ...... 651 McGaughy, R ...... 2302 Merten, K E ...... 1379* Malarkey, D E ...... 329* Massey, T E ...... 542, 643, 644, 1649 McGee, J K ...... 1698 Mertz, L ...... 988 Malek, N A ...... 871* Massulik, S ...... 1636 McGinnis, P ...... 1636, 1926 Mervis, R F ...... 1800* Mally, A ...... 506, 963* Masubuchi, N ...... 1621* McGlothan, J L ...... 1846 Messer, D C ...... 594 Manabe, S ...... 206, 2272 Matei, A ...... 1160 McGovern, T ...... 735* Metcalf, C D ...... 2246* Manak, M ...... 1307 Matherly, C ...... 1930 McGrath, P ...... 39, 1535 Metry, K J ...... 800* Manauto, J E ...... 1321 Mathew, L K ...... 222*, 223 McGraw, J E ...... 686* Metzdorff, S B ...... 1945 Manautou, J E ...... 200, 202*, Mathias, R L ...... 594 McGregor, W ...... 800 Metzler, M ...... 675 ...... 563, 1001, Mathieu, L ...... 847*, 1587 McGuinn, W ...... 571* Meyer, K ...... 134 ...... 1006, 1367, 2400 Mathrani, V C ...... 1068* McGuire, J ...... 71* Meyer, S A ...... 681 AUTHOR INDEX Manca, D ...... 913, 1269 Matson, J ...... 602 McGuire, J M ...... 68, 70, 77 Meyerhoff, R D ...... 880 Mancebo, A M ...... 1911, 1912* Matson, K ...... 80 McKay, C ...... 1903 Meza-Velazquez, R ...... 280 Mandlekar, S V ...... 662 Matsubara, E ...... 104*, 105, 106* McKee, C M ...... 2019* Michael, D ...... 356 Manetz, S ...... 2091 Matsui, K ...... 1326 McKinney, P ...... 1528 Michaelidou, S C ...... 2293 Mangialaio, S ...... 2141 Matsumoto, M ...... 130 McLanahan, E ...... 2386 Michel, A ...... 1745 Manibusan, M K ...... 2300* Matsumura, F ...... 777, 950, 1539 McLaughlin, B ...... 1786 Michel, C ...... 1223* Maniratanachote, R ...... 204 Matsuno, K ...... 798 McLellan, C J ...... 886, 1613 Michelizza, S ...... 1024 Manivasakam, P ...... 538 Matsuno, Y ...... 1614 McMahon, J ...... 2328 Mickle, B ...... 2402 Manley, A ...... 383 Matsuo, J ...... 667 McMahon, J M ...... 811 Mielke, H ...... 2060* Mann, K K ...... 419* Matsushita, T ...... 1091 McMahon, N ...... 652*, 1533 Mihara, K ...... 1378 Manning, M L ...... 173 Matta, J L ...... 541* McManus, C ...... 1843 Milanez, S ...... 1624* Manoukian, R ...... 172 Mattes, W B ...... 1073*, 1905 McMartin, K ...... 464 Milatovic, D ...... 496, 498*, 1756 Mansour, M ...... 2187 Matteucci, P ...... 1454 McMillan, D A ...... 1260 Milatovic, S ...... 496, 498 Mantell, L ...... 1186* Matthews, E J ...... 905, 1133* McMullin, T S ...... 597*, 2370 Milchak, L M ...... 879* Manthei, J ...... 80 Matthews, J ...... 360, 361* McNally, A J ...... 442* Milcova, A ...... 1257 Manuel, J ...... 2060 Matthews, J L ...... 2368, 2376* McNamee, P M ...... 2275 Milicic, I ...... 1546 Mao, C ...... 1999 Matthews, M ...... 1923 McNaughton-Smith, G A ...... 618 Millburn, G ...... 1231 Marcek, J M ...... 613 Mattia, A ...... 766* McNeely, S C ...... 417, 418* Miller, A ...... 707* Marchan, R ...... 1161* Mattie, D R ...... 1279*, 2367 McNett, D ...... 589 Miller, A L ...... 1914 Marchant, C A ...... 1903, 2143 Mattingly, C ...... 998* McPhail, B ...... 680* Miller, B J ...... 835 Marchant, G ...... 1865 Mattingly, R R ...... 1176 McPherson, S M ...... 610* Miller, D ...... 73, 80, 2284 Marchant, G E ...... 386*, 720*, 1868* Mattsson, J L ...... 718, 722*, 1248 Meacham, C A ...... 1481* Miller, D B ...... 68, 70, 72, 1525*, 2417 Marcoux, M ...... 2391 Matulka, R A ...... 763, 768* Meacher, D ...... 2175 Miller, D S ...... 1754 Marcus, J ...... 1426 Matuszkiewicz, A ...... 34 Meade, B J ...... 254, 379 Miller, G W ...... 1106, 1112, 2441 Marczynski, B ...... 1252* Matz, C J ...... 147* Means, J C ...... 2056 Miller, H L ...... 417 Marinik, B J ...... 1929 Mauderly, J ...... 2212 Medina-Diaz, I M ...... 1331* Miller, J ...... 288, 1965 Marinovich, M ...... 282 Mauderly, J L ...... 241, 1201 Medverec, Z ...... 554 Miller, J A ...... 2429* Mario Cesar, S ...... 1401 Maurer, G ...... 788 Meecham, K G ...... 657*, 658, 660 Miller, J D ...... 2387 Marit, G B ...... 2322 Mauzy, C ...... 1664 Meek, E C ...... 695, 1476* Miller, J H ...... 183 Markgraf, C ...... 736 Maxwell, G ...... 376 Meeker, L ...... 1240, 2328 Miller, K A ...... 931* Markham, D A ...... 1247 May, J R ...... 656*, 2169 Meerts, I ...... 1971 Miller, K L ...... 1264, 1265, Marko, D ...... 1986* May, R D ...... 1621 Meeuwen, J v ...... 1171* ...... 1266, 1267* Marlowe, J ...... 1877 Mayeno, A N ...... 2126* Megyesi, J ...... 164 Miller, M E ...... 1782 Marlowe, J L ...... 219* Mayer, A M ...... 1396* Mehendale, H ...... 1506* Miller, M G ...... 2107, 2111, 2369 Marnett, L ...... 751* Mayer, J ...... 905 Mehendale, H M ...... 299*, 300, Miller, M L ...... 87, 931, 1810 Maroni, M ...... 281 Mayer, L P ...... 393 ...... 452, 467, 688, Miller, P ...... 293, 2091 Maronpot, R R ...... 364, 1224, Mayfield, D B ...... 859* ...... 1008, 2145, 2157, 2304 Miller, R ...... 198 ...... 1426, 2174 Mazor, K A ...... 2432 Mehendale, H M ...... 2137 Miller, R A ...... 2331 Marque, T D ...... 555 Mazzone, M ...... 292 Mehendale, H ...... 2146 Miller, R T ...... 696 Marquez-Rosado, L ...... 1644 McAtee, M ...... 51 Mehta, H ...... 1108 Miller, S ...... 867 Marr, M C ...... 1242 McBride, S ...... 40 Meibian, Z ...... 1259 Miller, T ...... 125, 1546 Marr, R ...... 566* McBride, S J ...... 2036 Meistrich, M L ...... 1547 Miller, T J ...... 295, 1665* Marroquin, L D .....1808, 1908*, 1909* McCabe, M J ...... 279, 417, 420, 1176 Mekebri, A ...... 2313 Miller, W H ...... 419 Marsden, A M ...... 1386 McCain, W C ...... 2070 Mekenyan, ...... 2295 Milleron, R S ...... 344 Marsh, E ...... 1922* McCallum, G P ...... 1434* Mekhtiev, A ...... 1250 Millett, S ...... 529 Marsh, G ...... 1174 McCarty, J ...... 943* Meldrum, B ...... 1468 Mills, D ...... 915 Marshall, B ...... 1997 McCash, C L ...... 127 Mellinger, K N ...... 1264*, 1265, Mills, L J ...... 1566* Marshall, G D ...... 326* McCaskey, D ...... 1033, 1034 ...... 1266, 1267 Millsap, D S ...... 920 Marshall, P ...... 1743 McCaskey, D A ...... 1031*, 1032 Melnick, R L ...... 2368 Min, E ...... 508 Marshall, R S ...... 46, 1475, 1478 McCaskill, M L ...... 1654* Melstrom, P C ...... 47* Min, K N ...... 1959* Marshall, V ...... 2345 McClain, C J ...... 1733 Melvin, A E ...... 2370 Mina, O ...... 1048 Marta, M ...... 1489 McClellan, R O ...... 730 Melvin, C ...... 2142 Minard, K R ...... 35 Martin, B ...... 1922 McClure, P ...... 380, 1636 Members of the NCT ToxPath Team, N Ming, J M ...... 540 Martin, D ...... 2045 McClure, P R ...... 382* ...... 313 Mink, P J ...... 2180, 2184* Martin, F ...... 615 McConnachie, L ...... 488* Menard, S ...... 1176 Minnema, D ...... 2095 Martin, L ...... 1548* McConnachie, L A ...... 234, 507 Mendez, E ...... 887*, 1425, 1428 Minnick, T ...... 1664 Martin, R ...... 638 McConnell, E E ...... 2331 Mendez, L B ...... 246 Minnick, T A ...... 841 Martin, R S ...... 237 McConnell, W R ...... 619* Mendez, W ...... 2312 Minoia, C ...... 282 Martin-Jimenez, T ...... 601 McCormack, A L .... 1105*, 1107, 1112 Mendoza-Garrido, M E ...... 2045 Minomo, H ...... 1670 Martinez, E J ...... 1793* McCormick, D L ...... 1674, 1676, Mendrick, D L ...... 82 Minsavage, G D ...... 1355* Martinez, M ...... 578, 1821 ...... 1982, 1983 Mendy, S A ...... 81 Minton, H E ...... 529* Martinez, M A ...... 578, 1489*, 1821 McCourt, M ...... 633 Menendez, D ...... 703 Mioduszewski, R ...... 69, 73, 74, Martinez-Aguilar, G ...... 2057 McCready, D I ...... 387 Meng, C K ...... 1165 ...... 75, 80, 1033 Martinez-Larranaga, M R ...... 578, McCumbee, W ...... 454 Meng, J ...... 2161 Mioduszewski, R J ...... 68, 70, ...... 1489, 1821* McDaniel, K ...... 46 Meng, Q ...... 1090* ...... 71, 72, 77
up-to-date information at www.toxicology.org 269 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Miracle, A L ...... 1565 Morgan, D L ...... 1029*, 1053 Murray, J M ...... 175* Ndifor, A ...... 1683* Mirajkar, N ...... 1473 Morgan, J ...... 899 Murray, T F ...... 1429, 2438* Ndountse-Tchapda, L ...... 614 Miranda-Gonzalez, E ...... 1354 Morgan, K T ...... 1089 Murrell, R N ...... 552* Nduaka, C I ...... 1944* Mirchandani, K ...... 2014* Morgan, R ...... 172* Musa, A M ...... 1768 Neal, B ...... 1235* Mireles, R ...... 2138 Mori, C ...... 925, 1614, 1952, Musa-Veloso, K ...... 2345 Neal, M ...... 34 Mirfazaelian, A ...... 1806, 2365* ...... 1987, 2100, 2110 Musafia-Jeknic, T ...... 55, 974* Neale, J R ...... 794*, 800, 1370 Mirshokraei, P ...... 1212 Mori, I ...... 1620 Muscarella, D ...... 1728* Nealley, E W ...... 1914 Mirsky, M ...... 679 Mori, K ...... 2132* Muscarella, D E ...... 1727 Nebert, D W ...... 87, 501, 931, Mishin, V ...... 831 Mori, T ...... 61 Muse, W ...... 80 ...... 1809, 1810, 1877, Mishin, V M ...... 1188 Morin, D ...... 490 Muse, W T ...... 70, 72 ...... 2024, 2029, 2030
AUTHOR INDEX AUTHOR Misra, H ...... 1214 Morin, E ...... 2389* Musgrove, D ...... 1750 Needham, L L ...... 2113 Misra, M ...... 2338* Morin, J ...... 523, 1187* Musgrove, D L ...... 268 Nees, D ...... 366 Misra, V ...... 1348 Morishita, K ...... 1704 Muskhelishvili, L ...... 459, 1943, 2142 Neff-LaFord, H ...... 1898 Mitchell, L ...... 264 Morishita, M ...... 2213 Mussali, P ...... 2061, 2076* Negishi, M ...... 1224, 1326 Mitcheltree, L ...... 1924 Morita, O ...... 936, 1236 Mussali-Galante, P ...... 2075 Negley, T ...... 1636, 1926 Mitchum, G ...... 1581 Morita, T ...... 1048 Muthiah, K ...... 1646, 1811, 1818 Negley, T L ...... 858 Mitkus, R J ...... 2082 Morris, D ...... 2142 Mutlib, A ...... 2138 Neilson, J W ...... 2078 Mitra, M S ...... 1008, 2157* Morris, D L ...... 1737 Mwanza, J K ...... 1479* Neimanich, R J ...... 824 Mitra, M ...... 2146 Morris, J ...... 711, 712* Myers, C B ...... 1242 Nel, A E ...... 1501* Mitroka, J ...... 982 Morris, J B ...... 1030 Myers, E A ...... 139* Nelms, L F ...... 294 Miyagawa, M ...... 1451 Morrison, E V ...... 2015 Myers, L ...... 2386 Nelo, K ...... 1680 Miyagishima, T ...... 186, 989, Morrison, R G ...... 454 Myers, L P ...... 379* Nelson, A ...... 2177 ...... 1077, 1078, Morrissey, R ...... 1677 Myers, M ...... 1685* Nelson, D M ...... 1334, 1710 ...... 1079, 1080, 1709 Morrissey, R L ...... 1982, 1983 Myers, P ...... 325, 2174 Nelson, G ...... 1206 Miyajima, N ...... 1094 Morrissy, S ...... 346 Myers, S R ...... 2359* Nelson, R B ...... 613 Miyajima-Tabata, A ...... 702* Morrow, D M ...... 1186 Myhre, K I ...... 878 Nelson, S ...... 2225* Miyamoto, Y ...... 1749 Morse, J ...... 1211 Nelson, T M ...... 615 Miyaso, H ...... 1614 Morseth, S ...... 942 Nemec, A A ...... 2047* Miyata, M ...... 2434 Morsman, J M ...... 2394* N Nemec, M ...... 49, 2437 Miyata, N ...... 2140 Moser, G ...... 1666 Nabae, K ...... 1421 Nemec, M D ...... 936, 1232*, Miyazawa, M ...... 2281, 2282* Moser, V ...... 2284, 2285 Naciff, J ...... 402 ...... 1236, 1244 Mizon, K ...... 2065 Moser, V C ...... 46, 884, 891, 1799* Naciff, J M ...... 1260, 1551* Nemery, B ...... 1840* Mizukawa, Y ...... 1709* Moses, M A ...... 469 Nadadur, S S ...... 5*, 705* Nemeti, B ...... 439 Mizuno, M ...... 2280 Moss, O R ...... 184, 1697* Nadkarni, P P ...... 806, 1038* Nesnow, S ...... 1206*, 1229 Mo, J ...... 407* Mottaleb, M ...... 1583 Nafstad, P ...... 878 Nestmann, E R ...... 1638* Mo, X ...... 191*, 1767 Mou, K ...... 1966 Nagao, T ...... 186, 989, 1077, Nett, T M ...... 7 Mobio, T A ...... 1387 Moudgal, C ...... 918 ...... 1078, 1079, 1080, 1709 Neuberg, M ...... 1859 Moerkens, M ...... 48 Moudgil, B M ...... 1045, 1561, 1562 Nagarkatti, M ...... 1162, 1895 Neumiller, J J ...... 258* Moffat, I D ...... 84 Moukha, S ...... 1387, 1388 Nagarkatti, P ...... 1895 Newbold, R ...... 1860, 2232, 2235* Moffett, D ...... 699 Moulton, H M ...... 599 Nagarkatti, P S ...... 1162 Newbold, R R ...... 400 Moffit, J S ...... 200*, 202, 1321 Moulton, R ...... 621 Nagashima, H ...... 1392* Newkirk, K ...... 1924 Moggs, J ...... 1231 Mouneimne, R ...... 1761 Nagata, R ...... 667, 1094, 1309, Newland, M C ...... 1770* Moggs, J G ...... 953, 1222, 1931* Moutot, H ...... 1532 ...... 1316, 1670, 1694, 2154 Newport, S W ...... 1002, 1005* Mohamadin, A M ...... 575 Moutvic, R ...... 619 Nagata, T ...... 1460 Newton, P E ...... 656, 2169 Mohar, I ...... 488 Mowat, F ...... 854 Nagayama, S .... 667, 1309, 1316, 1694 Ney, E ...... 2132 Mohl, B ...... 1761* Mowat, F S ...... 2201 Nair, J ...... 2083 Ng, J C ...... 1255*, 2086 Mohr, F C ...... 1567* Moyer, G ...... 1968 Naito, A ...... 2142* Ng, S P ...... 276, 928* Mohrman, M ...... 1500 Moyer, G O ...... 1958, 1970 Najarian, T ...... 624 Nguyen, A ...... 956, 1683 Moland, C L ...... 1717 Mudway, I ...... 1198 Nakagawa, H ...... 1392 Nguyen, J V ...... 1237 Molina, R ...... 1751 Mueller, J ...... 206 Nakahari, T ...... 104 Nguyen, N ...... 1807 Molinelli, A R ...... 1180* Mueller, L ...... 1131* Nakajima, M ...... 204 Ngyuen, A ...... 959 Mommers, C ...... 373* Mueller, T ...... 1347 Nakama, K ...... 1316, 1670* Ni, C T ...... 298* Moncek, F ...... 89 Muijser, H ...... 1047 Nakamura, I ...... 492 Ni, H ...... 345 Mondal, M S ...... 1668* Muir, B ...... 1245* Nakamura, J ...... 438 Ni, H ...... 1089* Moneypenny, C ...... 966 Mukhi, S ...... 176, 1580* Nakamura, M ...... 865, 1421 Niaz, M S ...... 2096 Monforte, J ...... 553 Mulhern, D ...... 2140* Nakamura, Y ...... 61*, 67 Nichkova-Dosev, M ...... 1518 Monks, T J ...... 174, 483, 574, Mullen, M W ...... 1265 Nakano, K ...... 1530 Nichols, A C ...... 1586* ...... 1381, 2122 Mullin, L S ...... 49, 50 Nakashima, H ...... 877 Nichols, T ...... 1636*, 1926 Monteiro-Riviere, N ...... 27*, 29 Mumford, J ...... 407, 408* Nakashita, Y ...... 1620 Nichols, T A ...... 1947* Monteiro-Riviere, N A ...... 28*, 812, Mumtaz, M ...... 915, 1603, Nakatsuka, H ...... 107 Nichols, W K ...... 1881 ...... 823, 824, 825, ...... 1628*, 2304 Nakayama, Y ...... 67* Nicholson, J D ...... 1914 ...... 826, 827*, 828, 843 Mun, G ...... 559, 1595, 1968, 1970 Nam, K ...... 555 Nicholson, J K ...... 161 Monteith, D K ...... 12, 13* Mundy, W ...... 2116 Nam, P ...... 1558 Nickerson, C ...... 175 Montine, T J ...... 498 Mundy, W R ...... 1430*, 2414 Nambiar, M P ...... 79, 1035 Nicol, C J ...... 1321 Moon, H ...... 1049, 1938 Munro, I C ...... 2346* Namorado, M C ...... 2045 Nicolescu, A C ...... 643, 644* Moore, C ...... 1302 Munsie, L M ...... 289 Nancy, C ...... 251 Nicoll, J ...... 1167 Moore, D ...... 1931 Munson, A E ...... 254 Nanez, A ...... 156* Nicolli, A ...... 1465* Moore, D D ...... 1001, 1327 Munson, J W ...... 410 Nanjan, M ...... 1985 Niedzwiecki, A ...... 1398 Moore, D J ...... 953 Muppana, L ...... 1344 Naoki, K ...... 798 Niehaus, M ...... 2105, 2106* Moore, D W ...... 1284 Murakami, T ...... 193, 676, 693, Napolitano, G ...... 182 Niehof, M ...... 1346 Moore, E L ...... 1937* ...... 798, 868, 2269* Naragoni, s ...... 404* Niehoff, M ...... 2364* Moore, K R ...... 615 Murakami, Y ...... 83 Narahashi, T ...... 1490 Niemuth, N ...... 1923 Moore, M M ...... 536, 2208 Muralidhara, S ...... 680, 1431, 1803 Narai, R ...... 868, 2269 Nieuwenhuizen, P ...... 2253 Moore, M R ...... 1255 Murata, K ...... 107 Narayan, S ...... 949 Nihart, V ...... 785 Moore, N ...... 1437* Muratore, N ...... 2151 Nardi, C ...... 1722 Niino, N ...... 206 Moore, P K ...... 2136 Murli, H ...... 555 Nareddy, V B ...... 956* Niittynen, M ...... 84* Moore, R ...... 1326 Murnane, M ...... 2423 Nash, J F ...... 2373* Nijmeijer, S ...... 1543 Moore, R J ...... 183 Muro-Cacho, C ...... 2406 Naspinski, C ...... 525, 1250 Nikolskaya, T ...... 668 Moore, S A ...... 657, 1699* Muro-Cacho, C A ...... 2407 Nasreen, N ...... 1045 Nilles, T ...... 1348 Moore, T B ...... 2290 Murono, E P ...... 390, 2102* Nass, R ...... 1763, 1785, 1786 Nines, R G ...... 958 Moore, T M ...... 157 Murphy, G ...... 1054* Nass, R M ...... 1843* Ninomiya, S ...... 2140 Moorthy, B ...... 1646, 1811*, Murphy, J ...... 248, 285*, 286 Nasser, F ...... 1462* Nishida, A ...... 1423 ...... 1812, 1818 Murphy, K A ...... 832* Nasser, F A ...... 1463 Nishijima, Y ...... 1529 Moos, P J ...... 1164 Murphy, L ...... 1245 Nataraj, S M ...... 1978* Nishikawa, A ...... 972, 978, 2134* Moraga, D A ...... 1561 Murphy, R C ...... 748* Natsoulis, G ...... 987, 1889* Nishimura, H ...... 1539 Moran, T E ...... 79, 1035 Murr, A ...... 1946, 1948 Nau, M ...... 80 Nishimura, N ...... 1539* Moreland, R A ...... 406 Murr, A S ...... 389* Naufal, Z S ...... 525, 1251* Nishimura, T ...... 1213* Moreland, S ...... 953 Murray, A R ...... 846*, 1556 Naufel, Z S ...... 1250 Nishiwaki, Y ...... 877 Moreno-Contreras, M ...... 103* Murray, B P ...... 1819 Naylor, J ...... 1676* Nitka, S ...... 1597, 2347 Moretto, A ...... 1465 Murray, E ...... 699 Naylor, T L ...... 1056, 1241 Nitschke, K D ...... 1052
