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Facilities and Other Resources - Overall FACILITIES AND OTHER RESOURCES - OVERALL The necessary infrastructure at the University of Utah (prime performance site) and other participating sites (Table 1) are available to support the application, Utah Center for Clinical and Translational Science (Utah CCTS). The assembled team for this innovative center is comprised of experienced principal investigators, mentors and other stakeholders committed to supporting the vision and mission of the Clinical and Translational Science Award (CTSA) consortium. The Principal Investigators, Co-Investigators, and other personnel have the necessary organizational and administrative infrastructure to successfully develop, implement, and evaluate center programs to support the national CTSA consortium. Table 1. Utah CCTS Facilities and Other The Genetic Science Learning Center 4.A Resources Office for Equity and Diversity 4.B Resource Section Center for Law and Biomedical Sciences 4.C Intermountain West 1 The Center for Medical Innovation 4.D The Intermountain West 1.A Vice President’s Clinical & Translational 4.E State of Utah 1.B Scholars Program Salt Lake City 1.C University of Utah Molecular Medicine 4.F University of Utah (U of Utah) and 2 Program University of Utah Health (U Health) Department of Population Health 4.G University Hospital 2.A Sciences Community Clinics 2.B Department of Biomedical Informatics 4.H Huntsman Cancer Institute (Laboratory) 2.C • Biomedical Natural Language • Cancer Biostatistics 2.C.1 Processing 4.H.1 • Pedigree and Population Resource 2.C.2 Entertainment Arts and Engineering 4.I Huntsman Cancer Hospital 2.D Program and GApp Lab University Orthopaedic Center 2.E U Health Core Facilities 5 University Neuropsychiatric Institute 2.F Administration 5.A John A. Moran Eye Center 2.G Biomedical Image and Data Analysis 5.B Cardiovascular Center 2.H Core Clinical Neurosciences Center 2.I Cell Imaging Facility 5.C Utah Diabetes and Endocrinology 2.J Centralized Zebrafish Animal Resource 5.D Center DNA Peptide Facility 5.E School of Medicine 2.K DNA Sequencing Facility 5.F School of Dentistry 2.L Drug Discovery Facility 5.G College of Health 2.M Electron Microscopy 5.H College of Nursing 2.N Flow Cytometry Facility 5.I College of Pharmacy 2.O Genomics Facility 5.J Additional U Health Resources 3 Machine Shop 5.K University of Utah Institutional Review 3.A Mass Spectrometry and Proteomics 5.L Board Metabolic Phenotyping 5.M Office of Sponsored Projects 3.B Metabolomics Facility 5.N Technology & Venture 3.C Mutation Generation & Detection Facility 5.O Commercialization Nuclear Magnetic Resonance Core 5.P Telemedicine Capabilities 3.D Facility Utah Population Database 3.E Small Animal Imaging Facility 5.Q Information Technology Services 3.F Small Animal Ultrasound Facility 5.R • Enterprise Data Warehouse 3.F.1 Utah Nuclear Engineering Facility 5.S • MyChart 3.F.2 Scalable Analytics & Informatics 5.T • Value Driven Outcomes 3.F.3 Cell Therapy and Regenerative 5.U • Center for High Performance 3.F.4 Medicine Program Computing • Blood & Marrow 5.U.1 • Network 3.F.5 Collection/Processing Services & ARUP Laboratories 3.G Activities Path PCORnet clinical Data Research 3.H • Product Development & 5.U.2 Network Translational Research 5.U.3 Eccles Health Sciences Library 3.I • Contract Manufacturing • 5.U.4 Supporting U Health Academic 4 Novel Cellular Therapy Clinical Trial Initiatives and Resources Support Utah CCTS Cellular Translational 5.V • Enterprise Data Warehouse 7.E.8 Research Core • Clinical Information Systems 7.E.9 U Health Regional Affiliate Network 6 • Knowledge Management 7.E.10 U Health Regional Affiliate Network 6.A • Intermountain Health Answers 7.E.11 Intermountain Healthcare 7 • CV DNA Lab 7.E.12 (Intermountain) • Intermountain Biorepository 7.E.13 Intermountain Hospitals 7.A • Intermountain Communications 7.E.14 7.E.15 Intermountain Ambulatory Clinics 7.B • Transformation Laboratory Intermountain Instacares/Emergency 7.C • Select Health Departments Veterans Affairs Salt Lake City 8 Clinical Programs & Specialties 7.D Healthcare System (VA) • Cardiovascular 7.D.1 Veteran’s Affairs Salt Lake City Health 8.A • Pulmonary Critical Care 7.D.2 Care System • Oncology 7.D.3 George E. Wahlen VA Medical Center 8.B • Maternal Fetal Medicine 7.D.4 VA Informatics and Computing 8.C • Neonatal Intensive Care Unit 7.D.5 Infrastructure • Pediatrics HealthInsight 9 7.D.6 • Surgical Services Laboratory 9.A 7.D.7 • Internal Medicine Animal 9.B 7.D.8 • Orthopedics 7.D.9 Computer 9.C • Emergency Medicine Department 7.D.10 • Hardware 9.C.1 • Screening Clinics 7.D.11 • Networks 9.C.2 • Family Practice 7.D.12 • Data Storage, Backup, and Access 9.C.3 Core Services Provided by 7.E Rights Intermountain Office 9.D • Office of Research 7.E.1 Clinical 9.E • Institutional Review Board 7.E.2 Biohazards 9.F • Institute for Healthcare Leadership 7.E.3 Clinical Faces of Utah (CFU) 10 • Clinical Genetics Institute 7.E.4 Utah Department of