Arium® Pro Ultrapure Water Systems Application-Orientated and Flexible to Meet the Highest Demands

arium® pro Ultrapure Water Systems Application-Orientated and Flexible to Meet the Highest Demands

Modular – selection of five systems specially for your application

Flexible – perfect fit to every laboratory environment

Easy to use – glass touch display with intuitive menu Water Purification in Laboratories navigation

arium® pro ultrapure water systems

Description Modular The arium® pro series offers a flexible and The selection of five systems contains module modular system which, compared to conven- components specially tailored to your appli- tional devices, demonstrates excellent cost cation. arium® pro supplies the desired level efficiency. of ultrapure water quality for any critical and standard applications. All systems meet and exceed the ASTM Type 1 water quality standards and ensure the best Flexible reproducible results in their class. Up to The space-saving installation of the device 2 liter of consistently high-quality ultrapure on, under, or above your workstation water with a conductivity of 0.055 µS/cm integrates it perfectly into any laboratory. (0 18.2 MO + cm) can be dispensed each The display-dispense unit can be flexible minute. The ultrapure water is virtually positioned. microorganism-free when a Sartopore® 2 150 end filter is used. Display with touch-function Even the opening of the dispensing valve The patented Sartorius technology, SD card can be controlled by the unique display. slot, long service life, and low maintenance Simply navigate intuitively in the easy-to- requirement distinguish the arium® pro use and clear menu navigation by lightly systems as easy-to-use, efficient and reliable touching the display – even with gloves. Type 1 ultrapure water systems.

Applications – HPLC, GC-MS – Biological applications e.g. Cell Culture – Standard Applications such as preparation of solutions, media and reagents Technical Specifications

Technical Specifications Feed Water Quality Water purified by reverse osmosis, Dimensions: 35.0 + 49.2 + 45,1 cm 1 Width + height + depth distillation or Deionisation. Empty weight 17 – 19 kg, depending on system type Input pressure 0 – 6.9 bar, recomm. > 2 bar Operating weight 27 – 29 kg, depending Temperature 2 – 30 °C on system type Specific < 100 μS/cm compensated Power supply 100 – 240 VAC conductivity to 25 °C (± 10%); 50 – 60 Hz, TOC content < 50 ppb 130 VA (max.) Turbidity < 1 NTU Operating 2 °C – 35 °C at max. pH value 4 – 10 temperature 80% rel. humidity Storage 5 °C – 45 °C at max. temperature 80% rel. humidity 1 To operate arium® pro with non-treated drinking water the Universal Kit could be used in most cases. Data output SD card slot2, In order to verify the specifications of your feed RS-232 interface water, please contact the Sartorius Application Support. 2 ® Not applicable for arium pro

arium® pro DI and arium® pro

Description Product water quality ® The arium pro DI is a highly efficient water Water purification Adsorption by Standard Applications treatment system and the ultrapure water methods spherical activated – AAS, ICP-MS quality exceeds the ASTM Type 1 quality carbon, deionization, standard. – Ion chromatography optional final particle and sterile filtration – Preparation of reagents Water is purified by a three-stage process. – Photometry In the first two stages, both organic and Type of water ASTM Type 1 inorganic components are removed reliably ultrapure water from the feed water by using the specially Output 120 l/h developed Elemental Kit cartridges. The Water dispensing 0.1 – 2 l/ min. adjustable third purification stage is performed using flow rate a Sartopore® final filter, which is connected Volume controlled 2 l/min in 100 ml, 1 l or directly at the point of use and removes 4 particles and bacteria. output 5 l steps, depending on total dispense between The arium® pro offers an even more 0,1 l and 60 l affordable alternative. Reduced to the Volume accuracy5 3 % in the range of essential features, it produces ultrapure 0.25 l and 60 l water – without any compromises. Conductivity1 0.055 µS/cm compensated to 25 °C Resistivity1 18.2 MO + cm compensated to 25 °C TOC content3 < 5 ppb Microorganism < 1 CFU/1,000 ml content2 Particle content2 < 1/ml

arium® pro DI and pro systems for producing ASTM Type 1 ultrapure water Equipment supplied: 1 arium® pro and Connection Set

VWR Cat. No. Sartorius Description Cat. No. 89510-564 H2Opro-DI-T arium® pro DI Bench-Top system in a compact design for every laboratory workstation 89510-566 H2Opro-DI-B arium® pro DI space saving Wall-Mounted system with integrated wall bracket 89510-568 H2Opro-DI-D arium® pro DI Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit 89510-558 H2Obasic-T arium® pro Bench-Top system in a compact design for every laboratory workstation 89510-556 H2Obasic-B arium® pro space saving Wall-Mounted system with integrated wall bracket