270 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Noailles, P H ...... 2418 Ohshima, Y ...... 2140 Oyama, T ...... 193, 676*, 693, Parzych, B ...... 1684 Noh, J ...... 2054* Ohtsuki, K ...... 61 ...... 798, 868, 2269 Pascal, L E ...... 2050 Nohara, K ...... 1749* Okamoto, K ...... 159*, 2280 Ozawa, S ...... 702 Paskalev, Z D ...... 1043* Nohmi, T ...... 972 Okamoto, M ...... 2043 Ozden, A ...... 118 Pasman, W ...... 930 Nohynek, G J ...... 1151, 1154* Okamoto, Y ...... 636 Ozel, S ...... 118 Pasquinelli, M A ...... 1887* Noisel, N ...... 870* Okano, K ...... 972 Ozias, M ...... 1988 Pastoor, T ...... 1231 Noker, P ...... 603 Okatani, H ...... 1309, 1316* Patapoff, T ...... 844 Nolan, J P ...... 1698 Okazaki, O ...... 1621 Patel, A ...... 1290, 1310 Nomura, F ...... 1614 Okerberg, C V ...... 623 P Patel, D ...... 179*, 648 Nomura, Y ...... 1482 Okey, A B ...... 84 Pabello, N ...... 327 Patel, H J ...... 607 Nong, A ...... 893, 2382* Okino, M ...... 2383* Pack, D ...... 1046 Patel, K M ...... 2419 Nony, P ...... 1254 Okino, M S ...... 1219, 1276 Padilla, S ...... 46*, 138, Patel, M ...... 741, 745*, 1101 Norbury, K C ...... 1691* Oko, L M ...... 1828 ...... 148, 1431, 1475, Patel, M L ...... 1903, 2143 Nordberg, G F ...... 2025* Okoh, V ...... 949 ...... 1478, 2284, 2285 Patel, N ...... 497*, 1979 Nordberg, M M ...... 2052* Ola, T ...... 285 Padilla-Banks, E ...... 400, 2235 Patel, N N ...... 2408*, 2409 Norderhaug, I N ...... 878 Olaharski, A J ...... 1997* Padmavathi, L ...... 220 Patel, R D ...... 208* Nordone, P ...... 1534, 1662* Oldham, M ...... 231, 802 Padovani, A S ...... 419 Patel, S ...... 1979 Norhadian, S ...... 2085 Olin, S ...... 2333 Padowski, J M ...... 1672* Patierno, S R ...... 2049 North, C ...... 1708 Oliveira, P J ...... 1713, 2342 Paehler, A ...... 506 Patil, N ...... 1907* Norton, K ...... 650*, 661, 1308 Oliver, G J ...... 1281, 1282, 1904 Paepke, O ...... 90*, 1544 Patino, R ...... 1580 Norwood, A B ...... 1486, 1487* Olivero, O ...... 540* Pagan, D ...... 2000 Patlewicz, G ...... 377 Norwood, D L ...... 732* Olivero, O A ...... 971 Pagan, I ...... 1146* Patlolla, A K ...... 517* Norwood, J ...... 937 Olivero-Verbel, J ...... 103 Page, D ...... 2083 Patten, D ...... 1303 Note, R R ...... 1903, 2143* Olivier, K J ...... 634* Patterson, R ...... 1750* Page, G ...... 664 AUTHOR INDEX Novak, M J ...... 1911 Olivier, W ...... 251* Page, L ...... 606 Patterson, S ...... 2150 Novak, R F ...... 671 Olsen, C E ...... 437 Page, T ...... 1353* Patterson, T ...... 126 Novotny, L ...... 515 Olsen, G ...... 603*, 2385 Page, T J ...... 2093 Patterson, T A ...... 1461 Nuber, D ...... 943, 1689* Olson, E ...... 1944 Pai, S J ...... 1972* Patterson, T J ...... 976* Nwagbara, O F ...... 2114* Olson, J R ...... 95, 781, 1207 Paigen, K ...... 1616 Patton, G ...... 991* Nye, S ...... 1296, 1298 Olson, M J ...... 1283, 1299*, 2276 Pakkenberg, B ...... 48 Pauff, M K ...... 2363 Nye, S H ...... 1617* Olson, P H ...... 1921 Palacio, K ...... 627, 1314 Paul, D S ...... 412*, 413 Nyland, J ...... 284 Omae, K ...... 107, 877, 2043 Palacio, K A ...... 631* Paulauskis, J ...... 298 Nyland, J F ...... 1175 Omaye, S ...... 1916 Palazuelos, M ...... 1561* Paule, M ...... 126 Nylander-French, L A ...... 808, 839 Omenaas, E ...... 878 Palkar, P S ...... 299, 300*, 2304 Paule, M G ...... 1459, 1461 Nyska, A ...... 1194, 1537, Omura, K ...... 1080* Pallardy, M ...... 1734, 1894 Paules, R ...... 311, 462 ...... 1538, 1666, 1831, 2174 Onda, H ...... 984 Pallardy, m J ...... 1143* Paules, R S ...... 313*, 1000, 1081, 1093 Ondov, J ...... 860 Pallez, C ...... 192 Paulsen, D ...... 804, 1040 Onen, A ...... 118 Palmeira, C M ...... 484*, 1713 Paulsen, D B ...... 1054 O Ong, M M ...... 2136* Palmer, S M ...... 1029 Paulsen, M H ...... 229 O Callaghan, J P ...... 2419 Ono, A ...... 186, 989*, Palmer, V ...... 132, 252 Pauluhn, J ...... 1025*, 1523* O’Brien, E ...... 472, 473, 474, ...... 1077, 1078, 1079, Palmiter, R ...... 1109 Paulus, B ...... 2069 ...... 475, 476, 477* ...... 1080, 1709, 2128 Palumbo, A ...... 1936* Paustenbach, D ...... 848, 1254, 1870* O’Brien, P ...... 689 Onodera, H ...... 1530 Pan, M ...... 1417 Paustenbach, D J ...... 561, 570, O’Brien, T ...... 54 Opanashuk, L ...... 2436 Pandey, S ...... 1160* ...... 851, 852, 857*, 1253, O’Brien, T J ...... 2049* Opanashuk, L A ...... 1449 Pandini, A ...... 354, 356 ...... 1264, 1266, 1536, 1865 O’Brien, T M ...... 2342* Operana, T N ...... 1807* Panke, H ...... 1634 Pawliuk, R ...... 633* O’Callaghan, J ...... 48, 1507* Orberg, J ...... 1574 Panko, J M ...... 857 Pawlowski, V ...... 1859 O’Callaghan, J P ...... 2417 Ordonez L, J ...... 2061 Panuwet, P ...... 1237 Peake, J ...... 121 O’Connor, J ...... 1296, 1298* Orehek, M ...... 80 Papagiannis, C N ...... 626 Peal, A ...... 1681*, 1682 O’Connor, J C ...... 2325 Orelien, J ...... 1263 Papanayotou, I ...... 460 Pearce, J T ...... 161 O’Halloran, K ...... 1736 Orisakwe, O E ...... 1995* Papasavva, N ...... 2293 Pearse, G ...... 1671 O’Hara, K A ...... 2047 Orlando, E F ...... 1565 Papineni, S ...... 1157, 1324* Pearson, C ...... 182*, 987 O’Hara, M ...... 141 Orlicky, D ...... 468 Papkovsky, D ...... 1908, 1909 Pearson, E ...... 1461, 1648 O’Kane, J ...... 700 Orphanides, G ...... 953, 1222, 1931 Papoian, R ...... 788 Pechan, T ...... 63 O’Keefe, M ...... 2000 Orr, M S ...... 1073 Papoian, T ...... 1856* Peck, E C ...... 234* O’Keefe, R J ...... 365, 1376 Orrenius, S ...... 741, 743* Pappa, A ...... 468 Peddada, S ...... 967, 1666 O’Neill, H C ...... 632* Ortel, T L ...... 1666 Paquet, L ...... 805 Peden-Adams, M ...... 256*, 288, O’Neill, T P ...... 2165* Ortiz, J L ...... 307 Parameswarann, V ...... 1160 ...... 571, 1581 Oberdorster, E ...... 1584* Ortiz, M V ...... 307 Pardo, N E ...... 2439 Peeper, H J ...... 1297* Oberdorster, G ...... 22, 25*, Ortiz de Montellano, P ...... 2222* Parent, R ...... 717*, 2318* Peffer, R C ...... 1231* ...... 1849*, 1852, 2333 Ortiz-Serrano, M ...... 2386 Parenteau, M ...... 101 Pegg, D G ...... 328*, 334* Obert, L A ...... 1746 Orton, C R ...... 1016* Parfett, C ...... 181 Peggins, J O ...... 2363 OBrien, E ...... 471 Orton, T C ...... 1386 Parham, F M ...... 1890 Pei, L ...... 1251 Odin, M ...... 918, 1636, 2300 Orzech, D ...... 1422 Paris, M ...... 1969, 1970* Peijnenburg, A A ...... 1170 Odin, M A ...... 1274 Orzech, D P ...... 2132 Paris, M W ...... 1968 Peksa, R L ...... 1396 Odum, J ...... 953 Osborne, C L ...... 146* Park, C ...... 1413 Pelgrim, M ...... 48 Oehme, F W ...... 2202 Osburn, W O ...... 1348* Park, E ...... 1518, 2064 Pelkonen, J ...... 2012 Ofordile, O N ...... 283 Oscar, T ...... 1401 Park, E S ...... 1752 Pellerin, B ...... 2388, 2389 Ogata, S ...... 206* Oshima, J ...... 549 Park, H ...... 1076 Pelletier, D ...... 1630* Ogawa, K ...... 962* Osier, M ...... 2198 Park, J ...... 415, 2064, 2396 Pellicore, L ...... 1984 Ogawa, M ...... 193*, 676, 693, Osipov, A N ...... 1158, 1557, Park, J D ...... 1752* Pelsue, S C ...... 1724* ...... 798, 868, 2269 ...... 2003, 2004 Park, J S ...... 34 Peltz, G ...... 548 Ogawa, T ...... 1427*, 1460 Oskarsson, A ...... 1173* Park, K ...... 269, 2334 Pena-Philippides, J ...... 76 Ogden, K I ...... 2349 Osterburg, I ...... 132 Park, R ...... 188 Pendlington, R ...... 690 Ogden, L ...... 2187* Ostrosky-Wegman, P ...... 1354 Park, S ...... 1049, 1339, Peng, L ...... 218, 1015 Ogilvie, K ...... 627 Othumpangat, S ...... 2044* ...... 1344, 1359, 2053 Peng, S ...... 2159*, 2434 Oguma, E ...... 2031 Otto, M ...... 48, 930 Park, Y ...... 1719 Peng, Z ...... 1015* Ogura, M ...... 2128 Ouellet, M ...... 2177* Parker, G A ...... 2070* Penn, A ...... 804*, 1040, 1054 Oh, K ...... 677, 1216, Ouyang, M ...... 54 Parker, J ...... 513, 1000 Penn, C ...... 869 ...... 1371, 1393, 1400, Ovando, B J ...... 95, 781* Parker, J S ...... 1890, 2132 Pennanen, A S ...... 239 ...... 1403, 1407, 1813 Overman, G J ...... 1551 Parker, S ...... 252 Pennell, K D ...... 1112, 2441 Oh, K N ...... 86, 1218* Overmann, G ...... 402 Parkinson, H D ...... 168 Pennings, J ...... 1896 Oh, S ...... 671 Owen, M ...... 1968, 1970 Parnell, S E ...... 139 Penninks, A H ...... 2253 Ohlsson, C ...... 88 Owen, R ...... 53 Parng, C ...... 39, 1535 Penton, H ...... 661*, 1308, 1531 Ohmichi, K ...... 1614* Owen, R D ...... 432 Parran, D ...... 1468 Penttinen, P ...... 2012* Ohmichi, M ...... 1614 Owen, S ...... 2245* Parron, V ...... 970 Pepperl, S ...... 1245 Ohmukai, H ...... 1460 Owen, S F ...... 2243 Parry, J D ...... 512* Peraza, M A ...... 207* Ohnishi, T ...... 761, 1657* Owens, D M ...... 59 Parry, T ...... 293 Perdew, G H ...... 208 Ohno, Y ...... 702, 2280 Owens, R ...... 1924 Parsley, M A ...... 495 Pereira, C ...... 1964* Ohsako, S ...... 83 Oxendine, S ...... 138*, 148 Parviz, M ...... 1792* Pereira, C B ...... 1227 up-to-date information at www.toxicology.org 271 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Pereira, F E ...... 423* Piterski, C ...... 1597 Prior, H ...... 652 Ramiro-Ibanez, F ...... 1669 Perentes, E ...... 788 Pitta, C ...... 2293 Pritsos, C A ...... 1576 Ramos, J ...... 541 Peri, R ...... 662* Pittman, J ...... 1476, 2374* Proctor, D ...... 1612 Ramos, K S ...... 156 Perkins, E J ...... 786, 1564, 1920 Pittmen, J ...... 568 Proctor, J ...... 245 Ramot, Y ...... 1666* Perkins, G A ...... 1791* Pitts, D K ...... 1795 Prodon, D ...... 94 Ranatunga, D C ...... 1725, 1730 Perleberg, U R ...... 2367 Piyachaturawat, P ...... 2131 Proll, S ...... 1446 Randall, J C ...... 550 Pero, R ...... 1944 Plant, K A ...... 1173 Protain, A C ...... 1828 Rangan, V ...... 1189, 1190* Perraut, C ...... 609 Plante, I ...... 960* Protain, H J ...... 1828 Ranjan, R ...... 1362* Perrone, C E ...... 303*, 616 Plante, M ...... 870 Proteau, R R ...... 1686 Rankin, G O ...... 466* Perry, M W ...... 1266* Platoff, G E ...... 1918 Protopapa, F ...... 42 Rannug, A ...... 89
AUTHOR INDEX AUTHOR Perry, N B ...... 60 Platz, S ...... 1075 Protzel, A ...... 2295* Rao, K ...... 608 Persad, A S ...... 763 Pletcher, J ...... 1683 Prough, D S ...... 495 Rappaport, S M ...... 2358 Pershouse, M ...... 1092 Plewa, M J ...... 2299 Prough, R ...... 510 Rashid, A ...... 967 Person, M D ...... 483 Plopper, C ...... 9, 35 Proutski, V ...... 997 Rasoulpour, R ...... 2098* Perumal, T E ...... 1189, 1190 Plopper, C G ...... 678, 724*, 1026, Prozialeck, W C ...... 449, 1663*, 2022 Rasoulpour, T ...... 2099* Pesch, B ...... 1252 ...... 1027, 1066, 1136* Prucha, M S ...... 1352* Ratajczak, H V ...... 1738* Pessah, I ...... 1450 Plotzke, K ...... 589, 1240, 2328 Prues, S L ...... 1241 Ratcliffe, K ...... 2259 Pessah, I N ...... 1452 Plotzke, K P ...... 1239, 1827, Pruett, B S ...... 262* Ratcliffe, R ...... 1924 Pestka, J ...... 261, 1012, 1990 ...... 1929, 1940* Pruett, S B ...... 262, 263, 325*, Rath, M ...... 1398 Pestka, J J ...... 999, 1028, 1989 Plummer, S ...... 56, 926* ...... 1744, 1893, 1899* Rathod, J ...... 1979 Peters, A K ...... 1543* Plunkett, L M ...... 383* Pruimboom-Brees, I ...... 630, Raulf-Heimsoth, M ...... 1252 Peters, J M ...... 207, 965 Pluta, L ...... 1353 ...... 1006, 1684 Ravel, G ...... 270*, 271 Petersen, D ...... 494 Pluta, L J ...... 2093 Psurny, E A ...... 2363 Ray, A ...... 1473 Petersen, D D ...... 2179* Poet, T S ...... 32*, 33, 583, 2308* Pu, X ...... 955* Ray, E J ...... 1569* Petersen, D R ...... 2398, 2404 Pogge, A R ...... 2419 Puatanachokchai, R ...... 1228 Ray, S D ...... 497, 1979* Petersen, L A ...... 409 Pohjanvirta, R ...... 84 Puga, A ...... 215, 218, 219, Raymond, G M ...... 34 Petersen, M ...... 2097 Pohl, L R ...... 1010 ...... 414, 1377, 1877 Rayner, J L ...... 399, 406, Peterson, B ...... 499* Poirier, L A ...... 2129 Pumford, N ...... 1901 ...... 1237*, 2077 Peterson, L ...... 2158 Poirier, M ...... 1748 Purcell, W M ...... 1956 Razani-Boroujerdi, S ...... 76 Peterson, L D ...... 2188 Poirier, M C ...... 540, 971 Purisai, M G ...... 1105, 1107* Reams, R R ...... 1762* Peterson, R ...... 198 Politano, V T ...... 933* Purmal, A ...... 2091 Reaney, S H ...... 1098*, 1105 Peterson, R E ...... 128, 921, 922, Pollack, G M ...... 1672 Putnam, E A ...... 1092* Reaves, E ...... 887, 2284 ...... 923, 924, 2160, 2172 Pollard, D L ...... 841 Putt, D A ...... 460 Reaves, M ...... 2285 Peterson, S L ...... 355 Pollard, J ...... 1859 Puzas, J ...... 365*, 1376 Recendez, J J ...... 240 Peterson-Roth, E ...... 524 Pollenz, R S ...... 8*, 214, 357, Pyatt, D ...... 114* Rechetnik, E ...... 1741* Petit-Turcotte, C ...... 1301* ...... 775, 776, 1116* Pyo, H ...... 273, 791, 2268 Recio, L ...... 546*, 1291* Petrali, J P ...... 821 Polman, J ...... 997* Python, F ...... 43* Reddy, C S ...... 1404 Petreas, M ...... 109 Polverino, T ...... 1675 Reddy, G ...... 600*, 2366 Petropoulou, C J ...... 1610 Pomeroy-Black, M J ...... 1470* Reddy, M ...... 2123, 2377 Petry, T ...... 1626* Poole, C ...... 198 Q Reddy, M T ...... 599 Pettan-Brewer, C ...... 1446 Poortman, J H ...... 1170 Qian, M ...... 503 Reddy, R ...... 1978 Pettersen, B A ...... 613* Pope, C ...... 1473, 1474 Qian, Y ...... 339 Reddy, V ...... 2 Pettersen, J C ...... 630* Popp, M ...... 1561 Qiao, D ...... 1440 Reed, J M ...... 2029* Peuler, J D ...... 449, 2022 Porter, K ...... 1547* Qin, H ...... 1117 Reed, K L ...... 243, 1050, 1051 Peyret, T ...... 1273 Portier, C J ...... 1890, 2371, 2376 Qin, L ...... 162 Reed, M ...... 1770 Pezzoli, P ...... 553 Portier, C R ...... 1537 Qin, Z ...... 1098 Reed, M D ...... 232*, 634 Pfeifer, K F ...... 2290 Portier, K M ...... 1631 Qu, W ...... 58, 429, 1020, Reed, N ...... 2292 Pfeiffer, E ...... 675* Portilla, D ...... 164 ...... 2027*, 2055 Reed, N R ...... 2291* Pfeiffer, J ...... 1037 Portsmouth, C ...... 376* Quan, C ...... 1196* Reed, W ...... 639, 640 Pfuhler, S ...... 518 Possolo, A ...... 1540, 1541 Quattrochi, L ...... 1341 Reeder, M K ...... 558, 2274*, 2278 Phelps, L ...... 253 Post, G B ...... 1608* Que, A ...... 1668 Rees, J N ...... 1095* Phenrat, T ...... 513 Postlethwait, E ...... 35 Qui, H Z ...... 465* Rees, P ...... 1592 Philbert, M A ...... 2428, 2429 Postlethwait, E M ...... 1066 Quijano, M ...... 1590 Reeves, B ...... 2083 Philip, B K ...... 299, 300, 2137, 2304* Postoyalko, A ...... 1747* Quinn, A L ...... 1929* Reeves, B S ...... 1953* Phillips, C S ...... 1917, 1920 Potapovich, A ...... 1163 Quintana, P ...... 1262 Regal, J F ...... 1497, 1500* Phillips, D H ...... 790 Potapovich, A I ...... 1557 Quintanilla-Vega, B ...... 2057, 2108 Regal, R R ...... 1500 Phillips, J M ...... 1224* Potapovich, M ...... 1158 Quynh, H T ...... 90 Regan, C ...... 384 Phillips, P ...... 46 Potnis, P A ...... 2082* Regan, J M ...... 1929 Phillips, P M ...... 1799 Potts, E N ...... 1044* Regnier, J ...... 940* Phillips, T ...... 1577 Poulin, D ...... 1695 Reich, A ...... 584 Phillips, T D ...... 525*, 871 Pouliot, L ...... 611, 612* R Reichard, J F ...... 414* Phillips, W ...... 2369 Pounds, J G ...... 183, 2127 Raabe, H ...... 1968, 1970 Reid, F ...... 1923* Phimister, A ...... 1450 Powell, C ...... 312 Raabe, H A ...... 1958 Reid, J B ...... 1274 Phipps, D ...... 1528 Powell, C J ...... 2399 Rabieh, S ...... 416 Reilly, C A ...... 242, 1164, 1385 Phipps, R P ...... 1653 Powell, C L ...... 1225* Rabinowitz, J R ...... 1887 Reilly, K W ...... 1241 Pi, J ...... 58* Powell, D A ...... 431 Rabussay, D P ...... 817 Reilly, T P ...... 245*, 1124, 1710 Piacente, M ...... 1691 Powell, E ...... 2060 Rached, E ...... 963 Reily, M ...... 623, 1859 Piatigorsky, J ...... 366 Powell, J ...... 633 Racz, W J ...... 643, 644 Reily, M D ...... 173 Piccotti, J R ...... 1737*, 1746 Powell, J L ...... 700, 2082 Raczynski, A ...... 2422 Reimers, M J ...... 38 pickrell, j a ...... 2202* Powell-Coffman, J A ...... 1117* Radilov, A ...... 2344 Reiners Jr., J ...... 220 Pierce, J ...... 854*, 2422, 2423 Power, F W ...... 1219, 1276, Raemisch, A ...... 637 Reinhard, M ...... 622 Pierce, J S ...... 1870 ...... 2379*, 2383 Raffaele, K ...... 1425* Reinke, L ...... 2402 Pierce, W M ...... 642, 794, 800 Powers, B E ...... 1453* Raffaele, K C ...... 1428 Reisfeld, B ...... 2126 Pierre, N ...... 481 Powers, K ...... 1082 Rahmioglu, N ...... 381 Reising, A ...... 2141* Piersma, A ...... 1171 Powers, K W ...... 1561 Railer, R ...... 1924 Reiterer, G ...... 305 Pin, S ...... 2151 Powers, M J ...... 1601, 1966* Railer, R F ...... 81 Rejeski, D ...... 1584 Pina-Guzman, B ...... 2108* Poynton, H C ...... 1564* Rajab, N F ...... 1165 Reliene, R ...... 528*, 549, 977, 1643 Pinard, G ...... 1748* Prabhu, S K ...... 196 Rajagopalan, S ...... 1196, 1197 Remon, J ...... 1598 Pine, P ...... 125, 2393* Prabhu, V ...... 2418 Rajapaksa, K ...... 1550* Ren, S ...... 615, 1625 Pine, P S ...... 158 Prahl, L K ...... 364 Rajendran, N ...... 2338 Render, J ...... 620 Pinheiro, F ...... 2084* Prater, M R ...... 136, 137* Rakhmatulin, E ...... 668 Renganathan, M ...... 659 Pinkerton, K ...... 2353 Pratt, D ...... 1859 Ramachandiran, S ...... 1106* Renne, R A ...... 230, 1090, 1661 Pinkerton, K E ...... 240, 807 Prenni, J ...... 1217 Ramakers, G ...... 1457 Rennen, M ...... 896 Pinn, L C ...... 137 Prentiss, P ...... 1217 Ramanujam, V ...... 495 Renner, J A ...... 70 Pinney, V R ...... 2348* Preterre, D ...... 1187 Ramasamy, S ...... 669* Reppen, T ...... 201 Pinon-Zarate, G ...... 2061, 2075 Preuss, R ...... 1252 Ramasubramanian, B ...... 2139 Resnick, M ...... 703 Pira, E ...... 1767 Price, H C ...... 1053 Ramesh, A ...... 2096*, 2112 Retief, J ...... 1889 Pirone, J R ...... 2371* Prince, A ...... 1009 Ramirez, A ...... 785 Rettenmeier, A W ...... 416 Piskac, A L ...... 453* Prins, J ...... 1797* Ramirez, A J ...... 1583 Reuhl, K ...... 952 Pita, R ...... 578 Prinsen, M K ...... 1594 Ramirez, P ...... 521* Reuhl, K R ...... 1781*, 1783 Ramirez-Zetina, M ...... 1262 272 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Reuter, L ...... 511 Roche, A ...... 457* Rouault, T A ...... 2062 Sakaguchi, H ...... 2279*, 2280, Reutter, S A ...... 1925 Roche, B ...... 1529 Rouleau, N ...... 1739 ...... 2281, 2282 Reyes, B ...... 2045 Rockett, J C ...... 1692 Round, D ...... 1211 Sakai, S ...... 1055* Reyes, C ...... 1599 Rockwood, G ...... 69 Rouquie, D ...... 2254 Sakemi, S ...... 163 Reyes, J L ...... 2045 Rockwood, G A ...... 1918 Rouse, D ...... 2174 Sakimura, M ...... 1315, 1906 Reymann, S ...... 224*, 1088 Rodriguez, A ...... 2111* Rouse, J G ...... 826* Sakurai, T ...... 411* Reynolds, C L ...... 2152* Rodriguez, C ...... 535* Rouse, R ...... 804, 1040* Salazar, A ...... 1354* Reynolds, E ...... 1475 Rodriguez, V M ...... 1488*, 1769 Rowan, W H ...... 1698, 2173 Salcido-Neyoy, M E ...... 1644* Reynolds, M ...... 524 Rodriguez, V P ...... 592, 593 Rowlands, J ...... 1243* Saldivar, L ...... 2075 Reynolds, M F ...... 532* Rodriguez, W ...... 2152 Rowton, S ...... 2267* Saleh, N ...... 513 Reynolds, S H ...... 1059 Rodriguez-Lara, V ...... 2061, 2075 Roy, D ...... 949, 1335, 1933 Sales, G ...... 1998 Reynolds, V L ...... 628*, 629 Roede, J ...... 494* Roy, N ...... 39, 1535 Salinas, J E ...... 1814 Rezk, P E ...... 79*, 1035 Roegge, C ...... 609* Roy, S K ...... 178 Salinas, K A ...... 1568 Reznikova, T V ...... 433* Roels, H A ...... 188 Roycroft, J H ...... 2132 Salmen, R ...... 1555 Rhee, G ...... 401 Roesch, P L ...... 201 Royland, J E ...... 1433* Salmon, A G ...... 882, 901, 1605, 2185 Rhim, T ...... 2130* Rogers, C ...... 633 Rozman, K K ...... 98 Salmon, F ...... 930 Rhule, A ...... 1397* Rogers, J ...... 1922 Rubin, A L ...... 2290 Salonen, R ...... 1193 Rice, C ...... 1581 Rogers, J M ...... 937 Rubin, K ...... 2032 Salonen, R O ...... 238, 239 Rice, G E ...... 1274 Rogers, K R ...... 1517* Rubio-Andrade, M ...... 112, 280 Salt, S E ...... 427 Rice, J ...... 40 Rogers, L K ...... 123, 2351* Rubis, J ...... 53 Salvail, D ...... 650, 651, 664* Rice, R H ...... 433, 976 Rogers, R L ...... 1570 Ruby, M V ...... 409, 410 Samaniego, A ...... 1688 Rice, S ...... 1635 Roggen, E ...... 375, 2265 Ruchirawat, S ...... 1951 Sambuco, C P ...... 818, 819*, 2087 Rich, I N ...... 1319*, 1320* Roh, S ...... 1407, 1410, Ruckman, S ...... 1937 Samet, J M ...... 639, 640, 1014, 1513* Richards, J ...... 2411 ...... 1411, 1412* Ruddock, W ...... 1293* Samia, R ...... 1958 Richards, J H ...... 1062, 1063, 1194 Rohde, C A ...... 1846 Ruelland, B ...... 1748 Saminathan, H ...... 2007* AUTHOR INDEX Richards, L ...... 617 Rohde, C M ...... 173* Rufer, E S ...... 144* Sampson, M ...... 182 Richards-Smith, B ...... 984 Rohr, A ...... 2211 Ruiz, A ...... 541 Sanborn, J R ...... 2313* Richardson, A ...... 2083 Rohr, A C ...... 2210*, 2215* Ruiz, P ...... 1603*, 1628, 2211 Sanchez, E I ...... 2045 Richardson, J R ...... 1106, 1112, 2441 Rojas-Garcia, E ...... 2108 Rumpf, S K ...... 472, 473, 474, Sanchez-Pena, L C ...... 1256, Richardson, R J ...... 1462, 1463 Rojas-Lemus, M ...... 2061, 2075 ...... 475, 476, 477 ...... 1769, 1798 Richardson, V ...... 1169* Roling, J A ...... 1563* Runge-Morris, M ...... 17, 17, 18* Sanders, J M ...... 100, 1878*, 2371 Richburg, J H ...... 2019, 2020* Rolle, J ...... 1600 Runkel, M ...... 