Drug-Target Pairs: R2 1

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Drug-target pairs: R2 1

2578 Target 3170 DB04124 2586 Target 4909 DB03014 2594 Target 2745 DB04281

EFTU2 THET8 Aurodox P72322 RHORU Heme PYRD RAT 2-[4-(4-Chlo rophen..

Elongation factor CooA protein Dihydroorotate Tu-B dehydrogenase, mitochondrial precursor

2579 Target 4911 DB03014 2587 Target 4941 DB03014 2595 Target 424 DB01117

Q43758 SOYBN Heme CATB PSESY Heme PYRD HUMAN Atovaquone

Approved Ascorbate peroxi- Catalase Dihydroorotate dase dehydrogenase, mitochondrial precursor

2580 Target 2250 DB02920 2588 Target 4937 DB03014 2596 Target 424 DB04583

CCPR YEAST Zn(Ii)-(20-O Q9F3S9 RHOMR Heme PYRD HUMAN 5-(AMINOCARB xo-Pro.. ONYL)-..

Cytochrome Cytochrome Dihydroorotate c peroxidase, oxidase subunit II dehydrogenase, mitochondrial mitochondrial precursor precursor

2581 Target 2250 DB03418 2589 Target 2391 DB02188 2597 Target 4912 DB03014

CCPR YEAST Diacetyldeut HEMH BACSU N-Methylmeso FRD2 SHEFN Heme erohem.. porphy..

Cytochrome Ferrochelatase Fumarate reduc- c peroxidase, tase flavoprotein mitochondrial subunit precursor

2582 Target 2250 DB02577 2590 Target 2391 DB01911 2598 Target 3673 DB03014

CCPR YEAST Mesoheme HEMH BACSU N-Methylmeso FRDA SHEFR Heme porphy..

Cytochrome Ferrochelatase Fumarate reduc- c peroxidase, tase flavoprotein mitochondrial subunit precursor

2583 Target 2250 DB03014 2591 Target 5000 DB03014 2599 Target 2709 DB03014

CCPR YEAST Heme Q9RGD9 NEIME Heme FRDA SHEON Heme

Cytochrome HemO Fumarate reduc- c peroxidase, tase flavoprotein mitochondrial subunit precursor precursor

2584 Target 2250 DB04384 2592 Target 4379 DB02914 2600 Target 2617 DB03014

CCPR YEAST Fe-Mesopone Q26490 SPOFR (6e)-6-[(2e, NOSO BACSU Heme 4e,6e)..

Cytochrome Retinol dehy- Nitric oxide syn- c peroxidase, dratase thase oxygenase mitochondrial precursor

2585 Target 3102 DB03014 2593 Target 4379 DB02699 2601 Target 2701 DB03014

HMP RALEH Heme Q26490 SPOFR 4-Oxoretinol NOSO STAAW Heme

Flavohemoprotein Retinol dehy- Nitric oxide syn- dratase thase oxygenase Drug-target pairs: R2 2

2602 Target 4988 DB03014 2610 Target 3411 DB03014 2618 Target 358 DB03014

SUOX HUMAN Heme CP121 MYCTU Heme CBS HUMAN Heme

Sulfite oxidase, Cytochrome P450 Cystathionine mitochondrial 121 beta-synthase

2603 Target 4929 DB03014 2611 Target 4960 DB03014 2619 Target 3202 DB03903

SUOX CHICK Heme Q9L142 STRCO Heme ACTS RAT Tmr

Sulfite oxidase Putative cy- Actin, alpha skele- tochrome tal muscle P450-family protein

2604 Target 4983 DB03014 2612 Target 2915 DB03014 2620 Target 5724 DB04783

Q8LNY5 TOBAC Heme FIXL BRAJA Heme ACTS RABIT Sphinxolide B..

Stromal ascorbate Sensor protein Actin, alpha skele- peroxidase fixL tal muscle

2605 Target 4608 DB03014 2613 Target 4944 DB03014 2621 Target 5724 DB04774

Q9FCA6 STRCO Heme FIXL RHIME Heme ACTS RABIT Reidispongio lide A..

Putative cy- Sensor protein Actin, alpha skele- tochrome P450 fixL tal muscle

2606 Target 2972 DB03014 2614 Target 4926 DB03014 2622 Target 5724 DB04775

CPXJ SACER Heme HEMAT BACSU Heme ACTS RABIT Reidispongio lide C..

