International Journal of Molecular Sciences Article Structure–Function Relationship of Retinal Ganglion Cells in Multiple Sclerosis Khaldoon O. Al-Nosairy 1, Marc Horbrügger 2, Sven Schippling 3,4 , Markus Wagner 1, Aiden Haghikia 5, Marc Pawlitzki 6,† and Michael B. Hoffmann 1,7,*,† 1 Department of Ophthalmology, University Hospital Magdeburg, 39120 Magdeburg, Germany 2 Department of Dermatology, University Hospital Magdeburg, 39120 Magdeburg, Germany 3 Multimodal Imaging in Neuro-Immunological Diseases (MINDS), University of Zurich, 8057 Zurich, Switzerland 4 Center for Neuroscience Zurich (ZNZ), ETH Zurich, 8057 Zurich, Switzerland 5 Department of Neurology, University Hospital Magdeburg, 39120 Magdeburg, Germany 6 Department of Neurology, Institute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany 7 Center for Behavioral Brain Sciences, 39120 Magdeburg, Germany * Correspondence:
[email protected]; Tel.: +49-391-6713585 † Shared senior authorship. Abstract: The retinal ganglion cells (RGC) may be considered an easily accessible pathophysiological site of degenerative processes in neurological diseases, such as the RGC damage detectable in multiple sclerosis (MS) patients with (HON) and without a history of optic neuritis (NON). We aimed to assess and interrelate RGC functional and structural damage in different retinal layers and retinal sites. We included 12 NON patients, 11 HON patients and 14 healthy controls for cross-sectional multifocal Citation: Al-Nosairy, K.O.; pattern electroretinography (mfPERG) and optical coherence tomography (OCT) measurements. Horbrügger, M.; Schippling, S.; Wagner, Amplitude and peak times of the mfPERG were assessed. Macula and disc OCT scans were acquired M.; Haghikia, A.; Pawlitzki, M.; to determine macular retinal layer and peripapillary retinal nerve fiber layer (pRNFL) thickness.