472, 473, 474, Sanders, M ...... 161 Richfield, E K ...... 1108 Rollins-Hairston, A M ...... 674 ...... 475, 476*, 477 Sanders, R A ...... 920 Richoz, L ...... 518 Rolo, A P ...... 484, 1713, 2158* Runkle, S A ...... 2428* Sanders, V M ...... 323, 324* Richter, P ...... 1291 Romach, B ...... 198 Russak, M ...... 862 Sanders, W E ...... 408 Richter, R O ...... 570* Roman, I ...... 2153 Russel, L ...... 1654 Sanderson, T ...... 982, 1543, Rick, D L ...... 685, 1248 Roman, R ...... 1296, 1298 Russell, R ...... 1892 ...... 2089, 2095* Rickert, W S ...... 1965 Roman, R J ...... 1617 Rusyn, I ...... 162, 194, Sandhu, J ...... 1160 Riess, A ...... 675 Romano, T ...... 1581 ...... 311*, 312*, 316, Sandstrom, R ...... 1420 Rigdon, G C ...... 618 Romer, E J ...... 1725*, 1730 ...... 1126*, 1225, 1616 Sandstrom, T ...... 1198 Riggins, J N ...... 509 Romics, I ...... 698 Rutherford, M ...... 1500 Sandwick, S J ...... 519 Rijal, S ...... 1480* Roney, N ...... 1629, 2198 Rutkowski, J ...... 132 Sandy, M S ...... 113*, 122, 899, 910 Riley, G ...... 455 Ronis, M J ...... 1368, 1651, Ryabov, A ...... 668 Sano, Y ...... 877 Riley, M R ...... 2349 ...... 2401, 2403 Ryan, B C ...... 405* Sansone, J ...... 789 Riley, P ...... 1590 Ronn, M ...... 1574 Ryan, C ...... 377, 1144*, 2277* Santa Cruz, V ...... 940 Riley, R ...... 1496 Roomi, M ...... 1398* Ryan, C A ...... 378, 2273, 2275 Santhanam, P ...... 1852 Riley, R T ...... 1492, 1494, 1992, 1993 Rooney, A A ...... 2196* Ryan, D ...... 753* Santiago, L Y ...... 1135 Rine, J ...... 1997 Rooney, R ...... 179, 648* Ryan, E P ...... 1653* Santos, J H ...... 744 Ripoll, V ...... 1532 Roongta, V ...... 161 Ryan, J ...... 1544 Santra, S ...... 1562 Rise, M L ...... 1119 Roop, B ...... 54, 1205, Ryan, L ...... 1426 Sarafian, T A ...... 802* Ritchie, G D ...... 2321 ...... 1206, 1229 Ryan, M J ...... 1422 Saranko, C J ...... 1631* Ritov, V ...... 2005 Rosales-Gonzalez, M ...... 280 Ryan, S ...... 175, 1922 Sarazan, R D ...... 649 Ritter, L ...... 1871 Rose, K ...... 2141 Ryan, T ...... 199 Sardo, C L ...... 1648 Riviere, J E ...... 812, 823, 824, Rose, R L ...... 1209 Ryan, T P ...... 1527, 2392 Sargent, D E ...... 49, 50 ...... 827, 828, 842, 843* Rose, S H ...... 308 Rybina, I ...... 1958 Sarkar, S ...... 1720* Roberts, A ...... 995*, 1300, 2335* Rosemond, Z ...... 2298 Ryman-Rasmussen, J ...... 827 Sarlo, K ...... 375, 2265 Roberts, D W ...... 829* Rosen, M ...... 932* Ryman-Rasmussen, J P ...... 828* Sarmiento, L A ...... 881 Roberts, E S ...... 646* Rosenfeld, C ...... 1215* Ryrfeldt, A ...... 1633 Sarra, J D ...... 607 Roberts, J C ...... 1650 Rosengarten, A ...... 1910 Ryu, D ...... 2268, 2396* Sasaki, Y ...... 1423 Roberts, J D ...... 1611* Rosengren, R J ...... 60, 1399* Ryu, G ...... 2334 Sasayama, Y ...... 1315 Roberts, J R ...... 1042, 1057, Rosenspire, A J ...... 1176* Ryu, H ...... 2010 Sasseville, V G ...... 752, 757* ...... 1058*, 1059 Rosenstein, M ...... 998 Ryu, J ...... 1076 Sathishkumar, K ...... 1190, 1384* Roberts, K N ...... 1601 Rosenthal, G J ...... 1688 Rzigalinski, B ...... 1468 Sato, H ...... 1749, 2043, 2128* Roberts, R ...... 1127* Rosenzweig, B ...... 125 Sato, J ...... 2280 Roberts, R R ...... 1223 Rosenzweig, B A ...... 124*, 1667, 2393 Sato, K ...... 61, 67, 2110 Roberts, S ...... 1562 Rosier, R N ...... 365, 1376 S Satoh, M ...... 2023 Roberts, S M ...... 31*, 409, 410*, Ross, A ...... 121* Saavedra, G ...... 470* Satoh, T ...... 167, 2442 ...... 1631, 1900 Ross, D ...... 1099 Sabitsana, P ...... 1534 Satomi, Y ...... 1378* Roberts-Kirchhoff, E S ...... 1658 Ross, J H ...... 1261*, 2287 Sabnis, A S ...... 1385* Sattabongkot, J ...... 1712 Robertson, D ...... 1859, Ross, M K ...... 694*, 862, 1202, 1825 Sabourin, C L ...... 1921 Satterfield, B ...... 606 ...... 2227*, 2229* Ross, P ...... 1616 Sabourin, P J ...... 1921 Satterstrom, K F ...... 1639 Robertson, D G .... 165, 173, 623, 1678 Ross, S ...... 1364 Sabri, M ...... 2426* Satterwhite, C M ...... 1740*, 1741 Robertson, J D ...... 341*, 342*, 2009 Rossier, S ...... 42 Sacaan, A ...... 993 Sauer, P ...... 384 Robertson, L ...... 1542 Rossman, T G ...... 760* sace, f ...... 2343 Saulsbury, M D ...... 1211* Robertson, L W ...... 588, 1221 Rossomando, A ...... 608 Sachan, A ...... 2288 Saunders, G K ...... 136 Robinette, B L ...... 1430, 2414* Roszell, L E ...... 2069* Sadhu, D N ...... 550* Savage, D D ...... 1793 Robinson, D ...... 1854*, 1859 Roter, A ...... 987 Sadler, C ...... 1222 Savery, L C ...... 545* Robinson, E J ...... 540 Roth, B ...... 2222 Sadovova, N ...... 126* Savolainen, K ...... 372* Robinson, J ...... 898 Roth, D R ...... 788 Sadri, B ...... 159 Sawabe, Y ...... 1614 Robinson, J F ...... 445* Roth, M D ...... 802 Safe, S ...... 209, 358, 948, Sawada, H ...... 1620* Robinson, K ...... 611, 612 Roth, R A ...... 97, 999, ...... 1155*, 1157, 1324 Sawada, J ...... 702, 1333 Robinson, P ...... 69 ...... 1002, 1005, 1708, Safe, S H ...... 1102 Sawant, S ...... 1967 Robinson, P J ...... 2367* ...... 1710, 1711, 1718, Safe, T M ...... 1449* Sawant, S G ...... 555* Robinson, S ...... 796, 859 ...... 1905, 2148, 2224* Safe, S ...... 951 Sawant, S P ...... 467, 1008* Robinson, V ...... 1046* Roth, T ...... 1634*, 2324 Safford, R J ...... 2275 Sawazaki, T ...... 204 Robison, C L ...... 78 Rothbauer, D C ...... 879 Safirstein, R ...... 164 Sawyer, J R ...... 536 Robison, S W ...... 1260* Rothe, H ...... 2262* Sager, S ...... 583, 585 Saxena, A ...... 69 Robles, M R ...... 482* Rothenberg, S J ...... 863* Saghir, S A ...... 685* Sayes, C M ...... 823, 825, 1554* Robosky, L C ...... 165, 173, 623 Rothermund, C A ...... 1430 Sahlberg, B ...... 872* Scallet, A ...... 126 Robson, M G ...... 1571 Rothman, N ...... 526 Saito, N ...... 107 Scandlyn, M J ...... 60 up-to-date information at www.toxicology.org 273 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Scarlett, C O ...... 973 Schwerdtle, T ...... 1177*, 1183 Shaw, P J ...... 2148* ...... 1331, 1644, 1822 Schaefer, G ...... 2437 Scinicariello, F ...... 699* Sheabar, F ...... 529 Sikorska, M ...... 1160 Schaefer, G J ...... 665, 737* Sciullo, E ...... 777 Sheasgreen, J E ...... 319 Silbajoris, R ...... 639, 1014 Schafer, G ...... 736 Sciuto, A M ...... 79, 1035 Sheehan, P ...... 850 Silber, P ...... 689, 2017 Schallert, T ...... 1103 Scollon, E J ...... 569* Sheen, Y Y ...... 1959 Silbergeld, E K ...... 284, 1175*, Schantz, S L ...... 1453 Scott, A ...... 2021 Sheets, L ...... 50 ...... 1611, 1776 Scharf, B ...... 1774* Scott, C S ...... 2302 Sheets, L P ...... 49*, 1528 Silkworth, J ...... 1540, 1541* Schatz, R A ...... 1804, 1823 Scott, P ...... 561, 1254, 1536 Shen, J ...... 483, 2040* Sillanpaa, M ...... 239, 1193 Schauer, U ...... 598 Scott, P K ...... 857 Shen, L J ...... 250* Silva, M J ...... 2113* Schauer, U M ...... 604* Scott, R C ...... 1386 Shen, M ...... 526 Silver, K ...... 1482*
AUTHOR INDEX AUTHOR Schauer, W ...... 1688 Scotto, J ...... 73, 80 Shen, S X ...... 845 Silverman, L ...... 2423* Schebler, P J ...... 594* Scotto, J A ...... 72 Shen, Y ...... 807* Simeonova, P P ...... 1555 Schecter, A ...... 1197 Scrafford, C G ...... 2180 Sheng, T ...... 1322 Simmen, F A ...... 1368, 2401, 2403 Schecter, A J ...... 90, 1544* Scudamore, C ...... 2021*, 2153 Shenton, J ...... 101 Simmonds, J ...... 859 Scheffer, G ...... 1006 Sczymczuk, C ...... 1724 Shepherd, D M ...... 1380, 1397 Simmons, B ...... 627 Scheffer, G L ...... 202 Seagle, C M ...... 2144 Sherman, C D ...... 113, 122, 899 Simmons, J ...... 157, 2299* Scheffler, B E ...... 1879 Seagrave, J ...... 241, 1201*, 2212 Sherman, J ...... 1232 Simmons, J E ...... 1268 Scheffler, H ...... 1588, 2262 Seah, Q ...... 1712 Sherr, D ...... 670 Simmons, R ...... 2234* Scheiner, M ...... 2085 Seaman, C W ...... 1299, 2276* Sherr, D H ...... 1726, 2010 Simmons-Willis, T A ...... 2067 Schell, J ...... 876 Seaman, V ...... 1705* Shertzer, H G ...... 501, 931, 1810 Simms, C ...... 1681, 1682 Schenk, S ...... 1086 Searfoss, G ...... 199 Sherwood, S O ...... 2144 Simpson, C D ...... 229 Schiestl, R ...... 535, 549 Searfoss, G H ...... 1527*, 2392 Sheth, C M ...... 267* Simpson, D ...... 652 Schiestl, R H ...... 528, 537, 538, Seawright, A A ...... 845*, 2086 Shetty, G ...... 1547 Sin, J ...... 269 ...... 977, 1643* Sebelova, J ...... 1806 Sheu, T ...... 1376 Sinanaj, Q ...... 2178 Schijf, M ...... 373 Secretan, B ...... 385 Shi, D ...... 1115 Sinclair, J F ...... 1004 Schilling, B ...... 982, 2089, 2095 Seegal, R F ...... 1100 Shi, L ...... 1888 Sinclair, P R ...... 1004 Schilling, C ...... 867* Seeley, M ...... 2181* Shi, L Z ...... 1096* Singh, A K ...... 1578* Schins, R ...... 1193 Seely, J C ...... 1242 Shi, P ...... 2118 Singh, D V ...... 969 Schladweiler, M ...... 2173 Segal, D J ...... 2074 Shi, S T ...... 964* Singh, J ...... 620* Schladweiler, M C ...... 240, 1062, Segarra-Arroyo, A ...... 1778* Shi, X ...... 1512* Singh, M ...... 177, 840, 1591* ...... 1063, 1194, 2411 Segura, B ...... 1798 Shi, Y ...... 1989* Singh, N P ...... 1895* Schlag, R ...... 109 Seidel, S ...... 1084* Shibahara, Y ...... 1421 Singh, R ...... 512 Schlager, J ...... 830, 2361 Seidler, F J ...... 1439*, 1440 Shibata, A ...... 204 Singh, R K ...... 2033*, 2039 Schlager, J J ...... 37, 841, Seiler, A ...... 142 Shibata, E ...... 2434 Singhal, R ...... 1651* ...... 1559, 1723, 2200 Seki, N ...... 2110 Shibutani, M ...... 57* Sipes, G ...... 2149 Schlechter, K ...... 142 Sekowski, J W ...... 80* Shibutani, S ...... 554 Sipes, I ...... 592, 593, 1550 Schleef, R ...... 301, 309 Seldin, D ...... 670 Shields, W J ...... 2199 Sistare, F ...... 1854 Schleier, J ...... 1585 Selgrade, M ...... 2257 Shigeyama, T ...... 2154 Sistare, F D ...... 296 Schlezinger, J ...... 1726* Selgrade, M K ...... 374, 2196, Shih, D ...... 1548 Sistrunk, S C ...... 1486, 1487 Schlezinger, J J ...... 2010 ...... 2252, 2258 Shih, T ...... 78 Sivaraman, S K ...... 2130 Schlosser, P M ...... 2372 Selstam, G ...... 2025 Shih, T A ...... 68 Siwkowski, A ...... 602 Schlosser, W ...... 2320 Senba, T ...... 1704 Shiizaki, K ...... 83 Sizemore, A ...... 1968, 1970 Schlumpf, M ...... 1928 Senekeo-Effenberger, K ...... 1323 Shimada, A ...... 1048* Sjogren, B ...... 2303 Schmeiser, H H ...... 790 Sengupta, A ...... 1757 Shimbo, S ...... 107 Skebo, J ...... 2361 Schmid, J E ...... 932 Sens, D A ...... 2033, 2038*, Shimizu, K ...... 1213 Skinner, C M ...... 2401 Schmidt, R ...... 2340 ...... 2039, 2041, 2042, 2081 Shimizu, T ...... 108, 1077* Skinner, M ...... 1860, 1862* Schmieder, P ...... 2295 Sens, M ...... 2033, 2038, 2039, Shimomura, Y ...... 1704 Skop, M ...... 1981 Schmitt, M T ...... 645* ...... 2041, 2042, 2081* Shin, J ...... 605, 2054 Skotak, M ...... 2332 Schnackenberg, L ...... 125, 164, 2142 Seo, E ...... 581 Shines, C J ...... 1053 Slater, T ...... 1859 Schnackenberg, L K ...... 158* Seog, D ...... 1719 Shinohara, A ...... 2043* Slatter, G ...... 1692 Schneider, J ...... 1845* Seok, J ...... 401 Shioda, S ...... 1427, 1460 Slawik, B ...... 142 Schneider, J S ...... 1846 Seraphides, N ...... 2293 Shiotani, M ...... 654* Slayton, T M ...... 2305 Schneider, L ...... 2260* Serikawa, K ...... 1647 Shiotsuka, R N ...... 1247 Slikker, W ...... 126, 2232 Schneider, M C ...... 423 Serizawa, K ...... 2043 Shipp, A M ...... 2296, 2307* Slim, R M ...... 1737 Schneider, S ...... 1432* Serle, J ...... 2432 Shipp, B K ...... 1284* Slitt, A ...... 1366 Schneider, S N ...... 2024* Serrano, J ...... 1941* Shirai, N ...... 1315 Sloan, C S ...... 1242 Schnekenburger, M ...... 1377* Sette, W ...... 1425 Shirai, T ...... 962, 1421, 1423, 1642 Slotkin, T A ...... 1439, 1440 Schnell, D ...... 580 Settivari, R S ...... 1404* Shishido, N ...... 1530 Smallwood, C ...... 2294* Schnellmann, R G ...... 456, 461 Setzer, R W ...... 2284, 2285* Shlionska, A ...... 988 Smart, E ...... 91 Schoen, A ...... 759, 2186* Setzer, W ...... 46 Shnaider, D ...... 1729* Smart, R C ...... 59, 1362 Schoen, D ...... 1604 Seung, H ...... 1618, 1619* Shock, S S ...... 2188*, 2199 Smartt, A ...... 1092 Schoenfelder, G ...... 703* Sevastyanova, O ...... 1257 Shockley, E E ...... 1925 Smialowicz, R ...... 135 Schofield, J ...... 652, 1533*, 2168 Sexton, K G ...... 1060*, 1065, Shoemaker, J A ...... 371 Smith, A G ...... 512, 796* Scholten, D ...... 1174 ...... 1702, 2214* Shoemaker, R H ...... 991 Smith, C ...... 1285, 2198*, 2368 Scholz, B ...... 368 Sexton, M ...... 699 Shoen, D ...... 864 Smith, C L ...... 984 Schomaker, S ...... 1684, 2016 Sey, Y M ...... 1208* Short, B ...... 328 Smith, C S ...... 594 Schomaker, S J ...... 679* Shafer, T J ..... 1480, 1481, 2430, 2431* Short, B G ...... 3* Smith, C V ...... 123*, 2351 Schott, K ...... 1252 Shaffer, S ...... 1437 Shost, S J ...... 2432 Smith, D ...... 188, 1765 Schramm, C ...... 376 Shah, I ...... 162* Showalter, L A ...... 1225 Smith, D R ...... 1764, 2062 Schramm, U ...... 614 Shah, M ...... 1800 Shubat, P ...... 895 Smith, E ...... 1783 Schroeder, J F ...... 551 Shaha, A ...... 2103* Shuler, M L ...... 320* Smith, J P ...... 1304 Schroeter, J D ...... 2125* Shaikh, N ...... 588 Shuttlesworth, G A ...... 1547 Smith, J R ...... 1397 Schuessler, T F ...... 805* Shakarjian, M P ...... 831 Shutz, M ...... 1924 Smith, K R ...... 240* Schuh, R ...... 1111* Shakir, S ...... 421 Shvedova, A ...... 1555 Smith, M A ...... 453, 1993 Schultz, A ...... 1845 Shamy, M Y ...... 1768 Shvedova, A A ...... 846, 1163, Smith, M P ...... 623 Schultz, I R ...... 2375 Shan, Y A ...... 594 ...... 1556, 1557* Smith, M R ...... 525 Schulz, S ...... 1924 Shankar, K ...... 2401* Sicilia, T ...... 506* Smith, M T ...... 526, 981, 1997 Schulz, S M ...... 81 Shao, B ...... 2434 Sickles, D ...... 2424*, 2425, 2426 Smith, M V ...... 1890, 2376 Schulze, J ...... 1295*, 1882* Shao, J ...... 966 Sidaway, J E ...... 1386* Smith, N ...... 2286 Schulze, M ...... 1882 Shapira, I ...... 1910 Siddiqui, W H ...... 1239*, 1240 Smith, N B ...... 794 Schumacher, K ...... 1425, 1428 Shaputnic, C ...... 1262 Sidhu, J S ...... 445 Smith, P J ...... 1188 Schussheim, Y ...... 1910 Shara, M ...... 1420* Sidorov, I A ...... 991, 2120 Smith, S M ...... 143, 144 Schutte, K ...... 1594* Sharma, N ...... 1394, 1395 Sieber, S O ...... 1081 Smith, S Y ...... 446 Schwab, C ...... 325, 1899 Sharma, R P ...... 1394, 1395* Siegel, D ...... 110 Smith, W J ...... 1914 Schwanekamp, J A ...... 783* Sharp, J ...... 49, 50 Siegel, D M ...... 729* Smith-Roe, S L ...... 514* Schwartz, B S ...... 51, 335, 337* Sharpe, R ...... 926 Siegel, P D ...... 379 Snell, M ...... 1000 Schwartz, C S ...... 1284 Sharper, V ...... 133 Siegers, C ...... 1295, 1882 Snellings, W M ...... 463 Schwartz, S ...... 1416 Shatkin, J ...... 897 Siekerka, J ...... 293 Snyder, D ...... 40 Schwarz, E M ...... 365, 1376 Shaw, G R ...... 845 Sierra, M ...... 1262 Snyder, R ...... 295, 2235 Schwegler-Berry, D ...... 1557 Shaw, M ...... 457, 534, 619 Sierra-Santoyo, A ...... 62, 590*, Snyder, R D ...... 1358, 1858*
274 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Snyder, R W ...... 166 Statom, G ...... 584 Stuckey, R ...... 1931 T Sobel, E S ...... 1900 Stauber, A J ...... 290* Stump, D G ...... 6*, 936, 1236, 1239 Tabo, M ...... 1530 Sobol, Z ...... 535, 537, 977* Stauber, J ...... 2065 Stutz, J ...... 199 Tager, I B ...... 1139* Sobry, C ...... 1859 Stayner, L T ...... 349 Styblo, M ...... 412, 413, 426, Taggart, P ...... 789 Soelberg, J J ...... 583, 585* Stearns, D M ...... 2048, 2073, 2074 ...... 440, 443, 2356 Taguchi, K ...... 480* Soelle, D ...... 986* Stebbins, K E ...... 463 Su, H ...... 1834 Tahara, M ...... 1213 Solansky, I ...... 1257 Steele, B L ...... 1241 Su, S ...... 191 Tahara, T ...... 1704 Soldin, O ...... 1775 Steen, A ...... 2339 Subramaniam, K ...... 308 Takacs, M L ...... 195* Soliman, M R ...... 2433 Steen, D ...... 1307 Subramaniam, R ...... 894 Takada, S ...... 458 Solipuram, R ...... 404 Steevens, J ...... 1564 Suchankova, Z ...... 1257 Takagi, A ...... 155*, 2128 Solis-Heredia, M ...... 2108 Steevens, J A ...... 786 Suda, M ...... 1451, 2109 Takahara, T ...... 83 Solomon, S E ...... 670* Steffy, D A ...... 1586 Sudo, K ...... 1621 Takahashi, N ...... 1704 Soloviev, M V ...... 653* Steger-Hartmann, T ...... 142 Sudo, T ...... 2140 Takahashi, S ...... 1642 Solyom, A M ...... 592, 593*, 675 Stehfest, E ...... 637 Suer, L ...... 855 Takami, K ...... 1094, 1620 Somayajulu, M ...... 1160 Steinetz, B G ...... 928 Sugai, M ...... 2166 Takami, S ...... 1996 Somers-Edgar, T ...... 1399 Stelcer, E ...... 2063 Suganuma, A ...... 167 Takamura-Enya, T ...... 790 Somji, S ...... 2033, 2038, 2039, Stemmer, K ...... 447* Sugimoto, H ...... 469 Takashima-Sasaki, K ...... 1987* ...... 2041*, 2042, 2081 Stephani, R A ...... 607* Sugita-Konishi, Y ...... 275* Takasuga, T ...... 108 Sommersted, K ...... 259* Stephens, R M ...... 991 Sugiura, S ...... 962, 1642 Takebayashi, T ...... 877 Sommerville, D R ...... 72, 77, 1925* Stephenson, A P ...... 1762 Sujjavanich, D N ...... 1418* Takeda, K ...... 83 Somps, C ...... 620 Stern, B R ...... 2312* Sukata, T ...... 1228 Takenaka, K ...... 107, 108 Somsamayvong, B ...... 78 Sterner, T R ...... 1279 Sulentic, C E ...... 1725, 1730*, 1731 Takeshita, T ...... 107 Son, S ...... 791, 2268 Stevens, G ...... 1668, 1808, Sulik, K K ...... 139 Takeshita, K ...... 1642* Sonawane, B ...... 1635 ...... 1908, 1909 Sullivan, D ...... 2182 Takeuchi, Y ...... 2434 AUTHOR INDEX Sone, H ...... 1891 Stevens, G J ...... 159, 627, 631, 1314 Sullivan, J M ...... 628, 629 Takita, T ...... 275 Sone, S ...... 1530 Stevens, J ...... 199 Sullivan, K A ...... 1760* Tal, T ...... 1513 Song, C ...... 1049, 1794 Stevens, J L ...... 289 Sullivan, L ...... 1027* Tal, T L ...... 1014* Song, J ...... 1693 Stevens, S ...... 1664, 2421* Sullivan, M ...... 213, 2189* Tamaki, Y ...... 936, 1236 Song, M ...... 1181* Stevens, S C ...... 841* Sultatos, L G ...... 1215 Tamano, S ...... 1421 Song, Y ...... 354 Stevens, T ...... 249* Summers, C ...... 2135 Tan, Y ...... 1271, 1337*, 1875, Soni, M G ...... 1151* Stevens, V L ...... 1495* Sumner, S C ...... 166 ...... 1885*, 1886, 1888, 2310 Soni, N ...... 375 Stewart, B ...... 2404* Sumpter, J ...... 2245 Tan, Z ...... 215* Soni, N K ...... 2265 Stewart, G ...... 606 Sun, F ...... 2008* Tanaka, A ...... 1055 Sonich-Mullin, C ...... 1636, 1926 Stewart, I ...... 845 Sun, G ...... 957 Tanaka, S ...... 573*, 576, 2385 Sono, S ...... 2279 Stewart, J A ...... 234 Sun, H ...... 346, 1372* Tanaka, Y ...... 1349* Soo Jin, H ...... 85* Stickney, J ...... 382, 2306 Sun, J ...... 291 Tang, D G ...... 343* Sopori, M ...... 76 Stidley, C ...... 1201 Sun, L ...... 662 Tang, L ...... 176, 957 Sordo, M ...... 1354 Stigson, M ...... 368* Sun, N N ...... 1722* Tang, M ...... 1642 Sorensen, S ...... 48 Stinn, W ...... 309 Sun, Q ...... 1196, 1197 Tang, Y ...... 957, 2434 Sorenson, J ...... 