6- Heme-based aero- Actin, alpha skele- deoxyerythronolide tactic transducer tal muscle B hydroxylase hemAT

2607 Target 4963 DB03014 2615 Target 2159 DB00266 2623 Target 5724 DB04629

Q9KZR7 STRCO Heme QOR HUMAN Dicumarol ACTS RABIT Aplyronine A

Approved Putative cy- Quinone oxidore- Actin, alpha skele- tochrome P450 ductase tal muscle

2608 Target 4999 DB03014 2616 Target 358 DB00114 2624 Target 3202 DB02621

C5B3 AMYOR Heme CBS HUMAN Pyridoxal Ph ACTS RAT 4-(17-Hydrox osphat.. y-5,12..

Approved Cytochrome P450 Cystathionine Actin, alpha skele- 165B3 beta-synthase tal muscle

2609 Target 4764 DB03014 2617 Target 358 DB00165 2625 Target 2328 DB03759

C5C4 AMYOR Heme CBS HUMAN Pyridoxine GRIA2 RAT Dnqx

Approved Cytochrome P450 Cystathionine Glutamate recep- 165C4 beta-synthase tor 2 precursor Drug-target pairs: R2 3

2626 Target 2328 DB04152 2634 Target 3722 DB02033 2642 Target 762 DB00270

GRIA2 RAT 2-Amino-3-(3 POL HV1B1 N-(3-Cyclopr CAC2D HUMAN Isradipine -Hydro.. opyl(5..

Approved Glutamate recep- Gag-Pol polypro- Voltage- tor 2 precursor tein dependent calcium channel subunit alpha-2/delta-1

2627 Target 4762 DB04297 2635 Target 2427 DB04220 2643 Target 4148 DB06287

O67135 AQUAE 7-[4-(Dimeth FHUA ECOLI Rifamycin Cg FRAP HUMAN Temsirolimus ylamin.. p 4832..

Approved Acetoin utiliza- Ferrichrome-iron FKBP12- tion protein receptor precursor rapamycin complex- associated protein

2628 Target 2921 DB04297 2636 Target 3279 DB02424 2644 Target 4148 DB01590

HDAC8 HUMAN 7-[4-(Dimeth HSP82 YEAST Geldanamycin FRAP HUMAN Everolimus ylamin..

Approved Histone deacety- ATP-dependent FKBP12- lase 8 molecular rapamycin chaperone HSP82 complex- associated protein

2629 Target 339 DB01188 2637 Target 1939 DB02424 2645 Target 226 DB01406

LOX15 HUMAN Ciclopirox HS90A HUMAN Geldanamycin GNRHR HUMAN Danazol

Approved Approved Arachidonate 15- Heat shock pro- Gonadotropin- lipoxygenase tein HSP 90-alpha releasing hormone receptor

2630 Target 20 DB01188 2638 Target 2614 DB03080 2646 Target 2818 DB02124

PGH1 HUMAN Ciclopirox HS90A PIG 17-Dmag PHZF PSEFL (2s,3s)-Tran s-2,3-..

Approved Prostaglandin Heat shock pro- Phenazine biosyn- G/H synthase 1 tein HSP 90-alpha thesis protein precursor phzF

2631 Target 290 DB01188 2639 Target 3276 DB02852 2647 Target 2787 DB02133

PGH2 HUMAN Ciclopirox GRIK2 RAT Domoic Acid CB22 PEA Chlorophyll A..

Approved Prostaglandin Glutamate recep- Chlorophyll a-b G/H synthase 2 tor, ionotropic binding protein precursor kainate 2 AB80, chloroplast precursor precursor

2632 Target 2404 DB04769 2640 Target 136 DB01406 2648 Target 127 DB02133

PK3CG HUMAN 5-QUINOXALIN ESR1 HUMAN Danazol CB2A SPIOL Chlorophyll -6-YLM.. A..

