TA8443 Phospho-MER/TYRO3 (Tyr753/Tyr685) Antibody Order 021-34695924 [email protected] Support 400-6123-828 50ul [email protected] 100 uL √ √ Web www.ab-mart.com.cn

Description: Receptor that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)- mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Uniprot:Q12866 Alternative Names： c MER; c mer proto oncogene tyrosine kinase; c-mer; cMER; cmer protooncogene tyrosine kinase; Eyk; MER; MER ; MERK; MERPEN; Mertk; MERTK c-mer proto-oncogene tyrosine kinase; MERTK_HUMAN; MGC133349; nmf12; Nyk; Proto oncogene tyrosine MER; Proto oncogene tyrosine protein kinase MER precursor; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; RP38; STK kinase; Tyrosine-protein kinase Mer; Brt; BYK; DTK; Etk-2; protein tyrosine kinase 3; Rek; RSE; SKY; Tif; tyro3; TYRO3 protein tyrosine kinase; TYRO3_HUMAN; Tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine- protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; Specificity: Phospho-MER/TYRO3 (Tyr753/Tyr685) Antibody detects endogenous levels of MER/TYRO3 only when phosphorylated at Tyr753/Tyr685.

Reactivity:Human, Mouse, Rat

Source:Rabbit

Mol.Wt.: 110kD; 110kDa,97kDa(Calculated).

Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt.

Application: WB 1:1000-1:2000；IHC/IF 1:50-1:500