237 Stirling, D ...... 133 Sun, S ...... 865 Tanguay, R L ...... 38, 145, 222, Sorokina, S ...... 668 Stocker, J W ...... 618 Sun, T ...... 1683 ...... 223, 1120*, 1210 Sorrentino, C ...... 354, 787* Stohs, S J ...... 1979 Sun, X ...... 2152 Tanhehco, E ...... 664 Soshilov, A ...... 354, 356* Stoker, T ...... 1948 Sun, Y ...... 2434 Taniguchi, K ...... 1620 Soto, A ...... 170 Stoker, T E ...... 1166* Sundaram, S K ...... 2349 Taniguchi, R ...... 2128 Soucy, N V ...... 168*, 441, 646 Stokes, W ...... 906, 1969, 1970 Sung, J ...... 2064 Tanimoto, T ...... 1652 South, N L ...... 2363 Stokes, W S ...... 907, 908*, 909, 1968 Sung, J H ...... 1752 Tannehill-Gregg, S ...... 2089* Souza, V ...... 2035 Stolper, G ...... 44* Sunouchi, M ...... 702 Tanner, A E ...... 137 Sparatore, A ...... 2136 Stolz, D B ...... 441 Suresh, B ...... 1985 Tannert, T R ...... 2410 Sparrow, C R ...... 1189 Stone, H ...... 1922 Suresh, C ...... 1787 Tanphichai, K ...... 2131 Spear, B T ...... 1221 Stone, P ...... 641, 1365 Sussman, G ...... 379 Tarantino, L M ...... 1039* Spearow, J L ...... 2111 Stone, S ...... 1057 Susumu, T ...... 667 Tarantino, P ...... 2165 Speed, A R ...... 1626 Stonehuerner, J D ...... 1051 Suter, L ...... 203 Tardif, R ...... 565, 1273 Speer, D P ...... 817 Stoner, G D ...... 958, 1648 Sutherland, K M ...... 647*, 803 Tarlo, S M ...... 1839* Speer, M ...... 1493* Stonerook, M ...... 2176 Sutter, T R ...... 1540 Tarloff, J B ...... 485, 487 Spencer, A G ...... 201 Stonerook, M J ...... 1304* Sutton, R ...... 2000 Tashkin, D P ...... 802 Spencer, P ...... 2426 Storer, R D ...... 332* Suzen, S ...... 697 Tay, J ...... 1772 Spencer, P J ...... 556, 889*, 1524* Stork, L G ...... 1627* Suzuki, A ...... 2154 Taya, K ...... 1652 Spiegl, N M ...... 700* Storm, J E ...... 2432* Suzuki, H ...... 936, 1091*, Taylor, A ...... 2063, 2065 Spielmann, H ...... 142 Stott, W T ...... 2323* ...... 1236, 1394*, 1395, Taylor, B F ...... 417*, 418 Spiers, D E ...... 1404, 1405 Stouch, B ...... 1691 ...... 2279, 2281, 2282 Taylor, G ...... 1053 Spiess, P ...... 490* Stoutamire, D ...... 1518 Suzuki, K T ...... 458 Taylor, J B ...... 1629* Spirkl, H ...... 522 Stoyanovski, D ...... 1158 Suzuki, M ...... 2283* Taylor, J F ...... 871, 1577* Spivey, C L ...... 1477, 1479 Stoyanovsky, D ...... 1163 Suzuki, S ...... 962 Taylor, J K ...... 1950 Sponenberg, D P ...... 136 Stradella, O ...... 753 Suzuki, T ...... 2140 Taylor, J T ...... 2395 Springer, D L ...... 183* Straif, K ...... 385 Suzuki, Y ...... 206 Taylor, M ...... 2286 Springs, A E ...... 266* Strakhova, M ...... 1546 Sved, D W ...... 935 Taylor, R T ...... 228* Squibb, K S ..... 700, 2071*, 2072, 2082 Stralka, D ...... 855* Svedberg, U ...... 2303* Taylor, S ...... 2150 Sram, R J ...... 1257 Stratmeyer, M ...... 2339 Svensson, M ...... 2025 Tchao, R ...... 2408, 2409 Srivastava, S ...... 297 Stratmeyer, M E ...... 1560 Svoboda, K R ...... 1120 Tcholakov, I ...... 1668 Staal, Y C ...... 2218 Stratton, M J ...... 1637* Swain, A ...... 2153 Tchounwou, P B ...... 517 Stachlewitz, R F ...... 1708, Straub, A C ...... 441* Swalsky, P A ...... 979 Teeguarden, J G ...... 2127* ...... 1711, 1905 Straube, F ...... 1716 Swanson, H I ...... 210 Teeguarden, J T ...... 2308 Staedtler, F ...... 141, 788 Strauss, K ...... 2082 Swanson, K J ...... 235* Telman, J ...... 896 Stagliola, E M ...... 1823* Streicker, M ...... 1666 Swanson, S ...... 1645 Temple, A ...... 1679* Stahl, T ...... 516 Strickland, J ...... 1969, 1970 Swartz, C ...... 513 Temple, B ...... 973 Staines, W A ...... 1975 Strickland, J A ...... 1968* Sweeney, L M ...... 2301* Temple, W ...... 2286 Stammberger, I ...... 522, 619 Strittmatter, E F ...... 183 Sweeney, T ...... 1037 Tenhoor, C ...... 132 Stamp, C ...... 2153 Strom, S ...... 2138 Sweet, C J ...... 593 Tennant, R ...... 1000, 1616 Stang, B ...... 1656 Strom, S C ...... 1815 Swenberg, J A ...... 187, 330*, 973 Tenneson, K ...... 1289* Stanko, J P ...... 1204* Strong, A ...... 1589 Swett, D ...... 1724 Teo, S ...... 133 Stanley, J K ...... 1583*, 2247 Stropp, G D ...... 1242 Sykes, G ...... 1055 Teodoro, J ...... 1713* Stapelton, P L ...... 1815 Strother, D E ...... 1232, 1235 Sykes, G P ...... 2326 Teranishi, M ...... 206, 2272 Stapleton, A R ...... 170 Stroup, J ...... 1528 Sylvia, C ...... 1037 Teraoka, H ...... 1120 Stapleton, P ...... 966 Struble, C ...... 394 Syversen, T ...... 1775, 1780, Terasaki, N ...... 1949* Starr, J M ...... 569 Strupp, C ...... 1716* ...... 1785, 1846, 2066* Terneus, M ...... 1009* Starr, T B ...... 383 Struve, M F ...... 1294* Szakacs, J G ...... 1004 Teske, S ...... 1898* Staskal, D ...... 596*, 1169 Stuart, E C ...... 60* Szapacs, M E ...... 509* Tessari, J ...... 1217 Staskal, D F ...... 562 Stuchal, L D ...... 1935 Szilagyi, M ...... 1121 Tessari, J D ...... 597, 2370 States, J ...... 21, 417, 418, 520, Stuckey, J ...... 256, 1581* Tessier, D M ...... 2050* ...... 792, 799, 800, 1370 Stuckey, J A ...... 1462, 1463 Testino, A ...... 2424, 2425*, 2426 up-to-date information at www.toxicology.org 275 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Teuschler, L ...... 1627 Toader, V ...... 1645 Tsutsui, N ...... 1949, 2250 van Breda, S G ...... 2218 Teuschler, L K ...... 1274 Tobia, A J ...... 1872* Tucker, A ...... 1654 van Bree, L ...... 1198 Tewksbury, E W ...... 1697 Tobias, J ...... 696* Tucker, C J ...... 1081 van de Sandt, H ...... 1902 Thai, S ...... 432, 1206, 1229 Tobin, J ...... 589 Tudor, G ...... 991 van den Berg, M ...... 1174, 1457, Tharappel, J C ...... 1221* Tobin, J M ...... 1929 Tufariello, E M ...... 1610 ...... 1543, 1951 Thatcher, G R ...... 1645, 2163 Toborek, M ...... 91, 305 Tugendreich, S ...... 169, 987 van der Merwe, D ...... 812* Thayer, W ...... 1926* Toda, Y ...... 1423 Tukey, R H ...... 778, 1323, 1807 van Duursen, M B ...... 1951* Thayer, W T ...... 858 Todaka, E ...... 1614 Tukov, F F ...... 1718* van Herwijnen, M H ...... 2218 Theberge, M ...... 2390 Todd, D ...... 1664 Tung, E W ...... 154* Van Houten, B ...... 741, 744* Theerayuth, K ...... 1048 Todd, G ...... 2298 Tung, K ...... 90, 1544, 1999 van Landingham, C ...... 894*, 2307
AUTHOR INDEX AUTHOR Theodorakis, C ...... 1191 Todd, M ...... 171 Tungla, E B ...... 1977* Van Landingham, C B ...... 1280 Theusch, J ...... 1663 Todd, M D ...... 1675* Turpaz, Y ...... 2393 van Leeuwen, D M ...... 2218 Thibaudeau, K ...... 624 Todoriki, H ...... 107 Turton, J ...... 2153 Van Loveren, H ...... 281, 1896 Thibodeaux, J R ..... 370, 399, 576, 932 Todorov, T ...... 2071 Tuukkanen, J ...... 1680 Van Miller, J ...... 1232 Thiex, N W ...... 1553 Tohkin, M ...... 1333 Twaroski, M L ...... 905 Van Miller, J P ...... 1242 Thiffault, C ...... 1114* Tohyama, C ...... 83, 1539, 1749 Tyl, R W ...... 1242* Van Pay, L M ...... 834* Thiruchelvam, M .... 831, 1108*, 1188, Tokado, H ...... 1316, 1694 Tyler, J W ...... 862 van Ravenzwaay, B ...... 586, 1432 ...... 1488, 1802, 2436 Tokar, E J ...... 429* Tyson, C ...... 1962, 1963 van Steeg, H ...... 1896 Thiruchelvam, M J ...... 1484 Tokudome, S ...... 204 Tyurin, V ...... 2005 Van Vleet, T ...... 982* Thoemke, K R ...... 1572, 1573* Tokunaga, H ...... 1213 Tyurin, V A ...... 1158, 1163, Van Winkle, L S ...... 647, 803* Thomas, D J ...... 413, 426, 440, Tollerud, D ...... 876 ...... 2002, 2003* Vancza, E M ...... 1061* ...... 443, 762, 2356 Tolley, A ...... 987, 1889 Tyurina, Y ...... 2005 VanDeMark, K L ...... 1438* Thomas, J ...... 889 Tolson, J K ...... 1610*, 1631 Tyurina, Y Y ...... 1163*, 1557, 2003 Vanden Heuvel, J P ...... 196, 197 Thomas, J A ...... 763*, 764* Tomar, R S ...... 113, 122*, 899 Vandenberg, J ...... 710* Thomas, K C ...... 1164* Tomaszewski, J ...... 1962, 1963 Vandenberg, J J ...... 983, 2311 Thomas, K T ...... 1744 Tomaszewski, J E ...... 2, 322*, 595 U VandenBerg, M ...... 1171 Thomas, P ...... 952 Tomazic-Jezic, V J ...... 1560* Ubayawardena, R ...... 1376 Vandenbergh, J G ...... 405 Thomas, P E ...... 1322 Tomczuk, M ...... 984 Uchino, H ...... 1670 VandenHoek, S ...... 1975 Thomas, R ...... 1353, 1654 Tomic, D ...... 392* Uchiyama, I ...... 693, 798 Vanderklok, C ...... 2174 Thomas, R D ...... 2114 Tominaga, Y ...... 458 Ueda, H ...... 1704 VandeVoort, C A ...... 2107 Thomas, R F ...... 1063*, 1194 Tomlinson, C R ...... 783 Uehara, S ...... 108 Vansant, G ...... 553* Thomas, R S ...... 2093* Tomlinson, L ...... 2089 Uehara, T ...... 1079* Vargas, G ...... 291, 521 Thomas, S M ...... 534 Tompkins, L M ...... 1328* Ueng, T ...... 1820* Varney, M ...... 1036 Thompson, B N ...... 615 Ton, C ...... 39, 1535* Ulland, B ...... 2095 Varney, M R ...... 1241 Thompson, C ...... 1300*, 1615* Tong, W ...... 835, 2142 Ulleras, E ...... 1173 Varshavsky, J R ...... 1564 Thompson, C B ...... 1219 Tonkin, E ...... 1075* Ullmann, L G ...... 888, 2319 Varsho, B J ...... 936, 1236* Thompson, C M ...... 2311 Toops, K A ...... 367 Ulreich, J B ...... 817* Vasconcelos, D ...... 1923 Thompson, D ...... 1241 Topinka, J ...... 1257* Ulrey, A K ...... 912* Vasconcelos, D Y ...... 1422 Thompson, E A ...... 59* Torikai, Y ...... 1670, 2154* Ulrich, H ...... 822 Vasiliou, V ...... 366, 468* Thompson, J T ...... 196 Toriumi, W ...... 492 Ulrich, R G ...... 201, 1692, 2226* Vasold, R ...... 822 Thompson, K ...... 124, 125, Torky, A W ...... 637 Ultman, J S ...... 1135* Vasquez, M ...... 2313 ...... 1751*, 2393 Tornero-Velez, R ...... 2365 Umbreit, T H ...... 1560 Vassallo, J D ...... 1590* Thompson, K L ...... 1667 Tornesi, B ...... 2323 Umbuzeiro, G A ...... 2084 Vassiliou, V ...... 2293 Thompson, M J ...... 1241 Torontali, S ...... 402 Umemura, T ...... 119, 972*, 978 Vasudevan, C ...... 493* Thompson, R ...... 1277 Torontali, S M ...... 1551 Unfricht, D ...... 265 Vaughan, R ...... 1030* Thomson, S ...... 69, 73, 74, Torres, K ...... 1676 Unice, K ...... 849, 1254 Vazquez, I L ...... 540 ...... 75, 80, 1033 Torres, S ...... 2161 Unice, K M ...... 857 VD Horst, L ...... 48, 930 Thomson, S A ...... 68, 70, 71, 72, 77 Torres, S M ...... 971* Unis, D ...... 939 Vedal, S ...... 708* Thorpe, J E ...... 421 Torres Sanchez, L ...... 863 Unkila, M ...... 2335 Vedula, U ...... 1626 Thorsrud, B ...... 134 Torres-Vega, A ...... 112, 280 Uno, H ...... 865, 1023*, 2031 Vega, K ...... 1981 Thrall, K D ...... 583, 585, 591, 1519* Toscano, C D ...... 2413* Uno, S ...... 1810 Vekaria, H ...... 2085 Threadgill, D ...... 316*, 1616 Toselli, P ...... 641, 1365 Upham, B L ...... 61, 66*, 67, 961 Vemuri, M C ...... 1787 Threadgill, D W ...... 194 Toshimori, K ...... 925 Uppu, R M ...... 1189*, 1190, 1384 Vengellur, A ...... 2034* Thuett, K A ...... 1782* Totura, A L ...... 70 Urbach-Ross, D ...... 1115* Vera, R ...... 521 Thukral, S ...... 1534, 1662 Tourous, D ...... 546 Urban, J D ...... 1374* Veranth, J M ...... 240, 242* Thummel, K E ...... 1815 Tovar-Sanchez, E ...... 2076 Urda, E ...... 2138 Veranth, M M ...... 242 Thurberg, B ...... 175 Toyama, Y ...... 925 Urgino, J ...... 1534 Verdin, E ...... 1997 Thuy, C ...... 1177, 1183 Toyoshiba, H ...... 1891* Uribe-Querol, E ...... 1769 Vergel de Dios, J ...... 1160 Thyagarajan, R ...... 293 Tracey, H A ...... 821 Uribe-Ramirez, M ...... 1184 VerHoeve, J ...... 1085 Thyparambil, S ...... 2395 Tracy, J H ...... 1815 Urushidani, T ...... 186, 1077, 1078, Verhoeven, S ...... 997 Tian, Y ...... 1322, 1330 Tran, H T ...... 2372 ...... 1079, 1080, 1709 Verkouteren, J ...... 347, 351* Tibbetts, B ...... 584 Tran, L ...... 1307 Urusidani, T ...... 989 Verma, N ...... 177 Tibbitts, J ...... 134 Trauth, S ...... 2162 Usuka, J ...... 548 Verma, P ...... 381 Tice, R ...... 906, 1969, 1970 Travlos, G ...... 1671* Uwagawa, S ...... 1228 Vermeulen, R ...... 526 Tice, R R ...... 907, 908, 909*, 1968 Trease, L L ...... 35 Vernon, H ...... 1296, 1298, 1617 Tien, E ...... 1326* Treinen-Moslen, M ...... 2136, 2139 Veronesi, B ...... 513 Tiesman, J ...... 402 Treuter, E ...... 360, 361 Verwei, M ...... 1902 Tiesman, J P ...... 1551 Triff, K ...... 1933* V Veselica, M M ...... 1242 Tietge, J ...... 1941 Tritscher, A ...... 2206* V D Hoeven, J ...... 1971 Vesper, S J ...... 371 Tietge, J E ...... 1572, 1573, 1942 Trivedi, A ...... 1965 Vachalkova, A ...... 515 Vezina, C ...... 923*, 924 Tiffany-Castiglioni, E ...... 339*, 1782 Trombetta, L D ...... 1485, 1579, 1774 Vachon, S ...... 1293 Vezina, C M ...... 95, 781 Tiffany-Castiglioni, E C ...... 335 Trommer, W E ...... 614, 1716 Vaddi, K ...... 1740 Vezina, M ...... 1288, 1289, Tigner, J C ...... 610, 611, Troncy, E ...... 582, 1287 Vaghjiani, R J ...... 2047 ...... 1290*, 1310 ...... 612, 1531* Trosko, J E ...... 61, 66, 67, 961 Vahey, M ...... 80 Viant, M ...... 160 Tikly, M ...... 533 Truax, J ...... 906 Vaidya, V ...... 125 Viau, A ...... 1292, 1695 Tillander, S ...... 372 Truax, J F ...... 908, 909 Vaidya, V S ...... 469*, 1663, 1667 Viberg, H ...... 1456* Tilton, F ...... 1120, 1210* Trush, M A ...... 1348 Vakili, Z ...... 1667 Vickers, A E ...... 2357 Tilton, S C ...... 1227* Trute, M ...... 673* Valcour, A ...... 406 Vidair, C ...... 109* Timchalk, C ...... 35, 189, 1515*, 1520* Tsai, Y ...... 1820 Valdes, J J ...... 80 Vijay, V ...... 2288* Timme-Laragy, A ...... 1876 Tsai-Turton, M M ...... 1549* Valdez, R ...... 2016 Vijverberg, H ...... 1457, 1788 Timmins, G S ...... 355 Tsang, A ...... 2379 Valentin, J ...... 652, 1533 Villa, J ...... 541 Tinkle, S S ...... 1039 Tsang, A M ...... 1219 Valentine, R ...... 1275 Villa-Trevino, S ...... 62, 1644 Tinner, B ...... 1975 Tsang, M ...... 1485* Valentino, J ...... 210 Villalobos, A R ...... 1509*, 1772* Tinwell, H ...... 953, 1931 Tseng, H ...... 1834 Valentovic, M ...... 454*, 1009 Villano, C ...... 149*, 833 Tirmenstein, M ...... 1089 Tsuchiya, W ...... 1378 Valenzuela, O L ...... 1256* Villano, C M ...... 151 Tizzano, J P ...... 653, 665, 935 Tsuchiya, Y ...... 458* Vallant, M ...... 1538, 1968, 1970 Villaroman, C P ...... 1610 Tjalkens, R B ...... 1097, 1102, 1759, Tsuji, J S ...... 1258, 2180, Vallee, F ...... 2388, 2389, 2390, 2391 Villeneuve, D L ...... 1565* ...... 1760, 1761, 1947 ...... 2184, 2201* Valles, A V ...... 817 Vinci, T ...... 2176 Tjeerdema, R ...... 160 Tsunoda, M ...... 275, 2442* Vallyathan, V ...... 543, 1046 Vinggaard, A ...... 1945*, 2097 Tjeerdema, R S ...... 1936 Tsushima, Y ...... 1421 Vallyathnan, V ...... 1019 Virgolini, M ...... 1802* van Binsbergen, P ...... 1951 276 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Visan, A ...... 142 Wallerath, T ...... 301*, 309 Wehner, N ...... 252 Williams, A ...... 181, 1961 Vitalone, A ...... 1454* Wallin, S A ...... 1052 Wei, C ...... 1820 Williams, D ...... 2083 Vitsky, A ...... 175, 633 Wallington, A ...... 1956* Wei, M ...... 1228 Williams, D E ...... 1227, 1338 Vladimirov, Y A ...... 2004 Walmsley, R ...... 41*, 1582 Wei, W ...... 1259 Williams, D J ...... 2196 Vladimirova, A ...... 987*, 1358 Walraven, J M ...... 968* Wei, Y ...... 1812, 1833* Williams, G ...... 2083* Vlasova, I I ...... 1158* Walter, I ...... 1183 Wei, Z ...... 1259 Williams, G D ...... 628, 629 Vlasseros, F ...... 446 Walton, F S ...... 440* Weigele, M ...... 993 Williams, G M ...... 303, 616 Vliet, P A ...... 234, 507 Wamer, W G ...... 835 Weiler, H ...... 309 Williams, L D ...... 1993* Vodela, J ...... 2000*, 2203* Wan, J ...... 780*, 945* Weinbauer, G F ...... 1311, 1318, Williams, L H ...... 1655 Voelkel, W ...... 506 Wang, A ...... 1197 ...... 2105*, 2106, 2364 Williams, M ...... 2198, 2298 Voelkel, Y ...... 551 Wang, B ...... 2024, 2030* Weinberg, J ...... 1696* Williams, N A ...... 248*, 285, 286 Voelker, R ...... 2095 Wang, C ...... 126, 1888* Weiner, M ...... 943, 1689 Williams, P L ...... 47 Vogel, C ...... 777* Wang, D ...... 302*, 2164* Weiner, M L ...... 49, 50, 2330* Williams, P R ...... 851*, 852* Vogel, C F ...... 1539 Wang, F ...... 228, 1900* Weiner, R ...... 253 Williams, T ...... 621*, 622, 2153 Vogel, J S ...... 2384 Wang, G ...... 2159 Weinman, S A ...... 1225 Williams, W ...... 135 Vogel, W ...... 733* Wang, H ...... 2434 Weiss, A L ...... 2059* Willis, R ...... 1675 Volsky, D J ...... 1757 Wang, J ...... 176, 185, 536*, 548, Weissert, J L ...... 1804* Willmore, C ...... 69 von Holt, K ...... 301, 309 ...... 957, 1022*, 1191, 1255 Weissman, A D ...... 1976* Wills, T A ...... 139 von Landenberg, F ...... 598 Wang, K ...... 1211 Wejheden, C ...... 89 Willson, T M ...... 965 von Moltke, L L ...... 1004 Wang, L ...... 291, 1646, Wejheden, C I ...... 88* Wilson, B W ...... 785*, 2384 von Recklinghausen, U ...... 416 ...... 1811, 1818, 1879* Welch, R ...... 526 Wilson, C ...... 1654 Von Tungeln, L ...... 1685 Wang, L C ...... 1789 Welham, J ...... 2312 Wilson, D M ...... 463* Vongrises, D ...... 210 Wang, M Z ...... 2441 Weller, D D ...... 599 Wilson, I D ...... 2227, 2230* vonMarrensdorff, H ...... 797 Wang, R ...... 1451, 2109* Wells, D ...... 165* Wilson, M M ...... 979 Vorderstrasse, B A ...... 257*, 1552 Wang, S ...... 957 Wells, D F ...... 173, 623 Wilson, S ...... 357* AUTHOR INDEX Vorhees, C V ...... 931 Wang, T ...... 302 Wells, P G ...... 1434, 1435 Wilson, V ...... 1233 Voss, K ...... 1496 Wang, X ...... 150, 1167*, 1172, Wells, S ...... 245 Wilson, V S ...... 1168*, 1545 Voss, K A ...... 1494*, 1992 ...... 1343*, 1617, 1754* Welsch, F ...... 1244* Wilt, N ...... 559 Voynow, J A ...... 1044 Wang, Y ...... 824, 2091* Welsh, R J ...... 2193* Windman, M ...... 2423 Voytek, P ...... 2301 Wang, Z ...... 957* Welsh, W ...... 54 Wing, M ...... 1592, 1745* Vrana, K E ...... 2419 Wang-Buhler, J ...... 1816, 1834* Welty, S E ...... 123 Winkley, A J ...... 2399* Vu, A ...... 132 Wang-Fan, W ...... 888, 2319* Wen, D ...... 2150 Winn, L M ...... 154, 945, 980 Vu, D ...... 2332 Wanibuchi, H ...... 1228 Wen, L ...... 777 Winnik, B ...... 1484 Vugmeyster, Y ...... 615 Warbritton, A ...... 452 Wen, S ...... 624*, 626, 942 Winnike, J ...... 2093 Vuillemenot, B ...... 1037* Warbritton, A R ...... 829 Wenk, M ...... 1970 Winnike, J H ...... 2144 Vulimiri, S V ...... 557* Ward, D L ...... 136 Wenk, N ...... 1968 Winsett, D W ...... 2173 Vulpe, C ...... 2051 Ward, J B ...... 2355 Werrlein, R J ...... 1917* Winter, H ...... 412 Vulpe, C D ...... 786, 1564 Ward, J M ...... 431, 889, 1321 Wessel, M R ...... 891 Winters, J ...... 1291 Ward, M D ...... 371*, 2257 Wesselkamper, S C ...... 504 Wintz, H ...... 786* Ward, S ...... 1666 Wessely, C M ...... 821* Wipf, P ...... 2002 W Ward, T R ...... 2411 Wessling-Resnick, M ...... 1751 Wise, A ...... 1493 Waalkens, D ...... 48 Ward, W ...... 53, 1229* Westerink, R ...... 1457, 1788* Wise, C K ...... 2129 Waalkens, I ...... 930 Warheit, D B ...... 243*, 1050*, Westmoreland, C ...... 376 Wise, J P ...... 519, 544, 545 Waalkens-Berendsen, D H ...... 2335 ...... 1051*, 1554 Weston, A ...... 55 Wise, S S ...... 519, 544, 545 Waalkes, M ...... 426 Waring, J ...... 1546, 2222 Weston, D D ...... 