1 Measured value output is adjustable to 25 °C compensated or non-compensated 2 When using a Sartopore® 2 150 end filter 3 Feed water < 50 ppb TOC content 4 At 2 bar pressure, depending on the connected accessories and end filter 5 Under constant operating conditions

arium® pro UV

Description Product water quality ® ® Like arium pro DI, the arium pro UV features Water purification Adsorption by spherical three-stage purification technology. Yet it methods activated carbon, de- Chemical-Analytical Applications additionally uses photooxidation to remove ionization, UV-irradiation, – HPLC organic components. optional final particle and sterile filtration – GC-MS, AAS, ICP-MS With two different wavelengths, the horizon- – Ion chromatography tally positioned UV lamp (185 | 254 mm) pre- Type of water ASTM Type 1 ultrapure water – TOC-Analysis vents microbial growth and reliably reduces ≤ – Photometry organic compounds to a TOC value of 2 ppb. Output 120 l/h Water dispensing 0.1 – 2 l/ min. adjustable Perfectly matched to support photooxidation flow rate technology, the Analytical Kit cartridges Volume controlled 2 l/min in 100 ml, 1 l or optimize water purification and specifically 4 remove inorganic and organic substances. output 5 l steps, depending on total dispense between The current TOC values are continuously 0,1 l and 60 l measured by the optionally integrated TOC Volume accuracy5 3 % in the range of monitor and shown on the display. 0.25 l and 60 l Conductivity1 0.055 µS/cm compensated to 25 °C Resistivity1 18.2 MO + cm compensated to 25 °C TOC content3 ≤ 2 ppb Microorganism < 1 CFU/1.000 ml content2 Particle content2 < 1/ml

arium® pro UV systems for producing ASTM Type 1 ultrapure water Equipment supplied: 1 arium® pro with UV Lamp (185 | 254 nm) and Connection Set

VWR Cat. No. Sartorius Cat. No. Description 89510-576 H2Opro-UV-T arium® pro UV Bench-Top system in a compact design for every laboratory workstation, incl. UV Lamp 89510-572 H2Opro-UV-B arium® pro UV space saving Wall-Mounted system with integrated wall bracket and incl. UV Lamp 89510-574 H2Opro-UV-D arium® pro UV Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit and incl. UV Lamp 89510-588 H2Opro-UV-T-TOC arium® pro UV Bench-Top system in a compact design for every laboratory workstation, incl. UV Lamp and TOC Monitor 89510-584 H2Opro-UV-B-TOC arium® pro UV space saving Wall-Mounted system with integrated wall bracket, incl. UV Lamp and TOC Monitor 89510-586 H2Opro-UV-D-TOC arium® pro UV Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit, incl. UV Lamp and TOC Monitor

arium® pro UF

Description Product water quality In addition to featuring highly efficient puri- Water purification Adsorption by spherical fication components, such as active carbon methods activated carbon, de- Biological Applications and highly effective ion exchange resin, the ® ionization, ultrafiltration, – AAS, ICP-MS arium pro UF ultrapure water system addi- optional final particle tionally includes a hollow-fiber ultrafilter. and sterile filtration – Ion chromatography This ultrafilter uses crossflow technology to – Electrophoresis reliably remove endotoxins, microorganisms Type of water ASTM Type 1 ultrapure water – Endotoxin-Analysis and particles, as well as DNases and RNases – Immunocytochemistry from ultrapure water. As a result, this filter Output 120 l/h makes the arium® pro UF ideal for use in – Nutrient media for cell culture Water dispensing 0.1 – 1.7 l/min. adjustable cell cultivation, electrophoresis, and many flow rate – Production of monoclonal antibodies other related applications. Volume controlled 1.7 l/min in 100 ml, 1 l or – Photometry 4 Supported by the top-down flow technology output 5 l steps, depending on incorporated into Biological Kit cartridges, total dispense between the system produces ASTM Type 1 ultrapure 0,1 l and 60 l water of the highest quality. Volume accuracy5 3 % in the range of 0.25 l and 60 l Conductivity1 0.055 µS/cm compensated to 25 °C Resistivity1 18.2 MO + cm compensated to 25 °C TOC content3 < 5 ppb Microorganism < 1 CFU/1,000 ml content2 Particle content2 < 1/ml Endotoxin < 0.001 EU/ml RNase content < 0.004 ng/ml DNase content < 0.024 pg/µl

arium® pro UF systems for producing ASTM Type 1 ultrapure water Equipment supplied: 1 arium® pro with Ultrafilter and Connection Set