Approved Phosphatidylinositol- Estrogen receptor Chlorophyll a-b 4,5-bisphosphate binding protein, 3-kinase catalytic chloroplast subunit gamma precursor isoform

2633 Target 3307 DB03825 2641 Target 478 DB00270 2649 Target 127 DB00137

ACRB ECOLI Rhodamine 6g CAC1C HUMAN Isradipine CB2A SPIOL Xanthophyll

Approved Approved Acriflavine resis- Voltage- Chlorophyll a-b tance protein B dependent binding protein, L-type calcium chloroplast channel subunit precursor alpha-1C Drug-target pairs: R2 4

2650 Target 127 DB03460 2658 Target 4940 DB03014 2666 Target 3229 DB03014

CB2A SPIOL Violaxanthin CATA YEAST Heme CAT1 NEUCR Heme

Chlorophyll a-b Peroxisomal cata- Catalase-1 binding protein, lase A chloroplast precursor

2651 Target 2882 DB02864 2659 Target 4919 DB03014 2667 Target 518 DB03014

ICYA MANSE Biliverdin I CATA BOVIN Heme CATA MYCTU Heme x Gamm..

Insecticyanin A Catalase Peroxidase/catalase form T

2652 Target 4982 DB03014 2660 Target 2230 DB03014 2668 Target 4920 DB03014

HO2 SYNY3 Heme CATA HUMAN Heme Q939D2 BURPS Heme

Heme oxygenase 2 Catalase Peroxidase/catalase

2653 Target 3391 DB03014 2661 Target 3625 DB03014 2669 Target 4957 DB03014

HO1 SYNY3 Heme CATA PROMI Heme CATA HALMA Heme

Heme oxygenase 1 Catalase Peroxidase/catalase

2654 Target 4989 DB03014 2662 Target 4539 DB03014 2670 Target 2732 DB03014

CCPR NITEU Heme CATA HELPY Heme HMOX1 RAT Heme

Cytochrome c551 Catalase Heme oxygenase 1 peroxidase

2655 Target 4992 DB03014 2663 Target 2763 DB03014 2671 Target 2732 DB02073

P83787 MARHY Heme CDH PHACH Heme HMOX1 RAT Biliverdine Ix Alp..

Cytochrome c per- Cellobiose de- Heme oxygenase 1 oxidase hydrogenase precursor

2656 Target 4952 DB03014 2664 Target 4973 DB03014 2672 Target 810 DB02073

Q834P5 ENTFA Heme AOSL PLEHO Heme HMOX1 HUMAN Biliverdine Ix Alp..

Catalase/peroxidase Allene oxide Heme oxygenase 1 synthase- lipoxygenase protein

2657 Target 3249 DB03014 2665 Target 3093 DB03014 2673 Target 810 DB03906

CATA MICLU Heme CATE ECOLI Heme HMOX1 HUMAN 2-Phenylheme

Catalase Catalase HPII Heme oxygenase 1 Drug-target pairs: R2 5

2674 Target 810 DB02468 2682 Target 756 DB00783 2690 Target 2687 DB02199

HMOX1 HUMAN 12-Phenylhem SHBG HUMAN Estradiol NP4 RHOPR 1,3-Dedimeth e.. yl-1,3..

Approved Heme oxygenase 1 Sex hormone- Nitrophorin-4 pre- binding globulin cursor precursor

2675 Target 810 DB03014 2683 Target 756 DB01406 2691 Target 2603 DB02863

HMOX1 HUMAN Heme SHBG HUMAN Danazol BLA2 BACCE Alpha Chloro phyll ..

Approved Heme oxygenase 1 Sex hormone- Beta-lactamase II binding globulin precursor precursor

2676 Target 4976 DB03014 2684 Target 345 DB00162 2692 Target 4978 DB03014

CYF PHOLA Heme RETBP HUMAN Vitamin A O76745 CIMLE Heme

Approved Apocytochrome f Plasma retinol- Salivary ni- binding protein trophorin precursor

2677 Target 4932 DB03014 2685 Target 2594 DB01770 2693 Target 3374 DB03014

CYF CHLRE Heme RETBP BOVIN All-Trans Ax CPXW SULSO Heme eropht..

Apocytochrome f Plasma retinol- Cytochrome P450 binding protein 119

2678 Target 2661 DB03001 2686 Target 2594 DB03922 2694 Target 4969 DB03014

PCP1 AMPCA Peridinin RETBP BOVIN N-(4-Hydroxy HMP ECOLI Heme phenyl..

Peridinin- Plasma retinol- Flavohemoprotein chlorophyll binding protein a-binding protein 1, chloroplast precursor

2679 Target 2661 DB02133 2687 Target 2594 DB03917 2695 Target 4972 DB03014

PCP1 AMPCA Chlorophyll RETBP BOVIN N-Ethyl Reti Q8VQF6 CITBR Heme A.. namide..