Health (UDoH) 11 • Intermountain Homecare 7.E.5 Utah All Payer Claims Database 11.A • Homer Warner Center for 7.E.6 Informatics Research 7.E.7 1. THE INTERMOUNTAIN WEST REGION 1.A. The Intermountain West The University of Utah (U of Utah) healthcare system (U Health) is the only academic health center serving Utah, Wyoming, Idaho, and Montana. Utah is located in the Intermountain West, comprised of Utah, Nevada, Montana, Wyoming, New Mexico, Idaho, Arizona, and Colorado. The Intermountain West collectively encompasses more than 10% of the continental United States. Importantly, this region contains not only urban and suburban, but also large rural and immense frontier areas. The population of the region, over 22 million in the 2010 census, is steadily growing (Figure 1). 1.B. Utah According to the US Census Bureau, the State of Utah is the fastest growing state in the U.S. with a current population estimate of 3 million residents. This growth is attributed to a higher than the national average birth rate but also net in-migration from other states and countries. This population is unique, with lower median age (30.7% under 18, average age 29.2), larger families (3.12 persons per household compared to 2.63) Importantly, many of Utah’s families are multigenerational, and have a long history in the state and surrounding region. Utah is a racially and ethnically diverse state. Utah’s minority share exceeds 20% and is comparable to national averages, with large Hispanic/Latino communities, and significant Native Hawaiian/Pacific Islander, Asian, Black/African American, and multiethnic communities. Utah is home to seven Native American tribes/nations: Shoshone, Goshute, Confederated Tribes of the Goshute Reservation, Paiute, Navajo (Dine), White Mesa, and Ute. Of note, amongst Pacific Islander communities, approximately one of four people of Tongan descent living in the Figure 1. Population of the Intermountain West. The eight states United States live in Utah. Over 40 that form the Intermountain West (highlighted in red) have a collective languages other than English are population of over 22 million, and have exhibited steady population primary languages in Utah growth for over 100 years. households. Unfortunately, this diversity comes with associated healthcare disparities. Many Utah communities, particularly Native American/Alaskan Native, Black/African American, Hawaiian/Pacific Islander, and Hispanic/Latino communities are medically disadvantaged, with indicators of worse health and less insurance/ability to pay for healthcare than the White population, underscoring the importance of the Utah Center for Clinical and Translational Science’s (CCTS) efforts in the area of community engagement. In addition to being racially, ethnically, and socially diverse, Utah has a unique combination of urban, suburban, rural, and frontier communities. 90% of the state is rural, with a population of less than 100 individuals per square mile; 70% of the state is considered frontier with less than 7 individuals per square mile 1.C. Salt Lake City Salt Lake City is home to the main offices and flagship hospitals of all of the Utah CCTS partners. Salt Lake City is located in Salt Lake County, a County that is home to a diverse population of approximately 1 million individuals (2015 estimate). In Salt Lake City, 24% of the population identifies as Hispanic/Latino (of any race), compared to the national average of 16.3%; 2.3% identify as Native Hawaiian/Pacific Islander and 1.2% identify as American Indian/Alaskan Native compared to the national average of 0.9%. The non-white distribution of Asian, Black/African American, and Native Hawaiian/Pacific Islander populations are Figure 2. Racial demographics of Salt Lake County & City. The racial diversity of Salt Lake Count & Salt Lake City are comparable to national averages. US (White excluded) SLC (White excluded) United States Salt Lake County Salt Lake City 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% White Some Other Race Asian Two or More Races Black or African American Native Hawaiian and Other Pacific Islander American Indian and Alaska Native represented equally, while the national average of non-whites is predominantly African American (Figure 2). 2. UNIVERSITY OF UTAH (U OF UTAH) AND UNIVERSITY OF UTAH HEALTH (U HEALTH) Nearly 3,000 people of Tongan descent live in Salt Lake City alone. University of Utah (U of Utah) The U of Utah is the state's flagship university, offering more than 100 undergraduate majors and 92 graduate degree programs (Letter of Support (LOS) Dr. Pershing). The Carnegie Classification of Institutions of Higher Education designates the university with its highest ranking. The 17 colleges and schools incorporate nearly 100 departments. These include graduate studies at the School of Medicine (Utah's only medical school), the S.J. Quinney College of Law and Colleges of Engineering, Health, Nursing, Pharmacy, Social and Behavioral Science, and Social Work.
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