VWR Cat. No. Sartorius Cat. No. Description 89510-570 H2Opro-UF-T arium® pro UF Bench-Top system in a compact design for every laboratory workstation, incl. Ultrafilter 89510-566 H2Opro-UF-B arium® pro UF space saving Wall-Mounted system with integrated wall bracket and incl. Ultrafilter 89510-568 H2Opro-UF-D arium® pro UF Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit and incl. Ultrafilter

Description Product water quality This high-end unit delivers ultrapure water Water purification Adsorption by spherical of the highest quality and combines the ® methods activated carbon, de- Chemical-Analytical, Biological, purification technology of the arium pro UF ionization, ultrafiltration, and Standard Applications and pro UV units all into one system. UV irradiation, optional – HPLC, GC-MS, AAS, ICP-MS, IC final particle and sterile – PCR The integrated, horizontal UV lamp (185 | filtration 254 mm), together with a hollow-fiber ultra- – Electrophoresis filter, not only prevents microbial growth Type of water ASTM Type 1 – Endotoxin-Analysis and reduces the TOC content to a minimum ultrapure water – Immunocytochemistry of ≤ 2 ppb, but also additionally removes Output 120 l/h – Nutrient media for cell culture endotoxins, microorganisms and particles, Water dispensing 0.1 – 1.7 l/min. adjustable – Production of monoclonal antibodies as well as DNases and RNases. As a result, it flow rate is the perfect solution for a large number of – Photometry critical applications in the laboratory. Volume controlled 1.7 l/min in 100 ml, 1 l or output4 5 l steps, depending on Current TOC values are continuously total dispense between measured with the highest accuracy by 0,1 l and 60 l the optionally integrated TOC monitor Volume accuracy5 3 % in the range of and displayed on the screen. 0.25 l and 60 l Conductivity1 0.055 µS/cm compensated to 25 °C Resistivity1 18.2 MO + cm compensated to 25 °C TOC content3 ≤ 2 ppb Microorganism < 1 CFU/1,000 ml content2 Particle content2 < 1/ml Endotoxin < 0.001 EU/ml RNase content < 0.004 ng/ml DNase content < 0.024 pg/µl

arium® pro VF systems for producing ASTM Type 1 ultrapure water Equipment supplied: 1 arium® pro with UV lamp (185 | 254 nm), Ultrafilter and Connection Set

VWR Cat. No. Sartorius Cat. No. Description 89510-582 H2Opro-VF-T arium® pro VF Bench-Top system in a compact design for every laboratory workstation, incl. UV Lamp and Ultrafilter 89510-578 H2Opro-VF-B arium® pro VF space saving Wall-Mounted system with integrated wall bracket, incl. UV Lamp and Ultrafilter 89510-580 H2Opro-VF-D arium® pro VF Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit, incl. UV Lamp and Ultrafilter 89510-594 H2Opro-VF-T-TOC arium® pro VF Bench-Top system in a compact design for every laboratory workstation, incl. UV Lamp, Ultrafilter and TOC Monitor 89510-590 H2Opro-VF-B-TOC arium® pro VF space saving Wall-Mounted system with integrated wall bracket, incl. UV Lamp, Ultrafilter and TOC Monitor 89510-592 H2Opro-VF-D-TOC arium® pro VF Built-In system, space saving in every laboratory cabinet, with integrated wall bracket for display-dispense unit, incl. UV Lamp, Ultrafilter and TOC Monitor

Description Technical Specifications ® The arium dispense gun is an ergonomic, Materials easy-to-handle dispensing unit that is excellently suited for dispensing ultrapure Stand Aluminum water. (gray anodized) Dispense gun Plastic, white finish Depending on the working environment, you Tubing PVDF can save space by mounting the dispense gun on the wall or on a stand that is height- Dimensions without tubing [W + H + D] adjustable up to 70 cm. Dispense gun with stand 18.5 + 59.5 + 51.0 cm Dispense gun with wall 9.0 + 10.0 + 28.5 cm Moreover, the stand lets you work in a mounting bracket relaxed position and allows optimal adjust- ment to different sized sampling vessels. Weight without tubing – Extended working area of 3.7 m Thanks to the extended tubing, the work Dispense gun with stand 5.60 kg area has an expanded radius to up to 2.5 m – Available with a height-adjustable Dispense gun with wall 0.46 kg away from the arium® unit and another stand or wall mounting bracket mounting bracket 1.2 m to the stand. – Ergonomic design Intended Use – Easy-to-use It is also easy to install a sterile-grade ® ® arium comfort I and comfort II – Sterile-grade filters connectable filter (Sartopore 2 150 capsule) with arium® pro DI, pro UF, pro UV and pro VF 0.2 μm pore size for guaranteed sterile arium® 611 and particulate-free water dispensing.