Peridinin- Plasma retinol- P450cin chlorophyll binding protein a-binding protein 1, chloroplast precursor

2680 Target 756 DB00648 2688 Target 4962 DB03014 2696 Target 4289 DB03014

SHBG HUMAN Mitotane NP2 RHOPR Heme Q746J6 THET2 Heme

Approved Sex hormone- Nitrophorin-2 Cytochrome P450 binding globulin precursor

2681 Target 756 DB00655 2689 Target 2687 DB03014 2697 Target 4987 DB03014

SHBG HUMAN Estrone NP4 RHOPR Heme HEMO RABIT Heme

Approved Sex hormone- Nitrophorin-4 pre- Hemopexin binding globulin cursor precursor Drug-target pairs: R2 6

2698 Target 4970 DB03014 2706 Target 4980 DB03014 2714 Target 4903 DB03014

Q8VNU2 DESDE Heme Q55110 SYNSP Heme Q8RBX6 THETN Heme

Cytochrome c Catalase- Methyl-accepting nitrite reductase peroxidase chemotaxis catalytic subunit protein

2699 Target 4993 DB03014 2707 Target 2468 DB02110 2715 Target 4931 DB03014

HAO NITEU Heme PGH1 SHEEP Protoporphyr C167 POLCB Heme in Ix ..

Hydroxylamine Prostaglandin Cytochrome P450 oxidoreductase G/H synthase 1 167A1 precursor

2700 Target 4908 DB03014 2708 Target 2468 DB03014 2716 Target 3055 DB03014

DOS ECOLI Heme PGH1 SHEEP Heme PRXC CALFU Heme

Heme-regulated Prostaglandin Chloroperoxidase cyclic AMP G/H synthase 1 precursor phosphodiesterase precursor

2701 Target 2437 DB03014 2709 Target 3576 DB03014 2717 Target 3385 DB03014

NOS1 RAT Heme PGH2 MOUSE Heme NOR FUSOX Heme

Nitric-oxide Prostaglandin Cytochrome P450 synthase, brain G/H synthase 2 55A1 precursor

2702 Target 7 DB03014 2710 Target 3570 DB03014 2718 Target 4955 DB03014

NOS2A HUMAN Heme CYPC BACSU Heme O22443 SOYBN Heme

Nitric oxide syn- Cytochrome P450 Seed coat peroxi- thase, inducible 152A1 dase

2703 Target 2505 DB03014 2711 Target 3284 DB03014 2719 Target 4917 DB03014

NOS2 MOUSE Heme NIRS PARPN Heme PER53 ARATH Heme

Nitric oxide syn- Nitrite reductase Peroxidase 53 thase, inducible precursor

2704 Target 2845 DB03014 2712 Target 3284 DB03469 2720 Target 2533 DB03014

CPXB BACME Heme NIRS PARPN Heme D PER1A ARMRU Heme

Bifunctional P- Nitrite reductase Peroxidase C1A 450:NADPH-P450 precursor precursor reductase

2705 Target 4956 DB03014 2713 Target 3127 DB03469 2721 Target 2386 DB03014

Q8GR64 PSEPU Heme NIRS PSEAE Heme D PER59 ARATH Heme

Quinohemoprotein Nitrite reductase Peroxidase 59 pre- alcohol dehy- precursor cursor drogenase ADH IIB Drug-target pairs: R2 7

2722 Target 3131 DB03014 2730 Target 2112 DB00608 2738 Target 751 DB00308

LIG8 PHACH Heme TLR9 HUMAN Chloroquine KCNK6 HUMAN Ibutilide

Approved Approved Ligninase H8 pre- Toll-like receptor Potassium channel cursor 9 precursor subfamily K member 6

2723 Target 2585 DB03014 2731 Target 172 DB00908 2739 Target 835 DB01207

PER ARTRA Heme KCNK1 HUMAN Quinidine TA2R HUMAN Ridogrel

Approved Approved Peroxidase precur- Potassium channel Thromboxane A2 sor subfamily K mem- receptor ber 1

2724 Target 3373 DB03014 2732 Target 172 DB00308 2740 Target 4131 DB00905

PER COPCI Heme KCNK1 HUMAN Ibutilide PE2R3 HUMAN Bimatoprost

Approved Approved Peroxidase precur- Potassium channel Prostaglandin E2 sor subfamily K mem- receptor, EP3 sub- ber 1 type

2725 Target 4274 DB02455 2733 Target 3210 DB04794 2741 Target 516 DB01106

GUX6 HUMIN Fluoresceiny CP2B4 RABIT Bifonazole NTR2 HUMAN Levocabastin lthiou.. e..

