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PR Domain Containing 2 (PRDM2) Is a Tumor Suppressor Protein

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PR Domain Containing 2 (PRDM2) Is a Tumor Suppressor Protein PRDM2, PR domain containing 2 polyclonal antibody R domain containing 2 (PRDM2) is a tumor suppressor protein and a founding member of the PR domain family. It encodes or Research Use Only. Not for P FDiagnostic or Therapeutic Use. a zinc finger protein that can bind to retinoblastoma protein, Purchase does not include or carry estrogen receptor, and the TPA-responsive element (MTE) of any right to resell or transfer this the hemeoxygenase- 1 gene. Although the biological function product either as a stand-alone of PRDM2 has not been fully characterized, (i) it may play a role product or as a component of another in transcriptional regulation during neuronal differentiation and product. Any use of this product other pathogenesis of retinoblastoma, (ii) act as a transcriptional activator than the permitted use without the of the heme-oxygenase- 1 gene, and (iii) be a specific effector express written authorization of Allele of estrogen action. PRDM2 inactivation is commonly found in Biotech is strictly prohibited many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. PRDM2 is also a tumor susceptibility gene in Website: www.allelebiotech.com mice. The loss of PRDM2 mRNA in human cancers was shown to be Call: 1-800-991-RNAi/858-587-6645 associated with DNA methylation of the CpG island of its promoter. (Pacific Time: 9:00AM~5:00PM) Methylation of the PRDM2 promoter strongly correlates with lost Email: [email protected] or decreased PRDM2 expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues. PRDM2 has potential role in the multistep tumor forming process of malignant melanoma of the skin. Box 1 | Basic Info Buffers Cat. No. ABP-PAB-10302 Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column Animal ID HS1637 and eluted out with both high and low pH buffers and neutralized Host Rabbit immediately after elution then followed by dialysis against PBS. Reactivity Human, Primates, Rodents (mouse and rat ) Immunogen Format Purified Purified recombinant GST fusion protein encoding aa 245-573 of rat RIZ1. Accession number NM_012231 Amount 100 μg Application: Tested by peptide-specific ELISA (1:1,000). WB: 1:100~1:500 Alternative Name(s): RIZ, RIZ1, RIZ2, MTB- Immunoprecipitation: 1 ug ZF, HUMHOXY1, MTE-binding protein zinc- finger DNA-binding protein, retinoblastoma Storage: protein-binding zinc finger protein Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store ar -20°C. Avoid repeated freeze-thaw cycles. References: 1. Steele-Perkins G, Fang W, Yang XH, Van Gele M, Carling T, Gu J, Buyse IM, Fletcher JA, Liu J, Bronson R,Chadwick RB, de la Chapelle A, Zhang X, Speleman F, Huang S.: Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein- methyltransferase superfamily. Genes Dev. 15: 2250-2262 (2001). 2. Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T: Nucleotide alteration of retinoblastoma protein interacting zinc finger gene, RIZ, in human leukemia. Tohoku J. Exp. Med. 196: 193-201 (2002). 3. Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S: Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res. 61: 8094- 8099 (2001). 4. Canote R, Du Y, Carling T, Tian F, Peng Z, Huang S: The tumor suppressor gene RIZ in cancer gene therapy (review). Oncol. Rep. 9: 57-60 (2002), review. 5. Poetsch M, Dittberner T, Woenckhaus C: Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36. Oncogene 21: 3038-3042 (2002). Allele Biotech-Introducing Cost Effectiveness to Research.
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