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2011-2012 Annual Report 2011-2012 2 Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary Information Director’S and Chairman’S Report

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2011-2012 Annual Report 2011-2012 2 Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary Information Director’S and Chairman’S Report Annual Report 2011-2012 Supplementary information Contents 1 About the institute 99 Engagement 3 Director’s and Chairman’s report 101 Strategic partners 5 Discovery 102 Scientific and medical community 8 Cancer and Haematology 104 Public engagement 12 ACRF Stem Cells and Cancer 107 Donor and bequestor engagement 16 Molecular Genetics of Cancer 109 Service to the scientific and wider community 20 ACRF Chemical Biology 118 Sustainability 24 Molecular Medicine 119 The Board 28 Structural Biology 123 Chief Operating Officer’s report 32 Bioinformatics 126 Supporters and donors 36 Infection and Immunity 131 Institute organisation 40 Immunology 132 Members of the institute 44 Cell Signalling and Cell Death 133 Staff list 48 Inflammation 136 Committees 52 Molecular Immunology 140 The year at a glance 56 Systems Biology and Personalised Medicine 141 Financial statements 59 Publications 168 Statistical summary 74 Awards 169 Capital Funds 75 Translation 76 Translating our research 78 Developing our research 80 Patents granted in 2011-2012 81 Education 84 2011-12 graduates 85 2011-12 PhD in progress 88 Bachelor of Science (Honours) in progress 89 2011-12 vacation scholars 90 Seminars 91 2011-12 institute speakers 93 2011-12 visiting speakers 96 2012 postgraduate lecture series 98 Institute awards Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary information Annual Report 2011-2012 Supplementary information CANCER | CHRONIC INFLAMMATORY DISEASE | INFECTIOUS DISEASE Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary information The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville Victoria 3052 Australia Telephone: (+61 3) 9345 2555 Facsimile: (+61 3) 9347 0852 WEHI Biotechnology Centre 4 Research Avenue La Trobe R&D Park Bundoora Victoria 3086 Australia Telephone: (+61 3) 9345 2200 Facsimile: (+61 3) 9345 2211 www.wehi.edu.au www.facebook.com/WEHIresearch www.twitter.com/WEHI_research ABN 12 004 251 423 © The Walter and Eliza Hall Institute of Medical Research 2012 Acknowledgements Produced by the institute’s Community Relations department Managing editor: Penny Fannin Editor: Liz Williams Writers: Liz Williams and Vanessa Solomon Design and production: Simon Taplin Photography: Czesia Markiewicz and Cameron Wells Cover image A still taken from the WEHI.TV animation X Inactivation and Epigenetics www.wehi.edu.au/x_inactivation_and_epigenetics Etsuko Uno and Drew Berry, WEHI.T V X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying epigenetics. Epigenetics refers to processes that tell our cells how, and when, to read the DNA blueprint. The epigenetic regulation of DNA is critical in both normal development and disease. Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary information About the institute Our mission Key objectives Mastery of disease through discovery Discovery: to make discoveries in medical biology that shape contemporary thinking and paradigms and Our vision enhance the understanding and treatment of disease To be an innovative medical research institute Translation: to convert our discoveries into that engages and enriches society and improves improvements in disease diagnosis, prevention health outcomes through discovery, translation and treatment and education Education: to develop and enrich the skills and experience of students and staff, allowing each Research themes person to realise their potential and contribute to a vibrant campus Cancer Engagement: to engage with the community and Chronic inflammatory disease develop support for medical research generally and the institute’s mission specifically Infectious disease Sustainability: to build an infrastructure, funding and research capacity that enables the institute to fulfil its mission in a sustainable manner An exterior view of the redeveloped Parkville campus. Walter and Eliza Hall Institute Walter and Eliza Hall InstituteAnnual Report Annual 2011-2012 Report 2011-2012 1 1 Supplementary information The Walter and Eliza Hall Institute is home to more than 650 Director researchers who are working to understand, prevent and treat Douglas J Hilton diseases including cancer, particularly blood, breast, lung, BSc Mon BSc(Hons) PhD Melb FAA ovarian and colon cancers; chronic inflammatory diseases Assistant Director such as type 1 diabetes, rheumatoid arthritis and coeliac David Vaux disease; and infectious diseases such as HIV and malaria. MB BS BMedSc PhD Melb FAA We are committed to making fundamental discoveries about the way cells, particularly cancer and blood cells, behave and