Approved Approved Exoglucanase-6A Cytochrome P450 Neurotensin 2B4 receptor type 2

2726 Target 1971 DB00235 2734 Target 3210 DB03014 2742 Target 527 DB01088

PDE4A HUMAN Milrinone CP2B4 RABIT Heme PI2R HUMAN Iloprost

Approved Approved cAMP-specific Cytochrome P450 Prostacyclin 3’,5’-cyclic phos- 2B4 receptor phodiesterase 4A

2727 Target 541 DB01427 2735 Target 462 DB00257 2743 Target 406 DB01088

PDE4B HUMAN Amrinone KCNN4 HUMAN Clotrimazole PE2R2 HUMAN Iloprost

Approved Approved Approved cAMP-specific Intermediate Prostaglandin E2 3’,5’-cyclic phos- conductance receptor, EP2 sub- phodiesterase calcium-activated type 4B potassium channel protein 4

2728 Target 485 DB01427 2736 Target 462 DB00468 2744 Target 606 DB00169

PDE3A HUMAN Amrinone KCNN4 HUMAN Quinine CP27A HUMAN Cholecalcife rol..

Approved Approved Approved cGMP-inhibited Intermediate Cytochrome P450 3’,5’-cyclic phos- conductance 27, mitochondrial phodiesterase calcium-activated precursor A potassium channel protein 4

2729 Target 485 DB00235 2737 Target 751 DB00908 2745 Target 493 DB00153

PDE3A HUMAN Milrinone KCNK6 HUMAN Quinidine CP27B HUMAN Ergocalcifer ol..

Approved Approved Approved cGMP-inhibited Potassium channel 25- 3’,5’-cyclic phos- subfamily K mem- hydroxyvitamin phodiesterase ber 6 D-1 alpha A hydroxylase, mitochondrial precursor Drug-target pairs: R2 8

2746 Target 493 DB00146 2754 Target 627 DB00162 2762 Target 2742 DB02279

CP27B HUMAN Calcidiol RDH1 HUMAN Vitamin A CYB2 YEAST Benzoylformi c Acid..

Approved Approved 25- 11-cis retinol de- Cytochrome b2, hydroxyvitamin hydrogenase mitochondrial D-1 alpha precursor hydroxylase, mitochondrial precursor

2747 Target 493 DB00136 2755 Target 800 DB00162 2763 Target 2742 DB03014

CP27B HUMAN Calcitriol RDH12 HUMAN Vitamin A CYB2 YEAST Heme

Approved Approved 25- Retinol de- Cytochrome b2, hydroxyvitamin hydrogenase mitochondrial D-1 alpha 12 precursor hydroxylase, mitochondrial precursor

2748 Target 581 DB00169 2756 Target 4073 DB00162 2764 Target 611 DB00162

CP2R1 HUMAN Cholecalcife RDH11 HUMAN Vitamin A AL1A1 HUMAN Vitamin A rol..

Approved Approved Approved Cytochrome P450 Retinol de- Retinal de- 2R1 hydrogenase hydrogenase 11 1

2749 Target 581 DB00153 2757 Target 651 DB00162 2765 Target 611 DB00755

CP2R1 HUMAN Ergocalcifer RDH13 HUMAN Vitamin A AL1A1 HUMAN Tretinoin ol..

Approved Approved Approved Cytochrome P450 Retinol de- Retinal de- 2R1 hydrogenase hydrogenase 13 1

2750 Target 770 DB00755 2758 Target 4074 DB00162 2766 Target 569 DB00755

RAI3 HUMAN Tretinoin RDH14 HUMAN Vitamin A AL1A2 HUMAN Tretinoin

Approved Approved Approved Retinoic acid- Retinol de- Retinal de- induced protein hydrogenase hydrogenase 3 14 2

2751 Target 282 DB00162 2759 Target 4075 DB00162 2767 Target 569 DB00162

IRBP HUMAN Vitamin A Q9NYR8 HUMAN Vitamin A AL1A2 HUMAN Vitamin A

Approved Approved Approved Interphotoreceptor Photoreceptor Retinal de- retinoid-binding outer segment hydrogenase protein precursor all-trans retinol 2 dehydrogenase