VWR Cat. No. Sartorius Cat. No. Description 89510-734 H2Opro-AMDG1 arium® Dispense Gun inclusive height-adjustable Stand, qty. 1 unit 89510-736 H2Opro-AMDG2 arium® Dispense Gun inclusive wall mounting kit, qty. 1 unit arium® Water Guard Early Detection of Leakages Protects the Laboratory

Description Technical Specifications Only the early detection of water leakages Sensor Dimensions provides optimal protection against water damage in the laboratory. Leakages are regis- Diameter 5 cm tered by the highly sensitive optical sensor. Height 2.5 cm Cable length 2 m In contrast to conventional sensors, this sensor functions independently of conductivity Tubing Connections measurement values as these are so low in the Input a“ plug connection ultrapure water area that the activation of the guard is not guaranteed. Once a leakage is Output a“ plug connection detected the water guard automatically locks Power supply 100 – 240 VAC 50 – 60 Hz the feed water inlet line. An acoustic warning is triggered immediately and the system status can be constantly controlled using the Intended Use – Highly sensitive optical sensor integrated LED display. The sensitive, optical System type: ® – Audiovisual alarm signals sensors and high-grade materials mean arium comfort I and comfort II that the arium® water guard is perfect for arium® pro, pro DI, pro UF, pro UV and pro VF – Automatic water-stop in case of leakage all ultrapure and pure water systems. arium® advance RO and EDI – High-grade material, non-corrosive arium® 611, 612 and 613 – Easy to install – Integrated wall mounting bracket for VWR Cat. No. Sartorius Cat. No. Description magnetic valve 89510-708 610AWG1 arium® Water Guard, qty. 1 unit

arium® Foot Switch More Convenient Pure Water Dispensing

Description Technical Specifications Easy-to-connect foot switch for starting Material Nylon, glass fiber and stopping the water dispensing. reinforced The rugged foot switch frees up both hands for other tasks, such as changing vessels, and Dimensions 14.0 + + + minimizes the risk of contamination in the [W H D] 4.5 (max.) + 10.6 cm cleanroom. Cable length 2 m Power supply 100 – 240 VAC 50 – 60 Hz Connector Phoenix plug, 2-pin

Intended Use arium® comfort I and comfort II arium® pro DI, pro UF, pro UV and pro VF

– Water dispensing at a press of the foot – Ideally suited for clean rooms, minimize the risk of contamination – Comfortable fatigue-free switching thanks to low height VWR Cat. No. Sartorius Cat. No. Description 89510-718 H2O-AFS1 arium® Foot Switch, qty. 1 unit arium® Level Sensor Practically Separate Tank Filling

Description Technical Specifications The level sensor makes it easy to connect an Length Level Sensor 88 mm external water storage tank and subsequently fill a tank with ultrapure water. Diameter Connection 2.03 cm (max.) Bore 1.65 cm Cable length 3 m

Intended Use arium® pro DI, pro UF, pro UV and pro VF

VWR Cat. No. Sartorius Cat. No. Description 89510-706 H2O-ALS1 arium® Level Sensor, qty. 1 unit – Flexible water transport to anywhere – Can fill every tank system

arium® Printer GMP Data Logging Make Easy

Description Technical Specifications Current measurements can be output to Dimensions 21.5 + 7.8 + 15.5 cm the printer via an RS-232 interface to support [W + H + D] qualification and documentation tasks. Intended Use arium® comfort I and comfort II arium® pro DI, pro UF, pro UV and pro VF arium® 611, 612 and 613

VWR Cat. No. Sartorius Cat. No. Description 89510-710 611APR1 arium® Printer, qty. 1 unit

– Acquisition and documentation of current measurement data arium® Sterile-grade Filter Sterile and Particle-free Water Dispensing