1802 Wisloff, T F ...... 878 Waalkes, M P ...... 4, 58, 429, 430, Waring, J F ...... 756*, 1708*, 1711, Weston, J ...... 1246 Withuhn, B ...... 1941 ...... 431*, 1663, 2022, 2026, ...... 1819, 1905, 1907 Westwood, F ...... 1386 Witkin, J M ...... 2416 ...... 2027, 2037, 2040, 2055 Warmerdam, J ...... 1632* Weyer, S ...... 293 Witorsch, R J ...... 1950* Waanders, M ...... 48 Warnke, L A ...... 421 Whalan, J E ...... 983, 2311* Witt, K ...... 546 Wachtman, L ...... 2151 Warren, M ...... 1071* Whalley, C ...... 80 Witten, M L ...... 1722 Wada, Y ...... 107* Warren, S ...... 904* Whalley, C E ...... 68* Wittenburg, A ...... 1296, 1298 Wade, M J ...... 881 Washburn, L L ...... 984 Whelan, H T ...... 920, 1085, 1113 Witzmann, F ...... 29*, 824* Wade, T ...... 407 Washer, G ...... 1293 White, C ...... 992*, 2006 Wlodarczyk, B ...... 358 Waechter, F ...... 1231 Washington, N ...... 1924 White, C A ...... 1803 Wogan, G N ...... 530 Waechter, J M ...... 556, 1242, 1524 Wasilak, B A ...... 1328, 1332* White, C C ...... 507 Wohlers, D ...... 2294 Waechter, Jr., J M ...... 1247* Wassenberg, D ...... 1876 White, C W ...... 632 Wohlers, D W ...... 2306* Wagner, A J ...... 1723* Watanabe, G ...... 1652 White, G ...... 1984 Wojcinski, Z ...... 334 Wagner, E D ...... 2299 Watanabe, K ...... 206 White, J R ...... 1274 Wolansky, M J ...... 1203* Wagner, J ...... 1476, 1852 Watanabe, T ...... 107, 602 White, K ...... 1476, 2240* Wolf, A ...... 614*, 1716, 2141 Wagner, J G ...... 1066, 2213* Watanabe, T A ...... 455* White, K L ...... 267, 268*, 274, 2266 Wolf, C J ...... 369, 370* Wagner, V O ...... 555 Waterfield, C ...... 1222 White, L ...... 149, 335, 833 Wolf, D ...... 1229, 2094 Wahl, D ...... 788 Waterson, L ...... 1592* White, L A ...... 151, 832 Wolf, D C ...... 1146, 1206 Waidyanatha, S ...... 2358 Waterson, L A ...... 1937 White, L D ...... 900 Wolf, K K ...... 1004* Waites, C R ...... 982, 2095 Watkins, J A ...... 1481 White, P A ...... 1961 Wolf, P ...... 473 Waits, E ...... 152* Watkins, J B ...... 920 White, P D ...... 2311 Wolfe, G ...... 1245, 2091 Wakabayashi, N ...... 1348 Watkins, S M ...... 2227, 2231* White, R ...... 982 Wolfe, G W ...... 2101 Wakasugi, T ...... 204 Watkinson, W P ...... 1698, 2173 White, S S ...... 399* Wolfe, K J ...... 701, 797 Walch, S G ...... 675 Watson, P ...... 617, 2222 White, Jr., K ...... 1750 Wolff, H ...... 372 Waldeck, D H ...... 2003 Watterson, T L ...... 237* Whitehead, R D ...... 1237 Wolff, J A ...... 201 Walker, C ...... 1860, 1863* Watts, G S ...... 424, 427 Whitehead, T ...... 599 Wolff, R ...... 1037 Walker, C C ...... 1568 Watts, J ...... 1568 Whitney, K ...... 1546 Wolfinger, R ...... 1353 Walker, C R ...... 1067 Watts, S ...... 1745 Whittaker, M H ...... 1606, 1607* Wolfinger, R D ...... 1920, 2093 Walker, D ...... 2161 Waugh, L ...... 466 Wible, B ...... 666* Wolford, S ...... 1675 Walker, D M ...... 127, 438, 971 Way, R ...... 80 Wichers, L B ...... 1698*, 2173 Wolterbeek, A ...... 930* Walker, H ...... 2000 Way, W ...... 2357* Wickliffe, J K ...... 701, 2355 Wolterbeek, A P ...... 2335 Walker, H L ...... 2203 Waysek, E ...... 1417 Widholm, J J ...... 1453 Wong, A W ...... 1435* Walker, M K ...... 355, 779*, 2170, 2171 Weaver, C ...... 860 Wihlen, B ...... 360*, 361 Wong, B A ...... 2119 Walker, N ...... 1750, 2164 Weaver, E V ...... 2330 Wijeyesakere, S ...... 1463* Wong, D F ...... 1846 Walker, N J ...... 829, 1537*, 1538 Weaver, J ...... 125 Wijeyesakere, S J ...... 1462 Wong, H ...... 2147 Walker, V ...... 2161 Weaver, J L ...... 295, 296, 1665 Wijsman, J A ...... 1746* Wong, H L ...... 2011* Walker, V E ...... 127, 438, 971, 1182 Webb, M ...... 1585 Wilberding, J ...... 1496 Wong, P ...... 777 Wall, H ...... 2331* Webb, T R ...... 243, 1050, 1051 Wilbur, S ...... 2306 Wong, P S ...... 950* Wall, K ...... 1984 Webber, M M ...... 429, 430, Wilfong, E R ...... 1056, 1241 Wong, S S ...... 1722 Wallace, A D ...... 1328, 1332 ...... 2027, 2037 Wilke, A V ...... 289 Wong -Riley, M T ...... 1085 Wallace, D ...... 1238 Webber, S ...... 2249 Wilkins, s ...... 1592 Wong-Riley, M ...... 1113 Wallace, K B ...... 484, 1083, Weber, D N ...... 1119 Will, Y ...... 1808, 1908, 1909 Wong-Yim, P ...... 881* ...... 2155, 2158, 2342 Weber, T ...... 2349* Willard, K ...... 1528 Woo, E ...... 1389, 1393* Wallenborn, J ...... 1062, 2173 Weeks, J A ...... 1570 Willett, C ...... 39*, 1535 Woo, G ...... 57 Wallenborn, J G ...... 1063, 1194* Weems, J M ...... 1881* Willett, K ...... 711, 713* Woo, J ...... 624 Waller, D P ...... 686 Weghorst, C M ...... 1648* Willett, K L ...... 63, 1246, 1879 Wood, B ...... 2176 up-to-date information at www.toxicology.org 277 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Author Index (Continued) Wood, B F ...... 1021 Yang, R ...... 2123, 2126 Z Zimmermann, C ...... 1675 Wood, C ...... 902*, 1168 Yang, R S ...... 1278 Zaar, A ...... 788 Zimmermann, J L ...... 290 Wood, C R ...... 932 Yang, S ...... 1407*, 2064 Zacharewski, T ...... 214, 315*, Zinkovsky, D ...... 1979 Wood, S G ...... 587, 1004 Yang, T ...... 655, 659 ...... 782, 985, Zirl, R ...... 1691 Wood, W H ...... 2418 Yang, W ...... 687 ...... 990, 996, 1336 Zitoun, P ...... 1532 Woodall, G M ...... 1635 Yang, Y ...... 505, 756, Zacharewski, T R ...... 82, 221, Zmuta, J ...... 1610 Woods, C ...... 1126 ...... 1907, 2007, 2008 ...... 227, 398, Zokowski, K ...... 608 Woods, C G ...... 194* Yang, Z ...... 408 ...... 403, 1337, 1340 Zong, Q ...... 2343 Woods, L ...... 1448 Yantasee, W ...... 189*, 1520 Zacur, H ...... 867 Zoran, M ...... 1761 Woodstock, A D ...... 583*, 585, 591 Yashima, Y ...... 868 Zafar, K S ...... 1099* Zorbas, M ...... 2249 AUTHOR INDEX AUTHOR Woolhiser, M R ...... 769, 774* Yashiro, C ...... 275 Zaffuto, K ...... 265 Zou, X ...... 126 Wormser, U ...... 1910* Yauk, C ...... 181 Zahalka, E ...... 1618*, 1619 Zou, Y ...... 1335* Wortelboer, H ...... 930 Yauk, C L ...... 1961 Zakharyan, R A ...... 111 Zoubek, G ...... 1252 Wray-Cahen, D ...... 2339 Yavanhxay, S ...... 1932 Zamora, G ...... 1824 Zuehlke, U ...... 1311, 1318* Wright, J ...... 953, 1222, 1231 Yawata, A ...... 702 Zanardi, T A ...... 292, 625* Zuena, A ...... 1454 Wright, L K ...... 1461* Ye, K ...... 367 Zang, J ...... 1673 Zuo, P ...... 2055* Wright, P ...... 716* Ye, Y ...... 2020 Zang, Y ...... 792* Zuscik, M J ...... 365, 1376* Wright, P F ...... 1736* Yea, S ...... 1719* Zank, S A ...... 2410 Wrighton, S A ...... 1004 Yeager, M ...... 526 Zapata-Perez, O ...... 1814 Wrightson, M ...... 902 Yeager, R L ...... 920* Zarbl, H ...... 1647 Wu, B ...... 615 Yeatts, J L ...... 842 Zaroogian, G E ...... 1566 Wu, D ...... 612 Yee, S B ...... 1010* Zavecz, J H ...... 310 Wu, E ...... 2016 Yee, S F ...... 531, 557, 1721* Zawia, N H ...... 335*, 340* Wu, F ...... 948* Yeh, J Z ...... 1490 Zeevalk, G D ...... 1484 Wu, H ...... 189, 583, 692* Yellowhair, M ...... 2078 Zehr, R D ...... 932 Wu, J ...... 1307 Yilmazer, M ...... 697 Zeidler-Erdely, P C ...... 1059* Wu, K ...... 408 Yin, S ...... 526 Zeigler, P ...... 1601, 1966 Wu, M ...... 2065 Yin, X ...... 265, 345* Zeise, L ...... 113, 122, Wu, R ...... 1185 Yin, Z ...... 1775 ...... 726*, 899*, 910 Wu, W ...... 639, 640, 1513 Yip, S S ...... 1832 Zelikoff, J T ...... 260, 276*, 928 Wyde, M E ...... 1537, 1538* Yohe, H ...... 1004 Zeller, A ...... 518* Yokley, K ...... 2372* Zemlin, R ...... 1088* Yokoi, T ...... 204* Zen, J ...... 1999 X Yokokawa, S ...... 2140 Zeng, Y ...... 2118 Xi, G ...... 1103 Yolanda, A ...... 1401 Zermeno-Gonzalez, E ...... 112 Xia, X ...... 843 Yonamine, H ...... 2154 Zerouala, A ...... 1301 Xia, X R ...... 823*, 842 Yonemoto, J ...... 1539 ZeRuth, G ...... 776* Xia, Y ...... 215, 407, 408, 1015 Yoneyama, A ...... 1309 Zervos, P ...... 2000 Xia, Z ...... 1109* Yoo, L ...... 786 Zhang, D ...... 2007 Xiao, J ...... 2002 Yoon, B ...... 577 Zhang, F ...... 1329* Xiao, W ...... 1790 Yoon, D ...... 964 Zhang, H ...... 161, 1360 Xiao, X ...... 991 Yoon, J ...... 2349 Zhang, J ...... 125, 295*, Xie, A ...... 2164 Yoon, K ...... 1362 ...... 296, 1665, Xie, H ...... 544* Yoon, L ...... 1089 ...... 1858, 2046, 2130 Xie, J ...... 1767 Yoon, M ...... 635* Zhang, L ..210*, 526, 981*, 1757, 1997 Xie, L ...... 346, 1660* Yoon, T ...... 1049 Zhang, N ...... 1755* Xie, R ...... 1381* Yoon, Y ...... 1339, 1359 Zhang, Q ...... 2116*, 2118 Xie, W ...... 17, 19*, 1322, 1330 York, M ...... 2153 Zhang, R ...... 228 Xie, Y ...... 957, 1330* York, R ...... 253 Zhang, W ...... 470, 2026 Xiong, K M ...... 2172 Yoshida, M ...... 925, 1652*, Zhang, X ...... 1219*, 1249, 1370, Xochitl S, R ...... 1401 ...... 2100*, 2280 ...... 1647*, 1833, 2005 Xu, F ...... 460 Yoshida, Y ...... 2281 Zhang, Y ...... 1307 Xu, J ...... 754*, 1888, 1956 Yoshiharu, M ...... 140 Zhang, Z ...... 548 Xu, P ...... 210 Yoshimoto, D ...... 636 Zhao, B ...... 302, 353*, 1543 Xu, Y ...... 362, 547*, 919*, 2123 Yoshimura, H ...... 230* Zhao, H ...... 294 Xue, M M ...... 797 Yoshino, K ...... 230 Zhao, J ...... 865, 890, 1020*, 1277 Yoshioka, M ...... 1086* Zhao, M ...... 1541 Yoshioka, N ...... 877* Zhao, Q ...... 2002, 2003, 2005 Y Yoshizawa, K ...... 1831 Zhao, Q J ...... 2297* Yost, G S ...... 242, 1164, Zhao, S ...... 799, 800 Yabe, K ...... 458 ...... 1385, 1881 Yager, J ...... 2182 Zhao, W ...... 191 Yost, L ...... 2180* Zhao, X ...... 981, 1490* Yager, J W ...... 2195 Yost, L J ...... 2199 Yagi, T ...... 790 Zhao, Y ...... 641*, 1365, 2028 You, A ...... 2334* Zheng, D ...... 1087, 1998 Yagminas, A ...... 181 You, L ...... 1167, 1172*, Yamada, H ...... 163, 1906 Zheng, J ...... 704, 1884, 2362 ...... 1329, 1827 Zheng, K ...... 2263* Yamada, T ...... 1309, 1316, 2280 You, Q ...... 1124 Yamaguchi, T ...... 193, 676, 693*, Zheng, L ...... 181* Young, K M ...... 2144 Zheng, Q ...... 263, 325, 1899 ...... 798, 868, 2269 Young, S ...... 550, 1042*, 1059 Yamamori, I ...... 204 Zheng, W ...... 4*, 190, 191, Youngren, S H ...... 383 ...... 1096, 1754, 1767, Yamamoto, M ...... 978 Younis, H ...... 631 Yamamoto, M L ...... 528, 549* ...... 1771, 1773, 1847* Younis, H S ...... 627*, 1314 Zheng, X H ...... 424, 427 Yamamoto, T ...... 163*, 2442 Yourick, J J ...... 810* Yamamoto, Y ...... 1224 Zheng, Y ...... 339 Yu, H ...... 436 Zhitkovich, A ...... 524*, 532 Yamauchi, H ...... 58 Yu, I ...... 2064* Yamazaki, K ...... 1952, 2110* Zhong, M ...... 1196, 1197 Yu, I J ...... 1752 Zhou, G .. 181, 525, 1250, 1251, 2156* Yamazaki, M ...... 1949 Yu, K ...... 170, 1049, 2053* Yamoto, T ...... 206 Zhou, M ...... 1757 Yu, M ...... 1110 Zhou, X ...... 1558, 1783, 1833, Yan, C ...... 2159 Yu, S ...... 1390* Yan, X ...... 1597*, 2347 ...... 2033, 2039, 2042* Yu, W W ...... 829 Zhou, Y ...... 994, 1846, 1906* Yanagisawa, Y ...... 1952*, 2110 Yu, X ...... 445, 898*, 1784 Yang, A ...... 1669* Zhu, C ...... 1815 Yuan, W ...... 704, 1884, 2362* Zhu, H ...... 1020 Yang, C ...... 905, 2115 Yuan, Y ...... 1658, 1777*, 1779 Yang, C S ...... 65 Zhu, J ...... 662 Yue, P ...... 988 Zhu, Y ...... 891 Yang, D ...... 1441, 1450* Yueh, M ...... 778 Yang, H ...... 2159 Ziegler, G ...... 598 Yum, Y ...... 450*, 1794 Ziegler, P ...... 2293 Yang, I ...... 952 Yunomae, K ...... 667* Yang, J ...... 64*, 826, 827, 987, Zielinska, B ...... 860, 2212 Yuschak, M M ...... 618 Ziemba, S E ...... 1176 ...... 1389, 1605*, 2420* Yusoff, K ...... 1165 Yang, L ...... 190*, 1353 Zimmerman, K ...... 1801 Yang, M ...... 367, 1413* Zimmerman, L J ...... 509 278 SOT's 45th Annual Meeting 45th Annual Meeting and ToxExpo
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up-to-date information at www.toxicology.org 279 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2005–2006 Council Kendall B. Wallace James A. Popp George B. Corcoran
President Vice President Vice President-elect
• Finance Committee, • Board of Publications, • IUTOX Councilor Member Auditor • Nominating Committee, • IUTOX Councilor • Endowment Liaison • Student Advisory Implementation Task • Post-Doctoral Assembly, Committee, Liaison Force, Co-Liaison Liaison • Finance Committee, • Program Committee, Member Vice Chairperson
LEADERSHIP • Program Committee, Chairperson, Liaison
Norbert E. Kaminski Gary P. Carlson Janice E. Chambers
Treasurer Secretary Secretary-elect • Endowment • Communiqué, Editor • Council Subcommittee Implementation Task for Non-SOT and • Council Subcommittee for Force, Co-Liaison Contemporary Concepts Regional Chapter Funding, in Toxicology (CCT) • Exhibits Committee, Member Meetings, Member Liaison • Communications Strategy • Council Subcommittee for • Finance Committee, Committee, Co-Liaison Regional Chapter Funding, Chairperson, Liaison • Historian, Liaison Chairperson, Liaison • NIH Funding Task Force, • Regulatory Affairs and • Regional Chapters, Liaison Liaison Legislative Assistance • Scientific Strategy • SOT Affiliates, Liaison Committee, Liaison Committee, Co-Liaison • 45th Anniversary Task Force, Chairperson, Liaison
280 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo 2005–2006 Council (Continued) Linda S. Birnbaum Yvonne P. Dragan Elaine M. Faustman
Past President Councilor Councilor
• Awards Committee, • Continuing Education • Career Resource and Liaison Committee, Liaison Development Committee, Liaison • Board of Publications, • Council Subcommittee for Member, Liaison Regional Chapter Funding, • Council Subcommittee for • Communications Strategy Member Non-SOT and Committee, Co-Liaison Contemporary Concepts • Education Committee, in Toxicology (CCT) • IUTOX Councilor, Liaison Meetings, Chairperson, Member, Liaison • Scientific Strategy Liaison Committee, Co-Liaison • Membership Committee, Liaison LEADERSHIP
Bruce A. Fowler Michael P. Holsapple Shawn Douglas Lamb
Councilor Councilor Executive Director
• Animals in Research (AiR) • Communications Strategy • Communications Strategy Committee, Liaison Committee, Co-Liaison Committee, Staff Liaison • Committee on Diversity • Committee on K–12 • Board of Publications, Initiatives, Liaison Education, Liaison Staff Liaison • Scientific Strategy • Council Subcommittee for • Finance Committee, Committee, Co-Liaison Non-SOT and Contemporary Staff Liaison Concepts in Toxicology • World Wide Web Advisory (CCT) Meetings, Member • IUTOX Councilors, Committee, Liaison Staff Liaison • Mixtures Task Force, Liaison • Mixtures Task Force, • Special Interest Groups Staff Liaison Task Force, Liaison • Nominating Committee, • Specialty Sections, Liaison Staff Liaison up-to-date information at www.toxicology.org 281 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Officers and Councilors
Kendall B. Wallace Gary P. Carlson Elaine M. Faustman President (2005–2006) Secretary (2004–2006) Councilor (2004–2006) T: (218) 726–8899 T: (765) 494–1412 T: (206) 685–2269 F: (218) 726–8014 F: (765) 494–1414 F: (206) 685–4696 [email protected] [email protected] [email protected] James A. Popp Janice E. Chambers Bruce A. Fowler Vice President (2005–2006) Secretary-elect (2005–2006) Councilor (2005–2007) T: (717) 735–3646 T: (662) 325–1255 T: (770) 488–7250 F: (717) 293–4470 F: (662) 325–1031 F: (770) 488–4178 [email protected] [email protected] [email protected] George B. Corcoran Linda S. Birnbaum Michael P. Holsapple Vice President–elect (2005–2006) Past President (2005–2006) Councilor (2005–2007) T: (313) 577–1737 T: (919) 541–2655 T: (202) 659–3306 F: (313) 577–2033 F: (919) 541–4284 F: (202) 659–3617 [email protected] [email protected] [email protected] Norbert E. Kaminski Yvonne P. Dragan Treasurer (2005–2007) Councilor (2004–2006) T: (517) 353–3786 T: (870) 543–7689 F: (517) 432–3218 F: (870) 543–7576 [email protected] [email protected] LEADERSHIP Past Presidents 1961–1962 Harold C. Hodge* 1976–1977 Robert A. Scala 1991–1992 Donald J. Reed
1962–1963 C. Boyd Shaffer 1977–1978 Harold M. Peck 1992–1993 John L. Emmerson
1963–1964 Paul S. Larson* 1978–1979 Leon Golberg* 1993–1994 I. Glenn Sipes
1964–1965 Harry W. Hays* 1979–1980 Tom S. Miya 1994–1995 Meryl H. Karol
1965–1966 Frederick Coulston* 1980–1981 Perry J. Gehring* 1995–1996 Jack H. Dean
1966–1967 Verald K. Rowe* 1981–1982 Robert B. Forney* 1996–1997 James S. Bus
1967–1968 John A. Zapp, Jr.* 1982–1983 Robert L. Dixon* 1997–1998 R. Michael McClain
1968–1969 Carrol S. Weil* 1983–1984 Gabriel L. Plaa 1998–1999 Steven D. Cohen
1969–1970 Ted A. Loomis 1984–1985 Frederick W. Oehme 1999–2000 Jay I. Goodman
1970–1971 Robert L. 1985–1986 Emil A. Pfitzer 2000–2001 Daniel Acosta, Jr. Roudabush* 1986–1987 John Doull 2001–2002 David L. Eaton 1971–1972 Wayland J. Hayes, 1987–1988 Jerry B. Hook 2002–2003 William F. Greenlee Jr.* 1988–1989 James E. Gibson 2003–2004 Marion F. Ehrich 1972–1973 Victor A. Drill* 1989–1990 Roger O. McClellan 2004–2005 Linda S. Birnbaum 1973–1974 Joseph F. Borzelleca 1990–1991 Curtis D. Klaassen 1974–1975 Sheldon D. Murphy*
1975–1976 Seymour L. Friess *Deceased
282 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Elected Committees Awards Membership (Linda S. Birnbaum*) (Elaine M. Faustman*) Deborah A. Cory-Slechta, Chairperson (2005–2006), William Slikker, Jr., Chairperson (2005–2006), Member (2004–2006) Member (2003–2006) Kim Boekelheide (2004–2006) Jeanine L. Bussiere (2004–2007) Patricia E. Ganey (2005–2007) Michael L. Cunningham (2005–2008) Annie M. Jarabek (2004–2006) David C. Dorman (2005–2008) Martin A. Philbert (2005–2007) Jack R. Harkema (2004–2007) (Clarissa Russell Wilson**) Alvaro Puga (2003–2006) TBE, Student Representative, Education ad hoc (2005–2006) (Yvonne P. Dragan*) (Marcia Lawson**) Rosita R. Proteau, Chairperson (2005–2006), Member (2003–2006) Nominating Susan J. Borghoff (2005–2008) (George B. Corcoran*) Lawrence R. Curtis (2005–2008) Marion F. Ehrich, Chairperson (2005–2006) Michelle J. Hooth (2004–2007) Matthew Bogdanffy (2004–2006) B. Paige Lawrence (2004–2007) David L. Eaton (2005–2006) Mark J. Reasor (2003–2006) Marc W. Fariss (2005–2007) Tracy Pickering, Student Representative, ad hoc (2005– Peter L. Goering (2004–2006) 2006) Bruce McCullough (2005–2007) (Betty Eidemiller**) Harold Zenick (2005–2006) (Shawn D. Lamb**)
Appointed Committees LEADERSHIP
Animals in Research (AiR) Career Resource and Development (Bruce A. Fowler*) Committee (CRAD) Jan Oberdoerster, Chairperson (2005–2006), (Elaine M. Faustman*) Member (2004–2007) Yolanda Banks Anderson, Chairperson (2005–2006), Charles Barton (2005–2006) Member (2003–2006) Tracie Bunton (2005–2008) Michel Charbonneau (2003–2006) Nikolay M. Filipov (2005–2008) Barbara Hales (2005–2007) Brian R. Marable (2003–2006) Thomas T. Kawabata (2005–2008) Rebecca Rice (2003–2006) Julia S. Kimbell (2003–2006) Harihara M. Mehendale (2004–2007) Timothy D. Landry (2005–2008) (Betty Eidemiller**) Claude McGowan (2005–2008) Willie J. McKinney (2004–2007) Board of Publications Virginia C. Moser (2004–2007) Linda S. Birnbaum*, Member (2004–2006) Stephanie Smith-Roe, Student Representative, Brian J. Day, Chairperson (2005–2006), Member ad hoc (2005–2006) (2002–2006) (Marcia Lawson**) A. Jay Gandolfi (2005–2009) William R. Kelce (2004–2008) Lois D. Lehman-McKeeman, ToxSci Editor, Auditor Nancy Ann Monteiro-Riviere (2003–2007) James A. Popp, Auditor (2004–2007) (Shawn D. Lamb**)