2752 Target 4072 DB00162 2760 Target 719 DB00755 2768 Target 640 DB00162

RETST HUMAN Vitamin A TIG1 HUMAN Tretinoin AL1A3 HUMAN Vitamin A

Approved Approved Approved All-trans-retinol Retinoic acid re- Aldehyde de- 13,14-reductase ceptor responder hydrogenase protein 1 1A3

2753 Target 4627 DB02253 2761 Target 1097 DB00162 2769 Target 84 DB00755

P74334 SYNY3 (1r)-4-[(1e, LRAT HUMAN Vitamin A DAX1 HUMAN Tretinoin 3e,5e,..

Approved Approved Lignostilbene- Lecithin retinol Nuclear receptor alpha,beta- acyltransferase 0B1 dioxygenase Drug-target pairs: R2 9

2770 Target 1992 DB00169 2778 Target 3438 DB02998 2786 Target 4512 DB03014

VTDB HUMAN Cholecalcife ANDR RABIT Methyltrieno CP3A4 HUMAN Heme rol.. lone..

Approved Vitamin D- Androgen receptor Cytochrome P450 binding protein 3A4 precursor

2771 Target 422 DB00170 2779 Target 2974 DB02998 2787 Target 2639 DB04738

PROC HUMAN Menadione ANDR RAT Methyltrieno PP1G HUMAN Motuporin lone..

Approved Vitamin K- Androgen receptor Serine/threonine- dependent protein protein phos- C precursor phatase PP1- gamma catalytic subunit

2772 Target 3806 DB00605 2780 Target 1495 DB01117 2788 Target 2639 DB04675

PDE2A HUMAN Sulindac UQCR1 HUMAN Atovaquone PP1G HUMAN (2S,5R,8S,11 R,12S,..

Approved Approved cGMP-dependent Ubiquinol- Serine/threonine- 3’,5’-cyclic cytochrome-c protein phos- phosphodiesterase reductase complex phatase PP1- core protein 1, gamma catalytic mitochondrial subunit precursor

2773 Target 1278 DB00605 2781 Target 614 DB02998 2789 Target 2639 DB02860

EGF HUMAN Sulindac PRGR HUMAN Methyltrieno PP1G HUMAN Calyculin A lone..

Approved Pro-epidermal Progesterone Serine/threonine- growth factor receptor protein phos- precursor phatase PP1- gamma catalytic subunit

2774 Target 1245 DB00170 2782 Target 614 DB00351 2790 Target 856 DB04796

PROS HUMAN Menadione PRGR HUMAN Megestrol VDR HUMAN 19-nor-14-ep i-23-y..

Approved Approved Vitamin K- Progesterone Vitamin D3 recep- dependent protein receptor tor S precursor

2775 Target 1729 DB01009 2783 Target 614 DB00378 2791 Target 856 DB00910

O95742 HUMAN Ketoprofen PRGR HUMAN Dydrogestero VDR HUMAN Paricalcitol ne..

Approved Approved Approved Putative renal or- Progesterone Vitamin D3 recep- ganic anion trans- receptor tor porter 1

2776 Target 1792 DB01088 2784 Target 947 DB01273 2792 Target 856 DB01070

TPA HUMAN Iloprost ACHA4 HUMAN Varenicline VDR HUMAN Dihydrotachy sterol..

Approved Approved Approved Tissue-type plas- Neuronal acetyl- Vitamin D3 recep- minogen activator choline receptor tor precursor subunit alpha-4 precursor

2777 Target 146 DB00984 2785 Target 1337 DB00641 2793 Target 856 DB00153

ANDR HUMAN Nandrolone CP3A3 HUMAN Simvastatin VDR HUMAN Ergocalcifer ol..

Approved Approved Approved Androgen receptor Cytochrome P450 Vitamin D3 recep- 3A3 tor Drug-target pairs: R2 10

2794 Target 856 DB00146 2802 Target 631 DB00175 2810 Target 1783 DB00641

VDR HUMAN Calcidiol HMDH HUMAN Pravastatin ICAM1 HUMAN Simvastatin

Approved Approved Approved Vitamin D3 recep- 3-hydroxy-3- Intercellular tor methylglutaryl- adhesion molecule coenzyme A 1 precursor reductase

2795 Target 856 DB03451 2803 Target 1490 DB00175 2811 Target 2192 DB00641

VDR HUMAN 1alpha,25-Di SO1B1 HUMAN Pravastatin TNR5 HUMAN Simvastatin hydrox..