communicate and seeing Chief Operating Officer these discoveries translated into benefits for patients. Maureen O’Keefe The institute was founded in 1915 as a benevolence of the Walter and BSc(Hons) Mon DipEd MBA Melb Eliza Hall Trust to be ‘the birthplace of discoveries rendering signal service GAICD WCLP to mankind in the prevention and removal of disease and the mitigation of suffering’. Company Secretary We are affiliated with The University of Melbourne and The Royal Melbourne Murray Jeffs Hospital and offer postgraduate training as the Department of Medical BBus(Accounting) RMIT CPA FCIS SF Fin Biology of The University of Melbourne. Honorary Governor and Patron Sir Gustav Nossal AC CBE MB BS BSc(Med) Syd PhD Melb HonLLD Mon HonLLD Melb HonMD Mainz HonMD Ncl HonMD Leeds HonMD UWA HonDSc Syd HonDSc Qld HonDSc ANU HonDSc UNSW HonDSc LaT HonDSc McMaster Clinician-scientist Dr Kylie Mason, laboratory head Professor Don Metcalf, senior HonDSc Oxon FRCP FRACP postdoctoral scientist Dr Catherine Carmichael and PhD student Mr Michael White (from left to right) from the institute’s Cancer and Haematology division are studying FRCPA FRACOG(Hon) FRCPath blood cells and their production, and what goes awry in the development of blood FRACGP FRSE FTSE FAA FRS cancers such as leukaemias and lymphomas. Walter and Eliza Hall Institute 2 Walter and Eliza Hall Institute Annual Report 2011-2012 Annual Report 2011-2012 2 Walter and Eliza Hall Institute Annual Report 2011-2012 Supplementary information Director’s and Chairman’s report The past 12 months have been a landmark for the Walter and Eliza Hall Institute. We have completed a $185 million building project, which has seen construction of a new west wing and a complete renovation of the east wing of the institute. The result is a doubling of our laboratory space and an integrated, state- of-the-art biomedical research facility that will continue to be a magnet for talented scientists who will make extraordinary discoveries. Funding a project of this scale and completing it on time and under budget is a feat that took vision, professionalism and discipline. ▶ The vision of the Australian and Victorian Governments, Mr Chuck Feeney and The Atlantic Philanthropies, The Ian Potter Foundation, Australian Cancer Research Foundation and Drakensburg Trust who all contributed generously to funding the capital works. ▶ The professionalism of all those involved in design and construction at Denton Corker Marshall, S2F/SKM, Baulderstone and Aurecon. ▶ The discipline of our own management team, especially Mike Fitzpatrick and Tony Murphy who provided sage leadership of our new building sub-committee that has had oversight of the project for the board, as well as Maureen O’Keefe, Steve Droste and their teams in the institute who have managed the program day-to-day. At this time, we should remember that the new building is not a fortress or an island, rather it is a magnificent base with which to interact with our partners in the Parkville precinct, and the wider community. The institute could not be better positioned to perform world-class medical research. We are situated within a short distance of four major hospitals: The Royal Melbourne Hospital, Royal Women’s Hospital, Royal Children’s Hospital and Peter MacCallum Cancer Centre (which will soon relocate to Institute director Professor Doug Hilton (left) with board the Victorian Comprehensive Cancer Centre building being erected on the president Mr Leon Davis Walter and Eliza Hall Institute Walter and Eliza Hall Institute Annual Report 2011-2012 Walter and Eliza Hall InstituteAnnual Report Annual 2011-2012 Report 2011-2012 3 3 Supplementary information old dental hospital site on Grattan colleagues in a range of departments an increasing number of discovery Street). Each of these hospitals is and allows The University of tours. At these tours members of a centre of excellence in patient Melbourne students, who are the public get to know us and join care, research and education, and among the brightest young minds the ever-growing institute family. To each is a highly valued partner as in Melbourne, to participate in the deliver the results that the investment we work to translate the discoveries institute’s research as Undergraduate in the new building merits, we need we make in the laboratory to Research Opportunities Program the community to be passionate improvements in disease prevention, (UROP) scholars, bachelor of advocates for medical research diagnosis and treatment that benefit science honours students and PhD and to be passionate supporters our community. students. We should remember of our own research effort. In our We are also situated opposite the that over the past 97 years, our experiences, as president of the world-class University of Melbourne, students have made many of our board and director of the
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