* Council Liaison ** Staff Liaison up-to-date information at www.toxicology.org 283 TBE=To Be Elected 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Appointed Committees (Continued)
Committee on Diversity Initiatives Continuing Education (Bruce A. Fowler*) (Yvonne P. Dragan*) Peter T. Thomas, Chairperson (2005–2006), Jennifer Orme Zavaleta, Chairperson (2005–2006), Member (2003–2006) Member (2003–2006) Vicente Santa Cruz, Co-Chairperson (2005–2006), Leigh Ann Burns-Naas (2005–2007) Member (2005–2008) Laurie Couture Haws (2004–2007) Javier Avalos (2005–2007) James Kang (2005–2008) Kim Daniel (2005–2008) Douglas Alan Keller (2003–2006) Marquea D. King (2003–2006) Thomas A. Lewandowski (2005–2008) Heather E. Kleiner (2005–2007) Christiane Massicotte (2005–2008) Charles Miller, III (2005–2008) Jeffrey Maurice Peters (2003–2006) Alice R. Villalobos (2005–2006) Douglas C. Wolf (2004–2007) Myrtle A. Davis, ad hoc Mashael Al-Namaeh, Student Representative, Jose Manautou, ad hoc ad hoc (2005–2006) Dennis Nass, ad hoc (Nichelle Sankey**) Michelle J. Hooth, Education Liaison (2005–2006) Carey Hines, Student Representative, ad hoc (2005–2006) Endowment Implementation Task Force (Betty Eidemiller**) (Norbert E. Kaminski* and James A. Popp*) I. Glenn Sipes, Chairperson (2005–2006) LEADERSHIP Committee on K–12 Education James E. Klaunig (2005–2006) (Michael P. Holsapple*) Roger O. McClellan (2005–2006) Kenneth E. McMartin, Chairperson (2005–2006), Rick G. Schnellmann (2005–2006) Member (2003–2006) Jacqueline H. Smith (2005–2006) Kathleen K. Dougherty (2005–2007) (Clarissa Russell Wilson**) Vanessa Fitsanakis (2005–2007) Suzanne Fitzpatrick (2004–2007) Finance Steven G. Gilbert (2005–2008) Norbert E. Kaminski*, Chairperson (2005–2006), Pamela Shubat (2005–2008) Member (2004–2006) Nicole Venice Soucy (2005–2008) William J. Brock (2004–2007) Stacie Wild (2005–2007) Erik Dybing (2003–2006) B. Paige Lawrence, Education Liaison (2005–2006) James A. Popp (2005–2007) Joseph Lynch, Student Representative, Jacqueline H. Smith (2005–2008) ad hoc (2005–2006) Kendall B. Wallace (2004–2006) (Betty Eidemiller**) (Shawn D. Lamb**)
Communications Strategy Committee Historian (Linda S. Birnbaum*, Gary P. Carlson*, and (Gary P. Carlson*) Michael P. Holsapple*) Ernest Hodgson, Chairperson (2004–2006) Bernard D. Goldstein, Chairperson (2005–2007), (Rita Rose**) Member (2005–2007) Matthew S. Bogdanffy (2005–2007) IUTOX Councilors Ann de Peyster (2005–2007) Linda S. Birnbaum*, Member (2004–2007) Annie M. Jarabek (2005–2007) Daniel Acosta, Jr., Chairperson (2005–2006), James C. Lamb (2005–2007) Member (2004–2007) (Shawn Lamb**) George B. Corcoran (2004–2007) Marion F. Ehrich (2004–2007) Kendall B. Wallace (2004–2007) (Shawn D. Lamb**)
* Council Liaison ** Staff Liaison 284 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Appointed Committees (Continued)
Mixtures Task Force Program (Michael P. Holsapple*) James A. Popp*, Chairperson (2005–2006), Member Moiz Mumtaz, Chairperson (2005–2006) (2004–2006) Chris Borgert (2005–2006) George B. Corcoran, Vice Chairperson (2005–2006), John Bucher (2005–2006) Member (2005–2007) James Bus (2005–2006) Philip J. Bushnell (2004–2007) Rory Conolly (2005–2006) Lori A. Dostal (2003–2006) William Farland (2005–2006) Michael R. Franklin (2004–2007) Jay Goodman (2005–2006) Dori R. Germolec (2003–2006) John Groten (2005–2006) Ronald J. Gerson (2005–2008) James Klaunig (2005–2006) Bruce J. Kelman (2004–2007) Kanan Krishnan (2005–2006) Kannan Krishnan (2003–2006) Ann Mason (2005–2006) Lynda L. Lanning (2005–2008) Greg Schiefer (2005–2006) John B. Morris (2005–2008) Jane Ellen Simmons (2005–2006) Gary H. Perdew (2003–2006) I. Glenn Sipes (2005–2006) Gary D. Stoner (2005–2008) Claudia Thompson (2005–2006) Martin Vandenberg (2004–2007) (Shawn D. Lamb**) (Nichelle Sankey**)
NIH Funding Task Force Regulatory Affairs and Legislative Assistance (Norbert E. Kaminsky*) Committee David L. Eaton, Chairperson (2004–2006), Member (Gary P. Carlson*) (2004–2006) Peter L. Goering, Chairperson (2004–2006), Member Ronald N. Hines (2004–2006) (2003–2006) Curtis D. Klaassen (2004–2006) Kulbir S. Bakshi (2003–2006)
Serrine S. Lau (2004–2006) Mike Bolger (2004–2007) LEADERSHIP Jose E. Manautou (2004–2006) Lawrence J. Fischer (2005–2008) Alvaro Puga (2004–2006) Larry Johnson (2005–2008) (Betty Eidemiller**) Ruth Ann Rudel (2004–2007) Charles Lindamood, ad hoc Post-Doctoral Assembly John Norman, Student Representative (2005–2006) (George B. Corcoran*) (Marcia Lawson**) James P. Luyendyk, Chairperson (2005–2006) Jennifer M. Duringer, Co-Chairperson (2005–2006) Scientific Strategy Committee Mark W. Powley, Secretary/Treasurer (2005–2006) (Janice E. Chambers*, Yvonne P. Dragan*, and Laine Peyton Myers, Councilor (2005–2006) Bruce A. Fowler*) (Betty Eidemiller**) Cheryl L. Walker, Chairperson (2005–2007), Member (2005–2007) Dennis J. Paustenbach (2005–2007) Lois D. Lehman-McKeeman (2005–2007) Bernard A. Schwetz (2005–2007) Lewis L. Smith (2005–2007) (Clarissa Russell Wilson**)
* Council Liaison up-to-date information at www.toxicology.org 285 ** Staff Liaison 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Appointed Committees (Continued)
Special Interest Groups Task Force World Wide Web Advisory Committee (Michael P. Holsapple*) (Bruce A. Fowler*) Jose Manautou, Chairperson (2005–2006) Michael L. Dourson, Chairperson (2004–2006), James Kang (2005–2006) Member (2003–2006) Jieun Lee (2005–2006) Christopher P. Chengelis (2004–2007) Prakash Nagarkatti (2005–2006) Howard Perry Glauert (2004–2007) Chudy Nduaka (2005–2006) Ruth A. Roberts (2003–2006) Eve Oberdorster (2005–2006) Philip Wexler (2005–2008) Gina Pastino (2005–2006) Tracy M. Williams (2005–2008) Mari Stavanja (2005–2006) Laine Peyton Myers, ad hoc (Rita Rose**) Joseph Lynch, Student Representative, ad hoc (2005–2006) Student Advisory Committee (Deborah O’Keefe**) (Kendall B. Wallace*) Tracy Pickering, Chairperson, Education Committee Council Subcommittee for Non-SOT Funding John Norman, Co-Chairperson (Lake Ontario), RALA and Contemporary Concepts in Toxicology Jessica Berthiaume, Secretary (Northland) Meetings Mashael Al-Namaeh (National Capital Area), CE Elaine M. Faustman*, Chairperson (2004–2006), Committee Member (2003–2006)
LEADERSHIP Vishakha Bhave (South Central) Janice Chambers (2005–2006) Cary Coburn (Southern California) Michael Holsapple (2005–2006) Kristina DeSmet (Midwest) (Rita Rose**) Courtney Hill (Gulf Coast) Carey Hines (Southeastern), CDI Council Subcommittee for Regional Jessica Houghton (Northern California) Chapter Funding Yu Jiang (Central States) Janice Chambers*, Chairperson (2005–2006) Natalie Lassen (Mountain West) Gary P. Carlson (2003–2006) Joseph P. Lynch (Northeast), Committee on K–12 Yvonne Dragan (2005–2006) Education, WWWAC (Rita Rose**) Samuel C. McNeely (Ohio Valley) Ashley R. Murray (Allegheny-Erie), Specialty Sections 45th Anniversary Task Force Liaison Gary P. Carlson*, Chairperson (2005–2006) Patrick Shaw (Michigan) Ann de Peyster (2005–2006) Stephanie Smith-Roe (Pacific Northwest), Ernie Hodgson (2005–2006) CRAD Committee (Rita Rose**) Lauren Tarantino (Mid-Atlantic) Beth Wasilak (North Carolina) (Betty Eidemiller**)
* Council Liaison ** Staff Liaison 286 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo * Membership Totals Officers—Specialty Sections
Biological Modeling (101*) Immunotoxicology (313*) Occupational and Public Alan G. E. Wilson, President Kenneth L. Hastings, President Health (129*) Charles Timchalk, Vice President Mitchell D. Cohen, Vice President Heather Burleigh-Flayer, President Sean M. Hays, Vice President-elect Stephen B. Pruett, Vice President-elect Harold Zenick, Vice President Elaina M. Kenyon, Secretary/Treasurer Robert W. Luebke (Past President), Patricia A. Weideman, Vice President-elect John M. Frazier (Past President), Jeff Gregory S. Ladics, Michael J. McCabe, Marth M. Moore, Secretary/Treasurer M. Gearhart and Lisa M. Sweeney, and Helen V. Ratajczak, Councilors David A. Morgott (Past President), Councilors Jamie DeWitt, Student Representative Arnold J. Schecter and Bryan D. Hardin, Rebecca Ann Clewell, Student Representative Councilors In Vitro (118*) Jianyong Wang, Student Representative Carcinogenesis (238*) Sidney Green, President John E. French, President George L. DeGeorge, Vice President Regulatory and Safety Evaluation Michael Lee Cunningham, Vice President Peter J. Harvison, Secretary/Treasurer (460*) Mark S. Miller, Vice President-elect Julio Cesar Davila (Past President), Ronald S. Slesinski, President Kyle Kolaja, Secretary/Treasurer Mark E. Blazka and Robert T. Dunn, James T. MacGregor, Vice President Ruth A. Roberts (Past President), Abby Jacobs, Councilors Lisa M. Kamendulis, and Brian G. Short, Robert Kuester, Student Representative James D. Green, Vice President-elect Councilors Vijayapal Reddy, Secretary/Treasurer Noel J. Raynal, Student Representative Inhalation (220*) Ronald J. Gerson (Past President), Suzanne C. Fitzpatrick and Andrea B. Weir, MaryJane K. Selgrade, President Councilors Comparative and Veterinary (79*) Michael W. Foster, Vice President Myrtle A. Davis, President Deepak K. Bhalla, Vice President-elect Reproductive and Developmental Wilson Kiiza Rumbeiha, Vice President Jacob D. McDonald, Secretary/Treasurer Daniel K. Ness, Vice President-elect Charles George Plopper (Past President), (278*) Randy D. Jones, Secretary/Treasurer Lung Chi Chen, Jon A. Hotchkiss, Urmila Dana L. Shuey, President William Mark Valentine (Past President), P. Kodavanti, and Michelle V. Fanucchi, Jerrold J. Heindel, Vice President Jay C. Albretsen and Laurene Marie Councilors Rochelle W. Tyl, Vice President-elect Fomby, Councilors George Foley, Secretary/Treasurer Sachin Devi, Student Representative Mechanisms (289*) John M. Rogers (Past President), Rayetta Daniel C. Liebler, President C. Grasty, William R. Kelce, Barry Dermal Toxicology (121*) Kenneth S. Ramos, Vice President S. McIntyre, and Eve Mylchreest, Councilors Robert L. Bronaugh, President Dean P. Jones, Vice President-elect Jennifer Rayner, Student Representative LEADERSHIP James N. McDougal, Vice President Monica A. Valentonic, Secretary/Treasurer David W. Hobson, Vice President-elect Serrine S. Lau (Past President), Qin M. Chen Cynthia A. Ryan, Secretary/Treasurer and Dennis Peterson, Councilors Risk Assessment (444*) Nancy A Monteiro-Riviere (Past President), Adrian Nanez, Student Representative Kannan Krishnan, President Carol S. Auletta and William Gerald Michael L. Gargas, Vice President Reifenrath, Councilors Metals (142*) Jennifer Orme-Zavaleta, Vice President-elect Adrienne Black, Student Representative Donald R. Smith, President Lynne T. Haber, Secretary/Treasurer Michael J. McCabe, Vice President Annie M. Jarabek (Past President), Teresa L. Leavens and Deborah M. Proctor, Drug Discovery Kirk T. Kitchin, Vice President-elect Councilors J. Christopher States, Secretary/Treasurer Toxicology (202*) Mayurranjan Mitra, Student Representative Drew Badger, President Maryka H. Bhattacharyya (Past President), Ronald D. Snyder, Vice President Jie Liu and Toby G. Rossman, Councilors Toxicologic and Exploratory Carl L Alden, Vice President-elect Elena S. Craft, Student Representative John W. Davis, II, Secretary/Treasurer Pathology (109*) Bruce Car and Thomas Jones, Councilors Molecular Biology (148*) Jack R. Harkema, President Melissa A. Runge-Morris, President Linda L. Lanning, Vice President Ethical, Legal, and Social Craig Marcus, Vice President Patrick J. Haley, Vice President-elect Issues (50*) Richard S. Pollenz, Vice President-elect Susan G. Emeigh Hart, Secretary/Treasurer Heidi J. Einolf, Secretary/Treasurer Brian G. Short (Past President), Glenn H. Steven Gilbert, President Jack P. Vanden Heuvel (Past President), Cantor and Gail L. Walter, Councilors Jacques P. J. Maurissen, Vice President Andrew J. Annalora, Michael J. Carvan, Alison Hege, Student Representative Spencer R. Mortensen, Secretary/Treasurer and Thomas R. Sutter, Councilors Bruce Kelman, Thomas McHugh, and Errol Andrew Annalora, Student Representative Women in Toxicology (178*) Zeiger, Councilors Mary Ellen Cosenza, President Darin Sujjavanic, Student Representative Neurotoxicology (268*) Carol S. Auletta, Vice President Richard F. Seegal, President Maryka H. Bhattacharyya, Secretary/Treasurer Food Safety (114*) Robert C. MacPhail, Vice President Eva Oberdorster (Past President), Stacey L. Bryan Delaney, President M. Christopher Newland, Vice President- Wild, Councilor George A. Burdock, Vice President elect Sharmilee Sawant, Student Representative Bruce G. Hammond, Vice President-elect Mary E. Gilbert, Secretary/Treasurer Kenneth A. Voss, Secretary/Treasurer Carey N. Pope (Past President), Stephen M. Ronald T. Riley (Past President), Michael Lasley and Pamela J. Lein, Councilors Bolger, and Craig Llewellyn, Councilors Michele Taylor, Student Representative Donthamsetty Shashkiran, Student Representative up-to-date information at www.toxicology.org 287 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo * Membership Totals Officers—Regional Chapters
Allegheny-Erie (73*) Midwest (165*) Northland (65*) Melanie Sarah Flint, President Kevin D. Williams, President Helen M. Goeden, President Mark Weisberg, Vice President Robin C. Guy, Vice President Thomas P. Brunshidle, President-elect Maureen Gwinn, President-elect Barbara J. Struthers, Secretary Catherine F. Jacobson, Secretary/Treasurer Robin E. Gandley, Secretary Linda L. Tam, Treasurer Elizabeth V. Wattenberg (Past President), William James Mackay, Treasurer Bruce A. Trela (Past President), Stephen C. Gordon, Deanna Luebker, Lawrence M. Milchak (Past President), William M. Bracken, William D. and Pamela Shubat, Councilors Lori Batelli, Aaron Barchowsky, Johnson, Jim Lu, Chuck Mattis, Jessica M. Berthiaume, Student Jim Scabilloni, and Michael C. Savides, and Peter J. Thomford, Councilors Representative Thomas W. Simmons, Councilors Kristina DeSmet, Student Representative Ashley Murray, Student Representative Ohio Valley (209*) Mountain West (123*) Y. James Kang, President Central States (197*) Chris Reilly, President Charles V. Smith, President-elect Charles Barton, President Matthew Campen, Vice President August V. Wilke, Vice President Yu-Jui Yvonne Wan, Vice President Richard R. Vaillancourt, Vice President-elect Timothy P. Dalton, Secretary Lora Arnold, Secretary/Treasurer Nathan J. Cherrington, Secretary/Treasurer David C. Ackley, Treasurer Samuel Cohen (Past President), Linda C. Quattrochi (Past President), Lisa Hollie I. Swanson (Past President), Diane Birt, Greg Reed, K.S. Rao, Ahern, Qi Chen, Natalie Lassen, and Mary Beth Genter and Amy L. Roe, and Suzanne Hendrich, Councilors Ronald B. Tjalkens, Councilors Councilors Yu Jiang, Student Representative Natalie Lassen, Student Representative Samuel C. McNeely, Student Representative Gulf Coast (98*) National Capital Area Chapter Pacific Northwest (139*) Susan Fischer, President (264*) Rosita R. Proteau, President Brian W. Brooks, Vice President Harry A. Milman, President Andrij Holian, Vice President LEADERSHIP Yanan Tian, Vice President-elect Suzanne Compton Fitzpatrick, President- Bruce J. Kelman, Vice President-elect Sharon Petronella, Secretary elect Cecile M. Krejsa, Secretary/Treasurer Mary F. Kanz, Treasurer Pamela L. Chamberlain, Secretary Peter S. Spencer, (Past President), David M. David J. McConkey, (Past President), TBE Jennifer W. Sekowski Treasurer Shepherd and Carin Thomas, Councilors and TBE, Councilors David Jacobson Kram (Past President), Stephanie L. Smith-Roe, Student Courtney Hill, Student Representative Gary J. Burin, Lynn Flowers, Representative and Thomas J. Flynn, Councilors Lake Ontario (24*) Mashael Al-Namaeh, Student Representative South Central (74*) TBE, President Sharon A. Meyer, President TBE, Vice President North Carolina (328*) Martin J. Ronis, Vice President TBE, Treasurer/Secretary Nigel J. Walker, President Tammy R. Dugas, Vice President-elect TBE (Past President), TBE and TBE, Michael P. Waalkes, Vice President Russell L. Carr, Secretary Councilors Virginia C. Moser, Vice President-elect Kristine L. Willett, Treasurer John Norman, Student Representative Elaina M. Kenyon, Secretary/Treasurer Kenneth E. McMartin (Past President), David C. Dorman (Past President), Heather Kleiner and Tucker A. Patterson, Michigan (125*) Kevin M. Crofton and Brenda Faiola, Councilors Jim McKim, President Councilors Vishakha Bhave, Student Representative Brandi Soldo, President-elect Beth A. Wasilak, Student Representative Paul Stemmer, Treasurer/Secretary Southeastern (103*) Stephen W. Frantz (Past President), Northeast (217*) Essam Enan, President Lori Bestervelt, Jeanne Domoradzki Helen V. Ratajczak, President Carol Wood, Secretary/Treasurer and Yvonne Frater, Councilors Joseph V. Rutkowski, Vice President Gary Miller (Past President), Julie Coffield Patrick J. Shaw, Student Representative Douglas J. Ball, Secretary/Treasurer and P. Markus Dey, Councilors Jatinder Singh (Past President), Carey Hines, Student Representative Mid-Atlantic (439*) Brian J. Aneskievich, Gary B. Freeman, Michael F. Kelley, President and Vic Kadambi, Councilors Southern California (189*) Angelique Braen, Vice President Joseph P. Lynch, Student Representative Drew Badger, President John W. Kille, Vice President-elect David Hovland Vice President Janet C. Gould, Secretary/Treasurer Northern California (175*) Randolph Sleet, Vice President-elect David W. Cragin (Past President), Linval DePass, President Anthony Ndifor, Secretary Lauren D’Angelo, George L. DeGeorge, George Alexeeff, President-elect Tina Leakakos, Treasurer Anthony R. Schatz, Lauren M. Taratino Sanjay Chanda, Vice President John Wisler (Past President), Michelle and Margaret A. Wojke, Councilors Stephen DiZio, Secretary Horner and Gregory Stevens, Councilors Lauren Tarantino, Student Representative Carol Green, Treasurer Cary Coburn, Student Representative Susan A. Rice (Past President), Robert Baldwin and George Clemens, Councilors Jessica Houghton, Student Representative
TBE: To Be Elected 288 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards
In recognition of distinguished toxicologists and students, SOT presents several prestigious awards each year. In addition to receiving the award stipend and plaque, recipients are honored at a special Awards Ceremony at the SOT Annual Meeting and their names are listed in SOT publications. The deadline for 2007 award nominations is October 9, 2006.