Approved Approved Vitamin D3 recep- Solute carrier Tumor necrosis tor organic anion factor receptor su- transporter family perfamily member member 1B1 5 precursor

2796 Target 856 DB00136 2804 Target 1630 DB00641 2812 Target 2163 DB00641

VDR HUMAN Calcitriol ITB2 HUMAN Simvastatin TNFC HUMAN Simvastatin

Approved Approved Approved Vitamin D3 recep- Integrin beta-2 Lymphotoxin-beta tor precursor

2797 Target 856 DB02300 2805 Target 572 DB03932 2813 Target 4093 DB00175

VDR HUMAN Calcipotriol ITAL HUMAN LFA703 ENK13 HUMAN Pravastatin

Approved Approved Vitamin D3 recep- Integrin alpha-L HERV-K-1p13.3 tor precursor provirus ancestral Env polyprotein

2798 Target 856 DB04258 2806 Target 146 DB04839 2814 Target 1885 DB00641

VDR HUMAN Seocalcitol ANDR HUMAN Cyproterone CODA1 HUMAN Simvastatin

Approved Approved Vitamin D3 recep- Androgen receptor Collagen alpha- tor 1(XIII) chain

2799 Target 1735 DB00175 2807 Target 136 DB00351 2815 Target 3387 DB03785

MRP2 HUMAN Pravastatin ESR1 HUMAN Megestrol MVAA PSEMV (3r,5r)-7-(( 1r,2r,..

Approved Approved Canalicular mul- Estrogen receptor 3-hydroxy-3- tispecific organic methylglutaryl- anion transporter coenzyme A 1 reductase

2800 Target 631 DB00227 2808 Target 80 DB00641 2816 Target 267 DB00641

HMDH HUMAN Lovastatin PPARA HUMAN Simvastatin PAI1 HUMAN Simvastatin

Approved Approved Approved 3-hydroxy-3- Peroxisome Plasminogen acti- methylglutaryl- proliferator- vator inhibitor 1 coenzyme A activated receptor precursor reductase alpha

2801 Target 631 DB00641 2809 Target 1608 DB00641 2817 Target 1926 DB00641

HMDH HUMAN Simvastatin BMP2 HUMAN Simvastatin MMP3 HUMAN Simvastatin

Approved Approved Approved 3-hydroxy-3- Bone morpho- Stromelysin-1 pre- methylglutaryl- genetic protein 2 cursor coenzyme A precursor reductase Drug-target pairs: R2 11

2818 Target 65 DB00641 2826 Target 183 DB01120 2834 Target 369 DB04590

MMP9 HUMAN Simvastatin VEGFA HUMAN Gliclazide FA7 HUMAN (2R)-((4-[AM INO(IM..

Approved Approved Matrix Vascular endothe- Coagulation metalloproteinase- lial growth factor factor VII 9 precursor A precursor precursor

2819 Target 54 DB00641 2827 Target 183 DB01017 2835 Target 369 DB04606

THRB HUMAN Simvastatin VEGFA HUMAN Minocycline FA7 HUMAN 2-[2-ETHANES ULFONY..

Approved Approved Prothrombin pre- Vascular endothe- Coagulation cursor lial growth factor factor VII A precursor precursor

2820 Target 1694 DB00641 2828 Target 183 DB01136 2836 Target 369 DB04758

ANGT HUMAN Simvastatin VEGFA HUMAN Carvedilol FA7 HUMAN 2-[2-ETHANES ULFONY..

Approved Approved Angiotensinogen Vascular endothe- Coagulation precursor lial growth factor factor VII A precursor precursor

2821 Target 1994 DB00175 2829 Target 183 DB01076 2837 Target 369 DB00170

PGT1 HUMAN Pravastatin VEGFA HUMAN Atorvastatin FA7 HUMAN Menadione

Approved Approved Approved Geranylgeranyl Vascular endothe- Coagulation transferase type-1 lial growth factor factor VII subunit beta A precursor precursor

2822 Target 1253 DB00641 2830 Target 1514 DB04016 2838 Target 4971 DB03014

IFNG HUMAN Simvastatin CATG HUMAN 2-[3-((Methy Q9XCU0 DESDE Heme l[1-(2..