Description Technical Specifications ® ® The arium sterile-grade filter (Sartopore 2 Materials 150) is a sterile, ready-to-use membrane filter Membranes Asym. capsule for the most Polyethersulfone stringent requirements. Sartopore® 2 150 membrane filter capsules contain a hydro Filling bell Polycarbonate philic, heterogeneous polyethersulfone Other plastics Polypropylene double membrane. It enables an excellent Pore size 0.45 μm + 0.2 μm service life and output. The capsule is Filtration area 0.015 m2 attached, by a quick connector, at the final Input and output 1/4” plug connection position and reliably removes all particles. Sterilization Autoclaving at 134°C, A hydrophobic PTFE membrane at the farthest (max. 3 cycles) 1 bar, 30 min. point „upstream“ allows for easy and clean Max. diffusion 1 ml/min @ 2.5 bar venting of the capsule. Min. bubble point 3.2 bar – Excellent service lifetime and flow rate All pleated Sartopore® 2 membrane filter Intended Use – Integrity tested units are validated as sterile filters for bio- pharmaceutical applications according to On Dispense Guns and Display-Dispense – Validated acc. to HIMA and ASTM F-838-05 Unit for system type: the HIMA and ASTM F-838-05 guidelines ® – Meets WFI quality standards acc. to USP (documentation available). During the arium comfort I and comfort II incl. USP plastic class VI test arium® pro, pro DI, pro UF, pro UV and pro VF manufacturing process, every unit is tested ® – Manufacture acc. to DIN ISO 9001 for integrity in order to meet the highest arium 611 arium® bagtank Dispense Gun – Easy to install quality standards and safety regulations. arium® Dispense Gun – Automatic venting – Certified quality VWR Cat. No. Sartorius Cat. No. Description 89510-670 5441307H4--CE--B arium® Sterile-grade Filter (Sartopore® 2 150 capsules), 0.2 µm pore size, qty. 5 units arium® UV Lamp (185 | 254 nm) Ultrapure Water, Free of TOC

Description Technical Specifications The horizontally arranged UV lamp delivers Material quartz glass especially reliable results. Unlike vertical units, the temperature gradient is less pro- TOC-content product water* < 2 ppb nounced and does not affect the activity of UV waves. The two different wavelengths reliably removes organic substances (TOC or Intended Use total organic carbon), effectively preventing arium® comfort I and comfort II microbiological growth. Organic compounds arium® pro UV and pro VF oxidize at 185 nm, whereas 254 nm prevents arium® 611 UV and VF microbiological growth. * Feed water < 50 ppb TOC content

– Horizontal installation, optimize temperature gradient VWR Cat. No. Sartorius Cat. No. Description – Effectively destroys organic compounds 89510-712 611CEL1 arium® UV Lamp (185 | 254 nm), qty. 1 – Reduces microbiological growth unit – Easy replacement arium® Ultrafilter Ultrapure Water, Free of Endotoxines, DNases and RNases

Description Technical Specifications The hollow-fiber ultrafilter utilizes crossflow Materials technology to reliably remove bacterial endotoxins, microorganisms and particulates, Membrane polysulfone as well as DNases and RNases from the Composites polyurethane (PUR) ultrapure water. Housings, Caps polycarbonate (PC) The filters have been developed and manu- Plugs polypropylene (PP) factured according to DIN EN ISO 9001 | Effective membrane 2.1 m2 DIN EN 46 001 certified quality assurance area system that meets the requirements of the FDA’s Quality System Regulation 21 CFR Max. pressure 3 bar at room Part 820. During the manufacturing process, temperature every unit is integrity tested to meet the Sanitization 200 ppm sodium highest quality standards and safety regula- hypochlorite, 45 min, tions. max. 1+/week Filling volume – High flow rates Lumen 152 ml – Integrity tested Filtrate area 306 ml – Long service lives Retention of bacteria and endotoxins – Certified quality Brev. diminuta LRV 7-10 E. coli O55:B5 LRV > 3.5 Endotoxin Natural Endotoxins LRV > 3.0 Dimensions fibers Inner diameter 215 μm Wall thickness 50 μm Molecular Weight 5.000 ( = 5 kD) Cut Off (MWCO)

Intended Use arium® pro VF and pro UF arium® 611 VF and UF

VWR Cat. No. Sartorius Cat. No. Description 89510-674 611CDU5 arium® Ultrafilter, qty. 1 unit www.vwr.com 1-800-932-5000 VWR International Contact Details 0114 Lit.No. 19825W

Technical specifications subject to change without notice. Printed in Germany. Printed on bleached, chlorine-free paper. | W Publication No.: SLG2049-e13013 · Order No.: 85032-542-54 · Ver. 01 | 2013