The Awards Committee reviews applications for SOT Awards and Sponsored Awards for scientists. Nominations for most of these awards must be submitted by a sponsor and a seconder who are full members of SOT using the On-Line Award Nomination Form. The supporting documentation must indicate the candidate's achievements in toxicology and is critical in the review of each application. See the award description for the additional requirements for some of the awards, including the Sponsored Awards. The Best Paper Awards are reviewed by the Board of Publications.
Student awards, both SOT and Sponsored Awards, will be reviewed by the Awards Committee in 2006, and application procedures are specific for each award. Other student awards are available through Regional Chapters and Specialty Sections. A student may apply for any award for which he or she is eligible and may apply for and receive multiple awards, whether SOT, Regional Chapters, or Specialty Sections sponsor the awards. Policies related to travel awards are determined by the sponsor (SOT, Regional Chapter, or Specialty Section).
Full descriptions of each award, application procedures, and names of past recipients may be found on the SOT Web site at www.toxicology.org. Award Descriptions
Indicates an SOT Sponsored Award Achievement Award
The Achievement Award is presented to a member of the 1986 ...... Sam Kacew Society of Toxicology who has less than 15 years experi- 1987 ...... James S. Bus ence since obtaining his/her highest earned degree (in the 1988 ...... Jeanne M. Manson year of the Annual Meeting of the Society of Toxicology) 1989 ...... James P. Kehrer and who has made significant contributions to toxicology. 1990 ...... Michael P. Waalkes This award consists of a plaque and a cash stipend. 1991 ...... Debra Lynn Laskin 1992 ...... Michael P. Holsapple Award Recipients 1993 ...... David L. Eaton 1994 ...... James L. Stevens 1967 ...... Gabriel L. Plaa 1995 ...... Lucio G. Costa 1968 ...... Allan H. Conney 1996 ...... Kenneth Ramos 1969 ...... Samuel S. Epstein 1997 ...... Kevin E. Driscoll 1970 ...... Sheldon D. Murphy 1998 ...... Rick G. Schnellmann 1971 ...... Yves Alarie 1999 ...... Michel Charbonneau REFERENCE 1972 ...... Robert L. Dixon 2000 ...... Christpher Bradfield 1973 ...... (No Award) 2001 ...... Martin Philbert 1974 ...... Morris F. Cranmer 2002 ...... Ruth Roberts 1975 ...... Ian C. Munro 2003 ...... Lois D. Lehman-McKeeman 1976 ...... Curtis D. Klaassen 2004 ...... David C. Dorman 1977 ...... James E. Gibson 2005 ...... (No Award) 1978 ...... Raymond D. Harbison 2006 ...... Jose E. Manautou 1979 ...... Michael R. Boyd 1980 ...... Philip G. Watanabe 1981 ...... (No Award) 1982 ...... Frederick P. Guengerich 1983 ...... (No Award) 1984 ...... Melvin E. Andersen 1985 ...... Alan R. Buckpitt up-to-date information at www.toxicology.org 289 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards (Continued) AstraZeneca Traveling Arnold J. Lehman Award Lectureship Awards The Arnold J. Lehman Award is presented to recognize The AstraZeneca Traveling Lectureship Awards are an individual who has made a major contribution to presented through the Society of Toxicology to recog- risk assessment and/or the regulation of chemical agents, nize excellence in research and service in toxicology. including pharmaceuticals. The contribution may have AstraZeneca, Ltd., provides one or two awards annu- resulted from the application of sound scientific prin- ally to promote greater collaboration between European ciples to regulation and/or from research activities that and North American toxicologists and to enable North have significantly influenced the regulatory process. The American toxicologists to undertake a three-four week nominee may be employed in academia, government, or lecture tour of Europe. The awards are intended to famil- industry and must be a SOT member. This award consists iarize recipients with research and regulatory issues in of a plaque and a cash stipend. Europe as well as bring a North American perspective to these issues. Candidates for these awards should be Award Recipients established, mid-career North American scientists who are 1980 ...... Allan H. Conney members of the Society and who demonstrate the ability 1981 ...... Gabriel L. Plaa to develop collaborative relationships with European 1982 ...... Gary M. Williams colleagues. The awards are given each year in the amount 1983 ...... David P. Rall of $6,000 each. 1984 ...... Tibor Balasz 1985 ...... Frederick Coulston* Award Recipients 1986 ...... Gerrit Johannes Van Esch 1990 ...... Robert I. Krieger, Joseph R. Landolph 1987 ...... John P. Frawley 1991 ...... Sam Kacew 1988 ...... Kundan S. Khera* 1992 ...... Charles V. Smith, Jerold A. Last 1989 ...... Richard H. Adamson 1993 ...... Terrence James Monks, Harihara H. Mehendale 1990 ...... Harold C. Grice 1995 ...... David L. Eaton, Hanspeter R. Witschi 1991 ...... Bernard A. Schwetz 1996 ...... Rick G. Schnellmann, James P. Kehrer 1992 ...... Roger O. McClellan 1997 ...... Lucio G. Costa, Durisala Desaiah 1993 ...... Thomas W. Clarkson 1998 ...... Syed F. Ali, Curtis J. Omiecinski 1994 ...... Bruce Ames 1999 ...... Alvaro Pugo 1995 ...... Emil A. Pfitzer 2000 ...... Kenneth Ramos, Garold Yost 1996 ...... John F. Rosen 2001 ...... Ronald Hines, Richard Seegal REFERENCE 1997 ...... (No Award) 2003 ...... William D. Atchison 1998 ...... Helmut Alfred Greim 2004 ...... Charlene A. McQueen 1999 ...... (No Award) 2005 ...... Kevin Crofton 2000 ...... Carole A. Kimmel and Janardan K. Reddy 2006 ...... Robert A. Roth 2001 ...... Samuel M. Cohen 2002 ...... Dennis Paustenbach 2003 ...... Michael L. Dourson 2004 ...... Melvin E. Andersen 2005 ...... Rory Conolly 2006 ...... Kathryn Mahaffey
290 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards (Continued)
Best Paper in Toxicology and Applied Board of Publications Award Pharmacology The Board of Publications Award for the Best Paper in Award Recipients Toxicological Sciences is presented to the author(s) of the 1995 ...... M. F. Denny, M. F. Ware, W. D. Atchison best paper published in this official SOT publication during 1996 ...... T. A. Slotkin, C. Lau, E. C. McCook, S. E. Lappi, a 12-month period, terminating with the June issue of the ...... F. J. Seidler calendar year preceding the Annual Meeting at which the 1997 ...... P. R. S. Kodavanti, T. R. Ward, J. D. McKinney, award is presented. The author(s) need not be a member of the ...... C. L. Waller, H. A. Tilson Society of Toxicology. Submissions should include a one-page 1998 ...... J. S. Landin, S. D. Cohen, E. A. Khairallah summary of the paper’s contribution to the science of toxi- 1999 ...... S. K. Ramaiah, M G. Soni, T. J. Bucci, cology and a copy of the article for which the nomination ...... H. M. Mehendale, is being made. Any member of the Society may submit one 1999 ...... C. L. Zuch, D. J. O’Mara, D. A. Cory-Slechta title for consideration. In addition, the titles of no more than six 2000 ...... J.E. Staples, N.C. Fiore, D.E. Frazier, Jr., papers to be considered are submitted by the editor of ...... T.A. Gasiewicz, A.E. Silverstone Toxicological Sciences. All papers submitted will be evaluated by 2001 ...... Barbara J. Mounho, Brian D. Thrall the Board of Publications. This award consists of a plaque and a 2002 ...... G.S. Ratra, S.G. Kamita, J.E. Casida cash stipend. (This award was formerly known as the Frank R. 2003 ...... J. Doorn, M. Schall, D. Gage, T. Talley, Blood Award.) ...... C. Thompson, R. Richardson Best Paper in Toxicological Sciences Award Recipients (Frank R. Blood Award) (formerly published as Fundamental and 1974 ...... Yves Alarie Applied Toxicology) 1975 ....Donald J. Ecobichon, G. J. Johnstone, O. Hutzinger 1976 ...... Richard D. Brown 1977 ...... J. Dedinas, George D. DiVincenzo, C. J. Kaplan Award Recipients 1978 ...... Perry J. Gehring, E. O. Madrid, G. R. McGowan, 1995 ...... J. L. Larson, D. C. Wolf, B. E. Butterworth ...... Philip G. Watanabe 1995 ...... M. I. Luster, C. Portier, D. G. Pait, G. J. Rosenthal, 1979 .....R. Fradkin, E. J. Ritter, W. J. Scott, James G. Wilson ...... D. R. Germolec, E. Corsini, B. L. Blaylock, 1980 ...... Jerold A. Last, Peter F. Moore, Otto G. Raabe, ...... P. Pollock, Y. Kouchi, W. Craig, K. L. White, ...... Brian K. Tarkington ...... A. E. Munson, C. E. Comment 1981 ...... Yves Alarie, Martin Brady, 1996 ...... B. C. Allen, R. J. Kavlock, C. A. Kimmel, ...... Christine Dixon, Meryl Karol ...... E. M. Faustman 1982 ...... Melvin E. Andersen, Michael L. Gargas, 1997 ...... F. L. Fort, H. Ando, T. Suzuki, M. Yamamoto, ...... Lawrence J. Jenkins, Jr., Robert A. Jones ...... T. Hamashima, S. Sato, T. Kitazaki, 1983 ...... Henry D. Heck ...... M. C. Matony, G. D. Hodgen 1984 ...... Erik Dybing, Sidney Nelson, Erik Soderlund, 1998 ...... D. D. Parrish, M. J. Schlosser, J. C. Kapeghian, ...... Christer Von Bahr ...... V. M. Traina 1985 ...... Nobumasa Imura, Masae Inokawa, Kyoko Miura 1999 ...... C. A. Franklin, M. J. Inskip, C. L. Baccanale, 1986 ...... Calvin C. Wilhite, M. I. Dawson, K. J. Williams
...... C. M. Edwards, W. I. Manton, E. Edwards, 1987 ...... John Kao, Frances K. Patterson, Jerry Hall REFERENCE ...... E. J. O’Flaherty 1988 ...... Debra L. Laskin, Sungchul Ji, Anne M. Pilaro 2000 ...... H.A Boulares, C. Giardina, C.L. Navarro, 1989 ...... R. G. Cuddihy, W. C. Griffith, ...... E.A. Khairallah, S.D. Cohen ...... Rogene F. Henderson, Joe L. Mauderly, 2001 ...... Jinqiang Chen, Yunbo Li, Jackie A. Lavigne, ...... Roger O. McClellan, M. D. Snipes, Ronald K. Wolff ...... Michael A. Trush, James D. Yager 1990 ...... William P. Beierschmitt, Joseph T. Brady, 2002 ...... M.J. Bajt, J.A. Lawson, S.L. Vonderfecht, ...... John B. Bartolone, D. Stuart Wyand, ...... J.S. Gujral, H. Jaeschke ...... Edward A. Khairallah, Steven D. Cohen 2003 ...... S. Haddad, M. Beliveau, R. Tardif, K. Krishnan 1991 ...... Jay Babcock Silkworth, Daryl Cutler, 2004 ...... Urmila Kodavanti, Carolyn Moyer, ...... Allen Ledbetter, Mette Schlasweiler, Daniel Costa, ...... LuAnn Antrim, Don Houston, Casimir Tumasonis, ...... Russ Hauser, David Christiani, Abraham Nyska ...... Laurence S. Kaminsky 2005 ...... Nicole V. Soucy, Michael A. Ihnat, 1992 ...... Donald A. Fox, Steve D. Rubinstein, Pauline Hsu ...... Chandrashekhar D. Kamat, Linda Hess, 1993 ...... Thomas Mably, Robert W. Moore, Robert W. Goy, ...... Mark J. Post, Linda R. Klei, ...... Richard E. Peterson ...... Callie Clark, Aaron Barchowsky 1994 ...... Susan J. Borghoff, William H. Lagarde 2006 ...... Hiroshi Sawada, Kenji Takami, Satoru Ashai up-to-date information at www.toxicology.org 291 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards (Continued) Colgate-Palmolive Grants for Award Recipients Alternative Research 1988 ...... Ernest Bloom 1989 ...... Gin Hsieh The Colgate-Palmolive Grants for Alternative Research will 1990 ...... Dennis E. Chapman identify and support efforts that promote, develop, refine, or 1991 ...... Anne Walsh validate scientifically acceptable animal alternative methods 1992 ...... Qin Chen to facilitate the safety assessment of new chemicals and 1993 ...... Erika Cretton formulations. Scientists at any stage of career progression 1994 ...... William Chan may submit a proposal. 1995 ...... Bob Van de Water 1997 ...... Alan Parrish High priority will be given to projects that use in vitro or 1999 ...... Russell Thomas non-animal models, reproductive and developmental 2001 ...... Kevin Kerzee, Christopher Reilly toxicology, neurotoxicology, systemic toxicology, sensiti- 2002 ...... Kevin Kerzee zation, and acute toxicity. 2003 ...... Kimberly Miller 2004 ...... Kimberly Miller Applications can be for a single year or multi-year, and 2005 ...... Francis Tukov candidates can reapply for additional funding each year. The maximum award in any one year will not be greater than $40,000. Awards are made as a single lump Colgate-Palmolive/SOT Awards payment. An expert panel from the SOT In Vitro Specialty Section will recommend a prioritized list of applicants for Student Research Training in for funding, with the final awards designated by the SOT Alternative Methods Awards Committee. The purpose of the Colgate-Palmolive/SOT Awards for Student Research Training in Alternative Methods is to en- Award Recipients hance student research training using in vitro methods or 2006 ...... Rola Barhoumi, Abby Benninghoff, alternative techniques to reduce, replace or refine use of ...... Jodie Flaws, Courtney Sulentic, animals in toxicological research. The Education Committee ...... Xiaouzhong Yu will present the awards to graduate students or to institu- tions that provide research internships. Up to five awards, at $3,500 each, are available. Deadlines for applications are Colgate-Palmolive Post-Doctoral February 15, June 15, and October 9. Fellowship Award in In Vitro Graduate Students: The award is for expenses for training REFERENCE Toxicology consistent with the goal of this award program. The training may include, but is not limited to, use of in vitro and ex vivo The Colgate-Palmolive Company sponsors the Colgate- procedures, non-mammalian animal models, computer model- Palmolive Post-Doctoral Fellowship Award in In Vitro ing, and structure-activity relationships. Graduate students may Toxicology through the Society of Toxicology to advance propose to develop expertise in such methodologies at 1) a labo- the development of alternatives to animal testing in ratory away from their home institution; 2) a laboratory at their toxicological research. The award is given in alternate home institution that would not be available to them otherwise; years and includes stipend and research-related costs (up or 3) approved workshops, symposia or continuing education to $38,500) for one year. The award may be extended programs where hands-on training will be received. The training for an additional year upon agreement between Colgate- should help toxicology graduate students enhance their thesis or Palmolive and the post-doctoral fellow. The award is dissertation research. The overall goal is to support the replace- available to post-doctoral trainees employed by academic ment, reduction, or refinement of currently used animal models institutions, federal/national laboratories or research insti- in toxicology research and testing. Awards of up to $3,500 per tutes worldwide. Preference will be given to applicants in student will defray travel, per diem, and training expenses. their first year of post-doctoral study. Applications are due in even calendar years and the fellowship is awarded for Institutions: Awards will also be made to institutions the following year. The next application deadline: October that propose a 10-week research experience for students 9, 2006. (at any level) involving in vitro toxicology or alternative methods to reduce, replace, or refine, the use of animals in toxicology research. 292 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards Award Recipients 1997 ...... Indiana University School of Medicine Visiting Professor: ...... A. Jay Gandolfi 2000 ...... Jason Gross 1997 ...... University of Arizona Health Science Center 2001 ...... Jason Biggs, Victoria Richards Visiting Professor: ...... Kevin E. Driscoll 2002 ..... Kartik Shankar, Chad M. Vezina, Ryan L. Williams 1997 ...... University of New Mexico Health Sciences Center 2003 ...... Sachin Devi, Midhun Korrapati, Pallavi Limaye Visiting Professor: ...... Sam Kacew 2004 ...... Jaya Chilakapati 1997 ...... University of Illinois 2005 ...... Vishaka Bhave, Ankur Dnyanmote, Visiting Professor: ...... Michael Denison ...... Johnathan Maher 1998 ...... University of Washington 2006 ...... Mary Hassani, Prajakta Palkar Visiting Professor: ...... Bruce Fowler 1998 ...... San Diego State University Colgate-Palmolive Traveling Visiting Professor: ...... Leigh Ann Burns Naas Lectureship in Alternative Methods 1999 ...... San Diego State University Visiting Professor: ...... Robert Chapin in Toxicology Award 2000 ...... Yale University, School of Medicine The Colgate-Palmolive Company sponsors the Colgate- Visiting Professor: ...... Narendre Singh Palmolive Traveling Lectureship in Alternative Methods 2001 ...... Medical College of Wisconsin Visiting Professor: ...... Garold Yost in Toxicology Award annually through the Society of 2003 ...... Washington State University Toxicology. This award covers expenses for an individual Visiting Professor: ...... Marc W. Fariss scholar to visit institution(s) for the dissemination of knowl- 2004 ...... Snorri S. Thorgeirsson edge and for stimulating research that takes advantage of Institution to be Visited: ...... University of modern in vitro toxicology approaches. The overall goal ...... Louisiana at Monroe of this program is to make scientists aware of the benefits of modern in vitro toxicology approaches and to stimulate research for the replacement, reduction or refinement of currently used animal models. The scholar may be asked to make a special presentation at the SOT Annual Meeting. Contributions to Public Awareness of the Importance of Lecturing scholars should be established, mid-career through late-career scientists who are members of SOT and who are Animals in Toxicology Research Award developing collaborative relationships with scientists at other The Contributions to Public Awareness of the Importance institutions. of Animals in Toxicology Research Award is presented annually to an individual (or organization) in recognition Requests for funds can be made by the individual scholar or of the contributions made to the public understanding by organizations such as universities, colleges, SOT Specialty of the role and importance of experimental animals in Sections and SOT Regional Chapters, and other toxicology toxicological science. This award may be for either a single organizations that are interested in inviting the scholar. Up seminal piece of work or a longer-term contribution to to $15,000 is available. The Awards Committee reviews the public understanding of the necessity of the use of animals applications, which must be accompanied by a statement of
in toxicological research both to ensure and enhance the REFERENCE the applicant’s experience, a brief overview of the techniques quality of human and animal health and the environment. to be discussed in the lecture, and a letter from the hosting The award consists of a plaque and a cash stipend. institution(s) indicating their interest in serving as host and the potential benefits to the institution. Award Recipients Award Recipients 2000 ...... Allegheny-Erie Chapter 2001 ...... Massachusetts Society for Medical Research 1996 ...... University of Mississippi Medical Center 2002 ...... George Nethercutt Visiting Professor: ...... Tetsuo Satoh 2003 ...... Michael Derelanko 1996 ...... University of Illinois at Urbana 2004 ...... North Carolina Association for Visiting Professor: ...... Julio Davila ...... Biomedical Research (NCABR), 1996 ...... Mississippi State University ...... Americans for Medical Progress (AMP) Visiting Professor: ...... Michael Holsapple 2005 ...... Orrin G. Hatch, Foundation for 1996 ...... Washington State University ...... Biomedical Research Visiting Professor: ...... Daniel Acosta 2006 ...... Jayne Mackta up-to-date information at www.toxicology.org 293 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards 1996 ...... Robert Snyder 1997 ...... Albert E. Munson Distinguished Lifetime 1998 ...... David J. Holbrook Toxicology Scholar Award 1999 ...... Jules Brodeur 2000 ...... Gary Carlson The Distinguished Lifetime Toxicology Scholar Award is 2001 ...... Harihara Mehendale presented to a member of SOT who has made substantial 2002 ...... Joseph Borzelleca and seminal scientific contributions to the discipline of toxi- 2003 ...... Frederick W. Oehme cology. The prime consideration for this award is scientific 2004 ...... A. Jay Gandolfi accomplishments and not necessarily service to the Society. 2005 ...... Nobuyuki Ito This award consists of a plaque and a cash stipend. (This 2006 ...... Robert A. Schatz award was known in 2001 as the Scientific Achievement Award.)