Approved Interferon gamma Cathepsin G pre- Nonaheme precursor cursor cytochrome c

2823 Target 3811 DB00990 2831 Target 1615 DB04016 2839 Target 4902 DB03014

CP19A HUMAN Exemestane CMA1 HUMAN 2-[3-((Methy CYC9 DESDE Heme l[1-(2..

Approved Cytochrome P450 Chymase precur- Nine-heme 19A1 sor cytochrome c

2824 Target 3811 DB00894 2832 Target 369 DB04767 2840 Target 4902 DB03317

CP19A HUMAN Testolactone FA7 HUMAN N-[1-(4-CARB CYC9 DESDE Heme C AMIMID..

Approved Cytochrome P450 Coagulation Nine-heme 19A1 factor VII cytochrome c precursor

2825 Target 183 DB00641 2833 Target 369 DB04593 2841 Target 976 DB00468

VEGFA HUMAN Simvastatin FA7 HUMAN 3-((1-[3-CAR GPIX HUMAN Quinine BAMIMI..

Approved Approved Vascular endothe- Coagulation Platelet glycopro- lial growth factor factor VII tein IX precursor A precursor precursor Drug-target pairs: R2 12

2842 Target 2686 DB04764 2850 Target 811 DB00829 2858 Target 811 DB00962

TRYB2 HUMAN [4-(3-AMINOM BZRP HUMAN Diazepam BZRP HUMAN Zaleplon ETHYL-..

Approved Approved Tryptase beta-2 Peripheral-type Peripheral-type precursor benzodiazepine benzodiazepine receptor receptor

2843 Target 425 DB01242 2851 Target 811 DB01215 2859 Target 811 DB00425

Q5TZY3 HUMAN Clomipramine BZRP HUMAN Estazolam BZRP HUMAN Zolpidem

Approved Approved Approved Glutathione Peripheral-type Peripheral-type S-transferase pi benzodiazepine benzodiazepine receptor receptor

2844 Target 904 DB00903 2852 Target 811 DB01544 2860 Target 811 DB01178

GSTP1 HUMAN Ethacrynic a BZRP HUMAN Flunitrazepa BZRP HUMAN Chlormezanon cid.. m.. e..

Approved Approved Approved Glutathione Peripheral-type Peripheral-type S-transferase P benzodiazepine benzodiazepine receptor receptor

2845 Target 811 DB01559 2853 Target 811 DB00897 2861 Target 2264 DB03177

BZRP HUMAN Clotiazepam BZRP HUMAN Triazolam COBT SALTY 5-methylbenz imidaz..

Approved Approved Peripheral-type Peripheral-type Nicotinate- benzodiazepine benzodiazepine nucleotide– receptor receptor dimethylbenzimidazole phosphoribosyl- transferase

2846 Target 811 DB00628 2854 Target 811 DB00801 2862 Target 1861 DB00692

BZRP HUMAN Clorazepate BZRP HUMAN Halazepam CALCA HUMAN Phentolamine

Approved Approved Approved Peripheral-type Peripheral-type Calcitonin gene- benzodiazepine benzodiazepine related peptide 1 receptor receptor precursor

2847 Target 811 DB01068 2855 Target 811 DB00404 2863 Target 61 DB00233

BZRP HUMAN Clonazepam BZRP HUMAN Alprazolam HPPK MYCTU Aminosalicyl ic Aci..

Approved Approved Approved Peripheral-type Peripheral-type 2-amino-4- benzodiazepine benzodiazepine hydroxy-6- receptor receptor hydroxymethyldihydropteridine pyrophosphoki- nase

2848 Target 811 DB00186 2856 Target 811 DB00546 2864 Target 5714 DB04598

BZRP HUMAN Lorazepam BZRP HUMAN Adinazolam 3HAO RALME 2-AMINO-4-CH LORO-3..

Approved Approved Peripheral-type Peripheral-type 3- benzodiazepine benzodiazepine hydroxyanthranilate receptor receptor 3,4-dioxygenase

2849 Target 811 DB00231 2857 Target 811 DB01594

BZRP HUMAN Temazepam BZRP HUMAN Cinolazepam

Approved Approved Peripheral-type Peripheral-type benzodiazepine benzodiazepine receptor receptor