Award Recipients Enhancement of Animal 2001 ...... James E. Troska Welfare Award 2003 ...... Henry C. Pitot 2004 ...... Gerald N. Wogan The Enhancement of Animal Welfare Award is presented 2005 ...... Daniel Nebert annually to a member of the Society in recognition of 2006 ...... Sten G. Orrenius the contribution made to the advancement of toxico- logical science through the development and application of methods that replace, refine, or reduce the need for experimental animals. This award recognizes outstanding/ Education Award significant contributions made by members of the Society of Toxicology to the sound and responsible use of animals The Education Award is presented to an individual who in scientific research. The achievement recognized may be is distinguished by the teaching and training of toxi- either a seminal piece of work or a long-term contribution cologists and who has made significant contributions to to toxicological science and animal welfare. The award education in the broad field of toxicology. This award consists of a plaque and a cash stipend. consists of a plaque and a cash stipend. Award Recipients Award Recipients 2000 ...... Yves Alarie REFERENCE 1975 ...... Harold C. Hodge 2001 ...... Alan Goldberg 1976 ...... Ted A. Loomis 2002 ...... Gary Williams 1977 ...... Robert B. Forney 2003 ...... G. Frank Gerberick, Ian Kimber 1979 ...... Sheldon D. Murphy 2005 ...... Daniel Acosta 1980 ...... Herbert H. Cornish 2006 ...... William S. Stokes 1981 ...... Frederick Sperling 1982 ...... Lloyd W. Hazleton Graduate Student Fellowship 1983 ...... Julius M. Coon 1984 ...... Frank Guthrie, Ernest Hodgson Award—Novartis Award 1985 ...... William B. Buck The Graduate Student Fellowship—Novartis Award is 1986 ...... Robert I. Krieger available for student members of the SOT engaged in full- 1987 ...... Gabriel L. Plaa time graduate study towards a Ph.D. degree in toxicology. 1988 ...... John Autian The major professor must be a SOT member. The evalu- 1989 ...... Tom S. Miya 1990 ...... Charles H. Hine ation is based primarily on originality of the dissertation 1991 ...... Hanspeter R. Witschi research, research productivity, relevance to toxicology, 1992 ...... Dean E. Carter scholastic achievement, and letters of recommendation. 1993 ...... Curtis D. Klaassen Finalists are interviewed at the Annual Meeting and 1994 ...... Robert A. Neal receive travel support. 1995 ...... William Carlton
294 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards Award Recipients Inductees 1989 ...... Timothy Zacharewski 1962 ...... Eugene M.K. Geiling* 1990 ...... Mary Suzanne Stefaniak 1962 ...... W. F. Von Oettingen* 1991 ...... Donald Bjerke 1962 ...... Torald H. Sollman* 1992 ...... Lhanoo Gunawardhana 1963 ...... Ethel Browning* 1993 ...... Christopher Martenson 1966 ...... R. Tecwyn Williams* 1994 ...... Nyla Harper 1976 ...... Norton Nelson* 1995 ...... Heather E. Kleiner 1982 ...... George H. Hitchings* 1996 ...... Russell Thomas 1986 ...... Bernard B. Brodie* 1997 ...... Melva Rios-Blancos 1986 ...... Herbert Remmer 1998 ...... Kent Carlson 1991 ...... Hyman J. Zimmerman* 1999 ...... Mark Hickman 1994 ...... Ronald W. Estabrook 2000 ...... Jeffrey Moran 1994 ...... Wendell W. Weber 2001 ...... Vishal Vaidya 1995 ...... Gertrude B. Elion* 2002 ...... Kartik Shankar 1995 ...... Charles S. Lieber 2003 ...... Sachin Devi 1996 ...... Sten G. Orrenius 2004 ...... James Luyendyk 1996 ...... Dennis Parke 2005 ...... Andrea W. Wong 1997 ...... John E. Casida 1997 ...... Roger W. Russell* (Recipients of Graduate Fellowship Awards no longer offered may 1998 ...... Jud Coon be found on the SOT Web site at www. toxicology.org.) 1998 ...... Michel Mercier 1999 ...... William O. Robertson 1999 ...... Takashi Sugimura 2000 ...... Findlay Russell 2001 ...... Herbert Needleman Graduate Student Travel Support Graduate Student Travel Support defrays expenses for Merit Award students presenting platform talks or posters at the SOT Annual Meeting. To be eligible, the student must be a SOT The Merit Award is presented to a member of the Society member (or have submitted a membership application) of Toxicology in recognition of a distinguished career in who has not previously received SOT graduate student toxicology. This award consists of a plaque and a cash travel support. stipend. Award Recipients 1966 ...... Henry F. Smyth, Jr. Honorary Membership 1967 ...... Arnold J. Lehman 1968 ...... R. T. Williams REFERENCE The Society of Toxicology recognizes non-members who 1969 ...... Harold C. Hodge embody outstanding and sustained achievements in the 1970 ...... Don D. Irish field of toxicology with the Honorary Member Award. 1971 ...... Kenneth P. DuBois Candidates are nominated by two voting or associate 1972 ...... O. Garth Fitzhugh members of the Society. Seconding letters and informa- 1973 ...... Herbert E. Stokinger 1974 ...... William B. Deichmann tion regarding career achievements in toxicology should 1975 ...... Frederick Coulston* accompany the nomination. A two-thirds vote of Council 1976 ...... Verald K. Rowe* determines recipients, with not more than two Honorary 1977 ...... Harry W. Hays Members elected during any one term of Council. 1978 ...... Julius M. Coon Nominations should be sent to SOT Headquarters. 1979 ...... David W. Fassett 1980 ...... Bernard L. Oser 1981 ...... John H. Weisburger 1982 ...... Harold M. Peck up-to-date information at www.toxicology.org 295 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards (Continued) 1983 ...... Perry J. Gehring* Pfizer Undergraduate Student Travel 1984 ...... Tom S. Miya 1985 ...... Carrol S. Weil Award 1986 ...... Ted A. Loomis 1987 ...... Bo Holmstedt Pfizer Undergraduate Student Travel Awards are presented 1988 ...... Seymour L. Friess through the Society of Toxicology to foster an interest in 1989 ...... Wayland J. Hayes, Jr.* graduate studies in the field of toxicology by bringing 1990 ...... Sheldon D. Murphy promising undergraduate students to the Society of 1991 ...... Toshio Narahashi Toxicology annual meetings. Pfizer, Inc. will provide up to 1992 ...... W. Norman Aldridge five awards per year to undergraduate students presenting 1993 ...... John Doull research at the Annual Meeting. Awardees will be selected 1994 ...... Ernest Hodgson based on the quality of the submitted abstract and their 1995 ...... Robert A. Scala advisor’s supporting recommendation. Those selected 1996 ...... Gabriel L. Plaa will receive travel assistance for the Meeting, a plaque 1997 ...... Mary O. Amdur presented at the annual Awards Ceremony, and recogni- 1998 ...... John A. Thomas 1999 ...... Thomas Clarkson tion at a special Pfizer function. Awardees will be matched 2000 ...... Philippe Shubik with a graduate student and a Pfizer scientist to mentor 2001 ...... Donald Reed them during the Meeting, and will have the opportu- 2002 ...... Bernard Schwetz nity to attend the Society of Toxicology Undergraduate 2003 ...... M.W. Anders Education Program on Sunday. 2004 ...... Robert Goyer 2005 ...... Roger McClellan Awards Recipients 2006 ...... A. Wallace Hayes 2006 ...... Shawntay Chaney, ...... Theresa M. Eagle, ...... Natalie Malek, ...... Adeliada Segarra, Minority Undergraduate ...... Ryan Vaughan Student and Advisor Awards The Minority Undergraduate Student and Advisor Awards provide support for awardees to participate in the Undergraduate Education Program at the SOT Annual Public Communications Award Meeting. This program is an introduction to the disci- The Public Communications Award is presented by the
REFERENCE pline of toxicology for undergraduate science majors Society of Toxicology to recognize an individual who and includes an orientation, a special poster session has made a major contribution to broadening the aware- with scientists, and activities with a SOT mentor. The ness of the general public on toxicological issues through travel awards are for those from races and ethnic groups any aspect of public communications. The award should under-represented in the sciences (African American, reflect accomplishments made over a significant period of American Indian or Hispanic American) and for their time. Examples of qualifying media in which the nomi- advisors. Advisors are eligible regardless of racial or ethnic nated communication may appear are: books, brochures, background. Meeting registration and support for travel, continuing education courses, data bases, extension lodging, and meals are provided for students and advisors bulletins, magazines, newspapers (local or national), who are not local to the meeting site. Students and advi- outreach, public presentations, public forums, radio and sors from local institutions receive meeting and program television scripts, and workshops. The award consists of a registration and meals. In the past, the program has been plaque and a cash stipend. supported in part by NIH-MARC, Pfizer, and Johnson & Johnson.
296 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Society of Toxicology Awards (Continued) Awards Recipients Award Recipients 1994 ...... Michael A. Kamrin 2002 ...... Christophor Dishovsky (Bulgaria), 1995 ...... Philip Abelson ...... Zoltan Gregus (Hungary), 1996 ...... Bruce N. Ames ...... Maritza Rojas Martini (Venezuela), 1997 ...... Audrey Gotsch ...... Choon-Nam Ong (Singapore), 1999 ...... Ann de Peyster ...... W. Wasowicz (Poland), Ping-kun Zhou (China) 2001 ...... Anna Shvedova 2003 ...... Jian-Hui Liang (China), 2002 ...... Sam Kacew ...... Marjan G. Vracko (Slovenia), 2003 ...... Charlene A. McQueen ...... Eman A. Seif (Egypt) 2004 ...... Kenneth Olden 2004 ...... Cristina Bolaton (Phillipines), 2005 ...... Robert Kreiger ...... P.K. Gupta (India), ...... Salmaan Inayat-Hussain (Malaysia), ...... Xianping Ying (China) 2005 ...... Diana B. Apostolova (Bulgaria), Regional Chapter Awards ...... Marite Arija Bake (Latvia), ...... Teresa I. Fortuoul (Mexico), Most SOT Regional Chapters provide awards to recognize ...... Mary Gulumian (South Africa), outstanding students or scientists. Application requirements ...... He Jiliang (China), and deadlines vary. Visit the Regional Chapter or Awards ...... Khalidya Khamidulina (Russia), and Fellowship section on the SOT Web site for full details...... L. Orish Orisakwe (Nigeria), ...... Songsak Srianujata (Thailand), ...... Sinan Suzen (Turkey) 2006 ...... Olanike Adeyemo (Nigeria), ...... Deepak Argwal (India), Society of Toxicology/ ...... Carlos Colangelo (Argentina), American Chemistry Council Early ...... Sandra Demichelis (Argentina), Career Award ...... Mumtaz Iscan (Turkey), ...... Karolina Lyubomirova (Bulgaria), The American Chemistry Council offered an Early Career ...... Osman Aly Osman (Egypt), Award through the Society of Toxicology. The award ...... Shuang-Qing Peng (China), was up to $100,000 and designed to encourage persons ...... Julia Radenkova-Saeva (Bulgaria) beginning their professional careers to conduct research that will improve the scientific basis for risk assessment and decision making with respect to a particular specialty area of potential toxicity of chemicals. Awards have been offered in Inhalation and Neurotoxicology. Specialty Section Student Awards Award Recipients Most SOT Specialty Sections provide awards to recognize 2002 ...... Ronald Tjalkens (Neurotoxicololgy) REFERENCE outstanding student presentations at the SOT Annual 2003 ...... Ilona Jaspers (Inhalation) Meeting. Application requirements and deadlines vary. 2004 ...... Nikolay Filipov (Neurotoxicololgy) For more details refer to the Award descriptions on the SOT Web site at www.toxicology.org, under Specialty Sections or the Awards and Fellowships section.
SOT/IUTOX AstraZeneca Fellowship The AstraZeneca company, in conjunction with SOT, spon- sors a travel fellowship award annually through SOT and IUTOX. Awards will be available to senior scientists from a country where toxicology is underrepresented to assist with travel to attend the Society of Toxicology Annual Meeting. up-to-date information at www.toxicology.org 297 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Toxicology Specialists The Society of Toxicology has established a Toxicology Specialists Program to assist journalists and members of the public in identifying or locating expert toxicologists who can provide factual information on issues of public concern. These Toxicology Specialists provide information based on their own credentials and do not represent the views of the Society of Toxicology. For further information, please contact SOT Headquarters at (703) 438-3115, or e-mail: [email protected].
Specialities: In Vitro Mechanisms Regulatory Toxicology/ Daniel Acosta, Jr. Jane A. S. Allen Regulatory Affairs/ Carcinogenesis Yvonne Dragan Daniel Acosta, Jr. Safety Evaluation Elaine M. Faustman William Berndt Jane A. S. Allen Jane A. S. Allen Jay Gandolfi Linda Birnbaum James Bond Daniel Acosta, Jr. (drugs/ Kenneth S. Ramos Gary P. Carlson Richard Bull addictive agents) Rick Schnellmann George B. Corcoran Yvonne Dragan Gregory Allgood Jacqueline H. Smith Ann de Peyster David L Eaton Richard Bull Yvonne Dragan James E. Klaunig Jack Dean (drugs) Inhalation/Pulmonary Elaine M. Faustman Michael McClain Michael Dourson Barbara Beck Jay Gandolfi Charlene A. McQueen Robin Goldstein (drugs) James Bond James E. Klaunig Henry Pitot Robert A. Kuna Gary Boorman (pulmonary Lois D. Lehman-McKeeman James Popp James Lamb (pesticides and pathology) Jose E. Manautou Jacqueline H. Smith industrial chemicals) Robert Drew Hari Mehendale Cheryl Lyn Walker Michael McClain (drugs) Roger McClellan James Popp Kathleen Rodgers (drugs) Comparative and John Morris Kenneth S. Ramos Robert Phalen Stephen Safe Veterinary Reproductive/ Gary Yost Rick Schnellmann Developmental Roger McClellan Ellen Silbergeld Robert Chapin Kidney Toxicity Kendall B. Wallace George Daston Epidemiology William Berndt Gary Yost Ellen Silbergeld Ann de Peyster Steven D. Cohen Elaine M. Faustman Mary Davis Metabolism/ General Toxicology Carole A. Kimmel Ernest Foulkes Toxicokinetics James Lamb Jane A. S. Allen Jay Gandolfi Linda Birnbaum Hugh Tilson (developmental Linda Birnbaum Robin Goldstein George B. Corcoran neurotoxicology) Yvonne Dragan Lois D. Lehman-McKeeman Lois D. Lehman-McKeeman David L. Eaton Rick Schnellmann Raymond Novak Risk Assessment Sidney Green Liver Toxicity Barbara Beck James E. Klaunig Steven D. Cohen REFERENCE Molecular Michael Bolger Robert Krieger George B. Corcoran Elaine M. Faustman James Bond Michael McClain Mary Davis William Greenlee Richard Bull Kendall B. Wallace Yvonne Dragan Norbert Kaminski John Christopher Jay Gandolfi Genetic Toxicology Henry Pitot Rory Conolly Robin Goldstein Kenneth S. Ramos Michael Dourson Jane A. S. Allen James E. Klaunig Raymond Novak Elaine M. Faustman Sidney Green Jose E. Manautou (cell signaling, gene Jay I. Goodman James E. Klaunig Hari Mehendale expression) Carole A. Kimmel Charlene A. McQueen James Popp Kendall B. Wallace Robert A. Kuna (environmental) Gary Yost James Lamb Cheryl Lyn Walker Roger McClellan Neurotoxicity Jacqueline H. Smith Immunotoxicology Marion F. Ehrich Scott Burchiel Robert Krieger Jack Dean Joel Mattsson Jay Gandolfi (hypersensitivity) Ellen Silbergeld Norbert Kaminski William Slikker Nancy Kerkvliet Hugh Tilson Kathleen Rodgers Mary Jane Selgrade
298 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Toxicology Specialist (Continued) Issues: Food Additives/ Water Pollution North Carolina Food Safety/ Richard Bull Linda Birnbaum Air Pollution Food Toxins James Bond Gary Boorman James Bond Michael Dourson Regional Rory Conolly Robert Drew (air quality David L. Eaton (especially William Greenlee standards) aflatoxins) Distribution: H. B. Matthews Roger McClellan (air quality Robert A. Kuna standards-environmental Central States Mary Jane Selgrade Hugh Tilson and occupational) Free Radicals/ William Berndt (NE) John Morris Oxidative Stress/ Northeast Robert Phalen Antioxidants Gulf Coast (Texas) Mary Jane Selgrade Barbara Beck (MA) James Kehrer Stephen Safe Robert Chapin (CT) Animal Studies/ James E. Klaunig Cheryl Lyn Walker Steven D. Cohen (MA) Kendall B. Wallace Animals in Research Lois D. Lehman-McKeeman Michigan (NJ) Gary Boorman Industrial Chemical James S. Bus Jose E. Manautou (CT) Stephen DiZio Toxicology George B. Corcoran John Morris (CT) Robert Phalen James S. Bus Jay I. Goodman James A. Popp (CT) Norbert Kaminski Biotechnology/ Robert A. Kuna Kendall B. Wallace Raymond Novak Northern California Biopharmaceutical John Christopher Toxicology Medical Devices Mid-Atlantic Stephen DiZio Scott Burchiel Scott Burchiel Jack Dean (PA) Kathleen Rodgers Michael Gallo (NJ) Ohio Valley or Chemical-Chemical Stephen Safe Robin Goldstein (NJ) Allegheny-Erie Robert A. Kuna (NJ) Interactions Daniel Acosta, Jr. (OH) Michael McClain (NJ) Steven D. Cohen Metals George Daston (OH) James Popp (PA) Jay Gandolfi Barbara Beck Mary Davis (WV) William Berndt Midwest Michael Dourson (OH) Chlorine-Based Michael Bolger Ernest Foulkes (OH) Compounds Ernest Foulkes James E. Klaunig (IN) Kenneth S. Ramos (KY) Joel Mattsson (IN) Richard Bull Jay Gandolfi Henry Pitot (WI) Rory Conolly Hugh Tilson (lead, methyl Pacific Northwest mercury) Kendall B. Wallace (MN) Jay Gandolfi (also fluorine Richard Bull (WA) compounds) Mountain West David L. Eaton (WA) James E. Klaunig Natural Toxins Elaine M. Faustman (WA) Scott Burchiel (NM) H. B. Matthews Michael Bolger James Kehrer (WA) Jay Gandolfi (AZ) Hugh Tilson (PCBs) Joel Mattsson Nancy Kerkvliet (OR) Roger McClellan (NM) Dioxins/PCBs Pesticides Charlene A. McQueen (AZ) South Central Gary Yost (UT) Linda Birnbaum James S. Bus Janice E. Chambers (MS) Marion F. Ehrich Michael Bolger National Capital Yvonne Dragan (AR) Rory Conolly Robert Krieger Hari Mehendale (LA) James Lamb Michael Bolger (DC) David L. Eaton William Slikker (AR) REFERENCE Robert Drew (VA) William Greenlee H. B. Matthews Marion F. Ehrich (VA) Norbert Kaminski Kathleen Rodgers Southeastern Sidney Green (DC) Nancy Kerkvliet Stephen Safe Bruce A. Fowler (GA) Michael P. Holsapple (DC) Kenneth S. Ramos Rick Schnellmann (SC) Carole A. Kimmel (MD) Ellen Silbergeld Radiation James Lamb (DC) Hugh Tilson Gary Boorman (EMF exposure) Southern California Ellen Silbergeld (MD) Mary Jane Selgrade Ann de Peyster Jacqueline H. Smith (MD) Endocrine Disrupters Robert Krieger Linda Birnbaum Solvents Robert Phalen Michael Bolger Mary Davis Kathleen Rodgers James S. Bus Robert Chapin Validation of Alternative Rory Conolly Methods Michael Gallo Nancy Kerkvliet Sidney Green James Lamb Cheryl Lyn Walker up-to-date information at www.toxicology.org 299 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Headquarters Staff Staff Contact Extension E-Mail Activity
Shawn Douglas Lamb 1444 [email protected] Executive Director
Clarissa Russell Wilson 1455 [email protected] Deputy Executive Director
Rosibel Alvarenga 1432 [email protected] Membership
Jessica Canning 1443 [email protected] Administration
Mia Delaney 1440 [email protected] Accounting
Betty Eidemiller 1430 [email protected] Animals in Research Education Programs Student and Post-Doctoral Programs
Veronica Fisher 1450 [email protected] Accounting
Crystal Furr 1423 [email protected] Exhibits/Meetings Administration
Sally Horn 1402 [email protected] Education Programs
Libby Jones 1454 [email protected] Exhibits
Sonia Karim 1426 [email protected] Publications World Wide Web
Teresa Kirkhart 1438 [email protected] Registration
Marcia Lawson 1446 [email protected] Career Resource and Development Membership Regulatory Affairs and Legislative Assistance
Tierre Miller 1451 [email protected] Career Resource and Development Membership
Tonia Masson 1433 [email protected] Administration
Deborah O’Keefe 1441 [email protected] Publications World Wide Web REFERENCE Sue Pitsch 1442 [email protected] Administration
Heidi Prange 1424 [email protected] Meetings
Lilly Richards 1454 [email protected] Media
Becca Rhame 1447 [email protected] Administration
Rita Rose 1434 [email protected] 45th Anniversary Task Force Historian Regional Chapters Specialty Sections
Nichelle Sankey 1431 [email protected] Continuing Education Program Committee
Elisa Turner 1445 [email protected] Publications World Wide Web
Society of Toxicology Headquarters 1821 Michael Faraday Drive, Suite 300, Reston, Virgina 20190 Tel: (703) 438–3115; Fax: (703) 438-3113 E-Mail: [email protected]; Web site: www.toxicology.org 300 SOT's 45th Annual Meeting 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo (Norbert E. Kaminski, Council Liaison)
SOT Affiliates SOT Affiliates have no voting rights or other special priveleges. Abbott Laboratories ChevronTexaco Energy Hoffmann-La Roche, Inc. Abbott Park, Illinois Research & Technology Nutley, New Jersey Company Agilent Technologies, Inc. Honeywell International, Inc. Richmond, California Wilmington, Delaware Morristown, New Jersey Chlorine Chemistry Council Alcon Research, Ltd. Johnson & Johnson Arlington, Virginia Fort Worth, Texas Raritan, New Jersey CIIT Centers for Health American Chemistry Council Johnson & Johnson Research Arlington, Virginia Corporation Research Triangle Park, New Brunswick, New Jersey American Petroleum Institute North Carolina Washington, D.C. Merck & Company, Inc. Coca Cola Company West Point, Pennsylvania Ani Lytics, Inc. Atlanta, Georgia Gaithersburg, Maryland Novartis Pharmaceuticals Colgate Palmolive Company Corporation AstraZeneca R&D Piscataway, New Jersey East Hanover, New Jersey Södertälje, Sweden Covance, Inc. Pfizer, Inc. BASi Evansville Madison, Wisconsin New London, Connecticut Mount Vernon, Indiana The Dial Corporation The Procter & Gamble Bayer Scottsdale, Arizona Company Stilwell, Kansas Dow Chemical Company Cincinnati, Ohio Berlex Laboratories, Inc. Midland, Michigan RTC Research Toxicology Montville, New Jersey E. I. DuPont de Nemours Centre S.P.A Biogen Idec, Inc. & Company Pomezia, Rome Cambridge, Massachusetts Newark, Delaware Sankyo Company, Ltd. Boehringer Ingelheim Eastman Chemical Company Shizuoka, Japan Pharmaceuticals, Inc. Kingsport, Tennessee sanofi-aventis Ridgefield, Connecticut Eastman Kodak Company Bridgewater, New Jersey Bristol-Myers Squibb Rochester, New York Schering-Plough Research Company Eli Lilly & Company Institute New Brunswick, Indiana REFERENCE Indianapolis, Indiana Kenilworth, New Jersey CANTOX ExxonMobil Biomedical Sequani, Ltd. Mississauga, Ontario, Canada Sciences, Inc. Ledbury, Herefordshire Charles River Laboratories Annandale, New Jersey Southern Research Institute Wilmington, Massachusetts Genentech, Inc. Birmingham, Alabama Chevron Phillips Chemical South San Francisco, California WIL Research Laboratories, Company, LP Gillette Company LLC. The Woodlands, Texas Needham, Massachusetts Ashland, Ohio
GlaxoSmithKline Wyeth Ayerst Research King of Prussia, Pennsylvania Chazy, New York up-to-date information at www.toxicology.org 301 45th Annual 45th Annual MeetingMeeting & ToxExpo and ToxExpo Notes:
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up-to-date information at www.toxicology.org 311 The 46th SOT Annual Meeting will be held in Charlotte, North Carolina March 25–29, 2007
Deadline for Proposals for SOT 2007 Annual Meeting Sessions: April 30, 2006
Photos courtesy of Visit Charlotte. All text and graphics © 2006 by the Society of Toxicology unless noted.
WHY SUBMIT A PROPOSAL? SESSION TYPES Continuing Education—Emphasis on quality 1. To present new developments in toxicology. presentations of generally accepted, state-of- the-art knowledge in toxicology 2. To provide attendees an opportunity to learn about Note: CE Courses will be held on Sunday. state-of-the-art technology and how it applies to Symposia—“Cutting-edge” science; new areas, toxicological research. concepts, or data Workshops—State-of-the-art knowledge in 3. To provide attendees an opportunity to learn about the toxicology Roundtables—Controversial subjects emerging fields and how they apply to toxicology. Historical Highlight—Review of a historical body of science that has impacted toxicology You can now submit your proposal on-line at Member Services—Scientific planning or www.toxicology.org membership development
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